FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Dop1R1
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General Information
Symbol
Dmel\Dop1R1
Species
D. melanogaster
Name
Dopamine 1-like receptor 1
Annotation Symbol
CG9652
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011582
Gene Model Status
Current
Stock Availability
69 publicly available
Gene Summary
Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role in restoring dopamine homeostasis. (UniProt, P41596)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

DopR, DopR1, dDA1, dumb, DA1

Key Links
Genomic Location
Cytogenetic map
88A10-88A12
Sequence location
Recombination map
3-54
RefSeq locus
NT_033777 REGION:14165379..14214810
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (28 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables dopamine neurotransmitter receptor activity, coupled via Gs
inferred from mutant phenotype
(Sugamori et al., 1995)
inferred from direct assay
(Gotzes et al., 1994)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables dopamine neurotransmitter receptor activity
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
enables G protein-coupled receptor activity
inferred from electronic annotation with InterPro:IPR000276
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity
(Radford et al., 2002)
enables G protein-coupled serotonin receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000664111
(GO Reference Genome Project, 2011-)
enables neurotransmitter receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000664111
(GO Reference Genome Project, 2011-)
Biological Process (20 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-activating dopamine receptor signaling pathway
inferred from direct assay
(Gotzes et al., 1994)
involved_in associative learning
inferred from mutant phenotype
(Seugnet et al., 2008, Kim et al., 2007)
involved_in cellular response to sucrose stimulus
inferred from direct assay
(Inagaki et al., 2012)
involved_in learning
inferred from mutant phenotype
(Keleman et al., 2012)
involved_in memory
inferred from mutant phenotype
(Seugnet et al., 2008, Kim et al., 2007)
involved_in olfactory behavior
inferred from mutant phenotype
(Noyes and Davis, 2023)
involved_in olfactory learning
inferred from mutant phenotype
(Noyes and Davis, 2023, Selcho et al., 2009)
involved_in regulation of olfactory learning
inferred from mutant phenotype
(Liu et al., 2009)
involved_in regulation of presynaptic cytosolic calcium ion concentration
inferred from mutant phenotype
(Cohn et al., 2015)
involved_in response to odorant
inferred from mutant phenotype
(Cohn et al., 2015)
involved_in response to starvation
inferred from mutant phenotype
(Inagaki et al., 2012)
involved_in response to sucrose
inferred from mutant phenotype
(Inagaki et al., 2012)
involved_in thermosensory behavior
inferred from mutant phenotype
(Bang et al., 2011)
involved_in thermotaxis
inferred from mutant phenotype
(Bang et al., 2011)
involved_in visual learning
inferred from mutant phenotype
(Gotzes et al., 1994)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN008610711
(GO Reference Genome Project, 2011-)
involved_in chemical synaptic transmission
inferred from biological aspect of ancestor with PANTHER:PTN000664111
(GO Reference Genome Project, 2011-)
involved_in G protein-coupled dopamine receptor signaling pathway
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
inferred from biological aspect of ancestor with PANTHER:PTN000664111
(GO Reference Genome Project, 2011-)
involved_in G protein-coupled receptor signaling pathway
inferred from electronic annotation with InterPro:IPR000276
(InterPro Project Members, 2004-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in dendrite
inferred from biological aspect of ancestor with PANTHER:PTN000664111
(GO Reference Genome Project, 2011-)
located_in membrane
inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR017452
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000664111
(GO Reference Genome Project, 2011-)
located_in plasma membrane
inferred from sequence model
(Gotzes et al., 1994)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor 1 family. (P41596)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
DOPAMINE RECEPTORS -
Dopamine GPCRs are Class A GPCRs. Dopamine is a neurotransmitter involved in a variety of behavioural and physiological functions such as memory, arousal and mating behaviour. (Adapted from PMID:17088868 and FBrf0219823).
Protein Function (UniProtKB)
Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role in restoring dopamine homeostasis.
(UniProt, P41596)
Summary (Interactive Fly)

GPCR - mediates aversive and appetitive learning in pavlovian olfactory conditioning - potentiates hindleg grooming behavior in Drosophila

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\Dop1R1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P41596)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Double stop-codon suppression (UGA, UGA) postulated; FBrf0216884.

Transposon inserted in intron

Gene model reviewed during 5.44

Gene model reviewed during 6.02

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Dop1R1-RB
FBtr0290283
NM_057659
2661
496
Dop1R1-RC
FBtr0301351
NM_001170136
2616
481
Dop1R1-RD
FBtr0308191
NM_001260163
14565
511
Dop1R1-RE
FBtr0330711
NM_001275634
2661
560
Dop1R1-RF
FBtr0346763
NM_001316525
2661
535
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Dop1R1-PB
FBpp0288722
54.4
496
8.37
NP_477007
AAF55030
Dop1R1-PC
FBpp0290565
52.9
481
8.65
NP_001163607
ACZ94904
Dop1R1-PD
FBpp0300511
56.2
511
8.37
P41596
NP_001247092
AFH06410
Dop1R1-PE
FBpp0303554
60.9
560
7.33
A0A0B4KHI2
NP_001262563
AGB95944
Dop1R1-PF
FBpp0312358
58.4
535
8.04
A0A126GUU2
NP_001303454
ALI30568
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dop1R1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.60

Transcript Expression
Additional Descriptive Data

DopR transcripts appear to be maternally inherited and are abundant in syncytial stages. At these and cellular stages, transcripts are restricted to apical regions of the cortical, peripheral cytoplasm. Later, DopR transcripts are specifically associated with the extending germ band and are excluded from the invaginating posterior mesoderm and the presumptive head regions. DopR transcripts are uniformly distributed in all developing tissues in later stages of embryogenesis.

(Sugamori et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
apterous-expressing neuron of the lateral cluster of the thorax Ap1
(Baumgardt et al., 2007)
adult stage
adult ellipsoid body ring neuron R4d | restricted
(Kahsai et al., 2012)
adult ellipsoid body ring neuron R3 | restricted
(Kahsai et al., 2012)
ellipsoid body outer central domain | restricted
(Kahsai et al., 2012)
fan-shaped body | restricted
(Kahsai et al., 2012)
nodulus
(Kahsai et al., 2012, Kong et al., 2010)
ellipsoid body
(Kong et al., 2010)
fan-shaped body
(Kong et al., 2010)
adult mushroom body
(Kong et al., 2010)
pedunculus of adult mushroom body
(Kong et al., 2010)
adult ventral nerve cord | restricted
(Pitmon et al., 2016)
adult fat body

Comment: assayed in females

(Gruntenko et al., 2012)
adult corpus allatum

Comment: assayed in females

(Gruntenko et al., 2012)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Expression of Dop1R1 protein is more pronounced in the corpus allatum of newly eclosed female flies than in sexually mature (6 days old) flies; while the opposite is observed in the fat bodies of newly eclosed vs. mature female flies, where higher levels are observed in older flies.

(Gruntenko et al., 2012)

DopR protein is detected in the ellipsoid body, in the rings innervated by R3 and R4d ring neurons. In the fan-shaped body, strong expression is observed in the dorsal and ventral layers, with weaker labelling observed in the central layers. In the nodulus, strong expression is observed in layers I and II.

(Kahsai et al., 2012)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GMR72B02-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult mushroom body
(Jiang et al., 2016)
adult optic lobe
(Jiang et al., 2016)
Reporter: P{GMR72B03-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult pars intercerebralis
(Jiang et al., 2016)
adult median bundle
(Jiang et al., 2016)
adult antennal lobe
(Jiang et al., 2016)
antler
(Jiang et al., 2016)
prow
(Jiang et al., 2016)
Reporter: P{GMR72B08-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
gamma Kenyon cell
(Yamazaki et al., 2018)
adult mushroom body
(Jiang et al., 2016)
adult optic lobe
(Jiang et al., 2016)
Reporter: P{GMR72B09-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
ellipsoid body
(Jiang et al., 2016)
adult lateral horn
(Jiang et al., 2016)
adult gnathal ganglion
(Jiang et al., 2016)
adult mushroom body
(Jiang et al., 2016)
Reporter: P{GMR72B10-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
wedge | faint | restricted
(Jenett and Svirskas, 2012.9.24)
antennal mechanosensory and motor center
(Jiang et al., 2016)
adult lateral horn
(Jiang et al., 2016)
protocerebral bridge
(Jiang et al., 2016)
adult gnathal ganglion
(Jiang et al., 2016)
Reporter: P{GMR72B12-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult mushroom body | intense | restricted
(Jenett and Svirskas, 2012.9.24)
posterior lateral protocerebrum | faint | restricted
(Jenett and Svirskas, 2012.9.24)
adult mushroom body
(Jiang et al., 2016)
adult antennal lobe
(Jiang et al., 2016)
fan-shaped body
(Jiang et al., 2016)
nodulus
(Jiang et al., 2016)
Reporter: P{GMR72C01-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
anterior optic tubercle | faint | restricted
(Jenett and Svirskas, 2012.9.24)
antennal mechanosensory and motor center | intense | restricted
(Jenett and Svirskas, 2012.9.24)
adult mushroom body
(Jiang et al., 2016)
antennal mechanosensory and motor center
(Jiang et al., 2016)
protocerebral bridge
(Jiang et al., 2016)
adult gnathal ganglion
(Jiang et al., 2016)
adult optic lobe
(Jiang et al., 2016)
fan-shaped body
(Jiang et al., 2016)
Reporter: P{GMR72C02-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
gall | faint | restricted
(Jenett and Svirskas, 2012.9.24)
adult mushroom body | intense | restricted
(Jenett and Svirskas, 2012.9.24)
adult mushroom body
(Jiang et al., 2016)
adult antennal lobe
(Jiang et al., 2016)
adult lateral horn
(Jiang et al., 2016)
adult optic lobe
(Jiang et al., 2016)
Reporter: PBac{GAL4D,EYFP}Dop1R1PL00420
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
ellipsoid body
(Bai and Sehgal, 2015, Kong et al., 2010)
adult central complex
(Kong et al., 2010)
nodulus
(Kong et al., 2010)
fan-shaped body
(Bai and Sehgal, 2015, Kong et al., 2010)
adult mushroom body
(Kong et al., 2010)
pedunculus of adult mushroom body
(Kong et al., 2010)
adult antennal lobe glomerulus | subset
(Kong et al., 2010)
adult protocerebrum | restricted
(Kong et al., 2010)
adult ellipsoid body R-neuron
(Kong et al., 2010)
adult mushroom body | faint
(Bai and Sehgal, 2015)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Dop1R1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 22 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Dop1R1
Transgenic constructs containing regulatory region of Dop1R1
Aberrations (Deficiencies and Duplications) ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4elav.PLu
lethal | pupal stage, with Scer\GAL4pnr-MD237
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
viable
viable, with Scer\GAL4Mef2.PR
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal chemosensory behavior | dominant | larval stage
abnormal chemosensory behavior | larval stage, with Scer\GAL4NPF.1
abnormal courtship behavior | male
abnormal courtship behavior | male, with Scer\GAL41471
abnormal courtship behavior | male, with Scer\GAL4Tab2-201Y
abnormal feeding behavior | dominant | larval stage
abnormal feeding behavior | larval stage, with Scer\GAL4NPF.1
abnormal flight, with Scer\GAL4elav.PLu
abnormal flight, with Scer\GAL4Mef2.PR
abnormal learning
abnormal learning, with Scer\GAL4c747
abnormal learning (with In(3LR)234)
abnormal learning | male
abnormal learning | male, with Scer\GAL41471
abnormal learning | male, with Scer\GAL4Tab2-201Y
abnormal learning | recessive
abnormal locomotor behavior | adult stage, with Scer\GAL4Clk.-856
abnormal locomotor behavior | RU486 conditional, with Scer\GAL4Pdf.Switch1a
abnormal memory
abnormal memory, with Dop1R1f02676, Scer\GAL4ey-OK107
abnormal memory, with Dop1R1UAS.cKa, Scer\GAL4ey-OK107
abnormal memory | adult stage
abnormal memory | adult stage, with Hsap\RELAAD.R13F02, Scer\GAL4DBD.R44E04
abnormal memory | adult stage, with Scer\GAL4c739
abnormal memory | adult stage, with Scer\GAL4nSyb.PS
abnormal neurophysiology
abnormal sleep | adult stage
abnormal smell perception
abnormal thermotaxis | adult stage
abnormal thermotaxis | adult stage (with Df(3R)red-P52)
decreased rate of movement | adult stage
decreased rate of movement | chemical conditional
decreased rate of movement | chemical conditional (with Df(3R)ED5634)
decreased sleep, with Scer\GAL4Pdf.PU
decreased sleep | RU486 conditional, with Scer\GAL4Pdf.Switch1a
increased rate of movement | chemical conditional
some die during immature adult stage | recessive, with Scer\GAL4elav.PLu
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (183)
Hsap\DRD1
10 of 14
Yes
Yes
2  
Hsap\DRD5
9 of 14
No
Yes
Hsap\HTR4
2 of 14
No
No
Hsap\HTR6
2 of 14
No
Yes
Hsap\ADORA1
1 of 14
No
No
Hsap\ADORA2A
1 of 14
No
No
2  
Hsap\ADORA2B
1 of 14
No
No
1  
Hsap\ADORA3
1 of 14
No
No
Hsap\ADRA1A
1 of 14
No
No
Hsap\ADRA1B
1 of 14
No
No
Hsap\ADRA1D
1 of 14
No
No
Hsap\ADRA2A
1 of 14
No
No
Hsap\ADRA2B
1 of 14
No
No
Hsap\ADRA2C
1 of 14
No
No
Hsap\ADRB1
1 of 14
No
No
Hsap\ADRB2
1 of 14
No
No
2  
Hsap\ADRB3
1 of 14
No
No
Hsap\AGTR1
1 of 14
No
No
Hsap\APLNR
1 of 14
No
No
Hsap\AVPR1A
1 of 14
No
Yes
1  
Hsap\AVPR1B
1 of 14
No
Yes
Hsap\BRS3
1 of 14
No
No
Hsap\CCKAR
1 of 14
No
No
Hsap\CCKBR
1 of 14
No
No
1  
Hsap\CCR2
1 of 14
No
Yes
Hsap\CCRL2
1 of 14
No
Yes
Hsap\CHRM1
1 of 14
No
No
1  
Hsap\CHRM2
1 of 14
No
No
Hsap\CHRM3
1 of 14
No
No
5  
Hsap\CHRM4
1 of 14
No
No
1  
Hsap\CHRM5
1 of 14
No
No
Hsap\CNR1
1 of 14
No
Yes
1  
Hsap\CNR2
1 of 14
No
Yes
Hsap\CXCR1
1 of 14
No
Yes
Hsap\CXCR4
1 of 14
No
Yes
Hsap\DRD2
1 of 14
No
No
8  
Hsap\DRD3
1 of 14
No
No
Hsap\DRD4
1 of 14
No
No
Hsap\EDNRA
1 of 14
No
Yes
Hsap\EDNRB
1 of 14
No
Yes
Hsap\GALR1
1 of 14
No
No
Hsap\GALR2
1 of 14
No
No
Hsap\GALR3
1 of 14
No
No
Hsap\GHSR
1 of 14
No
No
Hsap\GPER1
1 of 14
No
Yes
Hsap\GPR3
1 of 14
No
Yes
Hsap\GPR4
1 of 14
No
Yes
Hsap\GPR6
1 of 14
No
Yes
Hsap\GPR12
1 of 14
No
Yes
Hsap\GPR17
1 of 14
No
No
Hsap\GPR21
1 of 14
No
No
Hsap\GPR26
1 of 14
No
Yes
Hsap\GPR27
1 of 14
No
Yes
Hsap\GPR39
1 of 14
No
No
1  
Hsap\GPR45
1 of 14
No
Yes
Hsap\GPR50
1 of 14
No
No
Hsap\GPR52
1 of 14
No
No
Hsap\GPR61
1 of 14
No
Yes
Hsap\GPR62
1 of 14
No
Yes
Hsap\GPR63
1 of 14
No
Yes
Hsap\GPR78
1 of 14
No
Yes
Hsap\GPR83
1 of 14
No
No
Hsap\GPR84
1 of 14
No
No
1  
Hsap\GPR85
1 of 14
No
Yes
Hsap\GPR101
1 of 14
No
No
Hsap\GPR119
1 of 14
No
Yes
Hsap\GPR139
1 of 14
No
No
Hsap\GPR142
1 of 14
No
No
Hsap\GPR148
1 of 14
No
No
Hsap\GPR161
1 of 14
No
Yes
Hsap\GPR173
1 of 14
No
Yes
Hsap\GPR176
1 of 14
No
Yes
Hsap\HCRTR1
1 of 14
No
No
Hsap\HCRTR2
1 of 14
No
No
Hsap\HRH1
1 of 14
No
No
Hsap\HRH2
1 of 14
No
No
2  
Hsap\HRH3
1 of 14
No
No
Hsap\HRH4
1 of 14
No
No
Hsap\HTR1A
1 of 14
No
No
Hsap\HTR1B
1 of 14
No
No
1  
Hsap\HTR1D
1 of 14
No
No
3  
Hsap\HTR1E
1 of 14
No
No
Hsap\HTR1F
1 of 14
No
No
Hsap\HTR2A
1 of 14
No
No
Hsap\HTR2B
1 of 14
No
No
Hsap\HTR2C
1 of 14
No
No
2  
Hsap\HTR5A
1 of 14
No
No
Hsap\HTR7
1 of 14
No
No
1  
Hsap\KISS1R
1 of 14
No
No
Hsap\LPAR1
1 of 14
No
Yes
Hsap\LPAR2
1 of 14
No
Yes
Hsap\LPAR3
1 of 14
No
Yes
Hsap\LPAR6
1 of 14
No
No
Hsap\MC1R
1 of 14
No
Yes
Hsap\MC2R
1 of 14
No
Yes
Hsap\MC3R
1 of 14
No
Yes
Hsap\MC4R
1 of 14
No
Yes
Hsap\MC5R
1 of 14
No
Yes
Hsap\MCHR1
1 of 14
No
No
Hsap\MLNR
1 of 14
No
No
Hsap\MTNR1A
1 of 14
No
No
Hsap\MTNR1B
1 of 14
No
No
Hsap\NMBR
1 of 14
No
No
Hsap\NMUR1
1 of 14
No
No
Hsap\NMUR2
1 of 14
No
No
2  
Hsap\NPBWR2
1 of 14
No
No
Hsap\NPFFR1
1 of 14
No
No
Hsap\NPFFR2
1 of 14
No
No
2  
Hsap\NPY1R
1 of 14
No
No
Hsap\NPY2R
1 of 14
No
No
Hsap\NPY5R
1 of 14
No
No
Hsap\NTSR1
1 of 14
No
No
Hsap\NTSR2
1 of 14
No
No
Hsap\OPN1LW
1 of 14
No
No
Hsap\OPN1MW2
1 of 14
No
No
Hsap\OPN1MW3
1 of 14
No
No
Hsap\OPN1MW
1 of 14
No
No
Hsap\OPN1SW
1 of 14
No
No
Hsap\OPN3
1 of 14
No
No
Hsap\OPN4
1 of 14
No
No
1  
Hsap\OPN5
1 of 14
No
No
Hsap\OPRD1
1 of 14
No
No
Hsap\OPRK1
1 of 14
No
No
Hsap\OPRL1
1 of 14
No
No
1  
Hsap\OPRM1
1 of 14
No
No
1  
Hsap\OR2A14
1 of 14
No
Yes
Hsap\OR2D2
1 of 14
No
Yes
Hsap\OR2V2
1 of 14
No
Yes
Hsap\OR4D2
1 of 14
No
Yes
Hsap\OR4K5
1 of 14
No
Yes
Hsap\OR4L1
1 of 14
No
Yes
Hsap\OR5T2
1 of 14
No
Yes
Hsap\OR5T3
1 of 14
No
Yes
Hsap\OR6T1
1 of 14
No
Yes
Hsap\OR10A7
1 of 14
No
Yes
Hsap\OR10H1
1 of 14
No
Yes
Hsap\OR10H2
1 of 14
No
Yes
Hsap\OR10H3
1 of 14
No
Yes
Hsap\OR10H4
1 of 14
No
Yes
Hsap\OR10H5
1 of 14
No
Yes
Hsap\OR10J5
1 of 14
No
Yes
Hsap\OR10J6P
1 of 14
No
Yes
Hsap\OR11H4
1 of 14
No
Yes
Hsap\OR11H7
1 of 14
No
Yes
Hsap\OR14I1
1 of 14
No
Yes
Hsap\P2RY1
1 of 14
No
Yes
Hsap\PROKR1
1 of 14
No
Yes
Hsap\PROKR2
1 of 14
No
Yes
Hsap\PTGDR2
1 of 14
No
No
Hsap\PTGDR
1 of 14
No
No
Hsap\PTGER1
1 of 14
No
No
Hsap\PTGER2
1 of 14
No
No
Hsap\PTGER3
1 of 14
No
No
Hsap\PTGER4
1 of 14
No
No
1  
Hsap\PTGFR
1 of 14
No
No
Hsap\PTGIR
1 of 14
No
No
Hsap\QRFPR
1 of 14
No
No
Hsap\RGR
1 of 14
No
No
Hsap\RHO
1 of 14
No
No
Hsap\RRH
1 of 14
No
No
Hsap\RXFP3
1 of 14
No
No
Hsap\S1PR1
1 of 14
No
Yes
Hsap\S1PR2
1 of 14
No
Yes
Hsap\S1PR3
1 of 14
No
Yes
Hsap\S1PR4
1 of 14
No
Yes
Hsap\S1PR5
1 of 14
No
Yes
Hsap\SSTR1
1 of 14
No
No
Hsap\SSTR2
1 of 14
No
No
Hsap\SSTR4
1 of 14
No
No
Hsap\SSTR5
1 of 14
No
No
Hsap\TAAR1
1 of 14
No
No
Hsap\TAAR2
1 of 14
No
No
Hsap\TAAR3P
1 of 14
No
No
Hsap\TAAR5
1 of 14
No
No
Hsap\TAAR6
1 of 14
No
No
Hsap\TAAR8
1 of 14
No
No
Hsap\TAAR9
1 of 14
No
No
Hsap\TACR1
1 of 14
No
No
1  
Hsap\TACR2
1 of 14
No
No
Hsap\TACR3
1 of 14
No
No
Hsap\TBXA2R
1 of 14
No
No
Hsap\TRHR
1 of 14
No
No
Hsap\XCR1
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (107)
Rnor\Drd1
11 of 14
Yes
Yes
Rnor\Drd5
9 of 14
No
Yes
Rnor\Htr6
3 of 14
No
Yes
Rnor\Htr4
2 of 14
No
No
Rnor\Ackr3
1 of 14
No
Yes
Rnor\Adora1
1 of 14
No
No
Rnor\Adora2a
1 of 14
No
No
Rnor\Adora2b
1 of 14
No
No
Rnor\Adora3
1 of 14
No
No
Rnor\Adra1a
1 of 14
No
No
Rnor\Adra1b
1 of 14
No
No
Rnor\Adra1d
1 of 14
No
No
Rnor\Adra2a
1 of 14
No
No
Rnor\Adra2b
1 of 14
No
No
Rnor\Adra2c
1 of 14
No
No
Rnor\Adrb1
1 of 14
No
No
Rnor\Adrb2
1 of 14
No
No
Rnor\Adrb3
1 of 14
No
No
Rnor\Chrm1
1 of 14
No
No
Rnor\Chrm2
1 of 14
No
No
Rnor\Chrm3
1 of 14
No
No
Rnor\Chrm4
1 of 14
No
No
Rnor\Chrm5
1 of 14
No
No
Rnor\Drd2
1 of 14
No
No
Rnor\Drd3
1 of 14
No
No
Rnor\Drd4
1 of 14
No
No
Rnor\Ednrb
1 of 14
No
Yes
Rnor\Gpr12
1 of 14
No
Yes
Rnor\Gpr21
1 of 14
No
No
Rnor\Gpr26
1 of 14
No
Yes
Rnor\Gpr27
1 of 14
No
Yes
Rnor\Gpr45
1 of 14
No
Yes
Rnor\Gpr61
1 of 14
No
Yes
Rnor\Gpr62
1 of 14
No
Yes
Rnor\Gpr63
1 of 14
No
Yes
Rnor\Gpr83
1 of 14
No
No
Rnor\Gpr84
1 of 14
No
No
Rnor\Gpr85
1 of 14
No
Yes
Rnor\Gpr119
1 of 14
No
Yes
Rnor\Gpr161
1 of 14
No
Yes
Rnor\Gpr173
1 of 14
No
Yes
Rnor\Hcrtr1
1 of 14
No
No
Rnor\Hcrtr2
1 of 14
No
No
Rnor\Hrh1
1 of 14
No
No
Rnor\Hrh2
1 of 14
No
No
Rnor\Htr1a
1 of 14
No
No
Rnor\Htr1b
1 of 14
No
No
Rnor\Htr1d
1 of 14
No
No
Rnor\Htr1f
1 of 14
No
No
Rnor\Htr2a
1 of 14
No
No
Rnor\Htr2b
1 of 14
No
No
Rnor\Htr2c
1 of 14
No
No
Rnor\Htr5a
1 of 14
No
No
Rnor\Htr5b
1 of 14
No
No
Rnor\Htr7
1 of 14
No
No
Rnor\Lhcgr
1 of 14
No
No
Rnor\LOC100909683
1 of 14
No
Yes
Rnor\LOC100911796
1 of 14
No
No
Rnor\Lpar1
1 of 14
No
Yes
Rnor\Mc5r
1 of 14
No
Yes
Rnor\Mchr1
1 of 14
No
No
Rnor\Mtnr1b
1 of 14
No
No
Rnor\Npffr1
1 of 14
No
No
Rnor\Npffr2
1 of 14
No
No
Rnor\Olr240
1 of 14
No
Yes
Rnor\Olr241
1 of 14
No
Yes
Rnor\Olr245
1 of 14
No
Yes
Rnor\Olr515
1 of 14
No
Yes
Rnor\Olr517
1 of 14
No
Yes
Rnor\Olr518
1 of 14
No
Yes
Rnor\Olr519
1 of 14
No
Yes
Rnor\Olr1061
1 of 14
No
Yes
Rnor\Olr1090
1 of 14
No
Yes
Rnor\Olr1091
1 of 14
No
Yes
Rnor\Olr1095
1 of 14
No
Yes
Rnor\Olr1413
1 of 14
No
Yes
Rnor\Olr1576
1 of 14
No
Yes
Rnor\Olr1622
1 of 14
No
Yes
Rnor\Olr1631
1 of 14
No
Yes
Rnor\Olr1632
1 of 14
No
Yes
Rnor\Olr1635
1 of 14
No
Yes
Rnor\Olr1875
1 of 14
No
Yes
Rnor\Oprk1
1 of 14
No
No
Rnor\Pgr15l
1 of 14
No
No
Rnor\Ptgdrl
1 of 14
No
No
Rnor\Ptgdr
1 of 14
No
No
Rnor\Ptger1
1 of 14
No
No
Rnor\Ptger2
1 of 14
No
No
Rnor\Ptger3
1 of 14
No
No
Rnor\Ptger4
1 of 14
No
No
Rnor\Ptgfr
1 of 14
No
No
Rnor\Ptgir
1 of 14
No
No
Rnor\S1pr3
1 of 14
No
Yes
Rnor\Sstr4
1 of 14
No
No
Rnor\Taar1
1 of 14
No
No
Rnor\Taar2
1 of 14
No
Yes
Rnor\Taar3
1 of 14
No
Yes
Rnor\Taar4
1 of 14
No
No
Rnor\Taar7a
1 of 14
No
No
Rnor\Taar7b
1 of 14
No
No
Rnor\Taar7d
1 of 14
No
No
Rnor\Taar7h
1 of 14
No
No
Rnor\Taar8c
1 of 14
No
Yes
Rnor\Taar9
1 of 14
No
No
Rnor\Tacr2
1 of 14
No
No
Rnor\Tbxa2r
1 of 14
No
No
Rnor\Trhr
1 of 14
No
No
Mus musculus (laboratory mouse) (111)
Mmus\Drd1
10 of 14
Yes
Yes
Mmus\Drd5
8 of 14
No
Yes
Mmus\Htr4
2 of 14
No
No
Mmus\Htr6
2 of 14
No
Yes
Mmus\Ackr3
1 of 14
No
Yes
Mmus\Adora1
1 of 14
No
No
Mmus\Adora2a
1 of 14
No
No
Mmus\Adora2b
1 of 14
No
No
Mmus\Adora3
1 of 14
No
No
Mmus\Adra1a
1 of 14
No
No
Mmus\Adra1b
1 of 14
No
No
Mmus\Adra1d
1 of 14
No
No
Mmus\Adra2a
1 of 14
No
No
Mmus\Adra2b
1 of 14
No
No
Mmus\Adra2c
1 of 14
No
No
Mmus\Adrb1
1 of 14
No
No
Mmus\Adrb2
1 of 14
No
No
Mmus\Adrb3
1 of 14
No
No
Mmus\Chrm1
1 of 14
No
No
Mmus\Chrm2
1 of 14
No
No
Mmus\Chrm3
1 of 14
No
No
Mmus\Chrm4
1 of 14
No
No
Mmus\Chrm5
1 of 14
No
No
Mmus\Drd2
1 of 14
No
No
Mmus\Drd3
1 of 14
No
No
Mmus\Drd4
1 of 14
No
Yes
Mmus\Galr2
1 of 14
No
No
Mmus\Gpr21
1 of 14
No
No
Mmus\Gpr26
1 of 14
No
Yes
Mmus\Gpr27
1 of 14
No
Yes
Mmus\Gpr45
1 of 14
No
Yes
Mmus\Gpr50
1 of 14
No
No
Mmus\Gpr52
1 of 14
No
No
Mmus\Gpr61
1 of 14
No
Yes
Mmus\Gpr62
1 of 14
No
Yes
Mmus\Gpr63
1 of 14
No
Yes
Mmus\Gpr83
1 of 14
No
No
Mmus\Gpr84
1 of 14
No
No
Mmus\Gpr85
1 of 14
No
Yes
Mmus\Gpr119
1 of 14
No
Yes
Mmus\Gpr161
1 of 14
No
Yes
Mmus\Gpr173
1 of 14
No
Yes
Mmus\Hcrtr2
1 of 14
No
No
Mmus\Hrh1
1 of 14
No
No
Mmus\Hrh2
1 of 14
No
No
Mmus\Hrh4
1 of 14
No
No
Mmus\Htr1a
1 of 14
No
No
Mmus\Htr1b
1 of 14
No
No
Mmus\Htr1d
1 of 14
No
No
Mmus\Htr1f
1 of 14
No
No
Mmus\Htr2a
1 of 14
No
No
Mmus\Htr2b
1 of 14
No
No
Mmus\Htr2c
1 of 14
No
No
Mmus\Htr5a
1 of 14
No
No
Mmus\Htr5b
1 of 14
No
No
Mmus\Htr7
1 of 14
No
No
Mmus\Kiss1r
1 of 14
No
No
Mmus\Lpar1
1 of 14
No
Yes
Mmus\Mc5r
1 of 14
No
Yes
Mmus\Mchr1
1 of 14
No
No
Mmus\Mtnr1a
1 of 14
No
No
Mmus\Mtnr1b
1 of 14
No
No
Mmus\Npffr1
1 of 14
No
No
Mmus\Npffr2
1 of 14
No
No
Mmus\Npy6r
1 of 14
No
No
Mmus\Olfr16
1 of 14
No
Yes
Mmus\Olfr30
1 of 14
No
Yes
Mmus\Olfr53
1 of 14
No
Yes
Mmus\Olfr55
1 of 14
No
Yes
Mmus\Olfr61
1 of 14
No
Yes
Mmus\Olfr63
1 of 14
No
Yes
Mmus\Olfr239
1 of 14
No
Yes
Mmus\Olfr472
1 of 14
No
Yes
Mmus\Olfr473
1 of 14
No
Yes
Mmus\Olfr474
1 of 14
No
Yes
Mmus\Olfr479
1 of 14
No
Yes
Mmus\Olfr509
1 of 14
No
Yes
Mmus\Olfr746
1 of 14
No
Yes
Mmus\Olfr747
1 of 14
No
Yes
Mmus\Olfr748
1 of 14
No
Yes
Mmus\Olfr749
1 of 14
No
Yes
Mmus\Olfr1093
1 of 14
No
Yes
Mmus\Olfr1094
1 of 14
No
Yes
Mmus\Olfr1102
1 of 14
No
Yes
Mmus\Olfr1396
1 of 14
No
Yes
Mmus\Olfr1564
1 of 14
No
Yes
Mmus\Oprk1
1 of 14
No
No
Mmus\Pgr15l
1 of 14
No
No
Mmus\Ptgdr
1 of 14
No
No
Mmus\Ptger1
1 of 14
No
No
Mmus\Ptger2
1 of 14
No
No
Mmus\Ptger3
1 of 14
No
No
Mmus\Ptger4
1 of 14
No
No
Mmus\Ptgfr
1 of 14
No
No
Mmus\Ptgir
1 of 14
No
No
Mmus\S1pr3
1 of 14
No
Yes
Mmus\S1pr4
1 of 14
No
Yes
Mmus\Sstr4
1 of 14
No
No
Mmus\Taar1
1 of 14
No
No
Mmus\Taar2
1 of 14
No
Yes
Mmus\Taar3
1 of 14
No
Yes
Mmus\Taar4
1 of 14
No
No
Mmus\Taar7a
1 of 14
No
No
Mmus\Taar7b
1 of 14
No
No
Mmus\Taar7d
1 of 14
No
No
Mmus\Taar7e
1 of 14
No
No
Mmus\Taar7f
1 of 14
No
No
Mmus\Taar9
1 of 14
No
No
Mmus\Tacr2
1 of 14
No
No
Mmus\Tbxa2r
1 of 14
No
No
Mmus\Trhr
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (130)
Xtro\drd1c
9 of 13
Yes
Yes
Xtro\drd1
8 of 13
No
Yes
Xtro\drd5
6 of 13
No
Yes
Xtro\ackr4
1 of 13
No
Yes
Xtro\adora1
1 of 13
No
No
Xtro\adora2a
1 of 13
No
No
Xtro\adora2b
1 of 13
No
No
Xtro\adora3.1
1 of 13
No
No
Xtro\adora3.2
1 of 13
No
No
Xtro\adra1a
1 of 13
No
No
Xtro\adra1d
1 of 13
No
No
Xtro\adra2b
1 of 13
No
No
Xtro\adra2c
1 of 13
No
No
Xtro\adrb2
1 of 13
No
No
Xtro\agtr1
1 of 13
No
No
Xtro\agtr2
1 of 13
No
No
Xtro\aplnr
1 of 13
No
No
Xtro\avpr1a
1 of 13
No
No
Xtro\avpr2.2
1 of 13
No
Yes
Xtro\avpr2
1 of 13
No
Yes
Xtro\bdkrb2
1 of 13
No
No
Xtro\brs3
1 of 13
No
No
Xtro\calhm4
1 of 13
No
Yes
Xtro\cbwd1.1
1 of 13
No
No
Xtro\ccr3
1 of 13
No
Yes
Xtro\chrm1
1 of 13
No
No
Xtro\chrm2
1 of 13
No
No
Xtro\chrm3
1 of 13
No
No
Xtro\chrm5
1 of 13
No
No
Xtro\cnr2
1 of 13
No
Yes
Xtro\crybb3
1 of 13
No
No
Xtro\drd4
1 of 13
No
No
Xtro\ednrb
1 of 13
No
Yes
Xtro\galr1
1 of 13
No
No
Xtro\galr2
1 of 13
No
No
Xtro\galr3
1 of 13
No
No
Xtro\ghsr
1 of 13
No
No
Xtro\gnrhr2/nmi
1 of 13
No
No
Xtro\gnrhr2
1 of 13
No
No
Xtro\gpr6
1 of 13
No
Yes
Xtro\gpr12
1 of 13
No
Yes
Xtro\gpr27
1 of 13
No
Yes
Xtro\gpr65
1 of 13
No
Yes
Xtro\gpr78
1 of 13
No
Yes
Xtro\gpr83
1 of 13
No
No
Xtro\gpr85
1 of 13
No
Yes
Xtro\gpr119
1 of 13
No
Yes
Xtro\gpr142
1 of 13
No
No
Xtro\gpr148
1 of 13
No
No
Xtro\gpr161
1 of 13
No
Yes
Xtro\gpr173
1 of 13
No
Yes
Xtro\gpr174
1 of 13
No
Yes
Xtro\gpr176
1 of 13
No
Yes
Xtro\hrh4.b2
1 of 13
No
No
Xtro\hrh4.d1
1 of 13
No
Yes
Xtro\htr1b
1 of 13
No
No
Xtro\htr1e
1 of 13
No
No
Xtro\htr2c
1 of 13
No
No
Xtro\htr5a
1 of 13
No
No
Xtro\htr7
1 of 13
No
No
Xtro\kiss1r
1 of 13
No
No
Xtro\kissr1b
1 of 13
No
No
Xtro\kissr2
1 of 13
No
No
Xtro\LOC100488258
1 of 13
No
No
Xtro\LOC100489056
1 of 13
No
No
Xtro\LOC100489151
1 of 13
No
Yes
Xtro\LOC100489992
1 of 13
No
No
Xtro\LOC100490372
1 of 13
No
No
Xtro\LOC100491797
1 of 13
No
No
Xtro\LOC100495677
1 of 13
No
Yes
Xtro\LOC100496229
1 of 13
No
Yes
Xtro\LOC100498398
1 of 13
No
Yes
Xtro\LOC101733830
1 of 13
No
Yes
Xtro\LOC101734771
1 of 13
No
No
Xtro\LOC105946838
1 of 13
No
No
Xtro\LOC116407926
1 of 13
No
Yes
Xtro\LOC116411706
1 of 13
No
Yes
Xtro\lpar1
1 of 13
No
Yes
Xtro\lpar3
1 of 13
No
Yes
Xtro\mc2r
1 of 13
No
Yes
Xtro\mc4r
1 of 13
No
Yes
Xtro\mc5r
1 of 13
No
Yes
Xtro\mchr1.1
1 of 13
No
No
Xtro\mchr1.2
1 of 13
No
No
Xtro\mchr2
1 of 13
No
No
Xtro\mlnr
1 of 13
No
No
Xtro\mtnr1c
1 of 13
No
No
Xtro\nmbr
1 of 13
No
No
Xtro\nmur2
1 of 13
No
No
Xtro\npsr1
1 of 13
No
No
Xtro\npy1r
1 of 13
No
No
Xtro\npy2rl
1 of 13
No
No
Xtro\npy2r
1 of 13
No
No
Xtro\npy4r
1 of 13
No
No
Xtro\npy5r
1 of 13
No
No
Xtro\ntsr2
1 of 13
No
No
Xtro\opn1lw
1 of 13
No
No
Xtro\opn1sw
1 of 13
No
No
Xtro\opn3
1 of 13
No
Yes
Xtro\opn5
1 of 13
No
No
Xtro\opn8
1 of 13
No
No
Xtro\opnpl [provisonal]
1 of 13
No
No
Xtro\p2ry4
1 of 13
No
Yes
Xtro\prlhr
1 of 13
No
No
Xtro\ptgdr
1 of 13
No
No
Xtro\ptger3
1 of 13
No
No
Xtro\ptgfr
1 of 13
No
No
Xtro\ptgir
1 of 13
No
No
Xtro\qrfprl2.2
1 of 13
No
Yes
Xtro\qrfpr
1 of 13
No
Yes
Xtro\rho
1 of 13
No
Yes
Xtro\rrh
1 of 13
No
No
Xtro\s1pr1
1 of 13
No
Yes
Xtro\s1pr5
1 of 13
No
Yes
Xtro\sstr2
1 of 13
No
No
Xtro\taar1
1 of 13
No
No
Xtro\taar3p
1 of 13
No
No
Xtro\tacr1
1 of 13
No
No
Xtro\tacr3
1 of 13
No
No
Xtro\tbxa2r
1 of 13
No
No
Xtro\tmtops2
1 of 13
No
No
Xtro\tmtops.2
1 of 13
No
Yes
Xtro\tmtops
1 of 13
No
Yes
Xtro\trhr2
1 of 13
No
No
Xtro\trhr
1 of 13
No
No
Xtro\uts2rl
1 of 13
No
No
Xtro\XB982628
1 of 13
No
No
Xtro\XB994602
1 of 13
No
No
Xtro\XB996286
1 of 13
No
No
Xtro\XB5959819
1 of 13
No
Yes
Danio rerio (Zebrafish) (160)
Drer\drd6b
11 of 14
Yes
Yes
Drer\drd1b
10 of 14
No
Yes
Drer\LOC567498
10 of 14
No
Yes
Drer\drd7
9 of 14
No
Yes
Drer\LOC563567
9 of 14
No
Yes
Drer\drd1a
8 of 14
No
Yes
Drer\htr4
2 of 14
No
No
Drer\htr6
2 of 14
No
Yes
Drer\si:dkey-247m21.3
2 of 14
No
No
Drer\taar10
2 of 14
No
Yes
Drer\taar12m
2 of 14
No
Yes
Drer\adora1b
1 of 14
No
No
Drer\adora2aa
1 of 14
No
No
Drer\adora2b
1 of 14
No
No
Drer\adora4a
1 of 14
No
No
Drer\adra1aa
1 of 14
No
No
Drer\adra1ab
1 of 14
No
No
Drer\adra1ba
1 of 14
No
No
Drer\adra1bb
1 of 14
No
No
Drer\adra1d
1 of 14
No
No
Drer\adra2a
1 of 14
No
No
Drer\adra2b
1 of 14
No
No
Drer\adra2c
1 of 14
No
No
Drer\adra2da
1 of 14
No
No
Drer\adra2db
1 of 14
No
No
Drer\adrb1
1 of 14
No
No
Drer\adrb2a
1 of 14
No
No
Drer\adrb2b
1 of 14
No
No
Drer\adrb3a
1 of 14
No
No
Drer\adrb3b
1 of 14
No
No
Drer\avpr1ab
1 of 14
No
No
Drer\avpr2aa
1 of 14
No
No
Drer\cckar
1 of 14
No
No
Drer\cckbra
1 of 14
No
No
Drer\chrm1a
1 of 14
No
No
Drer\chrm2a
1 of 14
No
No
Drer\chrm2b
1 of 14
No
No
Drer\chrm3a
1 of 14
No
No
Drer\chrm3b
1 of 14
No
No
Drer\chrm4a
1 of 14
No
No
Drer\chrm4b
1 of 14
No
No
Drer\chrm5a
1 of 14
No
No
Drer\chrm5b
1 of 14
No
No
Drer\cmklr2
1 of 14
No
No
Drer\drd2a
1 of 14
No
No
Drer\drd2b
1 of 14
No
No
Drer\drd2l
1 of 14
No
No
Drer\drd3
1 of 14
No
No
Drer\drd4a
1 of 14
No
No
Drer\drd4b
1 of 14
No
No
Drer\drd4-rs
1 of 14
No
No
Drer\drd5a
1 of 14
No
Yes
Drer\galr1b
1 of 14
No
No
Drer\galr2a
1 of 14
No
No
Drer\galr2b
1 of 14
No
No
Drer\gpr6
1 of 14
No
Yes
Drer\gpr26
1 of 14
No
Yes
Drer\gpr27
1 of 14
No
Yes
Drer\gpr45
1 of 14
No
Yes
Drer\gpr52
1 of 14
No
No
Drer\gpr61
1 of 14
No
Yes
Drer\gpr61l
1 of 14
No
Yes
Drer\gpr63
1 of 14
No
Yes
Drer\gpr78a
1 of 14
No
Yes
Drer\gpr78b
1 of 14
No
Yes
Drer\gpr84
1 of 14
No
No
Drer\gpr85
1 of 14
No
Yes
Drer\gpr161b
1 of 14
No
Yes
Drer\gpr173
1 of 14
No
Yes
Drer\gpr176
1 of 14
No
Yes
Drer\hcrtr2
1 of 14
No
No
Drer\hrh2a
1 of 14
No
No
Drer\hrh2b
1 of 14
No
No
Drer\hrh3
1 of 14
No
Yes
Drer\htr1aa
1 of 14
No
No
Drer\htr1ab
1 of 14
No
No
Drer\htr1b
1 of 14
No
No
Drer\htr1d
1 of 14
No
No
Drer\htr1fa
1 of 14
No
No
Drer\htr1fb
1 of 14
No
No
Drer\htr2aa
1 of 14
No
No
Drer\htr2ab
1 of 14
No
No
Drer\htr2b
1 of 14
No
No
Drer\htr2cl1
1 of 14
No
No
Drer\htr2cl2
1 of 14
No
No
Drer\htr5aa
1 of 14
No
No
Drer\htr5ab
1 of 14
No
No
Drer\htr7a
1 of 14
No
No
Drer\htr7c
1 of 14
No
No
Drer\htr7
1 of 14
No
No
Drer\LOC561565
1 of 14
No
No
Drer\LOC571410
1 of 14
No
No
Drer\LOC100001479
1 of 14
No
Yes
Drer\LOC100007535
1 of 14
No
No
Drer\LOC100330650
1 of 14
No
No
Drer\LOC100331077
1 of 14
No
Yes
Drer\LOC100331465
1 of 14
No
No
Drer\LOC100331807
1 of 14
No
No
Drer\LOC100334962
1 of 14
No
No
Drer\LOC101884544
1 of 14
No
No
Drer\LOC101886918
1 of 14
No
Yes
Drer\LOC108179103
1 of 14
No
No
Drer\LOC110437881
1 of 14
No
No
Drer\mc1r
1 of 14
No
Yes
Drer\mc3r
1 of 14
No
Yes
Drer\mc4r
1 of 14
No
Yes
Drer\mchr1b
1 of 14
No
No
Drer\npffr1
1 of 14
No
No
Drer\npffr1l1
1 of 14
No
No
Drer\opn3
1 of 14
No
Yes
Drer\opn4xa
1 of 14
No
No
Drer\opn4xb
1 of 14
No
No
Drer\oprd1a
1 of 14
No
No
Drer\parietopsin
1 of 14
No
Yes
Drer\ptger1a
1 of 14
No
No
Drer\ptger1b
1 of 14
No
No
Drer\ptger1c
1 of 14
No
No
Drer\ptger2a
1 of 14
No
No
Drer\ptger2b
1 of 14
No
No
Drer\ptger3
1 of 14
No
No
Drer\ptger4a
1 of 14
No
No
Drer\ptger4b
1 of 14
No
No
Drer\ptger4c
1 of 14
No
No
Drer\ptgfr
1 of 14
No
No
Drer\ptgir
1 of 14
No
No
Drer\rho
1 of 14
No
No
Drer\s1pr3a
1 of 14
No
Yes
Drer\si:ch73-160i9.3
1 of 14
No
Yes
Drer\si:ch211-213o11.11
1 of 14
No
Yes
Drer\sstr2a
1 of 14
No
No
Drer\sstr3
1 of 14
No
No
Drer\taar1b
1 of 14
No
No
Drer\taar10a
1 of 14
No
No
Drer\taar10b
1 of 14
No
Yes
Drer\taar10c
1 of 14
No
No
Drer\taar10d
1 of 14
No
No
Drer\taar12a
1 of 14
No
No
Drer\taar12e
1 of 14
No
Yes
Drer\taar12f
1 of 14
No
Yes
Drer\taar12g
1 of 14
No
Yes
Drer\taar12h
1 of 14
No
Yes
Drer\taar12j
1 of 14
No
No
Drer\taar13a
1 of 14
No
No
Drer\taar13b
1 of 14
No
No
Drer\taar13c
1 of 14
No
Yes
Drer\taar13d
1 of 14
No
No
Drer\taar13e
1 of 14
No
No
Drer\taar14h
1 of 14
No
No
Drer\taar14i
1 of 14
No
Yes
Drer\taar19g
1 of 14
No
No
Drer\taar19s
1 of 14
No
No
Drer\taar20b1
1 of 14
No
No
Drer\taar20c
1 of 14
No
No
Drer\taar20j
1 of 14
No
No
Drer\tacr1a
1 of 14
No
No
Drer\tacr1b
1 of 14
No
No
Drer\tacr3l
1 of 14
No
No
Drer\tbxa2r
1 of 14
No
No
Drer\trhr2
1 of 14
No
No
Drer\trhra
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (80)
Cele\dop-1
9 of 14
Yes
Yes
Cele\ador-1
1 of 14
No
No
Cele\AH9.1
1 of 14
No
No
Cele\B0334.6
1 of 14
No
No
Cele\B0563.6
1 of 14
No
No
Cele\C17H11.1
1 of 14
No
No
Cele\C24A8.6
1 of 14
No
Yes
Cele\ckr-1
1 of 14
No
No
Cele\ckr-2
1 of 14
No
No
Cele\D1014.2
1 of 14
No
Yes
Cele\dmsr-2
1 of 14
No
No
Cele\dmsr-6
1 of 14
No
No
Cele\dmsr-7
1 of 14
No
No
Cele\dmsr-8
1 of 14
No
No
Cele\dmsr-9
1 of 14
No
No
Cele\dop-2
1 of 14
No
No
Cele\dop-3
1 of 14
No
No
Cele\dop-4
1 of 14
No
No
Cele\dop-5
1 of 14
No
Yes
Cele\dop-6
1 of 14
No
No
Cele\F59B2.13
1 of 14
No
Yes
Cele\frpr-2
1 of 14
No
No
Cele\frpr-3
1 of 14
No
No
Cele\frpr-5
1 of 14
No
No
Cele\frpr-6
1 of 14
No
No
Cele\frpr-7
1 of 14
No
No
Cele\frpr-8
1 of 14
No
No
Cele\frpr-9
1 of 14
No
No
Cele\frpr-10
1 of 14
No
No
Cele\frpr-11
1 of 14
No
No
Cele\frpr-12
1 of 14
No
No
Cele\frpr-14
1 of 14
No
No
Cele\frpr-15
1 of 14
No
No
Cele\frpr-16
1 of 14
No
No
Cele\frpr-18
1 of 14
No
No
Cele\frpr-19
1 of 14
No
No
Cele\gar-1
1 of 14
No
No
Cele\gar-2
1 of 14
No
No
Cele\gar-3
1 of 14
No
No
Cele\K03H6.1
1 of 14
No
Yes
Cele\K03H6.5
1 of 14
No
Yes
Cele\nmur-1
1 of 14
No
No
Cele\nmur-2
1 of 14
No
No
Cele\nmur-3
1 of 14
No
No
Cele\npr-1
1 of 14
No
No
Cele\npr-2
1 of 14
No
No
Cele\npr-3
1 of 14
No
No
Cele\npr-4
1 of 14
No
No
Cele\npr-5
1 of 14
No
No
Cele\npr-6
1 of 14
No
No
Cele\npr-9
1 of 14
No
No
Cele\npr-15
1 of 14
No
No
Cele\npr-17
1 of 14
No
No
Cele\npr-20
1 of 14
No
No
Cele\npr-22
1 of 14
No
No
Cele\npr-32
1 of 14
No
No
Cele\npr-33
1 of 14
No
No
Cele\npr-34
1 of 14
No
No
Cele\npr-35
1 of 14
No
No
Cele\ntr-2
1 of 14
No
No
Cele\octr-1
1 of 14
No
No
Cele\R13H7.2
1 of 14
No
Yes
Cele\ser-1
1 of 14
No
No
Cele\ser-2
1 of 14
No
No
Cele\ser-3
1 of 14
No
No
Cele\ser-4
1 of 14
No
No
Cele\ser-5
1 of 14
No
No
Cele\ser-6
1 of 14
No
No
Cele\ser-7
1 of 14
No
No
Cele\sprr-1
1 of 14
No
No
Cele\sprr-2
1 of 14
No
No
Cele\T10E10.3
1 of 14
No
No
Cele\T11F9.1
1 of 14
No
Yes
Cele\tkr-1
1 of 14
No
No
Cele\tkr-2
1 of 14
No
No
Cele\tkr-3
1 of 14
No
No
Cele\trhr-1
1 of 14
No
No
Cele\tyra-2
1 of 14
No
No
Cele\tyra-3
1 of 14
No
No
Cele\Y70D2A.1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (66)
Agam\GPRDOP1
12 of 12
Yes
Yes
Agam\GPRNNA10
2 of 12
No
No
Agam\AgaP_AGAP000606
1 of 12
No
No
Agam\AgaP_AGAP002229
1 of 12
No
No
Agam\AgaP_AGAP004122
1 of 12
No
No
Agam\AgaP_AGAP004930
1 of 12
No
No
Agam\AgaP_AGAP005229
1 of 12
No
No
Agam\AgaP_AGAP011320
1 of 12
No
No
Agam\AgaP_AGAP012982
1 of 12
No
No
Agam\AgaP_AGAP013324
1 of 12
No
No
Agam\GPR5HT1A
1 of 12
No
No
Agam\GPR5HT1B
1 of 12
No
No
Agam\GPR5HT2A
1 of 12
No
No
Agam\GPR5HT7
1 of 12
No
No
Agam\GPRADS
1 of 12
No
No
Agam\GPRALS2
1 of 12
No
No
Agam\GPRALS3
1 of 12
No
No
Agam\GPRCCK1
1 of 12
No
No
Agam\GPRCCK2
1 of 12
No
No
Agam\GPRDOP2
1 of 12
No
No
Agam\GPRDOP3
1 of 12
No
No
Agam\GPRGHP1
1 of 12
No
No
Agam\GPRGHP2
1 of 12
No
No
Agam\GPRGHP3
1 of 12
No
No
Agam\GPRGNR1
1 of 12
No
No
Agam\GPRGNR3
1 of 12
No
No
Agam\GPRGRP2
1 of 12
No
No
Agam\GPRLKK
1 of 12
No
No
Agam\GPRMAC1
1 of 12
No
No
Agam\GPRMAC2
1 of 12
No
No
Agam\GPRMTN
1 of 12
No
No
Agam\GPRNNA1
1 of 12
No
No
Agam\GPRNNA2
1 of 12
No
No
Agam\GPRNNA3
1 of 12
No
No
Agam\GPRNNA4
1 of 12
No
No
Agam\GPRNNA5
1 of 12
No
No
Agam\GPRNNA7
1 of 12
No
No
Agam\GPRNNA11
1 of 12
No
No
Agam\GPRNNA15
1 of 12
No
No
Agam\GPRNNA17
1 of 12
No
No
Agam\GPRNNA20
1 of 12
No
No
Agam\GPRNNA21
1 of 12
No
No
Agam\GPRNPR1
1 of 12
No
No
Agam\GPRNPR2
1 of 12
No
No
Agam\GPRNPY1
1 of 12
No
No
Agam\GPRNPY2
1 of 12
No
No
Agam\GPRNPY3
1 of 12
No
No
Agam\GPRNPY4
1 of 12
No
No
Agam\GPROAR1
1 of 12
No
No
Agam\GPROAR2
1 of 12
No
No
Agam\GPROP1
1 of 12
No
No
Agam\GPROP3
1 of 12
No
No
Agam\GPROP5
1 of 12
No
No
Agam\GPROP6
1 of 12
No
No
Agam\GPROP7
1 of 12
No
No
Agam\GPROP8
1 of 12
No
No
Agam\GPROP9
1 of 12
No
No
Agam\GPROP10
1 of 12
No
No
Agam\GPROP11
1 of 12
No
No
Agam\GPROP12
1 of 12
No
Yes
Agam\GPROPDR
1 of 12
No
No
Agam\GPRSMS
1 of 12
No
No
Agam\GPRTAK1
1 of 12
No
No
Agam\GPRTAK2
1 of 12
No
No
Agam\GPRTYR
1 of 12
No
No
Agam\GPRVPR1
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Dop1R1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (62)
5-HT2B
3 of 13
mAChR-A
3 of 13
mAChR-B
3 of 13
Oamb
3 of 13
5-HT1A
2 of 13
5-HT1B
2 of 13
5-HT2A
2 of 13
5-HT7
2 of 13
CG13579
2 of 13
Dop1R2
2 of 13
Dop2R
2 of 13
DopEcR
2 of 13
mAChR-C
2 of 13
Octβ1R
2 of 13
Octβ3R
2 of 13
Oct-TyrR
2 of 13
TyrRII
2 of 13
TyrR
2 of 13
AdoR
1 of 13
AkhR
1 of 13
AstA-R1
1 of 13
AstA-R2
1 of 13
AstC-R1
1 of 13
AstC-R2
1 of 13
CapaR
1 of 13
CCHa1-R
1 of 13
CCHa2-R
1 of 13
CCKLR-17D1
1 of 13
CCKLR-17D3
1 of 13
CG4313
1 of 13
CG12290
1 of 13
CG15614
1 of 13
CG30340
1 of 13
CG33639
1 of 13
CNMaR
1 of 13
ETHR
1 of 13
FMRFaR
1 of 13
GulpR
1 of 13
Lgr1
1 of 13
Lkr
1 of 13
moody
1 of 13
ninaE
1 of 13
Octα2R
1 of 13
Octβ2R
1 of 13
Pgr
1 of 13
PK1-R
1 of 13
PK2-R1
1 of 13
PK2-R2
1 of 13
Proc-R
1 of 13
Rh2
1 of 13
Rh3
1 of 13
Rh4
1 of 13
Rh5
1 of 13
Rh6
1 of 13
Rh7
1 of 13
RYa-R
1 of 13
SIFaR
1 of 13
sNPF-R
1 of 13
TkR86C
1 of 13
TkR99D
1 of 13
Tre1
1 of 13
TrissinR
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
Dop1R1HMC02344
model of  alcohol use disorder
CEA
(Kanno et al., 2021)
Dop1R1UAS.cKa
model of  depressive disorder
CEA
(Jia et al., 2021)
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
DRD5; dopamine receptor D5
model of  attention deficit hyperactivity disorder
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 2 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
DRD1; dopamine receptor D1
10 of 14
126449
       
      DRD5; dopamine receptor D5
      9 of 14
      126453
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Dop1R1
      enhanceable
      Dop1R2
      (Fernandez-Chiappe et al., 2020)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Dop1R2
      enhanceable
      Dop1R1
      (Fernandez-Chiappe et al., 2020)
      DopEcR
      suppressible
      Dop1R1
      (Petruccelli et al., 2016)
      mir-276a
      suppressible
      Dop1R1
      (Li et al., 2013)
      TrpA1
      suppressible
      Dop1R1
      (Sun et al., 2018, Liu et al., 2012, Liu et al., 2012)
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-54
      Cytogenetic map
      88A10-88A12
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      88A10-88A12
      Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      88-89
      (Gibson, 1999.7.26)
      35E-35F
      (determined by in situ hybridisation)
      (Gotzes et al., 1994)
      Experimentally Determined Recombination Data
      Location

      3-54

      (FlyBase, 2016)

      3-52.8

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (69)
      Genomic Clones (25)
      cDNA Clones (7)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Kong et al., 2010, Lebestky et al., 2009)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              Certain domains of receptor molecules may vary significantly in different strains of Drosophila but the structural changes do not alter the functional properties of the expressed polypeptides.

              (Gotzes and Baumann, 1996)

              A DopR cDNA has been cloned and sequenced.

              (Sugamori et al., 1995)
              Relationship to Other Genes
              Source for database merge of
              Additional comments

              nAcRα-34E is not DopR.

              (Ashburner et al., 1999.10.12)
              Nomenclature History
              Source for database identify of

              Source for identity of: DopR CG9652

              (Zheng, 1999.11)

              Source for identity of: Dop1R1 DopR

              (FlyBase, 2009-)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (35)
              Reported As
              Symbol Synonym
              CG9652
              (Mao et al., 2024, Ashraf et al., 2020, Kondo et al., 2020, Park et al., 2018, Meadows, 2017.1.11, Yu et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Selcho et al., 2009, Johnson et al., 2008, Ni et al., 2008, Hauser et al., 2006, Srivastava et al., 2005)
              D-Dop1
              (Gotzes et al., 1994)
              D1R1
              (Akiba et al., 2020)
              DA1
              (Dylla et al., 2013, Seugnet et al., 2009, Park et al., 2004)
              DOP1R1
              (Corrales et al., 2022)
              DR1
              (Stern et al., 2019, Yang et al., 2015)
              DRD1
              (Jia et al., 2016)
              DmDOP1
              (Qi et al., 2017, Yuan and Lee, 2007)
              DmDop1
              (Kong et al., 2010, Hearn et al., 2002, Gotzes and Baumann, 1996)
              Dmdop1
              (Kehren and Baumann, 2005, Blenau and Baumann, 2001)
              Dop1-R1
              (Ko et al., 2017, Suh et al., 2017)
              Dop1R
              (Byrns et al., 2024, Kottler et al., 2019)
              Dop1R1
              (Avishai and Parnas, 2025, Gao et al., 2025, Hakim et al., 2025, Kajtor et al., 2025, Shi et al., 2025, Song et al., 2025, Larnerd et al., 2024, Lin et al., 2024, Otenaike et al., 2024, Peng et al., 2024, Pollex et al., 2024, Qu et al., 2024, Anthoney et al., 2023, Bossen et al., 2023, Corthals et al., 2023, Godfrey et al., 2023, Rajagopalan et al., 2023, Wang et al., 2023, Beaver et al., 2022, Deshpande et al., 2022, Kapoor et al., 2022, Philyaw et al., 2022, Qiao et al., 2022, Raouf Issa et al., 2022, Saitoe et al., 2022, Schlichting et al., 2022, Yoon et al., 2022, Ahn et al., 2021, Ceder et al., 2021, El Kholy et al., 2021, Evans et al., 2021, McLaughlin et al., 2021, Nässel, 2021, Sareen et al., 2021, Scaplen and Petruccelli, 2021, Siju et al., 2021, Wei et al., 2021, Ashraf et al., 2020, Chakravarti Dilley et al., 2020, Chvilicek et al., 2020, Gao et al., 2020, Honegger et al., 2020, Jakšić et al., 2020, Karam et al., 2020, Kondo et al., 2020, Petruccelli et al., 2020, Scaplen et al., 2020, Brunet Avalos et al., 2019, Deng et al., 2019, Donlea, 2019, Kottler et al., 2019, Meltzer et al., 2019, Rao and Deng, 2019.10.23, Shih et al., 2019, Croset et al., 2018, Landayan et al., 2018, Park et al., 2018, Pu et al., 2018, Pu et al., 2018, Sun et al., 2018, Branco et al., 2017, Ferguson et al., 2017, Park et al., 2017, Tomita et al., 2017, Clandinin and Owens, 2016-, Pimentel et al., 2016, Gene Disruption Project members, 2015-, Grotewiel and Bettinger, 2015, Morgante et al., 2015, Shankar et al., 2015)
              DopR
              (Tawa and Notterman, 2025, Dai et al., 2024, Zirin et al., 2024, Bourouliti and Skoulakis, 2022, Braco et al., 2022, Highfill et al., 2019, Li et al., 2019, Ly et al., 2018, Ueno et al., 2017, Zajitschek et al., 2017, Crocker et al., 2016, Petruccelli et al., 2016, Pitmon et al., 2016, Zhang et al., 2016, de Taffin et al., 2015, Shih et al., 2015, Tomita et al., 2015, Ashwal-Fluss et al., 2014, Singh et al., 2014, Zhang et al., 2014, Alekseyenko et al., 2013, Argue and Neckameyer, 2013, Argue and Neckameyer, 2013, Dubnau and Chiang, 2013, Kottler et al., 2013, Li et al., 2013, Perisse et al., 2013, Ueno et al., 2013, Wang et al., 2013, Chen et al., 2012, Gruntenko et al., 2012, Izutsu et al., 2012, Kahsai et al., 2012, Kaun et al., 2012, Liu et al., 2012, Marella et al., 2012, Neckameyer and Bhatt, 2012, Rauschenbach et al., 2012, Bang et al., 2011, Jungreis et al., 2011, Kong et al., 2010, Lebestky et al., 2009, Hoopfer et al., 2008, Johnson et al., 2008, Baumgardt et al., 2007, Baumgardt et al., 2007, Dietzl et al., 2007, Draper et al., 2007, Jones, 2007, Franchini et al., 2004)
              DopR1
              (Wang et al., 2025, Bobrovskikh and Gruntenko, 2023, Pan et al., 2022, Driscoll et al., 2021, Dvořáček and Kodrík, 2021, Raun et al., 2021, Zhang et al., 2021, Zhang et al., 2021, Ahmad et al., 2020, Kondo et al., 2020, Mazzotta et al., 2020, Nässel and Zandawala, 2020, Texada et al., 2020, Awata et al., 2019, Dag et al., 2019, Handler et al., 2019, Lyutova et al., 2019, Karim et al., 2018, Xie et al., 2018, Lark et al., 2017, Liu et al., 2017, Koenig et al., 2016, Zhang et al., 2016, Cohn et al., 2015, Krüttner et al., 2015, Landayan and Wolf, 2015, Metaxakis et al., 2014, Crickmore and Vosshall, 2013, Perry and Barron, 2013, Inagaki et al., 2012, Keleman et al., 2012, Lebestky et al., 2009)
              DopR35F
              (Feng et al., 1996)
              Dumb
              (Sun et al., 2018, Zhang et al., 2016)
              dDA1
              (Davis, 2023, Noyes and Davis, 2023, Zhao et al., 2019, Medina, 2018, Aranda et al., 2017, Hattori et al., 2017, Himmelreich et al., 2017, Pitmon et al., 2016, Cassar et al., 2015, Davis, 2015, Dissel et al., 2015, Donlea et al., 2014, Perisse et al., 2013, Perry and Barron, 2013, Seugnet et al., 2011, Kong et al., 2010, Lebestky et al., 2009, Liu et al., 2009, Selcho et al., 2009, Andretic et al., 2008, Seugnet et al., 2008, Kim et al., 2007, Park et al., 2004, Blenau and Baumann, 2001, Sugamori et al., 1995)
              dDA1/DmDOP1
              (Kim et al., 2003)
              dopr
              (Naganos et al., 2016)
              dumb
              (Filošević Vujnović et al., 2021, Melnattur et al., 2021, Kondo et al., 2020, Awata et al., 2019, Kottler et al., 2019, Kim et al., 2017, Koenig et al., 2016, Pitmon et al., 2016, Cassar et al., 2015, Musso et al., 2015, Shih et al., 2015, Donlea et al., 2014, Kottler et al., 2013, Waddell, 2013, Burke et al., 2012, Liu et al., 2012, Van Swinderen and Andretic, 2011, Zars, 2010, Selcho et al., 2009, Seugnet et al., 2009, Andretic et al., 2008, Seugnet et al., 2008, Kim et al., 2007)
              Name Synonyms
              D1 dopamine receptor
              (Dylla et al., 2013, Lebestky et al., 2009)
              D1-Like Dopamine Receptor
              (Kong et al., 2010)
              D1-like DA receptor
              (Kong et al., 2010)
              D1-like receptor
              (Rauschenbach et al., 2011, Gilbert et al., 2000)
              D1 dopamine receptor
              (Neckameyer and Bhatt, 2012)
              DA D1-like receptor
              (Srivastava et al., 2005)
              Dopamine 1-like receptor 1
              (Shafer, 2025)
              Dopamine receptor
              dDA1
              (Dissel et al., 2015)
              dopamine 1 receptor
              (Seugnet et al., 2009)
              dopamine D1 receptor
              (Rothenfluh and Heberlein, 2002)
              dopamine D1-like receptor
              (Seugnet et al., 2008, Niznik, 1995.3.2)
              dopamine receptor
              (Johnson et al., 2008, Jones, 2007, Baumann, 1994.1.21)
              dopaminergic receptor
              (Zhang et al., 2016)
              dumb
              (Pitmon et al., 2016, Faville et al., 2015)
              dumb DA receptor
              (Musso et al., 2015)
              Secondary FlyBase IDs
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 51 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Flygut - An atlas of the Drosophila adult midgut
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                References (338)