FB2026_02 , released June 18, 2026
Gene: Dmel\RanGAP
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General Information
Symbol
Dmel\RanGAP
Species
D. melanogaster
Name
Ran GTPase activating protein
Annotation Symbol
CG9999
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003346
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion (PubMed:10073941). Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction (PubMed:10073941). During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769). (UniProt, Q9VIW3)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Sd, Segregation distorter, Sd-RanGAP

Key Links
Genomic Location
Cytogenetic map
37E1-37E1
Sequence location
Recombination map
2-54
RefSeq locus
NT_033779 REGION:19441959..19447317
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables GTPase activator activity
inferred from direct assay
(Kusano et al., 2001)
enables RNA binding
inferred from direct assay
(Zhang et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTPase activator activity
inferred from electronic annotation with InterPro:IPR027038, InterPro:IPR036720
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN001536945
(GO Reference Genome Project, 2011-)
enables small GTPase binding
inferred from biological aspect of ancestor with PANTHER:PTN001536945
(GO Reference Genome Project, 2011-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in nucleocytoplasmic transport
inferred from mutant phenotype
(Kusano et al., 2001)
involved_in protein export from nucleus
inferred from mutant phenotype
(Kusano et al., 2001)
involved_in regulation of nucleocytoplasmic transport
inferred from mutant phenotype
(Wu et al., 2019)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in meiotic chromosome segregation
traceable author statement
(Kusano et al., 2003)
involved_in nuclear export
inferred from biological aspect of ancestor with PANTHER:PTN001536945
(GO Reference Genome Project, 2011-)
involved_in nucleocytoplasmic transport
non-traceable author statement
(Kusano et al., 2003)
involved_in signal transduction
inferred from electronic annotation with InterPro:IPR036720
(InterPro Project Members, 2004-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Wu et al., 2019)
inferred from direct assay
(Xylourgidis et al., 2006)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Zhang et al., 2015, Kusano et al., 2001)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN001536945
(GO Reference Genome Project, 2011-)
located_in nuclear membrane
inferred from experiment
(Hampoelz et al., 2019, Xylourgidis et al., 2006)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001536945
(GO Reference Genome Project, 2011-)
is_active_in perinuclear region of cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN001536945
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the RNA1 family. (Q9VIW3)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RAN GTPASE ACTIVATING PROTEINS -
RanGAP promotes conversion of Ran-GTP to Ran-GDP on cytosolic side of the nuclear pore as part of the nucleocytoplasmic transport shuttling cycle of Ran. (Adapted from PMID:15731001).
Protein Function (UniProtKB)
GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion (PubMed:10073941). Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction (PubMed:10073941). During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769).
(UniProt, Q9VIW3)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Sd: Segregation distorter
Sd-bearing second chromosomes are referred to as SD; they carry, in addition to Sd, other components of the segregation distortion system; they may carry inversions and recessive lethal alleles as well. The constitutions of various SD chromosomes are tabulated below. Other components of the segregation distortion system are E(SD) (Enhancer of SD) at the base of 2L; and Rsp (Responder) at the base of 2R; St(SD) (Stabilizer of SD) located more distally in 2R appears to comprise several weak enhancers of distortion (Miklos, 1972, Genetics 70: 405-18). All naturally occurring SD chromosomes carry Sd and E(SD) but lack Rsp [sometimes said to carry Rspi (Responder insensitive)]; most normal chromosomes carry a Rsp element. SD/+ males transmit SD-bearing, to the virtual exclusion of +-bearing, homologues; as many as 99% of the functional sperm may carry SD (defined as k = .99). The sex ratio of the minority class of offspring, in diverse crosses, is skewed in proportion to k in such a way as to indicate that within this class the probability of recovery of XY- < X - < Y -bearing <nullo-X, nullo-Y sperm (Denell, Judd, and Richardson, 1969, Genetics 61: 129-39; Denell and Miklos, 1971, Mol. Gen. Genet. 110: 167-77). Distortion by Sd requires heterozygosity at the Rsp locus; when Rsp is on the homologue, the Sd-bearing chromosome is preferentially recovered. and when Rsp and Sd are in coupling, the homologue is recovered preferentially. Extensive electron microscopic studies of spermatogenesis (Tokuyasu, Peacock, and Hardy, 1972, Z. Zellforsch. 124: 479-506; 127: 492-525; 1977, J. Ultrastruct. Res. 48: 284-303) demonstrate that spermiogenesis of SD/+ males is defective; chromatin in half of the spermatid nuclei fails to condense properly, leading in some cases to a failure of the spermatids to become individually invested in membrane, remaining syncytial instead, and in all cases to incomplete maturation of half the sperm. In addition, the transition from lysine-rich to sperm-specific arginine-rich histone, which normally occurs in late spermiogenesis, does not appear to take place in half the spermatids of SD/+ males (Hauschteck-Jungen and Hartl, 1978, Genetics 101: 57-69). Temperature-sensitive period of distortion said to be in the primary spermatocyte (Mange, 1968, Genetics 58: 399-413); however, see Matthews and Mortin (1983, Canad. J. Genet. Cytol. 25: 662-67). k values also reported to increase with time of storage of sperm by females (Hartl, 1973, Genetics 74: 619-31), to decrease with the age of SD/+ males (Hiraizumi and Watanabe, 1969, Genetics 63: 212-31), and to be influenced by the genotype of the female to which such males are crossed (Denell and Judd, 1969, Mol. Gen. Genet. 105: 262-74). Segregation distortion is subject to modification by numerous genetic factors throughout the genome; in addition various abnormal chromosome constitutions have been reported to reduce k values (Novitski and Erlich, 1970, DIS 45: 102; Enns, 1970, DIS 45: 136; Fowler, 1971, DIS 46: 74). Homozygous (when viable) and heteroallelic constitutions exhibit variably reduced male fertility, but the contribution of Sd vis a vis other components of the SD chromosomes involved not easily ascertainable. SD chromosomes without effect in females.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\RanGAP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VIW3)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
RanGAP-RA
FBtr0081234
NM_057364
2401
596
RanGAP-RB
FBtr0334174
NM_001273649
2008
596
RanGAP-RC
FBtr0334175
NM_001273650
2144
588
Additional Transcript Data and Comments
Reported size (kB)

2.0 (northern blot)

(Powers and Ganetzky, 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
RanGAP-PA
FBpp0080775
66.1
596
4.29
Q9VIW3
NP_476712
AAF53801
RanGAP-PB
FBpp0306291
66.1
596
4.29
Q9VIW3
NP_001260578
AGB93113
RanGAP-PC
FBpp0306292
65.2
588
4.29
M9PD65
NP_001260579
AGB93114
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

596 aa isoforms: RanGAP-PA, RanGAP-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

596 (aa); 66 (kD observed)

(Merrill et al., 1999)

363 (aa)

(Powers and Ganetzky, 1991)
Comments
External Data
Subunit Structure (UniProtKB)

Forms a complex with Nup358/RanBP2, sbr/Nxf1 and Nxt1 (PubMed:14729961). Associates with the nuclear pore complex via its interaction with Nup358/RanBP2 (PubMed:14729961, PubMed:17032737).

(UniProt, Q9VIW3)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RanGAP using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.66

Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
(Powers and Ganetzky, 1991)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
foregut anlage in statu nascendi
(Fisher et al., 2012)
hindgut anlage in statu nascendi
(Fisher et al., 2012)
mesectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
anterior endoderm anlage
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
foregut anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
mesectoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
mesectoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
larval lateral VNC glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
proventriculus primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic central brain surface glial cell
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 17
germline cell
(Casper and Van Doren, 2009)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
pupal stage
(Powers and Ganetzky, 1991)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Trieselmann and Wilde, 2002)
larval stage
embryonic/larval salivary gland
(Kusano et al., 2001)
third instar larval stage
type I neuroblast
(Wu et al., 2019)
type II neuroblast
(Wu et al., 2019)
adult stage
testis
(Kusano et al., 2001)
adult stage | female
oocyte
(Cesario and McKim, 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
testis
(Merrill et al., 1999)
Additional Descriptive Data

RanGAP is widely detected in neuroblasts and other cells in the central brain and optic lobes in third istar larvae. It is found in both type I and type II neuroblasts. Expression becomes more restricted in the pupal brain. It is found in the cytoplasm and or in a nuclear-membrane-bound SUMOylated form.

(Wu et al., 2019)

Rcc1 protein localizes around the outside of the karyosome in the oocyte.

(Cesario and McKim, 2011)

The protein is localized to the cytoplamic side of the nuclear membrane in both adult testis cells and larval salivary gland cells.

(Kusano et al., 2001)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Wu et al., 2019)
inferred from direct assay
(Xylourgidis et al., 2006)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Zhang et al., 2015, Kusano et al., 2001)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RanGAP in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of RanGAP
Transgenic constructs containing regulatory region of RanGAP
Aberrations (Deficiencies and Duplications) ( 38 )
Inferred from experimentation ( 38 )
Gene partially duplicated in
Dp(2;2)RanGAPSd
(Merrill et al., 1999)
Gene disrupted in
Df(2L)E55
(Brittnacher and Ganetzky, 1983)
Df(2L)Exel7075
(Ryder, 2004.4.26)
Df(2L)Exel7076
(Ryder, 2004.4.26)
Df(2L)Exel8041
(Ryder, 2004.4.26)
Df(2L)pr-A8
(Ganetzky, 1977)
Df(2L)pr-A14
(Ganetzky, 1977)
Df(2L)pr-A16
(Ganetzky, 1977)
Df(2L)Sd2
(Temin, 1991, Brittnacher and Ganetzky, 1984, Brittnacher and Ganetzky, 1983)
Df(2L)Sd14
(Powers and Ganetzky, 1991, Temin, 1991, Brittnacher and Ganetzky, 1984, Brittnacher and Ganetzky, 1983)
Df(2L)Sd37
(McLean et al., 1994, Temin, 1991, Brittnacher and Ganetzky, 1984, Brittnacher and Ganetzky, 1983, Ganetzky, 1977)
Df(2L)Sd57
(Temin, 1991, Brittnacher and Ganetzky, 1984, Brittnacher and Ganetzky, 1983)
Df(2L)Sd68
(Temin, 1991, Brittnacher and Ganetzky, 1983)
Df(2L)Sd77
(McLean et al., 1994, Temin, 1991, Brittnacher and Ganetzky, 1984, Brittnacher and Ganetzky, 1983)
Df(2L)Sd-Rev8a-4
(McLean, 2016.1.20)
Df(2L)TW158
(Palopoli and Wu, 1996)
Df(2L)VA6
(Brittnacher and Ganetzky, 1983)
Df(2L)VA8
(Brittnacher and Ganetzky, 1983)
Dp(2;Y)R10
(Temin, 1991)
Gene not disrupted in
Df(2L)E71
(Brittnacher and Ganetzky, 1983, Ganetzky, 1977)
Df(2L)hk18
(Brittnacher and Ganetzky, 1983)
Df(2L)hk39
(Brittnacher and Ganetzky, 1983)
Df(2L)pr21
(Brittnacher and Ganetzky, 1983)
Df(2L)pr26
(Brittnacher and Ganetzky, 1983)
Df(2L)pr47
(Brittnacher and Ganetzky, 1983)
Df(2L)pr49
(Brittnacher and Ganetzky, 1983)
Df(2L)pr65
(Brittnacher and Ganetzky, 1983)
Df(2L)pr67
(Brittnacher and Ganetzky, 1983)
Df(2L)pr69
(Brittnacher and Ganetzky, 1983)
Df(2L)pr-B12
(Brittnacher and Ganetzky, 1983)
Df(2L)TW2
(Brittnacher and Ganetzky, 1983)
Df(2L)TW130
(Brittnacher and Ganetzky, 1983)
Df(2L)VA14
(Brittnacher and Ganetzky, 1983)
Df(2L)VA16
(Brittnacher and Ganetzky, 1983)
Gene duplicated in
Dp(2;Y)c53
(Temin, 1991, Golic, 1990)
Dp(2;Y)G
(Lyttle, 1986)
Dp(2;Y)SD
(Temin, 1991)
Gene partially disrupted in
Df(2L)CRIMIC-CR70635
(Gene Disruption Project members, 2018-)
Inferred from location ( 15 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4insc-Mz1407
lethal - all die before end of second instar larval stage
lethal - all die during pupal stage | female
lethal - all die during pupal stage | female (with RanGAP327)
lethal - all die during pupal stage | female (with RanGAPEP1173)
lethal - all die during pupal stage | male (with RanGAP327)
lethal - all die during pupal stage | male (with RanGAPEP1173)
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die | male
partially lethal - majority live | maternal effect
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal meiotic cell cycle
abnormal meiotic cell cycle | dominant
abnormal neuroanatomy | female limited | progressive | third instar larval stage
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
abnormal neuroanatomy | prepupal stage
abnormal neuroanatomy | prepupal stage (with RanGAP327)
abnormal neuroanatomy | prepupal stage (with RanGAPEP1173)
abnormal neuroanatomy | progressive | somatic clone | third instar larval stage
abnormal neuroanatomy | progressive | third instar larval stage (with RanGAP327)
abnormal neuroanatomy | progressive | third instar larval stage (with RanGAPEP1173)
abnormal neuroanatomy | second instar larval stage
decreased cell number | female limited | progressive | third instar larval stage
decreased cell number | prepupal stage
decreased cell number | prepupal stage (with RanGAP327)
decreased cell number | prepupal stage (with RanGAPEP1173)
decreased cell number | progressive | somatic clone | third instar larval stage
decreased cell number | progressive | third instar larval stage (with RanGAP327)
decreased cell number | progressive | third instar larval stage (with RanGAPEP1173)
decreased cell number | second instar larval stage
decreased occurrence of cell division | female | third instar larval stage
some die during embryonic stage | maternal effect
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
embryonic/larval salivary gland, with Scer\GAL4fkh.PH
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
larval central brain | female | third instar larval stage
larval central brain | female limited | progressive | third instar larval stage
larval central brain | progressive | second instar larval stage | somatic clone
larval central brain | second instar larval stage
larval neuroblast | female | third instar larval stage
larval neuroblast | female limited | progressive | third instar larval stage
larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
larval neuroblast | progressive | somatic clone | third instar larval stage
larval neuroblast | second instar larval stage
mesonotum, with Scer\GAL4pnr-MD237
spermatid
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (19)
Hsap\RANGAP1
13 of 14
Yes
Yes
Hsap\LRRC34
1 of 14
No
No
Hsap\LRRC45
1 of 14
No
Yes
Hsap\LRRC74A
1 of 14
No
Yes
Hsap\LRRC74B
1 of 14
No
Yes
Hsap\NLRC3
1 of 14
No
No
Hsap\NLRC5
1 of 14
No
Yes
Hsap\NLRP2
1 of 14
No
Yes
Hsap\NLRP3
1 of 14
No
No
Hsap\NLRP5
1 of 14
No
Yes
Hsap\NLRP8
1 of 14
No
Yes
Hsap\NLRP9
1 of 14
No
No
Hsap\NLRP12
1 of 14
No
Yes
Hsap\NLRP13
1 of 14
No
Yes
Hsap\NLRP14
1 of 14
No
No
Hsap\NOD1
1 of 14
No
No
Hsap\NOD2
1 of 14
No
Yes
Hsap\RNH1
1 of 14
No
No
Hsap\TCTE1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (9)
Rnor\Rangap1
13 of 14
Yes
Yes
Rnor\Lrrc31
1 of 14
No
Yes
Rnor\Lrrc34
1 of 14
No
No
Rnor\Lrrc74a
1 of 14
No
Yes
Rnor\Nlrc3
1 of 14
No
Yes
Rnor\Nlrp3
1 of 14
No
Yes
Rnor\Nod1
1 of 14
No
No
Rnor\Tcte1
1 of 14
No
No
Rnor\Tonsl
1 of 14
No
No
Mus musculus (laboratory mouse) (9)
Mmus\Rangap1
12 of 14
Yes
Yes
Mmus\Lrrc34
1 of 14
No
No
Mmus\Lrrc74a
1 of 14
No
Yes
Mmus\Nlrc3
1 of 14
No
No
Mmus\Nlrc5
1 of 14
No
No
Mmus\Nlrp3
1 of 14
No
Yes
Mmus\Nlrp9a
1 of 14
No
No
Mmus\Nlrp12
1 of 14
No
Yes
Mmus\Nod1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (8)
Xtro\rangap1
10 of 13
Yes
Yes
Xtro\LOC733866
1 of 13
No
Yes
Xtro\LOC100493539
1 of 13
No
Yes
Xtro\lrrc34
1 of 13
No
No
Xtro\lrrc45
1 of 13
No
Yes
Xtro\lrrc74a
1 of 13
No
Yes
Xtro\tcte1
1 of 13
No
No
Xtro\tmx4
1 of 13
No
No
Danio rerio (Zebrafish) (41)
Drer\rangap1a
13 of 14
Yes
Yes
Drer\rangap1b
13 of 14
Yes
Yes
Drer\LOC100329836
2 of 14
No
Yes
Drer\ciita
1 of 14
No
Yes
Drer\LOC568664
1 of 14
No
Yes
Drer\LOC569265
1 of 14
No
Yes
Drer\LOC100150280
1 of 14
No
Yes
Drer\LOC100333051
1 of 14
No
Yes
Drer\LOC100334101
1 of 14
No
Yes
Drer\LOC103911012
1 of 14
No
Yes
Drer\LOC108183940
1 of 14
No
Yes
Drer\LOC110437710
1 of 14
No
Yes
Drer\lrrc34
1 of 14
No
No
Drer\lrrc74a
1 of 14
No
Yes
Drer\lrrc74b
1 of 14
No
Yes
Drer\nlrc3
1 of 14
No
Yes
Drer\nlrc6
1 of 14
No
Yes
Drer\nlrc7
1 of 14
No
Yes
Drer\nlrc8
1 of 14
No
Yes
Drer\nlrp12l
1 of 14
No
Yes
Drer\si:ch73-24k9.2
1 of 14
No
Yes
Drer\si:ch73-168d20.1
1 of 14
No
Yes
Drer\si:ch211-22k7.9
1 of 14
No
Yes
Drer\si:ch211-76m11.5
1 of 14
No
Yes
Drer\si:ch211-149a19.3
1 of 14
No
Yes
Drer\si:ch211-181d7.1
1 of 14
No
Yes
Drer\si:ch211-196h16.4
1 of 14
No
Yes
Drer\si:ch211-196h16.5
1 of 14
No
Yes
Drer\si:ch211-196h24.1
1 of 14
No
Yes
Drer\si:ch211-213a13.9
1 of 14
No
Yes
Drer\si:ch211-233m11.1
1 of 14
No
Yes
Drer\si:dkey-13n15.11
1 of 14
No
Yes
Drer\si:dkey-23k10.2
1 of 14
No
Yes
Drer\si:dkey-23k10.3
1 of 14
No
Yes
Drer\si:dkey-51d8.1
1 of 14
No
Yes
Drer\si:dkey-121n8.7
1 of 14
No
Yes
Drer\si:dkey-178j11.5
1 of 14
No
Yes
Drer\si:dkeyp-77c4.1
1 of 14
No
Yes
Drer\si:zfos-364h11.1
1 of 14
No
Yes
Drer\zgc:173709
1 of 14
No
Yes
Drer\zgc:174944
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\ran-2
8 of 14
Yes
Yes
Cele\F28C1.3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP008267
11 of 12
Yes
Yes
Agam\AgaP_AGAP005805
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\RANGAP1
8 of 13
Yes
Yes
Atha\RANGAP2
7 of 13
No
Yes
Atha\AT3G06000
4 of 13
No
Yes
Atha\AT1G74360
1 of 13
No
Yes
Atha\emb2004
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\RNA1
11 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\rna1
10 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:RanGAP. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 5 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RANGAP1; Ran GTPase activating protein 1
    13 of 14
    602362
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        RanGAP - AIF
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - Ask1
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - Bcs1
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - CG1513
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - CG9205
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - Dredd
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Fukuyama et al., 2012)
        RanGAP - Fs(2)Ket
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - GAPcenA
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - Nemp
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - Nup358
        pull down, molecular weight estimation by staining, experimental knowledge based, anti bait coimmunoprecipitation, western blot
        (Chen et al., 2021, Guruharsha et al., 2011)
        RanGAP - Nxt1
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - Pten
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        RanGAP - Sk2
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - Tsc1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        RanGAP - az2
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - cert
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - cliff
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - ft
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Kwon et al., 2013)
        RanGAP - gig
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        RanGAP - l(2)k01209
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - rdgB
        experimental knowledge based
        (Guruharsha et al., 2011)
        RanGAP - sbr
        experimental knowledge based
        (Guruharsha et al., 2011)
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        RanGAP
        enhanceable
        aub
        (Gell and Reenan, 2013)
        RanGAP
        enhanceable
        cuff
        (Gell and Reenan, 2013)
        RanGAP
        enhanceable
        Fs(2)Ket
        (Virágh et al., 2012)
        RanGAP
        enhanceable
        piwi
        (Gell and Reenan, 2013)
        RanGAP
        suppressible
        Ran
        (Kusano et al., 2001)
        RanGAP
        suppressible
        Rcc1
        (Wu et al., 2019, Kusano et al., 2001)
        RanGAP
        enhanceable
        squ
        (Gell and Reenan, 2013)
        RanGAP
        suppressible
        squ
        (Gell and Reenan, 2013)
        RanGAP
        suppressible
        Su(Sd)2a-1
        (McDaniel et al., 2002)
        RanGAP
        suppressible
        Su(Sd)4a-2
        (McDaniel et al., 2002)
        RanGAP
        enhanceable
        zuc
        (Gell and Reenan, 2013)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Fs(2)Ket
        enhanceable
        RanGAP
        (Virágh et al., 2012)
        External Data
        Subunit Structure (UniProtKB)
        Forms a complex with Nup358/RanBP2, sbr/Nxf1 and Nxt1 (PubMed:14729961). Associates with the nuclear pore complex via its interaction with Nup358/RanBP2 (PubMed:14729961, PubMed:17032737).
        (UniProt, Q9VIW3 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-54
        Cytogenetic map
        37E1-37E1
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        37E1-37E1
        Limits computationally determined from genome sequence between P{EP}dntEP2158 and P{EP}EP623&P{PZ}spi01068
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        37D2-37D5
        (Merrill, 1999.4.16)
        37D3-37D5
        (determined by in situ hybridisation)
        (Powers and Ganetzky, 1991)
        Experimentally Determined Recombination Data
        Location

        2-54

        (FlyBase, 2016)

        2-53.7

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (15)
        Genomic Clones (17)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (59)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Merrill et al., 1999)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            aub mutations act as genetic enhancers of Segregation Distorter. This effect is still seen when aub mutations are targeted (by homologous recombination) to the Dp(2;2)RanGAPSD chromosome, indicating that the effect of aub mutations is not specific to the target Rsp-bearing chromosome.

            (Gell and Reenan, 2013)

            Area matching Drosophila gene RanGAP, Acc. No. AF143860.

            (Davies, 2001.3.15)

            The truncated RanGap product encoded by SD distorting chromosomes (RanGapSD) retains normal enzyme activity, but has abnormal subcellular location, being distributed diffusely throughout the cytoplasm and also having a distinct nuclear component in primary spermatocytes and salivary gland cells. Mislocalisation of the active RanGapSD product to the nucleus is responsible for segregation distortion (distortion is abolished if enzymatic activity or nuclear localisation of the RanGapSD product is perturbed).

            (Kusano et al., 2001)

            SD chromosomes have a tandem duplication at the RanGap locus. Distortion is caused by a truncated RanGap product encoded by the distal half of the duplication.

            (Merrill et al., 1999)

            A mutation of RanGap generated by loss of a P-element in RanGap exhibits a maternal effect embryonic lethal phenotype. Homozygous females are completely normal but hemizygotes are sterile regardless of the genotype of the male. Embryos from these females die before the syncytial blastoderm stage, around the 7th or 8th nuclear division. In addition, their nuclei are no longer mitotically synchronous and many appear abnormal in size and shape.

            (McLean et al., 1997)

            Encodes a Ran GTPase activator.

            Relationship to Other Genes
            Source for database merge of
            Additional comments
            Nomenclature History
            Source for database identify of

            Source for identity of: RanGAP RanGap

            (FlyBase, 2009-)
            Nomenclature comments

            'RanGap' changed to 'RanGAP' to capitalize the 'GAP' to be consistent with all other GAP gene symbols.

            (FlyBase, 2009-)
            Etymology
            Synonyms and Secondary IDs (24)
            Reported As
            Symbol Synonym
            CG9999
            (National Institute of Genetics Fly Stocks, 2022-, Kolkhof et al., 2017, Hosono et al., 2015, Müller et al., 2010, Keleman et al., 2009.8.5, Mason and Goldfarb, 2009, Perkins et al., 2009, Haussmann et al., 2008, Giot et al., 2003, Brody et al., 2002)
            CT28175
            (Hynes and Zhao, 2000)
            RGP1_DROME
            (Fukuyama et al., 2012)
            Ran
            (Kim et al., 2008)
            RanGAP
            (Klumpe et al., 2025, Turtapkina et al., 2025, Collins et al., 2024, Hegde and Srivastava, 2022, Kim et al., 2021, Liguori et al., 2021, Yang, 2021, Carnesecchi et al., 2020, Cunningham et al., 2020, Gingell and McLean, 2020, Park et al., 2020, Litao et al., 2019.5.24, Solomon et al., 2018, Yuva-Aydemir et al., 2018, Litovchenko and Laurent, 2016, Aradska et al., 2015, Brand et al., 2015, Zhang et al., 2015, Gell and Reenan, 2013, Kwon et al., 2013, Sawamura, 2012, Virágh et al., 2012, Cesario and McKim, 2011, Liu et al., 2011, Moshkin et al., 2009, McElroy and McLean, 2006, Silverman-Gavrila and Wilde, 2006, Xylourgidis et al., 2006, Minakhina et al., 2005, Kusano et al., 2003, Roth et al., 2003, Johnson, 2002, Trieselmann and Wilde, 2002, Kusano et al., 2001)
            RanGAP1
            (Aggarwal et al., 2022)
            RanGap
            (Ota et al., 2021, Kwon et al., 2013, Neumüller et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Steiner et al., 2012, Friedman et al., 2011, Neumüller et al., 2011, Schrider et al., 2011, Müller et al., 2010, Casper and Van Doren, 2009, Obbard et al., 2009, Bakal et al., 2007, Sinkins and Gould, 2006)
            RanGap1
            (Houtchens and Lyttle, 2003)
            Rangap
            (Boeynaems et al., 2016)
            SD
            (Minakhina et al., 2004, Houtchens and Lyttle, 2003, Lyttle, 2002, McDaniel et al., 2002, Sergeev et al., 2001, Kelly and Wade, 2000, Singh, 2000, Stadler, 1996, Hurst, 1993)
            Scl
            (Hynes and Zhao, 2000)
            Sd
            (Navarro-Dominguez et al., 2022, Bachtrog, 2020, Kasbekar, 2020, Shatskikh et al., 2020, Courret et al., 2019, Ferree and Prasad, 2012, Sawamura, 2012, Haussmann et al., 2008, McElroy et al., 2008, McLean et al., 2008, McElroy and McLean, 2006, Tanji et al., 2006, Gibson et al., 2005, Minakhina et al., 2005, Barrio and de Celis, 2004, Dimova et al., 2003, Moschetti et al., 1996, Palopoli and Wu, 1996, Merrill and Ganetzky, 1995, McLean et al., 1994, Palopoli et al., 1994, Dominguez et al., 1993, Hiraizumi, 1993, Gatti and Pimpinelli, 1992, Powers and Ganetzky, 1991, Temin, 1991, Temin et al., 1991, Hiraizumi, 1990, Hiraizumi, 1989, Pimpinelli and Dimitri, 1989, Walker et al., 1989, Temin and Marthas, 1984, Brittnacher and Ganetzky, 1983, Hiraizumi et al., 1980)
            Sd-RanGAP
            (Kasbekar, 2020, McLean et al., 2008, Minakhina et al., 2005)
            Sd-RanGap
            (Presgraves et al., 2009)
            dRanGAP
            (Merrill et al., 1999)
            dmRanGAP
            (Chen et al., 2021)
            ranGAP
            (Hampoelz et al., 2019, Reid et al., 2012, Maybeck and Röper, 2009, Minakhina et al., 2004)
            ranGap
            (Mason and Goldfarb, 2009)
            rangap
            (Wu et al., 2019, Merrill et al., 1998)
            Name Synonyms
            Ran GTPase Activating Protein
            (Gell and Reenan, 2013, Sawamura, 2012)
            Ran GTPase activating protein
            (Minakhina et al., 2005)
            Ran-GTPase activating protein
            (Brand et al., 2015)
            Segregation Distorter
            (Brand et al., 2015, Houtchens and Lyttle, 2003)
            Segregation distorter
            (Lauria Sneideman and Meller, 2021, Presgraves et al., 2009, McLean et al., 2008, Dimitri et al., 2003, Sergeev et al., 2001, McLean et al., 1994)
            Secondary FlyBase IDs
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 56 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (245)