FlyBase Allele Report: Mmus\Prkaca[mC.UAS]

General Information

Symbol

Mmus\Prkaca^mC.UAS

Species

M. musculus

Name

FlyBase ID

FBal0058457

Feature type

allele

Associated gene

Mmus\Prkaca

Associated Insertion(s)

Carried in Construct

P{UAS-PKA.mC}

Also Known As

UAS-mC*, UAS-PKA^CA, UAS-PKAact¹, UAS-mc^*, UAS-PKAmc*, UAS-PKA-mc*, mC*

Transgenic product class

missense_variant

(Li et al., 1995)

Mutagen

FLPase

Nature of the Allele

Transgenic product class

missense_variant

(Li et al., 1995)

Mutagen

FLPase

(Li et al., 1995)

Progenitor genotype

Mmus\Prkaca^mC.FRT.UAS

(Li et al., 1995)

Carried in construct

P{UAS-PKA.mC}

Cytology

Description

The FRT cassette has been excised, allowing UAS regulatory sequences to drive expression of a constitutively active form of Mmus\Prkaca ('mC*', contains the amino acid replacements H87Q and W196R).

(Li et al., 1995)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mmus\Prkaca

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurofibromatosis

modeled by Nf1^E2

(Walker et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior, with Scer\GAL4^30Y

(Joiner et al., 2006)

abnormal behavior, with Scer\GAL4^238Y

(Joiner et al., 2006)

abnormal behavior, with Scer\GAL4^c309

(Joiner et al., 2006)

abnormal behavior, with Scer\GAL4^Tab2-201Y

(Joiner et al., 2006)

abnormal behavior | heat sensitive, with Scer\GAL4^c309

(Pitman et al., 2006)

abnormal behavior | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Joiner et al., 2006)

abnormal behavior | RU486 conditional, with Scer\GAL4^{Mef2.247.Switch}

(Joiner et al., 2006)

abnormal developmental rate, with Scer\GAL4^{Itpr-1664GAL4}

(Venkatesh et al., 2001)

abnormal mating behavior | female, with Scer\GAL4^ppk.PG

(Yang et al., 2009)

abnormal neuroanatomy, with Scer\GAL4^G14

(Sulkowski et al., 2014)

abnormal neurophysiology, with Scer\GAL4^eve.RN2

(Baines, 2004)

abnormal neurophysiology, with Scer\GAL4^eve.RN2O

(Baines, 2003)

abnormal neurophysiology, with Scer\GAL4^Mhc.PW

(Davis et al., 1998)

abnormal sleep, with Scer\GAL4^104Y

(Liu et al., 2012)

abnormal temperature response | adult stage, with Scer\GAL4^Mef2.247

(Kang et al., 2011)

abnormal thermotaxis | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Hong et al., 2008)

abnormal visual behavior, with Scer\GAL4^ninaE.PD

(Chyb et al., 1999)

abnormal wound healing | third instar larval stage, with Scer\GAL4^tey-5053A

(Hao et al., 2016)

increased cell death, with Scer\GAL4^en-e16E

(Kimura et al., 2004)

increased cell growth rate | third instar larval stage | conditional, with Scer\GAL4^tey-5053A

(Hao et al., 2016)

lethal, with Scer\GAL4^Act5C.PU

(Walker et al., 2013)

lethal, with Scer\GAL4^ap-md544

(Cheng et al., 2012)

lethal, with Scer\GAL4^elav.PU

(Walker et al., 2013)

visible, with Scer\GAL4^en-e16E

(Kimura et al., 2004)

Phenotype Manifest In

actin cytoskeleton, with Scer\GAL4^moody.PS

(Li et al., 2021)

apical plasma membrane | larval stage, with Scer\GAL4^moody.PS

(Li et al., 2021)

axon | third instar larval stage | conditional, with Scer\GAL4^tey-5053A

(Hao et al., 2016)

embryonic/larval subperineurial glial cell | larval stage, with Scer\GAL4^moody.PS

(Li et al., 2021)

larval DA1 motor neuron, with Scer\GAL4^eve.RN2O

(Baines, 2003)

larval RP2 motor neuron, with Scer\GAL4^eve.RN2O

(Baines, 2003)

motor neuron | third instar larval stage | conditional, with Scer\GAL4^tey-5053A

(Hao et al., 2016)

neuromuscular junction | third instar larval stage, with Scer\GAL4^elav-C155

(Cho et al., 2015)

nurse cell, with Scer\GAL4^nanos.PG

(Jackson and Berg, 2002)

nurse cell, with Scer\GAL4^{VP16.nanos.UTR}

(Jackson and Berg, 2002)

perineurium | larval stage, with Scer\GAL4^moody.PS

(Li et al., 2021)

photoreceptor neuron, with Scer\GAL4^ninaE.PD

(Chyb et al., 1999)

septate junction | larval stage, with Scer\GAL4^moody.PS

(Li et al., 2021)

subperineurial glial cell, with Scer\GAL4^moody.PS

(Li et al., 2021)

terminal bouton, with Scer\GAL4^G14

(Sulkowski et al., 2014)

ventral denticle belt | posterior, with Scer\GAL4^e22c

(Ohlmeyer and Kalderon, 1997)

wing, with Scer\GAL4^en-e16E

(Kimura et al., 2004)

wing | pharate adult stage, with Scer\GAL4^en-e16E

(Kimura et al., 2004)

wing disc, with Scer\GAL4^71B

(Price and Kalderon, 1999)

Detailed Description

Statement

Reference

Expression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^tey-5053A leads to an enhanced growth response of motoneuron axons after nerve crush injury in third instar larvae, as compared to wild type.

(Hao et al., 2016)

Third instar larvae expressing Mmus\Prkaca^mC.UAS under the control of Scer\GAL4^elav-C155 exhibit enhanced synaptic growth (increased number of boutons) at the neuromuscular junctions.

(Cho et al., 2015)

The class IV dendritic arborization neurons in flies expressing Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^ppk.PG show a significant decrease in the complexity of dendritic arbors in respect to the total dendritic length. The total number of dendritic branching points is also decreased. This phenotype is dose-dependent: a greater loss of complexity is seen when one copy of Mmus\Pkaca^mC.Scer\UAS is expressed at 29[o]C compared with 25[o], and expression of two copies of Mmus\Pkaca^mC.Scer\UAS at 25[o]C causes even greater arbor simplification, with the arbors growing only minimal primary branches. These hypotrophic branches often end with a stump at the tip, indicating possible impairment of dendritic growth cone progression.

The overall microtubule structure appears normal and polarity is similar to wild type.

There are significantly fewer golgi outposts in the distal arbor compartments compared to wild type. The distribution of early endosomes is altered compared to wild type and the number of endosomes in the distal compartments is significantly lower.

(Copf, 2014)

Expression of GluRIIC^JF01854 under the control of Scer\GAL4^G14 results in a significant reduction in bouton number at muscle 4 NMJs compared to controls. No significant difference is seen in muscle 6/7 NMJs.

(Sulkowski et al., 2014)

Expression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^ap-md544 is lethal.

(Cheng et al., 2012)

Flies expressing Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^104Y show reduced night-time sleep compared to controls.

(Liu et al., 2012)

Flies expressing Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^Mef2.247 show altered temperature preference behaviour compared to wild type: the avoidance index for high temperature is significantly reduced compared to wild type.

(Kang et al., 2011)

Mated females expressing Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^ppk.PG show higher levels of sexual receptivity than control mated females. The rate of egg-laying of the mutant mated females is not significantly different from that of control mated females.

(Yang et al., 2009)

After 24 hours of feeding with RU486, flies expressing Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^{elav.Switch.PO} show decreased avoidance of high temperature, but not low temperature.

Flies expressing Pka-R1^BDK.Scer\UAS under the control of either Scer\GAL4^Mef2.247 or Scer\GAL4^c747 (restricted to 16 hours expression from day three of adulthood onwards using Scer\GAL80^ts.αTub84B) show a shift in temperature preference from 24[o]C to 27[o]C.

(Hong et al., 2008)

Expression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^{elav.Switch.PO} (induced using RU486) decreases daily sleep.

Expression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^Tab2-201Y results in an increase in total daily sleep compared to controls. The adults flies have normal waking activity.

Expression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^c309 results in an decrease in total daily sleep compared to controls. Activity normalised to waking time is not significantly higher than controls.

Expression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^30Y or Scer\GAL4^238Y promotes sleep during the day, but inhibits sleep during the night.

Expression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^{Mef2.247.Switch} (in the presence of RU486) results in a reduction in sleep, due to a shortened sleep bout duration without a concomitant increase in the sleep bout number. When RU486 is withdrawn after about three days of sleep deprivation, these flies show a robust sleep rebound response.

(Joiner et al., 2006)

Expression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^c309 results in reduced sleep compared to controls.

(Pitman et al., 2006)

Postsynaptic expression of Mmus\Pkaca^mC.Scer\UAS, under the control of Scer\GAL4^eve.RN2, results in the averaged amplitude of synaptic currents recorded from whole-cell voltage clamp recordings of aCC/RP2 motoneurons being significantly increased compared with controls.

(Baines, 2004)

Mmus\Pkaca^mC.Scer\UAS; Scer\GAL4^en-e16E adults have blistered wings. There is precocious cell of wing blade cells in late stage pharate adults (G+; <3hrs before eclosion) of this genotype .

(Kimura et al., 2004)

The ability of aCC/RP2 to fire action potentials (APs) in response to an injection of constant current is decreased when Mmus\Pkaca^mC.Scer\UAS is constitutively expressed under the control of Scer\GAL4^eve.RN2O and there is also a decrease in peak current density of voltage-dependent inward Na⁺ current compared to wild type.

(Baines, 2003)

7.3% of egg chambers have at least one binucleate nurse cell in females expressing Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}. 3.1% of egg chambers have at least one binucleate nurse cell in females expressing Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^nos.PG.

(Jackson and Berg, 2002)

When expression is driven by Scer\GAL4^{Itp-r83A-1664GAL4} in an otherwise wild type background larval molting is delayed. Molting delay is most evident at the L2 to L3 transition. Feeding Mmus\Pkaca^mC.Scer\UAS,Scer\GAL4^{Itp-r83A-1664GAL4} larvae 20-hydroxyecdysone has no effect on the molting delay.

(Venkatesh et al., 2001)

When expression is driven by Scer\GAL4^ninaE.PD photoreceptors have slower macroscopic kinetics, similar to the effect caused by cAMP and IBMX.

(Chyb et al., 1999)

Expression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^71B results in a narrowing of the wing disc in the wing blade region.

(Price and Kalderon, 1999)

Overexpression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^Mhc.PW significantly decreases quantal size as estimated by the average spontaneous miniature excitatory junctional current or miniature excitatory junctional potential recorded in muscle 6 in the absence of nerve stimulation in larvae. The number of boutons at the neuromuscular junction of muscles 6 and 7 is normal in larvae expressing Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^Mhc.PW.

(Davis et al., 1998)

Embryos expressing Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^e22c give rise to larvae with abnormal denticle belts; the wide posterior denticle rows of each segment are replaced by narrower and often incomplete rows of denticles with different morphology and polarity from wild-type.

(Ohlmeyer and Kalderon, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Mmus\Prkaca^mC.UAS, Scer\GAL4^tey-5053A has abnormal wound healing | third instar larval stage phenotype, suppressible by wnd^GD13786, Scer\GAL4^tey-5053A

(Hao et al., 2016)

Mmus\Prkaca^mC.UAS, Scer\GAL4^tey-5053A has increased cell growth rate | third instar larval stage | conditional phenotype, suppressible by wnd^GD13786, Scer\GAL4^tey-5053A

(Hao et al., 2016)

Mmus\Prkaca^mC.UAS, Scer\GAL4^{Itpr-1664GAL4} has abnormal developmental rate phenotype, suppressible by Itpr^UAS.cVa, Scer\GAL4^{Itpr-1664GAL4}

(Venkatesh et al., 2001)

NOT suppressed by

Statement

Reference

Mmus\Prkaca^mC.UAS, Scer\GAL4^tey-5053A has abnormal wound healing | third instar larval stage phenotype, non-suppressible by moody^KK100674, Scer\GAL4^tey-5053A

(Hao et al., 2016)

Mmus\Prkaca^mC.UAS, Scer\GAL4^tey-5053A has increased cell growth rate | third instar larval stage | conditional phenotype, non-suppressible by moody^KK100674, Scer\GAL4^tey-5053A

(Hao et al., 2016)

Enhancer of

Statement

Reference

Mmus\Prkaca^mC.UAS, Scer\GAL4^ppk.PG is an enhancer of abnormal neuroanatomy phenotype of Rab5^S43N.UAS, Scer\GAL4^ppk.PG

(Copf, 2014)

Mmus\Prkaca^mC.UAS, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

Scer\GAL4^Akh.PW/Mmus\Prkaca^mC.UAS is a suppressor of decreased body size | pupal stage phenotype of Nf1^E2

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS/Scer\GAL4^Toll-6-D42 is a suppressor of abnormal neuroanatomy phenotype of Pka-C1^B3

(Yoshihara et al., 2005)

Mmus\Prkaca^mC.UAS/Scer\GAL4^Toll-6-D42 is a suppressor of abnormal neuroanatomy phenotype of Syt4^BA1

(Yoshihara et al., 2005)

NOT Suppressor of

Statement

Reference

Mmus\Prkaca^mC.UAS, Scer\GAL80^ts.αTub84B, Scer\GAL4^Oamb.4.4 is a non-suppressor of female semi-sterile | recessive phenotype of Oamb^unspecified

(Lee et al., 2009)

Mmus\Prkaca^mC.UAS/Scer\GAL4^{Itpr-1664GAL4} is a non-suppressor of abnormal developmental rate phenotype of Itpr^1664GAL4

(Venkatesh et al., 2001)

Other

Statement

Reference

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^Akh.PW has partially lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^Act5C.PU has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^elav.PU has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^Ras64B.PW has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^C23 has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^Feb36 has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^Aug21 has lethal phenotype

(Walker et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

Mmus\Prkaca^mC.UAS, Scer\GAL4^{VP16.nanos.UTR} has nurse cell phenotype, enhanceable by Akap200^k07118a/Df(2L)N22-14

(Jackson and Berg, 2002)

NOT Enhanced by

Statement

Reference

Mmus\Prkaca^mC.UAS, Scer\GAL4^elav-C155 has neuromuscular junction | third instar larval stage phenotype, non-enhanceable by cpx^SH1/cpx^SH1

(Cho et al., 2015)

Suppressed by

Statement

Reference

Mmus\Prkaca^mC.UAS, Scer\GAL4^tey-5053A has axon | third instar larval stage | conditional phenotype, suppressible by wnd^GD13786, Scer\GAL4^tey-5053A

(Hao et al., 2016)

Mmus\Prkaca^mC.UAS, Scer\GAL4^tey-5053A has motor neuron | third instar larval stage | conditional phenotype, suppressible by wnd^GD13786, Scer\GAL4^tey-5053A

(Hao et al., 2016)

Mmus\Prkaca^mC.UAS, Scer\GAL4^elav-C155, cpx^SH1 has neuromuscular junction | third instar larval stage phenotype, suppressible | partially by cpx^S126A.UAS.7B, Scer\GAL4^elav-C155

(Cho et al., 2015)

NOT suppressed by

Statement

Reference

Mmus\Prkaca^mC.UAS, Scer\GAL4^tey-5053A has axon | third instar larval stage | conditional phenotype, non-suppressible by moody^KK100674, Scer\GAL4^tey-5053A

(Hao et al., 2016)

Mmus\Prkaca^mC.UAS, Scer\GAL4^tey-5053A has motor neuron | third instar larval stage | conditional phenotype, non-suppressible by moody^KK100674, Scer\GAL4^tey-5053A

(Hao et al., 2016)

Mmus\Prkaca^mC.UAS, Scer\GAL4^elav-C155, cpx^SH1 has neuromuscular junction | third instar larval stage phenotype, non-suppressible by cpx^UAS.7B, Scer\GAL4^elav-C155

(Cho et al., 2015)

Mmus\Prkaca^mC.UAS, Scer\GAL4^elav-C155, cpx^SH1 has neuromuscular junction | third instar larval stage phenotype, non-suppressible by cpx^S126D.UAS.7B, Scer\GAL4^elav-C155

(Cho et al., 2015)

Enhancer of

Statement

Reference

Mmus\Prkaca^mC.UAS, Scer\GAL4^ppk.PG is an enhancer of larval multidendritic class IV neuron phenotype of Rab5^S43N.UAS, Scer\GAL4^ppk.PG

(Copf, 2014)

Mmus\Prkaca^mC.UAS, Scer\GAL4^ppk.PG is an enhancer of dendrite phenotype of Rab5^S43N.UAS, Scer\GAL4^ppk.PG

(Copf, 2014)

Mmus\Prkaca^mC.UAS, Scer\GAL4^ppk.PG is an enhancer of dendritic branch point phenotype of Rab5^S43N.UAS, Scer\GAL4^ppk.PG

(Copf, 2014)

Mmus\Prkaca^mC.UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Mmus\Prkaca^mC.UAS, Scer\GAL4^GMR.PF is an enhancer of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

Mmus\Prkaca^mC.UAS/Scer\GAL4^Toll-6-D42 is a suppressor of motor neuron phenotype of Pka-C1^B3

(Yoshihara et al., 2005)

Mmus\Prkaca^mC.UAS/Scer\GAL4^Toll-6-D42 is a suppressor of motor neuron phenotype of Syt4^BA1

(Yoshihara et al., 2005)

NOT Suppressor of

Statement

Reference

Mmus\Prkaca^mC.UAS, Scer\GAL80^ts.αTub84B, Scer\GAL4^Oamb.4.4 is a non-suppressor of oviduct phenotype of Oamb^unspecified

(Lee et al., 2009)

Mmus\Prkaca^mC.UAS, Scer\GAL80^ts.αTub84B, Scer\GAL4^Oamb.4.4 is a non-suppressor of uterus phenotype of Oamb^unspecified

(Lee et al., 2009)

Mmus\Prkaca^mC.UAS, Scer\GAL4^71B is a non-suppressor of wing disc phenotype of Scer\GAL4^71B, ci^{5m.UAS.Tag:HA}

(Price and Kalderon, 1999)

Other

Statement

Reference

Akap200^k07118a/Df(2L)N22-14, Mmus\Prkaca^mC.UAS, Scer\GAL4^{VP16.nanos.UTR} has nurse cell phenotype

(Jackson and Berg, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of wnd^GD13786, but not moody^KK100674, suppresses the enhanced growth response of motoneuron axons after nerve crush injury seen in larvae expressing Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^tey-5053A.

(Hao et al., 2016)

cpx^SH1 mutant larvae expressing Mmus\Prkaca^mC.UAS under the control of Scer\GAL4^elav-C155 exhibit synaptic overgrowth (increased number of boutons) at neuromuscular junctions, similar to Mmus\Prkaca^mC.UAS expression alone, and this is not significantly affected by co-expression of either cpx^UAS.7B or cpx^S126D.UAS.7B but is significantly suppressed by cpx^S126A.UAS.7B.

(Cho et al., 2015)

Co-expression of Rab5^{S43N.Scer\UAS} and Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^ppk.PG results in more severe loss of complexity in class IV dendritic arbors than when either transgene is expressed alone.

(Copf, 2014)

Expression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^Akh.PW suppresses the reduced pupal length phenotype seen in Nf1^E2 animals.

(Walker et al., 2013)

Expression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^Oamb.4.4, using Scer\GAL80^ts.αTub84B to limit expression to 3 days prior to mating, fails to suppress the ovulation phenotype seen in Oamb^unspecified homozygotes.

(Lee et al., 2009)

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced by co-expression of Mmus\Pkaca^mC.Scer\UAS; the size of the eye is reduced and necrotic foci are formed.

(Shulman and Feany, 2003)

30% of egg chambers have at least one binucleate nurse cell in Akap200^k07118a/Df(2L)N22-14 females expressing Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}.

(Jackson and Berg, 2002)

The wing disc phenotype caused by expression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^71B is still seen in animals also co-expressing either ci^{WT.P.Scer\UAS.T:Ivir\HA1} or ci^{3m.Scer\UAS.T:Ivir\HA1}. In contrast, in wing discs co-expressing ci^{5m.Scer\UAS.T:Ivir\HA1} and Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^71B, overgrowth of the wing blade region is seen, as in animals expressing ci^{5m.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^71B.

(Price and Kalderon, 1999)

When expressed with Pka-R1^BDK.Scer\UAS or Pka-R1^BGD.Scer\UAS under the influence of Scer\GAL4^E62-2, Scer\GAL4^h-1J3 or Scer\GAL4^C166-2, Mmus\Pkaca^mC.Scer\UAS completely suppresses adult pattern defects elicited by Pka-R1^BDK.Scer\UAS or Pka-R1^BGD.Scer\UAS. Adults have normal legs, blistered wings, no cuticular outgrowths or duplicated wings.

(Li et al., 1995)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Exists in clones, not reported as being germ-line transmitted.

(Li et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Mmus\Pkaca^mC.Scer\UAS

Mmus\Prkaca^mC.Scer\UAS

Mmus\Prkaca^mC.UAS

PKA^mC.UAS

Name Synonyms

Secondary FlyBase IDs

References (49)

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