FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\mamo
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General Information
Symbol
Dmel\mamo
Species
D. melanogaster
Name
maternal gene required for meiosis
Annotation Symbol
CG45477
Feature Type
protein_coding_gene
FlyBase ID
FBgn0267033
Gene Model Status
Current
Stock Availability
82 publicly available
Gene Summary
maternal gene required for meiosis (mamo) encodes a zinc finger C2H2 transcription factor enriched in embryonic primordial germ cells. It is required for functional gamete production. [Date last reviewed: 2019-06-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

lincRNA.990

Key Links
Genomic Location
Cytogenetic map
12C7-12D1
Sequence location
Recombination map
1-47
RefSeq locus
NC_004354 REGION:13846116..13990527
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from direct assay
(Hira et al., 2013)
enables sequence-specific DNA binding
inferred from direct assay
(Hira et al., 2013)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in female meiotic nuclear division
inferred from mutant phenotype
(Mukai et al., 2007)
involved_in gamete generation
inferred from mutant phenotype
(Mukai et al., 2007)
involved_in regulation of chromatin organization
inferred from mutant phenotype
(Hira et al., 2013)
involved_in regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Mukai et al., 2007)
involved_in sperm DNA decondensation
inferred from mutant phenotype
(Mukai et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001135010
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Mukai et al., 2007)
located_in nuclear chromosome
inferred from direct assay
(Singari et al., 2014)
located_in nucleus
inferred from direct assay
(Hira et al., 2013, Mukai et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001135010
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
maternal gene required for meiosis (mamo) encodes a zinc finger C2H2 transcription factor enriched in embryonic primordial germ cells. It is required for functional gamete production. [Date last reviewed: 2019-06-13]
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Summary (Interactive Fly)

BTB transcription factor - essential for the temporally defined, terminal identity of alpha'/beta' mushroom body neurons and identity maintenance - required for the production of functional oocytes - necessary for vasa expression

Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\mamo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VY72)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mamo-RC
FBtr0346007
NM_001103508
4583
799
mamo-RD
FBtr0346004
NM_001272610
5359
1087
mamo-RE
FBtr0346003
NM_001201660
15683
1087
mamo-RF
FBtr0346005
NM_001258733
4535
1109
mamo-RG
FBtr0346006
NM_001258732
8765
1109
mamo-RH
FBtr0346002
NM_167387
9885
1553
mamo-RI
FBtr0346001
NM_132704
14402
1553
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
mamo-PC
FBpp0311886
82.7
799
4.50
H1UUK0
NP_001096978
AAF48335
mamo-PD
FBpp0311883
111.1
1087
5.01
M9PJM9
NP_001259539
AGB95381
mamo-PE
FBpp0311882
111.1
1087
5.01
M9PJM9
NP_001188589
ADV37671
mamo-PF
FBpp0311884
113.5
1109
5.12
M9NEG1
NP_001245662
AFH07376
mamo-PG
FBpp0311885
113.5
1109
5.12
M9NEG1
NP_001245661
AFH07375
mamo-PH
FBpp0311881
162.4
1553
6.03
Q9VY72
NP_727743
AAF48333
mamo-PI
FBpp0311880
162.4
1553
6.03
Q9VY72
NP_572932
AAF48332
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1553 aa isoforms: mamo-PH, mamo-PI
1087 aa isoforms: mamo-PD, mamo-PE
1109 aa isoforms: mamo-PF, mamo-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mamo using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.98

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval crystal cell
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Mukai et al., 2007)
located_in nuclear chromosome
inferred from direct assay
(Singari et al., 2014)
located_in nucleus
inferred from direct assay
(Hira et al., 2013, Mukai et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mamo in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 34 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mamo
Transgenic constructs containing regulatory region of mamo
Aberrations (Deficiencies and Duplications) ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Mef2.PR
lethal, with Scer\GAL4pnr-MD237
lethal | germline clone | late embryonic stage
lethal | third instar larval stage
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
female sterile | germline clone
sterile
Other Phenotypes
Allele
abnormal meiotic cell cycle | female
abnormal neuroanatomy | P-stage, with Scer\GAL4c305a
abnormal neuroanatomy | P-stage | somatic clone
abnormal neuroanatomy | pupal stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.Tag:NLS(Unk)
decreased fecundity | female | germline clone
increased mortality during development | germline clone | maternal effect, with Scer\GAL4VP16.nanos.UTR, mamos-MZD.UASp.Tag:FLAG
increased mortality during development | germline clone | maternal effect, with Scer\GAL4VP16.nanos.UTR, mamoSVA53
majority die during embryonic stage | germline clone | maternal effect, with Scer\GAL4VP16.nanos.UTR, mamos-MZD.UASp.Tag:FLAG
majority die during embryonic stage | germline clone | maternal effect, with Scer\GAL4VP16.nanos.UTR, mamoSVA53
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4Bx-MS1096-KE
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4GMR.PF
Phenotype manifest in
Allele
adult Kenyon cell | P-stage, with Scer\GAL4c305a
adult Kenyon cell | P-stage | somatic clone
axon | P-stage, with Scer\GAL4c305a
axon | P-stage | somatic clone
axon | pupal stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.Tag:NLS(Unk)
chaeta | increased number, with Scer\GAL4pnr-MD237
chromatin, with Scer\GAL4VP16.nanos.UTR
chromatin | germline clone
chromatin | heat sensitive, with Scer\GAL4hs.PB
egg | germline clone
egg chamber | germline clone
embryonic/larval fat body | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
extracellular matrix | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PF
gamma Kenyon cell | pupal stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.Tag:NLS(Unk)
polytene chromosome | germline clone
polytene chromosome | heat sensitive, with Scer\GAL4hs.PB
primordial germ cell
synaptonemal complex
wing, with Scer\GAL4Bx-MS1096-KE
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (89)
Hsap\BTBD18
2 of 14
Yes
No
Hsap\KBTBD4
2 of 14
Yes
Yes
Hsap\ABTB1
1 of 14
No
Yes
Hsap\BCL6B
1 of 14
No
Yes
Hsap\EGR2
1 of 14
No
No
1  
Hsap\EGR3
1 of 14
No
No
Hsap\KBTBD2
1 of 14
No
No
Hsap\KBTBD3
1 of 14
No
No
Hsap\KLF1
1 of 14
No
No
Hsap\KLF3
1 of 14
No
No
1  
Hsap\KLF8
1 of 14
No
No
Hsap\KLF11
1 of 14
No
No
Hsap\KLF15
1 of 14
No
No
1  
Hsap\KLHL2
1 of 14
No
No
Hsap\KLHL3
1 of 14
No
No
Hsap\KLHL12
1 of 14
No
No
Hsap\KLHL15
1 of 14
No
No
Hsap\KLHL17
1 of 14
No
No
Hsap\KLHL20
1 of 14
No
No
Hsap\KLHL21
1 of 14
No
No
Hsap\KLHL23
1 of 14
No
No
Hsap\KLHL24
1 of 14
No
No
Hsap\KLHL26
1 of 14
No
No
Hsap\KLHL30
1 of 14
No
No
Hsap\KLHL31
1 of 14
No
No
Hsap\KLHL36
1 of 14
No
No
Hsap\MYNN
1 of 14
No
No
Hsap\PHOSPHO2-KLHL23
1 of 14
No
No
Hsap\SALL3
1 of 14
No
No
Hsap\SP1
1 of 14
No
No
0  
Hsap\SP2
1 of 14
No
No
Hsap\SP3
1 of 14
No
No
0  
Hsap\SP4
1 of 14
No
No
Hsap\SP7
1 of 14
No
No
Hsap\SP8
1 of 14
No
No
Hsap\SP9
1 of 14
No
No
Hsap\ZBTB6
1 of 14
No
No
Hsap\ZBTB7A
1 of 14
No
No
1  
Hsap\ZBTB7C
1 of 14
No
Yes
Hsap\ZBTB9
1 of 14
No
No
Hsap\ZBTB12
1 of 14
No
Yes
Hsap\ZBTB14
1 of 14
No
No
Hsap\ZBTB17
1 of 14
No
Yes
Hsap\ZBTB20
1 of 14
No
No
Hsap\ZBTB21
1 of 14
No
No
Hsap\ZBTB24
1 of 14
No
No
1  
Hsap\ZBTB26
1 of 14
No
Yes
Hsap\ZBTB34
1 of 14
No
Yes
Hsap\ZBTB37
1 of 14
No
No
Hsap\ZBTB41
1 of 14
No
No
Hsap\ZBTB44
1 of 14
No
No
Hsap\ZBTB47
1 of 14
No
No
Hsap\ZFP28
1 of 14
No
No
Hsap\ZNF17
1 of 14
No
No
Hsap\ZNF22
1 of 14
No
No
Hsap\ZNF45
1 of 14
No
No
Hsap\ZNF112
1 of 14
No
No
Hsap\ZNF131
1 of 14
No
No
Hsap\ZNF134
1 of 14
No
Yes
Hsap\ZNF184
1 of 14
No
No
Hsap\ZNF208
1 of 14
No
No
Hsap\ZNF225
1 of 14
No
No
Hsap\ZNF233
1 of 14
No
No
Hsap\ZNF333
1 of 14
No
Yes
Hsap\ZNF347
1 of 14
No
No
Hsap\ZNF354B
1 of 14
No
No
Hsap\ZNF420
1 of 14
No
No
Hsap\ZNF436
1 of 14
No
No
Hsap\ZNF460
1 of 14
No
No
Hsap\ZNF480
1 of 14
No
No
Hsap\ZNF510
1 of 14
No
No
Hsap\ZNF524
1 of 14
No
No
Hsap\ZNF527
1 of 14
No
No
Hsap\ZNF534
1 of 14
No
No
Hsap\ZNF551
1 of 14
No
No
Hsap\ZNF574
1 of 14
No
No
Hsap\ZNF629
1 of 14
No
No
Hsap\ZNF652
1 of 14
No
Yes
Hsap\ZNF682
1 of 14
No
No
Hsap\ZNF696
1 of 14
No
Yes
Hsap\ZNF768
1 of 14
No
No
Hsap\ZNF777
1 of 14
No
No
Hsap\ZNF808
1 of 14
No
No
Hsap\ZNF845
1 of 14
No
No
Hsap\ZNF880
1 of 14
No
No
Hsap\ZSCAN2
1 of 14
No
No
Hsap\ZSCAN16
1 of 14
No
No
Hsap\ZSCAN22
1 of 14
No
No
Hsap\ZSCAN23
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (34)
Rnor\Btbd18
2 of 14
Yes
No
Rnor\Kbtbd4
2 of 14
Yes
Yes
Rnor\Abtb1
1 of 14
No
Yes
Rnor\Ikzf1
1 of 14
No
No
Rnor\Kbtbd3
1 of 14
No
No
Rnor\Klf8
1 of 14
No
No
Rnor\Klhl2
1 of 14
No
No
Rnor\Klhl12
1 of 14
No
No
Rnor\Klhl15
1 of 14
No
No
Rnor\Klhl20
1 of 14
No
No
Rnor\Klhl21
1 of 14
No
No
Rnor\Klhl24
1 of 14
No
No
Rnor\Klhl26
1 of 14
No
No
Rnor\Klhl40
1 of 14
No
No
Rnor\Nacc2
1 of 14
No
No
Rnor\Sp2
1 of 14
No
No
Rnor\Sp3
1 of 14
No
No
Rnor\Sp8
1 of 14
No
No
Rnor\Sp9
1 of 14
No
No
Rnor\Zbtb9
1 of 14
No
Yes
Rnor\Zbtb20
1 of 14
No
No
Rnor\Zbtb24
1 of 14
No
Yes
Rnor\Zbtb37
1 of 14
No
No
Rnor\Zbtb41
1 of 14
No
No
Rnor\Zbtb43
1 of 14
No
No
Rnor\Zfp35
1 of 14
No
No
Rnor\Zfp131
1 of 14
No
No
Rnor\Zfp161
1 of 14
No
No
Rnor\Zfp251
1 of 14
No
Yes
Rnor\Zfp647
1 of 14
No
No
Rnor\Zim1
1 of 14
No
Yes
Rnor\Zkscan2
1 of 14
No
No
Rnor\Zkscan4
1 of 14
No
No
Rnor\Znf768
1 of 14
No
Yes
Mus musculus (laboratory mouse) (32)
Mmus\Btbd18
2 of 14
Yes
Yes
Mmus\Kbtbd4
2 of 14
Yes
Yes
Mmus\Abtb1
1 of 14
No
Yes
Mmus\Gzf1
1 of 14
No
Yes
Mmus\Kbtbd3
1 of 14
No
No
Mmus\Klf8
1 of 14
No
No
Mmus\Klhl2
1 of 14
No
No
Mmus\Klhl3
1 of 14
No
No
Mmus\Klhl12
1 of 14
No
No
Mmus\Klhl15
1 of 14
No
No
Mmus\Klhl20
1 of 14
No
No
Mmus\Klhl21
1 of 14
No
No
Mmus\Klhl24
1 of 14
No
No
Mmus\Klhl40
1 of 14
No
No
Mmus\Sp2
1 of 14
No
No
Mmus\Sp3
1 of 14
No
No
Mmus\Sp8
1 of 14
No
No
1  
Mmus\Sp9
1 of 14
No
No
Mmus\Yy2
1 of 14
No
No
Mmus\Zbtb9
1 of 14
No
Yes
Mmus\Zbtb14
1 of 14
No
Yes
Mmus\Zbtb17
1 of 14
No
No
Mmus\Zbtb20
1 of 14
No
Yes
Mmus\Zbtb24
1 of 14
No
Yes
Mmus\Zbtb37
1 of 14
No
Yes
Mmus\Zbtb43
1 of 14
No
Yes
Mmus\Zfp35
1 of 14
No
No
Mmus\Zfp282
1 of 14
No
Yes
Mmus\Zfp647
1 of 14
No
No
Mmus\Zfp768
1 of 14
No
No
Mmus\Zim1
1 of 14
No
Yes
Mmus\Zkscan4
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (46)
Xtro\btbd18
2 of 13
Yes
Yes
Xtro\abtb1
1 of 13
No
No
Xtro\bcl6
1 of 13
No
Yes
Xtro\cdkl5
1 of 13
No
No
Xtro\kbtbd2
1 of 13
No
No
Xtro\klf4
1 of 13
No
No
Xtro\klf10
1 of 13
No
No
Xtro\klf15.2
1 of 13
No
No
Xtro\klf15
1 of 13
No
No
Xtro\klhl2
1 of 13
No
No
Xtro\klhl21
1 of 13
No
No
Xtro\klhl22
1 of 13
No
No
Xtro\klhl23
1 of 13
No
No
Xtro\klhl24
1 of 13
No
No
Xtro\klhl28
1 of 13
No
No
Xtro\klhl36
1 of 13
No
No
Xtro\klhl40
1 of 13
No
No
Xtro\LOC100485218
1 of 13
No
No
Xtro\LOC100495895
1 of 13
No
No
Xtro\LOC100496074
1 of 13
No
No
Xtro\LOC100496285
1 of 13
No
No
Xtro\LOC101731131
1 of 13
No
Yes
Xtro\LOC101731232
1 of 13
No
No
Xtro\LOC101732880
1 of 13
No
No
Xtro\LOC101733761
1 of 13
No
No
Xtro\prdm15
1 of 13
No
Yes
Xtro\sall1
1 of 13
No
No
Xtro\sp3
1 of 13
No
No
Xtro\sp4
1 of 13
No
No
Xtro\sp8
1 of 13
No
No
Xtro\sp9
1 of 13
No
No
Xtro\vps28
1 of 13
No
No
Xtro\XB5772961
1 of 13
No
Yes
Xtro\zbtb6
1 of 13
No
Yes
Xtro\zbtb11
1 of 13
No
No
Xtro\zbtb12
1 of 13
No
Yes
Xtro\zbtb14
1 of 13
No
Yes
Xtro\zbtb20
1 of 13
No
Yes
Xtro\zbtb21
1 of 13
No
Yes
Xtro\zbtb37
1 of 13
No
No
Xtro\zbtb41
1 of 13
No
No
Xtro\zbtb43
1 of 13
No
No
Xtro\znf329
1 of 13
No
No
Xtro\znf568
1 of 13
No
No
Xtro\znf574
1 of 13
No
No
Xtro\znf628
1 of 13
No
No
Danio rerio (Zebrafish) (46)
Drer\abtb1
1 of 14
Yes
Yes
Drer\bach1a
1 of 14
Yes
Yes
Drer\gan
1 of 14
Yes
No
Drer\hivep2b
1 of 14
Yes
No
Drer\kbtbd3
1 of 14
Yes
No
Drer\klf1
1 of 14
Yes
No
Drer\klf2a
1 of 14
Yes
No
Drer\klf5a
1 of 14
Yes
No
Drer\klhl7
1 of 14
Yes
No
Drer\klhl10a
1 of 14
Yes
No
Drer\klhl12
1 of 14
Yes
No
Drer\klhl15
1 of 14
Yes
No
Drer\klhl17
1 of 14
Yes
No
Drer\klhl20
1 of 14
Yes
No
Drer\klhl21
1 of 14
Yes
No
Drer\klhl22
1 of 14
Yes
No
Drer\klhl24b
1 of 14
Yes
No
Drer\klhl26
1 of 14
Yes
No
Drer\klhl35
1 of 14
Yes
No
Drer\klhl36
1 of 14
Yes
No
Drer\klhl40a
1 of 14
Yes
No
Drer\klhl40b
1 of 14
Yes
No
Drer\klhl41b
1 of 14
Yes
No
Drer\LOC100006216
1 of 14
Yes
Yes
Drer\LOC101884367
1 of 14
Yes
No
Drer\LOC108178999
1 of 14
Yes
No
Drer\LOC108182318
1 of 14
Yes
No
Drer\LOC108183930
1 of 14
Yes
No
Drer\sall1a
1 of 14
Yes
No
Drer\si:cabz01032454.3
1 of 14
Yes
No
Drer\si:dkey-7l6.3
1 of 14
Yes
Yes
Drer\sp1
1 of 14
Yes
No
Drer\sp2
1 of 14
Yes
No
Drer\sp3a
1 of 14
Yes
No
Drer\sp3b
1 of 14
Yes
No
Drer\sp5b
1 of 14
Yes
No
Drer\sp5l
1 of 14
Yes
No
Drer\sp7
1 of 14
Yes
No
Drer\sp8a
1 of 14
Yes
No
Drer\sp8b
1 of 14
Yes
No
Drer\sp9
1 of 14
Yes
No
Drer\zbtb14
1 of 14
Yes
Yes
Drer\zbtb20
1 of 14
Yes
No
Drer\zbtb24
1 of 14
Yes
Yes
Drer\znf865
1 of 14
Yes
No
Drer\znf1177
1 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\egrh-1
1 of 14
Yes
No
Cele\eor-1
1 of 14
Yes
No
Cele\kel-3
1 of 14
Yes
No
Cele\kel-20
1 of 14
Yes
No
Cele\sptf-3
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (42)
Agam\AgaP_AGAP000585
5 of 12
Yes
Yes
Agam\AgaP_AGAP000080
3 of 12
No
No
Agam\AgaP_AGAP000587
3 of 12
No
Yes
Agam\AgaP_AGAP003189
3 of 12
No
No
Agam\AgaP_AGAP001073
2 of 12
No
No
Agam\AgaP_AGAP001646
2 of 12
No
No
Agam\AgaP_AGAP002297
2 of 12
No
No
Agam\AgaP_AGAP003286
2 of 12
No
No
Agam\AgaP_AGAP003439
2 of 12
No
No
Agam\AgaP_AGAP003537
2 of 12
No
No
Agam\AgaP_AGAP003685
2 of 12
No
No
Agam\AgaP_AGAP005245
2 of 12
No
No
Agam\AgaP_AGAP005747
2 of 12
No
No
Agam\AgaP_AGAP008031
2 of 12
No
No
Agam\AgaP_AGAP008506
2 of 12
No
Yes
Agam\AgaP_AGAP008959
2 of 12
No
No
Agam\AgaP_AGAP010063
2 of 12
No
No
Agam\AgaP_AGAP010355
2 of 12
No
No
Agam\AgaP_AGAP011247
2 of 12
No
No
Agam\AgaP_AGAP011583
2 of 12
No
No
Agam\AgaP_AGAP000673
1 of 12
No
No
Agam\AgaP_AGAP000674
1 of 12
No
No
Agam\AgaP_AGAP000779
1 of 12
No
No
Agam\AgaP_AGAP001258
1 of 12
No
Yes
Agam\AgaP_AGAP002163
1 of 12
No
No
Agam\AgaP_AGAP002164
1 of 12
No
Yes
Agam\AgaP_AGAP002165
1 of 12
No
No
Agam\AgaP_AGAP003364
1 of 12
No
No
Agam\AgaP_AGAP003428
1 of 12
No
No
Agam\AgaP_AGAP003645
1 of 12
No
No
Agam\AgaP_AGAP004517
1 of 12
No
No
Agam\AgaP_AGAP005244
1 of 12
No
No
Agam\AgaP_AGAP005748
1 of 12
No
No
Agam\AgaP_AGAP006018
1 of 12
No
No
Agam\AgaP_AGAP006454
1 of 12
No
No
Agam\AgaP_AGAP008362
1 of 12
No
No
Agam\AgaP_AGAP009641
1 of 12
No
No
Agam\AgaP_AGAP009889
1 of 12
No
No
Agam\AgaP_AGAP011142
1 of 12
No
No
Agam\AgaP_AGAP011902
1 of 12
No
No
Agam\AgaP_AGAP012550
1 of 12
No
No
Agam\AgaP_AGAP013477
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\AT4G08455
1 of 13
Yes
No
Atha\YY1
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\CMR3
1 of 13
Yes
No
Scer\YPR015C
1 of 13
Yes
Yes
Scer\ZAP1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:mamo. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (39)
ab
5 of 13
CG6118
5 of 13
CG34376
5 of 13
fru
5 of 13
tono
5 of 13
bab1
4 of 13
bab2
4 of 13
br
4 of 13
CG3726
4 of 13
CG6765
4 of 13
CG8924
4 of 13
CG12236
4 of 13
chinmo
4 of 13
lolal
4 of 13
lola
4 of 13
lov
4 of 13
Trl
4 of 13
ttk
4 of 13
BtbVII
3 of 13
mod(mdg4)
3 of 13
psq
3 of 13
rib
3 of 13
CG15812
2 of 13
btd
1 of 13
cbt
1 of 13
CG3065
1 of 13
CG7987
1 of 13
CG9426
1 of 13
CG12391
1 of 13
CG15097
1 of 13
CG30431
1 of 13
gl
1 of 13
her
1 of 13
hkb
1 of 13
ken
1 of 13
pre-lola-G
1 of 13
rdx
1 of 13
seq
1 of 13
Zif
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    mamo
    enhanceable
    HDAC1
    (Nakamura et al., 2020)
    mamo
    enhanceable
    nej
    (Nakamura et al., 2020)
    mamo
    suppressible
    Sema1a
    (Chu et al., 2024)
    mamo
    enhanceable
    Taf3
    (Nakamura et al., 2020)
    mamo
    enhanceable
    Trf2
    (Nakamura et al., 2020)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    nej
    enhanceable
    mamo
    (Nakamura et al., 2020)
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-47
    Cytogenetic map
    12C7-12D1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    12C7-12D1
    Limits computationally determined from genome sequence between P{EP}CG33174EP1101 and P{EP}EP1595EP1595
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    1-47

    (FlyBase, 2016)

    1-44.4

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (82)
    Genomic Clones (57)
    cDNA Clones (15)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Rossi and Desplan, 2020, Alyagor et al., 2018)
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        New annotation (CR44656) in release 5.51 of the genome annotation.

        (FlyBase Genome Annotators, 2013)

        When dsRNA made from templates generated with primers directed against this gene.

        (Mukai et al., 2007)

        New annotation (CG32606) in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: mamo CG11071

        (FlyBase Genome Annotators, 2012)

        Source for merge of: mamo CG32606

        (FlyBase Genome Annotators, 2011)

        Source for merge of: CG11072 CG32611

        (FlyBase Genome Annotators, 2007)

        Source for merge of: mamo CR44656

        (FlyBase Genome Annotators, 2014)
        Additional comments

        Annotations CR44656 and CG44132 merged as CG45477 in release 5.56 of the genome annotation. Merge supported by similar modENCODE RNA-Seq temporal expression profiles, as well as junction from RAMPAGE RNA-Seq (FBrf0220331).

        (FlyBase Genome Annotators, 2014)

        Annotations CG34346 and CG11071 merged as CG44132 in release 5.47 of the genome annotation. Merge supported by RNA-seq junction data.

        (FlyBase Genome Annotators, 2012)

        Annotation CG32606 merged with annotation CG34346 in release 5.36 of the genome annotation; CG32606 corresponds to 5' UTR of CG34346.

        (FlyBase Genome Annotators, 2011)

        Annotations CG11072 and CG32611 merged as CG34346 in release 5.2 of the genome annotation.

        (FlyBase Genome Annotators, 2007)

        Annotations CG11075, CG11082 merged as CG32611 in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)
        Nomenclature History
        Source for database identify of

        Source for identity of: mamo CG34346

        (Mukai et al., 2007)
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (14)
        Reported As
        Symbol Synonym
        CG11071
        (Sebastian et al., 2022, Sarov et al., 2016, McEachern et al., 2014, Singari et al., 2014, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Mukai et al., 2007, Alekseyenko et al., 2006)
        CG11072
        (Hoskins et al., 2005)
        CG11075
        CG11082
        CG32606
        (Keleman et al., 2009.8.5, Turner et al., 2008)
        CG32611
        (Maeng et al., 2012, Junion et al., 2007, Hoskins et al., 2005, Nelson et al., 2005)
        CG34346
        (Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2007)
        CG44132
        (FlyBase Genome Annotators, 2012, Ni et al., 2010.12.1, Perkins et al., 2009)
        CG45477
        (National Institute of Genetics Fly Stocks, 2023-, FlyBase Genome Annotators, 2014)
        CR44656
        (FlyBase Genome Annotators, 2013)
        Mamo
        (Islam and Erclik, 2022, Pfeifer et al., 2022, Nakamura et al., 2020, Rust et al., 2020, Nakamura et al., 2019)
        lincRNA.990
        (FlyBase Genome Annotators, 2014, Young et al., 2012)
        mamo
        (Alizada et al., 2025, Hu et al., 2025, Lee et al., 2025, Shun Li et al., 2025, Bonchuk et al., 2024, Chu et al., 2024, Zhang et al., 2024, Floc'hlay et al., 2023, Guan et al., 2022, Saha et al., 2022, Hall et al., 2021, McLaughlin et al., 2021, Michki et al., 2021, Slaidina et al., 2021, Winbush and Singh, 2021, Xie et al., 2021, Hung et al., 2020, Samuels et al., 2020, Campbell et al., 2019, Meltzer et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Croset et al., 2018, Davie et al., 2018, Hu et al., 2017.6.13, McMahon et al., 2016, Duff et al., 2015, Schertel et al., 2015, Ashwal-Fluss et al., 2014, Singari et al., 2014, Hira et al., 2013, FlyBase Genome Annotators, 2011, Luo et al., 2011, Popodi et al., 2010-, Mukai et al., 2007)
        Name Synonyms
        CG11072
        CG32611
        maternal gene required for meiosis
        (McEachern et al., 2014)
        Secondary FlyBase IDs
        • FBgn0030532
        • FBgn0052611
        • FBgn0030535
        • FBgn0030533
        • FBgn0030534
        • FBgn0085375
        • FBgn0052606
        • FBgn0263115
        • FBgn0264981
        • FBgn0265867
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 60 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        References (111)