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FB2021_03, released June 15, 2021

Gene: Dmel\chif

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General Information
Symbol
Dmel\chif
Species
D. melanogaster
Name
chiffon
Annotation Symbol
CG5813
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000307
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Summary
chiffon (chif) encodes a protein associated with the origin recognition complex that binds to chromosomal origins of replication and is required for the initiation of cellular DNA replication. It is involved in DNA replication, chorion production, muscle homeostasis, and axon guidance. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

BG:DS09218.1 , Dbf4, BG:DS09218.2

Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:16,342,430..16,352,628 [-]
Recombination map
2-52
RefSeq locus
NT_033779 REGION:16342430..16352628
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein kinase activator activity
inferred from direct assay
(Stephenson et al., 2015)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables nucleic acid binding
inferred from electronic annotation with InterPro:IPR006572
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables protein serine/threonine kinase activator activity
inferred from biological aspect of ancestor with PANTHER:PTN002310337
(assigned by GO_Central )
(Gaudet et al., 2011)
enables zinc ion binding
inferred from electronic annotation with InterPro:IPR006572
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (9 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in chorion-containing eggshell formation
inferred from high throughput mutant phenotype
(Schupbach and Wieschaus, 1991)
involved_in eggshell chorion gene amplification
inferred from mutant phenotype
(Stephenson et al., 2015, Claycomb et al., 2004, Zhang and Tower, 2004, Landis and Tower, 1999)
involved_in histone H3 acetylation
inferred from direct assay
(Torres-Zelada et al., 2019)
involved_in muscle cell cellular homeostasis
inferred from mutant phenotype
(Kucherenko et al., 2011)
inferred from genetic interaction with FLYBASE:Dg; FB:FBgn0034072
(Kucherenko et al., 2011)
inferred from genetic interaction with FLYBASE:Dys; FB:FBgn0260003
(Kucherenko et al., 2011)
involved_in photoreceptor cell axon guidance
inferred from mutant phenotype
(Marrone et al., 2011)
involved_in positive regulation of DNA replication
inferred from mutant phenotype
(Stephenson et al., 2015)
involved_in positive regulation of protein kinase activity
inferred from direct assay
(Stephenson et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in positive regulation of nuclear cell cycle DNA replication
inferred from biological aspect of ancestor with PANTHER:PTN002310337
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of cell cycle phase transition
inferred from biological aspect of ancestor with PANTHER:PTN002310337
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
part_of Dbf4-dependent protein kinase complex
inferred from direct assay
(Stephenson et al., 2015)
part_of H3 histone acetyltransferase complex
inferred from direct assay
(Torres-Zelada et al., 2019)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of Dbf4-dependent protein kinase complex
inferred from biological aspect of ancestor with PANTHER:PTN002310337
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002310337
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
chiffon (chif) encodes a protein associated with the origin recognition complex that binds to chromosomal origins of replication and is required for the initiation of cellular DNA replication. It is involved in DNA replication, chorion production, muscle homeostasis, and axon guidance. [Date last reviewed: 2019-03-07]
Protein Function (UniProtKB)
May be involved in initiation of DNA replication; activation of the chorion gene origins. May have a role in eye and thoracic bristle development.
(UniProt, Q9NK54)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
chif: chiffon (T. Schupbach)
Female sterile, homozygous females lay eggs which have thin, fragile chorions and remain unfertilized.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\chif for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Multiphase exon postulated: this gene shares a region of coding sequence with an overlapping gene, but different reading frames are utilized in the overlapping coding region; overlap >20aa.

Gene model reviewed during 5.43

Gene model reviewed during 5.50

Complex/atypical overlap: Shares 5' UTR with downstream gene; in addition, one transcript isoform shares 3' UTR with downstream gene.

Gene model reviewed during 6.27

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
chif-RA
FBtr0080838
NM_078859
6624
1711
chif-RB
FBtr0080839
NM_165156
6575
1695
chif-RD
FBtr0321313
NM_001273570
6170
1695
chif-RE
FBtr0475053
NM_001382183
6575
576
Additional Transcript Data and Comments
Reported size (kB)

6.6, 6.5 (northern blot)

(Landis and Tower, 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
chif-PA
FBpp0080396
189.2
1711
8.73
NP_523583
AAF53530
chif-PB
FBpp0080397
188.0
1695
8.92
NP_723965
AAG22437
chif-PD
FBpp0302856
188.0
1695
8.92
NP_001260499
AGB93034
chif-PE
FBpp0423267
63.6
576
4.79
QJC20912
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1695 aa isoforms: chif-PB, chif-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

1711, 1695 (aa)

(Landis and Tower, 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\chif using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
head mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 2
organism
(Landis and Tower, 1999)
adult stage & oogenesis
nurse cell
(Landis and Tower, 1999)
follicle cell
(Landis and Tower, 1999)
adult stageoogenesis stage S10 -- S11
(Landis and Tower, 1999)
adult stageoogenesis stage S13 -- S14
(Landis and Tower, 1999)
Additional Descriptive Data

Abundant chif transcripts are detected in nurse cells in egg chambers. Low levels of chif transcripts are detected in follicle cells. chif transcripts are detected in egg chambers and very early embryos on northern blots indicating that they are maternally supplied to the embryo.

(Landis and Tower, 1999)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of Dbf4-dependent protein kinase complex
inferred from direct assay
(Stephenson et al., 2015)
part_of H3 histone acetyltransferase complex
inferred from direct assay
(Torres-Zelada et al., 2019)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\chif in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 19 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of chif
Transgenic constructs containing regulatory region of chif
Aberrations (Deficiencies and Duplications) ( 67 )
Inferred from experimentation ( 67 )
Gene disrupted in
Df(2L)BSC781
(Kahsai and Cook, 2018, Kahsai et al., 2016, Christensen et al., 2009.5.6)
Df(2L)cact-255rv64
(Dawson et al., 1995, Tower et al., 1993)
Df(2L)Exel7065
(Ryder, 2004.4.26)
Df(2L)k04216-rv2
(Roote, 2000.6.13)
Df(2L)k04216-rv3
(Roote, 2000.6.13)
Df(2L)k08106-rv4
(Roote, 2000.6.13)
Df(2L)k08106-rv6
(Roote, 2000.6.13, Roote, 1999.7.7)
Df(2L)k08106-rv15
(Roote, 2000.6.13, Roote, 1999.7.7)
Df(2L)k14608-mr23
(Roote, 2000.6.13)
Df(2L)k17027rv2
(Roote, 2000.6.13)
Df(2L)r10
(Schupbach and Wieschaus, 1991, Ashburner et al., 1990)
Df(2L)RA5
(Levine et al., 2007, Eberl et al., 1998, Roote, 1996.8, Ashburner et al., 1990)
Df(2L)RM5
(Ashburner et al., 1990)
Df(2L)RN2
(Eberl et al., 1998, Dawson et al., 1995, Ashburner et al., 1990)
Df(2L)TE35D-16
(Ashburner et al., 1990)
Df(2L)TE35D-21
(Roote, 1996.8, Dawson et al., 1995, Ashburner et al., 1990)
Df(2L)TE35D-23
(Ashburner et al., 1990)
Gene not disrupted in
Df(2L)64j
(Ashburner et al., 1990)
Df(2L)A72
(Ashburner et al., 1990)
Df(2L)A267
(Ashburner et al., 1990)
Df(2L)ARR1
(Ashburner et al., 1990)
Df(2L)b80e4
(Ashburner et al., 1990)
Df(2L)el20
(Ashburner et al., 1990)
Df(2L)el28
(Ashburner et al., 1990)
Df(2L)fn12
(Ashburner et al., 1990)
Df(2L)fn26
(Ashburner et al., 1990)
Df(2L)fn27
(Ashburner et al., 1990)
Df(2L)H20
(Ashburner et al., 1990)
Df(2L)H60-3
(Roote, 1996.1.11, Roote, 1996.8, Dawson et al., 1995)
Df(2L)II30
(Roote, 1996.8)
Df(2L)III18
(Roote, 1996.8)
Df(2L)MN-I
(Levine et al., 2007)
Df(2L)n78l3
(Ashburner et al., 1990)
Df(2L)noc11
(Ashburner et al., 1990)
Df(2L)osp29
(Eberl et al., 1998)
Df(2L)osp38
(Ashburner et al., 1990)
Df(2L)rd9
(Ashburner et al., 1990)
Df(2L)Sco7
(Ashburner et al., 1990)
Df(2L)Scorv16
(Ashburner et al., 1990)
Df(2L)Scorv18
(Ashburner et al., 1990)
Df(2L)Scorv19
(Ashburner et al., 1990)
Df(2L)Scorv25
(Ashburner et al., 1990)
Df(2L)SS1
(Ashburner et al., 1990)
Df(2L)TE35BC-3
(Ashburner et al., 1990)
Df(2L)TE35BC-4
(Ashburner et al., 1990)
Df(2L)TE35BC-34
(Ashburner et al., 1990)
Df(2L)TE35D-1
(Ashburner et al., 1990)
Df(2L)TE35D-2
(Ashburner et al., 1990)
Df(2L)TE35D-3
(Ashburner et al., 1990)
Df(2L)TE35D-4
(Ashburner et al., 1990)
Df(2L)TE35D-6
(Ashburner et al., 1990)
Df(2L)TE35D-13
(Eberl et al., 1998, Dawson et al., 1995, Ashburner et al., 1990)
Df(2L)TE35D-14
(Eberl et al., 1998, Ashburner et al., 1990)
Df(2L)TE35D-15
(Ashburner et al., 1990)
Df(2L)TE35D-19
(Ashburner et al., 1990)
Df(2L)TE35D-20
(Ashburner et al., 1990)
Df(2L)TE35D-22
(Ashburner et al., 1990)
In(2L)dpps22Ldppd36R
(Ashburner et al., 1990)
In(2L)el18
(Eberl et al., 1998, Dawson et al., 1995, Ashburner et al., 1990)
In(2LR)Scorv1-DV7
(Ashburner et al., 1990)
T(2;3)Scorv7
(Ashburner et al., 1990)
Gene duplicated in
Dp(2;3)osp3
(Ashburner et al., 1990)
Gene not duplicated in
Dp(2;1)Scorv23
(Ashburner et al., 1990)
Dp(2;2)GYL
(Ashburner et al., 1990)
Dp(2;2)TE35B-54L
(Ashburner et al., 1990)
In(2L)C163.41LC158R
(Ashburner et al., 1990)
In(2L)Scorv17LC158R
(Ashburner et al., 1990)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with chifDsRed)
lethal (with chifETBE3)
lethal (with Df(2L)RA5)
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile
female sterile (with Df(2L)BSC781)
female sterile | recessive
fertile, with chif1-375.Tag:HA,Tag:FLAG, chifDsRed/chifETBE3
fertile, with chif401-1695.Tag:HA,Tag:FLAG, chifDsRed/chifETBE3
fertile, with chifDsRed/chifETBE3
fertile, with Df(2L)RA5/chifDsRed
fertile, with Df(2L)RA5/chifETBE3
fertile (with chifDsRed), with chif1-375.Tag:HA,Tag:FLAG, chif401-1695.Tag:HA,Tag:FLAG
fertile (with chifDsRed), with chif1-1695.Tag:HA,Tag:FLAG
fertile (with chifDsRed), with chif376aa.Tag:HA,Tag:FLAG
fertile (with chifETBE3), with chif1-375.Tag:HA,Tag:FLAG, chif401-1695.Tag:HA,Tag:FLAG
fertile (with chifETBE3), with chif1-1695.Tag:HA,Tag:FLAG
fertile (with chifETBE3), with chif376aa.Tag:HA,Tag:FLAG
fertile (with Df(2L)RA5), with chif1-1695.Tag:HA,Tag:FLAG
fertile (with Df(2L)RA5), with chif376aa.Tag:HA,Tag:FLAG
sterile, with chifDsRed/chifETBE3
sterile, with Df(2L)RA5/chifDsRed
sterile, with Df(2L)RA5/chifETBE3
sterile (with chifDsRed), with chif401-1695.Tag:HA,Tag:FLAG
sterile (with chifDsRed), with chifWF24.Tag:HA,Tag:FLAG
sterile (with chifETBE3), with chif401-1695.Tag:HA,Tag:FLAG
sterile (with chifETBE3), with chifWF24.Tag:HA,Tag:FLAG
sterile (with Df(2L)RA5), with chif401-1695.Tag:HA,Tag:FLAG
sterile (with Df(2L)RA5), with chifWF24.Tag:HA,Tag:FLAG
Other Phenotypes
Allele
abnormal locomotor behavior | dominant | temperature conditional
abnormal neuroanatomy | third instar larval stage
decreased occurrence of cell division | somatic clone
increased cell death | oogenesis | oogenesis | somatic clone
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
visible, with Scer\GAL4pnr-MD237
visible | recessive
wild-type
Phenotype manifest in
Allele
axon | third instar larval stage
egg chorion
eye
follicle cell | somatic clone
indirect flight muscle (with chifA507)
indirect flight muscle (with chifBG02820a)
indirect flight muscle (with chifEY05746)
lamina plexus | third instar larval stage
oocyte | somatic clone
scutellar bristle
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\DBF4B
9 of 15
Yes
Yes
Hsap\DBF4
8 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Dbf4
9 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Dbf4
3 of 13
Yes
Yes
Rnor\Dbf4b
1 of 13
No
Yes
Rnor\LOC103690019
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\dbf4
8 of 12
Yes
Yes
Xtro\dbf4b
5 of 12
No
Yes
Danio rerio (Zebrafish) (2)
Drer\dbf4
7 of 15
Yes
Yes
Drer\dbf4b
6 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\DBF4
6 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\dfp1
4 of 12
Yes
Yes
Spom\spo6
2 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900RO )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000465
Drosophila simulans
Dsim\GD21913
Drosophila sechellia
Dsec\GM17902
Drosophila erecta
Dere\GG20129
Drosophila yakuba
Dyak\GE12819
Drosophila ananassae
Dana\GF26853
Drosophila pseudoobscura pseudoobscura
Dpse\GA19150
Drosophila persimilis
Dper\GL18484
Drosophila willistoni
Dwil\GK27867
Drosophila virilis
Dvir\GJ17456
Drosophila mojavensis
Dmoj\GI13857
Drosophila grimshawi
Dgri\GH25033
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500GJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011471
Glossina morsitans
Tsetse fly
Gmor\GMOY005841
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00468
Mayetiola destructor
Hessian fly
Mdes\Mdes013977
Mayetiola destructor
Hessian fly
Mdes\Mdes002937
Mayetiola destructor
Hessian fly
Mdes\Mdes002930
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03Q1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009897
Danaus plexippus
Monarch butterfly
Dple\DPOGS200841-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL003530
Apis florea
Little honeybee
Aflo\2840650276
Apis mellifera
Western honey bee
Amel\GB43217
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22887
Bombus terrestris
Buff-tailed bumblebee
Bter\15210479
Linepithema humile
Argentine ant
Lhum\LH22020
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0000a9
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012102
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10083
Tribolium castaneum
Red flour beetle
Tcas\TC011991
Pediculus humanus
Human body louse
Phum\PHUM257200
Pediculus humanus
Human body louse
Phum\PHUM257090
Rhodnius prolixus
Kissing bug
Rpro\RPRC010006
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009837
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15442
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03N5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013290
Strigamia maritima
European centipede
Smar\SMAR011757
Ixodes scapularis
Black-legged tick
Isca\ISCW015781
Ixodes scapularis
Black-legged tick
Isca\ISCW015530
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g02510
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_98359
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G116A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_025495gn
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    DBF4B; DBF4 zinc finger B
    9 of 15
    611661
        DBF4; DBF4 zinc finger
        8 of 15
        604281
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Dg
            enhanceable
            chif
            (Kucherenko et al., 2011, Kucherenko et al., 2008)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-52
            Cytogenetic map
            35F1-35F12
            Sequence location
            2L:16,342,430..16,352,628 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            35F1-35F12
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            35F-36A
            (Landis, 1999.6.10)
            35F11-35F12
            (determined by in situ hybridisation)
            (Ashburner et al., 1999)
            35F11-35F12
            (BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location

            2-52

            (FlyBase, 2016)

            2-49.7

            (Comeron et al., 2012)

            2-53

            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (17)
            Genomic Clones (30)
            cDNA Clones (50)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for database merge of

              Source for merge of: chif CG5817

              (FlyBase, 1996-)
              Additional comments

              Sequences corresponding to the 5' end of release 2 CG18115 overlap the 3' end of release 3 chif transcript CG5813-RA.

              (FlyBase Genome Annotators, 2002-2003)

              Release 1 annotation CG5817 overlaps part of the release 3.2 annotation for chif (CG5813).

              (FlyBase, 1996-)
              Other Comments

              The Hrp59 protein binds preferentially to a subset of mRNAs, including chif mRNA.

              (Kiesler et al., 2005)

              Hypomorphic mutations in chif cause thin, fragile chorions and female sterility, and eliminate chorion gene amplification. Null alleles have the additional phenotypes of rough eyes and thin thoracic bristles; phenotypes often associated with disruption of the normal cell cycle.

              (Landis and Tower, 1999)

              chif is involved in processes in addition to chorion gene amplification.

              (Landis and Tower, 1995)

              Mutations at the chif locus cause defects in midoogenesis.

              (Schupbach and Wieschaus, 1991)

              5 alleles are discussed but are not named.

              (Ashburner et al., 1990)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 62 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DRscDB
              EMBL-EBI Single Cell Expression Atlas
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL
              modMine - A data warehouse for the modENCODE project
              Linkouts
              ApoDroso - Functional genomic database for photoreceptor development, survival and function
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Synonyms and Secondary IDs (12)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (91)