FB2026_02 , released June 18, 2026
Gene: Dmel\SoxN
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General Information
Symbol
Dmel\SoxN
Species
D. melanogaster
Name
SoxNeuro
Annotation Symbol
CG18024
Feature Type
protein_coding_gene
FlyBase ID
FBgn0029123
Gene Model Status
Current
Stock Availability
106 publicly available
Gene Summary
SoxNeuro (SoxN) encodes an HMG-domain transcription factor. In early embryos it specifies neural progenitors in the central nervous system, while in later embryos it negatively regulates Wg signaling and controls expression of genes required for denticle construction with the product of ovo. [Date last reviewed: 2018-10-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DM64

Key Links
Genomic Location
Cytogenetic map
29F2-29F2
Sequence location
Recombination map
2-34
RefSeq locus
NT_033779 REGION:8825645..8829670
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables chromatin DNA binding
inferred from direct assay
(Girard et al., 2006)
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from direct assay
(Blanco et al., 2005)
enables protein binding
inferred from physical interaction with FLYBASE:SNCF; FB:FBgn0036349
(Bonneaud et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000030384
(GO Reference Genome Project, 2011-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000030384
(GO Reference Genome Project, 2011-)
Biological Process (13 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Girard et al., 2006)
involved_in central nervous system development
inferred from mutant phenotype
(Savare et al., 2005)
involved_in chitin-based larval cuticle pattern formation
inferred from genetic interaction with FLYBASE:wg; FB:FBgn0284084
(Chao et al., 2007)
involved_in negative regulation of canonical Wnt signaling pathway
inferred from mutant phenotype
(Chao et al., 2007)
involved_in nervous system development
inferred from mutant phenotype
(Buescher et al., 2002, Overton et al., 2002)
involved_in positive regulation of transcription by RNA polymerase II
inferred from direct assay
(Blanco et al., 2005)
involved_in regulation of neural precursor cell proliferation
inferred from mutant phenotype
(Bahrampour et al., 2017)
involved_in regulation of neurogenesis
inferred from mutant phenotype
(Bahrampour et al., 2017)
involved_in segment polarity determination
inferred from genetic interaction with FLYBASE:wg; FB:FBgn0284084
(Chao et al., 2007)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in brain development
inferred from biological aspect of ancestor with PANTHER:PTN008496689
(GO Reference Genome Project, 2011-)
involved_in negative regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN008496689
(GO Reference Genome Project, 2011-)
involved_in neuron differentiation
inferred from biological aspect of ancestor with PANTHER:PTN008496689
(GO Reference Genome Project, 2011-)
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000030384
(GO Reference Genome Project, 2011-)
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR022097
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Savare et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000030384
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
SoxNeuro (SoxN) encodes an HMG-domain transcription factor. In early embryos it specifies neural progenitors in the central nervous system, while in later embryos it negatively regulates Wg signaling and controls expression of genes required for denticle construction with the product of ovo. [Date last reviewed: 2018-10-11]
Gene Group (FlyBase)
HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS -
The High mobility group box (HMGB) transcription factors are sequence-specific DNA binding proteins that regulate transcription. The HMGB proteins have a characteristic L-shaped HMGB domain of about 80 amino acid residues, which binds the DNA minor groove and induce DNA bending. The HMGB domains are found in one or more copies and are involved in the regulation of DNA-dependent processes such as transcription, replication and chromatin remodeling. (Adapted from FBrf0194706, FBrf0108466, PMID:24086078 and PMID:23153957).
Pathway (FlyBase)
NEGATIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY -
Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
Summary (Interactive Fly)

HMG1/2 (high mobility group) box transcription factor - essential for the formation of neural progenitor cells in the central nervous system - SoxNeuro and shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\SoxN for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9PCZ7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216885.

Gene model reviewed during 5.44

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
SoxN-RA
FBtr0079733
NM_079996
4026
572
SoxN-RB
FBtr0330210
NM_001273340
4026
761
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
SoxN-PA
FBpp0079335
61.8
572
9.78
Q9VLH8
NP_524735
AAF52712
SoxN-PB
FBpp0303243
81.6
761
9.31
M9PCZ7
NP_001260269
AGB92805
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SoxN using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.34

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 3
embryonic head | precursor
(Cremazy et al., 2000)
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 4 -- 7
procephalic neurogenic region
(Cremazy et al., 2000)
ventral neurectoderm lateral zone

Comment: excluded from ventral midline

(Cremazy et al., 2000)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 8
ventral nerve cord primordium

Comment: NOT ventral midline

(Buescher et al., 2002)
larval central nervous system
(Cremazy et al., 2000)
embryonic stage 9
larval central nervous system | segmentally repeated
(Cremazy et al., 2000)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 10
ventral neurectoderm

Comment: NOT neuroblast

(Buescher et al., 2002)
embryonic neuroblast | subset
(Cremazy et al., 2000)
embryonic stage 11
MP3 precursor
(Wheeler et al., 2006)
embryonic posterior midline glial cell
(Wheeler et al., 2006)
midline glial cell
(Wheeler et al., 2006)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
larval lateral VNC glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 12
ventral nerve cord primordium & presumptive embryonic/larval central nervous system | restricted

Comment: stripe of expression in the ventral nerve cord primordium

(Buescher et al., 2002)
embryonic stage 13
embryonic posterior midline glial cell
(Wheeler et al., 2006)
midline glial cell
(Wheeler et al., 2006)
larval H-cell
(Wheeler et al., 2006)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 17
chordotonal organ
(Cremazy et al., 2000)
epidermis | ventro-lateral
(Cremazy et al., 2000)
larval brain
(Cremazy et al., 2000)
midline glial cell
(Wheeler et al., 2006)
larval H-cell
(Wheeler et al., 2006)
Additional Descriptive Data

Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.

(Wheeler et al., 2006)

Expression of transcript is observed throughout the developing neuroectoderm. Expression is lost in delaminated neuroblasts. While transcript is ubiquitous in the neuroectoderm it is not uniform. In stage 12 embryos transcript can be detected in some cells of the central and peripheral nervous system.

(Buescher et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 7
ventral neurectoderm lateral zone
• nucleus
(Cremazy et al., 2000)
embryonic stage 5 -- 8
ventral ectoderm | ubiquitous
(Overton et al., 2007)
embryonic stage 8
ventral neurectoderm

Comment: NOT ventral midline

(Buescher et al., 2002)
embryonic stage 9 -- 12
embryonic epidermis | restricted
(Overton et al., 2007)
embryonic stage 10
ventral nerve cord primordium

Comment: NOT neuroblast

(Buescher et al., 2002)
embryonic stage 11 -- 13
larval H-cell sib
(Stagg et al., 2011)
embryonic stage 11 -- 17
larval H-cell
(Stagg et al., 2011)
embryonic stage 12
ventral nerve cord primordium | restricted & central nervous system | restricted

Comment: stripe of expression in ventral nerve cord primordium

(Buescher et al., 2002)
embryonic stage 12 -- 17
embryonic/larval epidermis | striped

Comment: 6-cell-wide stripes

(Overton et al., 2007)
embryonic stage 17
chordotonal organ
• nucleus
(Cremazy et al., 2000)
epidermis | ventro-lateral
• nucleus
(Cremazy et al., 2000)
third instar larval stage
eye disc posterior to the morphogenetic furrow
• nucleus
(Cremazy et al., 2001)
antennal disc | restricted
• nucleus
(Cremazy et al., 2001)
second segment of antenna | precursor
• nucleus
(Cremazy et al., 2001)
third segment of antenna | precursor
• nucleus
(Cremazy et al., 2001)
leg disc | restricted
• nucleus
(Cremazy et al., 2001)
neuroblast of embryonic/larval optic lobe
• nucleus
(Cremazy et al., 2001)
larval inner optic anlage
• nucleus
(Cremazy et al., 2001)
larval outer optic anlage
• nucleus
(Cremazy et al., 2001)
abdominal neuroblast
• nucleus
(Cremazy et al., 2001)
thoracic neuroblast
• nucleus
(Cremazy et al., 2001)
T4 neuron
(Schilling et al., 2019)
T5 neuron
(Schilling et al., 2019)
adult stage
T4 neuron
(Schilling et al., 2019)
T5 neuron
(Schilling et al., 2019)
inferred from author statements
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval salivary gland
• nucleus
(Cremazy et al., 2001)
Additional Descriptive Data

SoxN is expressed in all T4/T5 neuron subtypes, but not in their progenitors or in C/T neurons.

(Schilling et al., 2019)

SoxN is expressed in the H-cell and H-cell sib at embryo stage 11 until the end of stage 13. Expression in the H-cell remains on through the end of embryogenesis.

(Stagg et al., 2011)

SoxN protein is expressed throughout the ventral ectoderm from embryonic stage 5 to late stage 8. From stage 9 on, the protein decays. At stage 9 it is present in the entire epithelium, with the exception of the wg expression domain. After stage 9, protein expression further decays. From early stage 12 onwards, expression is reinitiated in segmental stripes of 6-cell width at the lateral periphery of the ventral epidermis. The stripes then expand along the dorsoventral axis and, from stage 13 onwards, span the ventral epidermis. SoxN continues to be expressed in 6-cell-wide stripes until the end of embyrogenesis. During the embryonic stages in which epidermal cell fate is determined, SoxN expression is restricted to the cells that will differentiate to produce denticles. In addition, SoxN protein and D protein were shown to co-localize in the ventral epidermis from stage 12 until the end of embryogenesis.

(Overton et al., 2007)

SoxN proteinexpression largely overlaps the transcript expression in stage 8-10 developing embryos, with expression in the neuroectoderm and absent or strongly reduced in delaminating neuroblasts.

(Buescher et al., 2002)

In the third instar larval antennal disc, SoxN is expressed in three stripes of cells in the part of the disc that will give rise to the to antennal segments 2 and 3. In the eye disc, SoxN is expressed in differentiated photoreceptor cells posterior to the morphogenetic furrow. In the leg discs, SoxN is expressed in a few cells in the center of the disc, and in two lateral patches in the dorsal/posterior and ventral/anterior quadrants. SoxN is also expressed in neuroblasts of the optic proliferation centers and central brain, and in thoracic and abdominal neuroblasts.

(Cremazy et al., 2001)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Savare et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SoxN in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of SoxN
Transgenic constructs containing regulatory region of SoxN
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2L)Exel7040
(Ryder, 2004.4.26)
Df(2L)N22-5
(Overton et al., 2002)
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4pnr-MD237
lethal | male limited, with Scer\GAL4Bx-MS1096
lethal | male limited | cold sensitive, with Scer\GAL4Bx-MS1096
lethal - all die before end of larval stage, with Scer\GAL4unspecified
lethal - all die during embryonic stage
lethal - all die during embryonic stage, with Scer\GAL4da.G32
lethal - all die during embryonic stage, with Scer\GAL4e22c
lethal - all die during embryonic stage (with Df(2L)Exel7040)
partially lethal - majority die, with Scer\GAL4arm.PS
partially lethal - majority die, with Scer\GAL4dpp.blk1
Other Phenotypes
Allele
abnormal neuroanatomy
abnormal neuroanatomy | embryonic stage
abnormal neuroanatomy | embryonic stage 11, with Scer\GAL4da.G32
abnormal neuroanatomy | embryonic stage 11 (with Df(2L)Exel7040)
abnormal neuroanatomy | embryonic stage, with Scer\GAL4da.G32
abnormal neuroanatomy | embryonic stage, with Scer\GAL4elav.PLu
decreased cell number | embryonic stage 11 (with Df(2L)Exel7040)
decreased cell number | embryonic stage 13 (with Df(2L)ED1054)
decreased cell number | embryonic stage 14 (with Df(2L)ED1054)
decreased occurrence of cell division | embryonic stage 13 (with Df(2L)Exel7040)
decreased occurrence of cell division | embryonic stage 14 (with Df(2L)Exel7040)
decreased occurrence of cell division | embryonic stage 16, with Scer\GAL4elav-C155
increased cell number | embryonic stage 11, with Scer\GAL4da.G32
increased occurrence of cell division | embryonic stage 16, with Scer\GAL4elav-C155
increased occurrence of cell division | embryonic stage 17, with Scer\GAL4elav-C155
some die during embryonic stage
some die during embryonic stage, with Scer\GAL4arm.PS
some die during embryonic stage, with Scer\GAL4da.G32
some die during embryonic stage, with Scer\GAL4e22c
some die during embryonic stage (with Df(2L)Exel7040)
some die during larval stage, with Scer\GAL4unspecified
some die during pupal stage, with Scer\GAL4dpp.blk1
visible | female limited, with Scer\GAL4Bx-MS1096
visible | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
adult head, with Scer\GAL4ey.PB
axon & ventral nerve cord
axon & ventral nerve cord, with Scer\GAL4elav.PLu
connective
denticle
denticle | cell autonomous | ectopic, with Scer\GAL4wg.PM
denticle | ectopic, with Scer\GAL4en-e16E
denticle | ectopic, with Scer\GAL4VP16.arm
denticle row | ectopic, with Scer\GAL4e22c
EG neuron
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle, with Df(3R)Espl22, Scer\GAL4e22c
embryonic/first instar larval cuticle, with Scer\GAL4e22c
embryonic/first instar larval cuticle (with Df(2L)Exel7040)
embryonic ganglion mother cell | embryonic stage 13 (with Df(2L)Exel7040)
embryonic ganglion mother cell | embryonic stage 14 (with Df(2L)Exel7040)
embryonic ganglion mother cell | embryonic stage 16, with Scer\GAL4elav-C155
embryonic head
embryonic midgut constriction
embryonic neuroblast
embryonic neuroblast | embryonic stage 11 (with Df(2L)Exel7040)
embryonic neuroblast | embryonic stage 11 | increased number, with Scer\GAL4da.G32
embryonic neuroblast | embryonic stage 13 (with Df(2L)Exel7040)
embryonic neuroblast | embryonic stage 14 (with Df(2L)Exel7040)
embryonic neuroblast | embryonic stage 16, with Scer\GAL4elav-C155
embryonic neuroblast | embryonic stage 17, with Scer\GAL4elav-C155
eye, with Scer\GAL4ey.PB
ganglion mother cell
larval anterior commissure
larval anterior commissure, with Scer\GAL4da.G32
larval anterior commissure, with Scer\GAL4elav.PLu
larval DA1 motor neuron
larval EL neuron
larval glial cell
larval longitudinal connective
larval longitudinal connective, with Scer\GAL4da.G32
larval longitudinal connective, with Scer\GAL4elav.PLu
larval neuron
larval posterior commissure
larval posterior commissure, with Scer\GAL4da.G32
larval posterior commissure, with Scer\GAL4elav.PLu
larval RP2 motor neuron
leg, with Scer\GAL4unspecified
mitotic domain 1 | extended germ band stage
neuroblast MP2
neuroblast NB1-1
neuroblast NB2-1
neuroblast NB2-2
neuroblast NB2-4
neuroblast NB2-5
neuroblast NB3-1
neuroblast NB3-2
neuroblast NB3-3
neuroblast NB3-5
neuroblast NB4-1
neuroblast NB4-2
neuroblast NB4-3
neuroblast NB4-4
neuroblast NB5-1
neuroblast NB5-2
neuroblast NB5-3
neuroblast NB5-4
neuroblast NB5-5
neuroblast NB5-6
neuroblast NB6-1
neuroblast NB6-2
neuroblast NB6-4
neuroblast NB7-1
neuroblast NB7-2
neuroblast NB7-3
neuroblast NB7-4
pCC neuron
stage 1 neuroblast
stage 2 neuroblast
stage 3 neuroblast
stage 4 neuroblast
stage 5 neuroblast
symmetrical commissure
thorax, with Scer\GAL4unspecified
U neuron
ventral denticle belt
ventral denticle belt, with Df(3R)Espl22, Scer\GAL4e22c
ventral denticle belt, with Scer\GAL4e22c
ventral denticle belt (with Df(2L)Exel7040)
wing, with Scer\GAL4unspecified
wing | female limited, with Scer\GAL4Bx-MS1096
wing | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (42)
Hsap\SOX1
6 of 14
Yes
Yes
Hsap\SOX2
6 of 14
Yes
No
1  
Hsap\SOX3
5 of 14
No
Yes
Hsap\SOX4
4 of 14
No
No
Hsap\SOX7
4 of 14
No
No
Hsap\SOX11
4 of 14
No
No
Hsap\SOX12
4 of 14
No
No
1  
Hsap\SOX14
4 of 14
No
No
Hsap\SOX15
4 of 14
No
No
1  
Hsap\SOX17
4 of 14
No
No
1  
Hsap\SOX18
4 of 14
No
No
Hsap\SOX21
4 of 14
No
No
0  
Hsap\SOX8
3 of 14
No
No
Hsap\SOX9
3 of 14
No
No
Hsap\SOX10
3 of 14
No
No
Hsap\SOX13
3 of 14
No
No
Hsap\SRY
3 of 14
No
No
Hsap\BBX
2 of 14
No
No
1  
Hsap\HBP1
2 of 14
No
Yes
Hsap\HMGB1
2 of 14
No
No
1  
Hsap\HMGB2
2 of 14
No
No
Hsap\HMGB3
2 of 14
No
No
1  
Hsap\HMGB4
2 of 14
No
No
Hsap\HMGXB4
2 of 14
No
No
Hsap\SOX5
2 of 14
No
No
Hsap\SOX6
2 of 14
No
No
Hsap\SOX30
2 of 14
No
No
Hsap\CIC
1 of 14
No
No
1  
Hsap\HMG20A
1 of 14
No
No
1  
Hsap\HMG20B
1 of 14
No
No
1  
Hsap\HMGB1P1
1 of 14
No
No
Hsap\HMGXB3
1 of 14
No
Yes
Hsap\LEF1
1 of 14
No
No
2  
Hsap\MEIOSIN
1 of 14
No
Yes
Hsap\SP100
1 of 14
No
No
Hsap\SSRP1
1 of 14
No
No
1  
Hsap\TCF7
1 of 14
No
No
Hsap\TCF7L1
1 of 14
No
No
1  
Hsap\TFAM
1 of 14
No
No
1  
Hsap\TOX3
1 of 14
No
No
Hsap\TOX4
1 of 14
No
No
1  
Hsap\TOX
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (35)
Rnor\Sox2
6 of 14
Yes
No
Rnor\Sox7
4 of 14
No
No
Rnor\Sox8
4 of 14
No
No
Rnor\Sox9
4 of 14
No
No
Rnor\Sox10
4 of 14
No
No
Rnor\Sox11
4 of 14
No
No
Rnor\Sox12
4 of 14
No
No
Rnor\Sox14
4 of 14
No
No
Rnor\Sox17
4 of 14
No
No
Rnor\Sox18
4 of 14
No
No
Rnor\Sox13
3 of 14
No
No
Rnor\Hmg1l1
2 of 14
No
No
Rnor\Hmgb1
2 of 14
No
No
Rnor\Hmgb3
2 of 14
No
No
Rnor\Sry
2 of 14
No
No
Rnor\Bbx
1 of 14
No
No
Rnor\Cic
1 of 14
No
No
Rnor\Hbp1
1 of 14
No
No
Rnor\Hmgb2l1
1 of 14
No
No
Rnor\Hmgb2
1 of 14
No
No
Rnor\Hmgb4
1 of 14
No
No
Rnor\Hmgxb3
1 of 14
No
Yes
Rnor\Hmgxb4
1 of 14
No
No
Rnor\LOC688702
1 of 14
No
Yes
Rnor\LOC103690904
1 of 14
No
Yes
Rnor\LOC108349189
1 of 14
No
No
Rnor\LOC108349258
1 of 14
No
No
Rnor\LOC108350839
1 of 14
No
No
Rnor\RGD1559962
1 of 14
No
No
Rnor\RGD1563668
1 of 14
No
No
Rnor\Sox5
1 of 14
No
No
Rnor\Sox6
1 of 14
No
No
Rnor\Sox30
1 of 14
No
Yes
Rnor\Tcf7l1
1 of 14
No
No
Rnor\Tfam
1 of 14
No
No
Mus musculus (laboratory mouse) (34)
Mmus\Sox1
6 of 14
Yes
Yes
Mmus\Sox2
6 of 14
Yes
No
4  
Mmus\Sox3
5 of 14
No
Yes
Mmus\Sox4
4 of 14
No
No
Mmus\Sox7
4 of 14
No
No
Mmus\Sox9
4 of 14
No
No
Mmus\Sox10
4 of 14
No
No
Mmus\Sox11
4 of 14
No
No
Mmus\Sox12
4 of 14
No
No
Mmus\Sox14
4 of 14
No
No
Mmus\Sox15
4 of 14
No
No
Mmus\Sox17
4 of 14
No
No
Mmus\Sox18
4 of 14
No
No
Mmus\Sox21
4 of 14
No
No
Mmus\Sry
4 of 14
No
No
Mmus\Sox8
3 of 14
No
No
Mmus\Sox13
3 of 14
No
No
Mmus\Hmgb1
2 of 14
No
No
Mmus\Hmgb3
2 of 14
No
No
Mmus\Sox16
2 of 14
No
Yes
Mmus\Sox19
2 of 14
No
Yes
Mmus\Sox30
2 of 14
No
No
Mmus\Bbx
1 of 14
No
No
Mmus\Cic
1 of 14
No
No
Mmus\Hbp1
1 of 14
No
No
Mmus\Hmg20b
1 of 14
No
No
Mmus\Hmgb2
1 of 14
No
No
Mmus\Hmgb4
1 of 14
No
No
Mmus\Hmgxb3
1 of 14
No
Yes
Mmus\Hmgxb4
1 of 14
No
No
Mmus\Meiosin
1 of 14
No
No
Mmus\Sox5
1 of 14
No
No
Mmus\Sox6
1 of 14
No
No
Mmus\Tfam
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (38)
Xtro\sox1
4 of 13
Yes
Yes
Xtro\sox2
4 of 13
Yes
No
Xtro\sox3
4 of 13
Yes
Yes
Xtro\sox17b.1
4 of 13
Yes
No
Xtro\sox17b.2
4 of 13
Yes
No
Xtro\sox4
3 of 13
No
No
Xtro\sox7
3 of 13
No
No
Xtro\sox11
3 of 13
No
No
Xtro\sox14
3 of 13
No
No
Xtro\sox17a
3 of 13
No
No
Xtro\sox18
3 of 13
No
No
Xtro\bbx
2 of 13
No
No
Xtro\hbp1
2 of 13
No
Yes
Xtro\hmgb1
2 of 13
No
No
Xtro\hmgb2
2 of 13
No
No
Xtro\hmgb3
2 of 13
No
No
Xtro\hmgxb4
2 of 13
No
No
Xtro\sox8
2 of 13
No
No
Xtro\sox9
2 of 13
No
No
Xtro\sox10
2 of 13
No
No
Xtro\sox13
2 of 13
No
No
Xtro\cic
1 of 13
No
No
Xtro\hmg20a
1 of 13
No
No
Xtro\hmg20b
1 of 13
No
No
Xtro\LOC116407953
1 of 13
No
No
Xtro\pms1
1 of 13
No
No
Xtro\sox5
1 of 13
No
No
Xtro\sox6
1 of 13
No
No
Xtro\sox15
1 of 13
No
Yes
Xtro\sox21
1 of 13
No
No
Xtro\tcf7l1
1 of 13
No
No
Xtro\tcf7
1 of 13
No
No
Xtro\tfam
1 of 13
No
No
Xtro\tox2
1 of 13
No
No
Xtro\tox3
1 of 13
No
No
Xtro\tox4
1 of 13
No
No
Xtro\tox
1 of 13
No
No
Xtro\vegfc
1 of 13
No
Yes
Danio rerio (Zebrafish) (40)
Drer\sox1a
6 of 14
Yes
Yes
Drer\sox1b
6 of 14
Yes
Yes
Drer\sox2
6 of 14
Yes
No
Drer\sox3
5 of 14
No
No
Drer\sox18
5 of 14
No
No
Drer\sox19b
5 of 14
No
No
Drer\LOC103910042
4 of 14
No
Yes
Drer\sox4a
4 of 14
No
No
Drer\sox7
4 of 14
No
No
Drer\sox11a
4 of 14
No
No
Drer\sox11b
4 of 14
No
No
Drer\sox12
4 of 14
No
No
Drer\sox14
4 of 14
No
No
Drer\sox19a
4 of 14
No
No
Drer\sox21a
4 of 14
No
No
Drer\sox21b
4 of 14
No
No
Drer\sox4b
3 of 14
No
No
Drer\sox8b
3 of 14
No
No
Drer\sox9a
3 of 14
No
No
Drer\sox10
3 of 14
No
No
Drer\sox17
3 of 14
No
No
Drer\sox32
3 of 14
No
No
Drer\hmgb1a
2 of 14
No
No
Drer\hmgb2a
2 of 14
No
No
Drer\hmgb2b
2 of 14
No
No
Drer\sox8a
2 of 14
No
No
Drer\sox9b
2 of 14
No
No
Drer\bbx
1 of 14
No
No
Drer\cica
1 of 14
No
No
Drer\cicb
1 of 14
No
No
Drer\hbp1
1 of 14
No
No
Drer\hmgb1b
1 of 14
No
No
Drer\hmgb3a
1 of 14
No
No
Drer\hmgb3b
1 of 14
No
No
Drer\hmgxb3
1 of 14
No
Yes
Drer\hmgxb4a
1 of 14
No
No
Drer\LOC110438871
1 of 14
No
Yes
Drer\sox13
1 of 14
No
No
Drer\tcf7l1b
1 of 14
No
No
Drer\tfam
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (13)
Cele\sox-3
6 of 14
Yes
No
Cele\sem-2
5 of 14
No
Yes
Cele\sox-2
5 of 14
No
Yes
Cele\sox-4
4 of 14
No
No
Cele\egl-13
3 of 14
No
No
Cele\hmg-1.1
2 of 14
No
No
Cele\hmg-1.2
2 of 14
No
No
Cele\gei-3
1 of 14
No
No
Cele\hmg-3
1 of 14
No
No
Cele\hmg-4
1 of 14
No
No
Cele\hmg-5
1 of 14
No
No
Cele\pop-1
1 of 14
No
No
Cele\swsn-3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (19)
Agam\AgaP_AGAP009957
9 of 12
Yes
Yes
Agam\AgaP_AGAP005183
5 of 12
No
Yes
Agam\AgaP_AGAP010923
5 of 12
No
Yes
Agam\AgaP_AGAP000066
4 of 12
No
Yes
Agam\AgaP_AGAP010919
4 of 12
No
No
Agam\AgaP_AGAP010922
4 of 12
No
No
Agam\AgaP_AGAP012033
4 of 12
No
Yes
Agam\AgaP_AGAP000922
3 of 12
No
No
Agam\AgaP_AGAP012334
2 of 12
No
No
Agam\AgaP_AGAP000005
1 of 12
No
No
Agam\AgaP_AGAP000281
1 of 12
No
No
Agam\AgaP_AGAP001099
1 of 12
No
No
Agam\AgaP_AGAP004789
1 of 12
No
No
Agam\AgaP_AGAP004791
1 of 12
No
No
Agam\AgaP_AGAP008499
1 of 12
No
No
Agam\AgaP_AGAP012335
1 of 12
No
No
Agam\AgaP_AGAP012389
1 of 12
No
No
Agam\AgaP_AGAP012411
1 of 12
No
No
Agam\AgaP_AGAP013411
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (11)
Atha\3xHMG-box1
3 of 13
Yes
No
Atha\3xHMG-box2
3 of 13
Yes
No
Atha\HMGB1
2 of 13
No
No
Atha\HMGB2
2 of 13
No
No
Atha\HMGB3
2 of 13
No
No
Atha\HMGB4
2 of 13
No
No
Atha\HMGB5
2 of 13
No
No
Atha\HMGB6
2 of 13
No
No
Atha\AT2G34450
1 of 13
No
No
Atha\AT5G23405
1 of 13
No
No
Atha\HMG
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\ROX1
3 of 13
Yes
No
Scer\IXR1
2 of 13
No
No
Scer\ABF2
1 of 13
No
No
Scer\NHP6A
1 of 13
No
No
Scer\NHP6B
1 of 13
No
No
Scer\NHP10
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\matmc_1
3 of 12
Yes
No
Spom\matmc_2
3 of 12
Yes
No
Spom\ste11
3 of 12
Yes
No
Spom\cmb1
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:SoxN. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (18)
Sox21a
8 of 13
Sox21b
7 of 13
Sox14
6 of 13
Sox15
6 of 13
Sox100B
6 of 13
D
5 of 13
Sox102F
4 of 13
cic
2 of 13
HmgD
2 of 13
HmgZ
2 of 13
pan
2 of 13
tHMG1
2 of 13
tHMG2
2 of 13
bbx
1 of 13
Dsp1
1 of 13
Hmg-2
1 of 13
Ssrp
1 of 13
TFAM
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
SoxNA34.UAS
model of  X-linked panhypopituitarism
CEA
(Li et al., 2017)
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
SoxNA34.UAS
model of  X-linked panhypopituitarism
is ameliorated by eEF1α1RNAi.UAS.cUa
(Li et al., 2017)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SOX1; SRY-box transcription factor 1
6 of 14
602148
      SOX2; SRY-box transcription factor 2
      6 of 14
      184429
       
      SOX3; SRY-box transcription factor 3
      5 of 14
      313430
      SOX4; SRY-box transcription factor 4
      4 of 14
      184430
      SOX7; SRY-box transcription factor 7
      4 of 14
      612202
          SOX11; SRY-box transcription factor 11
          4 of 14
          600898
          SOX12; SRY-box transcription factor 12
          4 of 14
          601947
               
              SOX14; SRY-box transcription factor 14
              4 of 14
              604747
                  SOX15; SRY-box transcription factor 15
                  4 of 14
                  601297
                       
                      SOX17; SRY-box transcription factor 17
                      4 of 14
                      610928
                       
                      SOX18; SRY-box transcription factor 18
                      4 of 14
                      601618
                      SOX21; SRY-box transcription factor 21
                      4 of 14
                      604974
                           
                          SOX8; SRY-box transcription factor 8
                          3 of 14
                          605923
                              SOX9; SRY-box transcription factor 9
                              3 of 14
                              608160
                              SOX10; SRY-box transcription factor 10
                              3 of 14
                              602229
                              SOX13; SRY-box transcription factor 13
                              3 of 14
                              604748
                                  SRY; sex determining region Y
                                  3 of 14
                                  480000
                                  Functional Complementation Data
                                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                  Interactions
                                  Summary of Physical Interactions
                                  Summary of Genetic Interactions
                                  Interaction Browsers
                                  View in FlyBase Interactions Browser   View in MIST tool (external link)
                                  Please look at the allele data for full details of the genetic interactions
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  SoxN
                                  enhanceable
                                  D
                                  (Overton et al., 2007, Buescher et al., 2002, Overton et al., 2002)
                                  SoxN
                                  enhanceable
                                  pan
                                  (Chao et al., 2007)
                                  SoxN
                                  enhanceable
                                  wor
                                  (Arefin et al., 2019)
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  D
                                  enhanceable
                                  SoxN
                                  (Buescher et al., 2002, Overton et al., 2002)
                                  Egfr
                                  suppressible
                                  SoxN
                                  (Overton et al., 2007)
                                  pan
                                  enhanceable
                                  SoxN
                                  (Chao et al., 2007)
                                  pan
                                  suppressible
                                  SoxN
                                  (Overton et al., 2007)
                                  wg
                                  suppressible
                                  SoxN
                                  (Bejsovec and Chao, 2012, Chao et al., 2007, Overton et al., 2007)
                                  wor
                                  enhanceable
                                  SoxN
                                  (Arefin et al., 2019)
                                  External Data
                                  Linkouts
                                  BioGRID - A database of protein and genetic interactions.
                                  DroID - A comprehensive database of gene and protein interactions.
                                  MIST (genetic) - An integrated Molecular Interaction Database
                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                  Pathways
                                  Signaling Pathways (FlyBase)
                                  Metabolic Pathways
                                  FlyBase
                                  External Links
                                  External Data
                                  Linkouts
                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                  Class of Gene
                                  Genomic Location and Detailed Mapping Data
                                  Chromosome (arm)
                                  2L
                                  Recombination map
                                  2-34
                                  Cytogenetic map
                                  29F2-29F2
                                  Sequence location
                                  FlyBase Computed Cytological Location
                                  Cytogenetic map
                                  Evidence for location
                                  29F2-29F2
                                  Limits computationally determined from genome sequence between P{lacW}l(2)k04003k04003 and P{PZ}tai01351
                                  Experimentally Determined Cytological Location
                                  Cytogenetic map
                                  Notes
                                  References
                                  29F1-29F2
                                  (Girad, 1999.12.21)
                                  Experimentally Determined Recombination Data
                                  Location

                                  2-34

                                  (FlyBase, 2016)

                                  2-29.2

                                  (Comeron et al., 2012)
                                  Left of (cM)
                                  Right of (cM)
                                  Notes
                                  Stocks and Reagents
                                  Stocks (106)
                                  Genomic Clones (17)
                                   

                                  Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                  cDNA Clones (42)
                                   

                                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                  cDNA clones, fully sequenced
                                  BDGP DGC clones
                                  Other clones
                                  Drosophila Genomics Resource Center cDNA clones

                                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                  cDNA Clones, End Sequenced (ESTs)
                                  BDGP DGC clones
                                  Other clones
                                  RNAi and Array Information
                                  Linkouts
                                  DRSC - Results frm RNAi screens
                                  Antibody Information
                                  Laboratory Generated Antibodies
                                   

                                  polyclonal

                                  (Malin et al., 2024, Özel et al., 2022, Ferrero et al., 2014, Buescher et al., 2002)
                                  Commercially Available Antibodies
                                   
                                  Cell Line Information
                                  Publicly Available Cell Lines
                                   
                                    Other Stable Cell Lines
                                     
                                      Other Comments

                                      The sumoylation of the SoxN product regulates its activity in vivo.

                                      (Savare et al., 2005)

                                      One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

                                      (Inlow and Restifo, 2004)

                                      SoxN is required for the formation of the neuroblasts in the central nervous system. SoxN and D appear to be partially functionally redundant with respect to formation of ventral and intermediate neuroblasts.

                                      (Buescher et al., 2002)

                                      Loss of function mutations in SoxN result in a severe reduction in neuroblasts in the lateral and intermediate regions of the central nervous system, whereas ventral neuroblast formation is almost normal.

                                      (Buescher et al., 2002)

                                      SoxN is required for the formation of both early and late forming neuroblasts in the intermediate and lateral columns of the developing central nervous system. D and SoxN have differential and redundant functions during central nervous system development.

                                      (Overton et al., 2002)
                                      Relationship to Other Genes
                                      Source for database merge of

                                      Source for merge of: SoxN CG18024

                                      (FlyBase, 1996-)

                                      Source for merge of: SoxN Sry-rDM64

                                      (FlyBase, 1996-)
                                      Additional comments

                                      The SoxN gene may have been derived from the Sox21b gene by retroposition.

                                      (Pan and Zhang, 2009)

                                      Source for merge of SoxN CG18024 was sequence comparison ( date:000607 ).

                                      (FlyBase, 1996-)
                                      Nomenclature History
                                      Source for database identify of
                                      Nomenclature comments
                                      Etymology
                                      Synonyms and Secondary IDs (14)
                                      Reported As
                                      Symbol Synonym
                                      CG18024
                                      (National Institute of Genetics Fly Stocks, 2022-, Meadows, 2017.1.11, Pan and Zhang, 2009, Perkins et al., 2009, Perkins et al., 2009.1.15, Talamillo et al., 2008, Cremazy et al., 2001)
                                      DM64
                                      (Soullier et al., 1999, Laudet et al., 1993, Picardo, 1992)
                                      SOX29F
                                      (Bowles et al., 2000)
                                      SOXB1
                                      (Bowles et al., 2000)
                                      Sox B1
                                      (Cremazy et al., 2001)
                                      SoxN
                                      (Allen et al., 2026, Allen et al., 2026, Ryu et al., 2026, El-Danaf et al., 2025, Li et al., 2025, Warecki et al., 2025, Drewell et al., 2024, Hunt et al., 2024, Reim, 2024.4.19, Chang, 2022, Clarembaux-Badell et al., 2022, Deshpande et al., 2022, Kanca et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Ray and Li, 2022, Ray et al., 2022, Ing-Simmons et al., 2021, Kvon et al., 2021, Ma et al., 2021, Michki et al., 2021, Parkhitko et al., 2021, Quiquand et al., 2021, Cang and Nie, 2020, Cho et al., 2020, Fuqua et al., 2020, Yaghmaeian Salmani and Thor, 2020, Luna-Peláez et al., 2019, Nil et al., 2019, Schilling et al., 2019, Shokri et al., 2019, Albert et al., 2018, Bischof et al., 2018, Croset et al., 2018, Gene Disruption Project members, 2018-, Janssen et al., 2018, Kittelmann et al., 2018, Karaiskos et al., 2017, Li et al., 2017, Niwa et al., 2016, Sarov et al., 2016, Carl and Russell, 2015, Dequéant et al., 2015, Schertel et al., 2015, dos Santos, 2014, Ferrero et al., 2014, Naval-Sánchez et al., 2013, Shen et al., 2013, Suzuki et al., 2013, Bejsovec and Chao, 2012, Japanese National Institute of Genetics, 2012.5.21, Lloret-Llinares et al., 2012, Jungreis, 2011.11.18, Stagg et al., 2011, Zhai et al., 2011, Kazemian et al., 2010, Phochanukul and Russell, 2010, Eivers et al., 2009, Kantorovitz et al., 2009, Buescher and Chia, 2008, Colomb et al., 2008, Seibert et al., 2008, Bejsovec, 2007.3.20, Bejsovec et al., 2007, Chao et al., 2007, Firth and Baker, 2007, Overton et al., 2007, Seibert et al., 2007, Sessa and Bianchi, 2007, Zeitlinger et al., 2007, Girard et al., 2006, Girardot et al., 2006, Wheeler et al., 2006, Burgler and Macdonald, 2005, McKimmie et al., 2005, Savare et al., 2005, Stathopoulos and Levine, 2005)
                                      SoxNeuro
                                      (Smith et al., 2012)
                                      Sry-rDM64
                                      soxN
                                      (Jasper et al., 2002)
                                      soxNeuro
                                      (Stathopoulos and Newcomb, 2020)
                                      Name Synonyms
                                      Sox-Neuro
                                      (Zhai et al., 2011, Sharma and Nirenberg, 2007)
                                      Sox-neuro
                                      (Bejsovec et al., 2007, Chao et al., 2007, Bejsovec et al., 2006)
                                      SoxNeuro
                                      (Janssen et al., 2018, Dequéant et al., 2015, Naval-Sánchez et al., 2013, Hong et al., 2012, Walker et al., 2011, Carpenter et al., 2009, Eivers et al., 2009, Buescher and Chia, 2008, Talamillo et al., 2008, Chao et al., 2007, Firth and Baker, 2007, Overton et al., 2007, Girard et al., 2006, Wheeler et al., 2006, Chan et al., 2005, Savare et al., 2005, Girad, 1999.12.21)
                                      Sry-related DM64
                                      soxneuro
                                      (Buescher et al., 2002)
                                      Secondary FlyBase IDs
                                      • FBgn0010277
                                      • FBgn0032070
                                      Datasets (0)
                                      Study focus (0)
                                      Experimental Role
                                      Project
                                      Project Type
                                      Title
                                      Study result (0)
                                      Result
                                      Result Type
                                      Title
                                      External Crossreferences and Linkouts ( 48 )
                                      Sequence Crossreferences
                                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                      Other crossreferences
                                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                      FlyMine - An integrated database for Drosophila genomics
                                      InterPro - A database of protein families, domains and functional sites
                                      KEGG Genes - Molecular building blocks of life in the genomic space.
                                      MARRVEL_MODEL - MARRVEL (model organism gene)
                                      Linkouts
                                      BioGRID - A database of protein and genetic interactions.
                                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                      DroID - A comprehensive database of gene and protein interactions.
                                      DRSC - Results frm RNAi screens
                                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                      Flygut - An atlas of the Drosophila adult midgut
                                      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                      MIST (genetic) - An integrated Molecular Interaction Database
                                      MIST (protein-protein) - An integrated Molecular Interaction Database
                                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                      References (162)