Gene Group: METALLOPEPTIDASES

General Information

Name

METALLOPEPTIDASES

Species

D. melanogaster

Symbol

MPEPT

FlyBase ID

FBgg0001400

Date last reviewed

2020-06-08

Number of members

119

Description

Metallopeptidases catalyse the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Notes on Group

Source Material

The METALLOPEPTIDASES Gene Group has been compiled using the following publication(s): Li et al., 2022, Páhi et al., 2022, Badmos et al., 2021, Meyer et al., 2021, Andreyeva et al., 2019, Laurinyecz et al., 2019, Meyer et al., 2018.7.18, LaFever et al., 2017, Tang et al., 2017, Kim et al., 2016, Small and Crawford, 2016, Delabaere et al., 2014, Sitnik et al., 2014, Clague et al., 2013, Ismat et al., 2013, Adolphsen et al., 2012, Tsou et al., 2012, Zhang et al., 2012, Dorus et al., 2011, Meyer et al., 2011, Bland et al., 2008, Wei et al., 2008, Nicholson et al., 2005, Doronkin et al., 2003, Mazzocco et al., 2003, Cope et al., 2002, Schulz et al., 2001, Coates et al., 2000, Giglione et al., 2000, Juhola et al., 2000, and Rawlings and Barrett, 1996- .

Key Gene Ontology (GO) terms

Molecular Function

metallopeptidase activity

Biological Process

proteolysis

Cellular Component

Related Gene Groups

Parent group(s)

PEPTIDASES

Members (119)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

ADAM METALLOPROTEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Kul

Kuzbanian-like

ADAM10

(FlyBase, 2017-, Meyer et al., 2011, Rawlings and Barrett, 1996-)

kuz

kuzbanian

l(2)34Da, l(2)br38, BG:DS07660.3

(FlyBase, 2017-, Meyer et al., 2011, Rawlings and Barrett, 1996-)

Meltrin

Neu3, DMeltrin, CT23341

(FlyBase, 2017-, Meyer et al., 2011, Rawlings and Barrett, 1996-)

Tace

(FlyBase, 2017-, Meyer et al., 2011, Rawlings and Barrett, 1996-)

ADAM WITH THROMBOSPONDIN MOTIF

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

AdamTS-A

ADAM metallopeptidase with thrombospondin type 1 motif A

l(3)89Aa

(FlyBase, 2017-, Kim et al., 2016, Ismat et al., 2013, Meyer et al., 2011, Nicholson et al., 2005, Rawlings and Barrett, 1996-)

AdamTS-B

ADAM metallopeptidase with thrombospondin type 1 motif B

(FlyBase, 2017-, Kim et al., 2016, Ismat et al., 2013, Meyer et al., 2011, Nicholson et al., 2005, Rawlings and Barrett, 1996-)

sona

sol narae

Dimp

(FlyBase, 2017-, Kim et al., 2016, Meyer et al., 2011, Rawlings and Barrett, 1996-)

stl

stall

fs(2)A16

(FlyBase, 2017-, Kim et al., 2016, Ismat et al., 2013, Meyer et al., 2011, Rawlings and Barrett, 1996-)

ANGIOTENSIN-CONVERTING ENZYME-LIKE PEPTIDYL-DIPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Acer

Angiotensin-converting enzyme-related

l(2)k07704

(FlyBase, 2017-, Coates et al., 2000, Rawlings and Barrett, 1996-)

Ance

Angiotensin converting enzyme

Race, ACE, BG:DS08220.3

(FlyBase, 2017-, Coates et al., 2000, Rawlings and Barrett, 1996-)

ASTACINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5715

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG6696

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG6763

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG6974

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG7631

BG:BACR44L22.6

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG10280

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG11865

BG:BACR44L22.4

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG15253

BG:BACR44L22.3

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG15254

BG:BACR44L22.2

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG15255

BG:BACR44L22.1

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Semp1

Seminal metalloprotease-1

BG:BACR44L22.8

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

tld

tolloid

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

tok

tolkin

tlr, tolloid-related 1, tlr-1, tldr-1, tolloid-related

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

ATP-DEPENDENT METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Afg3l2

AFG3 like matrix AAA peptidase subunit 2

(FlyBase, 2017-, Juhola et al., 2000, Rawlings and Barrett, 1996-)

Spg7

Paraplegin

anon-3Ba, EG:100G10.7

(FlyBase, 2017-, Juhola et al., 2000, Rawlings and Barrett, 1996-)

YME1L

YME1 like ATPase

dYME1L

(FlyBase, 2017-, Juhola et al., 2000, Rawlings and Barrett, 1996-)

JAMM DEUBIQUITINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2224

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

CG4751

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012)

eIF3f1

eukaryotic translation initiation factor 3 subunit f1

eIF3-S5

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

eIF3f2

eukaryotic translation initiation factor 3 subunit f2

eIF3f

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Zhang et al., 2012, Rawlings and Barrett, 1996-)

eIF3h

eukaryotic translation initiation factor 3 subunit h

eIF-3p40, l(2)k09003, Eukaryotic initiation factor 3 p40 subunit

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Rpn11

Regulatory particle non-ATPase 11

p37B, 37B, S13, DmS13

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

LEUCYL AMINOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Dip-B

Dipeptidase B

DipB

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

grsm

granny smith

BcDNA:LD41548

(Laurinyecz et al., 2019, FlyBase, 2017-, Dorus et al., 2011, Rawlings and Barrett, 1996-)

M1 METALLOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3502

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG5849

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG7653

BG:DS00365.1

(Li et al., 2022, FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8773

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG8774

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG10602

(FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG11951

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG31198

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG31233

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG31343

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG31445

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG32473

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG42335

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG46339

sda, slamdance

(Li et al., 2022, FlyBase, 2017-, Rawlings and Barrett, 1996-)

Psa

Puromycin sensitive aminopeptidase

dPsa, l(3)06226

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

SP1029

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

superdeath

Suppressor of ER stress-induced death

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

M3 METALLOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG7791

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M8 METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Invadolysin

l(3)IX-14, IX-14

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M14 METALLOCARBOXYPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2915

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG3097

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG3108

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG4017

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG4408

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG4678

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG7025

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8539

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8560

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8562

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8563

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8564

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG12374

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG14820

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG17633

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG18417

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG18585

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG31019

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG32379

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Nna1

Nna1 carboxypeptidase

NnaD

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

svr

silver

EG:171D11.3, CPD, slv

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M16 METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3107

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8728

(FlyBase, 2017-)

CG10588

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Ide

Insulin degrading metalloproteinase

dIDE

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Nrd1

Nardilysin

dNRD1

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

UQCR-C1

Ubiquinol-cytochrome c reductase core protein 1

(Rawlings and Barrett, 1996-)

M19 METALLODIPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6154

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG42750

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG44837

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M20 METALLOEXOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cndp2

Cytosolic non-specific dipeptidase 2

Dip-A, anon-41Fb

(Andreyeva et al., 2019, FlyBase, 2017-, Rawlings and Barrett, 1996-)

M24B METALLOEXOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

ApepP

Aminopeptidase P

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG9581

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Dip-C

Dipeptidase C

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M28 METALLOEXOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG9416

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG10051

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG10062

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG10073

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG10081

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG11961

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG13160

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG30043

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG30047

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG30049

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG33012

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M49 METALLODIPEPTIDYL-PEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

DppIII

Dipeptidyl aminopeptidase III

Dipeptidyl-peptidase III

(FlyBase, 2017-, Mazzocco et al., 2003, Rawlings and Barrett, 1996-)

M76 METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5131

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M79 METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Sras

severas

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M100 METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

maternal haploid

fs(1)1182, fs(1)A1182

(FlyBase, 2017-, Tang et al., 2017, Delabaere et al., 2014)

MATRIX METALLOPROTEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Mmp1

Matrix metalloproteinase 1

MMP-1, dMMP1, Dm1-MMP, matrix metalloprotease 1, l(2)k04809

(FlyBase, 2017-, LaFever et al., 2017, Small and Crawford, 2016, Meyer et al., 2011, Rawlings and Barrett, 1996-)

Mmp2

Matrix metalloproteinase 2

l(2)02353, dmmp2, Dm2-MMP

(FlyBase, 2017-, LaFever et al., 2017, Small and Crawford, 2016, Meyer et al., 2011, Rawlings and Barrett, 1996-)

METALLO-TYPE DENEDDYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CSN5

COP9 signalosome subunit 5

DCH5, l(3)L4032, Jab1, l(3)89Cf, jab1/csn5

(FlyBase, 2017-, Wei et al., 2008, Doronkin et al., 2003, Cope et al., 2002, Rawlings and Barrett, 1996-)

METHIONYL AMINOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5188

(FlyBase, 2017-, Giglione et al., 2000, Rawlings and Barrett, 1996-)

CG13630

(FlyBase, 2017-, Giglione et al., 2000, Rawlings and Barrett, 1996-)

und

uninitiated

p67

(FlyBase, 2017-, Giglione et al., 2000, Rawlings and Barrett, 1996-)

NEPRILYSINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Nep1

Neprilysin 1

dNEP1

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nep2

Neprilysin 2

dNEP2

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nep3

Neprilysin 3

dNEP3

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nep4

Neprilysin 4

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nep5

Neprilysin 5

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nep6

Neprilysin 6

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nep7

Neprilysin 7

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

SITE 2 PEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

S2P