FB2025_01 , released February 20, 2025
Gene: Dmel\Sas-4
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General Information
Symbol
Dmel\Sas-4
Species
D. melanogaster
Name
Spindle assembly abnormal 4
Annotation Symbol
CG10061
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011020
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Spindle assembly abnormal 4 (Sas-4) encodes a centriole protein that is essential for centriole assembly. It is recruited to centrioles through an interaction with the centriole protein encoded by ana2, and it helps recruit microtubules to the centriole. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DSas-4, Sas4, CPAP, Dsas4, l(3)s2214

Key Links
Genomic Location
Cytogenetic map
84C6-84C7
Sequence location
Recombination map
3-48
RefSeq locus
NT_033777 REGION:7151367..7154219
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables molecular adaptor activity
(Gopalakrishnan et al., 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables tubulin binding
inferred from biological aspect of ancestor with PANTHER:PTN000817566
(GO Reference Genome Project, 2011-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
involved_in asymmetric cell division
inferred from direct assay
(Januschke and Gonzalez, 2010)
inferred from mutant phenotype
(Basto et al., 2006)
involved_in centriole replication
inferred from mutant phenotype
(Dobbelaere et al., 2008, Peel et al., 2007, Basto et al., 2006)
involved_in centrosome cycle
inferred from mutant phenotype
(Gopalakrishnan et al., 2011, Blachon et al., 2009, Rodrigues-Martins et al., 2008, Basto et al., 2006)
involved_in centrosome separation
inferred from mutant phenotype
(Gallaud et al., 2014)
involved_in cilium assembly
inferred from mutant phenotype
(Basto et al., 2006)
involved_in locomotion
inferred from mutant phenotype
(Basto et al., 2006)
involved_in male meiotic nuclear division
inferred from mutant phenotype
(Rodrigues-Martins et al., 2008)
involved_in microtubule polymerization
inferred from mutant phenotype
(Gallaud et al., 2014)
involved_in protein localization to pericentriolar material
inferred from mutant phenotype
(Gopalakrishnan et al., 2011)
involved_in syncytial blastoderm mitotic cell cycle
inferred from mutant phenotype
(Rodrigues-Martins et al., 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in centriole elongation
inferred from biological aspect of ancestor with PANTHER:PTN000817566
(GO Reference Genome Project, 2011-)
involved_in cilium assembly
inferred from biological aspect of ancestor with PANTHER:PTN000817566
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
colocalizes_with centriole
inferred from direct assay
(Gottardo et al., 2016)
located_in centriole
inferred from direct assay
(Stevens et al., 2010, Blachon et al., 2009, Dobbelaere et al., 2008, Goshima et al., 2007, Peel et al., 2007, Basto et al., 2006)
located_in cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in pericentriolar material
inferred from direct assay
(Gopalakrishnan et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in centriole
inferred from biological aspect of ancestor with PANTHER:PTN000817566
(GO Reference Genome Project, 2011-)
is_active_in centrosome
inferred from biological aspect of ancestor with PANTHER:PTN000817566
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Spindle assembly abnormal 4 (Sas-4) encodes a centriole protein that is essential for centriole assembly. It is recruited to centrioles through an interaction with the centriole protein encoded by ana2, and it helps recruit microtubules to the centriole. [Date last reviewed: 2019-03-14]
Summary (Interactive Fly)

regulation of growth of the neuromuscular junction presynaptically by inhibition of BMP/TGF-β signaling - CNS - muscle - plasma membrane to endosome traffic

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Sas-4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VI72)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sas-4-RA
FBtr0081569
NM_141444
2802
901
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Sas-4-PA
FBpp0081088
103.3
901
7.79
Q9VI72
NP_649701
AAF54053
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sas-4 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.14

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with centriole
inferred from direct assay
(Gottardo et al., 2016)
located_in centriole
inferred from direct assay
(Stevens et al., 2010, Blachon et al., 2009, Dobbelaere et al., 2008, Goshima et al., 2007, Peel et al., 2007, Basto et al., 2006)
located_in cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in pericentriolar material
inferred from direct assay
(Gopalakrishnan et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sas-4 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 39 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sas-4
Transgenic constructs containing regulatory region of Sas-4
Aberrations (Deficiencies and Duplications) ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | recessive
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
male sterile
Other Phenotypes
Allele
abnormal cell cycle | somatic clone
abnormal cell polarity | somatic clone
abnormal cytokinesis
abnormal developmental rate
abnormal mating
abnormal meiotic cell cycle
abnormal mitotic cell cycle
abnormal mitotic cell cycle | third instar larval stage
increased cell number | third instar larval stage
increased occurrence of cell division | third instar larval stage
neoplasia | third instar larval stage
short lived
some die during immature adult stage | recessive
uncoordinated
uncoordinated (with Sas-4s2214)
uncoordinated (with Sas-4Δ90)
uncoordinated (with Sas-4Δ150)
uncoordinated (with Sas-4ΔPN2-3)
uncoordinated | recessive
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
aster, with Sas-4s2214
aster, with Sas-4ΔT.GFP
central protocerebral neuroblast | third instar larval stage
centriole
centriole | ectopic, with Scer\GAL4VP16.mat.αTub67C
centriole | progressive
centrosome
ciliary rootlet
cilium
larval brain
larval neuroblast | increased number | third instar larval stage
male germline stem cell
male germline stem cell | progressive
mitotic spindle | third instar larval stage
motile cilium
neuroblast
primary spermatocyte
sensory neuron | embryonic stage 16
spermatid
spermatid axoneme, with Sas-4s2214
spermatid axoneme, with Sas-4ΔT.GFP
spermatozoon
spindle
trichogen cell | increased number, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (4)
Hsap\CPAP
10 of 14
Yes
Yes
1  
Hsap\TCP10L
2 of 14
No
Yes
Hsap\TCP10L2
1 of 14
No
Yes
Hsap\TCP10L3
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Cenpj
9 of 14
Yes
Yes
Rnor\Tcp10b
7 of 14
No
Yes
Mus musculus (laboratory mouse) (4)
Mmus\Cenpj
10 of 14
Yes
Yes
Mmus\Tcp10b
6 of 14
No
Yes
Mmus\Tcp10c
6 of 14
No
Yes
Mmus\Tcp10a
5 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\tcp10l2
4 of 13
Yes
Yes
Xtro\cenpj
3 of 13
No
Yes
Danio rerio (Zebrafish) (1)
Drer\cenpj
9 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP001897
6 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Sas-4. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Sas-4s2214
exacerbates  microcephaly
modeled by Mad11
(Poulton et al., 2017)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
CPAP; centrosome assembly and centriole elongation protein
10 of 14
609279
 
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Show/hide secondary interactors 
(data from AllianceMine provided by esyN)
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Other Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Sas-4
two hybrid
(Galletta et al., 2016)
Sas-4 - CG13920
experimental knowledge based
(Guruharsha et al., 2011)
Sas-4 - Cep135
pull down, western blot, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, anti tag western blot, two hybrid
(Galletta et al., 2016, Zheng et al., 2014)
Sas-4 - Cnb
anti tag coimmunoprecipitation, peptide massfingerprinting
(Januschke et al., 2013)
Sas-4 - Cp110
two hybrid
(Galletta et al., 2016)
Sas-4 - Cp190
anti tag coimmunoprecipitation, western blot, pull down, anti bait coimmunoprecipitation, peptide massfingerprinting
(Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011)
Sas-4 - Grip128
anti bait coimmunoprecipitation, peptide massfingerprinting, cosedimentation through density gradient, western blot, pull down
(Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011)
Sas-4 - Grip163
anti bait coimmunoprecipitation, western blot, cosedimentation through density gradient
(Gopalakrishnan et al., 2012)
Sas-4 - Grip75
anti bait coimmunoprecipitation, cosedimentation through density gradient, western blot
(Gopalakrishnan et al., 2012)
Sas-4 - Grip84
anti bait coimmunoprecipitation, western blot, cosedimentation through density gradient
(Gopalakrishnan et al., 2012)
Sas-4 - Grip91
anti bait coimmunoprecipitation, cosedimentation through density gradient, western blot
(Gopalakrishnan et al., 2012)
Sas-4 - Lk6
two hybrid
(Galletta et al., 2016)
Sas-4 - Nek2
two hybrid
(Galletta et al., 2016)
Sas-4 - Plp
anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, two hybrid, peptide massfingerprinting, pull down, cosedimentation through density gradient
(Galletta et al., 2016, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011)
Sas-4 - SAK
pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot, isothermal titration calorimetry, predetermined participant
(Ábrahám et al., 2023, McLamarrah et al., 2020)
Sas-4 - Sas-6
experimental knowledge based
(Guruharsha et al., 2011)
Sas-4 - ana1
two hybrid
(Galletta et al., 2016)
Sas-4 - ana2
pull down, anti tag western blot, anti tag coimmunoprecipitation, two hybrid, x-ray crystallography, bio-layer interferometry, predetermined participant, autoradiography, anti bait coimmunoprecipitation, western blot
(McLamarrah et al., 2020, Moyer and Holland, 2019, McLamarrah et al., 2018, Galletta et al., 2016, Dzhindzhev et al., 2014, Zheng et al., 2014, Cottee et al., 2013)
Sas-4 - ana3
anti bait coimmunoprecipitation, peptide massfingerprinting, western blot
(Gopalakrishnan et al., 2011)
Sas-4 - asl
pull down, western blot, anti bait coimmunoprecipitation, cosedimentation through density gradient, two hybrid, anti tag western blot, peptide massfingerprinting, anti tag coimmunoprecipitation, autoradiography
(Galletta et al., 2016, Galletta et al., 2016, Klebba et al., 2015, Zheng et al., 2014, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011, Conduit et al., 2010, Dzhindzhev et al., 2010)
Sas-4 - aurA
two hybrid
(Galletta et al., 2016)
Sas-4 - cnn
anti bait coimmunoprecipitation, cosedimentation through density gradient, western blot, peptide massfingerprinting, two hybrid, pull down, anti tag coimmunoprecipitation, anti tag western blot
(Galletta et al., 2016, Conduit et al., 2015, Zheng et al., 2014, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011, Conduit et al., 2010)
Sas-4 - polo
two hybrid
(Galletta et al., 2016)
Sas-4 - spd-2
two hybrid
(Galletta et al., 2016)
Sas-4 - t-Grip128
two hybrid, pull down, autoradiography
(Alzyoud et al., 2024)
Sas-4 - t-Grip91
two hybrid, pull down, autoradiography
(Alzyoud et al., 2024)
Sas-4 - βTub56D
pull down, western blot, anti bait coimmunoprecipitation, cosedimentation through density gradient, anti tag coimmunoprecipitation
(Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011)
Sas-4 - γTub23C
pull down, western blot, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cosedimentation through density gradient
(Conduit et al., 2015, Zheng et al., 2014, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011)
Sas-4 - γTub37C
pull down, western blot, anti bait coimmunoprecipitation, cosedimentation through density gradient, anti tag coimmunoprecipitation
(Conduit et al., 2015, Zheng et al., 2014, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011)
Summary of Genetic Interactions
esyN Network Diagram
Show/hide secondary interactors 
(data from AllianceMine provided by esyN)
esyN Network Key:
Suppression
Enhancement
Other Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Sas-4
enhanceable
BubR1
(Caous et al., 2015)
Sas-4
suppressible
BubR1
(Caous et al., 2015)
Sas-4
enhanceable
ens
(Gallaud et al., 2014)
Sas-4
enhanceable
mad2
(Poulton et al., 2017, Caous et al., 2015)
Sas-4
suppressible
mad2
(Caous et al., 2015)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
BubR1
enhanceable
Sas-4
(Caous et al., 2015)
Cp110
enhanceable
Sas-4
(Franz et al., 2013)
ens
enhanceable
Sas-4
(Gallaud et al., 2014)
Mad1
enhanceable
Sas-4
(Poulton et al., 2017)
SAK
suppressible
Sas-4
(Sabino et al., 2011, Basto et al., 2008)
vih
enhanceable
Sas-4
(Braun et al., 2021)
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-48
Cytogenetic map
84C6-84C7
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
84C6-84C7
Limits computationally determined from genome sequence between P{lacW}l(3)L2100L2100 and P{EP}EP3060EP3060
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
84C4-84C6
(determined by in situ hybridisation)
(Spradling et al., 1999)
84C4-84C6
(BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location

3-48

(FlyBase, 2016)

3-44.2

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (8)
Genomic Clones (19)
cDNA Clones (1)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          monoclonal

          (Ramani et al., 2018, Gopalakrishnan et al., 2011)

          polyclonal

          (Novak et al., 2016)
          Commercially Available Antibodies
           
          Cell Line Information
          Other Comments

          Sas-4 is involved in centriole duplication.

          (Dobbelaere et al., 2008)

          RNAi screen using dsRNA made from templates generated with primers directed against this gene results in the spindles that are either anastral (no γ-tubulin staining at the poles) or monastral (only one pole with γ-tubulin staining) when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

          (Goshima et al., 2007)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: l(3)s2214 CG10061

          (Toub, 2003.10.22)
          Additional comments
          Nomenclature History
          Source for database identify of

          Source for identity of: Sas-4 l(3)s2214

          (Basto et al., 2006)
          Nomenclature comments
          Etymology

          Named "Sas-4" after the C. elegans ortholog.

          (FlyBase, 2009-)
          Synonyms and Secondary IDs (26)
          Reported As
          Symbol Synonym
          CENPJ
          (Naveed et al., 2018)
          CG10061
          (Hosono et al., 2015, Ni et al., 2011.7.19, Müller et al., 2010, Keleman et al., 2009.8.5, Dobbelaere et al., 2008, Goshima et al., 2007, Basto et al., 2006, Provost et al., 2006, Avidor-Reiss et al., 2004, Giot et al., 2003)
          CPAP
          (Marthiens and Basto, 2020, Carvalho-Santos et al., 2010)
          D-Sas4
          (Dobbelaere et al., 2008)
          D-sas4
          (Yuan et al., 2012)
          DSAS-4
          (Martins et al., 2010, Rodrigues-Martins et al., 2008, Rodrigues-Martins et al., 2007)
          DSas-4
          (Carty and Dunleavy, 2020, Conduit et al., 2014, Franz et al., 2013, Lecland et al., 2013, Gatti et al., 2012, Matunis et al., 2012, Nguyen et al., 2011, Riparbelli and Callaini, 2011, Conduit et al., 2010, Gogendeau and Basto, 2010, Januschke and Gonzalez, 2010, Stevens et al., 2010, Stevens et al., 2010, Moutinho-Pereira et al., 2009, Stevens et al., 2009, Basto et al., 2008, Somma et al., 2008, Dix and Raff, 2007, Dix and Raff, 2007, Giansanti et al., 2007, Goshima et al., 2007, Goshima et al., 2007, Peel et al., 2007, Stevens et al., 2007, Badano and Katsanis, 2006, Basto et al., 2006)
          DSas4
          (Roth et al., 2015, Guha et al., 2008)
          DmSas4
          (Moyer and Holland, 2019)
          Dsas-4
          (Lucas and Raff, 2007)
          Dsas4
          (Song et al., 2023, Reschen et al., 2012)
          SAS-4
          (Ito et al., 2019, Fu et al., 2015, Klebba et al., 2015, Brownlee and Rogers, 2013, Liu, 2010, Anderson et al., 2009)
          SAS4
          (Dobbelaere et al., 2023, Jana et al., 2018, Pimenta-Marques et al., 2016, Lerit et al., 2015, Lerit and Rusan, 2013, Carvalho-Santos et al., 2010, Matos et al., 2009)
          Sas-4
          (Jaiswal et al., 2024, Blümel et al., 2022, Frappaolo et al., 2022, Xiang et al., 2022, Alvarez-Rodrigo et al., 2021, Gillard et al., 2021, Persico et al., 2021, Wainman, 2021, Debec et al., 2020, Gerlach and Herranz, 2020, Riparbelli et al., 2020, Robinson et al., 2020, Singh et al., 2020, Blake-Hedges and Megraw, 2019, Gambarotto et al., 2019, Jo et al., 2019, Gene Disruption Project members, 2018-, Ramani et al., 2018, Riparbelli et al., 2018, Tillery et al., 2018, Dewey and Johnston, 2017, Lattao et al., 2017, Gottardo et al., 2016, Gottardo et al., 2016, Khire et al., 2016, Novak et al., 2016, Ricolo et al., 2016, Sarov et al., 2016, Saurya et al., 2016, Baumbach et al., 2015, Chen et al., 2015, Conduit et al., 2015, Homem et al., 2015, Khire et al., 2015, Venkei and Yamashita, 2015, Afonso et al., 2014, Chen et al., 2014, Conduit et al., 2014, Gallaud et al., 2014, Riparbelli et al., 2014, Taniguchi et al., 2014, Zheng et al., 2014, Januschke et al., 2013, Fabian and Brill, 2012, Gopalakrishnan et al., 2012, Zhao et al., 2012, Mottier-Pavie et al., 2011, Sabino et al., 2011, Van De Bor et al., 2011, Dzhindzhev et al., 2010, Goodwin and Vale, 2010, Müller et al., 2010, Swaminathan et al., 2010, Peel et al., 2007)
          Sas4
          (Alzyoud et al., 2024, Pimenta-Marques et al., 2024, Villars et al., 2022, Szikora et al., 2021, Dobbelaere et al., 2020, Gartenmann et al., 2020, Lapart et al., 2020, Persico et al., 2020, Persico et al., 2019, McLamarrah et al., 2018, Dzhindzhev et al., 2017, Galletta et al., 2016, Gottardo et al., 2016, Vieillard et al., 2015, Winkler et al., 2015, Dzhindzhev et al., 2014, Oliveira and Nasmyth, 2013, Guha et al., 2008)
          d-SAS-4
          (Hsu et al., 2008)
          dCPAP
          (Cottee et al., 2013)
          dsas-4
          (Wang et al., 2011, Januschke and Gonzalez, 2010, Castellanos et al., 2008)
          l(3)S2214
          (Provost et al., 2006)
          l(3)s2214
          (Gresens and Cook, 2006.12.5)
          sas-4
          (Cunningham et al., 2022, Hannaford et al., 2022, Zheng et al., 2020, Dewey and Johnston, 2017, Poulton et al., 2017, Caous et al., 2015, Poulton et al., 2014, Jauffred et al., 2013, Gopalakrishnan et al., 2011, Müller et al., 2010, Blachon et al., 2009)
          sas4
          (Loh et al., 2023, Goupil et al., 2022, Braun et al., 2021, Lapart et al., 2019, Loyer and Januschke, 2018, Carvajal-Gonzalez et al., 2016, Galletta et al., 2016, Saurya et al., 2016, Novak et al., 2014, Enjolras et al., 2012)
          Name Synonyms
          DSas-4
          (Somma et al., 2008)
          Drosophila Sas-4
          (Basto et al., 2006)
          Spindle assembly abnormal 4
          Spindle assembly abnormal 4 ortholog
          Spindle assembly abnormal 4 orthologue
          (Homem et al., 2015)
          Secondary FlyBase IDs
          • FBgn0037480
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 33 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          PDB - An information portal to biological macromolecular structures
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          References (198)