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FB2026_02
,
released June 18, 2026
flavoprotein monooxygenase - large, multidomain protein expressed in axons - interacts with the neuronal Plexin A - enzymatic function required for Semaphorin 1a/PlexA-mediated repulsive axon guidance
Please see the JBrowse view of Dmel\Mical for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Shares 5' UTR with nested gene (one isoform in each case).
Gene model reviewed during 5.49
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.42
Gene model reviewed during 6.02
Interacts with plexA.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mical using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Mical protein is not homogenously distributed
in developing muscles but accumulates preferentially at the plasma membrane and at muscle attachment sites. It can be seen to outline the muscles and emphasizing the cleft between neighboring muscle fibers.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Mical in JBrowse
3-49
3-46.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Mical has a cell-autonomous role in dendrite pruning and is specifically required for dendrite severing of class I and IV dendritic arborization neurons, but is dispensable for neuronal apoptosis in other apoptotic dendritic arborization neurons during early metamorphosis.
Mical is required for the organisation of myofilaments into sarcomeres.
Source for merge of: Mical CG11685 CG11687 CG18668 CG18667
Source for identity of MICAL CG11685 CG11687 CG18668 CG18667 was sequence comparison ( date:020710 ).
Gene is named "milchstrasse" (German for "milky way") based on the resemblance of bouton accumulations (marked with a fluorescent protein) to star clusters or galaxies at the neuromuscular junctions of mutant larvae.
