FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Ptp61F
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General Information
Symbol
Dmel\Ptp61F
Species
D. melanogaster
Name
Protein tyrosine phosphatase 61F
Annotation Symbol
CG9181
Feature Type
protein_coding_gene
FlyBase ID
FBgn0267487
Gene Model Status
Current
Stock Availability
34 publicly available
Enzyme Name (EC)
protein-tyrosine-phosphatase (3.1.3.48)
Gene Summary
Protein tyrosine phosphatase 61F (Ptp61F) encodes a non-receptor protein tyrosine phosphatase. It is known to act as a negative regulator of various kinase-dependent signalling pathways, including the JAK-STAT, Insulin-like Receptor, EGFR, and Pvr pathways in a wide variety of contexts. [Date last reviewed: 2022-01-20] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DPTP61F, protein tyrosine phosphatase

Key Links
Genomic Location
Cytogenetic map
61F7-62A2
Sequence location
Recombination map
3-0.5
RefSeq locus
NT_037436 REGION:1342493..1475257
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (27 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables non-membrane spanning protein tyrosine phosphatase activity
inferred from direct assay
(Chen et al., 2012)
enables protein binding
inferred from physical interaction with FLYBASE:Abi; FB:FBgn0020510
(Huang et al., 2007)
enables protein sequestering activity
inferred from physical interaction with FLYBASE:ex; FB:FBgn0004583,FLYBASE:yki; FB:FBgn0034970
(Liu et al., 2022)
enables protein tyrosine phosphatase activity
inferred from genetic interaction with FLYBASE:Stat92E; FB:FBgn0016917
(Willoughby et al., 2017)
inferred from mutant phenotype
(Buszard et al., 2013, Huang et al., 2007)
inferred from direct assay
(Wu et al., 2011, McLaughlin and Dixon, 1993)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables non-membrane spanning protein tyrosine phosphatase activity
inferred from biological aspect of ancestor with PANTHER:PTN001057235
(GO Reference Genome Project, 2011-)
enables protein kinase binding
inferred from biological aspect of ancestor with PANTHER:PTN001057235
(GO Reference Genome Project, 2011-)
enables protein tyrosine phosphatase activity
inferred from electronic annotation with InterPro:IPR000242
(InterPro Project Members, 2004-)
Biological Process (18 terms)
Terms Based on Experimental Evidence (18 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from physical interaction with FLYBASE:dock; FB:FBgn0010583
(Clemens et al., 1996)
involved_in cellular response to hypoxia
inferred from mutant phenotype
(Lee et al., 2008)
involved_in cellular response to mechanical stimulus
inferred from mutant phenotype
(Liu et al., 2022)
involved_in germ-band extension
inferred from direct assay
(Ursuliak et al., 1997)
involved_in mitotic cell cycle
inferred from mutant phenotype
(Chen et al., 2007)
involved_in negative regulation of cell population proliferation
inferred from mutant phenotype
(Liu et al., 2022, Buszard et al., 2013)
involved_in negative regulation of epidermal growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
(Willoughby et al., 2017, Tchankouo-Nguetcheu et al., 2014)
involved_in negative regulation of ERK1 and ERK2 cascade
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
(Willoughby et al., 2017)
inferred from genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205
(Tchankouo-Nguetcheu et al., 2014)
inferred from genetic interaction with FLYBASE:rl; FB:FBgn0003256
(Tchankouo-Nguetcheu et al., 2014)
involved_in negative regulation of insulin receptor signaling pathway
inferred from mutant phenotype
(Saedi et al., 2024, Gao et al., 2000)
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Tchankouo-Nguetcheu et al., 2014, Buszard et al., 2013, Wu et al., 2011)
inferred from genetic interaction with FLYBASE:dock; FB:FBgn0010583
(Willoughby et al., 2017)
involved_in negative regulation of JNK cascade
inferred from genetic interaction with FLYBASE:Pvf2; FB:FBgn0031888
(Willoughby et al., 2017)
involved_in negative regulation of organ growth
inferred from mutant phenotype
(Liu et al., 2022)
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferred from genetic interaction with FLYBASE:Akt; FB:FBgn0010379
(Tchankouo-Nguetcheu et al., 2014)
inferred from genetic interaction with FLYBASE:Pi3K92E; FB:FBgn0015279
(Tchankouo-Nguetcheu et al., 2014)
involved_in negative regulation of receptor signaling pathway via JAK-STAT
inferred from genetic interaction with FLYBASE:hop; FB:FBgn0004864
(Baeg et al., 2005)
inferred from genetic interaction with FLYBASE:CG5953; FB:FBgn0032587
(Hu et al., 2025)
inferred from mutant phenotype
(Jaiswal et al., 2023, Willoughby et al., 2017, Buszard et al., 2013, Muller et al., 2005)
inferred from genetic interaction with FLYBASE:Stat92E; FB:FBgn0016917
(Saadin and Starz-Gaiano, 2016)
involved_in negative regulation of TORC1 signaling
inferred from mutant phenotype
(Liu et al., 2022)
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Pvf2; FB:FBgn0031888
(Willoughby et al., 2017)
involved_in positive regulation of hippo signaling
inferred from mutant phenotype
(Liu et al., 2022)
involved_in regulation of protein localization
inferred from direct assay
(Huang et al., 2007)
involved_in regulation of protein stability
inferred from mutant phenotype
(Huang et al., 2007)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in negative regulation of ERK1 and ERK2 cascade
inferred from biological aspect of ancestor with PANTHER:PTN001057235
(GO Reference Genome Project, 2011-)
involved_in negative regulation of receptor signaling pathway via JAK-STAT
inferred from biological aspect of ancestor with PANTHER:PTN001057235
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(McLaughlin and Dixon, 1993)
located_in mitochondrial envelope
inferred from direct assay
(McLaughlin and Dixon, 1993)
is_active_in nucleus
inferred from direct assay
(Hu et al., 2025)
located_in nucleus
inferred from direct assay
(McLaughlin and Dixon, 1993)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Huang et al., 2007)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN001057235
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001057235
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. (Q9W0G1)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
protein tyrosine phosphatase activity
O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate (3.1.3.48)
RHEA 10684:
Summaries
Gene Snapshot
Protein tyrosine phosphatase 61F (Ptp61F) encodes a non-receptor protein tyrosine phosphatase. It is known to act as a negative regulator of various kinase-dependent signalling pathways, including the JAK-STAT, Insulin-like Receptor, EGFR, and Pvr pathways in a wide variety of contexts. [Date last reviewed: 2022-01-20]
Gene Group (FlyBase)
CYTOSOLIC PROTEIN TYROSINE PHOSPHATASES -
Cytosolic Protein Tyrosine Phosphatases are non-receptor tyrosine phosphatases. The Protein Tyrosine Phosphatases are defined by the active-site signature motif Cys-X5-Arg. (Adapted from FBrf0129980 and PMID:17057753).
Pathway (FlyBase)
NEGATIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY -
Negative regulators of JAK-STAT signaling down-regulate the pathway, attenuating transcriptional control by Stat92E.
NEGATIVE REGULATORS OF INSULIN-LIKE RECEPTOR SIGNALING PATHWAY -
Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
POSITIVE REGULATORS OF HIPPO SIGNALING PATHWAY -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of yki, negatively regulating tissue growth (Adapted from FBrf0224870).
NEGATIVE REGULATORS OF EGFR SIGNALING PATHWAY -
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
NEGATIVE REGULATORS OF PVR SIGNALING PATHWAY -
Negative regulators of Platelet-derived Growth Factor-Vascular Endothelial Growth Factor Receptor-related (Pvr) signaling down-regulate the pathway.
Protein Function (UniProtKB)
Non-receptor protein tyrosine phosphatase (PubMed:8463208). Required for maintaining dock/dreadlocks in its non-phosphorylated state (PubMed:12014990). Negative regulator of InR/insulin-like receptor signaling through dephosphorylation of tyrosines when recruited by dock/dreadlocks (PubMed:21707536).
(UniProt, Q9W0G1)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\Ptp61F for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9W0G1)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.52

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.42

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ptp61F-RA
FBtr0072718
NM_057339
2115
548
Ptp61F-RB
FBtr0072717
NM_057340
1835
535
Ptp61F-RC
FBtr0072716
NM_167874
1796
530
Ptp61F-RD
FBtr0072719
NM_167875
3495
431
Ptp61F-RE
FBtr0310161
NM_001274324
5167
431
Additional Transcript Data and Comments
Reported size (kB)

2.8, 2.0 (northern blot)

(McLaughlin and Dixon, 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ptp61F-PA
FBpp0072602
62.1
548
5.24
Q9W0G1
NP_476687
AAF47487
Ptp61F-PB
FBpp0072601
61.0
535
5.76
NP_476688
AAF47486
Ptp61F-PC
FBpp0072600
60.5
530
5.90
NP_728600
AAN11475
Ptp61F-PD
FBpp0072603
48.5
431
4.81
Q8IRH4
NP_728601
AAN11476
Ptp61F-PE
FBpp0301846
48.5
431
4.81
Q8IRH4
NP_001261253
AGB93948
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

431 aa isoforms: Ptp61F-PD, Ptp61F-PE
Additional Polypeptide Data and Comments
Reported size (kDa)

72 (kD observed)

(Clemens et al., 1996)

548, 535 (aa); 62, 61 (kD)

(McLaughlin and Dixon, 1993)
Comments

In vitro and in vivo interaction between Ptp61F and dock proteins were demonstrated. One or more of the SH3 domains of dock protein likely mediate the interaction with a region of the Ptp61F protein containing five PXXP-motifs (where X represents any amino acid).

(Clemens et al., 1996)
External Data
Subunit Structure (UniProtKB)

Interacts (via C-terminus) with dock/dreadlocks; this interaction is independent of insulin stimulation and is required for dephosphorylation of the insulin-like receptor InR.

(UniProt, Q9W0G1)
Domain

Contains 5 Potential PXXP motifs that may mediate interaction with the SH3 domains of dock/dreadlocks.

(UniProt, Q9W0G1)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptp61F using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.30

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & pupal stage & adult stage
(Clemens et al., 1996)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 9 -- 10
central brain primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 14
presumptive embryonic/larval central nervous system
(Clemens et al., 1996)
adult stage | male
hub cell

Comment: low

(Issigonis and Matunis, 2012)
cyst progenitor cell

Comment: low

(Issigonis and Matunis, 2012)
cyst cell of testis
(Issigonis and Matunis, 2012)
somatic cell of testis
(Issigonis and Matunis, 2012)
spermatogenesis & adult stage | male
male germline stem cell

Comment: low

(Issigonis and Matunis, 2012)
male germline cyst
(Issigonis and Matunis, 2012)
spermatogonium
(Issigonis and Matunis, 2012)
Additional Descriptive Data

Ptp61F mRNA is expressed at low levels around the niche and in the hub, germline stem cells, and cyst progenitor cells (also called somatic cyst stem cells or CySCs). It is more strongly expressed in differentiating germ cells and somatic cells.

(Issigonis and Matunis, 2012)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(McLaughlin and Dixon, 1993)
located_in mitochondrial envelope
inferred from direct assay
(McLaughlin and Dixon, 1993)
is_active_in nucleus
inferred from direct assay
(Hu et al., 2025)
located_in nucleus
inferred from direct assay
(McLaughlin and Dixon, 1993)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Huang et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ptp61F in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 41 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ptp61F
Transgenic constructs containing regulatory region of Ptp61F
Aberrations (Deficiencies and Duplications) ( 12 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(3L)BSC178)
lethal (with Df(3L)BSC289)
lethal (with Df(3L)ED207)
lethal (with Df(3L)ED4196)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4arm.PU
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with Df(3L)ED207)
viable (with Df(3L)ED4196)
viable (with Ptp61F4-10)
viable (with Ptp61FGE29807)
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
female semi-sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
fertile
male fertile
Other Phenotypes
Allele
abnormal starvation stress response | adult stage, with Scer\GAL4elav-C155
decreased cell number, with Scer\GAL4dpp.PU
decreased cell size, with Scer\GAL4dpp.PU
decreased fecundity | female
decreased occurrence of cell division | larval stage, with Scer\GAL4ey.PH
increased body weight | adult stage, with Scer\GAL4elav-C155
increased cell death | oogenesis
increased rate of adult locomotory behavior | adult stage, with Scer\GAL4elav-C155
short lived
visible, with Scer\GAL4dpp.PU
visible, with Scer\GAL4GMR.PF
Phenotype manifest in
Allele
eye, with Scer\GAL4GMR.PF
eye disc, with Scer\GAL4ey.PH
first posterior wing cell, with Scer\GAL4dpp.PU
interommatidial bristle, with Scer\GAL4GMR.PF
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (47)
Hsap\PTPN2
13 of 14
Yes
Yes
2  
Hsap\PTPN1
11 of 14
No
Yes
Hsap\PTPN5
2 of 14
No
Yes
1  
Hsap\PTPN7
2 of 14
No
No
Hsap\PTPN9
2 of 14
No
No
Hsap\PTPN12
2 of 14
No
Yes
Hsap\PTPN18
2 of 14
No
Yes
Hsap\PTPN20
2 of 14
No
Yes
Hsap\PTPN22
2 of 14
No
Yes
Hsap\PTPN23
2 of 14
No
No
Hsap\PTPRG
2 of 14
No
No
Hsap\PTPRR
2 of 14
No
Yes
1  
Hsap\PTPRZ1
2 of 14
No
No
Hsap\CDC14A
1 of 14
No
No
Hsap\CDC14B
1 of 14
No
No
Hsap\CDC14C
1 of 14
No
No
Hsap\DUSP8
1 of 14
No
No
Hsap\DUSP12
1 of 14
No
No
1  
Hsap\DUSP16
1 of 14
No
No
Hsap\DUSP23
1 of 14
No
No
Hsap\PTPDC1
1 of 14
No
No
Hsap\PTPMT1
1 of 14
No
No
3  
Hsap\PTPN3
1 of 14
No
No
Hsap\PTPN4
1 of 14
No
No
Hsap\PTPN6
1 of 14
No
No
3  
Hsap\PTPN11
1 of 14
No
No
7  
Hsap\PTPN13
1 of 14
No
No
Hsap\PTPN14
1 of 14
No
No
Hsap\PTPN21
1 of 14
No
No
Hsap\PTPRA
1 of 14
No
No
1  
Hsap\PTPRB
1 of 14
No
No
Hsap\PTPRC
1 of 14
No
No
Hsap\PTPRD
1 of 14
No
No
Hsap\PTPRE
1 of 14
No
No
Hsap\PTPRF
1 of 14
No
No
2  
Hsap\PTPRH
1 of 14
No
No
Hsap\PTPRJ
1 of 14
No
No
Hsap\PTPRK
1 of 14
No
No
Hsap\PTPRM
1 of 14
No
No
Hsap\PTPRN2
1 of 14
No
No
Hsap\PTPRN
1 of 14
No
No
Hsap\PTPRO
1 of 14
No
No
1  
Hsap\PTPRQ
1 of 14
No
No
Hsap\PTPRS
1 of 14
No
No
Hsap\PTPRT
1 of 14
No
No
Hsap\PTPRU
1 of 14
No
No
Hsap\RNGTT
1 of 14
No
No
6  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (30)
Rnor\Ptpn2
12 of 14
Yes
Yes
Rnor\Ptpn1
11 of 14
No
Yes
Rnor\Ptpn9
2 of 14
No
No
Rnor\Ptpn12
2 of 14
No
Yes
Rnor\Ptpn18
2 of 14
No
Yes
Rnor\Ptpn20
2 of 14
No
Yes
Rnor\Ptpn22
2 of 14
No
Yes
Rnor\Ptprg
2 of 14
No
No
Rnor\Ptprz1
2 of 14
No
No
Rnor\Ptpn3
1 of 14
No
No
Rnor\Ptpn4
1 of 14
No
No
Rnor\Ptpn5
1 of 14
No
No
Rnor\Ptpn6
1 of 14
No
No
Rnor\Ptpn7
1 of 14
No
No
Rnor\Ptpn11
1 of 14
No
No
Rnor\Ptpn13
1 of 14
No
No
Rnor\Ptpn23
1 of 14
No
No
Rnor\Ptpra
1 of 14
No
No
Rnor\Ptprb
1 of 14
No
No
Rnor\Ptprd
1 of 14
No
No
Rnor\Ptpre
1 of 14
No
No
Rnor\Ptprf
1 of 14
No
No
Rnor\Ptprh
1 of 14
No
No
Rnor\Ptprj
1 of 14
No
No
Rnor\Ptprk
1 of 14
No
No
Rnor\Ptprm
1 of 14
No
No
Rnor\Ptpro
1 of 14
No
No
Rnor\Ptprq
1 of 14
No
No
Rnor\Ptprr
1 of 14
No
No
Rnor\Ptprs
1 of 14
No
No
Mus musculus (laboratory mouse) (32)
Mmus\Ptpn2
13 of 14
Yes
Yes
Mmus\Ptpn1
10 of 14
No
Yes
Mmus\Ptpn9
2 of 14
No
No
Mmus\Ptpn20
2 of 14
No
Yes
Mmus\Ptpn22
2 of 14
No
Yes
Mmus\Ptpn23
2 of 14
No
No
Mmus\Ptprz1
2 of 14
No
No
Mmus\Ptpn3
1 of 14
No
No
Mmus\Ptpn4
1 of 14
No
No
Mmus\Ptpn5
1 of 14
No
No
Mmus\Ptpn6
1 of 14
No
No
Mmus\Ptpn7
1 of 14
No
No
Mmus\Ptpn11
1 of 14
No
No
Mmus\Ptpn12
1 of 14
No
No
Mmus\Ptpn13
1 of 14
No
No
Mmus\Ptpn18
1 of 14
No
No
Mmus\Ptpn21
1 of 14
No
No
Mmus\Ptpra
1 of 14
No
No
Mmus\Ptprb
1 of 14
No
No
Mmus\Ptprd
1 of 14
No
No
Mmus\Ptpre
1 of 14
No
No
Mmus\Ptprf
1 of 14
No
No
Mmus\Ptprg
1 of 14
No
No
Mmus\Ptprh
1 of 14
No
No
Mmus\Ptprj
1 of 14
No
No
Mmus\Ptprk
1 of 14
No
No
Mmus\Ptprm
1 of 14
No
No
0  
Mmus\Ptpro
1 of 14
No
No
Mmus\Ptprq
1 of 14
No
No
Mmus\Ptprr
1 of 14
No
No
Mmus\Ptprs
1 of 14
No
No
Mmus\Ptprv
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\ptpn2
8 of 13
Yes
Yes
Xtro\ptpn1
7 of 13
No
Yes
Xtro\cdc14b
1 of 13
No
No
Xtro\dusp16
1 of 13
No
No
Xtro\dusp28
1 of 13
No
No
Xtro\itgb4
1 of 13
No
No
Xtro\pdgfa
1 of 13
No
No
Xtro\ptpn9l
1 of 13
No
No
Xtro\ptpn9
1 of 13
No
No
Xtro\ptpn11b
1 of 13
No
No
Xtro\ptpn11
1 of 13
No
No
Xtro\ptpn14
1 of 13
No
No
Xtro\ptpn21
1 of 13
No
No
Xtro\ptpn23
1 of 13
No
No
Xtro\ptprt
1 of 13
No
No
Xtro\ptpru
1 of 13
No
No
Xtro\ptprz1
1 of 13
No
No
Danio rerio (Zebrafish) (36)
Drer\ptpn2b
13 of 14
Yes
Yes
Drer\ptpn2a
12 of 14
No
Yes
Drer\ptpn1
11 of 14
No
Yes
Drer\ca16b
2 of 14
No
No
Drer\ptpn9a
2 of 14
No
No
Drer\ptpn9b
2 of 14
No
No
Drer\ptpn18
2 of 14
No
Yes
Drer\ptpn23a
2 of 14
No
No
Drer\ptprga
2 of 14
No
No
Drer\ptprz1b
2 of 14
No
No
Drer\ptpn3
1 of 14
No
No
Drer\ptpn4a
1 of 14
No
No
Drer\ptpn4b
1 of 14
No
No
Drer\ptpn5
1 of 14
No
No
Drer\ptpn6
1 of 14
No
No
Drer\ptpn11a
1 of 14
No
No
Drer\ptpn11b
1 of 14
No
No
Drer\ptpn13
1 of 14
No
Yes
Drer\ptpn20
1 of 14
No
Yes
Drer\ptpn21
1 of 14
No
No
Drer\ptpra
1 of 14
No
No
Drer\ptprb
1 of 14
No
No
Drer\ptprc
1 of 14
No
No
Drer\ptprdb
1 of 14
No
No
Drer\ptprea
1 of 14
No
No
Drer\ptpreb
1 of 14
No
No
Drer\ptprfa
1 of 14
No
No
Drer\ptprfb
1 of 14
No
No
Drer\ptprja
1 of 14
No
No
Drer\ptprjb.1
1 of 14
No
No
Drer\ptprjb.2
1 of 14
No
No
Drer\ptprk
1 of 14
No
No
Drer\ptprq
1 of 14
No
No
Drer\ptprsa
1 of 14
No
No
Drer\ptprt
1 of 14
No
No
Drer\ptprz1a
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (86)
Cele\F36H1.3
4 of 14
Yes
Yes
Cele\T22C1.8
4 of 14
Yes
Yes
Cele\B0207.1
2 of 14
No
Yes
Cele\B0280.11
2 of 14
No
Yes
Cele\C02B10.6
2 of 14
No
Yes
Cele\C07E3.4
2 of 14
No
Yes
Cele\C15H7.3
2 of 14
No
Yes
Cele\C17H12.3
2 of 14
No
Yes
Cele\C17H12.5
2 of 14
No
Yes
Cele\C33F10.8
2 of 14
No
Yes
Cele\C33H5.16
2 of 14
No
Yes
Cele\C46A5.1
2 of 14
No
Yes
Cele\C55B7.3
2 of 14
No
Yes
Cele\egg-4
2 of 14
No
No
Cele\egg-5
2 of 14
No
No
Cele\F20H11.4
2 of 14
No
Yes
Cele\F25H5.7
2 of 14
No
Yes
Cele\F35C11.2
2 of 14
No
Yes
Cele\F36H12.10
2 of 14
No
Yes
Cele\F38H4.4
2 of 14
No
Yes
Cele\F40G12.10
2 of 14
No
Yes
Cele\F47B3.1
2 of 14
No
Yes
Cele\F47B3.6
2 of 14
No
Yes
Cele\F47B3.7
2 of 14
No
Yes
Cele\F55F8.7
2 of 14
No
Yes
Cele\F57H12.5
2 of 14
No
Yes
Cele\K07F5.6
2 of 14
No
Yes
Cele\K07F5.8
2 of 14
No
Yes
Cele\K09F6.3
2 of 14
No
Yes
Cele\M05B5.1
2 of 14
No
Yes
Cele\M05D6.3
2 of 14
No
Yes
Cele\pph-2
2 of 14
No
Yes
Cele\ptp-5.1
2 of 14
No
Yes
Cele\ptp-5.2
2 of 14
No
Yes
Cele\ptp-5.3
2 of 14
No
Yes
Cele\ptpn-22
2 of 14
No
Yes
Cele\sdf-9
2 of 14
No
Yes
Cele\T04F3.3
2 of 14
No
Yes
Cele\T27A3.5
2 of 14
No
Yes
Cele\T28F4.3
2 of 14
No
Yes
Cele\W01B6.6
2 of 14
No
Yes
Cele\Y39A3A.4
2 of 14
No
No
Cele\Y54F10BM.3
2 of 14
No
Yes
Cele\Y62F5A.10
2 of 14
No
Yes
Cele\Y71F9AL.4
2 of 14
No
Yes
Cele\Y116A8C.37
2 of 14
No
Yes
Cele\ZK354.8
2 of 14
No
Yes
Cele\ZK484.7
2 of 14
No
Yes
Cele\ZK809.1
2 of 14
No
Yes
Cele\B0280.17
1 of 14
No
No
Cele\cdc-14
1 of 14
No
No
Cele\cel-1
1 of 14
No
No
Cele\clr-1
1 of 14
No
No
Cele\dep-1
1 of 14
No
No
Cele\eak-6
1 of 14
No
No
Cele\egg-3
1 of 14
No
No
Cele\F10G8.1
1 of 14
No
Yes
Cele\F20B6.1
1 of 14
No
Yes
Cele\F20B6.6
1 of 14
No
Yes
Cele\F28C6.8
1 of 14
No
No
Cele\F47B3.2
1 of 14
No
No
Cele\hpo-7
1 of 14
No
Yes
Cele\M04G7.2
1 of 14
No
No
Cele\pir-1
1 of 14
No
No
Cele\ptp-1
1 of 14
No
No
Cele\ptp-2
1 of 14
No
No
Cele\ptp-3
1 of 14
No
No
Cele\ptp-4
1 of 14
No
No
Cele\R09E10.2
1 of 14
No
Yes
Cele\R155.3
1 of 14
No
Yes
Cele\sre-45
1 of 14
No
Yes
Cele\T04F3.5
1 of 14
No
Yes
Cele\T12B3.1
1 of 14
No
No
Cele\T13H5.1
1 of 14
No
No
Cele\VW02B12L.2
1 of 14
No
Yes
Cele\W03F11.4
1 of 14
No
Yes
Cele\Y5F2A.3
1 of 14
No
Yes
Cele\Y39B6A.30
1 of 14
No
No
Cele\Y48G1C.5
1 of 14
No
Yes
Cele\Y48G9A.9
1 of 14
No
No
Cele\Y69A2AR.19
1 of 14
No
Yes
Cele\Y80D3A.8
1 of 14
No
No
Cele\Y113G7C.1
1 of 14
No
No
Cele\ZK616.8
1 of 14
No
Yes
Cele\ZK616.65
1 of 14
No
No
Cele\ZK783.3
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (21)
Agam\AgaP_AGAP005352
11 of 12
Yes
Yes
Agam\AgaP_AGAP001109
2 of 12
No
No
Agam\AgaP_AGAP000492
1 of 12
No
No
Agam\AgaP_AGAP002342
1 of 12
No
No
Agam\AgaP_AGAP002438
1 of 12
No
No
Agam\AgaP_AGAP002832
1 of 12
No
No
Agam\AgaP_AGAP003187
1 of 12
No
No
Agam\AgaP_AGAP003976
1 of 12
No
No
Agam\AgaP_AGAP004246
1 of 12
No
No
Agam\AgaP_AGAP005142
1 of 12
No
No
Agam\AgaP_AGAP007118
1 of 12
No
No
Agam\AgaP_AGAP008077
1 of 12
No
No
Agam\AgaP_AGAP008127
1 of 12
No
No
Agam\AgaP_AGAP009628
1 of 12
No
No
Agam\AgaP_AGAP009975
1 of 12
No
No
Agam\AgaP_AGAP010090
1 of 12
No
No
Agam\AgaP_AGAP010093
1 of 12
No
No
Agam\AgaP_AGAP011155
1 of 12
No
No
Agam\AgaP_AGAP011586
1 of 12
No
No
Agam\AgaP_AGAP011650
1 of 12
No
No
Agam\AgaP_AGAP012237
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\PTP1
4 of 13
Yes
No
Atha\AT2G35680
1 of 13
No
No
Atha\AT5G56610
1 of 13
No
No
Atha\DSPTP1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\PTP1
6 of 13
Yes
Yes
Scer\PTP3
2 of 13
No
No
Scer\CDC14
1 of 13
No
No
Scer\PTP2
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\pyp1
2 of 12
Yes
Yes
Spom\pyp2
1 of 12
No
No
Spom\pyp3
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ptp61F. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (18)
Ptpmeg2
5 of 13
Lar
4 of 13
Ptp4E
4 of 13
Ptp10D
4 of 13
Ptp52F
4 of 13
Ptp69D
4 of 13
Ptp99A
4 of 13
IA-2
3 of 13
CG42327
2 of 13
csw
2 of 13
Pez
2 of 13
Ptp36E
2 of 13
PTP-ER
2 of 13
Ptpmeg
2 of 13
Cdc14
1 of 13
Mkp3
1 of 13
mop
1 of 13
mRNA-cap
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
Ptp61FHMS00421
model of  intestinal cancer
CEA
(Liu et al., 2022)
Ptp61FΔ
model of  cancer
CEA with Ras85DV12.cUa.UAS
(Liu et al., 2022)
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 2 )
Allele
Disease
Interaction
References
Ptp61FHMS00421
model of  intestinal cancer
is ameliorated by exUASp.EGFP
(Liu et al., 2022)
is ameliorated by ykiGD11187
(Liu et al., 2022)
ameliorates  amyotrophic lateral sclerosis type 10
modeled by Hsap\TARDBPUAS.cEa
(Lee et al., 2020)
model of  cancer
is ameliorated by Hsap\PTPN2UAS.Tag:HA
(Liu et al., 2022)
Ptp61FΔ
exacerbates  cancer
modeled by Ras85DV12.cUa.UAS
(Liu et al., 2022)
ameliorates  cancer
modeled by sav3
(Liu et al., 2022)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
PTPN2; protein tyrosine phosphatase non-receptor type 2
13 of 14
PROTEIN-TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE, 2; PTPN2
       
      PTPN1; protein tyrosine phosphatase non-receptor type 1
      11 of 14
      176885
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      External Data
      Subunit Structure (UniProtKB)
      Interacts (via C-terminus) with dock/dreadlocks; this interaction is independent of insulin stimulation and is required for dephosphorylation of the insulin-like receptor InR.
      (UniProt, Q9W0G1 )
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3L
      Recombination map
      3-0.5
      Cytogenetic map
      61F7-62A2
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      61F7-62A2
      Limits computationally determined from genome sequence between P{PZ}l(3)0264002640 and P{EP}rhoEP3704&P{PZ}l(3)0622606226;
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      61F-61F
      (McLaughlin, 1993.5.19)
      61F-61F
      (determined by in situ hybridisation)
      (McLaughlin and Dixon, 1993)
      Experimentally Determined Recombination Data
      Location

      3-0.5

      (FlyBase, 2016)

      3-1.8

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (34)
      Genomic Clones (66)
      cDNA Clones (214)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Clemens et al., 1996, McLaughlin and Dixon, 1993)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          Ptp61F negatively regulates JAK/STAT signaling and is also a transcriptional target of JAK/STAT signaling.

          (Baeg et al., 2005)

          S2-derived S2-NP cells treated with dsRNA made from templates generated with primers directed against Ptp61F experience a more than four-fold increase in Stat92E-dependent reporter activity and a significant increase in Stat92E phosphorylation. dsRNA knock-down also results in a dramatic increase in tyrosine phosphorylation of hop protein.

          (Baeg et al., 2005)

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)

          Area matching Drosophila EST AA567483 (inverted).

          (Davies, 2001.3.15)

          The spatial and temporal expression of two alternative transcripts of Ptp61F during Drosophila embryogenesis has been analysed in wild-type embryos and in embryos mutant for pair-rule and segment-polarity genes.

          (Ursuliak et al., 1997)

          Spatial and temporal transcript accumulation pattern in ovaries is determined by in situ hybridisation.

          (Fitzpatrick et al., 1995)

          Two 3' splice variants of this gene generate two proteins that differ in their C-termini. One is targeted to the cytoplasmic membrane, the other to the nucleus.

          (McLaughlin and Dixon, 1993)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: Ptp61F BEST:LP01280

          (FlyBase, 1996-)

          Source for merge of: Ptp61F anon-WO0140519.98 anon-WO0118547.297

          (FlyBase, 1996-)

          Source for merge of: Ptp61F CG9178

          (FlyBase, 1996-)

          Source for merge of: Ptp61F CPtp62A

          (FlyBase, 1992-)
          Additional comments

          Source for merge of Ptp61F BEST:LP01280 was a shared cDNA ( date:030206 ).

          (FlyBase, 1996-)

          Source for merge of Ptp61F anon-WO0140519.98 anon-WO0118547.297 was sequence comparison ( date:051113 ).

          (FlyBase, 1996-)

          Release 1 annotation CG9178 corresponds to part of release 3.2 annotation CG9181 (which is Ptp61F).

          (FlyBase, 1996-)
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (24)
          Reported As
          Symbol Synonym
          BEST:LP01280
          CG9178
          CG9181
          (Kolkhof et al., 2017, Tchankouo-Nguetcheu et al., 2014, Jaspers et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Lee et al., 2008, Molnar et al., 2006, Morrison et al., 2000)
          CPtp62A
          DCPTP62A
          (Gomez-Skarmeta et al., 1993)
          DPTP61F
          (Muda et al., 2002, Clemens et al., 2000, den Hertog, 1999, Stoker and Dutta, 1998, Ursuliak et al., 1997, Nieto, 1996, Ursuliak et al., 1996, Fitzpatrick et al., 1995)
          PTP1B
          (Tchankouo-Nguetcheu et al., 2014)
          PTP1b
          (Lee et al., 2020)
          PTP61F
          (Hong et al., 2016, Li et al., 2015, Chen et al., 2014, Buszard et al., 2013, Morin-Poulard et al., 2013, Wang et al., 2013, Stec and Zeidler, 2011, Wu et al., 2011, Ku et al., 2009, Chang et al., 2008, Huang et al., 2007, Huang et al., 2007, Perrimon and Mathey-Prevot, 2007, Arbouzova and Zeidler, 2006, Gotea and Makalowski, 2006, Baeg et al., 2005, Andersen et al., 2004, Kung, 1993)
          Ptp-61F
          (Chen et al., 2012)
          Ptp61F
          (Chen et al., 2025, Hu et al., 2025, Collins et al., 2024, Olivares et al., 2023, Liu et al., 2022, Chou et al., 2021, Layalle et al., 2021, Ostalé et al., 2021, Watanabe and Riddle, 2021, Winbush and Singh, 2021, Ge et al., 2019, Hall et al., 2019, Lee et al., 2019, Bazzi et al., 2018, Willoughby et al., 2017, Clandinin and Owens, 2016-, Hunter et al., 2016, Kučerová et al., 2016, Lamiable et al., 2016, Saadin and Starz-Gaiano, 2016, Shen et al., 2016, Aradska et al., 2015, Gene Disruption Project members, 2015-, Hatzihristidis et al., 2015, Hsu et al., 2015, Tarayrah et al., 2015, Lim et al., 2014, Sopko et al., 2014, Tchankouo-Nguetcheu et al., 2014, Toshima et al., 2014, Valanne, 2014, Bausek, 2013, Carter, 2013, de Celis et al., 2013.9.11, Kwon et al., 2013, Mbodj et al., 2013, Zeidler and Bausek, 2013, Chen et al., 2012, Gurudatta et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Friedman et al., 2011, Yu et al., 2010, Hilger et al., 2009, Tan et al., 2009, Bakal et al., 2008, Lee et al., 2008, Baeg et al., 2007, Chen et al., 2007, Molnar et al., 2006, Lipatov et al., 2005, Muller et al., 2005, Wei et al., 2003)
          Ptp61f
          (Shweta et al., 2024, Lee et al., 2020, Jeon et al., 2017)
          R-PTP 61F
          (Morrison et al., 2000)
          anon-WO0118547.297
          anon-WO0140519.98
          dPTP61F
          (Erfurth and Schmucker, 2008, Walchli et al., 2000, Garcia-Alonso, 1999, McCarty, 1998, Clemens et al., 1996, McLaughlin and Dixon, 1993)
          dptp61F
          (Ursuliak et al., 1997)
          ptp61F
          (Harrison et al., 2021, Lourido et al., 2021, Bausek, 2013, Guan et al., 2011, Wright et al., 2011, Arbouzova and Zeidler, 2006, Muller, 2005)
          Name Synonyms
          Cytoplasmic Protein tyrosine phosphatase 62A
          (Gomez-Skarmeta et al., 1993)
          Protein tyrosine phosphatase
          (Saadin and Starz-Gaiano, 2016)
          Protein tyrosine phosphatase 61F
          (Wang et al., 2013, Jaspers et al., 2012, Guan et al., 2011)
          protein tyrosine phosphatase
          (McLaughlin, 1995.9.13, McLaughlin, 1993.5.19, McLaughlin, 1993.5.19, McLaughlin, 1993.5.19, McLaughlin, 1993.5.19)
          protein tyrosine phosphatase 61F
          (Lee et al., 2008)
          protein-tyrosine-phosphatase
          (Zou et al., 2000)
          Secondary FlyBase IDs
          • FBgn0003138
          • FBgn0035219
          • FBgn0043788
          • FBgn0044527
          • FBgn0062112
          • FBgn0023399
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 81 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (179)