FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Gene: Dmel\SkpA
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General Information
Symbol
Dmel\SkpA
Species
D. melanogaster
Name
SKP1-related A
Annotation Symbol
CG16983
Feature Type
protein_coding_gene
FlyBase ID
FBgn0025637
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
SKP1-related A (SkpA) encodes a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Skp1, dSkpA, l(1)G0037, EG:115C2.4 , l(1)G0109

Key Links
Genomic Location
Cytogenetic map
1B14-1B14
Sequence location
Recombination map
1-0
RefSeq locus
NC_004354 REGION:656114..657899
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:mi; FB:FBgn0261786
(Szuplewski et al., 2009)
enables ubiquitin ligase complex scaffold activity
inferred from physical interaction with FLYBASE:fsd; FB:FBgn0033813
(Liu and Ma, 2011)
inferred from physical interaction with FLYBASE:ci; FB:FBgn0004859
(Smelkinson et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables cullin family protein binding
inferred from biological aspect of ancestor with PANTHER:PTN000126179
(GO Reference Genome Project, 2011-)
Biological Process (18 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
involved_in centrosome duplication
inferred from mutant phenotype
(Murphy, 2003)
involved_in chromosome condensation
inferred from mutant phenotype
(Murphy, 2003)
involved_in DNA endoreduplication
inferred from mutant phenotype
(Murphy, 2003)
involved_in mitotic cell cycle
inferred from high throughput mutant phenotype
(Ducat et al., 2008)
involved_in negative regulation of antimicrobial peptide production
inferred from mutant phenotype
(Khush et al., 2002)
involved_in negative regulation of apoptotic process
inferred from mutant phenotype
(Fereres et al., 2013)
inferred from genetic interaction with FLYBASE:rpr; FB:FBgn0011706
(Fereres et al., 2013)
inferred from genetic interaction with FLYBASE:Diap1; FB:FBgn0260635
(Fereres et al., 2013)
involved_in negative regulation of canonical Wnt signaling pathway
inferred from mutant phenotype
(Roberts et al., 2012)
involved_in negative regulation of hippo signaling
inferred from mutant phenotype
(Tokamov et al., 2021, Zhang et al., 2015)
involved_in negative regulation of insulin receptor signaling pathway
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Wong et al., 2013)
involved_in negative regulation of JNK cascade
inferred from mutant phenotype
(Brace et al., 2014)
involved_in negative regulation of peptidoglycan recognition protein signaling pathway
inferred from mutant phenotype
(Khush et al., 2002)
involved_in negative regulation of synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(Brace et al., 2014)
involved_in neuron remodeling
inferred from mutant phenotype
(Wong et al., 2013)
involved_in positive regulation of mitotic cell cycle
inferred from mutant phenotype
(Murphy, 2003)
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process
inferred from mutant phenotype
(Roberts et al., 2012)
involved_in positive regulation of synaptonemal complex assembly
inferred from mutant phenotype
(Barbosa et al., 2021)
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
inferred from direct assay
(Liu and Ma, 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000126179
(GO Reference Genome Project, 2011-)
involved_in ubiquitin-dependent protein catabolic process
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with SGD:S000002736
(Gene Ontology Curators, 2002-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of SCF ubiquitin ligase complex
inferred from direct assay
(Barbosa et al., 2021, Wong et al., 2013, Zhang et al., 2013, Ghorbani et al., 2011, Smelkinson et al., 2007, Bocca et al., 2001)
inferred from mutant phenotype
(Roberts et al., 2012)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of SCF ubiquitin ligase complex
inferred from sequence or structural similarity with SGD:S000002736
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
SKP1-related A (SkpA) encodes a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
SKP1 GENE FAMILY -
Skp1 is a component of the Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It acts as an adaptor binding cullin 1 and an F box protein. In D.mel, six Skp1 homologous have been identified, but only SkpA has been characterised as part of an SCF complex. (Adapted from FBrf0159039 and FBrf0217546).
SCF-SLMB UBIQUITIN LIGASE COMPLEX -
SCF-slmb ubiquitin ligase complex ubiquitinates proteins, targeting them for degradation by the proteasome. (FBrf0217546).
Pathway (FlyBase)
NEGATIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY -
Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
NEGATIVE REGULATORS OF INSULIN-LIKE RECEPTOR SIGNALING PATHWAY -
Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
NEGATIVE REGULATORS OF IMD SIGNALING PATHWAY -
Negative regulators of the immune deficiency (Imd) pathway result in the decreased activity of the NFκB-like transcription factor Rel in the nucleus. Negative regulators are important in preventing damage to the host from over-activation of the pathway; preventing inappropriate triggering or terminating the response. (Adapted from FBrf0224587 and FBrf0238555.)
NEGATIVE REGULATORS OF HIPPO SIGNALING PATHWAY -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).
Summary (Interactive Fly)

component of protein degradation complex - regulates centrosome duplication, chromatin condensation, cell cycle progression and endoreduplication

Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\SkpA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O77430)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.52

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.39

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
SkpA-RA
FBtr0070123
NM_058042
1087
162
SkpA-RB
FBtr0070126
NM_166856
935
162
SkpA-RC
FBtr0070127
NM_166857
1050
162
SkpA-RD
FBtr0070124
NM_166858
1472
162
SkpA-RE
FBtr0070129
NM_166859
869
162
SkpA-RF
FBtr0070128
NM_166860
913
162
SkpA-RG
FBtr0070125
NM_166861
845
162
SkpA-RH
FBtr0100530
NM_001038729
1544
162
SkpA-RI
FBtr0345314
NM_001297826
826
162
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
SkpA-PA
FBpp0070118
18.6
162
4.27
O77430
NP_477390
AAF45538
SkpA-PB
FBpp0070121
18.6
162
4.27
O77430
NP_726690
AAF45539
SkpA-PC
FBpp0070122
18.6
162
4.27
O77430
NP_726691
AAN09024
SkpA-PD
FBpp0070119
18.6
162
4.27
O77430
NP_726692
AAG22362
SkpA-PE
FBpp0070124
18.6
162
4.27
O77430
NP_726693
AAN09025
SkpA-PF
FBpp0070123
18.6
162
4.27
O77430
NP_726694
AAF45540
SkpA-PG
FBpp0070120
18.6
162
4.27
O77430
NP_726695
AAN09026
SkpA-PH
FBpp0099971
18.6
162
4.27
O77430
NP_001033818
ABC67161
SkpA-PI
FBpp0311474
18.6
162
4.27
O77430
NP_001284755
AHN59226
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

162 aa isoforms: SkpA-PA, SkpA-PB, SkpA-PC, SkpA-PD, SkpA-PE, SkpA-PF, SkpA-PG, SkpA-PH, SkpA-PI
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SkpA using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.54

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of SCF ubiquitin ligase complex
inferred from direct assay
(Barbosa et al., 2021, Wong et al., 2013, Zhang et al., 2013, Ghorbani et al., 2011, Smelkinson et al., 2007, Bocca et al., 2001)
inferred from mutant phenotype
(Roberts et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SkpA in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of SkpA
Transgenic constructs containing regulatory region of SkpA
Aberrations (Deficiencies and Duplications) ( 10 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal, with Scer\GAL4insc-Mz1407
lethal, with Scer\GAL4Mef2.PR
lethal, with Scer\GAL4pnr-MD237
lethal | larval stage
lethal | pharate adult stage
lethal | prepupal stage
lethal | pupal stage
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die before end of pupal stage | heat sensitive
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable
viable, with Scer\GAL4GMR.PU
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal mitotic cell cycle
abnormal neuroanatomy | larval stage, with Scer\GAL4elav.PU
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
abnormal neuroanatomy | larval stage | maternal effect
abnormal neuroanatomy | larval stage | maternal effect (with Df(1)ED6443)
abnormal neuroanatomy | larval stage | maternal effect (with SkpA1)
abnormal neuroanatomy | larval stage | maternal effect (with SkpAG0389)
abnormal neuroanatomy | larval stage | maternal effect (with SkpAGD65)
abnormal neuroanatomy | pupal stage, with Scer\GAL4ppk.PG
abnormal neuroanatomy | pupal stage | somatic clone
abnormal neuroanatomy | somatic clone | third instar larval stage
abnormal size, with Scer\GAL4sd.PU
abnormal size | larval stage
decreased cell death | conditional, with Scer\GAL4hh.PU
increased cell death, with Scer\GAL4en.PU
increased cell death, with Scer\GAL4sd.PU
increased cell death | larval stage
increased occurrence of cell division | larval stage
melanotic mass phenotype | larval stage
radiation resistant | partially, with Scer\GAL4hh.PU
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
some die during larval stage
some die during larval stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage | heat sensitive
Phenotype manifest in
Allele
centrosome | increased number
chromatin
embryonic/larval neuromuscular junction, with Scer\GAL4elav.PU
embryonic/larval neuromuscular junction | larval stage | maternal effect
gamma Kenyon cell | pupal stage | somatic clone
gamma Kenyon cell | somatic clone | third instar larval stage
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
imaginal disc
Johnston organ | P-stage | somatic clone, with Scer\GAL4Act.PU
karyosome, with Scer\GAL4VP16.nanos.UTR
larval central nervous system
larval digestive system
larval dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4ppk.PG
larval fat body & nucleus
larval foregut & nucleus
larval hindgut & nucleus
larval midgut & nucleus
larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
leg joint, with Scer\GAL4Dll.PU
leg joint, with Scer\GAL4rn.PU
melanotic mass
NMJ bouton | larval stage, with Scer\GAL4elav.PU
NMJ bouton | larval stage | maternal effect
NMJ bouton | larval stage | maternal effect (with Df(1)ED6443)
NMJ bouton | larval stage | maternal effect (with SkpA1)
NMJ bouton | larval stage | maternal effect (with SkpAG0389)
NMJ bouton | larval stage | maternal effect (with SkpAGD65)
prothoracic tarsal segment, with Scer\GAL4Dll.PU
prothoracic tarsal segment, with Scer\GAL4rn.PU
sarcomere, with Scer\GAL4Mef2.PR
scolopidium | P-stage | somatic clone, with Scer\GAL4Act.PU
synaptonemal complex | oogenesis, with Scer\GAL4VP16.nanos.UTR
wing, with Scer\GAL4sd.PU
wing disc, with Scer\GAL4en.PU
wing disc, with Scer\GAL4sd.PU
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\SKP1
14 of 14
Yes
Yes
Hsap\ELOC
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
Rnor\Skp1
14 of 14
Yes
Yes
Rnor\Eloc
1 of 14
No
No
Rnor\LOC103691088
1 of 14
No
No
Rnor\LOC103694416
1 of 14
No
No
Mus musculus (laboratory mouse) (2)
Mmus\Skp1
13 of 14
Yes
Yes
Mmus\Eloc
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\skp1
8 of 13
Yes
Yes
Xtro\gcnt3
6 of 13
No
Yes
Xtro\eloc
1 of 13
No
No
Danio rerio (Zebrafish) (3)
Drer\skp1
14 of 14
Yes
Yes
Drer\eloca
1 of 14
No
No
Drer\elocb
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (24)
Cele\skr-1
14 of 14
Yes
Yes
Cele\skr-2
14 of 14
Yes
Yes
Cele\skr-3
9 of 14
No
Yes
Cele\skr-4
7 of 14
No
Yes
Cele\skr-5
7 of 14
No
Yes
Cele\skr-7
6 of 14
No
Yes
Cele\skr-9
6 of 14
No
Yes
Cele\skr-10
6 of 14
No
Yes
Cele\skr-12
6 of 14
No
Yes
Cele\skr-14
6 of 14
No
Yes
Cele\skr-15
6 of 14
No
Yes
Cele\skr-6
5 of 14
No
Yes
Cele\skr-8
5 of 14
No
Yes
Cele\skr-13
5 of 14
No
Yes
Cele\skr-16
5 of 14
No
Yes
Cele\skr-17
5 of 14
No
Yes
Cele\skr-18
5 of 14
No
Yes
Cele\skr-20
5 of 14
No
Yes
Cele\skr-19
4 of 14
No
Yes
Cele\skr-21
3 of 14
No
Yes
Cele\C42D4.18
1 of 14
No
Yes
Cele\elc-1
1 of 14
No
No
Cele\elc-2
1 of 14
No
No
Cele\F54F7.10
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP008719
12 of 12
Yes
Yes
Agam\AgaP_AGAP011535
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (22)
Atha\AT5G42190
12 of 13
Yes
Yes
Atha\SK11
12 of 13
Yes
Yes
Atha\SK12
12 of 13
Yes
Yes
Atha\SK13
12 of 13
Yes
Yes
Atha\SKP1
12 of 13
Yes
Yes
Atha\SK3
11 of 13
No
Yes
Atha\SK4
11 of 13
No
Yes
Atha\SK9
11 of 13
No
Yes
Atha\SK10
11 of 13
No
Yes
Atha\SK14
11 of 13
No
Yes
Atha\SK15
11 of 13
No
Yes
Atha\SK16
11 of 13
No
Yes
Atha\SK19
11 of 13
No
Yes
Atha\SK8
9 of 13
No
Yes
Atha\SK5
8 of 13
No
Yes
Atha\SK18
8 of 13
No
Yes
Atha\MEO
7 of 13
No
Yes
Atha\SK7
7 of 13
No
Yes
Atha\SK6
4 of 13
No
Yes
Atha\SK20
3 of 13
No
Yes
Atha\SK21
3 of 13
No
Yes
Atha\AT5G59140
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\SKP1
13 of 13
Yes
Yes
Scer\ELC1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\skp1
12 of 12
Yes
Yes
Spom\SPBC1861.07
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:SkpA. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (8)
SkpB
11 of 13
SkpC
10 of 13
SkpD
10 of 13
SkpF
10 of 13
SkpE
7 of 13
CG15800
3 of 13
CG43089
2 of 13
EloC
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    SkpAHMS00791
    model of  neurodegenerative disease
    CEA
    (Dabool et al., 2020)
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    SkpAHMS00791
    exacerbates  cancer
    modeled by RbfHMS03004
    (Parkhitko et al., 2021)
    SkpAUAS.ORF
    ameliorates  Parkinson's disease 1
    modeled by Hsap\SNCAUAS.cJa
    (Dabool et al., 2020)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SKP1; S-phase kinase associated protein 1
    14 of 14
    601434
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        SkpA - Amy-d
        experimental knowledge based
        (Guruharsha et al., 2011)
        SkpA - Blimp-1
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        SkpA - CG13085
        experimental knowledge based
        (Guruharsha et al., 2011)
        SkpA - CG13088
        experimental knowledge based
        (Guruharsha et al., 2011)
        SkpA - CG7148
        experimental knowledge based
        (Guruharsha et al., 2011)
        SkpA - CG7407
        experimental knowledge based
        (Guruharsha et al., 2011)
        SkpA - Cks85A
        anti tag coimmunoprecipitation, western blot
        (Ghorbani et al., 2011)
        SkpA - Cul1
        anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot, experimental knowledge based
        (Barbosa et al., 2021, Zhang et al., 2013, Guruharsha et al., 2011)
        SkpA - Cyt-c-p
        experimental knowledge based
        (Guruharsha et al., 2011)
        SkpA - Dsor1
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        SkpA - Fbxl7
        anti tag coimmunoprecipitation, anti tag western blot
        (Bosch et al., 2014)
        SkpA - Fbxo42
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Barbosa et al., 2021)
        SkpA - Fsn
        experimental knowledge based, tandem affinity purification, Identification by mass spectrometry
        (Brace et al., 2014, Guruharsha et al., 2011)
        SkpA - Pi3K21B
        anti tag coimmunoprecipitation, peptide massfingerprinting, Identification by mass spectrometry
        (Vinayagam et al., 2016, Glatter et al., 2011)
        SkpA - Ppa
        two hybrid, anti tag coimmunoprecipitation, anti tag western blot
        (Raj et al., 2000)
        SkpA - RYBP
        anti bait coimmunoprecipitation, western blot
        (Fereres et al., 2013)
        SkpA - SAK
        pull down, peptide massfingerprinting, anti tag coimmunoprecipitation
        (Cunha-Ferreira et al., 2013, Dzhindzhev et al., 2010)
        SkpA - ScsβA
        anti bait coimmunoprecipitation, western blot
        (Hughes et al., 2008)
        SkpA - Skp2
        anti tag coimmunoprecipitation, western blot, anti tag western blot
        (Dui et al., 2013, Ghorbani et al., 2011)
        SkpA - SkpB
        experimental knowledge based
        (Guruharsha et al., 2011)
        SkpA - SkpC
        experimental knowledge based
        (Guruharsha et al., 2011)
        SkpA - Smn
        anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot
        (Gray et al., 2018)
        SkpA - ci
        pull down, anti tag western blot
        (Smelkinson et al., 2007)
        SkpA - ds
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Kwon et al., 2013)
        SkpA - fsd
        anti tag coimmunoprecipitation, anti tag western blot
        (Liu and Ma, 2011)
        SkpA - hiw
        tandem affinity purification, Identification by mass spectrometry
        (Brace et al., 2014)
        SkpA - jet
        pull down, anti tag western blot
        (Koh et al., 2006)
        SkpA - mi
        pull down, western blot
        (Szuplewski et al., 2009)
        SkpA - morgue
        anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, autoradiography, western blot, experimental knowledge based
        (Zhou et al., 2013, Guruharsha et al., 2011, Wing et al., 2002)
        SkpA - ntc
        anti tag coimmunoprecipitation, western blot
        (Bader et al., 2010)
        SkpA - pall
        anti tag coimmunoprecipitation, western blot
        (Silva et al., 2007)
        SkpA - slmb
        anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot, experimental knowledge based
        (Barbosa et al., 2021, Xiao et al., 2015, Wong et al., 2013, Zhang et al., 2013, Guruharsha et al., 2011, Rogers et al., 2009, Silva et al., 2007)
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        SkpA
        suppressible
        bsk
        (Brace et al., 2014)
        SkpA
        suppressible
        Diap1
        (Fereres et al., 2013)
        SkpA
        suppressible
        InR
        (Wong et al., 2013)
        SkpA
        enhanceable
        InR
        (Wong et al., 2013)
        SkpA
        suppressible
        Jra
        (Brace et al., 2014)
        SkpA
        suppressible
        kay
        (Brace et al., 2014)
        SkpA
        enhanceable
        lok
        (Barbosa et al., 2021)
        SkpA
        suppressible
        rpr
        (Fereres et al., 2013)
        SkpA
        enhanceable
        RYBP
        (Fereres et al., 2013)
        SkpA|faf
        suppressible
        wnd
        (Brace et al., 2014)
        SkpA
        suppressible
        wnd
        (Brace et al., 2014)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Dref
        suppressible
        SkpA
        (Phuong Thao et al., 2006)
        grim::rpr
        suppressible
        SkpA|EP1216b
        (Wing et al., 2002)
        grim::rpr
        enhanceable
        SkpA
        (Wing et al., 2002)
        hiw
        enhanceable
        SkpA
        (Brace et al., 2014)
        rpr
        suppressible
        SkpA
        (Fereres et al., 2013)
        RYBP
        enhanceable
        SkpA
        (Fereres et al., 2013)
        α-Spec
        suppressible
        SkpA
        (Brace et al., 2014)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-0
        Cytogenetic map
        1B14-1B14
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        1B14-1B14
        Limits computationally determined from genome sequence between P{EP}DreddEP1412&P{EP}Suv4-20EP1216a and P{EP}sdkEP369
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        1C1-1C2
        (determined by in situ hybridisation) 1C (determined by in situ hybridisation) 1B7--8 (determined by in situ hybridisation)
        (Peter et al., 2002)
        1B13-1B13
        (Murphy, 1999.12.29)
        1C-1C
        (determined by in situ hybridisation)
        (Schäfer et al., 1999.6.15, Schäfer et al., 1999.8.12)
        1C1-1C2
        (determined by in situ hybridisation) 1B7--8 (determined by in situ hybridisation)
        (Schäfer et al., 1999.3.29)
        Experimentally Determined Recombination Data
        Location

        1-0

        (FlyBase, 2016)

        1-0.0

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (15)
        Genomic Clones (9)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (126)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Hughes et al., 2008)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            SkpA is a negative regulator of the wnd-JNK pathway, functioning to negatively regulate synapse growth during development and to promote axon degeneration following injury.

            (Brace et al., 2014)

            Animals mutant for skpA die as larvae.

            (Murphy et al., 1999)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: skpA EG:115C2.4

            (Murphy, 1999.3.10)

            Source for merge of: skpA l(1)G0109 l(1)G0389

            (Khush et al., 2002)

            Source for merge of: skpA l(1)G0058 l(1)G0037

            (Peter et al., 2002)

            Source for merge of: skpA anon-WO03040301.234 anon-WO03040301.236 anon-WO03040301.238

            (FlyBase, 1996-)
            Additional comments

            Source for merge of skpA anon-WO03040301.234 anon-WO03040301.236 anon-WO03040301.238 was sequence comparison ( date:051113 ).

            (FlyBase, 1996-)
            Nomenclature History
            Source for database identify of

            Source for identity of: skpA CG16983

            (Gong, 1999.11)

            Source for identity of: SkpA skpA

            (FlyBase, 2009-)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (24)
            Reported As
            Symbol Synonym
            CG16983
            (Çiçek et al., 2016, Hosono et al., 2015, Schertel et al., 2013, Cammarato et al., 2011, Glatter et al., 2011, Zhang et al., 2011, Ni et al., 2010.12.1, Zhang et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Ducat et al., 2008, Hughes et al., 2008, Gandhi et al., 2007, Murphy, 2003, Bourbon et al., 2002, Benos, 2000.12.13)
            EG:115C2.4
            (Benos et al., 2001, Benos, 2000.12.13)
            SKP1
            (Kondo and Perrimon, 2011)
            SKPA
            (Fukuyama et al., 2013)
            Skp
            (Kroeger et al., 2013, Alexandre et al., 2008)
            Skp1
            (Peng et al., 2022, Liu and Ma, 2011, Szuplewski et al., 2009, Shibutani et al., 2008, Jiang, 2002, Jin and Harper, 2002, Greaves, 2000, Raj et al., 2000)
            SkpA
            (Lawson et al., 2025, Lawson et al., 2025, Santos et al., 2025, Meyer et al., 2024, Nieken et al., 2023, Kang et al., 2022, Sebastian et al., 2022, Barbosa et al., 2021, Pang et al., 2021, Parkhitko et al., 2021, Tokamov et al., 2021, Gupta and Stocker, 2020, Hao et al., 2020, Wang et al., 2019, Collu et al., 2018, Gray et al., 2018, Kohzaki, 2018, Stephano et al., 2018, Lin et al., 2017, Pan et al., 2017, Suisse et al., 2017, Grill et al., 2016, Noble et al., 2016, Xiao et al., 2015, Zhang et al., 2015, Bosch et al., 2014, Brace et al., 2014, Cunha-Ferreira et al., 2013, Dui et al., 2013, Kroeger et al., 2013, Wong et al., 2013, Yamamoto et al., 2013-, Zhang et al., 2013, Zhang et al., 2013, Zhou et al., 2013, Fabian and Brill, 2012, Marthiens et al., 2012, Roberts et al., 2012, Tokusumi et al., 2012, Ghorbani et al., 2011, Guest et al., 2011, Bader et al., 2010, Dzhindzhev et al., 2010, Cunha-Ferreira et al., 2009, Menon and Meller, 2009, Szuplewski et al., 2009, Ducat et al., 2008, Hughes et al., 2008, Mentelová et al., 2008, Franc et al., 2007, Silva et al., 2007, Smelkinson et al., 2007, Bjorklund et al., 2006, Koh et al., 2006, Zielke et al., 2006, Park et al., 2004)
            anon-WO03040301.234
            anon-WO03040301.236
            anon-WO03040301.238
            dSKP1
            (Bhutani et al., 2012)
            dSkip-1
            (Kohzaki, 2018)
            dSkp-1
            (Heriche and O'Farrell, 2001)
            dSkpA
            (Heriche et al., 2003, Bocca et al., 2001, Muzzopappa et al., 2001)
            dskpA
            (Murphy et al., 1999)
            l(1)G0037
            (Schäfer et al., 1999.3.29, Schäfer et al., 1999.6.15)
            l(1)G0058
            (Schäfer et al., 1999.3.29)
            l(1)G0109
            (Schäfer et al., 1999.8.12)
            l(1)G0389
            (Schäfer et al., 1999.8.12)
            skpA
            (Xue et al., 2025, Dabool et al., 2020, Jin et al., 2020, Li et al., 2016, Guan et al., 2015, Ugrankar et al., 2015, Colin et al., 2014, Kim and Choe, 2014, Aparicio et al., 2013, Buster et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Strutt et al., 2013, Wong et al., 2013, Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Joyce et al., 2012, Du et al., 2011, Friedman et al., 2011, Neumüller et al., 2011, Toku et al., 2011, Popodi et al., 2010-, Venken et al., 2010, Bartkuhn et al., 2009, Deng et al., 2009, Rogers et al., 2009, Zsindely et al., 2009, Hoopfer et al., 2008, Roukens et al., 2008, Sakaguchi et al., 2008, Straub et al., 2008, DasGupta et al., 2007, Silva et al., 2007, Minakhina and Steward, 2006, Phuong Thao et al., 2006, Greene et al., 2005, Stanyon et al., 2004, Heriche et al., 2003)
            spkA
            (Bolshakov et al., 2002)
            Name Synonyms
            SCF-βTrCP complex
            (Marthiens and Basto, 2020)
            SKP1-related A
            Skp1-related gene A
            (Fukuyama et al., 2013)
            skpA
            (Cammarato et al., 2011)
            Secondary FlyBase IDs
            • FBgn0026694
            • FBgn0026706
            • FBgn0028296
            • FBgn0040198
            • FBgn0066818
            • FBgn0066819
            • FBgn0066820
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 109 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (197)