FlyBase Gene Report: Dmel\cni

General Information

Symbol

Dmel\cni

Species

D. melanogaster

Name

cornichon

Annotation Symbol

CG5855

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000339

Gene Model Status

Stock Availability

10 publicly available

Gene Summary

Acts as cargo receptor necessary for the transportation of gurken (grk) to a transitional endoplasmic reticulum (tER) site and promotes its incorporation into coat protein complex II (COPII) vesicles. Associated with gurken, produces a signal received by torpedo resulting in a signaling pathway that first establishes posterior follicle cell fates and normal localization of the anterior and posterior determinants, later they act in a signaling event inducing dorsal follicle cell fates and regulating the dorsal-ventral pattern of egg and embryo. (UniProt, P49858)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

BG:DS02740.13

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:16,309,292..16,310,726 [-]

Recombination map

2-52

RefSeq locus

NT_033779 REGION:16309292..16310726

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:P42287

(assigned by UniProt )

(Bokel et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (6 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in anterior/posterior pattern specification

inferred from mutant phenotype

(Roth et al., 1995)

involved_in blastoderm segmentation

inferred from mutant phenotype

(Roth et al., 1995)

involved_in dorsal appendage formation

inferred from mutant phenotype

(Peri and Roth, 2000)

involved_in endoplasmic reticulum to Golgi vesicle-mediated transport

inferred from mutant phenotype

(Herpers and Rabouille, 2004)

inferred from mutant phenotype

(assigned by UniProt )

(Bokel et al., 2006)

involved_in oocyte dorsal/ventral axis specification

inferred from mutant phenotype

(Roth et al., 1995)

involved_in vesicle-mediated transport

inferred from mutant phenotype

(Bokel et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in endoplasmic reticulum to Golgi vesicle-mediated transport

inferred from biological aspect of ancestor with PANTHER:PTN000265246

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in endoplasmic reticulum membrane

inferred from direct assay

(assigned by UniProt )

(Bokel et al., 2006)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in COPII-coated ER to Golgi transport vesicle

inferred from biological aspect of ancestor with PANTHER:PTN000265246

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in endoplasmic reticulum membrane

inferred from biological aspect of ancestor with PANTHER:PTN000265246

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the cornichon family. (P49858)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

Acts as cargo receptor necessary for the transportation of gurken (grk) to a transitional endoplasmic reticulum (tER) site and promotes its incorporation into coat protein complex II (COPII) vesicles. Associated with gurken, produces a signal received by torpedo resulting in a signaling pathway that first establishes posterior follicle cell fates and normal localization of the anterior and posterior determinants, later they act in a signaling event inducing dorsal follicle cell fates and regulating the dorsal-ventral pattern of egg and embryo.

(UniProt, P49858)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

3

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\cni for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0080848

811

144

FBtr0080849

878

144

FBtr0337082

1132

144

Additional Transcript Data and Comments

Reported size (kB)

0.9 (northern blot)

(Roth et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0080405

16.9

144

6.77

FBpp0080406

16.9

144

6.77

FBpp0308005

16.9

144

6.77

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

144 aa isoforms: cni-PA, cni-PB, cni-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

144 (aa); 17 (kD predicted)

(Roth et al., 1995)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with grk.

(UniProt, P49858)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cni using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

cni_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage & oogenesis

(Roth et al., 1995)

adult stage & oogenesis stage S10

(Roth et al., 1995)

oogenesis stage S1 -- S7

(Roth et al., 1995)

Additional Descriptive Data

cni transcripts are expressed in the germarium, in early egg chambers, and in the nurse cells of a stage S10 egg chamber. cni expression is strongly down-regulated in egg chambers of stages S8 and S9.

(Roth et al., 1995)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endoplasmic reticulum membrane

inferred from direct assay

(assigned by UniProt )

(Bokel et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\cni in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\cni

View exonic expression by tissue for Dmel\cni

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB

34967/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0000339

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG5855-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5855

Flygut - An atlas of the Drosophila adult midgut

FBgn0000339

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of cni

Transgenic constructs containing regulatory region of cni

Aberrations (Deficiencies and Duplications) ( 61 )

Inferred from experimentation ( 61 )

Gene not disrupted in

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

Df(2L)cact-255rv64

(Dawson et al., 1995)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

Df(2L)k08106-rv4

(Roote, 2000.6.13)

Df(2L)k08106-rv6

(Roote, 2000.6.13)

Df(2L)k08106-rv15

(Roote, 2000.6.13)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Eberl et al., 1998)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

Df(2L)TE35BC-34

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Eberl et al., 1998, Dawson et al., 1995, Ashburner et al., 1990)

(Eberl et al., 1998, Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

(Ashburner et al., 1990)

In(2L)dpp^s22Ldpp^d36R

(Ashburner et al., 1990)

(Eberl et al., 1998, Dawson et al., 1995, Ashburner et al., 1990)

In(2LR)Sco^rv1-DV7

(Ashburner et al., 1990)

(Ashburner et al., 1990)

Gene duplicated in

(Ashburner et al., 1990)

Gene not duplicated in

Dp(2;1)Sco^rv23

(Ashburner et al., 1990)

(Ashburner et al., 1990)

Dp(2;2)TE35B-54^L

(Ashburner et al., 1990)

In(2L)C163.41^LC158^R

(Ashburner et al., 1990)

In(2L)Sco^rv17LC158^R

(Ashburner et al., 1990)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with cni¹), with Df(2L)JS7

cni^AA12

lethal (with cni^AA12), with Df(2L)JS7

cni¹

lethal | maternal effect

cni^unspecified

lethal - all die during embryonic stage | maternal effect | recessive

cni¹

partially lethal - majority die | abnormal dorsal/ventral axis specification

cni¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

cni^GD4518

viable, with Scer\GAL4^Mef2.PR

cni^GD4518

viable, with Scer\GAL4^pnr-MD237

cni^GD4518

viable, with Scer\GAL4^tin.CΔ4

cni^GD4518

Other Phenotypes

Allele

some die during embryonic stage | recessive | maternal effect | recessive

cni¹

Phenotype manifest in

Allele

dorsal appendage

dorsal appendage | ectopic

cni¹

dorsal appendage | maternal effect

cni¹

egg (with cni¹)

cni^AA12

egg (with cni^AA12)

cni¹

cni¹

embryonic epidermis

embryonic epidermis | maternal effect

cni¹

cni¹

interommatidial bristle | ectopic

cni¹

cni^AA12

mesoderm | maternal effect

cni¹

micropyle | ectopic

cni¹

ocellar bristle

cni¹

cni¹

oocyte (with cni¹)

cni^CF5

oocyte (with cni^CF5)

cni¹

cni¹

oocyte nucleus (with cni¹)

cni^AA12

oocyte nucleus (with cni^AA12)

cni¹

postvertical bristle

cni¹

cni¹

cni¹

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

11 of 15

No

Yes

1

11 of 15

No

Yes

1

5 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

10 of 15

No

Yes

10 of 15

No

Yes

4 of 15

No

No

Rattus norvegicus (Norway rat) (4)

11 of 13

Yes

Yes

11 of 13

Yes

Yes

11 of 13

Yes

Yes

4 of 13

No

No

Xenopus tropicalis (Western clawed frog) (4)

10 of 12

Yes

Yes

10 of 12

Yes

Yes

4 of 12

No

No

2 of 12

No

Yes

Danio rerio (Zebrafish) (4)

10 of 15

Yes

Yes

10 of 15

Yes

Yes

9 of 15

No

Yes

3 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (2)

13 of 15

Yes

Yes

1 of 15

No

Yes

Arabidopsis thaliana (thale-cress) (5)

7 of 9

Yes

Yes

5 of 9

No

Yes

5 of 9

No

Yes

5 of 9

No

Yes

5 of 9

No

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

10 of 15

Yes

No

9 of 15

No

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

9 of 12

Yes

Yes

Spom\SPAC2C4.05

8 of 12

No

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190I52 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00001757

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150DN7 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07603

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL007332

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL007327

Anopheles darlingi

American malaria mosquito

Adar\ADAC000961

Anopheles gambiae

Malaria mosquito

Agam\AGAP008974

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009353

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0IFQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Danaus plexippus

Monarch butterfly

Dple\DPOGS207650-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL009304

Apis florea

Little honeybee

Aflo\2148364307

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG010635

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM348080

Rhodnius prolixus

Kissing bug

Rpro\RPRC014581

Cimex lectularius

Bed bug

Clec\CLEC011448

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005267

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000183

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI080603

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_04599

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0JP9 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR005687

Ixodes scapularis

Black-legged tick

Isca\ISCW007754

Stegodyphus mimosarum

African social velvet spider

Smim\KFM81922.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g06580

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_189492

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0KIX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000019572

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

7 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CNIH1; cornichon family AMPA receptor auxiliary protein 1

14 of 15

CNIH2; cornichon family AMPA receptor auxiliary protein 2

11 of 15

CNIH3; cornichon family AMPA receptor auxiliary protein 3

11 of 15

CNIH4; cornichon family AMPA receptor auxiliary protein 4

5 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

anti bait coimmunoprecipitation, anti tag western blot

(Castro et al., 2007)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Bokel et al., 2006)

suppressible

(Bokel et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Interacts with grk.

(UniProt, P49858 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0000339

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34967

MIST (genetic) - An integrated Molecular Interaction Database

cni

MIST (protein-protein) - An integrated Molecular Interaction Database

cni

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-52

Cytogenetic map

Sequence location

2L:16,309,292..16,310,726 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

35F1-35F1

Limits computationally determined from genome sequence between P{lacW}heix^k11403&P{lacW}heix^k12401 and P{EP}fzy^EP1028&P{lacW}mRpL4^k14608

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

35F6-35F12

(Dawson et al., 1995)

Experimentally Determined Recombination Data

Location

2-52

(FlyBase, 2016)

2-49.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

13056

y¹ w^67c23; P{SUPor-P}cni^KG00189

1579

b¹ cni¹ pr¹ cn¹ bw¹/CyO

79315

y¹ w^*; TI{CRIMIC.TG4.2}cni^{CR00846-TG4.2}/SM6a

38919

y¹ sc^* v¹ sev²¹; P{TRiP.GL00691}attP2

34042

b¹ cni^AA112 pr¹ cn¹ wx^wxt bw¹/CyO

F001396

M{UAS-cni.ORF}ZH-86Fb

F000844

M{UAS-cni.ORF.3xHA}ZH-86Fb

106398

b¹ cni¹ pr¹ cn¹ bw¹/CyO

v102019

P{KK109331}VIE-260B

v37723

w¹¹¹⁸; P{GD4518}v37723

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (58)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE07818

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000339

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000339

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34967

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: cni CG5855

(Zhong, 1999.11)

Source for database merge of

Source for merge of: cni anon-35Fe

(Roth et al., 1995)

Additional comments

Other Comments

Transcript identified during molecular analysis of the fzy genomic region.

(Dawson et al., 1995)

cni is required for the induction of both posterior and dorsal follicle cell fates. cni is probably required in the oocyte for the production of the inducing signal, but as mutations do not affect grk localisation to the posterior of the oocyte cni must act at a different step in the pathway.

(Gonzalez-Reyes et al., 1995)

Comparison of protein sequence demonstrates that six conservative amino acid changes distinguish cni from Dvir\cni.

(Roth et al., 1995)

cni is required for Egfr signalling in oogenesis. This signalling pathway is required for dorsal ventral patterning and for the correct anterior posterior polarisation of the oocyte in midoogenesis.

(Roth et al., 1995)

Displays epistatic interactions with sqd alleles.

(Kelley, 1993)

2 alleles are discussed but are not named.

(Ashburner et al., 1990)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34967

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P49858

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9PDJ6

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000339

DRscDB

34967/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0000339

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

cni_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5855

Flygut - An atlas of the Drosophila adult midgut

FBgn0000339

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34967

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013453

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG5855

MARRVEL_MODEL

34967

modMine - A data warehouse for the modENCODE project

FBgn0000339

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0000339

DRSC - Results frm RNAi screens

FBgn0000339

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG5855-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000339

FlyMine - An integrated database for Drosophila genomics

FBgn0000339

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34967

MIST (genetic) - An integrated Molecular Interaction Database

cni

MIST (protein-protein) - An integrated Molecular Interaction Database

cni

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

BG:DS02740.13

(Ashburner et al., 1999, Ashburner et al., 1999.10.12)

CG5855

(Schertel et al., 2013, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)

Cni

(Castro et al., 2007, Bokel et al., 2006)

IV

(Dawson et al., 1995)

anon-35Fe

cni

(Kiragasi et al., 2020, Hall et al., 2019, Gene Disruption Project members, 2018-, Van Bortle et al., 2015, Kwon et al., 2013, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Dworkin et al., 2009, Kugler et al., 2009, Pizette et al., 2009, Snee and Macdonald, 2009)

spnG

Name Synonyms

Cornichon

(Castro et al., 2007, Bokel et al., 2006)

cornichon

(Kiragasi et al., 2020, Schüpbach, 2019, Cammarato et al., 2011, Snee and Macdonald, 2009)

spindle-G

Secondary FlyBase IDs

FBgn0020601

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (96)

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