FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\dock
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General Information
Symbol
Dmel\dock
Species
D. melanogaster
Name
dreadlocks
Annotation Symbol
CG3727
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010583
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
Adapter protein that links cell surface receptor tyrosine phosphorylation to downstream signaling pathways and effectors, many of which are involved in regulation of the actin cytoskeleton (PubMed:8646773). Recruited by Dscam1/Down syndrome cell adhesion molecule homolog and InR/insulin-like receptor (PubMed:10892653, PubMed:12702880). Recruits Pak to membranes, probably when dock/dreadlocks is associated with activated receptors (PubMed:10399914). Required for guidance and targeting of photoreceptor (R cell) axon projections but not for axon outgrowth, differentiation or target induction in the developing eye (PubMed:10399914, PubMed:12702880, PubMed:8646773, PubMed:9482841). As part of a signaling pathway that involves the lbm/late bloomer protein, involved in synapse formation of the RP3 motorneuron at the muscle 7/6 cleft, probably by stimulating axon defasciculation from other SNb neurons (PubMed:10068645). (UniProt, Q8IPW2)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Nck

Key Links
Genomic Location
Cytogenetic map
21E2-21E2
Sequence location
Recombination map
2-1.5
RefSeq locus
NT_033779 REGION:825969..833241
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
enables cell adhesion molecule binding
inferred from physical interaction with FLYBASE:rst; FB:FBgn0003285
(Kaipa et al., 2013)
inferred from physical interaction with FLYBASE:sns; FB:FBgn0024189
(Kaipa et al., 2013)
inferred from physical interaction with FLYBASE:kirre; FB:FBgn0028369
(Kaipa et al., 2013)
inferred from physical interaction with FLYBASE:hbs; FB:FBgn0287864
(Kaipa et al., 2013)
enables insulin receptor binding
inferred from physical interaction with FLYBASE:InR; FB:FBgn0283499
(Song et al., 2003)
enables kinase binding
inferred from physical interaction with UniProtKB:Q9VZI2
(Abdallah et al., 2013, Worby et al., 2002)
enables protein binding
inferred from physical interaction with FLYBASE:ckn; FB:FBgn0033987
(Weng et al., 2011)
inferred from physical interaction with UniProtKB:Q9NCC3
(Worby et al., 2002)
enables protein kinase binding
inferred from physical interaction with FLYBASE:Pak; FB:FBgn0267698
(Hing et al., 1999)
enables protein-macromolecule adaptor activity
inferred from physical interaction with FLYBASE:Ptp61F; FB:FBgn0267487,FLYBASE:InR; FB:FBgn0283499
(Wu et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Weng et al., 2011, Stevens and Jacobs, 2002)
inferred from genetic interaction with FLYBASE:Dscam1; FB:FBgn0033159
(Schmucker et al., 2000)
involved_in myoblast fusion
inferred from genetic interaction with FLYBASE:sns; FB:FBgn0024189
(Kaipa et al., 2013)
inferred from genetic interaction with FLYBASE:kirre; FB:FBgn0028369
(Kaipa et al., 2013)
inferred from genetic interaction with FLYBASE:hbs; FB:FBgn0287864
(Kaipa et al., 2013)
involved_in negative regulation of insulin receptor signaling pathway
inferred from genetic interaction with FLYBASE:Ptp61F; FB:FBgn0267487
(Willoughby et al., 2017)
inferred from genetic interaction with FLYBASE:Ptp61F; FB:FBgn0267487,FLYBASE:InR; FB:FBgn0283499
(Wu et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cell periphery
inferred from direct assay
(Abdallah et al., 2013)
located_in clathrin-coated vesicle
inferred from direct assay
(Abdallah et al., 2013)
located_in male germline ring canal
inferred from direct assay
(Abdallah et al., 2013)
located_in nuclear body
inferred from direct assay
(Abdallah et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in cytosol
non-traceable author statement
(Dickson, 2003)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Pathway (FlyBase)
NEGATIVE REGULATORS OF INSULIN-LIKE RECEPTOR SIGNALING PATHWAY -
Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
Protein Function (UniProtKB)
Adapter protein that links cell surface receptor tyrosine phosphorylation to downstream signaling pathways and effectors, many of which are involved in regulation of the actin cytoskeleton (PubMed:8646773). Recruited by Dscam1/Down syndrome cell adhesion molecule homolog and InR/insulin-like receptor (PubMed:10892653, PubMed:12702880). Recruits Pak to membranes, probably when dock/dreadlocks is associated with activated receptors (PubMed:10399914). Required for guidance and targeting of photoreceptor (R cell) axon projections but not for axon outgrowth, differentiation or target induction in the developing eye (PubMed:10399914, PubMed:12702880, PubMed:8646773, PubMed:9482841). As part of a signaling pathway that involves the lbm/late bloomer protein, involved in synapse formation of the RP3 motorneuron at the muscle 7/6 cleft, probably by stimulating axon defasciculation from other SNb neurons (PubMed:10068645).
(UniProt, Q8IPW2)
Summary (Interactive Fly)

SH2 and SH3 domain signal transduction protein - required for photoreceptor cell growth cone guidance and targeting

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\dock for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8IPW2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
dock-RA
FBtr0078013
NM_057628
3735
410
dock-RB
FBtr0078014
NM_164389
3618
548
dock-RC
FBtr0078015
NM_164390
3583
548
dock-RD
FBtr0332973
NM_001272916
2825
548
Additional Transcript Data and Comments
Reported size (kB)

4.1, 3.7 (northern blot)

(Clemens et al., 1996)

3.760 (longest cDNA)

(Garrity et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
dock-PA
FBpp0077678
45.7
410
8.39
Q8IPW2
NP_476976
AAF51450
dock-PB
FBpp0077679
60.4
548
8.71
Q8IPW2
NP_722657
AAF51449
dock-PC
FBpp0077680
60.4
548
8.71
Q8IPW2
NP_722658
AAN10486
dock-PD
FBpp0305189
60.4
548
8.71
Q8IPW2
NP_001259845
AGB92382
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

548 aa isoforms: dock-PB, dock-PC, dock-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

410 (aa); 50 (kD observed)

(Clemens et al., 1996)

410 (aa); 47 (kD observed)

(Garrity et al., 1996)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts (via SH2 and SH3 domains) with Dscam1 (via cytoplasmic domain); the interaction is direct and requires Dscam1 to be phosphorylated (PubMed:10892653). Interacts (via SH2 and SH3 domains) with InR/Insulin-like receptor (via C-terminal cytoplasmic region); the interaction requires InR kinase activity, probably for autophosphorylation stimulated by insulin signaling (PubMed:12702880). Interacts with Ptp61F (via C-terminus); this interaction is independent of insulin stimulation (PubMed:21707536, PubMed:8663600). Interacts (via SH3 domain 2) with Pak (via N-terminal PXXP motif) (PubMed:10399914).

(UniProt, Q8IPW2)
Post Translational Modification

Phosphorylated by Src42A and possibly by other tyrosine kinases (PubMed:12014990). Constitutively dephosphorylated by its binding partner Ptp61F (PubMed:12014990).

(UniProt, Q8IPW2)
Domain

Possesses 3 SH3 domains, which bind polyproline motifs, and 1 SH2 domain that binds phosphotyrosine (PubMed:8646773). The SH2 and SH3 domains are cooperatively involved in the binding of the cytoplasmic domains of Dscam1 and InR (PubMed:10892653, PubMed:12702880). SH3 domain 1 preferentially binds Dscam1 PXXP motif 1 (PubMed:10892653). SH3 domain 2 preferentially binds Dscam1 polyproline tract (PubMed:10892653). SH3 domain 3 preferentially binds Dscam1 PXXP motif 2 (PubMed:10892653). Interaction of the SH2 domain with Dscam1 requires Dscam1 to be phosphorylated (PubMed:10892653). InR can interact with either the SH3 domains (all 3 domains required) or the SH2 domain (PubMed:12702880). Only SH3 domain 2 binding activity is essential, but not sufficient, for R cell projection targeting (PubMed:9482841). SH3 domain 1, SH3 domain 2 and the SH2 binding activities contribute to R cell targeting but have redundant functions (PubMed:9482841). SH3 domain 2 and the SH2 domain are both essential for targeting and patterning of inner optic ganglion neurons (PubMed:9482841). SH3 domain 2 is necessary and sufficient for binding to Pak (PubMed:10399914).

(UniProt, Q8IPW2)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dock using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.61

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & pupal stage & adult stage
(Clemens et al., 1996)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 14
embryonic brain
(Clemens et al., 1996)
larval ventral nerve cord
(Clemens et al., 1996)
embryonic stage 15
ventral nerve cord
(Magalhaes et al., 2007)
embryonic brain | restricted
(Magalhaes et al., 2007)
larval stage
embryonic/larval garland cell
(Tutor et al., 2014)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & pupal stage & adult stage
(Clemens et al., 1996)
Additional Descriptive Data

dock transcripts are detected in the brain and ventral nerve cord of stage 14 embryos. Ptp61F and dock transcripts are expressed in a similar pattern throughout development, with high levels in embryonic, pupal and adult stages.

(Clemens et al., 1996)

dock transcripts are detected at high levels in embryonic, pupal and adult stages.

(Clemens et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 14
somatic trunk mesoderm
(Kaipa et al., 2013)
muscle founder cell
(Kaipa et al., 2013)
fusion competent cell
(Kaipa et al., 2013)
muscle attachment site
(Kaipa et al., 2013)
third instar larval stage
neuron
(Garrity et al., 1996)
eye-antennal disc
(Garrity et al., 1996)
lamina anlage
(Garrity et al., 1996)
medulla anlage
(Garrity et al., 1996)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

dock protein is expressed in receptor cells and localizes to receptor cell growth cones. It is also observed in the lamina and medulla neuropil.

(Garrity et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cell periphery
inferred from direct assay
(Abdallah et al., 2013)
located_in clathrin-coated vesicle
inferred from direct assay
(Abdallah et al., 2013)
located_in male germline ring canal
inferred from direct assay
(Abdallah et al., 2013)
located_in nuclear body
inferred from direct assay
(Abdallah et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dock in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 19 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 40 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dock
Transgenic constructs containing regulatory region of dock
Aberrations (Deficiencies and Duplications) ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | embryonic stage | maternal effect | recessive
lethal | pupal stage | recessive
lethal | recessive
lethal - all die before end of pupal stage | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal neuroanatomy
abnormal neuroanatomy | cell non-autonomous | somatic clone
abnormal neuroanatomy | embryonic stage
abnormal neuroanatomy | embryonic stage, with Scer\GAL4eve.RN2
abnormal neuroanatomy | embryonic stage (with dock3)
abnormal neuroanatomy | embryonic stage (with dock13421)
abnormal neuroanatomy | embryonic stage | recessive
abnormal neuroanatomy | larval stage, with Scer\GAL4P2.4.Pdf
abnormal neuroanatomy | pupal stage
abnormal neuroanatomy | somatic clone
abnormal neurophysiology | adult stage
abnormal size | oogenesis, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG, dock04723
abnormal size | oogenesis, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG, dockGL01519
decreased fecundity, with Scer\GAL4VP16.mat.αTub67C
decreased size, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
decreased size | germline clone | oogenesis
decreased size | germline clone | oogenesis | semidominant
decreased size | maternal effect
decreased size | maternal effect, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
decreased size | maternal effect, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG, dock04723
decreased size | maternal effect, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG, dockGL01519
increased cell number | somatic clone, with Scer\GAL4wor.PA
majority die during embryonic stage | maternal effect, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
short lived
some die during embryonic stage | maternal effect, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG, dock04723
some die during embryonic stage | maternal effect, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG, dockGL01519
some die during pupal stage | recessive
uncoordinated | recessive
visible, with Scer\GAL4GMR.PF
wild-type
Phenotype manifest in
Allele
adult antennal nerve | P-stage
antennal lobe
antennal lobe & neuropil
antennal lobe | cell non-autonomous | somatic clone
antennal lobe glomerulus | P-stage | ectopic
antennal lobe glomerulus DM2
antennal lobe glomerulus DM3
Bolwig nerve
Bolwig nerve (with Df(2R)EW60)
Bolwig nerve (with dock04723)
Bolwig nerve (with dock13421)
dendrite | embryonic stage
dendrite | embryonic stage, with Scer\GAL4eve.RN2
egg | absent, with Scer\GAL4VP16.mat.αTub67C
egg | maternal effect
egg | maternal effect, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
egg | maternal effect, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG, dock04723
egg | maternal effect, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG, dockGL01519
egg chamber, with Scer\GAL4VP16.mat.αTub67C
embryonic/larval optic lobe
embryonic/larval optic lobe | somatic clone
embryonic/larval optic stalk
eye, with Scer\GAL4GMR.PF
eye photoreceptor cell & growth cone
glial cell & antennal lobe
lamina
lamina anlage
lamina plexus
larval DA1 motor neuron | embryonic stage
larval DA1 motor neuron | embryonic stage, with Scer\GAL4eve.RN2
larval inner optic anlage
larval longitudinal connective
larval longitudinal connective | maternal effect
larval MP1 neuron
larval outer optic anlage
larval s-LNv neuron, with Scer\GAL4P2.4.Pdf
larval somatic muscle cell
larval ventral nerve cord commissure
larval VL3/4 motor neuron | embryonic stage
larval VUM neuron
lobula
medulla
medulla | somatic clone
medulla anlage
neuroblast | increased number | somatic clone, with Scer\GAL4wor.PA
neuromuscular junction | embryonic stage
neuron & antennal lobe
neuron | somatic clone
neuron projection | larval stage, with Scer\GAL4P2.4.Pdf
nurse cell ring canal, with Scer\GAL4VP16.mat.αTub67C
nurse cell ring canal, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
nurse cell ring canal, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG, dock04723
nurse cell ring canal, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG, dockGL01519
nurse cell ring canal | decreased number, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
nurse cell ring canal | germline clone
pCC neuron
photoreceptor & axon
photoreceptor & axon | somatic clone
photoreceptor cell & axon
photoreceptor cell & axon (with dock4)
photoreceptor cell & axon (with dock04723)
photoreceptor cell & axon | somatic clone
photoreceptor cell R1
photoreceptor cell R1 & axon
photoreceptor cell R2
photoreceptor cell R2 & axon
photoreceptor cell R3
photoreceptor cell R3 & axon
photoreceptor cell R4
photoreceptor cell R4 & axon
photoreceptor cell R5
photoreceptor cell R5 & axon
photoreceptor cell R6
photoreceptor cell R6 & axon
photoreceptor cell R7
photoreceptor cell R7 & axon
photoreceptor cell R7 & axon | somatic clone
photoreceptor cell R8
photoreceptor neuron | somatic clone
RP3 neuron & synapse
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (93)
Hsap\NCK1
14 of 14
Yes
Yes
 
2  
Hsap\NCK2
13 of 14
No
Yes
Hsap\GRAP2
2 of 14
No
No
Hsap\GRAP
2 of 14
No
No
2  
Hsap\GRAPL
2 of 14
No
No
Hsap\SLA2
2 of 14
No
Yes
Hsap\ABL1
1 of 14
No
No
0  
Hsap\ABL2
1 of 14
No
No
2  
Hsap\ARHGAP25
1 of 14
No
No
Hsap\BCAR3
1 of 14
No
No
1  
Hsap\BLK
1 of 14
No
No
Hsap\BTK
1 of 14
No
No
3  
Hsap\CD2AP
1 of 14
No
No
5  
Hsap\CHN2
1 of 14
No
No
Hsap\CRK
1 of 14
No
No
1  
Hsap\CRKL
1 of 14
No
No
2  
Hsap\CSK
1 of 14
No
No
1  
Hsap\CYTH1
1 of 14
No
No
1  
Hsap\DAPP1
1 of 14
No
Yes
Hsap\DNMBP
1 of 14
No
No
Hsap\EPS8
1 of 14
No
No
Hsap\FCHSD2
1 of 14
No
No
Hsap\FER
1 of 14
No
No
1  
Hsap\FGR
1 of 14
No
No
1  
Hsap\FRK
1 of 14
No
No
Hsap\FYN
1 of 14
No
No
3  
Hsap\GRB2
1 of 14
No
No
Hsap\GRB7
1 of 14
No
No
Hsap\GRB10
1 of 14
No
No
Hsap\GRB14
1 of 14
No
No
Hsap\HCK
1 of 14
No
No
Hsap\INPP5D
1 of 14
No
No
1  
Hsap\INPPL1
1 of 14
No
No
Hsap\ITK
1 of 14
No
No
1  
Hsap\ITSN1
1 of 14
No
No
Hsap\ITSN2
1 of 14
No
No
1  
Hsap\LCK
1 of 14
No
No
Hsap\LCP2
1 of 14
No
No
Hsap\LYN
1 of 14
No
No
Hsap\MATK
1 of 14
No
No
1  
Hsap\NCF1B
1 of 14
No
Yes
Hsap\NCF1C
1 of 14
No
Yes
Hsap\NCF1
1 of 14
No
Yes
Hsap\NOXO1
1 of 14
No
Yes
Hsap\PIK3R1
1 of 14
No
No
Hsap\PIK3R2
1 of 14
No
No
Hsap\PIK3R3
1 of 14
No
No
Hsap\PLCG1
1 of 14
No
No
8  
Hsap\PLCG2
1 of 14
No
No
2  
Hsap\PLEKHA1
1 of 14
No
Yes
Hsap\PTK6
1 of 14
No
No
Hsap\PTPN6
1 of 14
No
No
3  
Hsap\PTPN11
1 of 14
No
No
7  
Hsap\RASA1
1 of 14
No
No
Hsap\RIMBP2
1 of 14
No
No
Hsap\RIMBP3B
1 of 14
No
No
Hsap\RIMBP3C
1 of 14
No
No
Hsap\RIMBP3
1 of 14
No
No
Hsap\SH2B3
1 of 14
No
No
Hsap\SH2D1A
1 of 14
No
No
Hsap\SH2D1B
1 of 14
No
No
1  
Hsap\SH2D4B
1 of 14
No
Yes
Hsap\SH2D5
1 of 14
No
No
Hsap\SH2D7
1 of 14
No
Yes
Hsap\SH3D19
1 of 14
No
No
Hsap\SH3GL3
1 of 14
No
No
Hsap\SH3KBP1
1 of 14
No
No
1  
Hsap\SH3PXD2A
1 of 14
No
Yes
Hsap\SH3PXD2B
1 of 14
No
Yes
Hsap\SH3RF1
1 of 14
No
No
Hsap\SH3RF3
1 of 14
No
No
Hsap\SHB
1 of 14
No
No
Hsap\SHC1
1 of 14
No
No
1  
Hsap\SHC3
1 of 14
No
No
Hsap\SHC4
1 of 14
No
No
1  
Hsap\SHD
1 of 14
No
No
Hsap\SHE
1 of 14
No
No
Hsap\SHF
1 of 14
No
No
Hsap\SLA
1 of 14
No
Yes
Hsap\SORBS1
1 of 14
No
No
Hsap\SORBS2
1 of 14
No
No
Hsap\SORBS3
1 of 14
No
No
1  
Hsap\SPTAN1
1 of 14
No
No
Hsap\SRC
1 of 14
No
No
Hsap\SRMS
1 of 14
No
No
Hsap\SYK
1 of 14
No
No
Hsap\TEC
1 of 14
No
No
Hsap\TSPOAP1
1 of 14
No
No
Hsap\TXK
1 of 14
No
No
Hsap\VAV1
1 of 14
No
No
1  
Hsap\VAV2
1 of 14
No
No
Hsap\VAV3
1 of 14
No
No
Hsap\YES1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (63)
Rnor\Nck2
13 of 14
Yes
Yes
Rnor\Nck1
12 of 14
No
Yes
Rnor\Grap
2 of 14
No
No
Rnor\Abl1
1 of 14
No
No
Rnor\Abl2
1 of 14
No
No
Rnor\Bcar3
1 of 14
No
No
Rnor\Crkl
1 of 14
No
No
Rnor\Crk
1 of 14
No
No
Rnor\Csk
1 of 14
No
No
Rnor\Dapp1
1 of 14
No
Yes
Rnor\Dnmbp
1 of 14
No
No
Rnor\Fgr
1 of 14
No
No
Rnor\Frk
1 of 14
No
No
Rnor\Fyn
1 of 14
No
No
Rnor\Grb2
1 of 14
No
No
Rnor\Grb10
1 of 14
No
No
Rnor\Grb14
1 of 14
No
No
Rnor\Hck
1 of 14
No
No
Rnor\Inpp5d
1 of 14
No
No
Rnor\Inppl1
1 of 14
No
No
Rnor\Itk
1 of 14
No
No
Rnor\Itsn1
1 of 14
No
No
Rnor\Itsn2
1 of 14
No
No
Rnor\Lck
1 of 14
No
No
Rnor\Ncf1
1 of 14
No
Yes
Rnor\Noxo1
1 of 14
No
Yes
Rnor\Pik3r2
1 of 14
No
No
Rnor\Plcg1
1 of 14
No
No
Rnor\Plcg2
1 of 14
No
No
Rnor\Plekha1
1 of 14
No
Yes
Rnor\Prmt2
1 of 14
No
No
Rnor\Ptpn6
1 of 14
No
No
Rnor\Ptpn11
1 of 14
No
No
Rnor\Rasa1
1 of 14
No
No
Rnor\Rimbp2
1 of 14
No
No
Rnor\Rimbp3
1 of 14
No
No
Rnor\Sh2d1a
1 of 14
No
No
Rnor\Sh2d1b2
1 of 14
No
No
Rnor\Sh2d1b
1 of 14
No
No
Rnor\Sh2d5
1 of 14
No
No
Rnor\Sh3d19
1 of 14
No
No
Rnor\Sh3pxd2a
1 of 14
No
Yes
Rnor\Sh3rf3
1 of 14
No
No
Rnor\Shb
1 of 14
No
No
Rnor\Shc1
1 of 14
No
No
Rnor\Shc2
1 of 14
No
No
Rnor\Shc3
1 of 14
No
No
Rnor\Shc4
1 of 14
No
No
Rnor\Shd
1 of 14
No
No
Rnor\She
1 of 14
No
No
Rnor\Shf
1 of 14
No
Yes
Rnor\Sla2
1 of 14
No
Yes
Rnor\Sla
1 of 14
No
Yes
Rnor\Sorbs2
1 of 14
No
No
Rnor\Sorbs3
1 of 14
No
No
Rnor\Src
1 of 14
No
No
Rnor\Srms
1 of 14
No
No
Rnor\Syk
1 of 14
No
No
Rnor\Tspoap1
1 of 14
No
No
Rnor\Txk
1 of 14
No
No
Rnor\Vav1
1 of 14
No
No
Rnor\Vav3
1 of 14
No
No
Rnor\Yes1
1 of 14
No
No
Mus musculus (laboratory mouse) (64)
Mmus\Nck1
14 of 14
Yes
Yes
Mmus\Nck2
12 of 14
No
Yes
Mmus\Grap
2 of 14
No
No
Mmus\Abl1
1 of 14
No
No
Mmus\Abl2
1 of 14
No
No
Mmus\Bcar3
1 of 14
No
No
Mmus\Crkl
1 of 14
No
No
Mmus\Crk
1 of 14
No
No
Mmus\Csk
1 of 14
No
No
Mmus\Dapp1
1 of 14
No
Yes
Mmus\Dnmbp
1 of 14
No
Yes
Mmus\Fgr
1 of 14
No
No
Mmus\Frk
1 of 14
No
No
Mmus\Fyn
1 of 14
No
No
Mmus\Grap2
1 of 14
No
No
Mmus\Grb2
1 of 14
No
No
Mmus\Grb10
1 of 14
No
No
Mmus\Hck
1 of 14
No
No
Mmus\Inpp5d
1 of 14
No
No
Mmus\Inppl1
1 of 14
No
No
Mmus\Itk
1 of 14
No
No
Mmus\Itsn1
1 of 14
No
No
Mmus\Itsn2
1 of 14
No
No
Mmus\Lck
1 of 14
No
No
Mmus\Ncf1
1 of 14
No
Yes
Mmus\Noxo1
1 of 14
No
Yes
Mmus\Pik3r2
1 of 14
No
No
Mmus\Plcg1
1 of 14
No
No
Mmus\Plcg2
1 of 14
No
No
Mmus\Plekha1
1 of 14
No
Yes
Mmus\Prmt2
1 of 14
No
No
Mmus\Ptpn6
1 of 14
No
No
Mmus\Ptpn11
1 of 14
No
No
Mmus\Rasa1
1 of 14
No
No
Mmus\Rimbp2
1 of 14
No
No
Mmus\Rimbp3
1 of 14
No
No
Mmus\Sh2d1a
1 of 14
No
No
Mmus\Sh2d1b1
1 of 14
No
Yes
Mmus\Sh2d1b2
1 of 14
No
No
Mmus\Sh2d5
1 of 14
No
Yes
Mmus\Sh3d19
1 of 14
No
No
Mmus\Sh3pxd2a
1 of 14
No
Yes
Mmus\Sh3pxd2b
1 of 14
No
Yes
Mmus\Sh3rf3
1 of 14
No
No
Mmus\Shb
1 of 14
No
No
Mmus\Shc1
1 of 14
No
No
Mmus\Shc2
1 of 14
No
No
Mmus\Shc3
1 of 14
No
No
Mmus\Shc4
1 of 14
No
No
Mmus\Shd
1 of 14
No
No
Mmus\She
1 of 14
No
No
Mmus\Shf
1 of 14
No
No
Mmus\Sla2
1 of 14
No
Yes
Mmus\Sla
1 of 14
No
Yes
Mmus\Sorbs1
1 of 14
No
No
Mmus\Sorbs2
1 of 14
No
No
Mmus\Sorbs3
1 of 14
No
No
Mmus\Src
1 of 14
No
No
Mmus\Syk
1 of 14
No
No
Mmus\Tspoap1
1 of 14
No
No
Mmus\Txk
1 of 14
No
No
Mmus\Vav1
1 of 14
No
No
Mmus\Vav3
1 of 14
No
No
Mmus\Yes1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (52)
Xtro\nck1
11 of 13
Yes
Yes
Xtro\nck2
6 of 13
No
Yes
Xtro\abl1
1 of 13
No
No
Xtro\abl2
1 of 13
No
No
Xtro\acap3
1 of 13
No
No
Xtro\bcar3
1 of 13
No
No
Xtro\btk
1 of 13
No
No
Xtro\chn2
1 of 13
No
No
Xtro\crkl
1 of 13
No
No
Xtro\csk
1 of 13
No
No
Xtro\dapp1
1 of 13
No
Yes
Xtro\dgkk
1 of 13
No
No
Xtro\eps8l2
1 of 13
No
No
Xtro\fchsd1
1 of 13
No
No
Xtro\fchsd2
1 of 13
No
No
Xtro\fer
1 of 13
No
No
Xtro\fgf22
1 of 13
No
No
Xtro\frk
1 of 13
No
No
Xtro\gm2a
1 of 13
No
No
Xtro\grap
1 of 13
No
No
Xtro\grb2
1 of 13
No
No
Xtro\grb7
1 of 13
No
Yes
Xtro\itsn2
1 of 13
No
No
Xtro\lck
1 of 13
No
No
Xtro\LOC101733866
1 of 13
No
Yes
Xtro\lrit2
1 of 13
No
No
Xtro\ncf1
1 of 13
No
Yes
Xtro\noxo1.1
1 of 13
No
Yes
Xtro\pik3r1
1 of 13
No
No
Xtro\pik3r2
1 of 13
No
No
Xtro\pik3r3
1 of 13
No
No
Xtro\plekha1
1 of 13
No
Yes
Xtro\ptk6
1 of 13
No
No
Xtro\ptpn11b
1 of 13
No
No
Xtro\ptpn11
1 of 13
No
No
Xtro\rasa1
1 of 13
No
No
Xtro\sfrpx
1 of 13
No
No
Xtro\sh2d1a
1 of 13
No
Yes
Xtro\sh2d4b
1 of 13
No
Yes
Xtro\sh3kbp1
1 of 13
No
No
Xtro\shb
1 of 13
No
No
Xtro\shc2
1 of 13
No
No
Xtro\she
1 of 13
No
No
Xtro\shf
1 of 13
No
No
Xtro\sla2
1 of 13
No
Yes
Xtro\stac3
1 of 13
No
No
Xtro\t2r21
1 of 13
No
Yes
Xtro\tas2r39
1 of 13
No
No
Xtro\tepsin
1 of 13
No
No
Xtro\uqcrfs1
1 of 13
No
No
Xtro\XB5826631
1 of 13
No
No
Xtro\zap70
1 of 13
No
No
Danio rerio (Zebrafish) (80)
Drer\nck1b
14 of 14
Yes
Yes
Drer\nck2a
13 of 14
No
Yes
Drer\nck2b
13 of 14
No
Yes
Drer\nck1a
12 of 14
No
Yes
Drer\grap2a
2 of 14
No
No
Drer\grap2b
2 of 14
No
No
Drer\grapa
2 of 14
No
No
Drer\grapb
2 of 14
No
No
Drer\abl1
1 of 14
No
No
Drer\abl2
1 of 14
No
No
Drer\acap1
1 of 14
No
No
Drer\bcar3
1 of 14
No
No
Drer\chn2
1 of 14
No
No
Drer\crk
1 of 14
No
No
Drer\crkl
1 of 14
No
No
Drer\csk
1 of 14
No
No
Drer\cyth1b
1 of 14
No
No
Drer\dapp1
1 of 14
No
Yes
Drer\dnmbp
1 of 14
No
No
Drer\frk
1 of 14
No
No
Drer\fyna
1 of 14
No
No
Drer\fynb
1 of 14
No
No
Drer\grb2a
1 of 14
No
No
Drer\grb2b
1 of 14
No
No
Drer\grb10b
1 of 14
No
No
Drer\grb14
1 of 14
No
Yes
Drer\inppl1a
1 of 14
No
No
Drer\inppl1b
1 of 14
No
No
Drer\itsn1
1 of 14
No
No
Drer\itsn2a
1 of 14
No
No
Drer\itsn2b
1 of 14
No
No
Drer\lck
1 of 14
No
No
Drer\LOC101884146
1 of 14
No
Yes
Drer\matk
1 of 14
No
No
Drer\ncf1
1 of 14
No
Yes
Drer\noxo1a
1 of 14
No
Yes
Drer\noxo1b
1 of 14
No
Yes
Drer\pik3r1
1 of 14
No
No
Drer\pik3r2
1 of 14
No
No
Drer\plcg1
1 of 14
No
No
Drer\plekha1a
1 of 14
No
Yes
Drer\plekha2
1 of 14
No
Yes
Drer\ptk6b
1 of 14
No
No
Drer\ptpn6
1 of 14
No
No
Drer\ptpn11a
1 of 14
No
No
Drer\ptpn11b
1 of 14
No
No
Drer\rasa1a
1 of 14
No
No
Drer\rasa1b
1 of 14
No
No
Drer\rimbp2a
1 of 14
No
No
Drer\rimbp2b
1 of 14
No
No
Drer\sh2d1aa
1 of 14
No
No
Drer\sh2d1ab
1 of 14
No
No
Drer\sh2d3a
1 of 14
No
No
Drer\sh3d19
1 of 14
No
No
Drer\sh3d21
1 of 14
No
No
Drer\sh3pxd2aa
1 of 14
No
Yes
Drer\sh3pxd2b
1 of 14
No
Yes
Drer\sh3rf2
1 of 14
No
No
Drer\shc1
1 of 14
No
No
Drer\shc2
1 of 14
No
No
Drer\shc3
1 of 14
No
No
Drer\shda
1 of 14
No
No
Drer\shdb
1 of 14
No
No
Drer\she
1 of 14
No
No
Drer\si:ch73-264p11.1
1 of 14
No
No
Drer\si:ch211-105f12.2
1 of 14
No
No
Drer\sla1a
1 of 14
No
Yes
Drer\sla2a
1 of 14
No
No
Drer\sla2b
1 of 14
No
Yes
Drer\sorbs1
1 of 14
No
No
Drer\sorbs2a
1 of 14
No
No
Drer\src
1 of 14
No
No
Drer\srgap1a
1 of 14
No
No
Drer\srgap1b
1 of 14
No
No
Drer\syk
1 of 14
No
No
Drer\vav2
1 of 14
No
No
Drer\vav3b
1 of 14
No
No
Drer\yes1
1 of 14
No
No
Drer\yrk
1 of 14
No
No
Drer\zgc:158464
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (15)
Cele\nck-1
12 of 14
Yes
Yes
Cele\abl-1
1 of 14
No
No
Cele\B0303.7
1 of 14
No
No
Cele\ced-2
1 of 14
No
No
Cele\chin-1
1 of 14
No
No
Cele\csk-1
1 of 14
No
No
Cele\itsn-1
1 of 14
No
No
Cele\plc-3
1 of 14
No
No
Cele\sem-5
1 of 14
No
No
Cele\sorb-1
1 of 14
No
No
Cele\spc-1
1 of 14
No
No
Cele\src-1
1 of 14
No
No
Cele\src-2
1 of 14
No
No
Cele\vav-1
1 of 14
No
No
Cele\Y37A1B.17
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (26)
Agam\AgaP_AGAP010135
12 of 12
Yes
Yes
Agam\AgaP_AGAP006774
2 of 12
No
No
Agam\AgaP_AGAP000864
1 of 12
No
No
Agam\AgaP_AGAP001148
1 of 12
No
No
Agam\AgaP_AGAP002438
1 of 12
No
No
Agam\AgaP_AGAP002729
1 of 12
No
No
Agam\AgaP_AGAP003735
1 of 12
No
No
Agam\AgaP_AGAP003986
1 of 12
No
No
Agam\AgaP_AGAP004211
1 of 12
No
No
Agam\AgaP_AGAP004989
1 of 12
No
No
Agam\AgaP_AGAP005258
1 of 12
No
Yes
Agam\AgaP_AGAP005616
1 of 12
No
No
Agam\AgaP_AGAP006270
1 of 12
No
No
Agam\AgaP_AGAP006510
1 of 12
No
No
Agam\AgaP_AGAP007717
1 of 12
No
No
Agam\AgaP_AGAP008317
1 of 12
No
No
Agam\AgaP_AGAP008737
1 of 12
No
No
Agam\AgaP_AGAP009037
1 of 12
No
No
Agam\AgaP_AGAP009499
1 of 12
No
No
Agam\AgaP_AGAP010710
1 of 12
No
No
Agam\AgaP_AGAP010886
1 of 12
No
No
Agam\AgaP_AGAP011151
1 of 12
No
No
Agam\AgaP_AGAP011152
1 of 12
No
No
Agam\AgaP_AGAP011463
1 of 12
No
No
Agam\AgaP_AGAP011768
1 of 12
No
No
Agam\AgaP_AGAP012240
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\BEM1
1 of 13
Yes
Yes
Scer\LSB1
1 of 13
Yes
No
Scer\PIN3
1 of 13
Yes
No
Scer\SHO1
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\shd1
1 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:dock. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (25)
Crk
2 of 13
drk
2 of 13
Src42A
2 of 13
Src64B
2 of 13
Abl
1 of 13
Btk
1 of 13
CAP
1 of 13
cindr
1 of 13
Csk
1 of 13
csw
1 of 13
Dap160
1 of 13
hwt
1 of 13
IPIP
1 of 13
metro
1 of 13
nwk
1 of 13
Pi3K21B
1 of 13
Rbp
1 of 13
Shark
1 of 13
Shc
1 of 13
sl
1 of 13
Socs36E
1 of 13
Stacl
1 of 13
Stam
1 of 13
step
1 of 13
vap
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
dockGD4034
ameliorates  amyotrophic lateral sclerosis type 8
modeled by Vap33P58S.UAS.Tag:FLAG
(Sanhueza et al., 2015)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
NCK1; NCK adaptor protein 1
14 of 14
600508
       
      NCK2; NCK adaptor protein 2
      13 of 14
      604930
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Dmel gene
          Ortholog showing functional complementation
          Supporting References
          dock
          Hsap\NCK1
          (Rao and Zipursky, 1998)
          Interactions
          Summary of Physical Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          dock
          two hybrid
          (Worby et al., 2002)
          dock - Ack
          anti bait coimmunoprecipitation, anti tag western blot, pull down, edman degradation, western blot, two hybrid
          (Abdallah et al., 2013, Worby et al., 2002)
          dock - Dscam1
          anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, edman degradation, autoradiography, western blot, anti bait coimmunoprecipitation, two hybrid, anti tag western blot, far western blotting
          (Liu et al., 2020, Yang et al., 2012, Huang et al., 2011, Worby et al., 2001, Schmucker et al., 2000)
          dock - Egfr
          two hybrid
          (Bianco et al., 2007)
          dock - InR
          two hybrid, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation
          (Li et al., 2014, Wu et al., 2011, Song et al., 2003)
          dock - Pak
          two hybrid, anti bait coimmunoprecipitation, western blot
          (Huang et al., 2011, Fan et al., 2003, Hing et al., 1999)
          dock - Ptp61F
          anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, enzymatic study, autoradiography, experimental knowledge based, two hybrid, pull down
          (Guruharsha et al., 2011, Wu et al., 2011, Muda et al., 2002, Clemens et al., 1996)
          dock - Pvr
          two hybrid
          (Bianco et al., 2007)
          dock - SCAR
          two hybrid
          (Kaipa et al., 2013)
          dock - SH3PX1
          pull down, western blot, anti bait coimmunoprecipitation, two hybrid, edman degradation
          (Worby et al., 2002, Worby et al., 2001)
          dock - Sos
          anti tag coimmunoprecipitation, anti tag western blot, two hybrid, pull down, western blot
          (Yang and Bashaw, 2006)
          dock - Src42A
          enzymatic study, autoradiography
          (Muda et al., 2002)
          dock - Vrp1
          two hybrid, anti tag coimmunoprecipitation, western blot
          (Kaipa et al., 2013)
          dock - WASp
          anti tag coimmunoprecipitation, anti tag western blot, two hybrid
          (Kaipa et al., 2013, Worby et al., 2001)
          dock - hbs
          anti tag coimmunoprecipitation, anti tag western blot, bimolecular fluorescence complementation, fluorescence microscopy
          (Kaipa et al., 2013)
          dock - kirre
          bimolecular fluorescence complementation, fluorescence microscopy, two hybrid, anti tag coimmunoprecipitation, anti tag western blot
          (Tutor et al., 2014, Kaipa et al., 2013)
          dock - msn
          two hybrid
          (Liu et al., 1999)
          dock - robo1
          anti tag coimmunoprecipitation, western blot, pull down, two hybrid
          (Yang and Bashaw, 2006, Fan et al., 2003)
          dock - rst
          bimolecular fluorescence complementation, fluorescence microscopy
          (Kaipa et al., 2013)
          dock - sns
          anti tag coimmunoprecipitation, anti tag western blot, bimolecular fluorescence complementation, fluorescence microscopy
          (Kaipa et al., 2013)
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          dock
          suppressible
          Arp3
          (Stark et al., 2021)
          dock
          enhanceable
          Arpc2
          (Stark et al., 2021)
          dock
          enhanceable
          ckn
          (Weng et al., 2011)
          dock
          enhanceable
          Dscam1
          (Schmucker et al., 2000)
          dock
          enhanceable
          Hem
          (Hummel et al., 2000)
          dock
          suppressible
          msn
          (Ruan et al., 1999)
          dock
          enhanceable
          msn
          (Su et al., 2000)
          dock
          suppressible
          Pak
          (Kamiyama et al., 2015, Hing et al., 1999)
          dock
          enhanceable
          sli
          (Stevens and Jacobs, 2002)
          dock
          enhanceable
          trio
          (Newsome et al., 2000)
          dock
          suppressible
          WASp
          (Stark et al., 2021)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Arpc2
          enhanceable
          dock
          (Stark et al., 2021)
          btl::Egfr
          suppressible
          dock
          (Schnorr et al., 2001)
          ckn
          enhanceable
          dock
          (Weng et al., 2011)
          Dscam1
          enhanceable
          dock
          (Schmucker et al., 2000)
          fru
          suppressible
          dock
          (Goto et al., 2011)
          Hem
          enhanceable
          dock
          (Hummel et al., 2000)
          InR
          suppressible
          dock|Ptp61F
          (Wu et al., 2011)
          msn
          suppressible
          dock
          (Ruan et al., 1999)
          msn
          enhanceable
          dock
          (Ruan et al., 1999)
          Ras85D
          enhanceable
          dock
          (Schnorr et al., 2001)
          robo1|sli
          enhanceable
          dock
          (Fan et al., 2003)
          sli
          enhanceable
          dock
          (Stevens and Jacobs, 2002)
          sli|robo1
          enhanceable
          dock
          (Fan et al., 2003)
          sns
          enhanceable
          dock
          (Kaipa et al., 2013)
          Vrp1
          enhanceable
          dock
          (Kaipa et al., 2013)
          External Data
          Subunit Structure (UniProtKB)
          Interacts (via SH2 and SH3 domains) with Dscam1 (via cytoplasmic domain); the interaction is direct and requires Dscam1 to be phosphorylated (PubMed:10892653). Interacts (via SH2 and SH3 domains) with InR/Insulin-like receptor (via C-terminal cytoplasmic region); the interaction requires InR kinase activity, probably for autophosphorylation stimulated by insulin signaling (PubMed:12702880). Interacts with Ptp61F (via C-terminus); this interaction is independent of insulin stimulation (PubMed:21707536, PubMed:8663600). Interacts (via SH3 domain 2) with Pak (via N-terminal PXXP motif) (PubMed:10399914).
          (UniProt, Q8IPW2 )
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          External Data
          Linkouts
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2L
          Recombination map
          2-1.5
          Cytogenetic map
          21E2-21E2
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          21E2-21E2
          Limits computationally determined from genome sequence between P{lacW}l(2)k09610k09610&P{lacW}Sk09538a and P{PZ}l(2)1068510685&P{lacW}Tango14k00619
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          21D3-21D4
          (determined by in situ hybridisation)
          (Spradling et al., 1999, Garrity et al., 1996)
          21D3-21D4
          (BDGP Project Members, 1994-1999)
          Experimentally Determined Recombination Data
          Location

          2-1.5

          (FlyBase, 2016)

          2-0.7

          (Comeron et al., 2012)

          2-

          (Rao, 1996.5.8)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (16)
          Genomic Clones (10)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (63)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Worby et al., 2002, Worby et al., 2001, Clemens et al., 1996)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

              (Kiger et al., 2003)

              dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

              (Rogers et al., 2003)

              dock facilitates synapse formation by the RP3 motoneuron and is required for guidance of some interneuronal axons. dock mediated signalling may be important in remodelling the RP3 growth cone's cytoskelton.

              (Desai et al., 1999)

              Loss of zygotic dock function causes a selective delay in synapse formation by the RP3 motoneuron at the cleft between muscles 7 and 6. In late stage 16 mutant embryos these muscles often lack innervation. By the third larval instar muscles have become innervated by RP3. dock mutants also show subtle defects in the CNS longitudinal axon pathway.

              (Desai et al., 1999)

              dock can couple signals in either an SH2-dependent or an SH2-independent fashion in photoreceptor growth cones. dock displays different domain requirements in different neurons.

              (Rao and Zipursky, 1998)

              Isolated in a yeast two-hybrid system, by screening for Ptp61F-interacting proteins.

              (Clemens et al., 1996)

              Mutations in dock disrupt photoreceptor cell axon guidance and targeting. Genetic mosaic analysis and cell-type-specific expression of dock transgenes demonstrate dock is required in receptor cells for proper innervation.

              (Garrity et al., 1996)
              Relationship to Other Genes
              Source for database merge of
              Additional comments

              Neuron-specific expression of Hsap\NCK rescues defects in dock mutants.

              (Rao and Zipursky, 1998)
              Nomenclature History
              Source for database identify of

              Source for identity of: dock CG3727

              (Li, 1999.11)
              Nomenclature comments
              Etymology

              The gene is named "dreadlocks" for the appearance of the receptor cell projection pattern in the mutant.

              (Garrity et al., 1996)
              Synonyms and Secondary IDs (12)
              Reported As
              Symbol Synonym
              2L19
              (Bellen, 2020.5.15)
              CG3727
              (National Institute of Genetics Fly Stocks, 2022-, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Berger et al., 2008, Rogers et al., 2003)
              DOCK
              (Dibya et al., 2009)
              Dm0447
              (Teeter et al., 2000)
              Dock
              (Krejčová and Bajgar, 2025, Li et al., 2025, Sanhueza et al., 2025, Xiong et al., 2025, Hizawa et al., 2024, Gilhaus et al., 2023, Liu et al., 2020, Ng and Kurtz, 2020, Zhang et al., 2020, Willoughby et al., 2017, Bothe and Baylies, 2016, Kamiyama et al., 2015, Liu and Lasko, 2015, Li et al., 2014, Tutor et al., 2014, Buszard et al., 2013, Tran et al., 2013, Schoenherr et al., 2012, Wang et al., 2012, Weng et al., 2011, Wu et al., 2011, Erfurth and Schmucker, 2008, Bianco et al., 2007, Rohrbough et al., 2007, Shcherbata et al., 2007, Albin and Davis, 2004, Pramatarova et al., 2003, Muda et al., 2002, Worby et al., 2002, Baas and Luo, 2001, Duchek et al., 2001, Worby et al., 2001, Zhan et al., 2001, Luo, 2000, Stoker and Dutta, 1998, Su et al., 1998, Clemens et al., 1996, Rao, 1996.5.8)
              Nck
              (Tutor et al., 2014, Wang et al., 2012, Hofmann et al., 2004, Rogers et al., 2003, Rogers et al., 2003)
              dck
              (Paricio et al., 1999)
              doc
              (Garcia-Alonso, 1999)
              dock
              (Backlund et al., 2025, Bicanovsky et al., 2025, Collins et al., 2024, Kotian et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Rujano et al., 2022, Stark et al., 2021, Bellen, 2020.5.15, Liu et al., 2020, Luo et al., 2020, Lee and Chen, 2019, Gene Disruption Project members, 2018-, Loyer and Januschke, 2018, Hoi et al., 2016, Sarov et al., 2016, Sanhueza et al., 2015, Ashwal-Fluss et al., 2014, Rudrapatna et al., 2014, Tutor et al., 2014, Abdallah et al., 2013, de Celis et al., 2013.9.11, Kaipa et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Murray et al., 2012, Vanderploeg et al., 2012, Goto et al., 2011, Knox et al., 2011, Shin and Diantonio, 2011, Weng et al., 2011, Berger et al., 2008, Baer et al., 2007, Magalhaes et al., 2007, Shcherbata et al., 2007, Sterling et al., 2007, MacMullin and Jacobs, 2006, Yang and Bashaw, 2006, Hofmann et al., 2004)
              l(2)04723
              Name Synonyms
              Dock
              (Rout et al., 2022)
              Dreadlocks
              (Finegan and Bergstralh, 2020, Li et al., 2014, Tutor et al., 2014, Yang et al., 2012, Wu et al., 2011, Rogers et al., 2003)
              dreadlocks
              (Rudrapatna et al., 2014, Yang and Bashaw, 2006)
              Secondary FlyBase IDs
              • FBgn0041141
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 52 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              References (201)