ENY2, late boundary complex, LBC
Please see the JBrowse view of Dmel\e(y)2 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.40
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
Component of the nuclear pore complex (NPC)-associated TREX-2/AMEX complex (anchoring and mRNA export complex), composed of e(y)2, xmas and PCID2 (PubMed:18034162, PubMed:27016737). Within the TREX-2/ AMEX complex, interactions with xmas is required for localization to the nuclear periphery (PubMed:18034162). Component of the SAGA transcription coactivator-HAT complexes, at least composed of Ada2b, e(y)2, Pcaf/Gcn5, Taf10 and Nipped-A/Trrap (PubMed:18034162, PubMed:19947544). Within the SAGA complex, e(y)2, Sgf11, and not/nonstop form an additional subcomplex of SAGA called the DUB module (deubiquitination module) (By similarity). Component of the THO complex, composed of at least e(y)2, HPR1, THO2, THOC5, THOC6 and THOC7 (PubMed:20048002, PubMed:20714859). Interacts with Taf9 (PubMed:11438676). Interacts with su(Hw) (via zinc fingers) (PubMed:17643381). Interacts with the nuclear pore complex (NPC) (PubMed:18034162, PubMed:20048002). Interaction between the TREX-2/AMEX complex and the ORC complex is required for ORC localization to mRNPs, and consequently mRNA export (PubMed:27016737, Ref.11). Within the TREX-2/AMEX-ORC complex, interacts with Orc6 and (via N-terminus or C-terminus) with Orc3 (PubMed:27016737, Ref.11). Interacts with the zinc finger protein CG9890 (PubMed:30713769).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\e(y)2 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\e(y)2 in JBrowse1-35
1-36.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mutations at the e(y)2 loci enhance the phenotypic expression of several insertion mutations of y without exerting any effect on mdg4 induced mutations at other loci. One mutation in e(y)2 is due to insertion of a Stalker element.
Source for merge of: e(y)2 CG15191
"e(y)2" appears to have been derived from "e(y)2b" by retroposition; "e(y)2"is composed of a single exon and contains 17bp direct repeats beginning at positions -12 and +528 nucleotides relative to the transcription start site (these repeats are a hallmark of retroposition).
FlyBase curator comment: the insertion in the "e03298" Exelixis line (PBac{RB}CG11695e03298) was originally assigned to the e(y)2 gene in FBrf0179797, resulting in the "e(y)2e03298" (FBal0159294) allele. However, FBrf0184340 shows that the insertion is actually within CG11695.
Source for merge of e(y)2 CG15191 was sequence comparison ( date:000815 ).