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FB2026_01
,
released March 12, 2026
LRP, LRP6, LRP5/6, CT15575, l(2)k08131
LDL-receptor-related protein (LRP) family - a type I trans-membrane protein and functions as an obligate co-receptor with Frizzled for Wingless in the canonical Wnt signaling pathway - binds Axins and consequently induces LEF-1 activation by destabilizing Axin and stabilizing ß-catenin
Please see the JBrowse view of Dmel\arr for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\arr using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: seen in motor neurons synapsing on A1-7 ventral longitudinal muscle 1-2 (muscle 12-13)
JBrowse - Visual display of RNA-Seq signals
View Dmel\arr in JBrowse
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Reducing arr expression, specifically in adult mushroom bodies, impairs long-term memory expression without altering other temporally or mechanistically distinct forms of olfactory memory.
dsRNA made from templates generated with primers directed against this gene.
Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.
Mutations in arr disrupt midgut morphogenesis and nervous system development. Failure of somatic arr- clones to grow to normal size strongly suggests that arr is essential for cell viability or proliferation or both. Germline clonal analysis reveals arr is required for germline proliferation and oocyte development.
Deficiency homozygotes for arr fail to complete embryogenesis: the second midgut constriction and the gastric caecae are missing, and axonal extension also shows defects.
Mutant alleles are embryonic lethal with extra denticle bands, especially on ventral midline.
Source for merge of: LRP6 CG5912
Source for merge of: arr LRP6
Source for merge of: arr BEST:CK00539
FlyBase curator comment: the insertion in the "e00083" Exelixis line (PBac{RB}CG5970e00083) was originally assigned to the arr gene in FBrf0179797, resulting in the "arre00083" (FBal0159480) allele. However, FBrf0184340 shows that the insertion is actually within CG5970.
