FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\IKKβ
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General Information
Symbol
Dmel\IKKβ
Species
D. melanogaster
Name
I-kappaB kinase β
Annotation Symbol
CG4201
Feature Type
protein_coding_gene
FlyBase ID
FBgn0024222
Gene Model Status
Current
Stock Availability
13 publicly available
Enzyme Name (EC)
IkappaB kinase (2.7.11.10)
Gene Summary
I-kappaB kinase β (IKKβ) encodes a a component of the IκB Kinase (IKK) complex together with the product of key. IKK complex participates in the activation of the transcription factor encoded by Rel in the immune deficiency pathway. This pathway regulates the antibacterial response and other less characterized cellular processes. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

ird5, DmIKKβ, IKK, IKK-β, ird-5

Key Links
Genomic Location
Cytogenetic map
89B1-89B1
Sequence location
Recombination map
3-58
RefSeq locus
NT_033777 REGION:16046347..16049421
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:Q9GYV5
(Silverman et al., 2000)
inferred from physical interaction with UniProtKB:Q03017
(Kim et al., 2000)
enables protein serine/threonine kinase activity
inferred from direct assay
(Ertürk-Hasdemir et al., 2009)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719
(InterPro Project Members, 2004-)
contributes_to IkappaB kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000540281
(GO Reference Genome Project, 2011-)
enables protein kinase activity
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271
(InterPro Project Members, 2004-)
enables protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN001491808
(GO Reference Genome Project, 2011-)
Biological Process (12 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
involved_in antibacterial humoral response
inferred from mutant phenotype
(Lu et al., 2001)
involved_in cellular response to hypoxia
inferred from mutant phenotype
(Bandarra et al., 2014)
involved_in cGAS/STING signaling pathway
inferred from mutant phenotype
(Goto et al., 2018)
involved_in defense response to virus
inferred from mutant phenotype
(Goto et al., 2018, Costa et al., 2009)
involved_in peptidoglycan recognition protein signaling pathway
inferred from mutant phenotype
(Ertürk-Hasdemir et al., 2009, Silverman et al., 2003)
involved_in positive regulation of antibacterial peptide biosynthetic process
inferred from mutant phenotype
(Wu and Anderson, 1998)
inferred from direct assay
(Kim et al., 2000)
involved_in positive regulation of canonical NF-kappaB signal transduction
inferred from mutant phenotype
(Bandarra et al., 2014)
involved_in positive regulation of defense response to virus by host
inferred from mutant phenotype
(Avadhanula et al., 2009)
involved_in protein catabolic process
inferred from direct assay
(Silverman et al., 2000)
involved_in regulation of innate immune response
inferred from mutant phenotype
(Bandarra et al., 2015)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in positive regulation of canonical NF-kappaB signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000540281
(GO Reference Genome Project, 2011-)
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000540281
(GO Reference Genome Project, 2011-)
involved_in tumor necrosis factor-mediated signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000540281
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Silverman et al., 2000)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN001491808
(GO Reference Genome Project, 2011-)
part_of IkappaB kinase complex
inferred from biological aspect of ancestor with PANTHER:PTN000540281
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (Q9VEZ5)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
protein serine/threonine kinase activity
IkappaB kinase activity
L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+) (2.7.11.10)
RHEA 19073:
Summaries
Gene Snapshot
I-kappaB kinase β (IKKβ) encodes a a component of the IκB Kinase (IKK) complex together with the product of key. IKK complex participates in the activation of the transcription factor encoded by Rel in the immune deficiency pathway. This pathway regulates the antibacterial response and other less characterized cellular processes. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
UNCLASSIFIED CONVENTIONAL PROTEIN KINASE DOMAIN KINASES -
This group comprises conventional protein kinase domain kinases that do not classify under other groups in FlyBase.
Pathway (FlyBase)
IMD SIGNALING PATHWAY CORE COMPONENTS -
The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
CGAS-STING SIGNALING PATHWAY CORE COMPONENTS -
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is an anti-viral pattern recognition pathway. In Drosophila, cyclic GMP-AMP (cGAMP) synthases are activated by viral infection, cGAMP is in turn detected by STING ultimately resulting in the activation the NF-κB-like factor Rel and its translocation into the nucleus to activate the transcription of anti-viral genes. (Adapted from FBrf0252868.)
Protein Function (UniProtKB)
Required for the activation of the NF-kappa-B factor Relish (Rel) by acting as an essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for direct activation of Rel (PubMed:10636911, PubMed:11018014, PubMed:11156609, PubMed:30119996). Phosphorylates inhibitors of NF-kappa-B (cact) thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the NF-kappa-B inhibitor (PubMed:10636911, PubMed:11018014, PubMed:11156609). Essential for antibacterial immune response (PubMed:11018014). Also required for antiviral immune response (PubMed:30119996).
(UniProt, Q9VEZ5)
Summary (Interactive Fly)

IkappaB kinase, respectively IKK regulatory and catalytic subunits - induction of antimicrobial peptide genes

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\IKKβ for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VEZ5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.55

Low-frequency RNA-Seq exon junction(s) not annotated.

Shares 5' exon(s) with upstream non-coding gene; shared promoter.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
IKKβ-RB
FBtr0304804
NM_080012
2488
717
Additional Transcript Data and Comments
Reported size (kB)

2.476 (longest cDNA)

(Kim et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
IKKβ-PB
FBpp0293344
82.6
717
8.02
Q9VEZ5
NP_524751
AAF55267
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

731 (aa); 84 (kD predicted)

(Kim et al., 2000)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with key to form the I-kappa-B kinase complex. In vitro, interacts with cact.

(UniProt, Q9VEZ5)
Post Translational Modification

Autophosphorylated; upon LPS stimulation it is transiently activated, and can be autophosphorylated.

(UniProt, Q9VEZ5)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\IKKβ using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.37

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
embryonic stage 9 -- 10
germline cell
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
fat body/gonad primordium
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
germline cell
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
pcr
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Kim et al., 2000)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult Malpighian tubule
(McGettigan et al., 2005)
Additional Descriptive Data

IKK is constitutively expressed at all developmental stages.

(Kim et al., 2000)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Silverman et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\IKKβ in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of IKKβ
Transgenic constructs containing regulatory region of IKKβ
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(3R)Exel7328
(Ryder, 2004.4.26)
Df(3R)sbd45
(Lu et al., 2001, Wu et al., 2001)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (69)
Hsap\CHUK
10 of 14
Yes
Yes
Hsap\IKBKB
10 of 14
Yes
Yes
1  
Hsap\IKBKE
2 of 14
No
No
1  
Hsap\TBK1
2 of 14
No
No
2  
Hsap\AURKC
1 of 14
No
No
Hsap\BUB1B-PAK6
1 of 14
No
No
Hsap\CDK5
1 of 14
No
No
2  
Hsap\CDK18
1 of 14
No
No
Hsap\CDKL2
1 of 14
No
No
5  
Hsap\CDKL3
1 of 14
No
No
1  
Hsap\CDKL4
1 of 14
No
No
1  
Hsap\CHEK1
1 of 14
No
No
1  
Hsap\CILK1
1 of 14
No
No
Hsap\DAPK1
1 of 14
No
No
4  
Hsap\DAPK2
1 of 14
No
Yes
Hsap\DAPK3
1 of 14
No
No
Hsap\DCLK1
1 of 14
No
No
Hsap\DCLK3
1 of 14
No
No
Hsap\EPHB4
1 of 14
No
No
Hsap\GRK6
1 of 14
No
No
Hsap\MAK
1 of 14
No
No
Hsap\MAP3K1
1 of 14
No
Yes
Hsap\MAP3K4
1 of 14
No
No
Hsap\MAP4K2
1 of 14
No
No
Hsap\MAP4K5
1 of 14
No
No
Hsap\MAPKAPK2
1 of 14
No
No
Hsap\MAPKAPK3
1 of 14
No
No
1  
Hsap\MYLK3
1 of 14
No
No
Hsap\MYLK4
1 of 14
No
No
Hsap\MYLK
1 of 14
No
No
Hsap\MYO3B
1 of 14
No
No
Hsap\NEK2
1 of 14
No
No
Hsap\NEK7
1 of 14
No
No
Hsap\NUAK1
1 of 14
No
No
2  
Hsap\NUAK2
1 of 14
No
No
2  
Hsap\OXSR1
1 of 14
No
No
Hsap\PAK6
1 of 14
No
No
Hsap\PHKG1
1 of 14
No
No
Hsap\PNCK
1 of 14
No
No
1  
Hsap\PRKAA1
1 of 14
No
No
2  
Hsap\PRKAA2
1 of 14
No
No
Hsap\PRKACA
1 of 14
No
No
Hsap\PRKACB
1 of 14
No
No
Hsap\PRKACG
1 of 14
No
No
Hsap\PRKCH
1 of 14
No
No
Hsap\PRKD1
1 of 14
No
No
2  
Hsap\PRKD2
1 of 14
No
No
1  
Hsap\PRKD3
1 of 14
No
No
1  
Hsap\PRKG2
1 of 14
No
No
1  
Hsap\PRKX
1 of 14
No
No
Hsap\PSKH1
1 of 14
No
No
Hsap\RPS6KA1
1 of 14
No
No
Hsap\RPS6KA2
1 of 14
No
No
Hsap\RPS6KA3
1 of 14
No
No
1  
Hsap\RPS6KA5
1 of 14
No
No
Hsap\RPS6KA6
1 of 14
No
No
1  
Hsap\SIK1B
1 of 14
No
No
Hsap\SIK1
1 of 14
No
No
1  
Hsap\SIK2
1 of 14
No
No
Hsap\SLK
1 of 14
No
No
6  
Hsap\STK10
1 of 14
No
No
Hsap\STK17B
1 of 14
No
No
1  
Hsap\STK36
1 of 14
No
No
1  
Hsap\STK39
1 of 14
No
No
Hsap\TAOK1
1 of 14
No
No
Hsap\TAOK2
1 of 14
No
No
4  
Hsap\ULK2
1 of 14
No
No
Hsap\ULK3
1 of 14
No
No
Hsap\ULK4
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (49)
Rnor\Chuk
10 of 14
Yes
Yes
Rnor\Ikbkb
10 of 14
Yes
Yes
Rnor\Ikbke
2 of 14
No
No
Rnor\Tbk1
2 of 14
No
No
Rnor\Akt2
1 of 14
No
No
Rnor\Cdk5
1 of 14
No
No
Rnor\Chek1
1 of 14
No
No
Rnor\Cilk1
1 of 14
No
No
Rnor\Dapk1
1 of 14
No
No
Rnor\Dapk2
1 of 14
No
No
Rnor\Dapk3
1 of 14
No
No
Rnor\Dclk1
1 of 14
No
No
Rnor\Dclk2
1 of 14
No
No
Rnor\Dclk3
1 of 14
No
No
Rnor\Ephb4
1 of 14
No
No
Rnor\Grk4
1 of 14
No
No
Rnor\Grk6
1 of 14
No
No
Rnor\LOC690235
1 of 14
No
No
Rnor\LOC102551633
1 of 14
No
No
Rnor\Mak
1 of 14
No
No
Rnor\Map3k1
1 of 14
No
Yes
Rnor\Mapkapk2
1 of 14
No
No
Rnor\Mylk4
1 of 14
No
No
Rnor\Mylk
1 of 14
No
No
Rnor\Nek4
1 of 14
No
No
Rnor\Nek5
1 of 14
No
No
Rnor\Nuak1
1 of 14
No
No
Rnor\Nuak2
1 of 14
No
No
Rnor\Oxsr1
1 of 14
No
No
Rnor\Phkg1
1 of 14
No
No
Rnor\Pnck
1 of 14
No
No
Rnor\Prkaa1
1 of 14
No
No
Rnor\Prkaa2
1 of 14
No
No
Rnor\Prkaca
1 of 14
No
No
Rnor\Prkacb
1 of 14
No
No
Rnor\Prkd1
1 of 14
No
No
Rnor\Prkd2
1 of 14
No
No
Rnor\Prkd3
1 of 14
No
No
Rnor\Pskh1
1 of 14
No
No
Rnor\Rps6ka3
1 of 14
No
No
Rnor\Rps6ka6
1 of 14
No
No
Rnor\Sik1
1 of 14
No
No
Rnor\Stk10
1 of 14
No
No
Rnor\Stk36
1 of 14
No
No
Rnor\Stk39
1 of 14
No
No
Rnor\Taok1
1 of 14
No
No
Rnor\Ttk
1 of 14
No
No
Rnor\Ulk2
1 of 14
No
No
Rnor\Ulk3
1 of 14
No
No
Mus musculus (laboratory mouse) (63)
Mmus\Chuk
10 of 14
Yes
Yes
Mmus\Ikbkb
9 of 14
No
Yes
Mmus\Ikbke
2 of 14
No
No
Mmus\Tbk1
2 of 14
No
No
Mmus\4921509C19Rik
1 of 14
No
No
Mmus\Akt2
1 of 14
No
No
Mmus\Cdk5
1 of 14
No
No
Mmus\Cdk6
1 of 14
No
No
Mmus\Cdkl4
1 of 14
No
No
Mmus\Cilk1
1 of 14
No
No
Mmus\Dapk1
1 of 14
No
No
Mmus\Dapk2
1 of 14
No
No
Mmus\Dapk3
1 of 14
No
No
Mmus\Dclk1
1 of 14
No
No
Mmus\Dclk3
1 of 14
No
No
Mmus\Ephb4
1 of 14
No
No
Mmus\Gm4513
1 of 14
No
Yes
Mmus\Gm4565
1 of 14
No
Yes
Mmus\Gm5157
1 of 14
No
No
Mmus\Gm5890
1 of 14
No
Yes
Mmus\Gm5891
1 of 14
No
No
Mmus\Gm6882
1 of 14
No
No
Mmus\Gm7168
1 of 14
No
No
Mmus\Gm7356
1 of 14
No
No
Mmus\Gm10662
1 of 14
No
No
Mmus\Gm14147
1 of 14
No
No
Mmus\Gm14151
1 of 14
No
No
Mmus\Grk4
1 of 14
No
No
Mmus\Grk5
1 of 14
No
No
Mmus\Grk6
1 of 14
No
No
Mmus\Mak
1 of 14
No
No
Mmus\Map3k1
1 of 14
No
Yes
Mmus\Map3k4
1 of 14
No
No
Mmus\Map3k6
1 of 14
No
No
Mmus\Mapkapk2
1 of 14
No
No
1  
Mmus\Mapkapk3
1 of 14
No
No
Mmus\Mylk
1 of 14
No
No
Mmus\Nek5
1 of 14
No
No
Mmus\Nuak1
1 of 14
No
No
Mmus\Nuak2
1 of 14
No
No
Mmus\Oxsr1
1 of 14
No
No
Mmus\Pak1
1 of 14
No
No
Mmus\Phkg1
1 of 14
No
No
Mmus\Pnck
1 of 14
No
No
Mmus\Prkaa1
1 of 14
No
No
Mmus\Prkaa2
1 of 14
No
No
Mmus\Prkaca
1 of 14
No
No
Mmus\Prkacb
1 of 14
No
No
Mmus\Prkd1
1 of 14
No
No
Mmus\Prkd2
1 of 14
No
No
Mmus\Prkd3
1 of 14
No
No
Mmus\Pskh1
1 of 14
No
No
Mmus\Rps6ka3
1 of 14
No
No
Mmus\Rps6ka6
1 of 14
No
No
Mmus\Sik1
1 of 14
No
No
Mmus\Smok1
1 of 14
No
No
Mmus\Smok2a
1 of 14
No
No
Mmus\Stk10
1 of 14
No
No
Mmus\Stk36
1 of 14
No
No
Mmus\Stk39
1 of 14
No
No
Mmus\Taok1
1 of 14
No
No
Mmus\Ulk2
1 of 14
No
No
Mmus\Ulk3
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (33)
Xtro\chuk
7 of 13
Yes
Yes
Xtro\ikbkb
7 of 13
Yes
Yes
Xtro\LOC101732839
7 of 13
Yes
Yes
Xtro\cdk16
1 of 13
No
No
Xtro\cilk1
1 of 13
No
No
Xtro\dapk2
1 of 13
No
Yes
Xtro\dapk3
1 of 13
No
No
Xtro\dclk1
1 of 13
No
No
Xtro\dclk3
1 of 13
No
No
Xtro\ern2
1 of 13
No
No
Xtro\grk1
1 of 13
No
No
Xtro\hunk
1 of 13
No
Yes
Xtro\LOC100145764
1 of 13
No
No
Xtro\LOC100496216
1 of 13
No
No
Xtro\LOC116406512
1 of 13
No
No
Xtro\map3k1
1 of 13
No
Yes
Xtro\map3k2
1 of 13
No
No
Xtro\neu4
1 of 13
No
No
Xtro\nuak1
1 of 13
No
No
Xtro\nuak2
1 of 13
No
No
Xtro\prkaa1
1 of 13
No
No
Xtro\prkaca
1 of 13
No
No
Xtro\prkg2
1 of 13
No
No
Xtro\rheb
1 of 13
No
No
Xtro\rps6ka3
1 of 13
No
No
Xtro\stk10
1 of 13
No
No
Xtro\stk32c
1 of 13
No
No
Xtro\stk39
1 of 13
No
No
Xtro\taok1
1 of 13
No
No
Xtro\tbk1
1 of 13
No
No
Xtro\ulk3
1 of 13
No
No
Xtro\ulk4
1 of 13
No
Yes
Xtro\XB956263
1 of 13
No
No
Danio rerio (Zebrafish) (62)
Drer\chuk
10 of 14
Yes
Yes
Drer\ikbkb
10 of 14
Yes
Yes
Drer\ikbke
2 of 14
No
No
Drer\akt3b
1 of 14
No
No
Drer\camk1db
1 of 14
No
No
Drer\camk1ga
1 of 14
No
No
Drer\cdk5
1 of 14
No
No
Drer\cdk6
1 of 14
No
No
Drer\cdk18
1 of 14
No
No
Drer\cdk21
1 of 14
No
No
Drer\chek2
1 of 14
No
No
Drer\dapk2a
1 of 14
No
No
Drer\dapk3
1 of 14
No
No
Drer\dclk1a
1 of 14
No
No
Drer\dmpk
1 of 14
No
No
Drer\fes
1 of 14
No
No
Drer\grk6
1 of 14
No
No
Drer\LOC100536197
1 of 14
No
No
Drer\LOC101887148
1 of 14
No
Yes
Drer\LOC108182684
1 of 14
No
Yes
Drer\mak
1 of 14
No
No
Drer\map3k1
1 of 14
No
Yes
Drer\map3k3
1 of 14
No
No
Drer\map3k19
1 of 14
No
No
Drer\mapkapk2a
1 of 14
No
No
Drer\melk
1 of 14
No
Yes
Drer\mylk3
1 of 14
No
No
Drer\mylk4b
1 of 14
No
No
Drer\mylk5
1 of 14
No
No
Drer\nek1
1 of 14
No
No
Drer\nek2
1 of 14
No
No
Drer\nek8
1 of 14
No
No
Drer\nim1kb
1 of 14
No
No
Drer\pak6b
1 of 14
No
No
Drer\phkg1b
1 of 14
No
No
Drer\prkaa1
1 of 14
No
No
Drer\prkaa2
1 of 14
No
No
Drer\prkacaa
1 of 14
No
No
Drer\prkacab
1 of 14
No
No
Drer\prkacbb
1 of 14
No
No
Drer\prkd1
1 of 14
No
No
Drer\prkd2
1 of 14
No
No
Drer\prkd3
1 of 14
No
No
Drer\prkx
1 of 14
No
No
Drer\pskh1
1 of 14
No
No
Drer\rps6ka4
1 of 14
No
No
Drer\rps6ka5
1 of 14
No
No
Drer\si:dkey-81j8.6
1 of 14
No
No
Drer\sik2a
1 of 14
No
No
Drer\slka
1 of 14
No
No
Drer\slkb
1 of 14
No
No
Drer\snrkb
1 of 14
No
No
Drer\stk10
1 of 14
No
No
Drer\stk26
1 of 14
No
No
Drer\stk33
1 of 14
No
No
Drer\stk36
1 of 14
No
No
Drer\stk39
1 of 14
No
No
Drer\taok1a
1 of 14
No
No
Drer\taok1b
1 of 14
No
No
Drer\taok2a
1 of 14
No
No
Drer\tbk1
1 of 14
No
No
Drer\ttk
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (28)
Cele\Y39G8B.5
2 of 14
Yes
No
Cele\aak-2
1 of 14
No
No
Cele\air-1
1 of 14
No
No
Cele\C44H4.6
1 of 14
No
No
Cele\cdk-5
1 of 14
No
No
Cele\chk-2
1 of 14
No
No
Cele\cst-1
1 of 14
No
No
Cele\cst-2
1 of 14
No
No
Cele\dkf-2
1 of 14
No
No
Cele\dyf-5
1 of 14
No
No
Cele\ikke-1
1 of 14
No
No
Cele\kin-1
1 of 14
No
No
Cele\kin-18
1 of 14
No
No
Cele\kin-29
1 of 14
No
No
Cele\M03C11.1
1 of 14
No
No
Cele\nekl-1
1 of 14
No
No
Cele\nekl-2
1 of 14
No
No
Cele\pak-1
1 of 14
No
No
Cele\pak-2
1 of 14
No
No
Cele\plk-3
1 of 14
No
No
Cele\pmk-3
1 of 14
No
No
Cele\rskn-2
1 of 14
No
No
Cele\sek-6
1 of 14
No
No
Cele\T08D2.7
1 of 14
No
No
Cele\tag-344
1 of 14
No
No
Cele\unc-43
1 of 14
No
No
Cele\unc-82
1 of 14
No
No
Cele\zyg-1
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (17)
Agam\IKK1
12 of 12
Yes
Yes
Agam\AgaP_AGAP009565
2 of 12
No
No
Agam\AgaP_AGAP000098
1 of 12
No
No
Agam\AgaP_AGAP001384
1 of 12
No
No
Agam\AgaP_AGAP002647
1 of 12
No
No
Agam\AgaP_AGAP002686
1 of 12
No
No
Agam\AgaP_AGAP003158
1 of 12
No
No
Agam\AgaP_AGAP003202
1 of 12
No
No
Agam\AgaP_AGAP003365
1 of 12
No
No
Agam\AgaP_AGAP006872
1 of 12
No
No
Agam\AgaP_AGAP007598
1 of 12
No
No
Agam\AgaP_AGAP007669
1 of 12
No
No
Agam\AgaP_AGAP008341
1 of 12
No
No
Agam\AgaP_AGAP009034
1 of 12
No
No
Agam\AgaP_AGAP010115
1 of 12
No
No
Agam\AgaP_AGAP010874
1 of 12
No
No
Agam\AgaP_AGAP012070
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (44)
Atha\AT1G49180
1 of 13
Yes
No
Atha\AT2G19230
1 of 13
Yes
Yes
Atha\AT2G28960
1 of 13
Yes
No
Atha\AT2G37840
1 of 13
Yes
No
Atha\AT3G46140
1 of 13
Yes
Yes
Atha\AT3G53930
1 of 13
Yes
No
Atha\AT4G31170
1 of 13
Yes
No
Atha\AT5G18700
1 of 13
Yes
No
Atha\AT5G47070
1 of 13
Yes
No
Atha\AT5G50180
1 of 13
Yes
No
Atha\AUR1
1 of 13
Yes
No
Atha\CIPK8
1 of 13
Yes
No
Atha\CIPK12
1 of 13
Yes
No
Atha\CIPK21
1 of 13
Yes
No
Atha\CIPK23
1 of 13
Yes
No
Atha\CPK1
1 of 13
Yes
No
Atha\CPK2
1 of 13
Yes
No
Atha\CPK19
1 of 13
Yes
No
Atha\CPK20
1 of 13
Yes
No
Atha\CPK21
1 of 13
Yes
No
Atha\CPK22
1 of 13
Yes
No
Atha\CPK28
1 of 13
Yes
No
Atha\KIN10
1 of 13
Yes
No
Atha\KIN11
1 of 13
Yes
No
Atha\MAPKKK14
1 of 13
Yes
Yes
Atha\MAPKKK15
1 of 13
Yes
Yes
Atha\MEK1
1 of 13
Yes
No
Atha\MKK2
1 of 13
Yes
No
Atha\MKK4
1 of 13
Yes
No
Atha\MKK7
1 of 13
Yes
No
Atha\MKK8
1 of 13
Yes
No
Atha\MKK9
1 of 13
Yes
No
Atha\MKK10
1 of 13
Yes
No
Atha\MPK12
1 of 13
Yes
No
Atha\NEK1
1 of 13
Yes
No
Atha\OST1
1 of 13
Yes
No
Atha\PEPKR1
1 of 13
Yes
No
Atha\SIP3
1 of 13
Yes
No
Atha\SIP4
1 of 13
Yes
No
Atha\SNRK2.3
1 of 13
Yes
No
Atha\SNRK2.5
1 of 13
Yes
No
Atha\SNRK2.7
1 of 13
Yes
No
Atha\SNRK2.9
1 of 13
Yes
No
Atha\TMK1
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (11)
Scer\ATG1
1 of 13
Yes
No
Scer\BCK1
1 of 13
Yes
No
Scer\KIC1
1 of 13
Yes
No
Scer\KIN1
1 of 13
Yes
No
Scer\MCK1
1 of 13
Yes
No
Scer\SNF1
1 of 13
Yes
No
Scer\SPS1
1 of 13
Yes
No
Scer\STE11
1 of 13
Yes
No
Scer\STE20
1 of 13
Yes
No
Scer\TOS3
1 of 13
Yes
No
Scer\TPK1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (8)
Spom\cdr1
1 of 12
Yes
No
Spom\kin1
1 of 12
Yes
No
Spom\mek1
1 of 12
Yes
No
Spom\mkh1
1 of 12
Yes
No
Spom\nak1
1 of 12
Yes
No
Spom\pck2
1 of 12
Yes
No
Spom\pka1
1 of 12
Yes
No
Spom\win1
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:IKKβ. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (20)
IKKε
4 of 13
Aduk
1 of 13
Akt
1 of 13
AMPKα
1 of 13
aPKC
1 of 13
Atg1
1 of 13
CG12069
1 of 13
CG17528
1 of 13
CG42366
1 of 13
hpo
1 of 13
KP78b
1 of 13
mbt
1 of 13
Mekk1
1 of 13
niki
1 of 13
Pask
1 of 13
PhKγ
1 of 13
Pka-C1
1 of 13
Pka-C3
1 of 13
S6kII
1 of 13
sqa
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CHUK; component of inhibitor of nuclear factor kappa B kinase complex
    10 of 14
    600664
    IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
    10 of 14
    603258
     
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    IKKβ
    enhanceable
    GluRIIA
    (Harris et al., 2018)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Arms
    suppressible
    IKKβ
    (Liao et al., 2023)
    External Data
    Subunit Structure (UniProtKB)
    Interacts with key to form the I-kappa-B kinase complex. In vitro, interacts with cact.
    (UniProt, Q9VEZ5 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-58
    Cytogenetic map
    89B1-89B1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    89B1-89B1
    Limits computationally determined from genome sequence between P{PZ}blp01618 and P{PZ}gish04895&P{EP}EP3171
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    89B-89B
    (Silverman, 2000.8.8, Lu et al., 1999)
    89B-89B
    (determined by in situ hybridisation)
    (Kim et al., 2000)
    89A-89B
    (Inohara, 1999.9.28)
    Experimentally Determined Recombination Data
    Location

    3-58

    (FlyBase, 2016)

    3-57.9

    (Comeron et al., 2012)

    3-

    (Wu et al., 2001, Wu and Anderson, 1998)
    Left of (cM)
    (Lu et al., 2001)
    (Lu et al., 2001, Wu et al., 2001, Wu and Anderson, 1998)
    Right of (cM)
    (Lu et al., 2001)
    (Lu et al., 2001, Wu et al., 2001, Wu and Anderson, 1998)
    Notes
    Stocks and Reagents
    Stocks (13)
    Genomic Clones (19)
    cDNA Clones (102)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)

          Mutants show no detectable induction of Dpt, CecA1, CecA2, Def, Dro or Mtk on bacterial challenge. Attacin levels are 30% wild type and Drs induction is normal. In direction of increasing cytology: pnr+ ird5- msps+ Akt1+

          (Lu et al., 2001)

          ird5 is specifically required for the activation of Rel.

          (Lu et al., 2001)

          A small fraction of embryos produced by homozygous mutant females show a weakly dorsalized phenotype.

          (Shapiro and Anderson, 2001)

          Identification: as a mutation that fails to induce expression of Ecol\lacZDpt.PR normally in response to infection. 2 alleles have been obtained.

          (Wu et al., 2001)

          ird5 is required for the activation of the antibacterial immune response genes.

          (Silverman et al., 2000)

          Identification: transcription unit identified during molecular analysis of the msps genomic region.

          (Cullen et al., 1999)

          Encodes a Drosophila I-ΚB kinase.

          (Lu et al., 1999)

          Components of the immune response are identified in a screen for the failure to induce a Dpt (an antibacterial peptide) Ecol\lacZ reporter gene.

          (Wu and Anderson, 1998)

          Mutants are impaired in their induction of Dpt, but show distinct regulation of the two transcription factors, dl and Dif, implicated in the immune response.

          (Wu and Anderson, 1998)

          Identification: EMS screen for mutations that prevent Dpt expression in response to infection.

          (Wu and Anderson, 1998)

          Mutants exhibit a constitutive Dif nuclear localisation.

          (Wu and Anderson, 1998)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: IKK ird5

          (Wasserman, 2000)

          Source for merge of: ird5 anon-89Bd

          (Lu et al., 2001)

          Source for merge of: IKK IK

          (FlyBase, 1996-)

          Source for merge of: IKK LPS-responsive-kinase

          (FlyBase, 1996-)
          Additional comments

          Source for merge of IKK IK was sequence comparison ( date:000202 ).

          (FlyBase, 1996-)

          Source for merge of IKK LPS-responsive-kinase was sequence comparison ( date:000306 ).

          (FlyBase, 1996-)
          Nomenclature History
          Source for database identify of

          Source for identity of: IKKβ ird5

          (FlyBase, 2009-)
          Nomenclature comments

          Renamed from the placeholder symbol 'ird5' to 'IKKβ', which is the preferred symbol in the published literature.

          (FlyBase, 2009-)
          Etymology
          Synonyms and Secondary IDs (49)
          Reported As
          Symbol Synonym
          CG4201
          (Meadows, 2017.1.11, Neuert et al., 2017, Hosono et al., 2015, Meadows, 2014.12.12, Douglas et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Perkins et al., 2009, Mount, 2001.8.14, Morrison et al., 2000)
          DIK
          (Inohara, 1999.9.28)
          DLAK
          (Bergmann, 2006, Kim et al., 2000)
          DmIKK
          (Zhou et al., 2001, Silverman et al., 2000)
          DmIKKb
          (Erturk et al., 2003)
          DmIKKΒ
          (Lu et al., 2001)
          DmIKKβ
          (Fukuyama et al., 2013, Pal et al., 2007, Bergmann, 2006, Tauszig-Delamasure et al., 2002, Zhou et al., 2002, Shapiro and Anderson, 2001, Silverman and Maniatis, 2001, Silverman and Maniatis, 2001, Vidal et al., 2001, Zhou et al., 2001, Khush and Lemaitre, 2000, Silverman et al., 2000, Wasserman, 2000)
          DmIkkβ
          (Khush et al., 2002)
          Dmikkb
          (Zsindely et al., 2009)
          Dmikkβ
          (Lemaitre, 2000.12.20)
          IK
          IKK
          (Aparicio et al., 2013, Steiner, 2004, Jasper and Bohmann, 2002, Sun et al., 2002, Coulier et al., 2000)
          IKK-β
          (Keebaugh and Schlenke, 2014, Kingsolver et al., 2013, Akira et al., 2006, Leclerc and Reichhart, 2004, Hoffmann, 2003)
          IKKB
          (Fukuyama et al., 2013, Kimbrell and Beutler, 2001)
          IKKBeta
          (Blount et al., 2020)
          IKKb
          (Buhlman et al., 2021, Cully et al., 2010, Waterhouse et al., 2007)
          IKKbeta
          (Nelson et al., 2013)
          IKKβ
          (Zheng et al., 2025, Adeyemi et al., 2024, Balakireva et al., 2024, Chen et al., 2023, Collins et al., 2023, Khan et al., 2023, Kuyateh and Obbard, 2023, Cai et al., 2022, Cheung et al., 2022, Liegeois and Ferrandon, 2022, Wang et al., 2022, Ferguson et al., 2021, Padash Barmchi et al., 2021, Salem Wehbe et al., 2021, Schneider and Imler, 2021, Sciambra and Chtarbanova, 2021, Davis and Rebay, 2018, Harris et al., 2018, Kounatidis and Chtarbanova, 2018, Mussabekova et al., 2017, Bischof and FlyORF project members, 2014.6.20, Imler, 2014, Buchon et al., 2013, Liu et al., 2012, Ertürk-Hasdemir et al., 2009, Obbard et al., 2009, Waterhouse et al., 2007, Kim et al., 2006)
          IRD-5
          (Tsichritzis et al., 2007)
          IRD5
          (Rosendo Machado et al., 2021, Arora and Ligoxygakis, 2020, Imler, 2014, Kleino and Silverman, 2014, Fukuyama et al., 2013, Meinander et al., 2012, Vandenabeele and Bertrand, 2012)
          Ik
          (Wasserman, 2000)
          Ikkb
          (Port et al., 2020, Liu et al., 2012)
          Ikkβ
          (Xu and Cherry, 2014, Ertürk-Hasdemir et al., 2009)
          Ird-5
          (Wasserman, 2000)
          Ird5
          (Rai and Bergmann, 2024, Kietz and Meinander, 2023, Williams et al., 2023, Benoit et al., 2022, Cammarata-Mouchtouris et al., 2022, Yu et al., 2022, Zhu et al., 2021, Hegde et al., 2020, Krautz et al., 2020, Badinloo et al., 2018, Moulton and Letsou, 2016, Bandarra et al., 2015, Bandarra et al., 2014, Myllymäki et al., 2014, Eleftherianos and Castillo, 2012, Igboin et al., 2012, Valanne et al., 2011, Valanne et al., 2010, Bond and Foley, 2009, Xi et al., 2008, Dijkers and O'Farrell, 2007, Kuranaga and Miura, 2007)
          LRK
          (Kim, 1999.4.6)
          Lak
          anon-89Bd
          dIKK
          (Mushegian and Medzhitov, 2001)
          dIKK-β
          (Govind and Nehm, 2004)
          dIKKβ
          (Tafesh-Edwards and Eleftherianos, 2020, Kanao et al., 2012)
          dLak
          (Wasserman, 2000)
          dmIKKβ
          (Khush et al., 2002)
          ikk
          (Khush and Lemaitre, 2000)
          ird
          (Peng et al., 2005, Wasserman, 2000)
          ird-5
          (Palmer et al., 2018, Aparicio et al., 2013, Merkling and van Rij, 2013, Garcia et al., 2012)
          ird5
          (Haas et al., 2025, Tendulkar et al., 2022, Gohel et al., 2020, Lu et al., 2020, Al-Ramahi et al., 2018, Goto et al., 2018, Nandy et al., 2018, Christesen et al., 2017, Neuert et al., 2017, Tusco et al., 2017, Bandarra et al., 2015, Dobson et al., 2015, Kanoh et al., 2015, Vedanayagam and Garrigan, 2015, Sopko et al., 2014, Verma and Tapadia, 2014, Aparicio et al., 2013, Fukuyama et al., 2013, Kwon et al., 2013, Liu et al., 2012, Douglas et al., 2011, Hill-Burns and Clark, 2010, Huang et al., 2010, Radyuk et al., 2010, Avadhanula et al., 2009, Costa et al., 2009, Cronin et al., 2009, Ertürk-Hasdemir et al., 2009, Zsindely et al., 2009, Davis et al., 2008, Vonkavaara et al., 2008, Xi et al., 2008, Zhou et al., 2008, Sackton et al., 2007, McGettigan et al., 2005)
          ird5/DmIkkβ
          (Choe et al., 2002)
          ird5
          (Verma and Tapadia, 2015)
          Name Synonyms
          I-kappaB kinase β
          IKK-like protein
          (Inohara, 1999.9.28)
          Immune response deficient 5
          (Vandenabeele and Bertrand, 2012, Radyuk et al., 2010)
          LPS-responsive kinase
          (Kim, 1999.4.6)
          LPS-responsive-kinase
          Lipopolysaccharide activated kinase
          (Kim et al., 2000)
          cactus kinase
          immune response deficient 5
          (Badinloo et al., 2018, Wu and Anderson, 1998, Wu and Anderson, 1998)
          immune response-deficient 5
          (Fukuyama et al., 2013)
          mmune response deficient 5
          Secondary FlyBase IDs
          • FBgn0028725
          • FBgn0028726
          • FBgn0029099
          • FBgn0029160
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 69 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          References (203)