FlyBase Allele Report: Dmel\Pc[1]

Pc¹/+ adults exhibit sex combs on the second and third pairs of legs of male flies, and a defective wing development indicative of a wing to haltere transformation.

(Fresán et al., 2020)

Pc¹ heterozygous males show a highly prevalent ectopic sex comb phenotype.

(Umer et al., 2019)

A significant proportion of Pc¹ heterozygous adults show a super sex comb phenotype, as compared to controls.

(Mariappa et al., 2018)

Pc¹/+ males display a homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs.

(Morimoto et al., 2016)

33% of heterozygous males have homeotic transformations of the second and third legs into the first leg (score by the presence of a sex comb on the second and/or third leg).

(Rincon-Arano et al., 2012)

64% of heterozygous males show transformation of T3 or T2 legs into T1 identity.

(Lamiable et al., 2010)

Males heterozygous for Pc¹ exhibit posterior-to-anterior leg transformation, readily visualized by the ectopic appearance of sex combs on the second or both the second and third legs.

(Chalkley et al., 2008)

One copy of Pc¹ is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)w^m4.

One copy of Pc¹ is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

(Doheny et al., 2008)

Heterozygous adults display the following homeotic transformations: sex combs on the second and/or third leg, transformation of the fourth abdominal segment into the semblance of the posterior fifth and defective wing development indicative of wing-to-haltere transformation.

(Lagarou et al., 2008)

Heterozygous larvae show no significant defects in dendrite morphology of class IV dendrite arborisation (da) neurons.

Heterozygous males have ectopic sex combs on the second and third legs.

(Parrish et al., 2007)

Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w^+mW.hs allele at the telomeres of the second and third chromosomes.

(Cryderman et al., 1999)

Heterozygous adults show transformations of 2nd leg to 1st leg, wing to haltere, and ventral wing margin to dorsal wing margin.

(Tiong and Russell, 1990)

Transformation of anterior segments to the 8th abdominal segment. Double heterozygous adult escapers show a mild homeotic transformation.

(Capdevila et al., 1986)

Homozygous embryos show variable transformation of the mesothoracic denticle belt and anterior-most dorsal spinules to resemble those of more posterior segments. There is also an anterior transformation of some mesothoracic cuticle structures, such as a reduction in spinule density on the dorsal surface.

(Sato and Denell, 1985)

partial transformations of second and third legs into first legs in Pc/+ heterozygotes

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Pc¹ has visible | adult stage | dominant | male limited phenotype, enhanceable by Zrf1¹⁴⁸

(Shun Li et al., 2025)

Pc¹ has visible | adult stage | dominant | male limited phenotype, enhanceable by Zrf1²⁴²

(Shun Li et al., 2025)

Pc¹ has visible | male phenotype, enhanceable by CCT5⁰⁶⁴⁴⁴

(Shaheen et al., 2021)

Pc¹ has visible | male phenotype, enhanceable by CCT7^KG01477

(Shaheen et al., 2021)

Pc¹ has visible | male phenotype, enhanceable by CCT7^KG09501

(Shaheen et al., 2021)

Pc¹ has visible | male phenotype, enhanceable by CCT5^k06005

(Shaheen et al., 2021)

Pc¹ has homeotic phenotype, enhanceable by Haspin¹²⁸/Haspin¹²⁸

(Fresán et al., 2020)

Pc¹ has homeotic | dominant | male phenotype, enhanceable by CG9007[+]/upSET^e00365

(Rincon-Arano et al., 2012)

Pc¹ has homeotic | dominant | male phenotype, enhanceable by upSET^MB08950/CG9007[+]

(Rincon-Arano et al., 2012)

Pc¹ has visible phenotype, enhanceable by Hcf[+]/Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc¹ has visible | dominant phenotype, enhanceable by Rm62[+]/Rm62⁰¹⁰⁸⁶

(Lamiable et al., 2010)

Pc¹ has homeotic phenotype, enhanceable by Kdm2^KG04325/Kdm2[+]

(Lagarou et al., 2008)

Pc¹ has homeotic phenotype, enhanceable by Kdm2^EY01336/Kdm2[+]

(Lagarou et al., 2008)

Pc¹ has homeotic phenotype, enhanceable by Kdm2[+]/Kdm2^DG12810

(Lagarou et al., 2008)

Pc¹ has visible | dominant phenotype, enhanceable by wts^x1/wts[+]

(Parrish et al., 2007)

Pc¹ has visible | homeotic phenotype, enhanceable by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc¹ has visible | homeotic | female phenotype, enhanceable by Usp7^KG06814/Usp7[+]

(van der Knaap et al., 2005)

Pc¹ has visible | homeotic phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc¹ has visible | homeotic | female phenotype, enhanceable by Usp7^kim1/Usp7[+]

(van der Knaap et al., 2005)

Pc¹ has visible | homeotic | male phenotype, enhanceable by Usp7^kim1

(van der Knaap et al., 2005)

Suppressed by

Statement

Reference

Pc¹ has homeotic | dominant | male | adult stage phenotype, suppressible | partially by CtBP[+]/CtBP⁰³⁴⁶³

(Bi et al., 2022)

Pc¹ has homeotic | dominant | male | adult stage phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

Pc¹ has visible | dominant | male | adult stage phenotype, suppressible | partially by CtBP[+]/CtBP⁰³⁴⁶³

(Bi et al., 2022)

Pc¹ has visible | dominant | male | adult stage phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

Pc¹ has homeotic | adult stage phenotype, suppressible by enok¹/enok[+]

(Umer et al., 2019)

Pc¹ has homeotic | adult stage phenotype, suppressible by enok[+]/enok²

(Umer et al., 2019)

Pc¹ has homeotic phenotype, suppressible by Marcal1[+]/Marcal1^del

(Morimoto et al., 2016)

Pc¹ has homeotic phenotype, suppressible by Marcal1^del/Marcal1^del

(Morimoto et al., 2016)

Pc¹, ph-p[+]/ph-p⁴¹⁰ has homeotic phenotype, suppressible | partially by Marcal1^del/Marcal1^del

(Morimoto et al., 2016)

Enhancer of

Statement

Reference

Pc¹/Pc[+] is an enhancer of visible | adult stage phenotype of eya^cs/eya¹

(Tian et al., 2019)

Pc¹/Pc[+] is an enhancer of visible | adult stage phenotype of eya^cs/eya²

(Tian et al., 2019)

Pc¹/Pc[+] is an enhancer of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Pc¹/Pc[+] is an enhancer of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Pc¹/Pc[+] is an enhancer of visible | dominant phenotype of gcm^Pyx

(Popkova et al., 2012)

NOT Enhancer of

Statement

Reference

Pc¹/Pc[+] is a non-enhancer of decreased body size | adult stage phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc¹ is a non-enhancer of visible phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Suppressor of

Statement

Reference

Pc¹ is a suppressor of increased cell number phenotype of trx^E2

(Tauc et al., 2021)

NOT Suppressor of

Statement

Reference

Pc¹/Pc[+] is a non-suppressor of decreased body size | adult stage phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc¹ is a non-suppressor of visible phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Other

Statement

Reference

Pc¹, ph-p[+]/ph-p⁴¹⁰ has homeotic phenotype

(Morimoto et al., 2016)

Ino80[+]/Ino80^Δ4, Pc¹ has visible | dominant phenotype

(Bhatia et al., 2010)

Pc¹/Pc[+], Su(z)12⁴ has abnormal neuroanatomy | dominant phenotype

(Parrish et al., 2007)

Asx^XF23, Pc¹, P{hsp26-pt-T}39C-5 has suppressor of variegation phenotype

(Boivin et al., 2003)

E(z)⁵, Pc¹, P{hsp26-pt-T}39C-5 has suppressor of variegation phenotype

(Boivin et al., 2003)

Pc¹, P{hsp26-pt-T}39C-5, ph-p⁴¹⁰ has suppressor of variegation phenotype

(Boivin et al., 2003)

Antp⁴⁹, Pc¹ has lethal | dominant phenotype

(Lindsley and Grell, 1968)

E(Pc)a¹, Pc¹ has visible | homeotic phenotype

Phenotype Manifest In

Enhanced by

Statement

Reference

Pc¹ has sex comb | increased number phenotype, enhanceable by Zrf1¹⁴⁸

(Shun Li et al., 2025)

Pc¹ has sex comb | increased number phenotype, enhanceable by Zrf1²⁴²

(Shun Li et al., 2025)

Pc¹ has sex comb phenotype, enhanceable by CCT5⁰⁶⁴⁴⁴

(Shaheen et al., 2021)

Pc¹ has sex comb phenotype, enhanceable by CCT7^KG01477

(Shaheen et al., 2021)

Pc¹ has sex comb phenotype, enhanceable by CCT7^KG09501

(Shaheen et al., 2021)

Pc¹ has sex comb phenotype, enhanceable by CCT5^k06005

(Shaheen et al., 2021)

Pc¹ has sex comb | ectopic phenotype, enhanceable by sxc[+]/sxc^H537A

(Mariappa et al., 2018)

Pc¹ has sex comb | ectopic phenotype, enhanceable by sxc^H537A

(Mariappa et al., 2018)

Pc¹ has sex comb | ectopic phenotype, enhanceable by pds5^e3

(Schaaf et al., 2013)

Pc¹ has sex comb | ectopic | male phenotype, enhanceable by CG9007[+]/upSET^e00365

(Rincon-Arano et al., 2012)

Pc¹ has sex comb | ectopic | male phenotype, enhanceable by upSET^MB08950/CG9007[+]

(Rincon-Arano et al., 2012)

Pc¹ has mesothoracic preepisternum phenotype, enhanceable by Hcf[+]/Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc¹ has mesothoracic leg phenotype, enhanceable by Rm62[+]/Rm62⁰¹⁰⁸⁶

(Lamiable et al., 2010)

Pc¹ has metathoracic leg phenotype, enhanceable by Rm62[+]/Rm62⁰¹⁰⁸⁶

(Lamiable et al., 2010)

Pc¹ has sex comb | ectopic phenotype, enhanceable by Rm62[+]/Rm62⁰¹⁰⁸⁶

(Lamiable et al., 2010)

Pc¹ has sex comb | ectopic phenotype, enhanceable by wts^x1/wts[+]

(Parrish et al., 2007)

Pc¹ has mesothoracic leg phenotype, enhanceable by wts^x1/wts[+]

(Parrish et al., 2007)

Pc¹ has metathoracic leg phenotype, enhanceable by wts^x1/wts[+]

(Parrish et al., 2007)

Pc¹ has prothoracic leg | ectopic | male phenotype, enhanceable by Usp7^kim1

(van der Knaap et al., 2005)

Pc¹ has sex comb | ectopic | male phenotype, enhanceable by Usp7^kim1

(van der Knaap et al., 2005)

Pc¹ has wing | male phenotype, enhanceable by Usp7^kim1

(van der Knaap et al., 2005)

Pc¹ has abdominal segment 4 | male phenotype, enhanceable by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc¹ has abdominal segment 5 | ectopic | male phenotype, enhanceable by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc¹ has haltere | ectopic phenotype, enhanceable by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc¹ has prothoracic leg | ectopic | male phenotype, enhanceable by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc¹ has sex comb | ectopic | male phenotype, enhanceable by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc¹ has wing phenotype, enhanceable by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc¹ has abdominal segment 4 | male phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc¹ has abdominal segment 5 | ectopic | male phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc¹ has haltere | ectopic phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc¹ has prothoracic leg | ectopic | male phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc¹ has sex comb | ectopic | male phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc¹ has wing phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc¹ has haltere | ectopic | female phenotype, enhanceable by Usp7^kim1/Usp7[+]

(van der Knaap et al., 2005)

Pc¹ has wing | female phenotype, enhanceable by Usp7^kim1/Usp7[+]

(van der Knaap et al., 2005)

Pc¹ has haltere | ectopic | female phenotype, enhanceable by Usp7^KG06814/Usp7[+]

(van der Knaap et al., 2005)

Pc¹ has wing | female phenotype, enhanceable by Usp7^KG06814/Usp7[+]

(van der Knaap et al., 2005)

Pc¹ has abdominal segment 4 | male phenotype, enhanceable by Usp7^kim1

(van der Knaap et al., 2005)

Pc¹ has abdominal segment 5 | ectopic | male phenotype, enhanceable by Usp7^kim1

(van der Knaap et al., 2005)

Pc¹ has haltere | ectopic | male phenotype, enhanceable by Usp7^kim1

(van der Knaap et al., 2005)

Pc¹ has mesothoracic leg | male phenotype, enhanceable by Usp7^kim1

(van der Knaap et al., 2005)

NOT Enhanced by

Statement

Reference

Pc¹ has sex comb | ectopic phenotype, non-enhanceable by pds5^e6

(Schaaf et al., 2013)

Suppressed by

Statement

Reference

Pc¹ has metathoracic leg | male phenotype, suppressible by CtBP[+]/CtBP⁰³⁴⁶³

(Bi et al., 2022)

Pc¹ has prothoracic leg | ectopic | male phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

Pc¹ has prothoracic leg | ectopic | male phenotype, suppressible | partially by CtBP[+]/CtBP⁰³⁴⁶³

(Bi et al., 2022)

Pc¹ has mesothoracic leg | male phenotype, suppressible | partially by CtBP[+]/CtBP⁰³⁴⁶³

(Bi et al., 2022)

Pc¹ has metathoracic leg | male phenotype, suppressible by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

Pc¹ has mesothoracic leg | male phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

Pc¹ has wing phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

Pc¹ has sex comb | ectopic phenotype, suppressible by enok¹/enok[+]

(Umer et al., 2019)

Pc¹ has sex comb | ectopic phenotype, suppressible by enok[+]/enok²

(Umer et al., 2019)

Pc¹ has sex comb phenotype, suppressible by Marcal1[+]/Marcal1^del

(Morimoto et al., 2016)

Pc¹ has sex comb phenotype, suppressible by Marcal1^del/Marcal1^del

(Morimoto et al., 2016)

Pc¹, ph-p[+]/ph-p⁴¹⁰ has wing phenotype, suppressible | partially by Marcal1^del/Marcal1^del

(Morimoto et al., 2016)

Pc¹ has sex comb | ectopic phenotype, suppressible by vtd⁶

(Schaaf et al., 2013)

Pc¹ has sex comb | ectopic phenotype, suppressible by vtd^80Fh-36

(Schaaf et al., 2013)

Pc¹ has sex comb | ectopic phenotype, suppressible by SMC1^exc46

(Schaaf et al., 2013)

Pc¹ has sex comb | ectopic phenotype, suppressible by Nipped-B⁴⁰⁷

(Schaaf et al., 2013)

Pc¹ has sex comb phenotype, suppressible by rdx¹

(Strübbe et al., 2011)

Pc¹ has sex comb phenotype, suppressible by rdx²

(Strübbe et al., 2011)

Pc¹ has sex comb phenotype, suppressible by rdx⁵

(Strübbe et al., 2011)

Pc¹ has sex comb phenotype, suppressible by rdx⁶

(Strübbe et al., 2011)

Pc¹ has sex comb phenotype, suppressible by ebi^WKS-24

(Strübbe et al., 2011)

Pc¹ has sex comb phenotype, suppressible by ebi^CCS-6

(Strübbe et al., 2011)

Pc¹ has sex comb phenotype, suppressible by ebi^E90

(Strübbe et al., 2011)

Pc¹ has sex comb phenotype, suppressible by ebi^E4

(Strübbe et al., 2011)

Pc¹ has metathoracic leg phenotype, suppressible by rdx¹

(Strübbe et al., 2011)

Pc¹ has mesothoracic leg phenotype, suppressible by rdx¹

(Strübbe et al., 2011)

Pc¹ has metathoracic leg phenotype, suppressible by rdx²

(Strübbe et al., 2011)

Pc¹ has mesothoracic leg phenotype, suppressible by rdx²

(Strübbe et al., 2011)

Pc¹ has metathoracic leg phenotype, suppressible by rdx⁵

(Strübbe et al., 2011)

Pc¹ has mesothoracic leg phenotype, suppressible by rdx⁵

(Strübbe et al., 2011)

Pc¹ has metathoracic leg phenotype, suppressible by rdx⁶

(Strübbe et al., 2011)

Pc¹ has mesothoracic leg phenotype, suppressible by rdx⁶

(Strübbe et al., 2011)

Pc¹ has metathoracic leg phenotype, suppressible by ebi^CCS-6

(Strübbe et al., 2011)

Pc¹ has mesothoracic leg phenotype, suppressible by ebi^CCS-6

(Strübbe et al., 2011)

Pc¹ has metathoracic leg phenotype, suppressible by ebi^WKS-24

(Strübbe et al., 2011)

Pc¹ has mesothoracic leg phenotype, suppressible by ebi^WKS-24

(Strübbe et al., 2011)

Pc¹ has metathoracic leg phenotype, suppressible by ebi^E90

(Strübbe et al., 2011)

Pc¹ has mesothoracic leg phenotype, suppressible by ebi^E90

(Strübbe et al., 2011)

Pc¹ has metathoracic leg phenotype, suppressible by ebi^E4

(Strübbe et al., 2011)

Pc¹ has mesothoracic leg phenotype, suppressible by ebi^E4

(Strübbe et al., 2011)

Pc¹ has sex comb | ectopic phenotype, suppressible by polybromo^33.2/Bap170[+]/Bap170^G5986/polybromo[+]

(Chalkley et al., 2008)

Pc¹ has sex comb | ectopic phenotype, suppressible by e(y)3⁴/Bap170[+]/Bap170^G5986

(Chalkley et al., 2008)

Pc¹ has mesothoracic leg phenotype, suppressible by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc¹ has mesothoracic leg phenotype, suppressible by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Enhancer of

Statement

Reference

Pc¹/Pc[+] is an enhancer of eye phenotype of eya^cs/eya¹

(Tian et al., 2019)

Pc¹/Pc[+] is an enhancer of eye phenotype of eya^cs/eya²

(Tian et al., 2019)

Pc¹/Pc[+] is an enhancer of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Pc¹/Pc[+] is an enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Pc¹/Pc[+] is an enhancer of chaeta | increased number phenotype of gcm^Pyx

(Popkova et al., 2012)

NOT Enhancer of

Statement

Reference

Pc¹/Pc[+] is a non-enhancer of humeral bristle phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc¹/Pc[+] is a non-enhancer of sex comb phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc¹ is a non-enhancer of eye phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Suppressor of

Statement

Reference

Pc¹ is a suppressor of enteroendocrine cell | increased number phenotype of trx^E2

(Tauc et al., 2021)

Pc¹/Pc[+] is a suppressor of wing vein | ectopic phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc¹/Pc[+] is a suppressor of eye | somatic clone phenotype of Utx¹

(Herz et al., 2010)

Pc¹ is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

Pc¹/Pc[+] is a suppressor of adult abdominal segment 4 | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

Pc¹/Pc[+] is a suppressor of adult abdominal segment 5 phenotype of E(z)^Trm

(Bajusz et al., 2001)

Pc¹/Pc[+] is a suppressor of adult mesothoracic segment | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

Pc¹/Pc[+] is a suppressor of adult metathoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

Pc¹/Pc[+] is a suppressor of adult prothoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

NOT Suppressor of

Statement

Reference

Pc¹/Pc[+] is a non-suppressor of humeral bristle phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc¹/Pc[+] is a non-suppressor of sex comb phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc¹ is a non-suppressor of eye phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Pc¹ is a non-suppressor of wing phenotype of Scer\GAL4^OK386, nej^UAS.cMa

(Bantignies et al., 2000)

Other

Statement

Reference

Pc¹, ph-p[+]/ph-p⁴¹⁰ has wing phenotype

(Morimoto et al., 2016)

Hcf^HR1, Pc¹/Pc[+] has male genitalia phenotype

(Rodriguez-Jato et al., 2011)

Ino80[+]/Ino80^Δ4, Pc¹ has sex comb | ectopic phenotype

(Bhatia et al., 2010)

Ino80[+]/Ino80^Δ4, Pc¹ has mesothoracic leg phenotype

(Bhatia et al., 2010)

Ino80[+]/Ino80^Δ4, Pc¹ has metathoracic leg phenotype

(Bhatia et al., 2010)

Pc¹, Snr1^E1 has wing vein L2 phenotype

(Marenda et al., 2004)

Pc¹, Snr1^E1 has wing vein L5 phenotype

(Marenda et al., 2004)

Pc¹, Snr1^E1 has wing vein L4 phenotype

(Marenda et al., 2004)

Pc¹, Snr1^E1 has wing phenotype

(Marenda et al., 2004)

Pc¹, lolal^k02512 has wing phenotype

(Mishra et al., 2003)

Pc¹, lolal^k02512 has wing margin phenotype

(Mishra et al., 2003)

E(Pc)a¹, Pc¹ has mesothoracic leg phenotype

E(Pc)a¹, Pc¹ has metathoracic leg phenotype

E(Pc)a¹, Pc¹ has embryonic abdominal segment 1 phenotype

E(Pc)a¹, Pc¹ has embryonic abdominal segment 4 phenotype

Additional Comments

Genetic Interactions

Statement

Reference

The super sex comb phenotype observed in Pc¹ heterozygotes is enhanced by sxc^H537A heterozygosity, which is further enhanced by sxc^H537A homozygosity.

sxc^H537A/+, Pc¹/+ individuals and sxc^H537A/sxc^H537A, Pc¹/+ individuals do not show an ectopic scutellar bristle phenotype, as compared to controls.

(Mariappa et al., 2018)

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is exacerbated by combination with a single copy of Pc¹.

The homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs characteristic for Pc¹/+ males is partially suppressed by Marcal1^del heterozygosity and to a greater extent (yet still not a full rescue) by Marcal1^del homozygosity.

Similarly, the partial homeotic wing-to-haltere transformation observed in ph-p⁴¹⁰/+;Pc¹/+ double heterozygotes is ameliorated by combination with Marcal1^del in homozygosity.

(Morimoto et al., 2016)

The penetrance of the ectopic sex comb phenotype seen on the second and/or third legs of Pc¹/+ flies (33%) is enhanced if they are also heterozygous for either upSET^e00365 (75%) or upSET^MB08950 (75%).

(Rincon-Arano et al., 2012)

Hcf^HR1/+ enhances the penetrance of the T2 to T1 transformation (reduction of the sternopleural region) seen in Pc¹/+ flies, from 3% to 60%.

The adult size and humeral bristle phenotypes of Hcf^HR1 mutants are not affected by Pc¹/+. The reduced sex comb phenotype of Hcf^HR1 is not modified by Pc¹/+. The ectopic vein phenotype of Hcf^HR1 mutants is suppressed by Pc¹/+.

3% of Pc¹/+ ; Hcf^HR1 males have defects in rotation of the genitalia.

(Rodriguez-Jato et al., 2011)

Pc¹ Ino80^Δ4 double heterozygotes have ectopic sex combs on the second and third legs (complete penetrance).

(Bhatia et al., 2010)

Heterozygosity for Pc¹ suppresses the over-representation phenotype of Utx¹ mosaics.

(Herz et al., 2010)

95% of Pc¹/Rm62⁰¹⁰⁸⁶ double heterozygous males show transformation of T3 or T2 legs into T1 identity.

(Lamiable et al., 2010)

The frequency of posterior-to-anterior leg transformations is reduced in transheterozygous males when Pc¹ is combined with both Bap170^G5986/+ and polybromo^33.2/+. Hemizygous e(y)3⁴ males display an almost complete suppression of the Pc¹ leg transformation phenotype.

(Chalkley et al., 2008)

The frequency of homeotic transformations is significantly higher in flies transheterozygous for Pc¹ and Kdm2^KG04325, Kdm2^EY01336 or Kdm2^DG12810, compared to flies heterozygous for Pc¹ alone.

(Lagarou et al., 2008)

Pc¹/Su(z)12⁴ and Pc¹/E(z)⁶³ double heterozygous larvae show dendritic defects in class IV dendrite arborisation (da) neurons; there is a significant reduction in the number of dendritic branchpoints.

The ectopic sex comb phenotype seen on the second and third legs of Pc¹/+ males is enhanced by wts^x1/+.

(Parrish et al., 2007)

Usp7^KG06814 strongly enhances the frequency and severity of a range of homeotic transformations caused by Pc¹flies. In combination with either hetero- (females) or hemizygous (males) Pc¹ flies, Usp7^KG06814 significantly increases the penetrance of wing-to-haltere transformations. Likewise, there is a strong increase in the frequency and extent of transformations of the fourth abdominal segment (A4) into the semblance of the fifth (A5), indicated by increased dark pigmentation of the A4. Usp7^kim1 strongly enhances the frequency and severity of a range of homeotic transformations caused by Pc¹ flies. For example, wing-to-haltere transformations occur only very rarely in heterozygous Pc¹ flies. However, in combination with either hetero- or hemizygous Usp7^kim1, in respectively females or males, the penetrance of wing-to-haltere transformations is significantly increased. Likewise, there is a strong increase in the frequency and extent of transformations of the fourth abdominal segment (A4) into the semblance of the fifth (A5), indicated by increased dark pigmentation of the A4. In males hemizygous for Usp7^kim1 and heterozygous for Pc¹, the frequency of sex combs on the second leg (L2-L1) is strongly increased compared to flies harboring only the Pc¹ mutation. Flies transheterozygous for bur^k07130 and Pc¹ exhibit very strong wing-to-haltere transformations. In addition, males transheterozygous for bur^k07130 and Pc¹ also show partial transformation of the anterior abdominal segments A4 towards A5 and carry sex combs on the second legs. Flies transheterozygous for bur¹ and Pc¹ exhibit a 2-fold increase in the frequency of L2-L1 transformations, compared to heterozygous Pc¹ mutations.

(van der Knaap et al., 2005)

Pc¹/Snr1^E1 animals have incomplete L2, L4 and L5 wing veins (6%, 38% and 22% respectively) and moderate curling and disruption of the wing along the posterior wing margin.

(Marenda et al., 2004)

Mutants heterozygous for lolal^k02512, lolal^k11212, or lolal^k07907, when also heterozygous for Pc¹, exhibit a contrabithorax phenotype, which is a wing-to-haltere transformation due to ectopic expression of Ubx in the posterior part of the wing disc. This phenotype is further enhanced in specific lolal heteroallelic viable combinations, such as lolal^k02512/lolal^311a, lolal^k11212/lolal^311a, and lolal^k07907/lolal^311a, when also heterozygous for Pc¹.

(Faucheux et al., 2003)

The addition of lolal^k02512/+ to heterozygous Pc¹ animals produces crumbled wings with defective margin.

(Mishra et al., 2003)

Mutant weakly suppresses the CycE^JP rough eye phenotype.

(Brumby et al., 2002)

Pc¹ suppresses the pairing-dependent silencing of w^{enh.iab-7PRE.410} seen in flies homozygous for P{iab-7PRE-w^enh.410}2 but not in flies homozygous for P{iab-7PRE-w^enh.410}1. Pc¹ suppresses the pairing-dependent silencing of w^{enh.iab-7PRE.260} seen in flies homozygous for P{iab-7PRE-w^enh.260}1 or P{iab-7PRE-w^enh.260}2.

(Mishra et al., 2001)

Has little or no effect on the phenotype of E2f^GMR.PD Dp^GMR.PD BacA\p35^GMR.PH flies.

(Staehling-Hampton et al., 1999)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is exacerbated by combination with a single copy of Pc¹.

(Morimoto et al., 2016)

Complementation and Rescue Data

Rescued by

Pc¹ is rescued by Pc^{Tag:CS(TEVp),Tag:StrepII}

(Strübbe et al., 2011)

Comments

Images (0)

Mutant

Wild-type

Stocks (5)

Bloomington

1728

Pc¹/TM1

1729

Pc¹ Abd-B^Mc/TM3, Sb¹

Kyoto

106473

Pc¹/TM1

106474

Pc¹ Abd-B^Mc/TM3, Sb¹

103296

Df(3L)Pc Df(3R)bxd100, cp¹ in¹ kni^ri-1 Pc¹ p^p Ubx^bxd-100 / TM1, Me¹ kni^ri-1 Sb^sbd-l

Notes on Origin

Discoverer

P.H. Lewis.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

(Tariq et al., 2009)

Pc¹

(Inagaki et al., 2026, Shun Li et al., 2025, McPherson et al., 2023, Bi et al., 2022, Cheng et al., 2022, Liaw, 2022, Ponrathnam et al., 2021, Shaheen et al., 2021, Tauc et al., 2021, Verma et al., 2021, Fresán et al., 2020, Vaziri et al., 2020, Tian et al., 2019, Umer et al., 2019, Dardalhon-Cuménal et al., 2018, Mariappa et al., 2018, Song et al., 2018, Morimoto et al., 2016, Bivik et al., 2015, Kang et al., 2015, Singh and Mishra, 2015, Bengani et al., 2013, Debruhl et al., 2013, Schaaf et al., 2013, Vasanthi et al., 2013, Popkova et al., 2012, Rincon-Arano et al., 2012, Stern et al., 2012, Rodriguez-Jato et al., 2011, Strübbe et al., 2011, Sultana et al., 2011, Bhatia et al., 2010, Herz et al., 2010, Lamiable et al., 2010, Smulders-Srinivasan et al., 2010, Chalkley et al., 2008, Doheny et al., 2008, Lagarou et al., 2008, Parrish et al., 2007, Hirose et al., 2001)

pc¹

(Dufourt et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (75)

Report Sections

Open Close