FlyBase Gene Report: Dmel\Np

General Information

Symbol

Dmel\Np

Species

D. melanogaster

Name

Notopleural

Annotation Symbol

CG34350

Feature Type

protein_coding_gene

FlyBase ID

FBgn0265011

Gene Model Status

Current

Stock Availability

11 publicly available

Enzyme Name (EC)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

45A1-45A1

Sequence location

2R:8,992,945..9,006,587 [-]

Recombination map

2-60

RefSeq locus

NT_033778 REGION:8992945..9006587

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables serine hydrolase activity

inferred from high throughput direct assay

(Kumar et al., 2021)

enables serine-type peptidase activity

inferred from mutant phenotype

(Drees et al., 2019)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables serine-type endopeptidase activity

inferred from sequence model

(Cao and Jiang, 2018, Ross et al., 2003)

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

enables serine-type peptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN002543071

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in liquid clearance, open tracheal system

inferred from mutant phenotype

(Drees et al., 2019)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in protein processing

inferred from biological aspect of ancestor with PANTHER:PTN002543071

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from sequence model

(Ross et al., 2003)

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in apical plasma membrane

inferred from direct assay

(Drees et al., 2019)

located_in extracellular space

inferred from direct assay

(Drees et al., 2019)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001956710

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

S1A SERINE PROTEASES - TRYPSIN-LIKE

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

serine-type endopeptidase activity

Summaries

Gene Group (FlyBase)

S1A SERINE PROTEASES - TRYPSIN-LIKE -: Trypsin-like serine proteases of the S1A family are endopeptidases that cleave amide substrates following Arginine or Lysine at the P1 position. (Adapted from FBrf0239469).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

*Np: Notopleural

Np: Notopleural

From Bridges, Skoog, and Li, 1936, Genetics 21: 788-95.

Notopleural, humeral, presutural, and pretarsal bristles shorter and blunter than normal. Wings short and broad. Female produces few or no progeny. Viability fair. Development retarded. More extreme at 19 than at 25, also more extreme in female. Lethal over T(2;3)dp. Homozygous lethal. RK2A.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Np for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A1Z7M3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Np-RA

FBtr0112560

NM_136593

4096

1041

Np-RB

FBtr0307883

NM_001259284

3822

1041

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Np-PA

FBpp0111472

111.2

1041

9.45

FBpp0300317

111.2

1041

9.45

A1Z7M3

NP_001246213

AFH07968

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1041 aa isoforms: Np-PA, Np-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

A1Z7M3

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Np using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Np_1
Np_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.47

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11

tracheal primordium

(Drees et al., 2019)

embryonic stage 11 -- 16

embryonic/larval tracheal section

(Drees et al., 2019)

embryonic stage 13 -- 16

embryonic anal pad

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval posterior spiracle

(Drees et al., 2019, Fisher et al., 2012)

embryonic/larval foregut

(Drees et al., 2019)

embryonic/larval pharynx

(Drees et al., 2019)

embryonic/larval hindgut

(Drees et al., 2019)

embryonic/larval salivary gland

(Drees et al., 2019)

embryonic stage 13 -- 17

embryonic/larval epidermis

(Drees et al., 2019)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical plasma membrane

inferred from direct assay

(Drees et al., 2019)

located_in extracellular space

inferred from direct assay

(Drees et al., 2019)

Expression Deduced from Reporters

Reporter: TI{TI}Np^EGFP

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11

tracheal primordium

(Drees et al., 2019)

embryonic stage 11 -- 16

embryonic/larval tracheal section

(Drees et al., 2019)

embryonic stage 13 -- 16

embryonic/larval foregut

(Drees et al., 2019)

embryonic/larval pharynx

(Drees et al., 2019)

embryonic/larval hindgut

(Drees et al., 2019)

embryonic/larval posterior spiracle

(Drees et al., 2019)

embryonic/larval salivary gland

(Drees et al., 2019)

embryonic stage 13 -- 17

embryonic/larval epidermis

(Drees et al., 2019)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Np in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Np

View exonic expression by tissue for Dmel\Np

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265011

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35904/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265011

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085379

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265011

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 48 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Np

Transgenic constructs containing regulatory region of Np

Aberrations (Deficiencies and Duplications) ( 21 )

Inferred from experimentation ( 21 )

Gene disrupted in

Df(2R)BSC271

(Drees et al., 2019, Kahsai and Cook, 2018)

Df(2R)Exel8048

(Ryder, 2004.4.26)

Df(2R)Np1

(Konev et al., 1994)

Df(2R)Np3

(Mohr and Boswell, 2002)

Df(2R)Np4

(Konev et al., 1994)

Df(2R)Np5

(Mohr and Boswell, 2002, Konev et al., 1994)

Df(2R)Np

(Bridges et al., 1936)

Gene partially disrupted in

Df(2R)w45-30n

(Mohr and Boswell, 2002)

Gene duplicated in

Dp(2;Y)G6-1

(Konev et al., 1994)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Np^S2

lethal, with Scer\GAL4^pnr-MD237

Np^GD13443

lethal (with Df(2R)BSC270)

Np^{MI10279-TG4.1}

lethal (with Df(2R)BSC271)

lethal | recessive

lethal - all die before end of larval stage | recessive

Np^W

lethal - all die during embryonic stage

lethal - all die during embryonic stage (with Df(2R)BSC271)

lethal - all die during embryonic stage (with Np^C2)

Np^P6

lethal - all die during embryonic stage (with Np^P6)

Np^C2

lethal - all die during embryonic stage | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Np^GD13443

viable, with Scer\GAL4^Mef2.PR

Np^GD13443

viable, with Scer\GAL4^pnr-MD237

Np^GD13828

Sterility

Allele

female sterile | dominant

Np¹

Other Phenotypes

Allele

abnormal developmental rate | dominant

Np¹

some die during embryonic stage

some die during embryonic stage | recessive

some die during larval stage | recessive

Np^W

visible | dominant

Np¹

visible | embryonic stage 17 (with Np^C2)

Np^P6

visible | embryonic stage 17 (with Np^P6)

Np^C2

Phenotype manifest in

Allele

adult thorax & microchaeta

Np¹

apical plasma membrane | embryonic stage

Np^P6

apical plasma membrane | embryonic stage (with Np^C2)

Np^P6

apical plasma membrane | embryonic stage (with Np^P6)

Np^C2

chitin-based extracellular matrix | embryonic stage

Np^P6

chitin-based extracellular matrix | embryonic stage (with Np^C2)

Np^P6

chitin-based extracellular matrix | embryonic stage (with Np^P6)

Np^C2

embryonic/larval dorsal tracheal branch | embryonic stage, with Scer\GAL4^btl.PU

Np^UAS.cDa

embryonic/larval salivary gland | embryonic stage

Np^C2

embryonic/larval tracheal dorsal trunk | embryonic stage

Np^P6

embryonic/larval tracheal dorsal trunk | embryonic stage (with Np^C2)

Np^P6

embryonic/larval tracheal dorsal trunk | embryonic stage (with Np^P6)

Np^C2

embryonic/larval tracheal section | embryonic stage 17

embryonic/larval tracheal section | embryonic stage 17, with Scer\GAL4^btl.PS

Np^GD13443

embryonic/larval tracheal section | embryonic stage 17 (with Df(2R)BSC271)

embryonic/larval tracheal section | embryonic stage 17 (with Np^C2)

Np^P6

embryonic/larval tracheal section | embryonic stage 17 (with Np^P6)

Np^C2

embryonic/larval tracheal section | embryonic stage, with Scer\GAL4^btl.PU

Np^UAS.cDa

humeral bristle

Np¹

larval tracheocyte | embryonic stage

Np^P6

larval tracheocyte | embryonic stage (with Np^C2)

Np^P6

larval tracheocyte | embryonic stage (with Np^P6)

Np^C2

macrochaeta

Np¹

notopleural bristle

Np¹

posterior crossvein

Np¹

taenidial fold | embryonic stage 17 (with Np^C2)

Np^P6

taenidial fold | embryonic stage 17 (with Np^P6)

Np^C2

tracheal lumen | embryonic stage

Np^P6

ventral denticle belt | embryonic stage 17 (with Np^C2)

Np^P6

ventral denticle belt | embryonic stage 17 (with Np^P6)

Np^C2

wing

Np¹

wing vein

Np¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (108)

Hsap\ST14

5 of 14

Yes

Hsap\PRSS21

4 of 14

Hsap\CTRB1

3 of 14

Hsap\CTRB2

3 of 14

Yes

Hsap\CTRL

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Hsap\TPSAB1

3 of 14

Yes

Hsap\TPSB2

3 of 14

Yes

Hsap\TPSD1

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\HPN

2 of 14

Hsap\KLKB1

2 of 14

Hsap\MST1

2 of 14

Yes

Hsap\MST1L

2 of 14

Yes

Hsap\OVCH1

2 of 14

Hsap\OVCH2

2 of 14

Hsap\PLG

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CMA1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\HABP2

1 of 14

Hsap\HGFAC

1 of 14

Hsap\HP

1 of 14

Yes

Hsap\HPR

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (83)

Rnor\St14

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Rnor\Tmprss9

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Rnor\C1r

1 of 14

Yes

Rnor\C1s

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Hpn

1 of 14

Rnor\Hp

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Masp2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (98)

Mmus\Tmprss2

5 of 14

Yes

Mmus\Klkb1

4 of 14

Mmus\Tmprss3

4 of 14

Mmus\Tmprss6

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Plg

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Mmus\C1rb

1 of 14

Yes

Mmus\C1rl

1 of 14

Yes

Mmus\C1s1

1 of 14

Yes

Mmus\C1s2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Hp

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Masp2

1 of 14

Mmus\Mst1

1 of 14

Mmus\Pamr1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (99)

Xtro\LOC108648818

4 of 13

Yes

Xtro\LOC548809

3 of 13

Xtro\LOC595077

3 of 13

Yes

Xtro\LOC101731336

3 of 13

Yes

Xtro\pafah1b3

3 of 13

Xtro\prss8

3 of 13

Yes

Xtro\prss27

3 of 13

Xtro\prss29

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Xtro\prss8l.5 loc108703873

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\cela3a

1 of 13

Yes

Xtro\corin

1 of 13

Xtro\ctrc

1 of 13

Yes

Xtro\ctsg

1 of 13

Xtro\efcab7

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100485189

1 of 13

Xtro\LOC100487305

1 of 13

Yes

Xtro\LOC100490440

1 of 13

Xtro\LOC100490933

1 of 13

Xtro\LOC100497024

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC116412071

1 of 13

Yes

Xtro\LOC116412122

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (86)

Drer\LOC100331291

6 of 14

Yes

Drer\st14a

4 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\ctrl

2 of 14

Drer\ela2l

2 of 14

Drer\hgfa

2 of 14

Yes

Drer\hgfb

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Drer\cela1.5

1 of 14

Drer\cfd

1 of 14

Drer\cfi

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:dkey-21e2.14

1 of 14

Drer\si:dkey-33m11.7

1 of 14

Drer\si:dkey-238d18.3

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\try-1

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (283)

Agam\AgaP_AGAP008996

9 of 12

Yes

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP004638

1 of 12

Yes

Agam\AgaP_AGAP004639

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

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1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

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1 of 12

1 of 12

1 of 12

1 of 12

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1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP011430

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Np. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (224)

CG8172

7 of 13

flz

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

tpr

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

MP1

2 of 13

snk

2 of 13

Sp7

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

1 of 13

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1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

mas

1 of 13

Phae1

1 of 13

Phae2

1 of 13

psh

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

SPE

1 of 13

SPH93

1 of 13

spirit

1 of 13

teq

1 of 13

θTry

1 of 13

tld

1 of 13

tok

1 of 13

ζTry

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ST14; ST14 transmembrane serine protease matriptase

model of autosomal recessive congenital ichthyosis 11

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ST14; ST14 transmembrane serine protease matriptase

5 of 14

606797

ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 11; ARCI11

autosomal recessive congenital ichthyosis 11

PRSS21; serine protease 21

4 of 14

608159

CTRB1; chymotrypsinogen B1

3 of 14

118890

CTRB2; chymotrypsinogen B2

3 of 14

619620

CTRL; chymotrypsin like

3 of 14

118888

PRSS27; serine protease 27

3 of 14

608018

PRSS33; serine protease 33

3 of 14

613797

PRSS56; serine protease 56

3 of 14

613858

MICROPHTHALMIA, ISOLATED 6; MCOP6

isolated microphthalmia 6

TMPRSS2; transmembrane serine protease 2

3 of 14

602060

TMPRSS6; transmembrane serine protease 6

3 of 14

609862

IRON-REFRACTORY IRON DEFICIENCY ANEMIA; IRIDA

microcytic anemia

TMPRSS13; transmembrane serine protease 13

3 of 14

610050

TPSAB1; tryptase alpha/beta 1

3 of 14

191080

TPSB2; tryptase beta 2

3 of 14

191081

TPSD1; tryptase delta 1

3 of 14

609272

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

Hsap\ST14

(Drees et al., 2019)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

enzymatic study, western blot

(Drees et al., 2019)

Np - pio

enzymatic study, western blot

(Drees et al., 2019)

Np - tpr

enzymatic study, western blot

(Drees et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0265011

MIST (protein-protein) - An integrated Molecular Interaction Database

35904

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Regulation of Complement cascade

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-60

Cytogenetic map

45A1-45A1

Sequence location

2R:8,992,945..9,006,587 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

45A1-45A1

Limits computationally determined from genome sequence between P{lacW}babo^k16912 and P{lacW}l(2)k16529^k16529

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-60

(FlyBase, 2016)

2-58.0

(Comeron et al., 2012)

2-58.7--60.2

(Bridges et al., 1936)

Left of (cM)

(Bridges et al., 1936)

Right of (cM)

(Bridges et al., 1936)

Notes

Inseparable from blo by recombination.

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

5493

Np²/CyO

64043

y¹ v¹; P{TRiP.HMJ23464}attP40/CyO

30675

y¹ w^*; Mi{MIC}Np^MI00240/CyO

53836

y¹ w^*; Mi{MIC}Np^MI10279/SM6a

67490

y¹ w^*; Mi{Trojan-GAL4.1}Np^{MI10279-TG4.1}/SM6a

64500

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05518}attP40

Kyoto

101402

CyO, Duox^Cy dpy^lv1 pr¹ cn² / Np^m

101988

CyO, Duox^Cy dpy^lv1 pr¹ cn² / In(2R)Np^r, Np^r ; T(2;3)G10

NIG-Fly

HMJ23464

y¹ v¹; P{TRiP.HMJ23464}attP40/CyO

VDRC

v105297

P{KK109020}VIE-260B

v23381

w¹¹¹⁸; P{GD13443}v23381/TM3

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Haploinsufficient locus (not associated with strong haplolethality or haplosterility).

(Cook et al., 2012)

Np alleles show complex complementation patterns both inter se and with respect to aberrations Df(2R)Np5 and Df(2R)w45-30n.

(Mohr and Boswell, 2002)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG11824 CG8181

(FlyBase Genome Annotators, 2007)

Source for merge of: Np CG34350

(Cook et al., 2012)

Additional comments

Annotations CG11824 and CG8181 merged as CG34350 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG11824

(Shah et al., 2008, Stanyon et al., 2004)

CG34350

(Drees et al., 2019, Hosono et al., 2015, Cook et al., 2012, Cook et al., 2010.2.12, Wasbrough et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, FlyBase Genome Annotators, 2007)

CG8181

(Göpfert et al., 2025, Woodward et al., 2025, Drees et al., 2023, Tsuboi et al., 2023, Kumar et al., 2021, Li et al., 2021, Diaz-de-la-Loza et al., 2020, Li Zheng et al., 2020, Drees et al., 2019, Cao and Jiang, 2018, Lee et al., 2018, Gene Disruption Project members, 2016-, Cook et al., 2012)

SP59

(Ross et al., 2003)

cSP59

(Cao and Jiang, 2018)

(Corbett-Detig et al., 2013)

Name Synonyms

CG11824

CG8181

Notopleural

notopleural

(Corbett-Detig et al., 2013)

Secondary FlyBase IDs

FBgn0002963
FBgn0085379
FBgn0033360
FBgn0033361

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 29 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35904

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A1Z7M3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A1Z7M3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A1Z7M3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265011

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35904/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265011

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265011

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34350

MARRVEL_MODEL - MARRVEL (model organism gene)

35904

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0265011

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Np_1
Np_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085379

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0265011

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033855

MIST (protein-protein) - An integrated Molecular Interaction Database

35904

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Regulation of Complement cascade

References (57)

The following external sites may use different assemblies or annotations than FlyBase.

-0.47

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