FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\ken
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General Information
Symbol
Dmel\ken
Species
D. melanogaster
Name
ken and barbie
Annotation Symbol
CG5575
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011236
Gene Model Status
Current
Stock Availability
19 publicly available
Gene Summary
ken and barbie (ken) encodes a transcription factor involved in genital formation. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Ken & Barbie, okina, ok

Key Links
Genomic Location
Cytogenetic map
60A6-60A7
Sequence location
Recombination map
2-105
RefSeq locus
NT_033778 REGION:23870273..23877442
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables DNA binding
inferred from mutant phenotype
(Lukacsovich et al., 2003)
enables DNA-binding transcription factor activity
inferred from mutant phenotype
(Arbouzova et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from biological aspect of ancestor with PANTHER:PTN001905569
(GO Reference Genome Project, 2011-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN001905569
(GO Reference Genome Project, 2011-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in female analia development
inferred from mutant phenotype
(Lukacsovich et al., 2003)
involved_in female genitalia development
inferred from mutant phenotype
(Lukacsovich et al., 2003)
involved_in male analia development
inferred from mutant phenotype
(Lukacsovich et al., 2003)
involved_in male genitalia development
inferred from mutant phenotype
(Lukacsovich et al., 2003)
involved_in negative regulation of receptor signaling pathway via JAK-STAT
inferred from mutant phenotype
(Arbouzova et al., 2006)
involved_in regulation of DNA-templated transcription
inferred from mutant phenotype
(Arbouzova et al., 2006, Lukacsovich et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001905569
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Lukacsovich et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001905569
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
ken and barbie (ken) encodes a transcription factor involved in genital formation. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Pathway (FlyBase)
NEGATIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY -
Negative regulators of JAK-STAT signaling down-regulate the pathway, attenuating transcriptional control by Stat92E.
Protein Function (UniProtKB)
Transcription factor required for terminalia development. Negative regulator of the JAK/STAT pathway: represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles.
(UniProt, O77459)
Summary (Interactive Fly)

BTB-POZ domain transcription factor with C-terminal zinc finger - recruits NURF by physical interaction to engender transcriptional repression - involved in genital disc development

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\ken for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O77459)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ken-RA
FBtr0072129
NM_079109
3070
601
Additional Transcript Data and Comments
Reported size (kB)

3.0 (northern blot)

(Lukacsovich et al., 1999)

3.2 (northern blot)

(Kuhnlein et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
ken-PA
FBpp0072038
67.0
601
7.07
O77459
NP_523833
AAF47084
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

601 (aa)

(Lukacsovich et al., 1999, Kuhnlein et al., 1998)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ken using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.43

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval posterior spiracle
(Kuhnlein et al., 1998)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 5
organism | 60% egg length

Comment: 64% egg length

(Kuhnlein et al., 1998)
embryonic stage 5 -- 7
organism | 20% egg length

Comment: 17% egg length

(Kuhnlein et al., 1998)
embryonic stage 7 -- 8
dorsal ectoderm
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
inclusive hindgut primordium
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic anal pad
(Fisher et al., 2012)
embryonic dorsal apodeme
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic ventral apodeme
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval posterior spiracle
(Fisher et al., 2012)
embryonic stage 16
embryonic/larval proventriculus
(Kuhnlein et al., 1998)
anal pad
(Kuhnlein et al., 1998)
dorsal pouch
(Kuhnlein et al., 1998)
embryonic/larval foregut
(Kuhnlein et al., 1998)
embryonic/larval hindgut
(Kuhnlein et al., 1998)
tracheal system
(Kuhnlein et al., 1998)
oogenesis
border follicle cell
(Wang et al., 2006)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Lukacsovich et al., 2003)
embryonic stage 5
organism | 20% egg length | 70% egg length
(Lukacsovich et al., 2003)
embryonic stage 6 -- 7
cephalic furrow | posterior to
(Lukacsovich et al., 2003)
embryonic stage 6 -- 15
embryonic hindgut
(Lukacsovich et al., 2003)
embryonic stage 15
anal pad
(Lukacsovich et al., 2003)
embryonic foregut
(Lukacsovich et al., 2003)
third instar larval stage
genital disc
(Lukacsovich et al., 2003)
eye-antennal disc
(Lukacsovich et al., 2003)
adult stage
organism
(Lukacsovich et al., 2003)
Additional Descriptive Data

ken expression is enriched in border follicle cells relative to other cells in the egg chamber.

(Wang et al., 2006)

Northern analysis indicates that expression of ken is higher during embryonic and pupal stages than in larval stages. Expression of ken is higher in adult females than in males. ken transcript is expressed ubiquitously in both male and female genital discs and eye-antennal discs. In the embryo ken transcript is detected in stage 5 blastoderm embryos as 2 stripes at 64% and 17% egg length. Expression is stronger with the anterior expression just posterior to the cephalic furrow and posterior expression confined to the hindgut primordium. Anterior expression disappears by stage 9 and then reappears in the foregut at stage 15. Posterior expression is confined to the hindgut and anal pad.

(Lukacsovich et al., 2003)

ken transcripts are first detected in early stage 5 embryos in two circumferential rings around the embryo at 17% and 64% egg length. At the end of stage 5, they co-localize with the first and seventh ftz stripes. The anterior stripe fades while the staining in the posterior domain persists until the end of embyrogenesis in the posterior spiracles. Expression is also observed at stage 16 in the foregut, the proventriculus, the dorsal pouch, the hindgut, and the anal pads.

(Kuhnlein et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Lukacsovich et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ken in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 25 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ken
Transgenic constructs containing regulatory region of ken
Aberrations (Deficiencies and Duplications) ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Bx-MS1096
lethal, with Scer\GAL4pnr-MD237
lethal | dominant
lethal | recessive
lethal - all die before end of first instar larval stage (with Df(2R)or-BR11)
lethal - all die before end of first instar larval stage | recessive
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage (with Df(2R)Chig230)
partially lethal - majority die
Other Phenotypes
Allele
abnormal locomotor behavior | adult stage
abnormal locomotor behavior | adult stage (with Df(2R)or-BR11)
abnormal locomotor behavior | adult stage (with ken1)
abnormal locomotor behavior | adult stage (with ken141)
abnormal neurophysiology | adult stage
abnormal neurophysiology | adult stage (with ken1)
abnormal neurophysiology | adult stage (with ken141)
abnormal phototaxis | adult stage
abnormal phototaxis | adult stage (with Df(2R)or-BR11)
abnormal phototaxis | adult stage (with ken1)
abnormal phototaxis | adult stage (with ken141)
some die during pupal stage
some die during pupal stage (with Df(2R)Chig230)
visible
visible | adult stage (with ken1)
visible | adult stage (with ken141)
visible | somatic clone
Phenotype manifest in
Allele
aedeagus
antenna
antenna (with Df(2R)Chig230)
arista
arista | adult stage (with ken1)
arista | adult stage (with ken141)
female analia
female genitalia
genitalia
genitalia (with Df(2R)Chig230)
genitalia | adult stage (with ken1)
genitalia | adult stage (with ken141)
giant fiber neuron | adult stage
giant fiber neuron | adult stage (with ken1)
giant fiber neuron | adult stage (with ken141)
hypogynium
male genital disc (with ken1)
male genital disc (with kenok)
male genitalia
oviprovector
rhabdomere R7, with Scer\GAL4Rh3.PP
surstylus
terminalia (with ken1)
terminalia (with ken00628)
terminalia (with ken02970)
terminalia (with kenok)
tracheal pit, with Scer\GAL4da.G32
wing (with ken1)
wing (with ken141)
wing margin bristle | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (19)
Hsap\ABTB1
1 of 14
Yes
Yes
Hsap\BCL11A
1 of 14
Yes
No
Hsap\BCL11B
1 of 14
Yes
No
Hsap\KBTBD3
1 of 14
Yes
No
Hsap\KBTBD4
1 of 14
Yes
No
Hsap\KLHL21
1 of 14
Yes
No
Hsap\KLHL30
1 of 14
Yes
No
Hsap\MYNN
1 of 14
Yes
No
Hsap\ZBTB6
1 of 14
Yes
No
Hsap\ZBTB8A
1 of 14
Yes
Yes
Hsap\ZBTB8B
1 of 14
Yes
Yes
Hsap\ZBTB14
1 of 14
Yes
No
Hsap\ZBTB21
1 of 14
Yes
No
Hsap\ZBTB24
1 of 14
Yes
No
1  
Hsap\ZBTB44
1 of 14
Yes
No
Hsap\ZBTB46
1 of 14
Yes
Yes
Hsap\ZNF131
1 of 14
Yes
No
Hsap\ZNF296
1 of 14
Yes
Yes
Hsap\ZNF524
1 of 14
Yes
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (6)
Rnor\Bcl11a
1 of 14
Yes
No
Rnor\Bcl11b
1 of 14
Yes
No
Rnor\Zbtb8a
1 of 14
Yes
Yes
Rnor\Zbtb8b
1 of 14
Yes
Yes
Rnor\Zbtb46
1 of 14
Yes
Yes
Rnor\Zfp296
1 of 14
Yes
Yes
Mus musculus (laboratory mouse) (7)
Mmus\Zbtb46
2 of 14
Yes
Yes
Mmus\Bcl11a
1 of 14
No
No
Mmus\Bcl11b
1 of 14
No
No
Mmus\Zbtb8a
1 of 14
No
Yes
Mmus\Zbtb8b
1 of 14
No
Yes
Mmus\Zfp296
1 of 14
No
Yes
Mmus\Zfp597
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (13)
Xtro\bcl11a
1 of 13
Yes
No
Xtro\btbd18
1 of 13
Yes
No
Xtro\klhl21
1 of 13
Yes
No
Xtro\klhl40
1 of 13
Yes
No
Xtro\pou5f3.1
1 of 13
Yes
Yes
Xtro\zbtb6
1 of 13
Yes
Yes
Xtro\zbtb8a.1
1 of 13
Yes
Yes
Xtro\zbtb8a.2
1 of 13
Yes
Yes
Xtro\zbtb8b
1 of 13
Yes
Yes
Xtro\zbtb14
1 of 13
Yes
Yes
Xtro\zbtb41
1 of 13
Yes
No
Xtro\zbtb43
1 of 13
Yes
No
Xtro\zbtb46
1 of 13
Yes
Yes
Danio rerio (Zebrafish) (10)
Drer\bcl11aa
1 of 14
Yes
No
Drer\bcl11ab
1 of 14
Yes
No
Drer\bcl11ba
1 of 14
Yes
No
Drer\bcl11bb
1 of 14
Yes
No
Drer\si:dkey-7l6.3
1 of 14
Yes
Yes
Drer\zbtb8a
1 of 14
Yes
Yes
Drer\zbtb8b
1 of 14
Yes
Yes
Drer\zbtb46
1 of 14
Yes
Yes
Drer\znf296
1 of 14
Yes
No
Drer\znf362a
1 of 14
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\eor-1
1 of 14
Yes
No
Cele\kel-3
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (27)
Agam\AgaP_AGAP004767
10 of 12
Yes
Yes
Agam\AgaP_AGAP000080
1 of 12
No
No
Agam\AgaP_AGAP000585
1 of 12
No
No
Agam\AgaP_AGAP001073
1 of 12
No
No
Agam\AgaP_AGAP001258
1 of 12
No
Yes
Agam\AgaP_AGAP001646
1 of 12
No
No
Agam\AgaP_AGAP002165
1 of 12
No
No
Agam\AgaP_AGAP002303
1 of 12
No
No
Agam\AgaP_AGAP003189
1 of 12
No
No
Agam\AgaP_AGAP003286
1 of 12
No
No
Agam\AgaP_AGAP003428
1 of 12
No
No
Agam\AgaP_AGAP003439
1 of 12
No
No
Agam\AgaP_AGAP003537
1 of 12
No
No
Agam\AgaP_AGAP003685
1 of 12
No
No
Agam\AgaP_AGAP005244
1 of 12
No
No
Agam\AgaP_AGAP005245
1 of 12
No
No
Agam\AgaP_AGAP005747
1 of 12
No
No
Agam\AgaP_AGAP005748
1 of 12
No
No
Agam\AgaP_AGAP006018
1 of 12
No
No
Agam\AgaP_AGAP006454
1 of 12
No
No
Agam\AgaP_AGAP008031
1 of 12
No
No
Agam\AgaP_AGAP008506
1 of 12
No
No
Agam\AgaP_AGAP010063
1 of 12
No
No
Agam\AgaP_AGAP010355
1 of 12
No
No
Agam\AgaP_AGAP011247
1 of 12
No
No
Agam\AgaP_AGAP011583
1 of 12
No
No
Agam\AgaP_AGAP011902
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\GIS1
1 of 13
Yes
No
Scer\RPH1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\prz1
1 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:ken. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (27)
ab
1 of 13
bab1
1 of 13
bab2
1 of 13
br
1 of 13
BtbVII
1 of 13
CG6118
1 of 13
CG6654
1 of 13
CG6765
1 of 13
CG8924
1 of 13
CG12236
1 of 13
CG15812
1 of 13
CG30431
1 of 13
CG34376
1 of 13
chinmo
1 of 13
Cph
1 of 13
fru
1 of 13
lolal
1 of 13
lola
1 of 13
lov
1 of 13
mamo
1 of 13
mod(mdg4)
1 of 13
psq
1 of 13
rdx
1 of 13
rib
1 of 13
tono
1 of 13
Trl
1 of 13
ttk
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    ken
    enhanceable
    cad
    (Lukacsovich et al., 2003)
    ken
    enhanceable
    dpp
    (Lukacsovich et al., 2003)
    ken
    enhanceable
    tll
    (Lukacsovich et al., 2003)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Su(var)3-3
    suppressible
    ken
    (Eliazer et al., 2014)
    wg
    suppressible
    ken
    (McClure and Schubiger, 2008)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-105
    Cytogenetic map
    60A6-60A7
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    60A6-60A7
    Limits computationally determined from genome sequence between P{lacW}eIF6k13214 and P{lacW}kenk11035&P{EP}CG17658EP730
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    60A-60A
    (Kühnlein, 1998.11.2)
    60A5-60A9
    (determined by in situ hybridisation)
    (Spradling et al., 1999)
    60A8-60A11
    60A5--9
    (Beaton, 1997.12.27)
    60A1-60A16
    60A5--9 60A8--11
    (BDGP Project Members, 1994-1999)
    Experimentally Determined Recombination Data
    Location

    2-105

    (FlyBase, 2016)

    2-109.6

    (Comeron et al., 2012)

    2-

    (Yamamoto et al., 1997)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (19)
    Genomic Clones (16)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (32)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Issigonis and Matunis, 2012)
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
      Other Comments

      S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

      (Stroschein-Stevenson et al., 2006)

      RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

      (Boutros et al., 2004)

      Mutants show malformation of adult terminalia.

      (Lukacsovich et al., 2003)

      Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

      (Harvie et al., 1998)

      Mutant homozygous males prematurely terminate copulation.

      (Yamamoto et al., 1997)

      Sperm transfer defect.

      (Castrillon et al., 1993)

      Locus originally described and named by C. Berg.

      Relationship to Other Genes
      Source for database merge of

      Source for merge of: ken okina

      (Lukacsovich et al., 2003, Lukacsovich et al., 1999)
      Additional comments
      Nomenclature History
      Source for database identify of

      Source for identity of: ken CG5575

      (Zhang, 1999.11)
      Nomenclature comments
      Etymology
      Synonyms and Secondary IDs (20)
      Reported As
      Symbol Synonym
      2970
      (Harvie et al., 1998)
      3907
      (Harvie et al., 1998)
      5029
      (Harvie et al., 1998)
      8253
      (Harvie et al., 1998)
      BCL-6/KEN
      (Castelli-Gair Hombria, 2006)
      CG5575
      (National Institute of Genetics Fly Stocks, 2022-, Schertel et al., 2013, Christis and Munro, 2012, Ni et al., 2010.12.1, Haussmann et al., 2008, Quinones-Coello, 2007, Arbouzova et al., 2006, Brandt, 2006, Kanuka et al., 2005)
      KEN
      (Arbouzova and Zeidler, 2006, Castelli-Gair Hombria, 2006)
      Ken
      (Bonchuk et al., 2024, Li et al., 2024, Lepesant et al., 2020, Peercy and Starz-Gaiano, 2020, Dorn and Dorn, 2015, Chen et al., 2014, Bausek, 2013, Mbodj et al., 2013, Morin-Poulard et al., 2013, Silver-Morse and Li, 2013, Matunis et al., 2012, Bonchuk et al., 2011, Kugler et al., 2011, Yoon et al., 2011, Kwon et al., 2008, Arbouzova, 2006, Arbouzova et al., 2006, Franchini et al., 2004)
      P420
      (Liebl, 1999)
      ken
      (Balakireva et al., 2024, Moriel et al., 2021, Ullastres et al., 2021, Winbush and Singh, 2021, Shokri et al., 2019, Bischof et al., 2018, Dove et al., 2017, Karaiskos et al., 2017, Field et al., 2016, Zhang et al., 2016, Baëza et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Nadimpalli et al., 2015, Schertel et al., 2015, Sîrbu et al., 2015, Eliazer et al., 2014, Bausek, 2013, Bonke et al., 2013, Schertel et al., 2013, Berger et al., 2012, Matunis et al., 2012, Grimberg et al., 2011, Levis et al., 2011.12.16, Weake et al., 2011, Yoon et al., 2011, Flaherty et al., 2009, Christensen et al., 2008.9.3, Christensen et al., 2008.12.28, Haussmann et al., 2008, Maeda et al., 2008, McClure and Schubiger, 2008, Allen et al., 2007, Baeg et al., 2007, Minidorff et al., 2007, Minidorff et al., 2007, Quinones-Coello, 2007, Arbouzova, 2006, Brandt, 2006, Bullock et al., 2006, Castelli-Gair Hombria, 2006, Stroschein-Stevenson et al., 2006, Kanuka et al., 2005)
      l(2)00628
      (Liebl, 1999)
      l(2)02970
      l(2)05029
      ok
      (Billeter et al., 2002, Yamamoto and Nakano, 1998)
      okina
      (Yamamoto et al., 1997)
      Name Synonyms
      Ken & Barbie
      (Maeng et al., 2012, Arbouzova, 2006, Arbouzova and Zeidler, 2006, Arbouzova et al., 2006)
      Ken and Barbie
      (Saadin and Starz-Gaiano, 2016, Morin-Poulard et al., 2013, Stec and Zeidler, 2011, Yoon et al., 2011, Castelli-Gair Hombria, 2006)
      ken & barbie
      (Arbouzova et al., 2006, Arbouzova et al., 2003)
      ken and barbie
      (Bausek, 2013, Matunis et al., 2012, Flaherty et al., 2009, McClure and Schubiger, 2008, Jordan et al., 2007)
      ken-and-barbie
      (Matunis et al., 2012, Kula-Eversole and Hatini, 2007, Wang et al., 2006)
      Secondary FlyBase IDs
      • FBgn0010464
      • FBgn0010525
      • FBgn0020522
      • FBgn0024882
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 56 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      FlyMine - An integrated database for Drosophila genomics
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      References (136)