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FB2026_01
,
released March 12, 2026
Cy, dDuox, l(2)23Bb, Curly
ROS-generating NADPH oxidase - functions to transfer electrons across biological membranes to generate ROS by transferring electrons from NADPH to oxygen - responsible for the Curly wing phenotype - apoptosis induced proliferation
Please see the JBrowse view of Dmel\Duox for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Duox using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Duox in JBrowseMapped after having been removed from In(2L)Cy.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
polyclonal
Adult flies in which Duox expression is silenced show a marked increase in mortality rate even after a minor infection through ingestion of microbe-contaminated food.
Flies bearing dominant Cy mutations lose the curly wing phenotype when exposed to fluorescent light. There are two sensitive periods for this effect: late embryogenesis and the first half of the pupal stage. Daylight and standard tungsten light do not have the suppressive effect.
In a screen for lethal mutations that fail to complement Df(2L)C144, several mutations were isolated that showed some interaction with existing Cy alleles.
Phenotypic variation of the genetic components underlying oviposition behaviour is analysed using the complete diallel mating design.
Cy removed from In(2L)Cy still causes a local reduction in crossing over in the ed-cl region (Sederoff).
Source for merge of: Cy Duox
Source for identity of: Duox CG3131
Source for identity of: Duox Cy
'Curly' ('Cy') was shown to correspond to the 'Duox' (CG3131) gene in FBrf0230212. The merged gene was briefly called 'Cy' in FlyBase (based on precedence of that symbol), but this has been changed to 'Duox' for pragmatic reasons: 'Duox' has been the FlyBase symbol associated with the CG3131 gene model since 2005; several recent papers and constructs exist that use the 'Duox' nomenclature; the authors of FBrf0230212 refer to the gene/protein as 'duox'/'Duox' and use 'Curly'/'Cy' to refer specifically to the mutations. The original Cy[1] allele that is prevalent on Cy-associated aberrations has become 'Duox[Cy]' to recognise its history and keep it user-friendly.
