FlyBase Allele Report: Dmel\mor[1]

General Information

Symbol

Dmel\mor¹

Species

D. melanogaster

Name

FlyBase ID

FBal0012411

Feature type

allele

Associated gene

Dmel\mor

Associated Insertion(s)

Carried in Construct

Also Known As

moira¹

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

Mutagen

ethyl methanesulfonate

(Kennison and Tamkun, 1988)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dorsal appendage | germline clone

(Brizuela and Kennison, 1997)

egg | germline clone

(Brizuela and Kennison, 1997)

egg chorion | germline clone

(Brizuela and Kennison, 1997)

eye disc | somatic clone

(Collins et al., 1999)

femur | somatic clone

(Brizuela and Kennison, 1997)

haltere | somatic clone

(Brizuela and Kennison, 1997)

macrochaeta & haltere | posterior | somatic clone

(Brizuela and Kennison, 1997)

mesothoracic leg | somatic clone

(Brizuela and Kennison, 1997)

mesothoracic tarsal segment | somatic clone

(Brizuela and Kennison, 1997)

metathoracic leg | somatic clone

(Brizuela and Kennison, 1997)

prothoracic leg | anterior | somatic clone

(Brizuela and Kennison, 1997)

prothoracic leg | somatic clone

(Brizuela and Kennison, 1997)

sex comb | somatic clone

(Brizuela and Kennison, 1997)

tarsal segment | somatic clone

(Brizuela and Kennison, 1997)

tibia | somatic clone

(Brizuela and Kennison, 1997)

wing | posterior | somatic clone

(Brizuela and Kennison, 1997)

wing margin & macrochaeta | somatic clone

(Brizuela and Kennison, 1997)

wing vein | ectopic

(Rougeot et al., 2013)

Detailed Description

Statement

Reference

22.5% of heterozygous females have ectopic wing veins.

(Rougeot et al., 2013)

Heterozygotes have normal wings.

(Curtis et al., 2011)

Flies heterozygous for mor¹ show suppression of the Scer\GAL4^GMR.PS, Dref^Scer\UAS.cSa severe rough eye phenotype; eyes are modestly rough and fused ommatidia are not apparent.

(Nakamura et al., 2008)

mor¹/+ enhances the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5, P{hsp26-pt-T}39C-27 and P{hsp26-pt-T}39C-31. mor¹/+ has no effect on the telomeric position effect (TPE) of P{wA}4-4.

(Boivin et al., 2003)

mor¹ eye disc clones show a severe reduction in growth phenotype.

(Collins et al., 1999)

Homozygous clones in the haltere can give rise to wing structures; many clones in the posterior haltere differentiate large bristles characteristic of anterior wing margin. Clones induced early in development cause the haltere to be absent, small, or have a homeotic transformation. Clones induced later (48-72 hours after egg laying) show more extreme transformations of haltere to anterior wing structures than early clones. Homozygous clones in the posterior wing cause distortions in wing shape; venation is disrupted and large socketed bristles appear along the posterior wing margin. Homozygous clones in the leg cause the femur and tibia to be short and twisted, and the tarsal segments to be enlarged. Leg clones also contain extra bristles. Clones in the anterior first leg are transformed to anterior second leg or have extra sex comb teeth. Clones in the second leg are twisted, have vesicles of extra tissue, or cause the absence of the entire leg. Tarsal segments are often fused, duplicated or absent. Clones in the third leg often have partial or complete duplications of distal structures, or the entire leg morphology is abnormal. Clones in the first and third legs often cause truncations of the leg. Eggs derived from homozygous germ-line clones fail to hatch and are very abnormal. These abnormalities include collapsed eggs, eggs with partial or no chorions, small or abnormally shaped eggs and fused and thick dorsal appendages.

(Brizuela and Kennison, 1997)

Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is lighter.

(Fauvarque et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

mor¹ has visible | dominant phenotype, enhanceable by Bap60[+]/Bap60¹

(Möller et al., 2005)

Suppressed by

Statement

Reference

mor¹ has visible | dominant phenotype, suppressible by EloA[+]/EloA^G4930

(Rougeot et al., 2013)

mor¹ has visible | dominant phenotype, suppressible by EloC^SH1520/l(2)SH1520[+]

(Rougeot et al., 2013)

mor¹ has visible | dominant phenotype, suppressible by Elongin-C[+]/EloC^SH1299

(Rougeot et al., 2013)

mor¹ has abnormal size | somatic clone | larval stage phenotype, suppressible | partially | somatic clone by osa³⁰⁸/osa³⁰⁸

(Collins et al., 1999)

Enhancer of

Statement

Reference

mor[+]/mor¹ is an enhancer of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

mor[+]/mor¹ is an enhancer of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

mor[+]/mor¹ is an enhancer of abnormal neuroanatomy phenotype of brat^DG19310/brat¹¹

(Janssens et al., 2014)

mor[+]/mor¹ is an enhancer of abnormal neuroanatomy phenotype of numb^NP2301

(Janssens et al., 2014)

mor[+]/mor¹ is an enhancer of visible | dominant phenotype of Snr1^E1

(Curtis et al., 2011)

mor[+]/mor¹ is an enhancer of visible phenotype of ct^53d

(Krupp et al., 2005)

mor¹ is an enhancer of abnormal eye color phenotype of w^ph-p.lac+3/w¹¹¹⁸

(Bloyer et al., 2003)

mor¹ is an enhancer of visible | dominant phenotype of tna¹

(Gutierrez et al., 2003)

mor¹ is an enhancer of visible phenotype of BacA\p35^GMR.PH, Dp^GMR.PD, E2f1^GMR.PD

(Staehling-Hampton et al., 1999)

mor¹ is an enhancer of abnormal eye color phenotype of w^T81

(Netter et al., 1998)

NOT Enhancer of

Statement

Reference

mor¹ is a non-enhancer of visible phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Suppressor of

Statement

Reference

mor¹ is a suppressor of visible phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

mor[+]/mor¹ is a suppressor of visible phenotype of ct^K

(Krupp et al., 2005)

mor[+]/mor¹ is a suppressor of increased cell death phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PS

(Hirose et al., 2001)

mor¹ is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

mor¹ is a suppressor of visible | dominant phenotype of Antp^Ns

(Brizuela and Kennison, 1997)

mor¹ is a suppressor of visible | dominant | homeotic phenotype of Pc⁴

(Brizuela and Kennison, 1997)

mor¹ is a suppressor of visible | dominant | adult stage phenotype of Pc⁴

(Brizuela and Kennison, 1997)

mor¹ is a suppressor of visible | dominant | homeotic phenotype of Pcl¹⁰

(Brizuela and Kennison, 1997)

mor¹ is a suppressor of visible | dominant | adult stage phenotype of Pcl¹⁰

(Brizuela and Kennison, 1997)

mor[+]/mor¹ is a suppressor of visible | homeotic phenotype of Antp^Ns, Pc²

(Kennison and Tamkun, 1988)

NOT Suppressor of

Statement

Reference

mor¹ is a non-suppressor of visible phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Other

Statement

Reference

Rel^E20, mor[+]/mor¹ has abnormal immune response phenotype

(Bonnay et al., 2014)

Rel^E20, mor[+]/mor¹ has short lived | conditional phenotype

(Bonnay et al., 2014)

Su(var)3-3[+]/Su(var)3-3^ΔN, mor¹ has visible | dominant phenotype

(Curtis et al., 2011)

Hcf^HR1, mor[+]/mor¹ has visible phenotype

(Rodriguez-Jato et al., 2011)

γTub23C^Pl-2, mor¹ has visible | dominant phenotype

(Vázquez et al., 2008)

corto[+]/corto⁴²⁰, mor¹ has visible phenotype

(Lopez et al., 2001)

corto⁴²⁰, mor¹ has visible phenotype

(Lopez et al., 2001)

brm², mor¹ has visible | dominant phenotype

(Vazquez et al., 1999)

Ras85D^V12.sev, mor¹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

mor¹ has humeral bristle phenotype, enhanceable by Bap60[+]/Bap60¹

(Möller et al., 2005)

NOT Enhanced by

Statement

Reference

mor¹ has phenotype, non-enhanceable by Alh^unspecified

(Perrin et al., 2003)

Suppressed by

Statement

Reference

mor¹ has wing vein | ectopic phenotype, suppressible by EloA[+]/EloA^G4930

(Rougeot et al., 2013)

mor¹ has wing vein | ectopic phenotype, suppressible by EloC^SH1520/l(2)SH1520[+]

(Rougeot et al., 2013)

mor¹ has wing vein | ectopic phenotype, suppressible by Elongin-C[+]/EloC^SH1299

(Rougeot et al., 2013)

mor¹ has eye disc | somatic clone phenotype, suppressible | partially | somatic clone by osa³⁰⁸/osa³⁰⁸

(Collins et al., 1999)

NOT suppressed by

Statement

Reference

mor¹ has phenotype, non-suppressible by Alh^unspecified

(Perrin et al., 2003)

Enhancer of

Statement

Reference

mor[+]/mor¹ is an enhancer of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

mor[+]/mor¹ is an enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

mor[+]/mor¹ is an enhancer of type II neuroblast | increased number phenotype of brat^DG19310/brat¹¹

(Janssens et al., 2014)

mor[+]/mor¹ is an enhancer of type II neuroblast | increased number phenotype of numb^NP2301

(Janssens et al., 2014)

mor[+]/mor¹ is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Curtis et al., 2011)

mor[+]/mor¹ is an enhancer of leg phenotype of e(y)3⁴

(Chalkley et al., 2008)

mor[+]/mor¹ is an enhancer of wing phenotype of ct^53d

(Krupp et al., 2005)

mor[+]/mor¹ is an enhancer of wing vein | ectopic phenotype of net¹

(Marenda et al., 2004)

mor¹ is an enhancer of wing phenotype of tna¹

(Gutierrez et al., 2003)

mor¹ is an enhancer of eye phenotype of Scer\GAL4^ey.PH, osa^UAS.cCa

(Collins et al., 1999)

NOT Enhancer of

Statement

Reference

mor[+]/mor¹ is a non-enhancer of phenotype of ct^2s

(Krupp et al., 2005)

mor[+]/mor¹ is a non-enhancer of phenotype of ct⁶

(Krupp et al., 2005)

mor¹ is a non-enhancer of dorsocentral bristle phenotype of Chi^E

(Heitzler et al., 2003)

mor¹ is a non-enhancer of thorax phenotype of Chi^E

(Heitzler et al., 2003)

mor¹ is a non-enhancer of eye phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Suppressor of

Statement

Reference

mor[+]/mor¹ is a suppressor | partially of eye phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PS

(Nakamura et al., 2008)

mor¹ is a suppressor of eye phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

mor[+]/mor¹ is a suppressor of triple row of wing sensilla phenotype of ct^K

(Krupp et al., 2005)

mor¹ is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

mor[+]/mor¹ is a suppressor of eye phenotype of Scer\GAL4^ey.PH, asf1^UAS.cMa

(Moshkin et al., 2002)

mor[+]/mor¹ is a suppressor of eye phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PS

(Hirose et al., 2001)

mor¹ is a suppressor of wing margin phenotype of Scer\GAL4^vg.PM, sgg^S9A.UAS

(Collins and Treisman, 2000)

mor¹ is a suppressor of wing phenotype of Scer\GAL4^vg.PM, sgg^S9A.UAS

(Collins and Treisman, 2000)

mor¹ is a suppressor of antenna phenotype of Antp^Ns

(Brizuela and Kennison, 1997)

mor¹ is a suppressor of mesothoracic leg phenotype of Pc⁴

(Brizuela and Kennison, 1997)

mor¹ is a suppressor of metathoracic leg phenotype of Pc⁴

(Brizuela and Kennison, 1997)

mor¹ is a suppressor of sex comb phenotype of Pc⁴

(Brizuela and Kennison, 1997)

mor¹ is a suppressor of mesothoracic leg phenotype of Pcl¹⁰

(Brizuela and Kennison, 1997)

mor¹ is a suppressor of metathoracic leg phenotype of Pcl¹⁰

(Brizuela and Kennison, 1997)

mor¹ is a suppressor of sex comb phenotype of Pcl¹⁰

(Brizuela and Kennison, 1997)

mor[+]/mor¹ is a suppressor of antenna phenotype of Antp^Ns, Pc²

(Kennison and Tamkun, 1988)

NOT Suppressor of

Statement

Reference

mor[+]/mor¹ is a non-suppressor of phenotype of ct^2s

(Krupp et al., 2005)

mor[+]/mor¹ is a non-suppressor of phenotype of ct⁶

(Krupp et al., 2005)

mor¹ is a non-suppressor of dorsocentral bristle phenotype of Chi^E

(Heitzler et al., 2003)

mor¹ is a non-suppressor of thorax phenotype of Chi^E

(Heitzler et al., 2003)

mor¹ is a non-suppressor of eye phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Other

Statement

Reference

akirin^KG01343, mor[+]/mor¹ has larval somatic muscle cell phenotype

(Nowak et al., 2012)

Su(var)3-3[+]/Su(var)3-3^ΔN, mor¹ has wing vein | ectopic phenotype

(Curtis et al., 2011)

Hcf^HR1, mor[+]/mor¹ has leg phenotype

(Rodriguez-Jato et al., 2011)

γTub23C^Pl-2, mor¹ has wing phenotype

(Vázquez et al., 2008)

lolal^k02512, mor¹ has eye phenotype

(Mishra et al., 2003)

corto[+]/corto⁴²⁰, mor¹ has posterior crossvein phenotype

(Lopez et al., 2001)

corto⁴²⁰, mor¹ has posterior crossvein phenotype

(Lopez et al., 2001)

brm², mor¹ has wing phenotype

(Vazquez et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is exacerbated by combination with a single copy of mor¹.

(Morimoto et al., 2016)

Flies heterozygous for both Rel^E20 and mor¹ show a significant decrease in survival following Erwinia carotovora Ecc15 infection.

(Bonnay et al., 2014)

One copy of mor¹ enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutants.

One copy of mor¹ enhances the supernumerary neuroblast phenotype seen in numb^NP2301 mutant larval brains.

(Janssens et al., 2014)

The penetrance of the ectopic wing vein phenotype seen in mor¹/+ females (22.5% penetrance) is reduced if they are also heterozygous for one of EloA^G4930 (5.5% penetrance), EloC^SH1520 (1.5%) or EloC^SH1299 (6.4%).

(Rougeot et al., 2013)

Stage 16 mor¹/+ ; akirin^KG01343/+ double heterozygous embryos show disruption of the somatic muscle pattern (40% of embryos have missing, misattached or duplicated muscles in at least 2 hemisegments).

(Nowak et al., 2012)

Su(var)3-3^ΔN mor¹ double heterozygotes often have ectopic wing vein material posterior to vein L5 and distal to the posterior crossvein.

(Curtis et al., 2011)

Hcf^HR1 shows leg defects when in double heterozygous combination with mor¹ (10% penetrance).

(Rodriguez-Jato et al., 2011)

mor¹ acts as strong dominant enhancer of the penetrance of the e(y)3⁴/Y bent-leg phenotype in male flies.

(Chalkley et al., 2008)

γTub23C^Pl-2 results in a held-out wing phenotype in double heterozygous combination with mor¹ (10% penetrance).

(Vázquez et al., 2008)

The penetrance of the loss of humeral bristle phenotype seen in mor¹/+ flies is increased by Bap60¹/+ from 3% to 7%.

(Möller et al., 2005)

The addition of lolal^k02512/+ to heterozygous mor¹ animals produces rough eyes.

(Mishra et al., 2003)

Strongly suppresses the CycE^JP rough eye phenotype.

(Brumby et al., 2002)

mor¹/+ suppresses the rough eye phenotype due to Scer\GAL4^ey.PH; asf1^Scer\UAS.cMa.

(Moshkin et al., 2002)

A mor¹/+ background significantly suppresses the rough eye phenotype found in flies expressing Dref^Scer\UAS.cSa under the control of Scer\GAL4^GMR.PS.

(Hirose et al., 2001)

mor¹ corto⁴²⁰ double heterozygotes show posterior crossvein defects.

(Lopez et al., 2001)

Mutant heterozygotes show a moderate enhancement of the eye phenotype see in P{UAS-lacZ.Abd-B.5F24} leading to lighter eyes.

(Cavalli, 1999)

The addition of mor¹ enhances the eye size phenotype seen in osa^Scer\UAS.cCa/Scer\GAL4^ey.PH flies, occasionally resulting in missing eyes. The reduction in growth seen in mor¹ clones is partially rescued by the addition of osa³⁰⁸.

(Collins et al., 1999)

Enhances the phenotype of E2f^GMR.PD Dp^GMR.PD BacA\p35^GMR.PH flies.

(Staehling-Hampton et al., 1999)

brm² shows some interaction in double heterozygous combination with mor¹; slightly more than 20% of flies have held-out wings.

(Vazquez et al., 1999)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by mor¹.

(Maixner et al., 1998)

Weak enhancer of eye pigment phenotype of w^T81.

(Netter et al., 1998)

Suppresses the antenna to leg transformation phenotype of Pc², Antp^Ns/+. Causes between 50% and 100% suppression of the Pc⁴/+ extra sex combs phenotype.

(Kennison and Tamkun, 1988)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is exacerbated by combination with a single copy of mor¹.

(Morimoto et al., 2016)

Complementation and Rescue Data

Fails to complement

mor^GS-A897

(Krupp et al., 2005)

mor^ksh-10

(Staehling-Hampton et al., 1999)

mor^ksh-9

(Staehling-Hampton et al., 1999)

Rescued by

mor⁶/mor¹ is rescued by mor^+t11.8

(Crosby et al., 1999)