p150-Spir, 38C.37, 38C.34
Wiscott-Aldrich syndrome protein (WASP) homology domain 2 (WH2) family - a maternal effect locus that affects both the dorsal-ventral and anterior-posterior axes of the Drosophila egg and embryo - required for localization of determinants within the developing oocyte
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
Gene model reviewed during 5.49
4.5, 2.7 (northern blot)
990, 585 (aa)
Interacts with bsk, Rho1, Rac1, Cdc42 and wash. Interacts with capu.
Phosphorylated by Jnk kinase (bsk).
Binds to actin monomers via the WH2 domain.
The Spir-box targets binding to intracellular membrane structures.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\spir using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\spir in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of spir Spir was sequence comparison ( date:000414 ).
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Area matching Drosophila EST AA390587.
spir mutant embryos exhibit an absence of posterior pole plasm, polar granules and pole cells. BicD,spir embryos exhibit a duplication of the posterior telson at the anterior: the posterior signal can be active at the anterior independent of spir function. spir is required specifically for the localization, not synthesis, of the posterior signal.
Mutations in maternal dorsal class gene spir do not interact with RpII140wimp.
Mutations at the spir locus cause defects in midoogenesis.
spir gene function affects dorsoventral and anteroposterior patterning.
spir plays a role in polar granule formation.