FlyBase Allele Report: Scer\GAL4[nrv2.PS]

nrv2 reporter expression is observed in a subset of glial cells in the adult optic lobe. Glial cells in the lamina were identified as the satellite glial cells. Staining is also observed in the inner and outer optic chiasm giant glial cells and in medulla neuropil glial cells.

(Górska-Andrzejak et al., 2009)

Used as marker for adult glial cell cell bodies.

(Oland et al., 2008)

Marker for

embryonic/larval wrapping glial cell

(Schmidt et al., 2012)

glial cell

(Oland et al., 2008)

nervous system

(Sun et al., 1999)

Reflects expression of

nrv2

(Spéder and Brand, 2014, Schmidt et al., 2012, Górska-Andrzejak et al., 2009, Beckervordersandforth et al., 2008, Oland et al., 2008, Sun et al., 2001, Sun et al., 1999)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior, with Atpα^D369N.UAS

(Sun et al., 2001)

abnormal behavior, with Atpα^UAS.cSa

(Sun et al., 2001)

abnormal behavior | heat sensitive, with zyd^GD3723

(Melom and Littleton, 2013)

abnormal behavior | heat sensitive, with zyd^JF01872

(Melom and Littleton, 2013)

abnormal behavior | larval stage, with rpr^UAS.cZa

(Pereanu et al., 2007)

abnormal cell shape | larval stage, with shg^ex.UAS

(Dumstrei et al., 2003)

abnormal circadian rhythm, with Fer1HCH^UAS.cMa

(Kosmidis et al., 2011)

abnormal circadian rhythm, with Fer2LCH^UAS.cMa

(Kosmidis et al., 2011)

abnormal eclosion, with PI31^KK107597

(Liu et al., 2019)

abnormal gravitaxis, with Zzzz\Poly-Ala^{A37.UAS.EGFP,Tag:NLS(SV40-largeT)}

(Berger et al., 2006)

abnormal locomotor behavior, with CG8708^KK111444

(Fedotov et al., 2014)

abnormal locomotor behavior, with CG34460^KK115394

(Fedotov et al., 2014)

abnormal locomotor behavior, with Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Lin et al., 2015, Jia et al., 2013)

abnormal locomotor behavior, with jing^JF02345

(Fedotov et al., 2014)

abnormal locomotor behavior, with Sps2^KK106069

(Fedotov et al., 2014)

abnormal locomotor behavior | adult stage, with Zzzz\Poly-Ala^{A37.UAS.EGFP,Tag:NLS(SV40-largeT)}

(Berger et al., 2006)

abnormal locomotor behavior | adult stage | progressive, with Hsap\ATXN1^82Q.UAS

(Ruan et al., 2015, Branco et al., 2008)

abnormal locomotor behavior | adult stage | progressive, with Hsap\HTT^{128Q.1-336.UAS}

(Branco et al., 2008)

abnormal locomotor behavior | chemical conditional, with Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Jia et al., 2013)

abnormal locomotor rhythm | heat sensitive, with lark¹, lark^RNAi.UAS.cSb

(Sundram et al., 2012)

abnormal locomotor rhythm | heat sensitive, with lark^RNAi.UAS.cSb

(Sundram et al., 2012)

abnormal neuroanatomy | conditional, with drpr^RNAi.UAS

(Neukomm et al., 2014)

abnormal neuroanatomy | third instar larval stage, with Khc^GD12278

(Schmidt et al., 2012)

abnormal song, with CG34460^KK115394

(Fedotov et al., 2014)

abnormal song, with fipi^KK107002

(Fedotov et al., 2014)

abnormal song, with Hacd1^KK101803

(Fedotov et al., 2014)

abnormal song, with Mef2^JF03115

(Fedotov et al., 2014)

abnormal song, with Sps2^KK106069

(Fedotov et al., 2014)

bang sensitive, with kcc^HMS01058

(Rusan et al., 2014)

chemical resistant, with Atpα^UAS.cSa

(Sun et al., 2001)

chemical sensitive, with Atpα^D369N.UAS

(Sun et al., 2001)

chemical sensitive, with List^GD2072

(Kasuya et al., 2009)

decreased cell number | third instar larval stage, with Egfr^DN.UAS.cBa

(Matzat et al., 2015)

decreased efficacy of learning | adult stage, with LIMK1^UAS.Tag:HA

(Zhuravlev et al., 2024)

increased cell death | adult stage, with Hsap\ATXN1^82Q.UAS

(Ruan et al., 2015)

increased cell number, with Pvf2^d02444

(Winkler et al., 2021)

increased cell number, with Pvf2^d02444, Scer\GAL80^R90C03.PK

(Winkler et al., 2021)

lethal, with rpr^UAS.cZa

(Pereanu et al., 2007)

lethal | pharate adult stage, with Fs^UAS.cPa

(Pentek et al., 2009)

lethal | P-stage, with Fs^UAS.cPa

(Pentek et al., 2009)

lethal - all die during pharate adult stage, with PI31^KK107597

(Liu et al., 2019)

paralytic, with kcc^HMS01058

(Rusan et al., 2014)

partially lethal, with Atpα^D369N.UAS

(Sun et al., 2001)

partially lethal, with Atpα^UAS.cSa

(Sun et al., 2001)

partially lethal - majority die, with Zzzz\Poly-Ala^{A37.UAS.EGFP,Tag:NLS(SV40-largeT)}

(Berger et al., 2006)

short lived, with Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Jia et al., 2013)

short lived, with Pvf2^d02444

(Winkler et al., 2021)

short lived, with Zzzz\Poly-Ala^{A37.UAS.EGFP,Tag:NLS(SV40-largeT)}

(Berger et al., 2006)

short lived | chemical conditional, with Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Jia et al., 2013)

viable, with COX5B^GD6659

(Kemppainen et al., 2014)

viable, with COX6B^GD13061

(Kemppainen et al., 2014)

viable, with dre4^GL00017

(Ma et al., 2023)

viable, with Gem3^GD17221

(Borg and Cauchi, 2013, Cauchi et al., 2008)

viable, with Gem3^ΔN.UAS

(Cauchi et al., 2008)

viable, with Hsap\SMN1^UAS.cMa

(Borg and Cauchi, 2013)

viable, with Lam^UAS.cMAa

(Muñoz-Alarcón et al., 2007)

viable, with rig^NIG.11171R

(Borg and Cauchi, 2013)

viable, with Rnor\P2rx2^UAS.cLa

(Lima and Miesenbock, 2005)

Phenotype Manifest In

adult brain, with Hsap\ATXN1^82Q.UAS

(Ruan et al., 2015)

air bubble, with Fs^UAS.cPa

(Pentek et al., 2009)

anterior pupal spiracle, with Fs^UAS.cPa

(Pentek et al., 2009)

central nervous system, with Pvf2^d02444

(Winkler et al., 2021)

central nervous system, with Pvf2^d02444, Scer\GAL80^R90C03.PK

(Winkler et al., 2021)

embryonic/larval cell body glial cell, with shg^ex.UAS

(Dumstrei et al., 2003)

embryonic/larval CNS subperineurial glial cell | third instar larval stage, with vn^GD2321

(Matzat et al., 2015)

embryonic/larval PNS perineurial glial cell | third instar larval stage, with Egfr^DN.UAS.cBa

(Matzat et al., 2015)

embryonic/larval wrapping glial cell | third instar larval stage, with Egfr^DN.UAS.cBa

(Matzat et al., 2015)

embryonic/larval wrapping glial cell | third instar larval stage, with vn^GD2321

(Matzat et al., 2015)

embryonic/larval wrapping glial cell of the eye disc | third instar larval stage, with Khc^GD12278

(Schmidt et al., 2012)

glial cell | larval stage, with rpr^UAS.cZa

(Pereanu et al., 2007)

lamina cortex & satellite glial cell, with shg^ex.UAS

(Dumstrei et al., 2003)

leg | pharate adult stage, with Fs^UAS.cPa

(Pentek et al., 2009)

nerve | larval stage, with Bsg^GD15718

(Böhme et al., 2021)

nerve | larval stage, with Ctet\tetX^TNT-LC.UAS

(Böhme et al., 2021)

plasmatocyte | increased number, with Pvf2^d02444

(Winkler et al., 2021)

plasmatocyte | increased number, with Pvf2^d02444, Scer\GAL80^R90C03.PK

(Winkler et al., 2021)

pupa, with Fs^UAS.cPa

(Pentek et al., 2009)

wing vein L1 | conditional, with drpr^RNAi.UAS

(Neukomm et al., 2014)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, enhanceable by Scer\GAL4^da.PU/Tg^GD10774

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, enhanceable by Scer\GAL4^da.PU/Tg^KK101591

(Lin et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior | adult stage | progressive phenotype, enhanceable by Nmnat^UAS.PC, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has increased cell death | adult stage phenotype, enhanceable by Nmnat^UAS.PC, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^nrv2.PS has abnormal locomotor behavior | adult stage | progressive phenotype, enhanceable by mub^EP3623, Scer\GAL4^nrv2.PS

(Branco et al., 2008)

Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^nrv2.PS has abnormal locomotor behavior | adult stage | progressive phenotype, enhanceable by vib^EP651, Scer\GAL4^nrv2.PS

(Branco et al., 2008)

NOT Enhanced by

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior | adult stage | progressive phenotype, non-enhanceable by Nmnat^cyt.UAS.PC, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has increased cell death | adult stage phenotype, non-enhanceable by Nmnat^cyt.UAS.PC, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Suppressed by

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by Nmnat^UAS.PD, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has increased cell death | adult stage phenotype, suppressible | partially by Nmnat^UAS.PD, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by rl¹

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by rl¹

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by Sos^KG10074

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by Sos^KG10074

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by Ras85D⁰⁶⁶⁷⁷

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by Ras85D⁰⁶⁶⁷⁷

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by Raf^KK100982, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by Raf^KK100982, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by Fnta^KK100303, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by Fnta^KK100303, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by JIL-1^KK101300, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by JIL-1^KG08229

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by Dsor1^G79

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by Dsor1^G79

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by mub^EP3623, Scer\GAL4^nrv2.PS

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by vib^EP651, Scer\GAL4^nrv2.PS

(Branco et al., 2008)

Enhancer of

Statement

Reference

Nmnat^UAS.PC, Scer\GAL4^nrv2.PS is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Nmnat^UAS.PC, Scer\GAL4^nrv2.PS is an enhancer of increased cell death | adult stage phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

mub^EP3623, Scer\GAL4^nrv2.PS is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^nrv2.PS

(Branco et al., 2008)

vib^EP651, Scer\GAL4^nrv2.PS is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^nrv2.PS

(Branco et al., 2008)

NOT Enhancer of

Statement

Reference

Nmnat^cyt.UAS.PC, Scer\GAL4^nrv2.PS is a non-enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Nmnat^cyt.UAS.PC, Scer\GAL4^nrv2.PS is a non-enhancer of increased cell death | adult stage phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Suppressor of

Statement

Reference

Mmus\Slc5a2^UAS.cYa/Scer\GAL4^nrv2.PS is a suppressor of female sterile phenotype of bumpel², kumpel²

(Yildirim et al., 2022)

Nmnat^UAS.PD, Scer\GAL4^nrv2.PS is a suppressor | partially of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Nmnat^UAS.PD, Scer\GAL4^nrv2.PS is a suppressor | partially of increased cell death | adult stage phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Raf^KK100982, Scer\GAL4^nrv2.PS is a suppressor | partially of abnormal locomotor behavior phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Raf^KK100982, Scer\GAL4^nrv2.PS is a suppressor | partially of short lived phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Fnta^KK100303, Scer\GAL4^nrv2.PS is a suppressor | partially of abnormal locomotor behavior phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Fnta^KK100303, Scer\GAL4^nrv2.PS is a suppressor | partially of short lived phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Park et al., 2013)

JIL-1^KK101300, Scer\GAL4^nrv2.PS is a suppressor | partially of short lived phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Cint\AOX^UAS.cFa/Scer\GAL4^nrv2.PS is a suppressor of abnormal locomotor behavior phenotype of dj-1β^GE23381

(Fernandez-Ayala et al., 2009)

mub^EP3623, Scer\GAL4^nrv2.PS is a suppressor | partially of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Branco et al., 2008)

vib^EP651, Scer\GAL4^nrv2.PS is a suppressor | partially of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Branco et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has adult brain phenotype, enhanceable by Nmnat^UAS.PC, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

NOT Enhanced by

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has adult brain phenotype, non-enhanceable by Nmnat^cyt.UAS.PC, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Suppressed by

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has adult brain phenotype, suppressible | partially by Nmnat^UAS.PD, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Enhancer of

Statement

Reference

Nmnat^UAS.PC, Scer\GAL4^nrv2.PS is an enhancer of adult brain phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

NOT Enhancer of

Statement

Reference

Nmnat^cyt.UAS.PC, Scer\GAL4^nrv2.PS is a non-enhancer of adult brain phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Suppressor of

Statement

Reference

Nmnat^UAS.PD, Scer\GAL4^nrv2.PS is a suppressor | partially of adult brain phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^nrv2.PS/Cpes^UAS.cKa rescues Cpes^KO

(Kunduri et al., 2018)

RyR^UAS.Tag:V5/Scer\GAL4^nrv2.PS rescues RyR^GS21220/RyR^k04913

(Gao et al., 2013)

zyd^UAS.cMa/Scer\GAL4^nrv2.PS rescues zyd¹

(Melom and Littleton, 2013)

wit^UAS.cMa/Scer\GAL4^nrv2.PS rescues wit^unspecified

(Marques et al., 2002)

Fails to rescue

Cpes^UAS.Tag:V5/Scer\GAL4^nrv2.PS fails to rescue Cpes¹

(Chen et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (7)

Bloomington

6799

w^*; P{nrv2-GAL4.S}8

6800

w^*; P{nrv2-GAL4.S}3

6797

w^*; P{nrv2-GAL4.S}3; P{nrv2-GAL4.S}8

6794

w^*; P{nrv2-GAL4.S}8 P{UAS-GFP.S65T}eg^T10

6795

w^*; P{nrv2-GAL4.S}3 P{UAS-GFP.S65T}Myo31DF^T2

602898

w^*; P{nrv2-GAL4.S}3/CyO, P{Wee-P.ph0}2; P{R90C03-GAL80.K}attP2/TM6B, Tb¹

6796

w^*; P{nrv2-GAL4.S}3 P{UAS-GFP.S65T}Myo31DF^T2; P{nrv2-GAL4.S}8 P{UAS-GFP.S65T}eg^T10

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Scer\GAL4^Nrv2.PS

Scer\GAL4^nrv2.PS

Name Synonyms

Nervana 2 promoter construct of Sun

(Sun et al., 1999)

Secondary FlyBase IDs

References (105)

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