FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\neur
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General Information
Symbol
Dmel\neur
Species
D. melanogaster
Name
neuralized
Annotation Symbol
CG11988
Feature Type
protein_coding_gene
FlyBase ID
FBgn0002932
Gene Model Status
Current
Stock Availability
38 publicly available
Enzyme Name (EC)
Gene Summary
neuralized (neur) encodes an E3 ubiquitin ligase of the RING family. It is part of the Notch signaling pathway, where it is thought to contribute to the endocytosis-dependent activation of the ligand. It also has Notch-independent functions in epithelial morphogenesis. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

neu, Neuralised

Key Links
Genomic Location
Cytogenetic map
85C2-85C3
Sequence location
Recombination map
3-48
RefSeq locus
NT_033777 REGION:9020348..9039471
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (29 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables phosphatidylinositol phosphate binding
inferred from direct assay
(Skwarek et al., 2007)
enables protein binding
inferred from physical interaction with FLYBASE:E(spl)m4-BFM; FB:FBgn0002629,FLYBASE:E(spl)mα-BFM; FB:FBgn0002732
(Fontana and Posakony, 2009)
inferred from physical interaction with FLYBASE:Brd; FB:FBgn0000216
(Bardin and Schweisguth, 2006)
inferred from physical interaction with FLYBASE:E(spl)m4-BFM; FB:FBgn0002629
(Bardin and Schweisguth, 2006)
inferred from physical interaction with FLYBASE:E(spl)m6-BFM; FB:FBgn0002632
(Bardin and Schweisguth, 2006)
inferred from physical interaction with FLYBASE:E(spl)mα-BFM; FB:FBgn0002732
(Bardin and Schweisguth, 2006)
inferred from physical interaction with FLYBASE:Tom; FB:FBgn0026320
(Bardin and Schweisguth, 2006)
inferred from physical interaction with FLYBASE:Ocho; FB:FBgn0040296
(Bardin and Schweisguth, 2006)
inferred from physical interaction with FLYBASE:BobC; FB:FBgn0040485
(Bardin and Schweisguth, 2006)
inferred from physical interaction with FLYBASE:BobB; FB:FBgn0040486
(Bardin and Schweisguth, 2006)
inferred from physical interaction with FLYBASE:BobA; FB:FBgn0040487
(Bardin and Schweisguth, 2006)
enables ubiquitin protein ligase activity
inferred from direct assay
(Daskalaki et al., 2011, Lai et al., 2001, Yeh et al., 2001)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ubiquitin protein ligase activity
inferred from biological aspect of ancestor with PANTHER:PTN004361013
(GO Reference Genome Project, 2011-)
enables zinc ion binding
inferred from sequence model
(Ying et al., 2011)
Biological Process (21 terms)
Terms Based on Experimental Evidence (19 terms)
CV Term
Evidence
References
involved_in asymmetric cell division
inferred from mutant phenotype
(Le Borgne and Schweisguth, 2003)
involved_in compound eye development
inferred from mutant phenotype
(Lai and Rubin, 2001)
involved_in germ-line stem cell population maintenance
inferred from mutant phenotype
(Ward et al., 2006)
involved_in imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Lai et al., 2005)
involved_in intracellular protein localization
inferred from mutant phenotype
(Roegiers et al., 2005)
involved_in long-term memory
inferred from mutant phenotype
(Pavlopoulos et al., 2008)
involved_in mesoderm development
inferred from mutant phenotype
(Corbin et al., 1991)
involved_in negative regulation of lamellocyte differentiation
inferred from mutant phenotype
(Small et al., 2014)
involved_in nervous system development
inferred from mutant phenotype
(Lai and Rubin, 2001)
involved_in neuroblast fate determination
inferred from mutant phenotype
(Bodmer et al., 1993)
involved_in peripheral nervous system development
inferred from mutant phenotype
(Lai and Rubin, 2001, Salzberg et al., 1994)
involved_in positive regulation of endocytosis
inferred from mutant phenotype
(Fontana and Posakony, 2009, Bardin and Schweisguth, 2006, Pitsouli and Delidakis, 2005)
involved_in positive regulation of Notch signaling pathway
inferred from mutant phenotype
(Bardin and Schweisguth, 2006, Lai et al., 2005, Wang and Struhl, 2005)
inferred from genetic interaction with FLYBASE:Delta; FB:FBgn0000463
(Daskalaki et al., 2011)
inferred from genetic interaction with FLYBASE:mib1; FB:FBgn0263601
(Berndt et al., 2017, Le Borgne et al., 2005)
inferred from genetic interaction with FLYBASE:Delta; FB:FBgn0000463,FLYBASE:Ser; FB:FBgn0004197
(Pitsouli and Delidakis, 2005)
involved_in protein polyubiquitination
inferred from direct assay
(Daskalaki et al., 2011)
involved_in regulation of compound eye photoreceptor development
inferred from mutant phenotype
(Li and Baker, 2004)
involved_in regulation of photoreceptor cell differentiation
inferred from mutant phenotype
(Li and Baker, 2004)
involved_in sensory organ development
inferred from mutant phenotype
(Yeh et al., 2000)
involved_in sensory organ precursor cell fate determination
inferred from mutant phenotype
(Lai et al., 2005, Yeh et al., 2000)
inferred from direct assay
(Derivery et al., 2015)
involved_in ventral cord development
inferred from high throughput mutant phenotype
(Bivik et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in regulation of Notch signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000276953
(GO Reference Genome Project, 2011-)
involved_in ubiquitin-dependent endocytosis
inferred from biological aspect of ancestor with PANTHER:PTN000276953
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Perez-Mockus et al., 2017, Skwarek et al., 2007, Le Borgne and Schweisguth, 2003)
colocalizes_with endosome
inferred from direct assay
(Commisso and Boulianne, 2007)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Le Borgne and Schweisguth, 2003)
located_in plasma membrane
inferred from direct assay
(Commisso and Boulianne, 2007, Skwarek et al., 2007, Yeh et al., 2001, Yeh et al., 2000)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
ubiquitin protein ligase activity
Summaries
Gene Snapshot
neuralized (neur) encodes an E3 ubiquitin ligase of the RING family. It is part of the Notch signaling pathway, where it is thought to contribute to the endocytosis-dependent activation of the ligand. It also has Notch-independent functions in epithelial morphogenesis. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES -
This group comprises RING domain ubiquitin ligases that do not classify under other groups in FlyBase.
Pathway (FlyBase)
POSITIVE REGULATORS OF NOTCH SIGNALING PATHWAY -
The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Positive regulators of the pathway enhance the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
Protein Function (UniProtKB)
Probable E3 ubiquitin-protein ligase involved in regulation of Notch signaling (PubMed:15760269, PubMed:15829515). May ubiquitinate the intracellular domains of Notch ligands Dl/delta and Ser/serrate, leading to their endocytosis and degradation (PubMed:15760269, PubMed:15829515). Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.
(UniProt, P29503)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
neu: neuralised (J.C. Hall)
Homozygous lethal, with hyperplasia of neural components at the expense of epidermal components as seen in other neurogenic lethal mutations (N, bib, mam, etc.); neu mutations cause especially strong neural hypertrophy; also aberrant imaginal disc development when expressed in mosaic clones (Dietrich and Campos-Ortega, 1984, J. Neurogenet. 1: 315-32). N+ duplications reduce the neu neural hypertrophy, while neu+ duplications have no effect on N defects (De la Concha, Dietrich, Weigel, and Campos-Ortega, 1968, Genetics 118: 499-508).
Summary (Interactive Fly)

cytoplasmic zinc finger signaling protein - neurogenic - promotes or modulates the Notch neurogenic signal at the receptor/ligand level

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\neur for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P29503)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.48

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
neur-RA
FBtr0082003
NM_057304
3992
754
neur-RB
FBtr0082004
NM_169257
3989
753
neur-RC
FBtr0082001
NM_169256
3756
672
neur-RD
FBtr0082002
NM_169255
3753
671
neur-RE
FBtr0300414
NM_001170092
3381
672
Additional Transcript Data and Comments
Reported size (kB)

4.1, 3.7 (northern blot)

(Price et al., 1993)

4.2, 4.0 (northern blot)

(Boulianne et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
neur-PA
FBpp0081481
82.3
754
7.91
P29503
NP_476652
AAF54330
neur-PB
FBpp0081482
82.2
753
7.91
NP_731311
AAF54326
neur-PC
FBpp0081479
72.8
672
7.19
E1JIG1
NP_731310
AAN13407
neur-PD
FBpp0081480
72.6
671
7.19
NP_731309
AAN13406
neur-PE
FBpp0289643
72.8
672
7.19
E1JIG1
NP_001163563
ACZ94860
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

672 aa isoforms: neur-PC, neur-PE
Additional Polypeptide Data and Comments
Reported size (kDa)

753 (aa)

(Boulianne et al., 1993)

754 (aa); 82 (kD predicted)

(Price et al., 1993)

411 (aa)

(Boulianne et al., 1991)
Comments

last few amino acids differ from neur+P754

(FlyBase, 1992-)
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\neur using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.33

Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
indirect flight muscle cell
(Katti et al., 2017)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
mesectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 5
mesoderm | presumptive
(Price et al., 1993)
embryonic stage 5 -- 6
mesectoderm
(Kearney et al., 2004, Boulianne et al., 1991)
embryonic stage 5 -- 7
mesoderm
(Boulianne et al., 1991)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
anterior endoderm anlage
(Fisher et al., 2012)
foregut anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
mesectoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 7 -- 12
epidermoblast

Comment: reference states 3-9 hr AEL

(Boulianne et al., 1991)
neuroblast

Comment: reference states 3-9 hr AEL

(Boulianne et al., 1991)
embryonic stage 8 -- 11
ectoderm
(Boulianne et al., 1991)
embryonic stage 9
ventral neurectoderm
(Price et al., 1993)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
mesectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 10
neuroblast
(Price et al., 1993)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic ganglion mother cell
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
larval lateral VNC glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
stomatogastric nervous system primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
ventral sensory complex anlage
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic central brain surface glial cell
(Fisher et al., 2012)
embryonic stomatogastric nervous system
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
larval lateral VNC surface glial cell
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
late third instar larval stage
external sensory organ precursor cell of wing disc
(Yeh et al., 2000)
wandering third instar larval stage
sensory mother cell of wing disc
(Boulianne et al., 1991)
larval outer optic anlage
(Boulianne et al., 1991)
eye-antennal disc | restricted
(Boulianne et al., 1991)
larval inner optic anlage
(Boulianne et al., 1991)
neuroblast
(Boulianne et al., 1991)
pupal stage P6
eo neuron of mesonotum

Comment: reference states 24 hr APF

(Yeh et al., 2000)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Boulianne et al., 1991)
embryonic stage -- adult stage
(Price et al., 1993)
embryonic stage 1 -- 15

Comment: reference states 0-12 hr AEL

(Price et al., 1993)
organism
(Boulianne et al., 1991)
adult stage | female
(Price et al., 1993)
Additional Descriptive Data

Expression pattern inferred from unspecified enhancer trap line.

(Kearney et al., 2004)

neur expression is undetectable before late third instar, and is first observed in the sensory organ precursors of the wing disc.

(Yeh et al., 2000)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
eye disc
(Lai et al., 2001)
Additional Descriptive Data

The protein can be detected at the plasma membrane and in many intracellular vesicles in eye disc photoreceptors.

(Lai et al., 2001)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Perez-Mockus et al., 2017, Skwarek et al., 2007, Le Borgne and Schweisguth, 2003)
colocalizes_with endosome
inferred from direct assay
(Commisso and Boulianne, 2007)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Le Borgne and Schweisguth, 2003)
located_in plasma membrane
inferred from direct assay
(Commisso and Boulianne, 2007, Skwarek et al., 2007, Yeh et al., 2001, Yeh et al., 2000)
Expression Deduced from Reporters
Reporter: P{GAL4}neurP72
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage & pupal stage
sensory mother cell
(FlyBase, 1992-)
campaniform sensillum
(FlyBase, 1992-)
imaginal disc
(FlyBase, 1992-)
third instar larval stage
ocellus
(FlyBase, 1992-)
sensory mother cell
(FlyBase, 1992-)
eye-antennal disc | restricted
(FlyBase, 1992-)
sensory mother cell of wing disc
(FlyBase, 1992-)
pupal stage
wing vein
(FlyBase, 1992-)
external sensory organ precursor cell
(Bellaiche et al., 2001)
leg | restricted
(Tajiri et al., 2010)
adult stageoogenesis stage S2 -- S14
polar follicle cell
(Besse and Pret, 2003)
Reporter: P{GawB}neurGAL4-A101
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage & P-stage
antennal segment 3 sense organ | precursor
(Jhaveri et al., 2000)
larval stage & pupal stage
sensory mother cell
(Jhaveri et al., 2000)
Johnston organ | precursor
(Jhaveri et al., 2000)
larval stage & pupal stage
sensory mother cell
(FlyBase, 1992-)
campaniform sensillum
(FlyBase, 1992-)
imaginal disc
(FlyBase, 1992-)
third instar larval stage
ocellus
(FlyBase, 1992-)
sensory mother cell
(FlyBase, 1992-)
eye-antennal disc | restricted
(FlyBase, 1992-)
sensory mother cell of wing disc
(FlyBase, 1992-)
prepupal stage P4(i)
proneural cluster of antennal disc | restricted | subset
(Sen et al., 2003)
pupal stage
wing vein
(FlyBase, 1992-)
pupal stage P5(ii)
proneural cluster of antennal disc | restricted | subset
(Sen et al., 2003)
external sensory organ precursor cell IIa
(Sen et al., 2003)
external sensory organ precursor cell IIb
(Sen et al., 2003)
external sensory organ precursor cell IIc
(Sen et al., 2003)
pupal stage P7
macrochaeta | restricted

Comment: reference states 42 hours APF

(Bitan et al., 2010)
adult stage | femaleoogenesis stage S1 -- S4
polar follicle cell | precursor
(Althauser et al., 2005)
adult stage | femaleoogenesis stage S4 -- S5
polar follicle cell
(Althauser et al., 2005)
Reporter: P{GawB}neurNP3291
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
inner layer of the larval mushroom body
(Pauls et al., 2010, Pauls et al., 2010)
outer layer of the larval mushroom body
(Pauls et al., 2010, Pauls et al., 2010)
core layer of the larval mushroom body
(Pauls et al., 2010, Pauls et al., 2010)
adult stage
adult mushroom body dorsal accessory calyx
(Tanaka et al., 2008)
mushroom body beta lobe posterior layer
(Tanaka et al., 2008)
mushroom body alpha lobe posterior layer
(Tanaka et al., 2008)
mushroom body beta lobe surface layer
(Tanaka et al., 2008)
mushroom body alpha lobe surface layer
(Tanaka et al., 2008)
calyx of adult mushroom body
(Tanaka et al., 2008)
alpha/beta Kenyon cell
(Pauls et al., 2010)
alpha/beta surface Kenyon cell
(Flybrain Neuron Database et al., 2018.6.28)
alpha/beta posterior Kenyon cell
(Flybrain Neuron Database et al., 2018.6.28)
Kenyon cell
(Flybrain Neuron Database et al., 2018.6.28)
adult mushroom body alpha-lobe
(Pauls et al., 2010)
adult mushroom body beta-lobe
(Pauls et al., 2010)
Reporter: P{lacW}neurS032812
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval nervous system
(Salzberg et al., 1997)
embryonic/larval midgut
(Salzberg et al., 1997)
embryonic stage 6 -- 9
mesoderm
(Salzberg et al., 1997)
Reporter: P{lacW}neurS097115a
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval nervous system
(Salzberg et al., 1997)
ectoderm
(Salzberg et al., 1997)
Reporter: P{lacW}neurS131505
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Salzberg et al., 1997)
Reporter: P{lArB}neurA101
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage & pupal stage
imaginal disc
(Blair et al., 1992)
sensory mother cell
(Blair et al., 1992)
larval stage & pupal stage
campaniform sensillum
(Blair et al., 1992)
third instar larval stage
sensory mother cell
(Tognon et al., 2016, Garcia-Alonso et al., 1995, Hinz et al., 1994, Skeath and Carroll, 1991)
sensory mother cell of wing disc
(Usui and Kimura, 1992)
eye-antennal disc | restricted
(Garcia-Alonso et al., 1995)
wing disc | restricted
(Neumann and Cohen, 1996)
sensory mother cell of wing disc | subset
(Neumann and Cohen, 1996)
campaniform sensillum of dorsal radius Sc25 | precursor
(Neumann and Cohen, 1996)
campaniform sensillum of anterior crossvein | precursor
(Neumann and Cohen, 1996)
campaniform sensillum L3-2 of wing vein L3 | precursor
(Neumann and Cohen, 1996)
giant sensillum of the dorsal radius | precursor
(Neumann and Cohen, 1996)
campaniform sensillum of dorsal radius Sc12 | precursor
(Neumann and Cohen, 1996)
ocellus
(Garcia-Alonso et al., 1995)
wandering third instar larval stage
sensory mother cell of wing disc
(Tomoyasu et al., 1998)
sensory mother cell
(Tomoyasu et al., 1998)
prepupal stage P4(i)
proneural cluster of antennal disc | restricted | subset
(Sen et al., 2003)
pupal stage
wing vein
(Blair et al., 1992)
sensory mother cell
(Axelrod et al., 1996)
adult stageoogenesis stage S2 -- S14
polar follicle cell
(Besse and Pret, 2003)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\neur in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 82 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 47 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of neur
Transgenic constructs containing regulatory region of neur
Aberrations (Deficiencies and Duplications) ( 9 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | neurogenic phenotype | recessive
lethal | recessive
lethal - all die before end of pupal stage | somatic clone
lethal - all die during embryonic stage (with neur11)
lethal - all die during embryonic stage (with neurnm136)
lethal - all die during embryonic stage | neurogenic phenotype | recessive
lethal - all die during embryonic stage | recessive
partially lethal - majority die, with Scer\GAL429BD
partially lethal - majority die, with Scer\GAL4c355
partially lethal - majority die, with Scer\GAL4dpp.blk1
partially lethal - majority die, with Scer\GAL4hs.2sev
partially lethal - majority die, with Scer\GAL4sca-537.4
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal behavior | male
abnormal behavior | recessive
abnormal cell migration | embryonic stage 10
abnormal locomotor behavior
abnormal memory
abnormal memory, with Scer\GAL4c747
abnormal memory, with Scer\GAL4c747, Scer\GAL80ts.αTub84B
abnormal memory, with Scer\GAL4Mef2.247
abnormal memory | temperature conditional, with Scer\GAL4c747
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4ptc-559.1, neur11
abnormal neuroanatomy, with Scer\GAL4ptc-559.1, neurT42.UAS.Tag:MYC
abnormal neuroanatomy | adult stage
abnormal neuroanatomy | adult stage, with Scer\GAL4ato.3.6
abnormal neuroanatomy | embryonic stage
abnormal neuroanatomy | embryonic stage 11 (with neur1)
abnormal neuroanatomy | embryonic stage 11 (with neur11)
abnormal neuroanatomy | embryonic stage (with neur11)
abnormal neuroanatomy | embryonic stage (with neurnm136)
abnormal planar polarity, with Scer\GAL4Bx-MS1096
abnormal smell perception
increased cell number | cell autonomous | pupal stage | somatic clone
increased cell number | embryonic stage
increased cell number | embryonic stage 10
increased cell number | embryonic stage 11 (with neur1)
increased cell number | embryonic stage 11 (with neur11)
increased cell number | third instar larval stage, with Scer\GAL4Antp-21
increased occurrence of cell division | larval stage, with Scer\GAL4wor.PA
neurogenic phenotype | embryonic stage, with Scer\GAL4neur-GAL4-A101
neurogenic phenotype | embryonic stage | recessive
some die during embryonic stage | recessive
some die during pupal stage | somatic clone
visible
visible, with Scer\GAL429BD
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4c355
visible, with Scer\GAL4da.G32
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4hs.2sev
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4sca-537.4
visible | adult stage, with Scer\GAL4dpp.PU
visible | adult stage, with Scer\GAL4pnr-MD237
visible | somatic clone
wild-type, with Scer\GAL4hs.2sev
wild-type, with Scer\GAL4sca-537.4
wild-type, with Scer\GAL4unspecified
Phenotype manifest in
Allele
adult epidermis, with Scer\GAL4Bx-MS1096
adult head bristle | somatic clone
adult midgut
adult mushroom body alpha-lobe
adult thoracic sensillum, with Scer\GAL4sca-537.4
apterous-expressing neuron of the lateral cluster of the thorax
apterous-expressing neuron of the lateral cluster of the thorax | ectopic
apterous-expressing neuron of the lateral cluster of the thorax Ap4 | increased number
bristle of mesothoracic tergum | absent, with Scer\GAL4pnr-MD237
campaniform sensillum, with Scer\GAL4dpp.blk1
campaniform sensillum of dorsal radius, with Scer\GAL4Bx-MS1096
campaniform sensillum of dorsal radius, with Scer\GAL4dpp.blk1
campaniform sensillum of dorsal radius | ectopic, with Scer\GAL4dpp.blk1
campaniform sensillum of dorsal radius | increased number, with Scer\GAL4Bx-MS1096
chaeta | increased number, with Scer\GAL4pnr-MD237
chemosensory ventral triple row bristle | somatic clone | increased number
cone cell, with Scer\GAL4GMR.PF
cuticle & macrochaeta | somatic clone
dorsal-ventral compartment boundary of the wing disc
dorsocentral bristle, with Scer\GAL4sca-537.4
ectoderm
ellipsoid body
embryonic/larval crystal cell
embryonic/larval dorsal vessel | precursor
embryonic epidermis
embryonic myoblast
embryonic neuroblast | embryonic stage 11 | increased number (with neur1)
embryonic neuroblast | embryonic stage 11 | increased number (with neur11)
enterocyte | somatic clone
eo neuron | somatic clone
exit glial cell
external sensory organ precursor cell | ectopic
external sensory organ precursor cell I | increased number
external sensory organ precursor cell IIa
external sensory organ precursor cell IIb
eye, with Scer\GAL4ey.PS
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4hs.2sev
eye | somatic clone
eye disc, with Scer\GAL4GMR.PF
eye photoreceptor cell & ommatidium | ectopic | somatic clone
eye photoreceptor cell | somatic clone
female germline stem cell | germline clone
germline stem cell | embryonic stage 10
germline stem cell | somatic clone
interommatidial bristle, with Scer\GAL4GMR.PF
interommatidial bristle | ectopic | somatic clone
interommatidial bristle | increased number, with Scer\GAL4GMR.PF
interommatidial bristle | somatic clone
interommatidial bristle | somatic clone | increased number
interstitial cell precursor | embryonic stage 10 | increased number
lamellocyte | increased number | third instar larval stage, with Scer\GAL4Antp-21
larval central brain, with Scer\GAL4wor.PA
larval glial cell
larval nervous system
larval nervous system, with Scer\GAL4neur-GAL4-A101
larval neuroblast, with Scer\GAL4wor.PA
larval somatic muscle cell
larval somatic muscle cell | germline clone
larval ventral nerve cord | embryonic stage (with neur11)
larval ventral nerve cord | embryonic stage (with neurnm136)
lens | somatic clone
lobula columnar neuron LC14, with Scer\GAL4ato.3.6
macrochaeta
macrochaeta, with Scer\GAL4A78
macrochaeta, with Scer\GAL4Bx-MS1096
macrochaeta, with Scer\GAL4neur-GAL4-A101
macrochaeta, with Scer\GAL4sca-537.4
macrochaeta & head, with Scer\GAL4sca-537.4
macrochaeta & mesothoracic tergum | somatic clone
macrochaeta & mesothoracic tergum | supernumerary | somatic clone
macrochaeta | cell autonomous | ectopic | somatic clone
macrochaeta | increased number, with Scer\GAL4Bx-MS1096
macrochaeta | increased number, with Scer\GAL4sca-537.4
macrochaeta | somatic clone
macrochaeta | somatic clone | increased number
mechanosensory ventral triple row bristle | somatic clone
medulla, with Scer\GAL4ato.3.6
mesonotum, with Scer\GAL4pnr-MD237
mesonotum, with Scer\GAL4sca-537.4
microchaeta, with Scer\GAL4Bx-MS1096
microchaeta, with Scer\GAL4sca-537.4
microchaeta & sternite | female
microchaeta & sternite | male
microchaeta | cell autonomous | ectopic | somatic clone
microchaeta | increased number, with Scer\GAL4sca-537.4
microchaeta | somatic clone
microchaeta | somatic clone | increased number
nervous system | ectopic
neuroblast
neuron & eye | supernumerary | somatic clone
neuron & peripheral nervous system
ommatidium, with Scer\GAL4GMR.PF
ommatidium | somatic clone
photoreceptor neuron, with Scer\GAL4GMR.PF
pigment cell | somatic clone
PNS glial cell
presumptive embryonic/larval central nervous system
presumptive embryonic/larval nervous system
presumptive embryonic/larval nervous system, with Scer\GAL4ptc-559.1, neur11
presumptive embryonic/larval nervous system, with Scer\GAL4ptc-559.1, neurT42.UAS.Tag:MYC
presumptive embryonic/larval peripheral nervous system
primary lobe of embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4Antp-21
rhabdomere | cell autonomous | somatic clone
rhabdomere | somatic clone
sensory mother cell
sensory mother cell, with Scer\GAL4sca-537.4
sensory mother cell | cell autonomous | pupal stage | somatic clone | increased number
sensory mother cell | ectopic | somatic clone
sensory mother cell | increased number, with Scer\GAL4Bx-MS1096
sensory mother cell | increased number, with Scer\GAL4sca-537.4
sensory neuron & peripheral nervous system
sternopleural bristle | female
sternopleural bristle | male
thecogen cell | somatic clone
thorax & chaeta | somatic clone
tormogen cell, with Scer\GAL4neur-P72
tormogen cell | increased number, with Scer\GAL4neur-GAL4-A101
tormogen cell | somatic clone
tormogen cell | somatic clone | increased number
trichogen cell, with Scer\GAL4neur-P72
trichogen cell | ectopic | somatic clone
triple row of wing sensilla | somatic clone
wing, with Scer\GAL4Bx-MS1096
wing margin, with Scer\GAL4Bx-MS1096
wing margin, with Scer\GAL4dpp.blk1
wing margin, with Scer\GAL4dpp.PU
wing margin, with Scer\GAL4Ser.PGF
wing margin, with Scer\GAL4VMQ
wing margin | distal, with Scer\GAL4dpp.blk1
wing margin bristle | ectopic | somatic clone
wing margin bristle | somatic clone
wing vein
wing vein, with Scer\GAL429BD
wing vein, with Scer\GAL4A78
wing vein, with Scer\GAL4Bx-MS1096
wing vein, with Scer\GAL4c355
wing vein, with Scer\GAL4dpp.blk1
wing vein, with Scer\GAL4VMQ
wing vein | ectopic | somatic clone
wing vein L2, with Scer\GAL4da.G32
wing vein L3, with Scer\GAL4da.G32
wing vein L3, with Scer\GAL4dpp.blk1
wing vein L4, with Scer\GAL4da.G32
wing vein L5, with Scer\GAL4da.G32
wing vein L5, with Scer\GAL4VMQ
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (23)
Hsap\NEURL1B
13 of 14
Yes
Yes
Hsap\NEURL1
12 of 14
No
Yes
Hsap\NEURL3
6 of 14
No
Yes
Hsap\NEURL2
2 of 14
No
No
Hsap\NEURL4
2 of 14
No
No
Hsap\BIRC3
1 of 14
No
No
Hsap\HLTF
1 of 14
No
No
Hsap\MGRN1
1 of 14
No
No
1  
Hsap\MIB1
1 of 14
No
No
6  
Hsap\MUL1
1 of 14
No
No
Hsap\RFFL
1 of 14
No
No
Hsap\RLIM
1 of 14
No
No
1  
Hsap\RNF5
1 of 14
No
No
1  
Hsap\RNF8
1 of 14
No
Yes
Hsap\RNF13
1 of 14
No
No
1  
Hsap\RNF34
1 of 14
No
No
1  
Hsap\RNF141
1 of 14
No
Yes
Hsap\RNF145
1 of 14
No
No
Hsap\RNF157
1 of 14
No
No
Hsap\RNF167
1 of 14
No
No
Hsap\RNF185
1 of 14
No
No
2  
Hsap\TRIM26
1 of 14
No
Yes
Hsap\TRIM31
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (25)
Rnor\Neurl1b
13 of 14
Yes
Yes
Rnor\Neurl1
12 of 14
No
Yes
Rnor\Neurl3
5 of 14
No
Yes
Rnor\Neurl2
2 of 14
No
No
Rnor\Neurl4
2 of 14
No
No
Rnor\Birc2
1 of 14
No
No
Rnor\Cblc
1 of 14
No
No
Rnor\Lonrf2
1 of 14
No
No
Rnor\Mex3c
1 of 14
No
No
Rnor\Mex3d
1 of 14
No
No
Rnor\Mgrn1
1 of 14
No
No
Rnor\Mul1
1 of 14
No
No
Rnor\Rffl
1 of 14
No
No
Rnor\Rlim
1 of 14
No
No
Rnor\Rnf5
1 of 14
No
No
Rnor\Rnf13
1 of 14
No
No
Rnor\Rnf34
1 of 14
No
No
Rnor\Rnf114
1 of 14
No
Yes
Rnor\Rnf145
1 of 14
No
No
Rnor\Rnf157
1 of 14
No
No
Rnor\Rnf167
1 of 14
No
No
Rnor\Rnf185
1 of 14
No
No
Rnor\Trim26
1 of 14
No
Yes
Rnor\Trim31
1 of 14
No
Yes
Rnor\Xiap
1 of 14
No
No
Mus musculus (laboratory mouse) (24)
Mmus\Neurl1b
13 of 14
Yes
Yes
Mmus\Neurl1a
12 of 14
No
Yes
Mmus\Neurl3
4 of 14
No
Yes
Mmus\Neurl2
2 of 14
No
No
Mmus\Neurl4
2 of 14
No
No
Mmus\Dtx3l
1 of 14
No
Yes
Mmus\Gm9008
1 of 14
No
No
Mmus\Hltf
1 of 14
No
No
Mmus\Mgrn1
1 of 14
No
No
Mmus\Mib1
1 of 14
No
No
Mmus\Mul1
1 of 14
No
No
Mmus\Rffl
1 of 14
No
No
Mmus\Rlim
1 of 14
No
No
Mmus\Rnf5
1 of 14
No
No
Mmus\Rnf13
1 of 14
No
No
Mmus\Rnf26
1 of 14
No
No
Mmus\Rnf34
1 of 14
No
No
Mmus\Rnf114
1 of 14
No
Yes
Mmus\Rnf145
1 of 14
No
No
Mmus\Rnf157
1 of 14
No
No
Mmus\Rnf167
1 of 14
No
No
Mmus\Rnf185
1 of 14
No
No
Mmus\Trim26
1 of 14
No
No
Mmus\Xiap
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\neurl1
10 of 13
Yes
Yes
Xtro\neurl1b
8 of 13
No
Yes
Xtro\neurl3
4 of 13
No
Yes
Xtro\abcc2
1 of 13
No
No
Xtro\mex3a
1 of 13
No
No
Xtro\neurl4
1 of 13
No
No
Xtro\rlim
1 of 13
No
No
Xtro\rnf4
1 of 13
No
No
Xtro\rnf26
1 of 13
No
No
Xtro\rnf34
1 of 13
No
No
Xtro\rnf180
1 of 13
No
Yes
Xtro\uhrf2
1 of 13
No
Yes
Danio rerio (Zebrafish) (27)
Drer\neurl1aa
12 of 14
Yes
Yes
Drer\neurl1ab
11 of 14
No
Yes
Drer\neurl1b
11 of 14
No
Yes
Drer\neurl2
2 of 14
No
No
Drer\neurl4
2 of 14
No
No
Drer\birc2
1 of 14
No
No
Drer\hltf
1 of 14
No
No
Drer\lnx1
1 of 14
No
No
Drer\LOC402879
1 of 14
No
No
Drer\LOC101885672
1 of 14
No
Yes
Drer\lrsam1
1 of 14
No
Yes
Drer\mgrn1a
1 of 14
No
No
Drer\mgrn1b
1 of 14
No
No
Drer\mib1
1 of 14
No
No
Drer\mul1a
1 of 14
No
No
Drer\mul1b
1 of 14
No
No
Drer\rffl
1 of 14
No
No
Drer\rnf5
1 of 14
No
No
Drer\rnf34a
1 of 14
No
No
Drer\rnf34b
1 of 14
No
No
Drer\rnf38
1 of 14
No
No
Drer\rnf141
1 of 14
No
Yes
Drer\rnf145b
1 of 14
No
No
Drer\rnf157
1 of 14
No
No
Drer\rnf185
1 of 14
No
No
Drer\trim35-4
1 of 14
No
Yes
Drer\zgc:171740
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\F10D7.5
13 of 14
Yes
Yes
Cele\C11H1.3
1 of 14
No
No
Cele\C32D5.11
1 of 14
No
No
Cele\rnf-5
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (12)
Agam\AgaP_AGAP001999
11 of 12
Yes
Yes
Agam\AgaP_AGAP009070
2 of 12
No
No
Agam\AgaP_AGAP011965
2 of 12
No
No
Agam\AgaP_AGAP000928
1 of 12
No
No
Agam\AgaP_AGAP005053
1 of 12
No
No
Agam\AgaP_AGAP005287
1 of 12
No
No
Agam\AgaP_AGAP005643
1 of 12
No
No
Agam\AgaP_AGAP005955
1 of 12
No
No
Agam\AgaP_AGAP006041
1 of 12
No
No
Agam\AgaP_AGAP006730
1 of 12
No
No
Agam\IAP7
1 of 12
No
No
Agam\IAP8
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (36)
Atha\AT5G04460
4 of 13
Yes
Yes
Atha\AT2G27950
3 of 13
No
Yes
Atha\AT1G30860
2 of 13
No
Yes
Atha\AT4G20160
2 of 13
No
Yes
Atha\AT4G24204
2 of 13
No
No
Atha\EDA18
2 of 13
No
Yes
Atha\APD1
1 of 13
No
No
Atha\APD2
1 of 13
No
No
Atha\APD3
1 of 13
No
No
Atha\APD4
1 of 13
No
No
Atha\AT1G19310
1 of 13
No
No
Atha\AT1G32530
1 of 13
No
Yes
Atha\AT1G62370
1 of 13
No
Yes
Atha\AT1G74990
1 of 13
No
No
Atha\AT2G23780
1 of 13
No
No
Atha\AT2G35330
1 of 13
No
Yes
Atha\AT2G37580
1 of 13
No
Yes
Atha\AT2G42030
1 of 13
No
No
Atha\AT2G44410
1 of 13
No
No
Atha\AT3G58030
1 of 13
No
No
Atha\AT4G39050
1 of 13
No
No
Atha\AT5G05130
1 of 13
No
No
Atha\AT5G23110
1 of 13
No
Yes
Atha\BRG1
1 of 13
No
Yes
Atha\COP1
1 of 13
No
No
Atha\DAL1
1 of 13
No
No
Atha\Hrd1A
1 of 13
No
No
Atha\LOG2
1 of 13
No
No
Atha\LUL2
1 of 13
No
No
Atha\LUL4
1 of 13
No
No
Atha\PEX10
1 of 13
No
No
Atha\RGLG1
1 of 13
No
Yes
Atha\RMA1
1 of 13
No
No
Atha\RMA2
1 of 13
No
No
Atha\RMA3
1 of 13
No
No
Atha\XBAT35
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\IRC20
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\brl2
1 of 12
Yes
No
Spom\slx8
1 of 12
Yes
No
Spom\SPBC14F5.10c
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:neur. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (15)
CG3894
3 of 13
Neurl4
3 of 13
Cbl
1 of 13
CG8141
1 of 13
CG11360
1 of 13
CG17019
1 of 13
CG32847
1 of 13
CG34308
1 of 13
Diap1
1 of 13
Mul1
1 of 13
Pex10
1 of 13
sordd1
1 of 13
sordd2
1 of 13
Topors
1 of 13
Traf6
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    neurHD_CFD01179
    model of  intestinal cancer
    CEC with Spyo\Cas9UAS.uM.-FRT
    (Bahuguna et al., 2021)
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    neurΔRING.UAS.EGFP
    exacerbates  Parkinson's disease 8
    modeled by Hsap\LRRK2UAS.cVa
    (Imai et al., 2015)
    modeled by Hsap\LRRK2RG.UAS
    (Imai et al., 2015)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NEURL1B; neuralized E3 ubiquitin protein ligase 1B
    13 of 14
    615893
        NEURL1; neuralized E3 ubiquitin protein ligase 1
        12 of 14
        603804
            NEURL3; neuralized E3 ubiquitin protein ligase 3
            6 of 14
            617206
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                neur
                anti tag coimmunoprecipitation, anti tag western blot, two hybrid
                (Liu et al., 2012)
                neur - BobA
                two hybrid
                (Bardin and Schweisguth, 2006)
                neur - BobB
                two hybrid
                (Bardin and Schweisguth, 2006)
                neur - BobC
                two hybrid
                (Bardin and Schweisguth, 2006)
                neur - Brd
                two hybrid
                (Bardin and Schweisguth, 2006)
                neur - CG10947
                two hybrid
                (Hu et al., 2017.6.13)
                neur - Delta
                anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot, anti bait coimmunoprecipitation, enzymatic study
                (Liu et al., 2012, Daskalaki et al., 2011, Fontana and Posakony, 2009, Commisso and Boulianne, 2007, Skwarek et al., 2007, Pitsouli and Delidakis, 2005)
                neur - E(spl)m4-BFM
                two hybrid, pull down, western blot
                (Fontana and Posakony, 2009, Bardin and Schweisguth, 2006)
                neur - E(spl)m6-BFM
                two hybrid
                (Bardin and Schweisguth, 2006)
                neur - E(spl)mα-BFM
                pull down, western blot, two hybrid
                (Fontana and Posakony, 2009, Bardin and Schweisguth, 2006)
                neur - Ocho
                two hybrid
                (Bardin and Schweisguth, 2006)
                neur - Ser
                anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot
                (Liu et al., 2012, Glittenberg et al., 2006, Pitsouli and Delidakis, 2005)
                neur - Tom
                anti tag coimmunoprecipitation, anti tag western blot, two hybrid, nuclear magnetic resonance, isothermal titration calorimetry, predetermined participant
                (He et al., 2009, Bardin and Schweisguth, 2006)
                neur - sdt
                anti tag coimmunoprecipitation, anti tag western blot
                (Perez-Mockus et al., 2017)
                Summary of Genetic Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                neur
                enhanceable
                Delta
                (Pitsouli and Delidakis, 2005)
                neur
                suppressible
                eff
                (Lai et al., 2001)
                neur
                suppressible
                H
                (Dietrich and Campos-Ortega, 1984)
                neur
                enhanceable
                HERC2
                (Imai et al., 2015)
                neur
                suppressible
                Lrrk
                (Imai et al., 2015)
                neur
                enhanceable
                mib1
                (Pitsouli and Delidakis, 2005)
                neur
                suppressible
                mib1
                (Lai et al., 2005)
                neur
                enhanceable
                Neurl4
                (Imai et al., 2015)
                neur
                enhanceable
                Ser
                (Pitsouli and Delidakis, 2005)
                neur
                suppressible
                Tom
                (Bardin and Schweisguth, 2006)
                neur
                suppressible
                α4GT1
                (Hamel et al., 2010)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Brd
                enhanceable
                neur
                (Leviten and Posakony, 1996)
                Delta
                suppressible
                neur
                (Imai et al., 2015)
                Delta
                enhanceable
                neur
                (Pitsouli and Delidakis, 2005, Lai and Rubin, 2001)
                fru
                enhanceable
                neur
                (Goto et al., 2011)
                H
                enhanceable
                neur
                (Lai and Rubin, 2001)
                H
                suppressible
                neur
                (Johannes and Preiss, 2002)
                lqf
                enhanceable
                neur
                (Overstreet et al., 2004, Tian et al., 2004)
                mib1
                suppressible
                neur
                (Lai et al., 2005, Le Borgne et al., 2005)
                N
                enhanceable
                neur
                (Lai and Rubin, 2001)
                Rala
                enhanceable
                neur
                (Cho and Fischer, 2011)
                Ret
                enhanceable
                neur
                (Read et al., 2005)
                Ret
                suppressible
                neur
                (Read et al., 2005)
                spdo
                suppressible
                Delta|neur
                (Babaoglan et al., 2009)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                FlyBase
                External Links
                External Data
                Linkouts
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                Class of Gene
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map
                3-48
                Cytogenetic map
                85C2-85C3
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                85C2-85C3
                Limits computationally determined from genome sequence between P{lacW}l(3)L4740L4740 and P{EP}D1EP473
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                85C3-85C4
                (determined by in situ hybridisation)
                (Ranz et al., 2001)
                85C9-85C10
                (determined by in situ hybridisation)
                (Spradling et al., 1999)
                85C-85C
                (determined by in situ hybridisation) 85C7--11 (determined by in situ hybridisation) 85C9--10 (determined by in situ hybridisation) 85C9--15 (determined by in situ hybridisation)
                (Szeged Stock Center, 1998-)
                85C-85C
                (determined by in situ hybridisation)
                (Salzberg et al., 1997, Price et al., 1993)
                85C9-85C10
                (determined by in situ hybridisation) 85C9--15 (determined by in situ hybridisation) 85C (determined by in situ hybridisation)
                (Deak et al., 1997)
                85C4-85C5
                (determined by in situ hybridisation)
                (Salzberg et al., 1994)
                68A4-68A5
                85D1--27
                (BDGP Project Members, 1994-1999)
                86C1-86C8
                (determined by in situ hybridisation)
                (Boulianne et al., 1993)
                85D-85D
                (determined by in situ hybridisation)
                (Cooley et al., 1988)
                Experimentally Determined Recombination Data
                Location

                3-48

                (FlyBase, 2016)

                3-45.8

                (Comeron et al., 2012)

                3-50

                (Tearle and Nusslein-Volhard, 1987)

                3-48.5

                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (38)
                Genomic Clones (20)
                cDNA Clones (67)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Lai et al., 2001)
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      Loss of one copy of neur results in significant long-term memory impairment, whereas overexpression of neur in the peripheral neurons of the α/β loves of the adult mushroom bodies results in a dosage-dependent enhancement of long-term memory.

                      (Pavlopoulos et al., 2008)

                      neur overexpression in the mushroom bodies enhances long-term memory but not anaesthesia-resistant memory.

                      (Pavlopoulos et al., 2008)

                      neur contains a phosphoinositide-binding motif that is required for neur-mediated endocytosis of Dl protein downstream of Dl ubiquitination.

                      (Skwarek et al., 2007)

                      Expression is enriched in embryonic gonads.

                      (Shigenobu et al., 2006)

                      neur is required for both germline stem cell maintenance and gonial cell viability.

                      (Terry et al., 2006)

                      The neur product regulates the spdo protein localization.

                      (Roegiers et al., 2005)

                      Ectopic expression of neur can substitute functionally for the absence of mib1 activity.

                      (Wang and Struhl, 2005)

                      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                      (Kiger et al., 2003)

                      neur is required for the socket/shaft and neuron/sheath fate decisions and acts in the pIIb cell to specify the pIIa cell.

                      (Le Borgne and Schweisguth, 2003)

                      The internalization of Dl is drastically reduced in neur mutant cells, indicating that neur is required for the endocytosis of Dl.

                      (Le Borgne and Schweisguth, 2003)

                      neur has a role in the reception of the lateral inhibitory signal during peripheral neurogenesis.

                      (Lai and Rubin, 2001)

                      neur has a role in N-controlled processes during eye development.

                      (Lai and Rubin, 2001)

                      neur positively regulates the N pathway by promoting the endocytosis and degradation of Dl.

                      (Lai et al., 2001)

                      Subcellular localization and steady state levels of Dl are altered in neur mutants.

                      (Lai et al., 2001)

                      neur is involved in the control of Dl endocytosis and steady state levels.

                      (Pavlopoulos et al., 2001)

                      Dl endocytosis and steady state levels are decreased in neur mutant cells.

                      (Pavlopoulos et al., 2001)

                      The RING finger domain of neur acts as an E3 ubiquitin ligase in vitro.

                      (Yeh et al., 2001)

                      neur has a function in sensory organ development. This may be to affect the ability of cells to receive N-Dl signals and thus modulate the neurogenic activity that allows for the specification of non-neuronal fates in the sense organ.

                      (Yeh et al., 2000)

                      Mosaic analysis demonstrates that neur is required in a cell autonomous manner for the selection of the sensory organ precursor from the proneural cluster for the determination of the sensory organ precursor progeny cell fates.

                      (Feger et al., 1995)

                      Alleles of bib and neur show no interaction with da in ovary development.

                      (Cummings and Cronmiller, 1994)

                      Mutation in neur affects sensory organ precursor formation.

                      (Salzberg et al., 1994)

                      neur is required for PNS development in the embryo.

                      (Salzberg et al., 1994)

                      Comparison of D.melanogaster and D.virilis show that it is possible to identify key functional regions of the neur protein by interspecific comparison.

                      (Zhou and Boulianne, 1994)

                      neur is a neurogenic gene required initially to ensure the correct number of PNS precursors. neur is not required for the late epidermal maintenance function.

                      (Bodmer et al., 1993)

                      Molecular analysis of neur indicates a DNA binding function for the gene product.

                      (Price et al., 1993)

                      The embryonic phenotype of neurogenic mutations was examined in most tissues using Ecol\lacZ enhancer trap lines. All alleles examined show defects in many organs from all three germ layers. At least for ectodermally and endodermally derived tissues, neurogenic gene function is primarily involved in interactions among cells that need to acquire or maintain an epithelial phenotype.

                      (Hartenstein et al., 1992)

                      neur is needed for proper mesoderm differentiation prior to the onset of nau expression: mutant alleles cause hypertrophy in nau expressing cells.

                      (Corbin et al., 1991)

                      Genetic analysis demonstrates that Dl, neur, E(spl), HLHm5, HLHm7 and m4 are functionally related. Spatial distribution of mRNA in neurogenic mutant embryos suggests that some of the functional interactions take place at the transcriptional level.

                      (Godt et al., 1991)

                      Ecol\lacZ reporter gene constructs demonstrate that neurogenic loci are required to restrict the number of competent cells that will become sensory mother cells, SMCs.

                      (Goriely et al., 1991)

                      Mutations of mam, bib and neur in an heterozygous condition had no effect on the expression of NAx-59d or NAx-59b except when coupled in cis with Nfa-g. The neurogenic mutations suppress the wing venation phenotype of N.

                      (Portin and Rantanen, 1991)

                      neur mutants show no interaction with dx.

                      (Xu and Artavanis-Tsakonas, 1990)

                      Both neur and mam serve as hotspots for insertion of P{lacW} enhancer trap elements.

                      (Bier et al., 1989)

                      Neural hyperplasia, caused by mutations in neu, can be prevented by the presence of another neurogenic mutation.

                      (Brand and Campos-Ortega, 1988)

                      Increasing number of wild type copies of neur does not modify the bib phenotype. H2 causes reduction of neural hyperplasia due to homozygosity for neur- alleles. N+ duplications reduce the neur neural hypertrophy, while neur+ duplications have no effect on N defects.

                      (de la Concha et al., 1988)

                      neu mutants display no ventral cuticle and hypertrophy of the central nervous system.

                      (Jurgens et al., 1984)
                      Relationship to Other Genes
                      Source for database merge of

                      Source for merge of: neur BEST:LD21494

                      (Rana, 2004.7.8)
                      Additional comments
                      Nomenclature History
                      Source for database identify of
                      Nomenclature comments
                      Etymology
                      Synonyms and Secondary IDs (19)
                      Reported As
                      Symbol Synonym
                      0328/12
                      (Deak et al., 1997)
                      0971/15
                      (Deak et al., 1997)
                      1293/09
                      (Deak et al., 1997)
                      1315/05
                      (Deak et al., 1997)
                      BEST:LD21494
                      CG11988
                      (Schertel et al., 2013, Ni et al., 2011.7.19, Ying et al., 2011, Aerts et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Perkins et al., 2009.1.15, Quinones-Coello, 2007, Quinones-Coello, 2007, Molnar et al., 2006, Norga et al., 2003)
                      Neu
                      (Hossain et al., 2023)
                      Neur
                      (Papagiannouli, 2022, Bellec et al., 2021, Piedade and Famulski, 2021, Reiff et al., 2021, Bahrampour and Thor, 2020, Chaturvedi et al., 2017, Gilmour et al., 2017, Loubéry et al., 2017, Perez-Mockus et al., 2017, Bandyopadhyay et al., 2016, Derivery et al., 2015, Langen et al., 2013, Perdigoto and Bardin, 2013, Giagtzoglou et al., 2012, Kelsom and Lu, 2012, Rincon-Arano et al., 2012, Song and Lu, 2012, Benhra et al., 2011, Daskalaki et al., 2011, Furman and Bukharina, 2011, Fiuza et al., 2010, Mudiganti et al., 2010, Babaoglan et al., 2009, He et al., 2009, Commisso and Boulianne, 2008, Norgate et al., 2007, Polo and Di, 2006, Anonymous, 2005, Fichelson et al., 2005, Bardin and Schweisguth, 2004)
                      l(3)j6B12
                      l(3)j9B8
                      l(3)j9B9
                      l(3)j9C8
                      l(3)neo37
                      neu
                      (Wieschaus and Nüsslein-Volhard, 2016, Salzer et al., 2010, Stephan et al., 2008, Ohlstein and Spradling, 2007, Balakireva et al., 2006, Gonzalez-Gaitan and Stenmark, 2003, Micchelli et al., 2003, Sen et al., 2003, Lai and Rubin, 2001, Lai and Rubin, 2001, Riede, 2001, Yeh et al., 2001, Baeg and Perrimon, 2000, Dobens and Raftery, 2000, Jhaveri et al., 2000, Jhaveri et al., 2000, Pages and Kerridge, 2000, Yeh et al., 2000, Yeh et al., 2000, Jack and Myette, 1999, Rusconi and Corbin, 1999, Wu and Rao, 1999, Yeh et al., 1999, Yuan et al., 1999, Zhang et al., 1999, Rusconi and Corbin, 1998, Yeh et al., 1998, Doherty et al., 1997, Jagla et al., 1997, Sonnenfeld et al., 1997, Hassan and Vassin, 1996, Leviten and Posakony, 1996, Lewis, 1996, Naemsch and Boulianne, 1996, Salzberg and Bellen, 1996, Yeh and Boulianne, 1996, Bang et al., 1995, Feger et al., 1995, Jennings et al., 1995, Lord et al., 1995, Mackay, 1995, Sturtevant and Bier, 1995, Wilkins, 1995, Couso and Martinez Arias, 1994, Hoch et al., 1994, Lewis and Crews, 1994, Muskavitch, 1994, Nelson and Laughon, 1994, Ruohola-Baker et al., 1994, Salzberg et al., 1994, Watson et al., 1994, Yamaguchi et al., 1994, Zhou and Boulianne, 1994, Bate et al., 1993, Blair, 1993, Boulianne, 1993.7.27, Boulianne et al., 1993, Campos-Ortega, 1993, Campos-Ortega, 1993, Coyle-Thompson and Banerjee, 1993, Dickson and Hafen, 1993, Jan and Jan, 1993, Kooh et al., 1993, Martinez Arias, 1993, Miklos, 1993, Noll et al., 1993, Price, 1993.7.27, Price and Laughon, 1993, Price et al., 1993, Skaer, 1993, Boulianne, 1992.1.13, Hartenstein et al., 1992, Skeath and Carroll, 1992, Woods and Bryant, 1992, Basler and Hafen, 1991, Corbin et al., 1991, Godt et al., 1991, Held, 1991, Campos-Ortega and Knust, 1990, Jan and Jan, 1990, Vaessin et al., 1990, Xu and Artavanis-Tsakonas, 1990, Xu et al., 1990, de la Concha et al., 1988, Tearle and Nusslein-Volhard, 1987, Dietrich and Campos-Ortega, 1984, Jurgens et al., 1984)
                      neur
                      (Sood et al., 2024, Pelletier et al., 2023, Troost et al., 2023, Lacoste et al., 2022, Planelles-Herrero et al., 2022, Simões et al., 2022, Vuong and Mlodzik, 2022, Bahuguna et al., 2021, Houssin et al., 2021, Parkhitko et al., 2021, Port et al., 2020, Rust et al., 2020, Stathopoulos and Newcomb, 2020, Falo-Sanjuan et al., 2019, Guo et al., 2019, Bellec et al., 2018, Contreras et al., 2018, Kavaler et al., 2018, Miller and Posakony, 2018, Salazar and Yamamoto, 2018, Yamakawa et al., 2018, Bhattacharya et al., 2017, Hu et al., 2017.6.13, Kojima, 2017, Langridge and Struhl, 2017, Perez-Mockus et al., 2017, Shukla et al., 2017, Trylinski et al., 2017, Ayeni et al., 2016, Blick et al., 2016, Nagel et al., 2016, Baëza et al., 2015, Bivik et al., 2015, Gene Disruption Project members, 2015-, Kidd et al., 2015, Patel et al., 2015, Shahab et al., 2015, Siudeja et al., 2015, Sun et al., 2015, Bischof, 2014.10.20, Miller et al., 2014, Neville et al., 2014, Zacharioudaki and Bray, 2014, Jauffred et al., 2013, Schertel et al., 2013, Webber et al., 2013, Couturier et al., 2012, Liu et al., 2012, Ulvklo et al., 2012, Zacharioudaki et al., 2012, Benhra et al., 2011, Bhat et al., 2011, Cho and Fischer, 2011, Du et al., 2011, Goto et al., 2011, Levis et al., 2011.12.16, Mukherjee et al., 2011, Seong et al., 2011, Takemura and Adachi-Yamada, 2011, Weake et al., 2011, Weinmaster and Fischer, 2011, Yamasaki et al., 2011, Aerts et al., 2010, Bardin et al., 2010, Benhra et al., 2010, Buffin and Gho, 2010, Hamel et al., 2010, Kitadate and Kobayashi, 2010, Liu et al., 2010, Monastirioti et al., 2010, Mukai et al., 2010, Robinett et al., 2010, Salzer et al., 2010, Tajiri et al., 2010, Vachias et al., 2010, Chanet et al., 2009, Fontana and Posakony, 2009, Krejcí et al., 2009, Liu et al., 2009, Miller et al., 2009, Parks and Muskavitch, 2009.2.3, Yamamoto et al., 2009, Eun et al., 2008, Miller and Posakony, 2008, Pavlopoulos et al., 2008, Rollmann et al., 2008, Small et al., 2008, Weber, 2008.12.10, Yamamoto et al., 2008, Assa-Kunik et al., 2007, Commisso and Boulianne, 2007, Magalhaes et al., 2007, Nguyen et al., 2007, Omel'yanchuk et al., 2007, Peng et al., 2007, Quinones-Coello, 2007, Quinones-Coello, 2007, Skwarek et al., 2007, Weiler, 2007, Yi et al., 2007, Bardin and Schweisguth, 2006, Bernard et al., 2006, del Alamo and Mlodzik, 2006, Kuo et al., 2006, Molnar et al., 2006, Mosimann et al., 2006, Sandmann et al., 2006, Shigenobu et al., 2006, Terry et al., 2006, Ward et al., 2006, Emery et al., 2005, Jafar-Nejad et al., 2005, Jafar-Nejad et al., 2005, Macdonald and Long, 2005, Reeves and Posakony, 2005, Roegiers et al., 2005, Kamimura et al., 2004, Li and Baker, 2004, Wang and Struhl, 2004)
                      neuralized
                      (Martin, 2020, Edwards et al., 2006)
                      Name Synonyms
                      Neuralised
                      (Zacharioudaki and Bray, 2014, Kile et al., 2002)
                      Neuralized
                      (Pinot and Le Borgne, 2024, Sachan et al., 2024, Bandyopadhyay et al., 2016, Schweisguth, 2015, Charng et al., 2014, Kelsom and Lu, 2012, Song and Lu, 2012, Benhra et al., 2011, Bhat et al., 2011, Daskalaki et al., 2011, Furman and Bukharina, 2011, Benhra et al., 2010, Fiuza et al., 2010, Hamel et al., 2010, Andrews et al., 2009, Chanet et al., 2009, He et al., 2009, Miller et al., 2009, Benetka et al., 2008, Fontana and Posakony, 2008, Bardin and Schweisguth, 2007, Commisso and Boulianne, 2007, Nguyen et al., 2007, Skwarek et al., 2007, Delwig et al., 2006, De Renzis et al., 2006, Glittenberg et al., 2006, Holley, 2006, Somers and Chia, 2005, Kadesch, 2004, Li and Baker, 2004)
                      neuralised
                      (Lopez-Schier, 2003)
                      neuralized
                      (Ng et al., 2019, Salazar and Yamamoto, 2018, Schwartz and Rhiner, 2018, Wieschaus and Nüsslein-Volhard, 2016, Miller et al., 2014, Cohen et al., 2011, Miura, 2011, Takemura and Adachi-Yamada, 2011, Weinmaster and Fischer, 2011, Bardin et al., 2010, Buffin and Gho, 2010, Kitadate and Kobayashi, 2010, Mukai et al., 2010, Robinett et al., 2010, Salzer et al., 2010, Tajiri et al., 2010, Vachias et al., 2010, Babaoglan et al., 2009, Edwards et al., 2009, Rajan et al., 2009, Yamamoto et al., 2009, Eun et al., 2008, Miller and Posakony, 2008, Pavlopoulos et al., 2008, Rollmann et al., 2008, Small et al., 2008, Yamamoto et al., 2008, Ayyar et al., 2007, Commisso and Boulianne, 2007, Ohlstein and Spradling, 2007, Omel'yanchuk et al., 2007, Vachias et al., 2007, Zeitouni et al., 2007, Edwards et al., 2006, Mosimann et al., 2006, Sambandan et al., 2006, Terry et al., 2006, Roegiers et al., 2005, Micchelli et al., 2003, Price, 1993)
                      Secondary FlyBase IDs
                      • FBgn0011395
                      • FBgn0011419
                      • FBgn0011420
                      • FBgn0011422
                      • FBgn0011470
                      • FBgn0046269
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 104 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      FlyMine - An integrated database for Drosophila genomics
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      PDB - An information portal to biological macromolecular structures
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                      MIST (genetic) - An integrated Molecular Interaction Database
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                      References (514)