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FB2026_01
,
released March 12, 2026
Kr-h, Kruppel homolog 1, Pow, Passion of white, l(2)10642
zinc finger transcription factor - mediates some of the juvenile hormone signaling in the adult abdominal epidermis and is upstream of broad in this pathway
Please see the JBrowse view of Dmel\Kr-h1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.54
4.5, 3.8, 3.2 (northern blot)
3.8 (longest cDNA)
The 3.8 kb Kr-h1 transcript is present at low levels in 0-4 hr embryos and at high levels in mid-embryogenesis. Levels subsequently decline.
Low levels of the 4.5 kb Kr-h1 transcripts are present in mid-embryogenesis and also in first instar larvae. Expression levels become significant starting at second larval instar and continue through 6-8 hours after pupariation. The transcript is also present in adult flies.
The largest Kr-h1 transcript is detected in embryos.
None of the polypeptides share 100% sequence identity.
845, 791 (aa)
The eight zinc finger domains of Kr-h1 protein are preceded by a glutamine-rich domain and followed by a serine-threonine rich domain, both of which are characteristic of transcription factors.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Kr-h1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as posterior spiracle specific anlage
Comment: 2-4 hr AEL
Comment: 8-24 hr AEL
Comment: reference states 0-24 hr AEL
Comment: reference states <=6-8 hr APF
Comment: reference states 6-8 hr APF
Kr-h1 expression is high in the prothoracic gland in larvae.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Kr-h1 in JBrowse2-18
2-19.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Ortholog of B. mori juvenile-hormone-related gene (involved in JH biosynthesis, metabolism or signaling).
Kr-h1 acts as a modulator of the expression of many ecdysone regulated genes during metamorphosis.
A 4.5kb transcript of Kr-h1 is indispensable for normal progression of metamorphosis.
Identified as a dosage sensitive modifier of w allele expression.
A dosage sensitive regulator of w gene expression.
Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.
Source for merge of: Kr-h1 Pow
Source for merge of: Kr-h1 CG18783
Annotation CG18783 split into CG45074 (Kr-h1) and CG45075 in release 5.54 of the genome annotation. Split based on cDNA, EST and RNA-Seq data.
One or more of the processed transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG45074 (Kr-h1) and CG45075.
Source for merge of Kr-h1 CG18783 was a shared cDNA ( date:010720 ).
The original gene name "Kruppel homolog 1" (Kr-h1) was changed to "Kr transcription factor homolog 1" (Kr-h1) to eliminate the potentially offensive association of "Kruppel" with human conditions.
