FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Ire1
Open Close
General Information
Symbol
Dmel\Ire1
Species
D. melanogaster
Name
Inositol-requiring enzyme-1
Annotation Symbol
CG4583
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261984
Gene Model Status
Current
Stock Availability
13 publicly available
Enzyme Name (EC)
Gene Summary
Inositol-requiring enzyme-1 (Ire1) encodes a transmembrane protein that mediates the unfolded protein response. Misfolded peptides in the endoplasmic reticulum activate the RNase activity of the product of Ire1, thereby promoting the cleavage of its downstream substrates, such as Xbp1 mRNA. The product of Ire1 is also required for photoreceptor differentiation. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

ire-1, Ire, Ire1α

Key Links
Genomic Location
Cytogenetic map
92B3-92B3
Sequence location
Recombination map
3-67
RefSeq locus
NT_033777 REGION:19853908..19861291
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables RNA endonuclease activity
inferred from mutant phenotype
(Ryoo et al., 2007, Hollien and Weissman, 2006)
inferred from direct assay
(Plongthongkum et al., 2007)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719
(InterPro Project Members, 2004-)
enables protein kinase activity
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271
(InterPro Project Members, 2004-)
enables protein serine/threonine kinase activity
inferred from electronic annotation with InterPro:IPR045133
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000359335
(GO Reference Genome Project, 2011-)
enables RNA endonuclease activity
inferred from biological aspect of ancestor with PANTHER:PTN000359335
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR045133
(InterPro Project Members, 2004-)
enables RNA nuclease activity
inferred from electronic annotation with InterPro:IPR010513
(InterPro Project Members, 2004-)
enables unfolded protein binding
inferred from biological aspect of ancestor with PANTHER:PTN000359335
(GO Reference Genome Project, 2011-)
Biological Process (15 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
involved_in cellular response to starvation
inferred from direct assay
(Zhao et al., 2021)
involved_in compound eye photoreceptor cell differentiation
inferred from mutant phenotype
(Coelho et al., 2013)
involved_in Golgi organization
inferred from mutant phenotype
(Zacharogianni et al., 2011)
involved_in IRE1-mediated unfolded protein response
inferred from genetic interaction with FLYBASE:Gp93; FB:FBgn0039562
(Xu et al., 2024)
inferred from direct assay
(Plongthongkum et al., 2007)
inferred from mutant phenotype
(Ryoo et al., 2007)
involved_in lipid homeostasis
inferred from mutant phenotype
(Zhao et al., 2021)
involved_in mRNA catabolic process
inferred from mutant phenotype
(Hollien and Weissman, 2006)
involved_in negative regulation of organ growth
inferred from mutant phenotype
(Yang et al., 2022)
involved_in regulation of RNA splicing
inferred from direct assay
(Plongthongkum et al., 2007)
involved_in response to endoplasmic reticulum stress
inferred from direct assay
(Plongthongkum et al., 2007)
involved_in rhabdomere morphogenesis
inferred from mutant phenotype
(Coelho et al., 2013)
involved_in triglyceride mobilization
inferred from mutant phenotype
(Zhao et al., 2021)
NOT involved_in compound eye photoreceptor fate commitment
inferred from mutant phenotype
(Coelho et al., 2013)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum unfolded protein response
inferred from electronic annotation with InterPro:IPR045133
(InterPro Project Members, 2004-)
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
inferred from biological aspect of ancestor with PANTHER:PTN000359335
(GO Reference Genome Project, 2011-)
involved_in IRE1-mediated unfolded protein response
traceable author statement
(Yang et al., 2022)
inferred from biological aspect of ancestor with PANTHER:PTN000359335
(GO Reference Genome Project, 2011-)
involved_in mRNA processing
inferred from electronic annotation with InterPro:IPR010513
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in endoplasmic reticulum
inferred from biological aspect of ancestor with PANTHER:PTN000359335
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
protein serine/threonine kinase activity
Summaries
Gene Snapshot
Inositol-requiring enzyme-1 (Ire1) encodes a transmembrane protein that mediates the unfolded protein response. Misfolded peptides in the endoplasmic reticulum activate the RNase activity of the product of Ire1, thereby promoting the cleavage of its downstream substrates, such as Xbp1 mRNA. The product of Ire1 is also required for photoreceptor differentiation. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
UNCLASSIFIED CONVENTIONAL PROTEIN KINASE DOMAIN KINASES -
This group comprises conventional protein kinase domain kinases that do not classify under other groups in FlyBase.
UNCLASSIFIED RNA ENDONUCLEASES -
This group comprises endoribonucleases that do not classify under other groups in FlyBase.
Summary (Interactive Fly)

protein kinase, endonuclease, a regulator of the unfolded protein response, leading to the activation of the transcription factor Xbp1 - regulated Ire1-dependent decay - regulation of RNA splicing - photoreceptor differentiation and rhabdomere morphogenesis

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ire1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A8JR46)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ire1-RB
FBtr0113248
NM_001104369
4034
1074
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ire1-PB
FBpp0112160
120.2
1074
6.49
A8JR46
NP_001097839
ABW08704
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ire1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.05

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ire1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ire1
Transgenic constructs containing regulatory region of Ire1
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of first instar larval stage
lethal - all die before end of larval stage | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
Other Phenotypes
Allele
abnormal cell number, with Scer\GAL4MESO.dome
abnormal cell number, with Scer\GAL4Tep4.PU
abnormal eye color | somatic clone
abnormal eye color | somatic clone, with Ire1f02170
abnormal eye color | somatic clone, with Ire1RNase-Dead.Tag:HA
abnormal immune response | adult stage, with Scer\GAL4c564
abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4Ddc.PU
abnormal mitotic cell cycle | larval stage, with Scer\GAL4MESO.dome
abnormal size | larval stage
abnormal starvation stress response | adult stage, with Scer\GAL4apolpp.PB
abnormal starvation stress response | adult stage, with Scer\GAL4Cg.PA
abnormal starvation stress response | adult stage, with Scer\GAL4r4
abnormal starvation stress response | adult stage, with Scer\GAL4αTub84B.PL
decreased cell number | adult stage, with Scer\GAL4GMR.long
decreased cell number | adult stage | progressive, with Scer\GAL4Ddc.PU
decreased cell number | larval stage | somatic clone
decreased cell number | larval stage | somatic clone, with Scer\GAL4Act.PU
decreased size | adult stage, with Scer\GAL4Cg.PA
decreased size | adult stage, with Scer\GAL4GMR.PU
decreased size | adult stage, with Scer\GAL4αTub84B.PL
increased cell death | larval stage | somatic clone
increased cell death | larval stage | somatic clone, with Scer\GAL4Act.PU
increased cell death | third instar larval stage, with Scer\GAL4GMR.long
increased mortality | adult stage, with Scer\GAL4apolpp.PB
increased mortality | adult stage, with Scer\GAL4Cg.PA
increased mortality | adult stage, with Scer\GAL4r4
increased mortality | adult stage, with Scer\GAL4αTub84B.PL
increased size | adult stage, with Scer\GAL4Cg.PA
increased size | larval stage, with Scer\GAL4Cg.PA
short lived, with Scer\GAL4Ddc.PU
visible | adult stage, with Scer\GAL4GMR.long
visible | adult stage, with Scer\GAL4GMR.PU
Phenotype manifest in
Allele
autolysosome | adult stage, with Scer\GAL4GMR.long
autolysosome | larval stage, with Scer\GAL4GMR.long
autophagosome | adult stage, with Scer\GAL4GMR.long
autophagosome | larval stage, with Scer\GAL4GMR.long
dopaminergic PPM1 neuron | progressive, with Scer\GAL4Ddc.PU
dopaminergic PPM2 neuron | progressive, with Scer\GAL4Ddc.PU
dopaminergic PPM3 neuron | progressive, with Scer\GAL4Ddc.PU
embryonic/larval lymph gland, with Scer\GAL4MESO.dome
embryonic/larval lymph gland, with Scer\GAL4Tep4.PU
eye, with Scer\GAL4GMR.long
eye, with Scer\GAL4GMR.PU
eye-antennal disc | somatic clone
eye-antennal disc | somatic clone, with Scer\GAL4Act.PU
eye disc, with Scer\GAL4GMR.long
eye photoreceptor cell, with Scer\GAL4GMR.long
interommatidial bristle, with Scer\GAL4GMR.long
lipid droplet | adult stage, with Scer\GAL4Cg.PA
lipid droplet | adult stage, with Scer\GAL4αTub84B.PL
lipid droplet | larval stage, with Scer\GAL4Cg.PA
ommatidium, with Scer\GAL4GMR.long
ommatidium | somatic clone
pigment granule | decreased number | somatic clone
pigment granule | decreased number | somatic clone, with Ire1f02170
pigment granule | decreased number | somatic clone, with Ire1RNase-Dead.Tag:HA
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (46)
Hsap\ERN2
13 of 14
Yes
Yes
Hsap\ERN1
12 of 14
No
Yes
Hsap\RNASEL
2 of 14
No
Yes
Hsap\ARAF
1 of 14
No
No
Hsap\AURKA
1 of 14
No
No
Hsap\C8orf44-SGK3
1 of 14
No
No
Hsap\CAMK1D
1 of 14
No
No
1  
Hsap\CAMK1G
1 of 14
No
No
Hsap\CAMK2B
1 of 14
No
No
2  
Hsap\CAMK2D
1 of 14
No
No
1  
Hsap\CDK15
1 of 14
No
No
Hsap\CHEK2
1 of 14
No
No
Hsap\DCLK3
1 of 14
No
No
Hsap\EPHB1
1 of 14
No
No
2  
Hsap\LIMK1
1 of 14
No
No
Hsap\MAP2K5
1 of 14
No
No
Hsap\MAP3K11
1 of 14
No
No
Hsap\MAP3K12
1 of 14
No
No
Hsap\MAP3K13
1 of 14
No
No
Hsap\MAPK4
1 of 14
No
No
Hsap\MARK4
1 of 14
No
No
4  
Hsap\NEK9
1 of 14
No
No
1  
Hsap\NEK11
1 of 14
No
No
Hsap\PBK
1 of 14
No
No
Hsap\PHKG1
1 of 14
No
No
Hsap\PLK1
1 of 14
No
No
Hsap\PLK4
1 of 14
No
No
Hsap\PRKD1
1 of 14
No
No
2  
Hsap\PRKD2
1 of 14
No
No
1  
Hsap\PRKD3
1 of 14
No
No
1  
Hsap\PSKH1
1 of 14
No
No
Hsap\RPS6KA1
1 of 14
No
No
Hsap\RPS6KA2
1 of 14
No
No
Hsap\RPS6KA3
1 of 14
No
No
1  
Hsap\RPS6KA5
1 of 14
No
No
Hsap\RPS6KA6
1 of 14
No
No
1  
Hsap\SGK3
1 of 14
No
No
Hsap\SIK2
1 of 14
No
No
Hsap\SIK3
1 of 14
No
No
Hsap\SNRK
1 of 14
No
No
1  
Hsap\STK3
1 of 14
No
No
1  
Hsap\STK4
1 of 14
No
No
2  
Hsap\STK39
1 of 14
No
No
Hsap\TP53RK
1 of 14
No
No
1  
Hsap\TSSK3
1 of 14
No
No
1  
Hsap\TTK
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (32)
Rnor\Ern1
13 of 14
Yes
Yes
Rnor\Ern2
13 of 14
Yes
Yes
Rnor\Aurka
1 of 14
No
No
Rnor\Aurkb
1 of 14
No
No
Rnor\Camk1d
1 of 14
No
No
Rnor\Camk1g
1 of 14
No
No
Rnor\Camk2b
1 of 14
No
No
Rnor\Dclk1
1 of 14
No
No
Rnor\Dclk3
1 of 14
No
No
Rnor\Eif2ak2
1 of 14
No
No
Rnor\Ephb3
1 of 14
No
No
Rnor\Limk1
1 of 14
No
No
Rnor\LOC685619
1 of 14
No
No
Rnor\Map3k11
1 of 14
No
No
Rnor\Map3k12
1 of 14
No
No
Rnor\Map3k13
1 of 14
No
No
Rnor\Mapk15
1 of 14
No
No
Rnor\Pak2
1 of 14
No
No
Rnor\Pak3
1 of 14
No
No
Rnor\Pak6
1 of 14
No
No
Rnor\Phkg1
1 of 14
No
No
Rnor\Plk1
1 of 14
No
No
Rnor\Plk4
1 of 14
No
No
Rnor\Plk5
1 of 14
No
No
Rnor\Prkd2
1 of 14
No
No
Rnor\Pskh1
1 of 14
No
No
Rnor\Rnasel
1 of 14
No
Yes
Rnor\Rps6ka1
1 of 14
No
No
Rnor\Rps6ka2
1 of 14
No
No
Rnor\Rps6ka3
1 of 14
No
No
Rnor\Rps6ka6
1 of 14
No
No
Rnor\Tp53rk
1 of 14
No
No
Mus musculus (laboratory mouse) (34)
Mmus\Ern1
13 of 14
Yes
Yes
Mmus\Ern2
12 of 14
No
Yes
Mmus\Rnasel
2 of 14
No
Yes
Mmus\Aurka
1 of 14
No
No
Mmus\Camk1d
1 of 14
No
No
Mmus\Camk1g
1 of 14
No
No
Mmus\Ephb1
1 of 14
No
No
Mmus\Gm4513
1 of 14
No
Yes
Mmus\Gm4565
1 of 14
No
Yes
Mmus\Gm7168
1 of 14
No
No
Mmus\Gm7356
1 of 14
No
No
Mmus\Gm7358
1 of 14
No
No
Mmus\Limk1
1 of 14
No
No
Mmus\Map3k11
1 of 14
No
No
Mmus\Map3k12
1 of 14
No
No
Mmus\Map3k13
1 of 14
No
No
Mmus\Pak1
1 of 14
No
No
Mmus\Pak2
1 of 14
No
No
Mmus\Pak3
1 of 14
No
No
Mmus\Pak6
1 of 14
No
No
Mmus\Phkg1
1 of 14
No
No
Mmus\Plk1
1 of 14
No
No
1  
Mmus\Plk4
1 of 14
No
No
Mmus\Plk5
1 of 14
No
No
Mmus\Prkd2
1 of 14
No
No
Mmus\Prkd3
1 of 14
No
No
Mmus\Pskh1
1 of 14
No
No
Mmus\Rps6ka1
1 of 14
No
No
Mmus\Rps6ka2
1 of 14
No
No
Mmus\Rps6ka3
1 of 14
No
No
Mmus\Smok3c
1 of 14
No
No
Mmus\Stk39
1 of 14
No
No
Mmus\Trp53rka
1 of 14
No
No
Mmus\Trp53rkb
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (37)
Xtro\ern2
11 of 13
Yes
Yes
Xtro\ern1
5 of 13
No
Yes
Xtro\amer1
1 of 13
No
Yes
Xtro\camk1
1 of 13
No
No
Xtro\cdk14
1 of 13
No
No
Xtro\cdk15
1 of 13
No
No
Xtro\cdk16
1 of 13
No
No
Xtro\chek2
1 of 13
No
No
Xtro\dclk1
1 of 13
No
No
Xtro\dclk3
1 of 13
No
No
Xtro\eif2ak2
1 of 13
No
No
Xtro\epha7
1 of 13
No
No
Xtro\lats2
1 of 13
No
No
Xtro\LOC100145764
1 of 13
No
No
Xtro\LOC100485259
1 of 13
No
No
Xtro\LOC116406512
1 of 13
No
No
Xtro\map3k13
1 of 13
No
No
Xtro\map3k19
1 of 13
No
No
Xtro\nek9
1 of 13
No
No
Xtro\neu4
1 of 13
No
No
Xtro\nuak1
1 of 13
No
No
Xtro\nuak2
1 of 13
No
No
Xtro\pak2
1 of 13
No
No
Xtro\pak4
1 of 13
No
No
Xtro\plk1
1 of 13
No
No
Xtro\plk3
1 of 13
No
No
Xtro\plk4
1 of 13
No
No
Xtro\prkcq
1 of 13
No
No
Xtro\prkx
1 of 13
No
No
Xtro\pskh1
1 of 13
No
No
Xtro\rab11fip4l
1 of 13
No
No
Xtro\rps6ka3
1 of 13
No
No
Xtro\sdr39u1
1 of 13
No
No
Xtro\sik3
1 of 13
No
Yes
Xtro\snrk
1 of 13
No
No
Xtro\stk3
1 of 13
No
No
Xtro\ulk3
1 of 13
No
No
Danio rerio (Zebrafish) (35)
Drer\ern2
12 of 14
Yes
Yes
Drer\ern1
9 of 14
No
Yes
Drer\LOC100334396
2 of 14
No
Yes
Drer\aurkb
1 of 14
No
No
Drer\camk1a
1 of 14
No
No
Drer\camk1b
1 of 14
No
No
Drer\camk1da
1 of 14
No
No
Drer\camk1db
1 of 14
No
No
Drer\camk1ga
1 of 14
No
No
Drer\camk2d1
1 of 14
No
No
Drer\cdk15
1 of 14
No
No
Drer\LOC100536316
1 of 14
No
No
Drer\map3k3
1 of 14
No
No
Drer\map3k4
1 of 14
No
No
Drer\map3k12
1 of 14
No
No
Drer\map3k21
1 of 14
No
No
Drer\map4k6
1 of 14
No
No
Drer\obscna
1 of 14
No
No
Drer\pdpk1b
1 of 14
No
No
Drer\phkg2
1 of 14
No
No
Drer\plk1
1 of 14
No
No
Drer\plk4
1 of 14
No
No
Drer\prkcdb
1 of 14
No
No
Drer\prkcq
1 of 14
No
No
Drer\pskh1
1 of 14
No
No
Drer\rps6ka1
1 of 14
No
No
Drer\rps6ka2
1 of 14
No
No
Drer\rps6ka3a
1 of 14
No
No
Drer\rps6kal
1 of 14
No
No
Drer\rps6kb1b
1 of 14
No
No
Drer\si:ch73-60h1.1
1 of 14
No
No
Drer\si:ch211-45c16.2
1 of 14
No
No
Drer\sik2a
1 of 14
No
No
Drer\snrkb
1 of 14
No
No
Drer\tp53rk
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (19)
Cele\ire-1
13 of 14
Yes
Yes
Cele\abl-1
1 of 14
No
No
Cele\air-1
1 of 14
No
No
Cele\cdk-11.1
1 of 14
No
No
Cele\dkf-1
1 of 14
No
No
Cele\dlk-1
1 of 14
No
No
Cele\F32D8.1
1 of 14
No
No
Cele\F52C12.6
1 of 14
No
No
Cele\gakh-1
1 of 14
No
No
Cele\gck-3
1 of 14
No
No
Cele\max-2
1 of 14
No
No
Cele\nsy-1
1 of 14
No
No
Cele\pak-1
1 of 14
No
No
Cele\plk-1
1 of 14
No
No
Cele\plk-3
1 of 14
No
No
Cele\rskn-1
1 of 14
No
No
Cele\sek-1
1 of 14
No
No
Cele\unc-43
1 of 14
No
No
Cele\wee-1.3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (12)
Agam\AgaP_AGAP004176
12 of 12
Yes
Yes
Agam\AgaP_AGAP001752
1 of 12
No
No
Agam\AgaP_AGAP002154
1 of 12
No
No
Agam\AgaP_AGAP002647
1 of 12
No
No
Agam\AgaP_AGAP003040
1 of 12
No
No
Agam\AgaP_AGAP004239
1 of 12
No
No
Agam\AgaP_AGAP006094
1 of 12
No
No
Agam\AgaP_AGAP007333
1 of 12
No
No
Agam\AgaP_AGAP007476
1 of 12
No
No
Agam\AgaP_AGAP010710
1 of 12
No
No
Agam\AgaP_AGAP012244
1 of 12
No
No
Agam\AgaP_AGAP012499
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (61)
Atha\IRE1-1
10 of 13
Yes
Yes
Atha\IRE1A
10 of 13
Yes
Yes
Atha\AT3G11870
7 of 13
No
Yes
Atha\AT1G01540
1 of 13
No
No
Atha\AT1G51870
1 of 13
No
No
Atha\AT3G15220
1 of 13
No
No
Atha\AT3G15890
1 of 13
No
No
Atha\AT3G46930
1 of 13
No
No
Atha\AT4G01330
1 of 13
No
Yes
Atha\AT4G04960
1 of 13
No
Yes
Atha\AT4G10010
1 of 13
No
No
Atha\AT4G19110
1 of 13
No
No
Atha\AT4G24100
1 of 13
No
No
Atha\AT4G31170
1 of 13
No
No
Atha\AT5G26110
1 of 13
No
No
Atha\AT5G57610
1 of 13
No
No
Atha\AT5G58950
1 of 13
No
No
Atha\ATSK12
1 of 13
No
No
Atha\CDPK6
1 of 13
No
No
Atha\CDPK9
1 of 13
No
No
Atha\CERK1
1 of 13
No
No
Atha\CES101
1 of 13
No
Yes
Atha\CIPK23
1 of 13
No
No
Atha\CPK5
1 of 13
No
No
Atha\CPK6
1 of 13
No
No
Atha\CPK9
1 of 13
No
No
Atha\CPK15
1 of 13
No
No
Atha\CPK17
1 of 13
No
No
Atha\CPK18
1 of 13
No
No
Atha\CPK19
1 of 13
No
No
Atha\CPK20
1 of 13
No
No
Atha\CPK22
1 of 13
No
No
Atha\CPK24
1 of 13
No
No
Atha\CPK26
1 of 13
No
No
Atha\CPK32
1 of 13
No
No
Atha\CPK33
1 of 13
No
No
Atha\CTR1
1 of 13
No
No
Atha\GCN2
1 of 13
No
No
Atha\GRIK1
1 of 13
No
No
Atha\HT1
1 of 13
No
No
Atha\MAPKKK7
1 of 13
No
No
Atha\MAPKKK9
1 of 13
No
No
Atha\MEKK1
1 of 13
No
No
Atha\MEKK3
1 of 13
No
No
Atha\MPK15
1 of 13
No
No
Atha\MPK16
1 of 13
No
No
Atha\MPK17
1 of 13
No
No
Atha\MPK19
1 of 13
No
No
Atha\MPK20
1 of 13
No
No
Atha\NP1
1 of 13
No
No
Atha\NP2
1 of 13
No
No
Atha\PEPKR2
1 of 13
No
No
Atha\PK1
1 of 13
No
No
Atha\SIK1
1 of 13
No
No
Atha\SK 11
1 of 13
No
No
Atha\SK32
1 of 13
No
No
Atha\SnRK1.3
1 of 13
No
No
Atha\SOS2
1 of 13
No
No
Atha\TMK1
1 of 13
No
No
Atha\WAKL4
1 of 13
No
Yes
Atha\WRKY19
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (11)
Scer\IRE1
11 of 13
Yes
Yes
Scer\BCK1
1 of 13
No
No
Scer\BUD32
1 of 13
No
No
Scer\DUN1
1 of 13
No
No
Scer\FPK1
1 of 13
No
No
Scer\MKK2
1 of 13
No
No
Scer\MPS1
1 of 13
No
No
Scer\PKH1
1 of 13
No
No
Scer\PKH2
1 of 13
No
No
Scer\RAD53
1 of 13
No
No
Scer\RCK1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (6)
Spom\ire1
10 of 12
Yes
Yes
Spom\ark1
1 of 12
No
No
Spom\cdc7
1 of 12
No
Yes
Spom\cdr1
1 of 12
No
No
Spom\ksg1
1 of 12
No
No
Spom\SPAP27G11.07c
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ire1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (15)
aurA
1 of 13
BubR1
1 of 13
CaMKI
1 of 13
grp
1 of 13
hpo
1 of 13
KP78a
1 of 13
Mekk1
1 of 13
Myt1
1 of 13
PhKγ
1 of 13
Raf
1 of 13
S6k
1 of 13
SAK
1 of 13
sgg
1 of 13
Tcs5
1 of 13
wnd
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 4 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ERN2; endoplasmic reticulum to nucleus signaling 2
    13 of 14
    604034
        ERN1; endoplasmic reticulum to nucleus signaling 1
        12 of 14
        604033
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Ire1
            suppressible
            Atg5
            (Zheng et al., 2023)
            scrib|Ire1
            suppressible
            Atg6
            (Zheng et al., 2023)
            Ire1
            suppressible
            Atg6
            (Zheng et al., 2023)
            scrib|Ire1
            suppressible
            Atg6|bsk
            (Zheng et al., 2023)
            Ire1
            suppressible
            Atg7
            (Yan et al., 2019)
            Ire1
            suppressible
            Atg8b
            (Yan et al., 2019)
            Ire1
            suppressible
            Atg12
            (Zheng et al., 2023)
            Ire1
            suppressible
            Atg13
            (Zheng et al., 2023)
            scrib|Ire1
            suppressible
            Atg13
            (Zheng et al., 2023)
            Ire1
            suppressible
            Atg14
            (Zheng et al., 2023)
            Ire1
            suppressible
            bsk
            (Yan et al., 2019)
            scrib|Ire1
            suppressible
            bsk
            (Zheng et al., 2023)
            scrib|Ire1
            suppressible
            bsk|Atg13
            (Zheng et al., 2023)
            Ire1
            suppressible
            Diap1
            (Zheng et al., 2023)
            Ire1|scrib
            suppressible
            Diap1
            (Zheng et al., 2023)
            Ire1
            suppressible
            Dronc
            (Zheng et al., 2023)
            Ire1|scrib
            suppressible
            Dronc
            (Zheng et al., 2023)
            Ire1|ninaE
            suppressible
            wg
            (Park et al., 2023)
            Ire1
            enhanceable
            Xbp1
            (Yan et al., 2019)
            Ire1
            suppressible
            Xbp1
            (Zhao et al., 2021, Yan et al., 2019)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            egr
            enhanceable
            Ire1
            (Zheng et al., 2023)
            ninaE
            enhanceable
            Ire1
            (Park et al., 2023, Kang et al., 2012)
            Nos
            suppressible
            Ire1
            (Cho et al., 2024)
            Rab5
            enhanceable
            Ire1
            (Zheng et al., 2023)
            scrib
            enhanceable
            Ire1
            (Zheng et al., 2023)
            scrib
            suppressible
            Ire1
            (Zheng et al., 2023)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-67
            Cytogenetic map
            92B3-92B3
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            92B3-92B3
            Limits computationally determined from genome sequence between P{EP}EP650 and P{PZ}l(3)1058510585
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            92B1-92B7
            (Cavener et al., 2000.3.10)
            Experimentally Determined Recombination Data
            Location

            3-67

            (FlyBase, 2016)

            3-69.4

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (13)
            Genomic Clones (12)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (7)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
              Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                  Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Cell Line Information
                    Publicly Available Cell Lines
                     
                      Other Stable Cell Lines
                       
                        Other Comments

                        Changes in expression profiles associated with the unfolded protein response have been analyzed in S2 cells following treatment with dsRNA made from templates generated with primers directed against this gene.

                        (Hollien and Weissman, 2006)

                        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                        (Kiger et al., 2003)
                        Relationship to Other Genes
                        Source for database merge of

                        Source for merge of: ire-1 Ire

                        (FlyBase, 1992-)
                        Additional comments
                        Nomenclature History
                        Source for database identify of

                        Source for identity of: ire-1 CG4583

                        (Vaughn et al., 2001)

                        Source for identity of: Ire1 ire-1

                        (Hollien and Weissman, 2006)
                        Nomenclature comments
                        Etymology
                        Synonyms and Secondary IDs (18)
                        Reported As
                        Symbol Synonym
                        CG4583
                        (Kumar et al., 2016, Park et al., 2014, Ling and Salvaterra, 2011, Ni et al., 2011.7.19, Perkins et al., 2009, Qin et al., 2008, Hollien and Weissman, 2006, Fetherson and Vaughn, 2004, Pile et al., 2003, Brody et al., 2002, Vaughn et al., 2001)
                        ERN1
                        (Kumar et al., 2016)
                        IRE-1
                        (Kongsung et al., 2024)
                        IRE-like
                        (Morrison et al., 2000)
                        IRE1
                        (Liu et al., 2024, Xu et al., 2024, Kumar and Maity, 2021, Yamazoe et al., 2021, Yu and Hyun, 2021, Zarini-Gakiye et al., 2021, Yan et al., 2019, Kang et al., 2017, Song et al., 2017, Kim et al., 2015, Ryoo, 2015, Wang et al., 2015, Park et al., 2014, Péan and Dionne, 2014, Ryoo et al., 2013, Rincon-Limas et al., 2012, Qin et al., 2008, Hollien and Weissman, 2006, Hollien and Weissman, 2006)
                        IRE1α
                        (Loganathan et al., 2021)
                        Ire
                        Ire-1
                        (Garcia et al., 2012, Ling and Salvaterra, 2011, Ryoo and Steller, 2007)
                        Ire1
                        (Couto-Lima et al., 2025, Nedachi et al., 2025, Proshkina et al., 2025, Cho et al., 2024, Sahana et al., 2023, Zheng et al., 2023, Cairrão et al., 2022, Ding et al., 2022, Huang et al., 2022, Pun et al., 2022, Yang et al., 2022, Yin et al., 2022, Mitra and Ryoo, 2021, Zhao et al., 2021, Funk et al., 2020, Gupta and Stocker, 2020, Mitra and Ryoo, 2019, Yan et al., 2019, Hall et al., 2018, Moehlman et al., 2018, Palu and Chow, 2018, Urra et al., 2018, Huang et al., 2017, Song et al., 2017, Tsuda et al., 2017, Xu et al., 2016, Coelho et al., 2014, Sopko et al., 2014, Coelho et al., 2013, Moore et al., 2013, Plongthongkum et al., 2007)
                        Ire1α
                        (Myers et al., 2022, Pandey et al., 2018)
                        dIRE1
                        (Geething et al., 2000)
                        dire-1
                        (Vaughn et al., 2001)
                        dmIRE-1
                        (Temviriyanukul et al., 2024)
                        ire-1
                        (Zacharogianni et al., 2011, Kang and Ryoo, 2008, Mattila et al., 2008, Kang and Ryoo, 2007, Ryoo et al., 2007, Stanyon et al., 2004)
                        ire1
                        (Fangninou et al., 2023, Ryoo et al., 2013, Kang et al., 2012)
                        Name Synonyms
                        Inositol required 1
                        (Plongthongkum et al., 2007)
                        Inositol-requiring enzyme-1
                        (Ling and Salvaterra, 2011, Hollien and Weissman, 2006)
                        Ire
                        inositol-requiring enzyme-1
                        (Qin et al., 2008)
                        ire-1
                        Secondary FlyBase IDs
                        • FBgn0038736
                        • FBgn0041204
                        Datasets (0)
                        Study focus (0)
                        Experimental Role
                        Project
                        Project Type
                        Title
                        Study result (0)
                        Result
                        Result Type
                        Title
                        External Crossreferences and Linkouts ( 37 )
                        Sequence Crossreferences
                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                        Other crossreferences
                        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                        InterPro - A database of protein families, domains and functional sites
                        KEGG Genes - Molecular building blocks of life in the genomic space.
                        MARRVEL_MODEL - MARRVEL (model organism gene)
                        Linkouts
                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                        DroID - A comprehensive database of gene and protein interactions.
                        DRSC - Results frm RNAi screens
                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                        References (124)