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FB2026_01
,
released March 12, 2026
E75, E75A, E75B, E75C, l(3)neo25
nuclear receptor - ensures proper temporal progression of larval development - nitric oxide coordinates metabolism, growth, and development via E75
Please see the JBrowse view of Dmel\Eip75B for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 6.02
6, 5.7, 5.2, 4.9 (northern blot)
1394, 1237 (aa); 151, 132 (kD predicted)
One of a couple of protein products.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Eip75B using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: from -12 hr APF
Comment: maternally deposited
Comment: reference states 4 hours before puparium formation
Expression increases after the late larval (-4 hr APF) and prepupal (+10 hr APF) ecdysone pulses.
Expression of Eip75B coincides with a pulse of ecdysone shortly before puparium formation, and a second wave at 10 hours after pupation.
Eip75B protein expression is upregulated in the ring gland very late in larval development; expression is detected mostly in the corpus cardiacum at "blue gut" stage, but detectable thoughout the entire ring gland at "cleared gut" stage.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Eip75B in JBrowse
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Mutations affecting isoform A cause a reduced ecdysteroid titer during larval development, resulting in developmental delays, developmental arrests, and molting defects. These defects are rescuable by ecdysone treatment.
Ecdysteroid-induced Eip75B expression amplifies or maintains ecdysteroid titer during larval development, ensuring proper temporal progression through the life cycle.
One of a class of genes with TATA-less promoters that have a subset of the conserved DPE sequence.
A fragment of a Eip75B cDNA has been used to clone a homologous gene from the wax moth Galleria mellonella.
Ecdysteroid-regulated gene.
Eip75B protein binds to discrete sites on polytene chromosomes, correlating with early and late ecdysone-induced puffs.
Random cDNAs from subtracted libraries subjected to a rapid and sensitive screen for their ability to detect mRNAs induced by ecdysone in the presence of cycloheximide identified the ecdysone inducible gene Eip75B.
Encodes an ecdysone-inducible gene associated with the early puff at polytene position 75B. Periodic expression occurs in response to ecdysone pulses occurring at specific times during development; regression of puff and reduction of Eip75B expression in third instar does not occur in the presence of cycloheximide, and presumably depends on ecdysone-induced gene products.
Eip75B encodes two proteins that contain sequences homologous to the DNA-binding and hormone-binding domains of proteins in the steroid receptor superfamily.
Source for merge of: Eip75B l(3)neo25
Source for merge of: Eip75B BcDNA:GM02640
Source for merge of: Eip75B anon-WO0172774.31 anon-WO0172774.32
Source for merge of Eip75B BcDNA:GM02640 was a shared cDNA ( date:030728 ).
Source for merge of Eip75B anon-WO0172774.31 anon-WO0172774.32 was sequence comparison ( date:051113 ).
