FlyBase Gene Report: Dmel\Mmp2

General Information

Symbol

Dmel\Mmp2

Species

D. melanogaster

Name

Matrix metalloproteinase 2

Annotation Symbol

CG1794

Feature Type

protein_coding_gene

FlyBase ID

FBgn0033438

Gene Model Status

Current

Stock Availability

55 publicly available

Enzyme Name (EC)

Gene Summary

Matrix metalloproteinase 2 (Mmp2) encodes a proteinase that cleaves proteins in the extracellular matrix. It contributes to remodeling the body plan during metamorphosis; matrix and tissue remodeling during axon fasciculation, dendritic reshaping, wound healing, and ovulation; and down-regulating follicle stem cell proliferation. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

l(2)02353, Dm2-MMP, dmmp2

Key Links

Genomic Location

Cytogenetic map

45F6-46A1

Sequence location

2R:9,611,139..9,683,858 [-]

Recombination map

2-61

RefSeq locus

NT_033778 REGION:9611139..9683858

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (36 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables endopeptidase activity

inferred from direct assay

(Wang and Page-McCaw, 2014)

enables metalloendopeptidase activity

inferred from direct assay

(LaFever et al., 2017, Llano et al., 2002)

inferred from mutant phenotype

(Miller et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables metalloendopeptidase activity

inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR021190

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN001303987

(GO Reference Genome Project, 2011-)

enables metallopeptidase activity

inferred from electronic annotation with InterPro:IPR006026, InterPro:IPR024079, InterPro:IPR033739

(InterPro Project Members, 2004-)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR006026, InterPro:IPR021190, InterPro:IPR033739

(InterPro Project Members, 2004-)

Biological Process (27 terms)

Terms Based on Experimental Evidence (24 terms)

CV Term

Evidence

References

involved_in activation of innate immune response

inferred from direct assay

(Schmidt et al., 2011)

involved_in adult fat body development

inferred from mutant phenotype

(Jia et al., 2014)

involved_in basement membrane disassembly

inferred from mutant phenotype

(Srivastava et al., 2007)

involved_in basement membrane organization

inferred from mutant phenotype

(Guha et al., 2009)

involved_in cardioblast migration to the midline involved in heart rudiment formation

inferred from mutant phenotype

(Raza et al., 2017)

involved_in cell-cell junction organization

inferred from mutant phenotype

(Jia et al., 2014)

involved_in embryonic heart tube formation

inferred from mutant phenotype

(Raza et al., 2017)

involved_in fasciculation of motor neuron axon

inferred from mutant phenotype

(Miller et al., 2008)

involved_in imaginal disc eversion

inferred from mutant phenotype

(Srivastava et al., 2007)

involved_in imaginal disc fusion, thorax closure

inferred from mutant phenotype

(Uhlirova and Bohmann, 2006)

involved_in lateral inhibition

inferred from mutant phenotype

(Wang et al., 2010)

involved_in motor neuron axon guidance

inferred from mutant phenotype

(Miller et al., 2008)

involved_in negative regulation of canonical Wnt signaling pathway

inferred from genetic interaction with FLYBASE:arm; FB:FBgn0000117

(Wang and Page-McCaw, 2014)

inferred from genetic interaction with FLYBASE:wg; FB:FBgn0284084

(Wang and Page-McCaw, 2014)

involved_in negative regulation of extracellular matrix assembly

inferred from mutant phenotype

(Raza et al., 2017)

involved_in negative regulation of fibroblast growth factor receptor signaling pathway

inferred from direct assay

(Wang et al., 2010)

involved_in negative regulation of stem cell proliferation

inferred from mutant phenotype

(Wang and Page-McCaw, 2014)

involved_in open tracheal system development

inferred from mutant phenotype

(Wang et al., 2010)

involved_in ovulation

inferred from mutant phenotype

(Deady et al., 2015)

involved_in protein processing

inferred from mutant phenotype

(Casas-Tintó et al., 2015)

involved_in substrate-dependent cell migration

inferred from mutant phenotype

(Raza et al., 2017)

involved_in tracheal outgrowth, open tracheal system

inferred from mutant phenotype

(Guha et al., 2009)

involved_in tracheal pit formation in open tracheal system

inferred from mutant phenotype

(Guha et al., 2009)

involved_in ventral cord development

inferred from mutant phenotype

(Meyer et al., 2014)

involved_in wound healing

inferred from mutant phenotype

(Stevens and Page-McCaw, 2012)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in collagen catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN001303987

(GO Reference Genome Project, 2011-)

involved_in extracellular matrix organization

inferred from biological aspect of ancestor with PANTHER:PTN001303987

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR006026, InterPro:IPR021190

(InterPro Project Members, 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in dendrite

inferred from mutant phenotype

(Kuo et al., 2005)

located_in external side of plasma membrane

inferred from direct assay

(Wang and Page-McCaw, 2014)

located_in extracellular space

inferred from direct assay

(LaFever et al., 2017)

located_in plasma membrane

inferred from direct assay

(LaFever et al., 2017, Llano et al., 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in extracellular matrix

inferred from electronic annotation with InterPro:IPR001818

(InterPro Project Members, 2004-)

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN002565698

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

MATRIX METALLOPROTEASES

Pathway (FlyBase)

NEGATIVE REGULATORS OF FGFR SIGNALING PATHWAY

NEGATIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY

Protein Family (UniProt)

Belongs to the peptidase M10A family. (Q8MPP3)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

metalloendopeptidase activity

Summaries

Gene Snapshot

Pathway (FlyBase)

NEGATIVE REGULATORS OF FGFR SIGNALING PATHWAY -: Negative regulators of Fibroblast Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on other effectors.
NEGATIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY -: Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).

Gene Group (FlyBase)

MATRIX METALLOPROTEASES -: Matrix metalloproteases (MMPs) belong to MEROPS family M10 and also to the group of peptidases known as the "metzincins", due to a conserved methionine C-terminal to the zinc ligands. They are secreted proteins that function extracellularly. They play important roles in the degradation of extracellular matrix proteins and altering signaling pathways. There are over 20 MMPs in vertebrates, but only 2 in D. melanogaster, which cleave different substrates. (Adapted from FBrf0235071 and FBrf0239469.)

Protein Function (UniProtKB)

Has metalloproteinase activity (PubMed:11967260). Proteolytically cleaves the PGRP-LC receptor; involved in gut-fat body innate immunological communication (GFIC)-mediated activation of the imd/Relish signal transduction pathway (PubMed:22262460, PubMed:31350199). Required for larval tissue histolysis during metamorphosis and is involved in pupal head eversion and fusion of the wing imaginal tissue (PubMed:12530966). Required for growth of the dorsal air sac primordium and development of the dorsal air sacs (PubMed:19751719). Promotes embryonic motor axon fasciculation (PubMed:18045838). Cleaves and activates frac to promote motor axon bundling during outgrowth (PubMed:21471368). Promotes the reshaping of adult sensory neuron dendrites from a radial to lattice-like shape which occurs after eclosion by degrading the basement membrane on which the dendrites grow (PubMed:20412776). Involved in inhibition of follicle stem cell proliferation by cleaving Dlp, inhibiting its interaction with wg and preventing Dlp-mediated spreading of wg to follicle stem cells to enhance their proliferation (PubMed:25267296). Plays a role in wound healing (PubMed:22262460). Involved in fat body dissociation which occurs during metamorphosis by degrading basement membrane components, leading to destruction of cell-basement membrane junctions (PubMed:25520167). Required for posterior follicle cell degradation and ovulation (PubMed:25695427).

(UniProt, Q8MPP3)

Summary (Interactive Fly)

enzymes required for several stereotyped motor axon pathfinding decisions and essential for axon fasciculation - Mmp2 promotes dendrite reshaping through local degradation of the basement membrane - in trachea Mmp2 inhibits FGF morphogenetic function - Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Mmp2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8MPP3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Mmp2-RB

FBtr0088501

NM_206066

4156

758

Mmp2-RC

FBtr0334807

NM_001273901

3412

606

Mmp2-RD

FBtr0334808

NM_136667

3684

650

Additional Transcript Data and Comments

Reported size (kB)

3.4 (sequence analysis)

(Llano et al., 2002)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Mmp2-PB

FBpp0087585

89.1

758

8.81

FBpp0306848

72.1

606

8.74

NP_001260830

AGB93363

Mmp2-PD

FBpp0306849

77.3

650

9.25

NP_610511

AAF58911

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

758 (aa); 89 (kD predicted)

(Llano et al., 2002)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q8MPP3

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mmp2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.71

Transcript Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

midline glial cell

(Miller et al., 2008)

larval glial cell | subset

(Miller et al., 2008)

larval neuron | subset

(Miller et al., 2008)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10 -- 12

mesoderm

(Page-McCaw et al., 2003)

embryonic stage 10 -- 14

embryonic/larval stomatogastric nervous system

(Page-McCaw et al., 2003)

larval peripheral nervous system

(Page-McCaw et al., 2003)

embryonic stage 14 -- 16

larval central nervous system | segmentally repeated

(Page-McCaw et al., 2003)

embryonic stage 15

embryonic midgut constriction

(Page-McCaw et al., 2003)

embryonic stage 17

larval brain | restricted

(Page-McCaw et al., 2003)

larval ventral nerve cord | restricted

(Page-McCaw et al., 2003)

third instar larval stage

embryonic/larval optic lobe

(Llano et al., 2002)

larval brain

(Llano et al., 2002)

wing disc

(Llano et al., 2002)

lamina

(Llano et al., 2002)

eye disc posterior to the morphogenetic furrow

(Llano et al., 2002)

wandering third instar larval stage

wing disc

(Page-McCaw et al., 2003)

leg disc

(Page-McCaw et al., 2003)

eye disc morphogenetic furrow

(Page-McCaw et al., 2003)

ommatidium

(Page-McCaw et al., 2003)

larval ventral nerve cord

(Page-McCaw et al., 2003)

larval brain

(Page-McCaw et al., 2003)

embryonic/larval optic lobe

(Page-McCaw et al., 2003)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage & larval stage & pupal stage

(Llano et al., 2002)

embryonic stage -- pupal stage

organism

(Llano et al., 2002)

third instar larval stage

lamina

(Llano et al., 2002)

wing disc

(Llano et al., 2002)

embryonic/larval optic lobe

(Llano et al., 2002)

eye disc

(Llano et al., 2002)

eye disc posterior to the morphogenetic furrow

(Llano et al., 2002)

adult stage | female

(Llano et al., 2002)

organism

(Llano et al., 2002)

adult stage | male

(Llano et al., 2002)

organism

(Llano et al., 2002)

Additional Descriptive Data

Mmp2 is widely expressed in the embryonic CNS. At stage 15, it is expressed in the midline glia and in approximately three other glial cells per hemisegment (as identified by repo expression, situated at the base of the motor nerve roots. These may correspond to the exit glia. Mmp2 is also expressed in a subset of neurons in the embyronic CNS including the tup-expressing neurons.

(Miller et al., 2008)

Mmp2 is expressed in many tissues from stage 10 including the mesoderm, stomatogastric nervous system, ectoderm, and the peripheral nervous system. Starting in stage 14, it is expressed in segmentally repeated cells in the developing central nervous system. It is expressed in gut constrictions in stages 15 and 16 and in the embryonic brain by stage 17. In wandering third instar larvae, Mmp2 is expressed widely in the wing disc, less in leg disc, and abundantly in the morphogenetic furrow and in developing ommatidia. Expression occurs in discrete foci throughout the ventral nerve cord and brain lobes and is strong in the optic lobe.

(Page-McCaw et al., 2003)

Mmp2 transcripts are detected in embryos, larvae, pupae, and adult males and females by RT-PCR. They are not detected by northern blot. They are observed by in situ hybridization in third instar larval imaginal discs and brain. Strong expression is seen in the eye disc behind the morphogenetic furrow and in the lamina.

(Llano et al., 2002)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Mmp2 protein localizes to the cell membrane.

(Llano et al., 2002)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in dendrite

inferred from mutant phenotype

(Kuo et al., 2005)

located_in external side of plasma membrane

inferred from direct assay

(Wang and Page-McCaw, 2014)

located_in extracellular space

inferred from direct assay

(LaFever et al., 2017)

located_in plasma membrane

inferred from direct assay

(LaFever et al., 2017, Llano et al., 2002)

Expression Deduced from Reporters

Reporter: P{GawB}Mmp2^NP0509

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

peripodial stalk of wing disc

(Srivastava et al., 2007)

air sac primordium | distal

(Wang et al., 2010)

air sac primordium tip cell

(Wang et al., 2010)

CNS surface glial cell

(Olson et al., 2019)

eye photoreceptor precursor cell

(Olson et al., 2019)

day 1 of adulthood

epithelium

(Yasunaga et al., 2010)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Mmp2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Mmp2

View exonic expression by tissue for Dmel\Mmp2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35997/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033438

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033438

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033438

Flygut - An atlas of the Drosophila adult midgut

FBgn0033438

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 125 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 17 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Mmp2

Transgenic constructs containing regulatory region of Mmp2

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene not disrupted in

Df(2R)B5

(BDGP Project Members, 1994-1999)

Df(2R)Np4

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)Np5

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Gene disrupted in

Df(2R)BSC132

(Christensen and Cook, 2005.12.14)

Df(2R)Uba1-Mmp2

(Page-McCaw et al., 2003)

Gene partially disrupted in

Df(2R)mir-307a-307b-KO

(Chen et al., 2014)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Gli-rL82.4

Mmp2^UAS.cPa

lethal, with Scer\GAL4^moody.SPG

Mmp2^UAS.cPa

lethal | pupal stage

Mmp2^W307stop

lethal | recessive

lethal - all die before end of larval stage, with Scer\GAL4^Gli-rL82.4

Mmp2^E258A.UAS

lethal - all die before end of larval stage, with Scer\GAL4^moody.SPG

Mmp2^E258A.UAS

lethal - all die before end of larval stage, with Scer\GAL4^repo.PU

Mmp2^E258A.UAS

lethal - all die before end of pupal stage

lethal - all die before end of pupal stage (with Df(2R)Uba1-Mmp2)

Mmp2^W307stop

lethal - all die before end of pupal stage (with Mmp2^A218V)

Mmp2^Df

lethal - all die before end of pupal stage (with Mmp2^Df)

lethal - all die before end of pupal stage (with Mmp2^G535R)

Mmp2^Df

lethal - all die before end of pupal stage (with Mmp2^W307stop)

Mmp2^Df

lethal - all die during embryonic stage, with Scer\GAL4^Cg.PA

Mmp2^UAS.cPa

lethal - all die during embryonic stage, with Scer\GAL4^repo.PL, Scer\GAL4^repo.PU

Mmp2^UAS.cPa

partially lethal - majority die, with Scer\GAL4^yolk

Mmp2^UAS.cPa

partially lethal - majority die (with Mmp2^Df)

Mmp2^F219I

partially lethal - majority die (with Mmp2^F219I)

Mmp2^Df

partially lethal - majority die | larval stage

Mmp2^W307stop

viable, with Scer\GAL4^GMR71G10, Spyo\Cas9^{UAS.Tag:NLS(Unk)}

Mmp2^WKO.3-C7

Sterility

Allele

female semi-fertile, with Scer\GAL4^Act.PU

sterile, with Scer\GAL4^yolk

Mmp2^UAS.cPa

Other Phenotypes

Allele

abnormal cell migration | embryonic stage

Mmp2^W307stop

abnormal cell migration | embryonic stage, with Scer\GAL4^Mef2.PU

Mmp2^NIG.1794-1R

abnormal cell shape | embryonic stage

Mmp2^W307stop

abnormal cell shape | P-stage, with Scer\GAL4^GMR.PF

Mmp2^UAS.cPa

abnormal developmental rate, with Scer\GAL4^Lsp2.PH

Mmp2^KK104713

abnormal neuroanatomy | embryonic stage

Mmp2^W307stop

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^elav.PU

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^repo.PU

abnormal neuroanatomy | embryonic stage (with Df(2R)Uba1-Mmp2)

Mmp2^W307stop

abnormal neuroanatomy | pupal stage

Mmp2^W307stop

abnormal neuroanatomy | pupal stage, with Scer\GAL4^GMR71G10, Spyo\Cas9^{UAS.Tag:NLS(Unk)}

Mmp2^WKO.3-C7

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^c527

abnormal neuroanatomy | third instar larval stage | heat sensitive, with Scer\GAL4^repo.PL, Scer\GAL4^repo.PU, Scer\GAL80^ts.αTub84B

Mmp2^UAS.cPa

abnormal neurophysiology | adult stage | somatic clone

Mmp2^DG24601

decreased fecundity | female, with Scer\GAL4^Act.PU

Mmp2^RNAi.UAS

decreased fecundity | female, with Scer\GAL4^GMR42A05

Mmp2^RNAi.UAS

decreased fecundity | female, with Scer\GAL4^GMR47A04

Mmp2^RNAi.UAS

hyperplasia | third instar larval stage, with Scer\GAL4^ap-md544

Mmp2^RNAi.UAS

increased cell number | adult stage | female, with Scer\GAL4^bab1-Agal4-5, Scer\GAL4^ptc-559.1

Mmp2^NIG.1794-1R

increased cell number | adult stage | female, with Scer\GAL4^bab1-Pgal4-2

Mmp2^NIG.1794-1R

increased cell number | adult stage | female | heat sensitive (with Df(2R)BSC132)

Mmp2^Y53N

increased cell number | adult stage | female | heat sensitive (with Mmp2²¹⁸)

Mmp2^Y53N

increased cell number | adult stage | female | heat sensitive (with Mmp2⁰²³⁵³)

Mmp2^Y53N

increased cell number | adult stage | female | heat sensitive (with Mmp2^W307stop)

Mmp2^Y53N

increased cell number | adult stage | female | heat sensitive (with Mmp2^Y53N)

increased cell number | oogenesis | heat sensitive (with Df(2R)BSC132)

Mmp2^Y53N

increased cell number | oogenesis | heat sensitive (with Mmp2²¹⁸)

Mmp2^Y53N

increased cell number | oogenesis | heat sensitive (with Mmp2^W307stop)

Mmp2^Y53N

increased cell number | oogenesis | heat sensitive (with Mmp2^Y53N)

increased occurrence of cell division | adult stage | female, with Scer\GAL4^bab1-Pgal4-2

Mmp2^NIG.1794-1R

increased occurrence of cell division | adult stage | female | heat sensitive (with Mmp2^W307stop)

Mmp2^Y53N

increased occurrence of cell division | adult stage | female | heat sensitive (with Mmp2^Y53N)

Mmp2^W307stop

melanotic mass phenotype | pupal stage (with Mmp2^Df)

Mmp2^G535R

melanotic mass phenotype | pupal stage (with Mmp2^G535R)

Mmp2^Df

short lived (with Df(2R)BSC132)

Mmp2^Y53N

short lived (with Mmp2²¹⁸)

Mmp2^Y53N

short lived (with Mmp2^Y53N)

Mmp2²¹⁸

some die during embryonic stage, with Scer\GAL4^Cg.PA

Mmp2^UAS.cPa

some die during pupal stage

some die during pupal stage (with Df(2R)Uba1-Mmp2)

Mmp2^W307stop

some die during pupal stage (with Mmp2^A218V)

Mmp2^Df

some die during pupal stage (with Mmp2^Df)

some die during pupal stage (with Mmp2^F219I)

Mmp2^Df

some die during pupal stage (with Mmp2^G535R)

Mmp2^Df

some die during pupal stage (with Mmp2^W307stop)

Mmp2^Df

visible | adult stage, with Scer\GAL4^rn-GAL4-5

Phenotype manifest in

Allele

adult thorax, with Scer\GAL4^pnr-MD237

Mmp2^RNAi.UAS

adult tracheal air sac | third instar larval stage | heat sensitive, with Scer\GAL4^btl.PS, Scer\GAL80^ts.αTub84B

Mmp2^RNAi.UAS.cWa

axon | pupal stage, with Scer\GAL4^GMR71G10, Spyo\Cas9^{UAS.Tag:NLS(Unk)}

Mmp2^WKO.3-C7

basal part of cell | P-stage, with Scer\GAL4^GMR.PF

Mmp2^UAS.cPa

basement membrane | pupal stage

Mmp2^k00604

dendritic arborizing neuron | P-stage

Mmp2^W307stop

dorsal air sac primordium | third instar larval stage

Mmp2^W307stop

dorsal air sac primordium | third instar larval stage, with Scer\GAL4^ap-md544

Mmp2^RNAi.UAS

dorsal air sac primordium | third instar larval stage, with Scer\GAL4^btl.PS

Mmp2^RNAi.UAS

dorsal air sac primordium tip cell | third instar larval stage | heat sensitive, with Scer\GAL4^btl.PS, Scer\GAL80^ts.αTub84B

Mmp2^RNAi.UAS.cWa

egg chamber, with Scer\GAL4^Act.PU

Mmp2^RNAi.UAS

egg chamber, with Scer\GAL4^GMR47A04

Mmp2^UAS.cPa

embryonic/larval proventriculus | P-stage

Mmp2^W307stop

embryonic/larval tracheal transverse connective | third instar larval stage

Mmp2^W307stop

embryonic/larval tracheal transverse connective | third instar larval stage, with Scer\GAL4^btl.PS

Mmp2^RNAi.UAS

embryonic heart cardioblast

Mmp2^W307stop

embryonic heart cardioblast, with Scer\GAL4^Mef2.PU

extracellular matrix | third instar larval stage, with Scer\GAL4^c527

eye | somatic clone

Mmp2^DG24601

fat body, with Scer\GAL4^Lsp2.PH

Mmp2^KK104713

filopodium | embryonic stage

Mmp2^W307stop

filopodium | embryonic stage, with Scer\GAL4^Mef2.PU

follicle cell, with Scer\GAL4^Act.PU

Mmp2^RNAi.UAS

follicle cell, with Scer\GAL4^GMR47A04

Mmp2^UAS.cPa

follicle stem cell | heat sensitive (with Mmp2^W307stop)

Mmp2^Y53N

follicle stem cell | heat sensitive (with Mmp2^Y53N)

Mmp2^W307stop

gamma Kenyon cell | pupal stage, with Scer\GAL4^GMR71G10, Spyo\Cas9^{UAS.Tag:NLS(Unk)}

Mmp2^WKO.3-C7

gastric caecum | P-stage

Mmp2^W307stop

germarium region 2b, with Scer\GAL4^bab1-Pgal4-2

Mmp2^NIG.1794-1R

germarium region 2b | heat sensitive (with Mmp2^W307stop)

Mmp2^Y53N

germarium region 2b | heat sensitive (with Mmp2^Y53N)

Mmp2^W307stop

haltere | adult stage, with Scer\GAL4^rn-GAL4-5

haltere | P-stage, with Scer\GAL4^rn-GAL4-5

Mmp2^KK104713

head | pupal stage (with Df(2R)Uba1-Mmp2)

Mmp2^W307stop

heart primordium

Mmp2^W307stop

heart primordium, with Scer\GAL4^Mef2.PU

interommatidial bristle, with Scer\GAL4^GMR.PF

Mmp2^UAS.cPa

lamellipodium | embryonic stage

Mmp2^W307stop

lamellipodium | embryonic stage, with Scer\GAL4^Mef2.PU

Mmp2^NIG.1794-1R

larval brain | third instar larval stage | heat sensitive, with Scer\GAL4^repo.PL, Scer\GAL4^repo.PU, Scer\GAL80^ts.αTub84B

Mmp2^UAS.cPa

larval intersegmental nerve branch ISNb of A1-7

Mmp2^W307stop

larval intersegmental nerve branch ISNb of A1-7, with Scer\GAL4^elav.PU

larval intersegmental nerve branch ISNb of A1-7, with Scer\GAL4^repo.PU

larval intersegmental nerve branch ISNb of A1-7 (with Df(2R)Uba1-Mmp2)

Mmp2^W307stop

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage

Mmp2^W307stop

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage, with Scer\GAL4^repo.PU

Mmp2^UAS.cPa

larval segmental nerve branch SNa of A1-7

Mmp2^W307stop

larval segmental nerve branch SNa of A1-7, with Scer\GAL4^elav.PU

Mmp2^UAS.cPa

larval segmental nerve branch SNa of A1-7, with Scer\GAL4^repo.PU

Mmp2^UAS.cPa

larval segmental nerve branch SNa of A1-7 (with Df(2R)Uba1-Mmp2)

Mmp2^W307stop

larval segmental nerve branch SNa of A1-7 | embryonic stage, with Scer\GAL4^repo.PU

Mmp2^UAS.cPa

larval ventral nerve cord | third instar larval stage, with Scer\GAL4^c527

larval ventral nerve cord | third instar larval stage | heat sensitive, with Scer\GAL4^repo.PL, Scer\GAL4^repo.PU, Scer\GAL80^ts.αTub84B

Mmp2^UAS.cPa

leg | pupal stage

Mmp2^k00604

mesonotum | pharate adult stage

Mmp2^A218V

ommatidium, with Scer\GAL4^GMR.PF

Mmp2^UAS.cPa

ovarian basement membrane | oogenesis stage S14, with Scer\GAL4^GMR47A04

Mmp2^RNAi.UAS

retina | P-stage, with Scer\GAL4^GMR.PF

Mmp2^UAS.cPa

retina | somatic clone

Mmp2^DG24601

stalk follicle cell, with Scer\GAL4^C587

Mmp2^UAS.cPa

stalk follicle cell | increased number, with Scer\GAL4^bab1-Agal4-5, Scer\GAL4^ptc-559.1

Mmp2^NIG.1794-1R

stalk follicle cell | increased number, with Scer\GAL4^bab1-Pgal4-2

stalk follicle cell | increased number | heat sensitive (with Df(2R)BSC132)

stalk follicle cell | increased number | heat sensitive (with Mmp2²¹⁸)

Mmp2^Y53N

stalk follicle cell | increased number | heat sensitive (with Mmp2⁰²³⁵³)

Mmp2^Y53N

stalk follicle cell | increased number | heat sensitive (with Mmp2^W307stop)

Mmp2^Y53N

stalk follicle cell | increased number | heat sensitive (with Mmp2^Y53N)

wing, with Scer\GAL4^rn-GAL4-5

Mmp2^KK104713

wing | pupal stage

Mmp2^k00604

wing disc | P-stage, with Scer\GAL4^rn-GAL4-5

Mmp2^KK104713

wing disc | third instar larval stage

Mmp2^W307stop

wing disc | third instar larval stage, with Scer\GAL4^btl.PS

Mmp2^RNAi.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (29)

Hsap\MMP15

8 of 14

Yes

Hsap\MMP14

7 of 14

Hsap\MMP16

7 of 14

Hsap\MMP17

7 of 14

Yes

Hsap\MMP24

7 of 14

Hsap\MMP7

6 of 14

Yes

Hsap\MMP25

6 of 14

Yes

Hsap\MMP1

5 of 14

Hsap\MMP2

5 of 14

Yes

Hsap\MMP3

5 of 14

Hsap\MMP8

5 of 14

Hsap\MMP9

5 of 14

Yes

Hsap\MMP10

5 of 14

Hsap\MMP11

5 of 14

Yes

Hsap\MMP12

5 of 14

Hsap\MMP13

5 of 14

Hsap\MMP19

5 of 14

Yes

Hsap\MMP20

5 of 14

Hsap\MMP27

5 of 14

Hsap\MMP28

5 of 14

Yes

Hsap\MMP21

4 of 14

Yes

Hsap\MMP26

4 of 14

Hsap\MMP23B

3 of 14

Yes

Hsap\ELSPBP1

2 of 14

Yes

Hsap\HPX

2 of 14

Yes

Hsap\PRG4

2 of 14

Yes

Hsap\VTN

2 of 14

Yes

Hsap\BSPH1

1 of 14

Yes

Hsap\MMP23A

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (25)

Rnor\Mmp14

8 of 14

Yes

Rnor\Mmp15

8 of 14

Yes

Rnor\Mmp16

8 of 14

Yes

Rnor\Mmp24

8 of 14

Yes

Rnor\Mmp17

7 of 14

Yes

Rnor\Mmp7

6 of 14

Yes

Rnor\Mmp8

6 of 14

Rnor\Mmp10

6 of 14

Rnor\Mmp11

6 of 14

Yes

Rnor\Mmp13

6 of 14

Yes

Rnor\Mmp20

6 of 14

Rnor\Mmp27

6 of 14

Rnor\Mmp1b

5 of 14

Yes

Rnor\Mmp1

5 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

Yes

Rnor\Mmp28

5 of 14

Yes

Rnor\Mmp9

4 of 14

Rnor\Mmp21

4 of 14

Yes

Rnor\Mmp23

3 of 14

Rnor\Hpx

2 of 14

Yes

Rnor\Prg4

2 of 14

Yes

Rnor\Vtn

2 of 14

Yes

Mus musculus (laboratory mouse) (28)

Mmus\Mmp14

8 of 14

Yes

Mmus\Mmp15

8 of 14

Yes

Mmus\Mmp16

8 of 14

Yes

Mmus\Mmp17

8 of 14

Yes

Mmus\Mmp24

8 of 14

Yes

Mmus\Mmp25

7 of 14

Yes

Mmus\Mmp1b

6 of 14

Yes

Mmus\Mmp8

6 of 14

Mmus\Mmp11

6 of 14

Yes

Mmus\Mmp13

6 of 14

Yes

Mmus\Mmp20

6 of 14

Mmus\Mmp1a

5 of 14

Yes

Mmus\Mmp2

5 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

Yes

Mmus\Mmp27

5 of 14

Mmus\Mmp28

5 of 14

Yes

Mmus\Mmp21

4 of 14

Yes

Mmus\Mmp9

3 of 14

Mmus\Mmp23

3 of 14

Mmus\Hpx

2 of 14

Yes

Mmus\Prg4

2 of 14

Yes

Mmus\Vtn

2 of 14

Yes

Mmus\Bsph1

1 of 14

Yes

Mmus\Bsph2

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (39)

Xtro\mmp15

7 of 13

Yes

Xtro\mmp16

7 of 13

Yes

Xtro\mmp17

7 of 13

Yes

Xtro\mmp25

6 of 13

Yes

Xtro\dph2

5 of 13

Xtro\LOC101731804

5 of 13

Yes

Xtro\mmp13

5 of 13

Yes

Xtro\mmp24

5 of 13

Xtro\LOC100491547

4 of 13

Xtro\LOC116408899

4 of 13

Yes

Xtro\mmp1

4 of 13

Yes

Xtro\mmp3

4 of 13

Xtro\mmp8

4 of 13

Yes

Xtro\mmp9.1

4 of 13

Yes

Xtro\mmp9.2

4 of 13

Yes

4 of 13

4 of 13

4 of 13

4 of 13

Yes

Xtro\mmp20

4 of 13

Xtro\mmp28

4 of 13

Yes

Xtro\usp19

4 of 13

Xtro\erfe

3 of 13

Yes

Xtro\LOC100489571

3 of 13

Yes

Xtro\LOC100489735

3 of 13

Yes

Xtro\LOC100491214

3 of 13

Yes

Xtro\mmp2

3 of 13

Yes

Xtro\mmp21

3 of 13

Yes

Xtro\mmp23b

3 of 13

Yes

Xtro\LOC100127856

2 of 13

Xtro\hpx

1 of 13

Yes

Xtro\LOC100489108

1 of 13

Yes

Xtro\LOC100489842

1 of 13

Yes

Xtro\LOC100492075

1 of 13

Yes

Xtro\LOC100493912

1 of 13

Yes

Xtro\LOC101731006

1 of 13

Xtro\mmp7

1 of 13

Yes

Xtro\trmt10a

1 of 13

Xtro\tspan17

1 of 13

Danio rerio (Zebrafish) (33)

Drer\mmp14a

8 of 14

Yes

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

Yes

Drer\mmp24

7 of 14

Drer\mmp25b

7 of 14

Yes

Drer\mmp25a

6 of 14

Yes

Drer\mmp2

5 of 14

Yes

Drer\mmp9

5 of 14

Yes

Drer\mmp11a

5 of 14

Drer\mmp11b

5 of 14

Drer\mmp19

5 of 14

Yes

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

Drer\mmp23bb

4 of 14

Yes

Drer\mmp28

4 of 14

Yes

Drer\hpxa

2 of 14

Yes

Drer\LOC100333071

2 of 14

Yes

Drer\mmp17b

2 of 14

Drer\mmp21

2 of 14

Drer\prg4a

2 of 14

Yes

Drer\vtna

2 of 14

Yes

Drer\vtnb

2 of 14

Yes

Drer\hpxb

1 of 14

Yes

Drer\mmp16a

1 of 14

Yes

Drer\prg4b

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\zmp-5

6 of 14

Yes

Cele\zmp-1

5 of 14

Yes

Cele\zmp-3

5 of 14

Cele\zmp-6

5 of 14

Cele\zmp-4

4 of 14

Yes

Cele\zmp-2

3 of 14

Yes

Cele\W01F3.2

2 of 14

Cele\Y50D7A.13

2 of 14

Cele\K03B8.6

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP011870

10 of 12

Yes

Agam\AgaP_AGAP003929

7 of 12

Yes

Agam\AgaP_AGAP011867

7 of 12

Yes

Agam\AgaP_AGAP006904

3 of 12

Agam\AgaP_AGAP005952

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (5)

Atha\AT1G24140

7 of 13

Yes

Atha\AT1G59970

7 of 13

Yes

Atha\AT2G45040

7 of 13

Yes

Atha\AT4G16640

7 of 13

Yes

Atha\MMP

7 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Mmp2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (4)

8 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

MMP21; matrix metallopeptidase 21

model of visceral heterotaxy 7

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 6 )

Allele

Disease

Interaction

References

Mmp2⁰²³⁵³

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Miller et al., 2010)

Mmp2^BG00958

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Miller et al., 2010)

Mmp2^RNAi.UAS

ameliorates intestinal cancer

modeled by Sox21a⁶

(Zhai et al., 2015)

ameliorates carcinoma

modeled by Ras85D^V12.UAS, scrib¹

(Uhlirova and Bohmann, 2006)

Mmp2^GD9489

exacerbates atypical teratoid rhabdoid tumor

modeled by Snr1^KK101602

(Tegeder et al., 2019)

Mmp2^KK104713

ameliorates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Portela et al., 2019)

Mmp2^HMJ23143

ameliorates hematologic cancer

modeled by mxc¹

(Takarada et al., 2023)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MMP15; matrix metallopeptidase 15

8 of 14

602261

MMP14; matrix metallopeptidase 14

7 of 14

600754

WINCHESTER SYNDROME; WNCHRS

Winchester syndrome

MMP16; matrix metallopeptidase 16

7 of 14

602262

MMP17; matrix metallopeptidase 17

7 of 14

602285

MMP24; matrix metallopeptidase 24

7 of 14

604871

MMP7; matrix metallopeptidase 7

6 of 14

178990

MMP25; matrix metallopeptidase 25

6 of 14

608482

MMP1; matrix metallopeptidase 1

5 of 14

120353

MMP2; matrix metallopeptidase 2

5 of 14

120360

MULTICENTRIC OSTEOLYSIS, NODULOSIS, AND ARTHROPATHY; MONA

MMP3; matrix metallopeptidase 3

5 of 14

185250

CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 6; CHDS6

MMP8; matrix metallopeptidase 8

5 of 14

120355

MMP9; matrix metallopeptidase 9

5 of 14

120361

METAPHYSEAL ANADYSPLASIA 2; MANDP2

MMP10; matrix metallopeptidase 10

5 of 14

185260

MMP11; matrix metallopeptidase 11

5 of 14

185261

MMP12; matrix metallopeptidase 12

5 of 14

601046

MMP13; matrix metallopeptidase 13

5 of 14

600108

spondyloepimetaphyseal dysplasia, Missouri type

MMP19; matrix metallopeptidase 19

5 of 14

601807

CAVITARY OPTIC DISC ANOMALIES; CODA

MMP20; matrix metallopeptidase 20

5 of 14

604629

AMELOGENESIS IMPERFECTA, HYPOMATURATION TYPE, IIA2; AI2A2

amelogenesis imperfecta hypomaturation type 2A2

MMP27; matrix metallopeptidase 27

5 of 14

618101

MMP28; matrix metallopeptidase 28

5 of 14

608417

MMP21; matrix metallopeptidase 21

4 of 14

608416

HETEROTAXY, VISCERAL, 7, AUTOSOMAL; HTX7

visceral heterotaxy 7

MMP26; matrix metallopeptidase 26

4 of 14

605470

MMP23B; matrix metallopeptidase 23B

3 of 14

603321

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Mmp2

bead aggregation assay, fluorescence microscopy, inferred by author

(LaFever et al., 2017)

Mmp2 - frac

two hybrid

(Miller et al., 2011)

Mmp2 - p53

pull down, autoradiography

(Lunardi et al., 2010)

Mmp2 - png

enzymatic study, molecular weight estimation by staining

(Lee et al., 2005)

Mmp2 - shg

enzymatic study, molecular weight estimation by staining

(Jia et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Mmp2

suppressible

arm

(Wang and Page-McCaw, 2014)

Mmp2

enhanceable

dlp

(Wang and Page-McCaw, 2014)

Mmp2

suppressible

dlp

(Wang and Page-McCaw, 2014)

Mmp2

suppressible

frac

(Miller et al., 2011)

Mmp2

enhanceable

frac

(Miller et al., 2011)

Mmp2

enhanceable

Mmp1

(Jia et al., 2014, Miller et al., 2008, Page-McCaw et al., 2003)

Mmp2

suppressible

Sema1a

(Miller et al., 2008)

Mmp2

suppressible

Timp

(Wang and Page-McCaw, 2014, Page-McCaw et al., 2003)

Mmp2

suppressible

(Wang and Page-McCaw, 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

frac

enhanceable

Mmp2

(Miller et al., 2011)

Gyc76C

suppressible

Mmp2

(Schleede and Blair, 2015)

Mmp1

enhanceable

Mmp2

(Miller et al., 2008, Page-McCaw et al., 2003)

mxc

suppressible

Mmp2

(Takarada et al., 2023)

Oamb

suppressible

Mmp2

(Deady and Sun, 2015)

PGRP-LE

suppressible

Mmp2

(Winkler et al., 2025)

Pi3K92E|btl::Egfr

suppressible

Mmp2

(Portela et al., 2019)

Ras85D|scrib

suppressible

Mmp2

(Uhlirova and Bohmann, 2006)

Ras85D|scrib

suppressible

Mmp1|Mmp2

(Uhlirova and Bohmann, 2006)

Snr1

suppressible

Mmp2

(Tegeder et al., 2019)

Sox21a

suppressible

Mmp2

(Zhai et al., 2015)

Timp

suppressible

Mmp2

(Wang et al., 2010)

trol

suppressible

Mmp2

(Bonche et al., 2022)

TyrRS

suppressible

Mmp2

(Casas-Tintó et al., 2015)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61828

DroID - A comprehensive database of gene and protein interactions.

FBgn0033438

MIST (genetic) - An integrated Molecular Interaction Database

35997

MIST (protein-protein) - An integrated Molecular Interaction Database

35997

Pathways

Signaling Pathways (FlyBase)

NEGATIVE REGULATORS OF FGFR SIGNALING PATHWAY
NEGATIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-61

Cytogenetic map

45F6-46A1

Sequence location

2R:9,611,139..9,683,858 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

45F6-46A1

Limits computationally determined from genome sequence between P{lacW}l(2)k09501^k09501 and P{PZ}Mmp2⁰²³⁵³&P{PZ}Uba1⁰⁵⁶⁴²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

46A1-46A2

(determined by in situ hybridisation)

(Spradling et al., 1999)

46A1-46A2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-61

(FlyBase, 2016)

2-59.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (55)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Korea

12345

P{VT014200-GAL4}attP2

13092

P{VT014202-GAL4}attP2

13093

P{VT014211-GAL4}attP2

15060

P{VT014206-GAL4}attP2

15061

P{VT014210-GAL4}attP2

14573

P{VT014200-lexA}attP2

14583

P{VT014208-lexA}attP40

1794-1R-1

1794-1R-2

v330203

v107888

v200337

P{VT014208-GAL4}attP2

More stocks available...

Genomic Clones (43)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (43)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD03462

Other clones

FI21212

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0033438

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0033438

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Palmer et al., 2024, Dear et al., 2016, Jia et al., 2014, Wang et al., 2010)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Mmp2 limits long-distance wg signaling in the germarium. Mmp2 protein cleaves dlp protein in cultured cells and is expressed in the apical cells (and a few anterior escort cells) of the germarium niche. Mmp2 may act to limit wg signaling in the the germarium by cleaving dlp protein near the wg source, resulting in relocation of dlp protein from the cell surface to intracellular vesicles, such that dlp can no longer contact wg protein and promote long-range wg signaling.

(Wang and Page-McCaw, 2014)

Putative substrate for the kinase png.

(Lee et al., 2005)

Mutants are pupal lethal and show defects in oogenesis.

(Page-McCaw et al., 2002)

Area matching Drosophila EST AI238523.

(Davies, 2001.3.15)

Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

(Roch et al., 1998)

Relationship to Other Genes

Source for database merge of

Source for merge of: l(2)02353 Mmp2

(Page-McCaw et al., 2003)

Source for merge of: Mmp2 anon-WO0118547.84

(FlyBase, 1996-)

Additional comments

Source for merge of Mmp2 anon-WO0118547.84 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Mmp2 CG1794

(Page-McCaw, 2002.3.18)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

2-MMP

(Santamaria, 2000.5.25)

CG1794

(National Institute of Genetics Fly Stocks, 2022-, Meadows, 2017.1.11, Palu and Thummel, 2016, Chen et al., 2012, Aerts et al., 2010, Lunardi et al., 2010, Zhang et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Macdonald and Long, 2006, Ostrin et al., 2006, Huet et al., 2002, Coates et al., 2000)

Dm2-MMP

(Miller et al., 2010, Llano et al., 2002)

MMP2

(Hounsell and Fan, 2025, Bilder et al., 2021, Hounsell and Fan, 2021, Mickael et al., 2021, Soans and Norden, 2021, Hughes et al., 2020, Portela et al., 2020, Walls et al., 2020, Sui et al., 2018, Hughes and Jacobs, 2017, Wang et al., 2017, Ordan and Volk, 2016, Zheng et al., 2016, Shen et al., 2014, Das and Cagan, 2013, Meyer et al., 2011, Miles et al., 2011, Curtin et al., 2007, Vidal et al., 2006)

Matrix metalloproteinase 2

(Jin et al., 2016)

Mmp2

(Mendoza Andrade et al., 2025, Berg et al., 2024, Kwon et al., 2024, Li et al., 2024, Miao et al., 2024, Pignataro et al., 2024, Rui, 2024, Walther et al., 2024, Zeng et al., 2024, Bossen et al., 2023, Liu et al., 2023, Olivares et al., 2023, Xu et al., 2023, Yamada et al., 2023, Crucianelli et al., 2022, Pang et al., 2022, Waghmare and Page-McCaw, 2022, White and Wolfner, 2022, Hoshino and Niwa, 2021, Joy et al., 2021, Lodge et al., 2021, Su et al., 2021, Sun et al., 2021, Wei et al., 2021, White et al., 2021, Diaz-de-la-Loza et al., 2020, Jevitt et al., 2020, Krautz et al., 2020, Parra and Johnston, 2020, Pastor-Pareja, 2020, Rushton et al., 2020, Statzer and Ewald, 2020, Zhou and Boutros, 2020, Brunet Avalos et al., 2019, Kanda et al., 2019, Kockel et al., 2019, Meltzer et al., 2019, Ramos-Lewis and Page-McCaw, 2019, Swevers, 2019, Tegeder et al., 2019, Wittes and Schüpbach, 2019, Yang and Chien, 2019, Yang et al., 2019, Ariss et al., 2018, Cho et al., 2018, Gene Disruption Project members, 2018-, Li et al., 2018, Richardson and Portela, 2018, Tsai et al., 2018, Wu et al., 2018, Cannon et al., 2017, Fochler et al., 2017, Garlapow et al., 2017, Jia et al., 2017, Kline et al., 2017, LaFever et al., 2017, Purice et al., 2017, Clandinin and Owens, 2016-, Jin et al., 2016, Pearson et al., 2016, Small and Crawford, 2016, Casas-Tintó et al., 2015, Deady and Sun, 2015, Deady et al., 2015, Duff et al., 2015, Gene Disruption Project members, 2015-, Schleede and Blair, 2015, Zhai et al., 2015, Ashwal-Fluss et al., 2014, Bonnay et al., 2014, Depetris-Chauvin et al., 2014, Jia et al., 2014, Kim and Choe, 2014, Schinaman et al., 2014, Wang and Page-McCaw, 2014, Muha and Müller, 2013, Sen et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Nfonsam et al., 2012, Stevens and Page-McCaw, 2012, Sui et al., 2012, Miller et al., 2011, Schmidt et al., 2011, Xie and Auld, 2011, Aerts et al., 2010, Wang et al., 2010, Yasunaga et al., 2010, Glasheen et al., 2009, Guha et al., 2009, Shen et al., 2009, Gilchrist et al., 2008, McClure et al., 2008, Miller et al., 2008, Dominguez-Gimenez et al., 2007, Srivastava et al., 2007, Macdonald and Long, 2006, Meyer and Aberle, 2006, Ostrin et al., 2006, Curtin et al., 2005, Lee et al., 2005)

SN2-2

(Gavory et al., 2021)

anon-WO0118547.84

dMMP2

(Hearst et al., 2021, Yang et al., 2017)

dm-2MMP

(Wei et al., 2003)

dmmp2

(Singh et al., 2010, Vidal et al., 2010)

l(2)02353

(Page-McCaw et al., 2003, Spradling et al., 1999, Roch et al., 1998, BDGP Project Members, 1994-1999)

Name Synonyms

Matrix Metalloprotinase 2

(Rudrapatna et al., 2014)

Matrix metalloproteinase

(Macdonald and Long, 2006)

Matrix metalloproteinase 2

(Ramond et al., 2020, Ordan and Volk, 2016, Shen et al., 2009, Page-McCaw et al., 2002)

Mmp2

(Rapti, 2023)

Suppressor of NA9 2-2

(Gavory et al., 2021)

matrix metalloprotease 2

(Wang et al., 2010)

matrix metalloproteinase

(Schmidt et al., 2011)

matrix metalloproteinase 2

(Zhai et al., 2015)

matrix metalloproteinase-2

(Jain et al., 2018)

Secondary FlyBase IDs

FBgn0010512
FBgn0061593

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 78 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35997

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8MPP3

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q8MPP3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8MPP3

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35997/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033438

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033438

FlyMine - An integrated database for Drosophila genomics

FBgn0033438

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1794

MARRVEL_MODEL - MARRVEL (model organism gene)

35997

Linkouts

BioGRID - A database of protein and genetic interactions.

61828

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0033438

DroID - A comprehensive database of gene and protein interactions.

FBgn0033438

DRSC - Results frm RNAi screens

FBgn0033438

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033438

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0033438

Flygut - An atlas of the Drosophila adult midgut

FBgn0033438

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0033438

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006735

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

35997

MIST (protein-protein) - An integrated Molecular Interaction Database

35997

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (253)

The following external sites may use different assemblies or annotations than FlyBase.

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