FB2025_02 , released April 17, 2025
Gene: Dmel\Cbl
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General Information
Symbol
Dmel\Cbl
Species
D. melanogaster
Name
Cbl proto-oncogene
Annotation Symbol
CG7037
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020224
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

D-cbl, dCbl, D-cblL, D-cblS, cable

Key Links
Genomic Location
Cytogenetic map
66C12-66C12
Sequence location
Recombination map
3-24
RefSeq locus
NT_037436 REGION:8424954..8432246
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (32 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:drk; FB:FBgn0004638
(Wang and Pai, 2011)
enables receptor tyrosine kinase binding
inferred from physical interaction with FLYBASE:Egfr; FB:FBgn0003731,FLYBASE:Pvr; FB:FBgn0032006
(Jekely et al., 2005)
enables ubiquitin protein ligase activity
inferred from mutant phenotype
(Kim et al., 2017, Wang and Pai, 2011)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
enables calcium ion binding
inferred from electronic annotation with InterPro:IPR014741
(InterPro Project Members, 2004-)
enables phosphotyrosine residue binding
inferred from electronic annotation with InterPro:IPR024159
(InterPro Project Members, 2004-)
inferred from sequence model
(Hime et al., 1997)
enables receptor tyrosine kinase binding
inferred from biological aspect of ancestor with PANTHER:PTN000544009
(GO Reference Genome Project, 2011-)
enables ubiquitin protein ligase activity
inferred from biological aspect of ancestor with PANTHER:PTN001124099
(GO Reference Genome Project, 2011-)
enables ubiquitin-protein transferase activity
inferred from sequence or structural similarity with UniProtKB:Q9ULV8
(Gene Ontology Curators, 2002-)
inferred from electronic annotation with InterPro:IPR024162
(InterPro Project Members, 2004-)
enables zinc ion binding
inferred from sequence model
(Ying et al., 2011)
Biological Process (21 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
involved_in dorsal/ventral axis specification, ovarian follicular epithelium
inferred from mutant phenotype
(Pai et al., 2000)
involved_in dorsal/ventral axis specification
inferred from mutant phenotype
(Pai et al., 2000)
involved_in dorsal/ventral pattern formation
inferred from mutant phenotype
(Wang and Pai, 2011)
involved_in eye photoreceptor cell differentiation
inferred from direct assay
(Wang et al., 2008)
involved_in germ-line cyst formation
inferred from genetic interaction with FLYBASE:Fmr1; FB:FBgn0028734
(Epstein et al., 2009)
involved_in imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Dworkin and Gibson, 2006)
involved_in negative regulation of epidermal growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:drk; FB:FBgn0004638
(Wang and Pai, 2011)
inferred from mutant phenotype
(Kim et al., 2017, Wang et al., 2008, Pai et al., 2006, Pai et al., 2000)
inferred from genetic interaction with FLYBASE:grk; FB:FBgn0001137
(Chang et al., 2008)
inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366
(Robertson et al., 2000)
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
(Meisner et al., 1997)
involved_in negative regulation of ERK1 and ERK2 cascade
inferred from genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205
(Robertson et al., 2000)
involved_in negative regulation of hormone biosynthetic process
inferred from mutant phenotype
(Yu et al., 2012)
involved_in negative regulation of Notch signaling pathway
inferred from mutant phenotype
(Bala Tannan et al., 2018, Wang et al., 2010)
inferred from genetic interaction with FLYBASE:N; FB:FBgn0004647
(Wang et al., 2010)
inferred from direct assay
(Bala Tannan et al., 2018)
acts_upstream_of positive regulation of apoptotic process
inferred from direct assay
(Wang et al., 2008)
involved_in positive regulation of border follicle cell migration
inferred from mutant phenotype
(Jekely et al., 2005)
involved_in positive regulation of receptor-mediated endocytosis
inferred from mutant phenotype
(Wang and Pai, 2011, Jekely et al., 2005)
inferred from genetic interaction with FLYBASE:shi; FB:FBgn0003392
(Pai et al., 2006)
involved_in protein monoubiquitination
inferred from mutant phenotype
(Kim et al., 2017)
involved_in R7 cell fate commitment
inferred from direct assay
(Wang et al., 2008)
involved_in regulation of carbohydrate metabolic process
inferred from mutant phenotype
(Yu et al., 2012)
involved_in regulation of cell population proliferation
inferred from genetic interaction with FLYBASE:Fmr1; FB:FBgn0028734
(Epstein et al., 2009)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in cell surface receptor signaling pathway
inferred from electronic annotation with InterPro:IPR003153, InterPro:IPR036537
(InterPro Project Members, 2004-)
involved_in negative regulation of epidermal growth factor receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN001124099
(GO Reference Genome Project, 2011-)
involved_in regulation of signaling
inferred from electronic annotation with InterPro:IPR024162
(InterPro Project Members, 2004-)
involved_in signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN001124099
(GO Reference Genome Project, 2011-)
involved_in ubiquitin-dependent protein catabolic process
inferred from sequence or structural similarity with UniProtKB:Q9ULV8
(Gene Ontology Curators, 2002-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
(Pai et al., 2006)
located_in cytoplasm
inferred from direct assay
(Hime et al., 1997)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in membrane raft
inferred from biological aspect of ancestor with PANTHER:PTN001124099
(GO Reference Genome Project, 2011-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001124099
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES -
This group comprises RING domain ubiquitin ligases that do not classify under other groups in FlyBase.
Negative Regulators of EGFR Signaling Pathway -
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Negative Regulators of Notch Signaling Pathway -
The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Negative regulators of the pathway down-regulate the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
Summary (Interactive Fly)

ubiquitin ligase - positively regulates receptor tyrosine ubiquitination accelerating degradation of ligand-receptor complexes - neuronal Cbl controls biosynthesis of insulin-like peptides

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Cbl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VSK2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cbl-RA
FBtr0076614
NM_168276
2948
448
Cbl-RB
FBtr0076615
NM_139967
4902
878
Additional Transcript Data and Comments
Reported size (kB)

2.5, 1.5 (northern blot)

(Hime et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Cbl-PA
FBpp0076341
51.5
448
7.80
O46034
NP_729382
AAF50417
Cbl-PB
FBpp0076342
94.8
878
7.35
Q9VSK2
NP_648224
AAF50416
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

448 (aa); 52 (kD observed)

(Hime et al., 1997)
Comments

Cbl protein lacks proline-rich sequences at the carboxy-terminus that are found in related proteins which allow binding to SH3-domain containing adaptor proteins. An in vitro protein interaction assay was used to show that Cbl protein does not interact with drk protein. It does, however associate with activated Egfr protein in vivo.

(Hime et al., 1997)
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cbl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.31

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012, Hime et al., 1997)
blastoderm stage
(Hime et al., 1997)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
third instar larval stage
imaginal disc
(Hime et al., 1997)
oogenesis
germarium

Comment: long isoform

(Pai et al., 2006)
follicle cell
(Pai et al., 2006)
nurse cell
(Pai et al., 2006)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 6
organism
(Hime et al., 1997)
embryonic stage 1 -- 12
organism

Comment: 0-8 hr AEL, peak at 0-2 hr AEL; short isoform

(Robertson et al., 2000)
embryonic stage 12 -- second instar larval stage
organism | faint

Comment: short isoform

(Robertson et al., 2000)
third instar larval stage
(Hime et al., 1997)
organism

Comment: short isoform

(Robertson et al., 2000)
P-stage
organism

Comment: long isoform

(Robertson et al., 2000)
adult stage | female
organism

Comment: long isoform; very faint in males

(Robertson et al., 2000)
Additional Descriptive Data

Both Cbl transcript isoforms are expressed during oogenesis. The long isoform can be detected in the germarium, while the short isoform becomes detectable in nurse and follicle cells at stage 5 of oogenesis; neither isoform is expressed in oocytes.

(Pai et al., 2006)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- larval stage
organism
(Pai et al., 2006)
blastoderm stage
(Hime et al., 1997)
embryonic stage 4 -- 12
organism
(Hime et al., 1997)
embryonic stage 15
Malpighian tubule
(Hime et al., 1997)
pharyngeal muscle cell
(Hime et al., 1997)
embryonic/larval hindgut
(Hime et al., 1997)
adult stage | female
ovary
(Pai et al., 2006)
Additional Descriptive Data

Both Cbl protein isoforms, as assayed by Western blot analysis, are expressed at all embryonic stages, all larval instars, and in ovaries. The short isoform is predominant at all stages.

(Pai et al., 2006)

Cbl protein was observed only in early embryos on Western blots. It is detected most strongly in blastoderm embryos by immunolocalization. At later stages, it is observed in pharyngeal muscle, hindgut and Malpighian tubules.

(Hime et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
(Pai et al., 2006)
located_in cytoplasm
inferred from direct assay
(Hime et al., 1997)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cbl in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cbl
Transgenic constructs containing regulatory region of Cbl
Aberrations (Deficiencies and Duplications) ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | pupal stage | recessive
lethal | recessive
lethal - all die before end of P-stage, with Scer\GAL4e22c
partially lethal - majority die
partially lethal - majority die, with Scer\GAL4e22c
partially lethal - majority die | male limited (with CblEY11427)
partially lethal - majority die | male limited (with CblKG03080)
partially lethal - majority die | recessive | third instar larval stage
viable
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal developmental rate | larval stage (with CblEY11427)
abnormal developmental rate | larval stage (with CblKG03080)
abnormal endomitotic cell cycle | adult stage | somatic clone
abnormal endomitotic cell cycle | third instar larval stage
abnormal neuroanatomy
abnormal oxidative stress response, with Scer\GAL4elav.PU
abnormal oxidative stress response | male limited, with Scer\GAL4Ilp2.PR
abnormal starvation stress response | male limited (with CblEY11427)
abnormal starvation stress response | male limited (with CblKG03080)
decreased cell death | somatic clone
increased body size | male limited, with Scer\GAL4elav.PU
increased body size | male limited, with Scer\GAL4Ilp2.PR
increased cell number | adult stage | somatic clone, with Scer\GAL4Tub.PU
increased cell number | third instar larval stage
increased occurrence of cell division | adult stage, with Scer\GAL4esg.PU, Scer\GAL80Su(H).GBE
increased occurrence of cell division | third instar larval stage
short lived, with Scer\GAL4elav.PU
short lived | male limited, with Scer\GAL4Ilp2.PR
short lived | male limited (with CblEY11427)
short lived | male limited (with CblKG03080)
some die during P-stage, with Scer\GAL4e22c
visible | dominant
Phenotype manifest in
Allele
abdominal tergite, with Scer\GAL4e22c
abdominal ventral denticle belt, with Scer\GAL4GR1
adult abdominal segment, with Scer\GAL4e22c
adult midgut epithelium | adult stage | somatic clone, with Scer\GAL4Tub.PU
anterior crossvein, with Scer\GAL4Bx-MS1096
border follicle cell | somatic clone
cephalopharyngeal skeleton
cephalopharyngeal skeleton | germline clone | rescuable maternal effect
cephalopharyngeal skeleton | maternal effect | somatic clone
cytoophidium | adult stage | female | somatic clone
cytoophidium | somatic clone | third instar larval stage
dorsal appendage, with Scer\GAL455B
dorsal appendage, with Scer\GAL4EQ1
dorsal appendage, with Scer\GAL4GR1
dorsal appendage, with Scer\GAL4hs.PB
dorsal appendage | maternal effect, with CblF165
dorsal appendage | maternal effect, with CblL.Hsp83
dorsal appendage | maternal effect | somatic clone
egg, with Scer\GAL455B
egg, with Scer\GAL4EQ1
egg, with Scer\GAL4GR1
egg chorion, with Scer\GAL455B
egg chorion, with Scer\GAL4EQ1
egg chorion, with Scer\GAL4GR1
egg chorion | maternal effect, with CblF165
egg chorion | maternal effect, with CblL.Hsp83
egg chorion | maternal effect | somatic clone
embryo | maternal effect | somatic clone
embryonic/first instar larval cuticle
eye, with Cbl1, Scer\GAL4GMR.PF
eye, with CblDv.UAS, Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PF
eye (with Cbl1), with Scer\GAL4GMR.PF
eye (with CblDv.UAS), with Scer\GAL4GMR.PF
eye | somatic clone
follicle cell | adult stage | somatic clone
hemocyte | third instar larval stage
intestinal stem cell | adult stage | somatic clone, with Scer\GAL4Tub.PU
neuron
ommatidium, with Cbl1, Scer\GAL4GMR.PF
ommatidium, with CblDv.UAS, Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4GMR.PF
ommatidium (with Cbl1), with Scer\GAL4GMR.PF
ommatidium (with CblDv.UAS), with Scer\GAL4GMR.PF
ommatidium | somatic clone
photoreceptor cell R7
photoreceptor cell R7, with Scer\GAL4GMR.PF
photoreceptor cell R7 | somatic clone
photoreceptor neuron | ectopic, with Cbl1, Scer\GAL4GMR.PF
photoreceptor neuron | ectopic, with CblDv.UAS, Scer\GAL4GMR.PF
photoreceptor neuron | ectopic (with Cbl1), with Scer\GAL4GMR.PF
photoreceptor neuron | ectopic (with CblDv.UAS), with Scer\GAL4GMR.PF
photoreceptor neuron | somatic clone
primary pigment cell | somatic clone
salivary gland | somatic clone | third instar larval stage
salivary gland | third instar larval stage
secondary pigment cell | somatic clone
tertiary pigment cell | somatic clone
ventral denticle belt | maternal effect | somatic clone
wing
wing | somatic clone
wing vein, with Scer\GAL4Bx-MS1096
wing vein, with Scer\GAL4GMR.PF
wing vein | ectopic, with CblF165
wing vein | ectopic, with CblS.Hsp83
wing vein | ectopic, with Scer\GAL4GMR.PF
wing vein | ectopic | somatic clone
wing vein L4, with Scer\GAL4Bx-MS1096
wing vein L5, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (39)
Hsap\CBL
10 of 14
Yes
Yes
Hsap\CBLB
9 of 14
No
Yes
1  
Hsap\CBLC
4 of 14
No
Yes
1  
Hsap\AMFR
1 of 14
No
No
Hsap\BRCA1
1 of 14
No
No
Hsap\CHFR
1 of 14
No
No
Hsap\COP1
1 of 14
No
Yes
Hsap\DTX3L
1 of 14
No
Yes
Hsap\DZIP3
1 of 14
No
Yes
Hsap\HLTF
1 of 14
No
No
Hsap\LONRF1
1 of 14
No
No
Hsap\LONRF2
1 of 14
No
No
Hsap\LONRF3
1 of 14
No
No
Hsap\PCGF2
1 of 14
No
No
1  
Hsap\PEX10
1 of 14
No
No
1  
Hsap\PHRF1
1 of 14
No
No
Hsap\RLIM
1 of 14
No
No
1  
Hsap\RNF4
1 of 14
No
No
Hsap\RNF5
1 of 14
No
No
1  
Hsap\RNF8
1 of 14
No
Yes
Hsap\RNF13
1 of 14
No
No
1  
Hsap\RNF113A
1 of 14
No
No
2  
Hsap\RNF114
1 of 14
No
Yes
Hsap\RNF126
1 of 14
No
No
1  
Hsap\RNF128
1 of 14
No
No
Hsap\RNF141
1 of 14
No
Yes
Hsap\RNF145
1 of 14
No
No
Hsap\RNF149
1 of 14
No
No
Hsap\RNF150
1 of 14
No
No
1  
Hsap\RNF180
1 of 14
No
Yes
Hsap\RNF185
1 of 14
No
No
2  
Hsap\RNF213
1 of 14
No
Yes
1  
Hsap\RNFT2
1 of 14
No
No
Hsap\TRIM11
1 of 14
No
Yes
Hsap\TRIM26
1 of 14
No
Yes
Hsap\TRIM31
1 of 14
No
Yes
Hsap\TRIM39
1 of 14
No
Yes
Hsap\TRIM50
1 of 14
No
Yes
Hsap\ZNRF4
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (22)
Rnor\Cblb
10 of 14
Yes
Yes
Rnor\Cbl
10 of 14
Yes
Yes
Rnor\Cblc
5 of 14
No
Yes
Rnor\Amfr
1 of 14
No
No
Rnor\Brca1
1 of 14
No
No
Rnor\Lonrf1
1 of 14
No
No
Rnor\Lonrf2
1 of 14
No
No
Rnor\Neurl3
1 of 14
No
No
Rnor\Pcgf2
1 of 14
No
No
Rnor\Rlim
1 of 14
No
No
Rnor\Rnf5
1 of 14
No
No
Rnor\Rnf114
1 of 14
No
Yes
Rnor\rnf141
1 of 14
No
Yes
Rnor\Rnf145
1 of 14
No
No
Rnor\Rnf150
1 of 14
No
No
Rnor\Rnf180
1 of 14
No
Yes
Rnor\Rnf185
1 of 14
No
No
Rnor\Trim11
1 of 14
No
Yes
Rnor\Trim26
1 of 14
No
Yes
Rnor\Trim31
1 of 14
No
Yes
Rnor\Trim39
1 of 14
No
No
Rnor\Trim50
1 of 14
No
Yes
Mus musculus (laboratory mouse) (27)
Mmus\Cblb
10 of 14
Yes
Yes
Mmus\Cbl
10 of 14
Yes
Yes
Mmus\Cblc
5 of 14
No
Yes
Mmus\Amfr
1 of 14
No
No
Mmus\Bfar
1 of 14
No
Yes
Mmus\Brca1
1 of 14
No
No
Mmus\Chfr
1 of 14
No
No
Mmus\Dtx3l
1 of 14
No
Yes
Mmus\Dzip3
1 of 14
No
Yes
Mmus\Hltf
1 of 14
No
No
Mmus\Lonrf1
1 of 14
No
No
Mmus\Lonrf2
1 of 14
No
No
Mmus\Pcgf2
1 of 14
No
No
Mmus\Rfwd3
1 of 14
No
No
Mmus\Rlim
1 of 14
No
No
Mmus\Rnf5
1 of 14
No
No
Mmus\Rnf8
1 of 14
No
Yes
Mmus\Rnf114
1 of 14
No
Yes
Mmus\Rnf141
1 of 14
No
Yes
Mmus\Rnf145
1 of 14
No
No
Mmus\Rnf150
1 of 14
No
No
Mmus\Rnf180
1 of 14
No
Yes
Mmus\Rnf185
1 of 14
No
No
Mmus\Trim11
1 of 14
No
Yes
Mmus\Trim26
1 of 14
No
No
Mmus\Trim39
1 of 14
No
Yes
Mmus\Zswim2
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (14)
Xtro\cblb
8 of 13
Yes
Yes
Xtro\cbl
8 of 13
Yes
Yes
Xtro\brca1
1 of 13
No
Yes
Xtro\cdpf1
1 of 13
No
No
Xtro\cox15
1 of 13
No
No
Xtro\mib1
1 of 13
No
No
Xtro\neurl3
1 of 13
No
No
Xtro\pex10
1 of 13
No
No
Xtro\rnf4
1 of 13
No
No
Xtro\rnf180
1 of 13
No
Yes
Xtro\topors
1 of 13
No
No
Xtro\trim69.1
1 of 13
No
No
Xtro\XB5729975
1 of 13
No
No
Xtro\xnf7
1 of 13
No
No
Danio rerio (Zebrafish) (24)
Drer\cblb
9 of 14
Yes
Yes
Drer\cbl
9 of 14
Yes
Yes
Drer\cblc
5 of 14
No
Yes
Drer\amfrb
1 of 14
No
No
Drer\btr01
1 of 14
No
Yes
Drer\btr20
1 of 14
No
Yes
Drer\btr21
1 of 14
No
Yes
Drer\chfr
1 of 14
No
No
Drer\cop1
1 of 14
No
Yes
Drer\dtx3l2.2
1 of 14
No
Yes
Drer\ftr57
1 of 14
No
No
Drer\ftr86
1 of 14
No
Yes
Drer\ftr97
1 of 14
No
No
Drer\hltf
1 of 14
No
No
Drer\obi1
1 of 14
No
Yes
Drer\pex10
1 of 14
No
No
Drer\rnf5
1 of 14
No
No
Drer\rnf103
1 of 14
No
Yes
Drer\rnf130
1 of 14
No
No
Drer\rnf141
1 of 14
No
Yes
Drer\rnf145b
1 of 14
No
No
Drer\rnf165b
1 of 14
No
No
Drer\rnf185
1 of 14
No
No
Drer\rnft1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\sli-1
11 of 14
Yes
Yes
Cele\C32D5.11
1 of 14
No
No
Cele\F10D7.5
1 of 14
No
No
Cele\F54B11.5
1 of 14
No
Yes
Cele\rnf-5
1 of 14
No
No
Cele\T22B2.1
1 of 14
No
Yes
Cele\trul-1
1 of 14
No
No
Cele\Y47G6A.31
1 of 14
No
No
Cele\Y52E8A.2
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (9)
Agam\AgaP_AGAP005449
10 of 12
Yes
Yes
Agam\AgaP_AGAP000736
1 of 12
No
Yes
Agam\AgaP_AGAP000928
1 of 12
No
No
Agam\AgaP_AGAP002028
1 of 12
No
No
Agam\AgaP_AGAP005643
1 of 12
No
No
Agam\AgaP_AGAP006041
1 of 12
No
No
Agam\AgaP_AGAP006900
1 of 12
No
No
Agam\AgaP_AGAP010697
1 of 12
No
No
Agam\AgaP_AGAP013233
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (83)
Atha\AIP2
1 of 13
Yes
No
Atha\AT1G04360
1 of 13
Yes
No
Atha\AT1G08050
1 of 13
Yes
Yes
Atha\AT1G11100
1 of 13
Yes
No
Atha\AT1G18660
1 of 13
Yes
No
Atha\AT1G19310
1 of 13
Yes
No
Atha\AT1G23980
1 of 13
Yes
No
Atha\AT1G24440
1 of 13
Yes
Yes
Atha\AT1G35330
1 of 13
Yes
No
Atha\AT1G49230
1 of 13
Yes
No
Atha\AT1G49850
1 of 13
Yes
No
Atha\AT1G55530
1 of 13
Yes
No
Atha\AT1G60360
1 of 13
Yes
No
Atha\AT1G68070
1 of 13
Yes
Yes
Atha\AT1G68180
1 of 13
Yes
No
Atha\AT1G72220
1 of 13
Yes
No
Atha\AT1G74990
1 of 13
Yes
No
Atha\AT2G03000
1 of 13
Yes
No
Atha\AT2G18670
1 of 13
Yes
No
Atha\AT2G20030
1 of 13
Yes
No
Atha\AT2G23780
1 of 13
Yes
No
Atha\AT2G27940
1 of 13
Yes
No
Atha\AT2G34990
1 of 13
Yes
No
Atha\AT2G35420
1 of 13
Yes
No
Atha\AT2G37580
1 of 13
Yes
Yes
Atha\AT2G42030
1 of 13
Yes
No
Atha\AT2G42350
1 of 13
Yes
No
Atha\AT2G42360
1 of 13
Yes
No
Atha\AT2G44410
1 of 13
Yes
No
Atha\AT3G02340
1 of 13
Yes
No
Atha\AT3G13430
1 of 13
Yes
No
Atha\AT3G18773
1 of 13
Yes
No
Atha\AT3G20010
1 of 13
Yes
No
Atha\AT3G26730
1 of 13
Yes
No
Atha\AT3G43430
1 of 13
Yes
Yes
Atha\AT3G48030
1 of 13
Yes
No
Atha\AT3G51325
1 of 13
Yes
No
Atha\AT3G58030
1 of 13
Yes
No
Atha\AT3G60080
1 of 13
Yes
No
Atha\AT4G01270
1 of 13
Yes
No
Atha\AT4G09100
1 of 13
Yes
No
Atha\AT4G09110
1 of 13
Yes
No
Atha\AT4G09120
1 of 13
Yes
No
Atha\AT4G09130
1 of 13
Yes
No
Atha\AT4G10150
1 of 13
Yes
No
Atha\AT4G10160
1 of 13
Yes
No
Atha\AT4G15975
1 of 13
Yes
No
Atha\AT4G17920
1 of 13
Yes
No
Atha\AT4G30400
1 of 13
Yes
No
Atha\AT4G40070
1 of 13
Yes
No
Atha\AT5G01960
1 of 13
Yes
No
Atha\AT5G03450
1 of 13
Yes
No
Atha\AT5G05130
1 of 13
Yes
No
Atha\AT5G17600
1 of 13
Yes
No
Atha\AT5G38895
1 of 13
Yes
No
Atha\AT5G43530
1 of 13
Yes
No
Atha\AT5G46650
1 of 13
Yes
No
Atha\AT5G52155
1 of 13
Yes
No
Atha\AT5G53910
1 of 13
Yes
Yes
Atha\ATCRT1
1 of 13
Yes
No
Atha\ATL3
1 of 13
Yes
No
Atha\ATL4
1 of 13
Yes
No
Atha\ATL4H
1 of 13
Yes
No
Atha\ATL6
1 of 13
Yes
No
Atha\ATL15
1 of 13
Yes
No
Atha\ATL63
1 of 13
Yes
No
Atha\BTS
1 of 13
Yes
No
Atha\CIP8
1 of 13
Yes
No
Atha\COP1
1 of 13
Yes
No
Atha\Hrd1A
1 of 13
Yes
No
Atha\Hrd1B
1 of 13
Yes
No
Atha\HUB1
1 of 13
Yes
No
Atha\PEX10
1 of 13
Yes
No
Atha\PRT1
1 of 13
Yes
No
Atha\RAD5
1 of 13
Yes
No
Atha\RHA1A
1 of 13
Yes
Yes
Atha\RHC1A
1 of 13
Yes
No
Atha\RMA1
1 of 13
Yes
No
Atha\RMA2
1 of 13
Yes
No
Atha\RMA3
1 of 13
Yes
No
Atha\VIM3
1 of 13
Yes
Yes
Atha\XBAT34
1 of 13
Yes
Yes
Atha\XBAT35
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\ASR1
1 of 13
Yes
No
Scer\IRC20
1 of 13
Yes
No
Scer\RAD5
1 of 13
Yes
No
Scer\SLX8
1 of 13
Yes
No
Scer\TUL1
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\brl2
1 of 12
Yes
No
Spom\hrd1
1 of 12
Yes
No
Spom\pas4
1 of 12
Yes
No
Spom\slx8
1 of 12
Yes
No
Spom\SPBC14F5.10c
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Cbl. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (16)
CG4325
1 of 13
CG6923
1 of 13
CG7694
1 of 13
CG8141
1 of 13
CG13605
1 of 13
CG32847
1 of 13
CG34308
1 of 13
dgrn
1 of 13
gol
1 of 13
mus302
1 of 13
neur
1 of 13
Pex10
1 of 13
sordd1
1 of 13
sordd2
1 of 13
Topors
1 of 13
Traf6
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    CBL; Cbl proto-oncogene
    model of  juvenile myelomonocytic leukemia
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CBL; Cbl proto-oncogene
    10 of 14
    165360
    CBLB; Cbl proto-oncogene B
    9 of 14
    604491
       
      CBLC; Cbl proto-oncogene C
      4 of 14
      608453
           
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Cbl
          enhanceable
          aos
          (Robertson et al., 2000)
          Cbl
          suppressible
          Ctps
          (Wang et al., 2015)
          Cbl
          enhanceable
          Dap160
          (Robertson et al., 2000)
          Cbl
          suppressible
          drk
          (Wang and Pai, 2011)
          Cbl
          suppressible
          Egfr
          (Yu et al., 2012, Robertson et al., 2000)
          Cbl
          enhanceable
          Egfr
          (Jekely et al., 2005, Robertson et al., 2000)
          Cbl
          suppressible
          grk
          (Jekely et al., 2005)
          Cbl
          enhanceable
          hyd
          (Robertson et al., 2000)
          Rbf|Cbl
          suppressible
          mir-998
          (Truscott et al., 2014)
          Cbl
          enhanceable
          Pvr
          (Jekely et al., 2005)
          Cbl
          suppressible
          shi
          (Pai et al., 2006)
          Cbl
          enhanceable
          shi
          (Robertson et al., 2000)
          Cbl
          enhanceable
          spri
          (Jekely et al., 2005)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          btl::Egfr
          suppressible
          Cbl
          (Wang and Pai, 2011, Pai et al., 2006)
          cindr
          enhanceable
          Cbl
          (Ketosugbo et al., 2017, Johnson et al., 2012)
          Ctps
          enhanceable
          Cbl
          (Wang et al., 2015)
          Egfr
          suppressible
          Cbl
          (Kim et al., 2017, Wang et al., 2008, Robertson et al., 2000)
          Fmr1
          suppressible
          Cbl
          (Epstein et al., 2009)
          hid
          suppressible
          Cbl
          (Wang et al., 2008)
          kis
          suppressible
          Cbl
          (Gervais et al., 2019)
          mop
          suppressible
          Cbl
          (Miura et al., 2008)
          Ras85D
          suppressible
          Cbl
          (Wang et al., 2008)
          Rbf
          enhanceable
          Cbl
          (Truscott et al., 2014)
          Rbf
          suppressible
          Cbl
          (Truscott et al., 2014)
          sev
          suppressible
          Cbl
          (Wang et al., 2008)
          Socs36E
          suppressible
          Cbl
          (Callus and Mathey-Prevot, 2002)
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3L
          Recombination map
          3-24
          Cytogenetic map
          66C12-66C12
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          66C12-66C12
          Limits computationally determined from genome sequence between P{lacW}l(3)L0139L0139 and P{PZ}Gug03928&P{EP}CG6745EP595b
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          66C-66C
          (Hime, 1997.12.22)
          66C-66C
          (determined by in situ hybridisation)
          (Hime et al., 1997)
          Experimentally Determined Recombination Data
          Location

          3-24

          (FlyBase, 2016)

          3-19.7

          (Comeron et al., 2012)

          3-24.5

          (Pai et al., 2000)
          Left of (cM)
          (Pai et al., 2000)
          Right of (cM)
          (Pai et al., 2000)
          Notes
          Stocks and Reagents
          Stocks (15)
          Genomic Clones (12)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (128)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Pai et al., 2006, Hime et al., 1997)
          Commercially Available Antibodies
           
          Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              Area matching Drosophila Cbl gene, Acc. No. U87925. This association is confirmed by overlap with Drosophila EST AA441040.

              (Davies, 2001.3.15)

              Cbl gene activity is required in the ventral follicle cells, and negatively regulates the Egfr pathway.

              (Pai and Schupbach, 2000)

              Mutations in Cbl produce dorsalised egg shells and embryos, and also cause an extra vein phenotype in the wing.

              (Pai and Schupbach, 2000)

              Cbl is a negative regulator of the Egfr pathway and is required for dorsoventral patterning in oogenesis.

              (Pai et al., 2000)

              Mutation in Cbl result in hyperactivation of the Egfr pathway.

              (Pai et al., 2000)

              The predicted protein lacks the proline rich domain and the putative leucine zipper of c-cbl.

              (Hime et al., 1997)

              Cbl has been cloned from a D.melanogaster embryonic cDNA library, using a human c-Cbl cDNA as a probe.

              (Hime et al., 1997)

              Cbl protein is unable to bind drk protein, although it associates with activated Egfr protein in vivo.

              (Hime et al., 1997)

              Cbl protein lacks the entire C-terminal proline-rich domain of mammalian Cbl. Cbl acts as a negative regulator of one or more receptor tyrosine kinase pathways that are essential for photoreceptor differentiation.

              (Meisner et al., 1997)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: Cbl F165

              (Pai et al., 2000)

              Source for merge of: Cbl anon-WO0118547.68

              (FlyBase, 1996-)

              Source for merge of: Cbl CG7043

              (FlyBase Genome Annotators, 2002-2003)
              Additional comments

              Annotations CG7037 and CG7043 merged as CG7037 in release 3 of the genome annotation.

              (FlyBase Genome Annotators, 2002-2003)

              Source for merge of Cbl anon-WO0118547.68 was sequence comparison ( date:051113 ).

              (FlyBase, 1996-)
              Nomenclature History
              Source for database identify of
              Nomenclature comments
              Etymology

              Named 'Cbl' after the human ortholog.

              (FlyBase, 2009-)
              Synonyms and Secondary IDs (25)
              Reported As
              Symbol Synonym
              CBL
              (Shilo, 2005)
              CG7037
              (National Institute of Genetics Fly Stocks, 2023-, Meadows, 2017.1.11, Ying et al., 2011, Perkins et al., 2009, Carrera et al., 2008, Eulalio et al., 2007, Brandt, 2006, Harris et al., 2003)
              CG7043
              Cbl
              (Almeida Machado Costa et al., 2022, Papagiannouli, 2022, Thangadurai et al., 2022, Lee et al., 2021, Zhao et al., 2020, Gervais et al., 2019, Schüpbach, 2019, Bala Tannan et al., 2018, Gene Disruption Project members, 2018-, Rojas-Ríos and Simonelig, 2018, Ashton-Beaucage and Therrien, 2017, Ketosugbo et al., 2017, Rojas-Ríos et al., 2017, Transgenic RNAi Project members, 2017-, Malartre, 2016, Sarov et al., 2016, Pradhan-Sundd and Verheyen, 2015, Wang et al., 2015, Piccirillo et al., 2014, Bergmann, 2013.10.22, Mbodj et al., 2013, Shen et al., 2013, Terriente-Felix et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Johnson et al., 2012, Du et al., 2011, Jiang et al., 2011, Wang and Pai, 2011, Ying et al., 2011, Gan et al., 2010, Janssens et al., 2010, Morozova et al., 2009, Carrera et al., 2008, Chang et al., 2008, Hossain et al., 2008, Miura et al., 2008, Wang et al., 2008, Bianco et al., 2007, Chang et al., 2007, Brandt, 2006, Burgler and Macdonald, 2005, Jekely et al., 2005, Liebl and Featherstone, 2005, Zarnescu et al., 2005, Pickeral et al., 2000)
              D-Cbl
              (Kim et al., 2017, Wang et al., 2011, Chang et al., 2007, Ranall and Beckerle, 2005, Marshall, 2000, Hime et al., 1997, Meisner et al., 1997)
              D-Cbl L
              (Chang et al., 2007)
              D-CblL
              (Wang et al., 2013)
              D-cbl
              (Kim et al., 2017, Wang et al., 2010, Wang et al., 2008, Chang et al., 2007, Nurminsky, 2007, Robertson and Hime, 2007, Robertson et al., 2007, Pai et al., 2006, Wang et al., 2005, Pai et al., 2003, Pai and Schupbach, 2002, Hime et al., 2001, Hime et al., 2001, Pai et al., 2001, Hime et al., 2000, Pai et al., 2000, Robertson et al., 2000, Hime et al., 1998, Robertson et al., 1998, Daga, 1997.1.30, Hime et al., 1997)
              D-cblL
              (Robertson and Hime, 2007, Robertson et al., 2007, Pai and Lee, 2004, Robertson et al., 2000)
              D-cblS
              (Robertson and Hime, 2007, Robertson et al., 2007, Robertson et al., 2000)
              DCbl
              (Shilo, 2003)
              Dcbl
              (Potter et al., 2000, Moghal and Sternberg, 1999)
              Dv-Cbl
              (Hime et al., 2001)
              Dv-cbl
              (Robertson and Hime, 2001, Hime et al., 1999)
              F165
              anon-WO0118547.68
              cbl
              (Bala Tannan et al., 2018, Marcogliese et al., 2017, Li et al., 2015, Dworkin et al., 2011, Pi et al., 2011, Debat et al., 2009, Epstein et al., 2009, Johnson and Cagan, 2009, Wang et al., 2008, Xu and Bergmann, 2008, Bianco et al., 2007, Wang et al., 2007, Xu and Bergmann, 2007, Dworkin and Gibson, 2006, Dworkin and Gibson., 2006, Pai et al., 2006, Seto et al., 2002, Sullivan and Rubin, 2002, Bogdan and Klämbt, 2001, Hime, 2000.5.31, Hime, 1997.12.22)
              d-cbl
              (Amiri and Stein, 2002, Callus and Mathey-Prevot, 2002)
              dCbl
              (Semaniuk et al., 2021, Truscott et al., 2014, Kannan and Fridell, 2013, Yu et al., 2012, Wong et al., 2001)
              v-Cbl
              (Sannang et al., 2012)
              Name Synonyms
              Cbl
              (Shen et al., 2013)
              Cbl proto-oncogene
              Cbl proto-oncogene ortholog
              (Malartre, 2016)
              D-cblLONG
              (Robertson et al., 2000)
              D-cblSHORT
              (Robertson et al., 2000)
              cable
              (Debat et al., 2009, Dworkin and Gibson, 2006)
              Secondary FlyBase IDs
              • FBgn0035894
              • FBgn0041253
              • FBgn0061761
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 77 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              References (154)