- Tools
- Downloads
- Links
- Community
- About
- Help
FB2026_01
,
released March 12, 2026
Alp23B, Activin Like Protein at 23B, Alp
TGF-ß superfamily ligand - Activin-like protein - by activating Dawdle, Tolloid-related provides a permissive signal for axon guidance - Dawdle signals preferentially through one isoform of the Type-I receptor Baboon - Activin-β and Dawdle function redundantly to regulate proliferation in the larval brain
Please see the JBrowse view of Dmel\daw for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Proteolytically cleaved by tok and tld to produce a 20 kDa product; cleavage strongly enhances signaling properties.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\daw using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
daw transcript is expressed in the developing larval optic lobe, and in many glial cells, including surface glia within the optic lobe.
Maternally deposited daw transcript can be detected in embryos through syncytial blastoderm stage. daw transcript is expressed in the dorsal mesoderm, in a pattern that refines to segmental stripes during germ band extension and retraction stages. In third instar larvae, daw is strongly expressed in the central nervous system, and transiently in the ring gland. daw transcript is weakly expressed in eye-antennal and leg discs, and is not significantly expressed in wing discs. In the adult testis, daw transcipt is strongly expressed in somatic cells in the region where secondary spermatogonia are mitotically active. No expression is observed in the stem cells at the tip of the testis, or in primary spermatocytes; weak expression is observed during spermatid differentiation. daw transcript is expressed in nurse cells at all stages of oogenesis.
JBrowse - Visual display of RNA-Seq signals
View Dmel\daw in JBrowse
2-7
2-6.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Alp23B CG16987
Source for identity of: daw Alp23B
This gene has been renamed from "Activin Like Protein at 23B" (Alp23B) to "dawdle" (daw) to avoid confusion with "Abnormal leg pattern" (Alp) and to better reflect the mutant phenotype.
The name "dawdle" refers to the delayed nature of the innervation defects seen in mutants of this gene.
