FlyBase Gene Report: Dmel\glo

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\glo

General Information

Symbol

Dmel\glo

Species

D. melanogaster

Name

glorund

Annotation Symbol

CG6946

Feature Type

protein_coding_gene

FlyBase ID

FBgn0259139

Gene Model Status

Stock Availability

11 publicly available

Gene Summary

glorund (glo) encodes a hnRNP F/H family RNA-binding protein that binds directly to nanos mRNA and regulates its translation during late stages of oogenesis. The functions of the product of glo include nurse cell nuclear chromatin organization, axis patterning as well as being required for viability to adulthood. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

p67-K, p67

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:11,815,206..11,819,420 [-]

Recombination map

3-51

RefSeq locus

NT_033777 REGION:11815206..11819420

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:Hrb27C; FB:FBgn0004838

(Kalifa et al., 2009)

inferred from physical interaction with FLYBASE:hfp; FB:FBgn0028577

(Kalifa et al., 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables mRNA binding

inferred from sequence or structural similarity

(Lasko, 2000)

enables nucleic acid binding

inferred from electronic annotation with InterPro:IPR035979

(InterPro Project Members, 2004-)

enables RNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000360053

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR000504

(InterPro Project Members, 2004-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in chromosome organization

inferred from mutant phenotype

(Kalifa et al., 2009)

involved_in intracellular mRNA localization involved in pattern specification process

inferred from mutant phenotype

(Kalifa et al., 2009)

involved_in maternal specification of dorsal/ventral axis, oocyte, germ-line encoded

inferred from mutant phenotype

(Kalifa et al., 2009)

involved_in pole plasm oskar mRNA localization

inferred from mutant phenotype

(Kalifa et al., 2009)

involved_in regulation of translation

inferred from mutant phenotype

(Kalifa et al., 2006)

involved_in wound healing

inferred from high throughput mutant phenotype

(Campos et al., 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of RNA splicing

inferred from biological aspect of ancestor with PANTHER:PTN000360053

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of protein-containing complex

inferred from physical interaction with FLYBASE:Hrb27C; FB:FBgn0004838

(Kalifa et al., 2009)

inferred from physical interaction with FLYBASE:hfp; FB:FBgn0028577

(Kalifa et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in nucleoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000360053

(GO Reference Genome Project, 2011-)

part_of ribonucleoprotein complex

inferred from biological aspect of ancestor with PANTHER:PTN000359854

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

glorund (glo) encodes a hnRNP F/H family RNA-binding protein that binds directly to nanos mRNA and regulates its translation during late stages of oogenesis. The functions of the product of glo include nurse cell nuclear chromatin organization, axis patterning as well as being required for viability to adulthood. [Date last reviewed: 2019-03-07]

Gene Model and Products

Number of Transcripts

4

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\glo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VGH5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Alternative translation stop created by use of multiphasic reading frames within coding region.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Gene model reviewed during 6.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0089919

2117

586

FBtr0089917

2162

586

FBtr0089918

2059

179

FBtr0481652

2198

586

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0088858

61.4

586

5.89

FBpp0088856

61.4

586

5.89

FBpp0088857

19.9

179

4.80

FBpp0428434

61.4

586

5.89

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

586 aa isoforms: glo-PA, glo-PB, glo-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\glo using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

glo_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.03

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of protein-containing complex

inferred from physical interaction with FLYBASE:Hrb27C; FB:FBgn0004838

(Kalifa et al., 2009)

inferred from physical interaction with FLYBASE:hfp; FB:FBgn0028577

(Kalifa et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\glo in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\glo

View exonic expression by tissue for Dmel\glo

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259139

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41431/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0259139

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0259139

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6946

Flygut - An atlas of the Drosophila adult midgut

FBgn0259139

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 36 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of glo

Transgenic constructs containing regulatory region of glo

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

(Ryder, 2004.4.26)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

glo^S011046

lethal - all die before end of prepupal stage | recessive

glo^S011046

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

glo^GD12082

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

glo^GD12082

viable, with Scer\GAL4^pnr-MD237

glo^GD12082

viable, with Scer\GAL4^tin.CΔ4

glo^GD12082

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

abnormal neuroanatomy | somatic clone | third instar larval stage

glo^162x

abnormal neuroanatomy | third instar larval stage

glo^162x

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4⁴⁷⁷

glo^GD12082

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

glo^GD12082

some die during prepupal stage | recessive

glo^S011046

visible, with Scer\GAL4^pnr-MD237

glo^GD12082

visible | egg stage | germline clone

glo^162x

Phenotype manifest in

Allele

chromatin & nurse cell | germ-line clone

glo^162x

dorsal appendage | germline clone

glo^162x

egg chamber | germline clone

glo^162x

larval multidendritic class IV neuron | somatic clone | third instar larval stage

glo^162x

larval multidendritic class IV neuron | third instar larval stage

glo^162x

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4⁴⁷⁷

glo^GD12082

mesonotum, with Scer\GAL4^pnr-MD237

glo^GD12082

oocyte | germline clone

glo^162x

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (13)

11 of 14

Yes

Yes

10 of 14

No

Yes

10 of 14

No

Yes

2

9 of 14

No

Yes

8 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (11)

11 of 14

Yes

Yes

10 of 14

No

Yes

10 of 14

No

Yes

9 of 14

No

Yes

8 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

Rnor\LOC120102832

1 of 14

No

No

Mus musculus (laboratory mouse) (10)

11 of 14

Yes

Yes

10 of 14

No

Yes

9 of 14

No

Yes

9 of 14

No

Yes

7 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

Xenopus tropicalis (Western clawed frog) (13)

8 of 13

Yes

Yes

8 of 13

Yes

Yes

7 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Danio rerio (Zebrafish) (10)

10 of 14

Yes

Yes

10 of 14

Yes

Yes

10 of 14

Yes

Yes

10 of 14

Yes

Yes

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

Caenorhabditis elegans (Nematode, roundworm) (4)

8 of 14

Yes

Yes

6 of 14

No

Yes

2 of 14

No

No

1 of 14

No

No

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP002892

9 of 12

Yes

Yes

Agam\AgaP_AGAP011722

3 of 12

No

No

Agam\AgaP_AGAP001930

1 of 12

No

No

Agam\AgaP_AGAP002959

1 of 12

No

No

Agam\AgaP_AGAP005249

1 of 12

No

No

Agam\AgaP_AGAP007221

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (8)

9 of 13

Yes

Yes

6 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Saccharomyces cerevisiae (Brewer's yeast) (1)

1 of 13

Yes

No

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPAC17H9.04c

1 of 12

Yes

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:glo. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

6 of 13

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

HNRNPH2; heterogeneous nuclear ribonucleoprotein H2

model of syndromic X-linked intellectual developmental disorder bain type

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

exacerbates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Malik et al., 2021)

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{R521C.UAS.Tag:HA}

(Kankel et al., 2020)

exacerbates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^{M337V.UAS.Tag:MYC}

(Kankel et al., 2020)

ameliorates neurodegenerative disease

modeled by TBPH^UAS.Tag:FLAG

(Appocher et al., 2017)

ameliorates neurodegenerative disease

modeled by TBPH^UAS.Tag:FLAG

(Appocher et al., 2017)

exacerbates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^50.UAS.EGFP

(Lee et al., 2016)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HNRNPF; heterogeneous nuclear ribonucleoprotein F

11 of 14

HNRNPH1; heterogeneous nuclear ribonucleoprotein H1

10 of 14

NEURODEVELOPMENTAL DISORDER WITH CRANIOFACIAL DYSMORPHISM AND SKELETAL DEFECTS; NEDCDS

HNRNPH2; heterogeneous nuclear ribonucleoprotein H2

10 of 14

INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, BAIN TYPE; MRXSB

syndromic X-linked intellectual developmental disorder bain type

HNRNPH3; heterogeneous nuclear ribonucleoprotein H3

9 of 14

GRSF1; G-rich RNA sequence binding factor 1

8 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

(Hu et al., 2017.6.13)

anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot

(Bansal et al., 2020)

(Hu et al., 2017.6.13)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

anti tag coimmunoprecipitation, anti tag western blot, western blot, Identification by mass spectrometry, molecular sieving, molecular weight estimation by staining, pull down

(Peng and Gavis, 2022, Bansal et al., 2020)

pull down, Identification by mass spectrometry

(Fajner et al., 2021)

anti tag coimmunoprecipitation, western blot, pull down, anti bait coimmunoprecipitation

(Tamayo et al., 2017, Kalifa et al., 2009)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry

(Bansal et al., 2020)

anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry

(Bansal et al., 2020)

anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry

(Bansal et al., 2020)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

pull down, western blot, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation

(Tamayo et al., 2017, Kalifa et al., 2009)

anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry

(Bansal et al., 2020)

anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot

(Bansal et al., 2020)

RNA-protein

Physical Interaction

Assay

References

anti bait coimmunoprecipitation, primer specific pcr

(Gehrke et al., 2015)

anti tag coimmunoprecipitation, reverse transcription pcr

(Peng and Gavis, 2022)

nuclear magnetic resonance, anti tag coimmunoprecipitation, reverse transcription pcr, quantitative reverse transcription pcr, electrophoretic mobility shift assay, autoradiography

(Warden et al., 2023, Tamayo et al., 2017, Andrews et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Kalifa et al., 2009)

enhanceable

(Appocher et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Gehrke et al., 2015)

suppressible

(Appocher et al., 2017)

enhanceable

(Appocher et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66551

DroID - A comprehensive database of gene and protein interactions.

FBgn0259139

MIST (protein-protein) - An integrated Molecular Interaction Database

41431

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-51

Cytogenetic map

Sequence location

3R:11,815,206..11,819,420 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

86F8-86F9

Limits computationally determined from genome sequence between P{EP}Lk6^EP886 and P{PZ}svp⁰⁷⁸⁴²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

86F-86F

(determined by in situ hybridisation)

(Szeged Stock Center, 1998-, Deak et al., 1997)

Experimentally Determined Recombination Data

Location

3-51

(FlyBase, 2016)

3-48.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

18576

w¹¹¹⁸; PBac{WH}glo^f02674/TM6B, Tb¹

21843

y¹ w^67c23; P{Mae-UAS.6.11}glo^DP01368

57693

y¹ w^*; P{neoFRT}82B glo^162x/TM3, Sb¹

84042

y¹ sc^* v¹ sev²¹; P{TKO.GS04452}attP40

33668

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00079}attP2

36066

y¹ sc^* v¹ sev²¹; P{TRiP.GL00438}attP40

99969

y¹ w^*; TI{CRIMIC.TG4.1}glo^{CR70581-TG4.1}/TM3, Sb¹ Ser¹

6946R-2

v110653

P{KK108457}VIE-260B

v27752

w¹¹¹⁸; P{GD12082}v27752

v318719

PBac{fTRG01009.sfGFP-TVPTBF}VK00002

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (86)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0259139

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0259139

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

anti-Glorund_5B7

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.

(Hansen et al., 2009)

glo interacts with the region of the nos translational control element (TCE) responsible for translational repression during oogenesis.

(Kalifa et al., 2006)

glo is required for repression of unlocalised nos mRNA in late oocytes.

(Kalifa et al., 2006)

Identification: binds nos TCE.

(Kalifa et al., 2004)

Area matching Drosophila EST AA263590. This EST has sequence similarity to human hRNP F.

(Davies, 2001.3.15)

Relationship to Other Genes

Source for database merge of

Source for merge of: glo p67-K

(Kalifa et al., 2006)

Source for merge of: CG6946 anon-WO0118547.328

(FlyBase, 1996-)

Additional comments

Source for merge of CG6946 anon-WO0118547.328 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: glo CG6946

(Kalifa and Gavis, 2006.2.28)

Nomenclature comments

Etymology

"glorund" (glo) is so named, after the evil dragon from J.R.R. Tolkien's 'The Silmarillion', who appeared before Smaug (smg).

(Kalifa et al., 2006)

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

110/46

(Deak et al., 1997)

CG6946

(Appocher et al., 2017, Kolkhof et al., 2017, Brooks et al., 2015, Horan et al., 2015, Hosono et al., 2015, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Hansen et al., 2009, Keleman et al., 2009.8.5, Kalifa et al., 2006, Muller et al., 2005, Giot et al., 2003, Das, 2002.7.3, Caggese, 2000.5.11, Deak, 1999.12.22)

Glo

(Choudhury et al., 2024, Warden et al., 2023, Layalle et al., 2021, Malik et al., 2021, Bansal et al., 2020, Ustaoglu et al., 2019, Appocher et al., 2017, Hosamani et al., 2016, Tan et al., 2016, Gehrke et al., 2015, Andrews et al., 2011, Kalifa and Gavis, 2007, Kalifa et al., 2006)

anon-WO0118547.328

cg6946

(Lasko, 2000)

l(3)S011046

(Szeged Stock Center, 1998-)

l(3)S11046

(Kusano et al., 2001)

p67

(Kalifa et al., 2006, Kalifa et al., 2004)

p67-K

Name Synonyms

Glorund

(Gehrke et al., 2015, Brechbiel and Gavis, 2008, Andrews and Gavis, 2007, Jain and Gavis, 2007, Kalifa and Gavis, 2007)

glorund

(Hansen et al., 2009, Kalifa et al., 2009, Andrews, 2006, Kalifa and Gavis, 2006.2.28, Kalifa et al., 2006, Kalifa et al., 2006)

p67-K

Secondary FlyBase IDs

FBgn0037954
FBgn0062090
FBgn0069092

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41431

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VGH5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VGH5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259139

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41431/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0259139

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0259139

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6946

MARRVEL_MODEL - MARRVEL (model organism gene)

41431

PDB - An information portal to biological macromolecular structures

Linkouts

BioGRID - A database of protein and genetic interactions.

66551

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0259139

DroID - A comprehensive database of gene and protein interactions.

FBgn0259139

DRSC - Results frm RNAi screens

FBgn0259139

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

anti-Glorund_5B7

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

glo_1

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0259139

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6946

Flygut - An atlas of the Drosophila adult midgut

FBgn0259139

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0259139

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004364

MIST (protein-protein) - An integrated Molecular Interaction Database

41431

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (110)