Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
There is only one protein coding transcript and one polypeptide associated with this gene
679 (aa); 85 (kD observed); 77 (kD predicted)
Homodimer. Interacts with microtubules via its N-terminus.
The coiled coil domain mediates homodimerization.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hook using the Feature Mapper tool.
The multivesicular bodies in which hk protein is detected are a component of the general endocytic compartment. In embryos, cortical areas of cells stain for hk protein in a punctate pattern. In the oocyte, a similar cortical localization is detected, while in the nurse cell, staining is even throughout the cytoplasm.
GBrowse - Visual display of RNA-Seq signalsView Dmel\hook in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
hk is required for the normal endocytic trafficking of different classes of ligands.
hk is required late in endocytic trafficking to negatively regulate delivery from mature multivesicular bodies to multilammelar late endosomes and lysosomes.
Mutants do not exhibit defects in the denticle belt of hairs of the larvae.
Mutations in hk inhibit the accumulation of boss protein in multivesicular bodies in R7 cells. hk is molecularly characterised and results indicate the hk protein is a novel component of the endocytic compartment.
Located between coordinates -85.2 and -82.5.