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Gene Dmel\Bap170

General Information
Symbol	Dmel\Bap170	Species	D. melanogaster
Name	Brahma associated protein 170kD	Annotation symbol	CG3274
Feature type	protein_coding_gene	FlyBase ID	FBgn0042085
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	42B2-42B2	Sequence location	2R:2,524,017..2,529,863 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Brahma associated protein 170kD is referred to in FlyBase by the symbol Dmel\Bap170 (CG3274, FBgn0042085). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: negative regulation of chromatin silencing; imaginal disc-derived wing margin morphogenesis; negative regulation of epidermal growth factor receptor signaling pathway; protein stabilization; imaginal disc-derived wing vein morphogenesis; positive regulation of transcription, DNA-dependent; imaginal disc-derived leg morphogenesis; phagocytosis, engulfment. 16 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; leg; mesothoracic tergum; wing vein. It has one annotated transcript and one annotated polypeptide. Protein features are: ARID/BRIGHT DNA-binding domain; DNA-binding RFX-type winged-helix domain; Winged helix-turn-helix transcription repressor DNA-binding domain; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval fat body, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1628423_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Bap170. Gene sequence location is 2R:2524017..2529863.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42B2-42B2
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)	Bc L (Rendina et al., 2010)
Right of (cM)	wg (Rendina et al., 2010)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Bap170 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Gene model reviewed during 5.41 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Bap170-RA FBtr0086107  NM_136372   5316   1688
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Bap170-PA   FBpp0085442   183.0   1688   8.59     NP_610216   AAF57363
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments	The brm core complex appears to comprise 10 polypeptides. These include brm, mor, osa, Bap60, Snr1, dalao, Bap55, Bap170, Bap26,and Act42A or Act5C proteins. (FlyBase Curators et al., 2004-)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ARID/BRIGHT DNA-binding domain (IPR001606) DNA-binding RFX-type winged-helix domain (IPR003150) Zinc finger, C2H2-like (IPR015880) Winged helix-turn-helix DNA-binding domain (IPR011991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA735225   AE013599 AAF57363   AF145672 AAD38647   AI064138   AI108316   AI134652   AI387657   AI402282   AI402774   AI531449   AI532701   BF485658   BF493668   BG633197   BG639561   BI169133   BI236883   BI355270   BI367851   BI481854   BI632592   BI633508   BI635376   BI637976   BI639185   BQ103133   BT012454   CO183127   CO192725   CO282120   CO307849   CO336064   CO343866   EC051329   EC052239   EC053736   EC053823   EC054696   EC056548   EC057964   EC068836   EC088928   EC089032   EC209540   EC210381   EC210889   EC239590   EC248739   EC253828   EC267757   EV575276   GH751213   GH756492   GH757346   GH757621   GH770462   GH773244   GH777474   GH779977   GH780576   GH780671   GH780713   GH783014   GH787035   GH787269   GH796062   GH811686   GH811717   GH816358   GH823834   GH824311   GH826203   GH830056   GH830368   GH833884   GH836362   GH836497   GH836510   GH837257   GH841674   GH843535   GH849896   GH850669   GH854802   GH856596   GH859715   GH866207   GH868000   GH871149   GH873177   GH880514   GH882251   GH882517   GH886901   GH890412   GH892259   GH901363   GH901975   GH903177   GH903225   GH905196   GH905890   GH906005   GH910994   GH912662   GH916599   GH918778   GH920999   GH922913   GH924363   GH927293   GH932163   GH933256   GH933948   GH936736   GH937609   GH938139   GH939976
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z6M0 Q7KMJ0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
brahma complex inferred from direct assay (Kal et al., 2000) polytene chromosome inferred from direct assay (Chalkley et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval fat body, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    352.1 Larval Midgut    48.8 Larval Hindgut    71.5 Larval Malpighian Tubules    48.4 Larval Fat Body    100.4 Larval Salivary Gland    176.2 Larval Trachea    114.5 Larval Carcass    103.875 Adult Head    56.7 Adult Eye    65.7 Adult Brain    125.4 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    71.4 Adult Midgut    66.3 Adult Hindgut    62.9 Adult Malpighian Tubules    34 Adult Fat Body    29.2 Adult Salivary Gland    93.8 Adult Heart    33.075 Adult VirginFemale Spermatheca    48.2 Adult InseminatedFemale Spermatheca    49 Adult Ovary    426.3 Adult Testis    152.8 Adult Male Accessory Gland    81.2 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    352.1 Larval Midgut    48.8 Larval Hindgut    71.5 Larval Malpighian Tubules    48.4 Larval Fat Body    100.4 Larval Salivary Gland    176.2 Larval Trachea    114.5 Larval Carcass    103.875 Adult Head    56.7 Adult Eye    65.7 Adult Brain    125.4 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    71.4 Adult Midgut    66.3 Adult Hindgut    62.9 Adult Malpighian Tubules    34 Adult Fat Body    29.2 Adult Salivary Gland    93.8 Adult Heart    33.075 Adult VirginFemale Spermatheca    48.2 Adult InseminatedFemale Spermatheca    49 Adult Ovary    426.3 Adult Testis    152.8 Adult Male Accessory Gland    81.2 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    352.1 Larval Midgut    48.8 Larval Hindgut    71.5 Larval Malpighian Tubules    48.4 Larval Fat Body    100.4 Larval Salivary Gland    176.2 Larval Trachea    114.5 Larval Carcass    103.875 Adult Head    56.7 Adult Eye    65.7 Adult Brain    125.4 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    71.4 Adult Midgut    66.3 Adult Hindgut    62.9 Adult Malpighian Tubules    34 Adult Fat Body    29.2 Adult Salivary Gland    93.8 Adult Heart    33.075 Adult VirginFemale Spermatheca    48.2 Adult InseminatedFemale Spermatheca    49 Adult Ovary    426.3 Adult Testis    152.8 Adult Male Accessory Gland    81.2 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    352.1 Larval Midgut    48.8 Larval Hindgut    71.5 Larval Malpighian Tubules    48.4 Larval Fat Body    100.4 Larval Salivary Gland    176.2 Larval Trachea    114.5 Larval Carcass    103.875 Adult Head    56.7 Adult Eye    65.7 Adult Brain    125.4 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    71.4 Adult Midgut    66.3 Adult Hindgut    62.9 Adult Malpighian Tubules    34 Adult Fat Body    29.2 Adult Salivary Gland    93.8 Adult Heart    33.075 Adult VirginFemale Spermatheca    48.2 Adult InseminatedFemale Spermatheca    49 Adult Ovary    426.3 Adult Testis    152.8 Adult Male Accessory Gland    81.2 Adult Carcass    50.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    352.1 Larval Midgut    48.8 Larval Hindgut    71.5 Larval Malpighian Tubules    48.4 Larval Fat Body    100.4 Larval Salivary Gland    176.2 Larval Trachea    114.5 Larval Carcass    103.875 Adult Head    56.7 Adult Eye    65.7 Adult Brain    125.4 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    71.4 Adult Midgut    66.3 Adult Hindgut    62.9 Adult Malpighian Tubules    34 Adult Fat Body    29.2 Adult Salivary Gland    93.8 Adult Heart    33.075 Adult VirginFemale Spermatheca    48.2 Adult InseminatedFemale Spermatheca    49 Adult Ovary    426.3 Adult Testis    152.8 Adult Male Accessory Gland    81.2 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    352.1 Larval Midgut    48.8 Larval Hindgut    71.5 Larval Malpighian Tubules    48.4 Larval Fat Body    100.4 Larval Salivary Gland    176.2 Larval Trachea    114.5 Larval Carcass    103.875 Adult Head    56.7 Adult Eye    65.7 Adult Brain    125.4 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    71.4 Adult Midgut    66.3 Adult Hindgut    62.9 Adult Malpighian Tubules    34 Adult Fat Body    29.2 Adult Salivary Gland    93.8 Adult Heart    33.075 Adult VirginFemale Spermatheca    48.2 Adult InseminatedFemale Spermatheca    49 Adult Ovary    426.3 Adult Testis    152.8 Adult Male Accessory Gland    81.2 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    352.1 Larval Midgut    48.8 Larval Hindgut    71.5 Larval Malpighian Tubules    48.4 Larval Fat Body    100.4 Larval Salivary Gland    176.2 Larval Trachea    114.5 Larval Carcass    103.875 Adult Head    56.7 Adult Eye    65.7 Adult Brain    125.4 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    71.4 Adult Midgut    66.3 Adult Hindgut    62.9 Adult Malpighian Tubules    34 Adult Fat Body    29.2 Adult Salivary Gland    93.8 Adult Heart    33.075 Adult VirginFemale Spermatheca    48.2 Adult InseminatedFemale Spermatheca    49 Adult Ovary    426.3 Adult Testis    152.8 Adult Male Accessory Gland    81.2 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    352.1 Larval Midgut    48.8 Larval Hindgut    71.5 Larval Malpighian Tubules    48.4 Larval Fat Body    100.4 Larval Salivary Gland    176.2 Larval Trachea    114.5 Larval Carcass    103.875 Adult Head    56.7 Adult Eye    65.7 Adult Brain    125.4 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    71.4 Adult Midgut    66.3 Adult Hindgut    62.9 Adult Malpighian Tubules    34 Adult Fat Body    29.2 Adult Salivary Gland    93.8 Adult Heart    33.075 Adult VirginFemale Spermatheca    48.2 Adult InseminatedFemale Spermatheca    49 Adult Ovary    426.3 Adult Testis    152.8 Adult Male Accessory Gland    81.2 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    56.7   NA  Eye    65.7   NA  Brain    125.4   352.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    115.8   NA  Crop    71.4   48.8  Midgut    66.3   71.5  Hindgut    62.9   48.4  Malpighian Tubules    34   100.4  Fat Body    29.2   176.2  Salivary Gland    93.8   NA  Heart    33.075   114.5  Trachea    NA   NA  VirginFemale Spermatheca    48.2   NA  InseminatedFemale Spermatheca    49   NA  Ovary    426.3   NA  Testis    152.8   NA  Male Accessory Gland    81.2   103.875  Carcass    50.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    28 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    58 ovary, mated 4-day female    56 testis, mated 4-day male    14 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (34) central nervous system, larvae L3  (28) central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female  (58) ovary, mated 4-day female  (56) testis, mated 4-day male    14 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    28 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    58 ovary, mated 4-day female    56 testis, mated 4-day male    14 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    28 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    58 ovary, mated 4-day female    56 testis, mated 4-day male    14 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    28 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    58 ovary, mated 4-day female    56 testis, mated 4-day male    14 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (34) central nervous system, larvae L3  28 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female  (58) ovary, mated 4-day female  (56) testis, mated 4-day male    14 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    28 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    58 ovary, mated 4-day female    56 testis, mated 4-day male    14 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    28 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    58 ovary, mated 4-day female    56 testis, mated 4-day male    14 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    95 embryo 02-04hr    114 embryo 04-06hr    88 embryo 06-08hr    61 embryo 08-10hr    42 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    16 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    9 embryo 22-24hr    7 larva L1    10 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    12 adult female 01day    32 adult female 05day    50 adult female 30day    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (95) embryo 02-04hr  (114) embryo 04-06hr  (88) embryo 06-08hr  (61) embryo 08-10hr  (42) embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    16 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    9 embryo 22-24hr    7 larva L1    10 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    12 adult female 01day  (32) adult female 05day  (50) adult female 30day  (54) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    95 embryo 02-04hr  (114) embryo 04-06hr    88 embryo 06-08hr    61 embryo 08-10hr    42 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    16 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    9 embryo 22-24hr    7 larva L1    10 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    12 adult female 01day    32 adult female 05day    50 adult female 30day    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    95 embryo 02-04hr    114 embryo 04-06hr    88 embryo 06-08hr    61 embryo 08-10hr    42 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    16 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    9 embryo 22-24hr    7 larva L1    10 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    12 adult female 01day    32 adult female 05day    50 adult female 30day    54 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    95 embryo 02-04hr    114 embryo 04-06hr    88 embryo 06-08hr    61 embryo 08-10hr    42 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    16 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    9 embryo 22-24hr    7 larva L1    10 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    12 adult female 01day    32 adult female 05day    50 adult female 30day    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (95) embryo 02-04hr  (114) embryo 04-06hr  (88) embryo 06-08hr  (61) embryo 08-10hr  (42) embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    16 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    9 embryo 22-24hr    7 larva L1    10 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    12 adult female 01day  32 adult female 05day  (50) adult female 30day  (54) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    95 embryo 02-04hr  114 embryo 04-06hr    88 embryo 06-08hr    61 embryo 08-10hr    42 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    16 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    9 embryo 22-24hr    7 larva L1    10 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    12 adult female 01day    32 adult female 05day    50 adult female 30day    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    95 embryo 02-04hr    114 embryo 04-06hr    88 embryo 06-08hr    61 embryo 08-10hr    42 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    16 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    9 embryo 22-24hr    7 larva L1    10 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    12 adult female 01day    32 adult female 05day    50 adult female 30day    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    16 embryonic 1182-4H    19 embryonic GM2    18 embryonic Kc167    14 embryonic S1    36 embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    6 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    28 ovary OSC    18 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (30) Schneider line 2 Sg4    16 embryonic 1182-4H    19 embryonic GM2    18 embryonic Kc167    14 embryonic S1  (36) embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    6 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1  26 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS  (28) ovary OSC    18 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    16 embryonic 1182-4H    19 embryonic GM2    18 embryonic Kc167    14 embryonic S1    36 embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    6 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    28 ovary OSC    18 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    16 embryonic 1182-4H    19 embryonic GM2    18 embryonic Kc167    14 embryonic S1    36 embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    6 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    28 ovary OSC    18 ovary OSS    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    16 embryonic 1182-4H    19 embryonic GM2    18 embryonic Kc167    14 embryonic S1    36 embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    6 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    28 ovary OSC    18 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  30 Schneider line 2 Sg4    16 embryonic 1182-4H    19 embryonic GM2    18 embryonic Kc167    14 embryonic S1  (36) embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    6 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1  26 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS  28 ovary OSC    18 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    16 embryonic 1182-4H    19 embryonic GM2    18 embryonic Kc167    14 embryonic S1    36 embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    6 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    28 ovary OSC    18 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    16 embryonic 1182-4H    19 embryonic GM2    18 embryonic Kc167    14 embryonic S1    36 embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    6 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    28 ovary OSC    18 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  (41) Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult  (27) Paraquat 10 mM 48 hrs, 4-day adult  (29) Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  (41) Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult  27 Paraquat 10 mM 48 hrs, 4-day adult  29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_13 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • RE64461 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0042085 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3274-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | female limited | recessive Bap170G5986 lethal | partially Bap170Δ65 lethal | prepupal stage (with Df(2R)hfl-37) Bap170hfl1 lethal | prepupal stage | recessive Bap170hfl1 Bap170Δ135 lethal | pupal stage | recessive Bap170Δ115 Bap170Δ135 partially lethal - majority die | adult stage, with Scer\GAL4pnr-MD237 Bap170GD10922 partially lethal - majority die | male limited | recessive Bap170G5986 Sterility Allele fertile Bap170Δ65 Other Phenotypes Allele visible Bap170Δ65 visible, with Scer\GAL4pnr-MD237 Bap170GD10922 visible, with Scer\GAL4salm-459.2 Bap170GD10922 visible, with Scer\GAL4T80 Bap170dsRNA.Scer\UAS.cRa visible (with Bap170C1.Scer\UAS), with Scer\GAL4Dll-md23 Bap170hfl1 visible (with Bap170hfl1), with Scer\GAL4Dll-md23 Bap170C1.Scer\UAS Phenotype manifest in Allele cone cell | supernumerary (with Bap170C1.Scer\UAS), with Scer\GAL4Dll-md23 Bap170hfl1 cone cell | supernumerary (with Bap170hfl1), with Scer\GAL4Dll-md23 Bap170C1.Scer\UAS eye photoreceptor cell | supernumerary (with Bap170C1.Scer\UAS), with Scer\GAL4Dll-md23 Bap170hfl1 eye photoreceptor cell | supernumerary (with Bap170hfl1), with Scer\GAL4Dll-md23 Bap170C1.Scer\UAS imaginal disc | prepupal stage Bap170hfl1 Bap170Δ135 leg Bap170G5986 mesothoracic tergum, with Scer\GAL4pnr-MD237 Bap170GD10922 outer photoreceptor cell | supernumerary (with Bap170C1.Scer\UAS), with Scer\GAL4Dll-md23 Bap170hfl1 outer photoreceptor cell | supernumerary (with Bap170hfl1), with Scer\GAL4Dll-md23 Bap170C1.Scer\UAS photoreceptor cell R7 | supernumerary (with Bap170C1.Scer\UAS), with Scer\GAL4Dll-md23 Bap170hfl1 photoreceptor cell R7 | supernumerary (with Bap170hfl1), with Scer\GAL4Dll-md23 Bap170C1.Scer\UAS wing hair | ectopic, with Scer\GAL4salm-459.2 Bap170GD10922 wing margin, with Scer\GAL4salm-459.2 Bap170GD10922 wing sensillum | ectopic, with Scer\GAL4salm-459.2 Bap170GD10922 wing vein, with Scer\GAL4salm-459.2 Bap170GD10922 wing vein | ectopic Bap170Δ65 wing vein | ectopic, with Scer\GAL4T80 Bap170dsRNA.Scer\UAS.cRa
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Bap170 Class Mutagen Stocks Known lesion Bap170G5986 P-element activity 1 Yes Bap170GS4009 1 -- Bap170hfl1 P-element activity 0 Yes Bap170Δ115 Delta2-3 0 Yes Bap170Δ135 Delta2-3 0 Yes Bap170Δ65 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Bap170 Class Mutagen Stocks Known lesion Bap170GD10922 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Bap170JF02080 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Bap170+Ra in vitro construct - genomic fragment 0 Yes Bap1701.3.T:Ecol\lacZ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Bap170C1.Scer\UAS in vitro construct - regulatory fusion 0 Yes Bap170C2.Scer\UAS in vitro construct - regulatory fusion 0 Yes Bap170dsRNA.Scer\UAS.cRa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Bap170dsRNA.Scer\UAS.WIZ in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Bap170NIG.3274R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Bap170Scer\UAS.cCa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)Drlrv17 (Rendina et al., 2010) Df(2R)nap1 (Rendina et al., 2010)
Disrupted in	Df(2R)hfl-37 (Rendina et al., 2010, Rendina et al., 2010, Rendina et al., 2010, Rendina et al., 2010) Df(2R)ST1 (Rendina et al., 2010)
Partially disrupted in	Df(2R)Bap170Δ115 (Carrera et al., 2008) Df(2R)Bap170Δ135 (Carrera et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10922} NA P{NIG.3274R} NA P{TRiP.JF02080} NA P{UAS-Bap170.C1} NA P{UAS-Bap170.C2} NA P{UAS-Bap170.C} NA P{UAS-Bap170.RNAi} NA P{UAS-Bap170.WIZ} NA reporter construct P{Bap170-lacZ.1.3} No
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Bap170G5986 NA P{GSV1}Vha16-1GS4009 NA miscellaneous insertions P{?EPgy2}Bap170Δ135 NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with z (Kal et al., 2000)
Biological Process
CV term Evidence References
imaginal disc-derived leg morphogenesis inferred from genetic interaction with e(y)3, polybromo (Chalkley et al., 2008) inferred from genetic interaction with polybromo (Chalkley et al., 2008) inferred from mutant phenotype (Chalkley et al., 2008) imaginal disc-derived wing margin morphogenesis inferred from mutant phenotype (Terriente-Félix and de Celis, 2009) imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Terriente-Félix and de Celis, 2009) negative regulation of chromatin silencing inferred from genetic interaction with Pc, polybromo (Chalkley et al., 2008) negative regulation of epidermal growth factor receptor signaling pathway inferred from genetic interaction with bs (Rendina et al., 2010) inferred from genetic interaction with Egfr (Rendina et al., 2010) inferred from genetic interaction with phl (Rendina et al., 2010) inferred from genetic interaction with pnt (Rendina et al., 2010) inferred from genetic interaction with Ras85D (Rendina et al., 2010) inferred from genetic interaction with vn (Rendina et al., 2010) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) positive regulation of transcription, DNA-dependent inferred from direct assay (Kal et al., 2000) protein stabilization inferred from mutant phenotype (Carrera et al., 2008)
Cellular Component
CV term Evidence References
brahma complex inferred from direct assay (Kal et al., 2000) polytene chromosome inferred from direct assay (Chalkley et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR001606 (FlyBase Curators et al., 2004-) contributes_to transcription coactivator activity inferred by curator from GO:0035060 (Kal et al., 2000)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Bap170 - ssp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Bap170 allele Gene References unspecified ct (Krupp et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61460 DroID - A comprehensive database of gene and protein interactions. • FBgn0042085 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35560
Orthologs
OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG68KRWH Dipteran inclusive ortholog search EOG6NS3KX Insect inclusive ortholog search EOG60VTJW Arthropod inclusive ortholog search EOG6XD25X Metazoa inclusive ortholog search EOG6NKQNC
Orthologs in Drosophila Species (EOG68KRWH)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Bap170     Drosophila simulans   Dsim\GD10411 Y   Drosophila sechellia   Dsec\GM20880 Y   Drosophila erecta   Dere\GG23207 Y   Drosophila yakuba   Dyak\GE19061 Y   Drosophila ananassae   Dana\GF11056 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17110 Y   Drosophila persimilis   Dper\GL20250     Drosophila willistoni   Dwil\GK19622 Y   Drosophila virilis   Dvir\GJ21457 Y   Drosophila mojavensis   Dmoj\GI18380 Y   Drosophila grimshawi   Dgri\GH22895 Y
Orthologs in non-Drosophila Dipterans (EOG6NS3KX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001361   Anopheles gambiae Malaria mosquito  Agam\AGAP006990   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002241
Orthologs in non-Dipteran Insects (EOG60VTJW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Pogonomyrmex barbatus Red harvester ant  Pbar\PB12588   Bombyx mori Silkmoth  Bmor\BGIBMGA009297
Orthologs in non-Insect Arthropods (EOG6XD25X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ORF1   Ixodes scapularis Deer tick  Isca\ISCW002479   Ixodes scapularis Deer tick  Isca\ISCW014107   Ixodes scapularis Deer tick  Isca\ISCW014110
Orthologs in non-Arthropod Metazoa (EOG6NKQNC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C08B11.3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020287gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020286gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026159gn   Danio rerio Zebrafish  Drer\arid2   Xenopus tropicalis Western clawed frog  Xtro\arid2   Gallus gallus Domestic chicken  Ggal\ARID2   Mus musculus House mouse  Mmus\Arid2   Rattus norvegicus Norway rat  Rnor\Arid2   Homo sapiens Human  Hsap\ARID2
Human Orthologs (1)
Gene OMIM HGNC Hsap\ARID2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10411 Drosophila sechellia Dsec\GM20880 Drosophila erecta Dere\GG23207 Drosophila yakuba Dyak\GE19061 Drosophila ananassae Dana\GF11056 Drosophila pseudoobscura pseudoobscura Dpse\GA17110 Drosophila persimilis Dper\GL20261 Drosophila willistoni Dwil\GK19622 Drosophila virilis Dvir\GJ21457 Drosophila mojavensis Dmoj\GI18380 Drosophila grimshawi Dgri\GH22895
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	26308 y1 v1; P{TRiP.JF02080}attP2 28471 y1 w*; P{EP}Bap170G5986/CyO
Kyoto	200625 y1 w67c23; P{GSV1}Vha16-1GS4009/SM1
VDRC	v34581 w1118 P{GD10922}v34581 v34582 w1118; P{GD10922}v34582/TM3
Genomic Clones ( 1 )
	BACR01C10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 112 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH12174 RE64461
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01992 AT19758 GH04410 GH07129 GH18239 GM30166 LD01636 RE10221 RE33012 RE53710 SD04290 SD16710 SD20203 SD21679 SD26413 SD27615
Other clones	14745 35094 44214 118068 148098 149742 211276.2 214507.56 556952 CK01.22D.E8 CK01.56A.C10 Dmel_dig_020757_0706_3627 EC24858 EC34358 EC051329 EC052239 EC053736 EC053823 EC054696 EC056548 EK159562 EK255837 EN11742 EP18246 GH22065 RP003047840 RP003065300 RP003065992 RP003066415 RP003077368 RP003096596 RP003100631 RP003105427 RP003107982 RP003108549 RP003111157 RP003113324 RP003141460 RP003181672 RP003182143 RP003197207 RP003200335 RP003216937 RP003238638 RP003243636 RP003245597 RP003262649 RP003268161 RP003272644 RP003274537 RP003277010 RP003277602 RP003278125 RP003280829 RP003284677 RP003286886 RP003307575 RP003308991 RP003310905 RP003317046 RP003331061 RP003341608 RP003354246 RP003366974 RP003407524 RP003417937 RP003429791 RP003430648 RP003439522 RP003440558 RP003447849 RP003451402 RP003452462 RP003467100 RP003479698 RP003480990 RP003499197 RP003510973 RP003513369 RP003531199 RP003549615 RP003551828 RP003559584 RP003564158 RP003569932 RP003571307 RP003572301 RP003573740 RP003600337 RP003614348 RP003651747 RP003674537 SD02491 UUGC0531
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0042085 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35560
Antibody Information
	polyclonal (Chalkley et al., 2008, Carrera et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Bap170 CG3274 (Carrera, 2005.3.2)
Source for database merge of
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) D.melanogaster contains two distinct brahma (BRM) complexes: the BAP complex, defined by the presence of osa protein and the absence of both polybromo and Bap170 proteins, and the PBAP complex, which contains the polybromo and Bap170 proteins but lacks the osa protein. (Mohrmann et al., 2004) Identification: as a protein from embryo nuclear extracts that copurifies with brm protein. (Kal et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136372 RefSeq (Proteins) • NP_610216 DDBJ / EMBL / GenBank • AAD38647 AAF57363 AF145672 AFH07903 AI134652 AI402282 BI481854 Entrez Gene - A searchable database of RefSeq genes. • 35560 UniProtKB/TrEMBL • A1Z6M0 Q7KMJ0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ARID/BRIGHT DNA-binding domain (IPR001606) DNA-binding RFX-type winged-helix domain (IPR003150) Zinc finger, C2H2-like (IPR015880) Winged helix-turn-helix DNA-binding domain (IPR011991) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE64461
Linkouts
	BioGRID - A database of protein and genetic interactions • 61460 DroID - A comprehensive database of gene and protein interactions. • FBgn0042085 DRSC - Results from RNAi screens. • FBgn0042085 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0042085 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3274-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0042085 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35560 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35560 modMine - Data generated by the modENCODE project. • FBgn0042085
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	BAP170 (Krupp et al., 2005, Mohrmann et al., 2004, Eberharter and Becker, 2004, Kal et al., 2000, Moshkin et al., 2007, Vorobyeva et al., 2009, Nakamura et al., 2008, Vorobyeva et al., 2009, Soshnikova et al., 2008, Vorobyeva et al., 2008) Bap170 (Rendina et al., 2010, Curtis et al., 2011, Lee et al., 2008, Waldholm et al., 2011, Costa et al., 2013, Mourikis et al., 2010, Di Stefano et al., 2011, Japanese National Institute of Genetics, 2012.5.21) bap170 (Chalkley et al., 2008, Carrera et al., 2008, Terriente-Félix and de Celis, 2009, Rendina et al., 2010) BcDNA:GH12174 (Giot et al., 2003, ) CG3274 (Mohrmann et al., 2004, Laviolette et al., 2005, Stroschein-Stevenson et al., 2006, Perkins et al., 2009.3.31) hfl (Rendina et al., 2010)
Name Synonym	Brahma associated protein 170kD (Kal et al., 2000) half-life (Rendina et al., 2010)
Secondary FlyBase IDs
	FBgn0027541
References ( 41 )
Generate a list of	All references relating to this gene ( 41 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Costa et al., 2013, Cell Death Dis. 4: e467 Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease. [FBrf0220561] Curtis et al., 2011, Dev. Biol. 350(2): 534--547 Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development. [FBrf0212876] Di Stefano et al., 2011, Genes Dev. 25(1): 17--28 Functional antagonism between histone H3K4 demethylases in vivo. [FBrf0212709] Waldholm et al., 2011, BMC Mol. Biol. 12: 46 SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster. [FBrf0216757] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...