FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Mer
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General Information
Symbol
Dmel\Mer
Species
D. melanogaster
Name
Merlin
Annotation Symbol
CG14228
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086384
Gene Model Status
Current
Stock Availability
29 publicly available
Gene Summary
Merlin (Mer) encodes a FERM domain containing protein that promotes assembly of a functional Hippo signaling complex at the apical cell cortex. It has also been associated with cell junctions and endocytic compartments. [Date last reviewed: 2019-02-28] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Dmerlin, BG01543, D-Mer

Key Links
Genomic Location
Cytogenetic map
18E1-18E1
Sequence location
Recombination map
1-64
RefSeq locus
NC_004354 REGION:19689697..19693500
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (52 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:ex; FB:FBgn0004583
(McCartney et al., 2000)
inferred from physical interaction with FLYBASE:arm; FB:FBgn0000117
(McCartney and Fehon, 1996)
inferred from physical interaction with FLYBASE:Moe; FB:FBgn0011661
(McCartney and Fehon, 1996)
inferred from physical interaction with UniProtKB:Q9VFG8
(Yu et al., 2010)
enables protein-membrane adaptor activity
inferred from direct assay
(Yin et al., 2013)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables actin binding
inferred from biological aspect of ancestor with PANTHER:PTN001150648
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR008954, InterPro:IPR011174
(InterPro Project Members, 2004-)
enables cytoskeletal protein binding
inferred from electronic annotation with InterPro:IPR000798
(InterPro Project Members, 2004-)
enables integrin binding
inferred from biological aspect of ancestor with PANTHER:PTN001150649
(GO Reference Genome Project, 2011-)
Biological Process (33 terms)
Terms Based on Experimental Evidence (27 terms)
CV Term
Evidence
References
involved_in axis specification
inferred from mutant phenotype
(MacDougall et al., 2001)
involved_in cell-cell signaling
inferred from expression pattern
(McCartney and Fehon, 1996)
involved_in compound eye morphogenesis
inferred from genetic interaction with FLYBASE:crb; FB:FBgn0259685
(Ling et al., 2010)
involved_in compound eye photoreceptor cell differentiation
inferred from genetic interaction with FLYBASE:ex; FB:FBgn0004583
(Maitra et al., 2006)
involved_in endocytic recycling
inferred from genetic interaction with FLYBASE:ex; FB:FBgn0004583
(Maitra et al., 2006)
involved_in endocytosis
inferred from expression pattern
(McCartney and Fehon, 1996)
involved_in epithelial structure maintenance
inferred from mutant phenotype
(Yang et al., 2012)
involved_in hippo signaling
inferred from mutant phenotype
(Jahanshahi et al., 2016)
involved_in male meiosis cytokinesis
inferred from mutant phenotype
(Dorogova et al., 2008)
involved_in meiotic chromosome separation
inferred from mutant phenotype
(Yudina et al., 2008)
involved_in negative regulation of cell population proliferation
inferred from mutant phenotype
(Pellock et al., 2007, Willecke et al., 2006, McCartney et al., 2000)
inferred from genetic interaction with FLYBASE:ex; FB:FBgn0004583
(Hamaratoglu et al., 2006, McCartney et al., 2000)
inferred from genetic interaction with FLYBASE:CG10939; FB:FBgn0010620
(Abeysundara et al., 2014)
involved_in negative regulation of glial cell proliferation
inferred from mutant phenotype
(Reddy and Irvine, 2011)
involved_in negative regulation of organ growth
inferred from mutant phenotype
(Pellock et al., 2007)
inferred from genetic interaction with FLYBASE:ex; FB:FBgn0004583
(Hamaratoglu et al., 2006)
involved_in pole plasm mRNA localization
inferred from mutant phenotype
(Herpers and Rabouille, 2004)
involved_in positive regulation of apoptotic process
inferred from genetic interaction with FLYBASE:ex; FB:FBgn0004583
(Hamaratoglu et al., 2006)
involved_in positive regulation of cell-cell adhesion
inferred from genetic interaction with FLYBASE:CG10939; FB:FBgn0010620
(Abeysundara et al., 2014)
involved_in positive regulation of hippo signaling
inferred from genetic interaction with FLYBASE:ft; FB:FBgn0001075
(Oh and Irvine, 2008)
inferred from mutant phenotype
(Su et al., 2017, Yin et al., 2013, Baumgartner et al., 2010, Pellock et al., 2007)
inferred from genetic interaction with FLYBASE:ex; FB:FBgn0004583,FLYBASE:hpo; FB:FBgn0261456
(Hamaratoglu et al., 2006)
inferred from direct assay
(Yu et al., 2010)
inferred from genetic interaction with FLYBASE:ex; FB:FBgn0004583,FLYBASE:yki; FB:FBgn0034970
(Hamaratoglu et al., 2009)
inferred from genetic interaction with FLYBASE:l(2)gl; FB:FBgn0002121
(Parsons et al., 2014)
involved_in protein localization to plasma membrane
inferred from mutant phenotype
(Yin et al., 2013)
involved_in R8 cell development
inferred from genetic interaction with FLYBASE:wts; FB:FBgn0011739,FLYBASE:kibra; FB:FBgn0262127
(Sang et al., 2021)
involved_in R8 cell fate specification
inferred from mutant phenotype
(Jukam and Desplan, 2011)
involved_in regulation of cell differentiation
inferred from genetic interaction with FLYBASE:ex; FB:FBgn0004583
(McCartney et al., 2000)
involved_in regulation of cell growth
inferred from expression pattern
(McCartney and Fehon, 1996)
involved_in regulation of cell population proliferation
inferred from mutant phenotype
(LaJeunesse et al., 1998)
involved_in regulation of compound eye retinal cell programmed cell death
inferred from mutant phenotype
(Pellock et al., 2007)
involved_in regulation of signal transduction
inferred from genetic interaction with FLYBASE:ex; FB:FBgn0004583
(Maitra et al., 2006)
involved_in sperm individualization
inferred from mutant phenotype
(Dorogova et al., 2008)
involved_in spermatogenesis
inferred from mutant phenotype
(Dorogova et al., 2008)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
involved_in negative regulation of cell population proliferation
inferred from biological aspect of ancestor with PANTHER:PTN001150649
(GO Reference Genome Project, 2011-)
involved_in positive regulation of early endosome to late endosome transport
inferred from biological aspect of ancestor with PANTHER:PTN001150648
(GO Reference Genome Project, 2011-)
involved_in positive regulation of protein localization to early endosome
inferred from biological aspect of ancestor with PANTHER:PTN001150648
(GO Reference Genome Project, 2011-)
involved_in regulation of cell shape
inferred from biological aspect of ancestor with PANTHER:PTN001150648
(GO Reference Genome Project, 2011-)
involved_in regulation of gliogenesis
inferred from biological aspect of ancestor with PANTHER:PTN000590085
(GO Reference Genome Project, 2011-)
involved_in regulation of hippo signaling
inferred from biological aspect of ancestor with PANTHER:PTN001150649
(GO Reference Genome Project, 2011-)
involved_in regulation of organelle assembly
inferred from biological aspect of ancestor with PANTHER:PTN001150648
(GO Reference Genome Project, 2011-)
Cellular Component (14 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
located_in adherens junction
inferred from direct assay
(McCartney and Fehon, 1996)
located_in apical part of cell
inferred from direct assay
(Yang and Choi, 2021)
located_in apical plasma membrane
inferred from direct assay
(McCartney et al., 2000)
located_in apicomedial cortex
inferred from direct assay
(Su et al., 2017)
located_in cell cortex
inferred from direct assay
(Dorogova et al., 2008)
colocalizes_with cell-cell junction
inferred from direct assay
(Su et al., 2017)
is_active_in cytoplasmic side of apical plasma membrane
inferred from direct assay
(Abeysundara et al., 2014, Yang et al., 2012, Genevet et al., 2010)
located_in cytoplasm
inferred from direct assay
(LaJeunesse et al., 1998, de Cuevas et al., 1996, McCartney and Fehon, 1996)
part_of Kibra-Ex-Mer complex
inferred from direct assay
(Yu et al., 2010)
inferred from physical interaction with FLYBASE:ex; FB:FBgn0004583,FLYBASE:kibra; FB:FBgn0262127
(Genevet et al., 2010)
located_in membrane
inferred from direct assay
(LaJeunesse et al., 1998)
located_in Nebenkern
inferred from direct assay
(Dorogova et al., 2008)
located_in plasma membrane
inferred from direct assay
(de Cuevas et al., 1996)
located_in subapical part of cell
inferred from direct assay
(Yang and Choi, 2021)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
is_active_in adherens junction
inferred from biological aspect of ancestor with PANTHER:PTN000589933
(GO Reference Genome Project, 2011-)
is_active_in apical part of cell
inferred from biological aspect of ancestor with PANTHER:PTN000589933
(GO Reference Genome Project, 2011-)
is_active_in filopodium
inferred from biological aspect of ancestor with PANTHER:PTN001150648
(GO Reference Genome Project, 2011-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000589933
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Merlin (Mer) encodes a FERM domain containing protein that promotes assembly of a functional Hippo signaling complex at the apical cell cortex. It has also been associated with cell junctions and endocytic compartments. [Date last reviewed: 2019-02-28]
Pathway (FlyBase)
POSITIVE REGULATORS OF HIPPO SIGNALING PATHWAY -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of yki, negatively regulating tissue growth (Adapted from FBrf0224870).
Gene Group (FlyBase)
KIBRA-EX-MER COMPLEX -
The KEM complex is an apical protein complex that contains the proteins Kibra, Expanded and Merlin. It positively regulates the Hippo pathway, acting as a scaffolding complex. (Adapted from FBrf0210017).
Protein Function (UniProtKB)
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Mer acts synergistically along with Ex and Kibra to regulate the Hippo signaling pathway.
(UniProt, Q24564)
Summary (Interactive Fly)

ERM family, protein 4.1 superfamily - functions to restrain cell proliferation - a junctional component also associated with endocytosis - the spatial organization of Hippo signaling at the plasma membrane is mediated by the tumor suppressor Merlin/NF2.

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Mer for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q24564)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.51

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mer-RA
FBtr0074754
NM_078689
2503
635
Mer-RB
FBtr0345992
NM_001298529
3400
635
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Mer-PA
FBpp0074523
74.5
635
6.39
Q24564
NP_523413
AAF49005
Mer-PB
FBpp0311877
74.5
635
6.39
Q24564
NP_001285458
AHN59928
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

635 aa isoforms: Mer-PA, Mer-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Moe and arm at the adherens junction (PubMed:8666669). Forms a complex with Kibra and Ex (PubMed:20159598). Interacts (via FERM domain) with Sav (via FBM motif) (PubMed:20159598). Interacts with Schip1 (PubMed:26954546).

(UniProt, Q24564)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mer using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.09

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in adherens junction
inferred from direct assay
(McCartney and Fehon, 1996)
located_in apical part of cell
inferred from direct assay
(Yang and Choi, 2021)
located_in apical plasma membrane
inferred from direct assay
(McCartney et al., 2000)
located_in apicomedial cortex
inferred from direct assay
(Su et al., 2017)
located_in cell cortex
inferred from direct assay
(Dorogova et al., 2008)
colocalizes_with cell-cell junction
inferred from direct assay
(Su et al., 2017)
is_active_in cytoplasmic side of apical plasma membrane
inferred from direct assay
(Abeysundara et al., 2014, Yang et al., 2012, Genevet et al., 2010)
located_in cytoplasm
inferred from direct assay
(LaJeunesse et al., 1998, de Cuevas et al., 1996, McCartney and Fehon, 1996)
part_of Kibra-Ex-Mer complex
inferred from direct assay
(Yu et al., 2010)
inferred from physical interaction with FLYBASE:ex; FB:FBgn0004583,FLYBASE:kibra; FB:FBgn0262127
(Genevet et al., 2010)
located_in membrane
inferred from direct assay
(LaJeunesse et al., 1998)
located_in Nebenkern
inferred from direct assay
(Dorogova et al., 2008)
located_in plasma membrane
inferred from direct assay
(de Cuevas et al., 1996)
located_in subapical part of cell
inferred from direct assay
(Yang and Choi, 2021)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Mer in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 14 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 50 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mer
Transgenic constructs containing regulatory region of Mer
Aberrations (Deficiencies and Duplications) ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | heat sensitive (with Mer1)
lethal | heat sensitive (with Mer2)
lethal | heat sensitive (with Mer4)
lethal | heat sensitive (with Merts1)
lethal | recessive
lethal | recessive | heat sensitive
partially lethal | male | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
male sterile
sterile
Other Phenotypes
Allele
abnormal cytokinesis
abnormal cytokinesis, with Scer\GAL4da.G32, Scer\GAL4nanos.PU
abnormal meiotic cell cycle
abnormal meiotic cell cycle, with Scer\GAL4da.G32
abnormal meiotic cell cycle (with In(1)FM7)
abnormal mitotic cell cycle
abnormal size | adult stage, with Scer\GAL4hh.PU
abnormal size | adult stage, with Scer\GAL4tj.PU
abnormal smell perception
abnormal stress response
decreased cell size | recessive
decreased size | adult stage, with Scer\GAL4GMR.PU
decreased size | adult stage, with Scer\GAL4nub.PU
increased cell number
increased cell number | P-stage | somatic clone - tissue specific
increased cell number | third instar larval stage, with Scer\GAL4repo.PU
increased size | adult stage, with Scer\GAL4en.PU
increased size | adult stage, with Scer\GAL4ptc.PU
increased size | adult stage | somatic clone - tissue specific
visible
visible, with Scer\GAL4ap-md52
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4tj.PU
visible | adult stage, with Scer\GAL4ap.PU
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage, with Scer\GAL4GMR.PU
visible | adult stage, with Scer\GAL4hh.PU
visible | adult stage, with Scer\GAL4nub.PU
visible | adult stage, with Scer\GAL4ptc.PU
visible | recessive
visible | somatic clone
wild-type
Phenotype manifest in
Allele
adult cuticle & head
adult cuticle & head | posterior
adult cuticle & head | ventral
anterior crossvein, with Scer\GAL4en-e16E
egg chamber | posterior & follicle cell | somatic clone | rescuable maternal effect | cell non-autonomous
egg chamber | posterior & follicle cell | supernumerary | conditional ts
elongation stage spermatid
embryonic/first instar larval cuticle & abdominal segment | conditional ts
embryonic/larval optic stalk | third instar larval stage, with Scer\GAL4repo.PU
eye
eye, with Scer\GAL4GMR.PU
eye | anterior | ventral
eye | somatic clone
eye | somatic clone - tissue specific
eye-antennal disc | third instar larval stage
eye disc
eye disc | pupal stage | somatic clone
eye disc morphogenetic furrow
eye disc morphogenetic furrow | ectopic
follicle cell & centrosome & egg chamber | posterior | conditional ts
follicle cell & egg chamber | posterior | conditional ts
individualization stage spermatid
interommatidial bristle & eye disc & pupa
interommatidial bristle | increased number
interommatidial bristle | pupal stage | somatic clone | increased number
interommatidial bristle | somatic clone
interommatidial cell | P-stage | increased number | somatic clone - tissue specific
larval brain | third instar larval stage, with Scer\GAL4repo.PU
larval glial cell | third instar larval stage, with Scer\GAL4repo.PU
Nebenkern, with Scer\GAL4da.G32, Scer\GAL4nanos.PU
nucleus & elongation stage spermatid
ommatidium
ommatidium | somatic clone
oocyte & pericentriolar material | conditional ts
oocyte nucleus
oocyte nucleus | cell non-autonomous | rescuable maternal effect | somatic clone
oocyte nucleus | heat sensitive
photoreceptor neuron | ectopic
posterior crossvein
posterior crossvein, with Scer\GAL4en-e16E
primordial germ cell | heat sensitive
seminal vesicle
spermatocyte
spermatozoon
spindle & spermatocyte
vibrissal bristle
vibrissal bristle | ectopic
wing
wing, with Scer\GAL4ap-md52
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4en.PU
wing, with Scer\GAL4en-e16E
wing, with Scer\GAL4nub.PU
wing, with Scer\GAL4ptc.PU
wing, with Scer\GAL4tj.PU
wing | posterior, with Scer\GAL4hh.PU
wing blade, with Scer\GAL4ap.PU
wing blade posterior compartment, with Scer\GAL4en-e16E
wing disc
wing vein
wing vein, with Scer\GAL4en-e16E
wing vein | ectopic, with Scer\GAL4en-e16E
wing vein L2
wing vein L5, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (36)
Hsap\NF2
14 of 14
Yes
Yes
 
10  
Hsap\EZR
4 of 14
No
No
1  
Hsap\MSN
3 of 14
No
No
Hsap\FRMD4A
2 of 14
No
Yes
Hsap\FRMD4B
2 of 14
No
Yes
Hsap\RDX
2 of 14
No
No
1  
Hsap\ARHGEF7
1 of 14
No
No
1  
Hsap\CCDC120
1 of 14
No
Yes
Hsap\EPB41
1 of 14
No
No
Hsap\EPB41L1
1 of 14
No
No
Hsap\EPB41L2
1 of 14
No
No
1  
Hsap\EPB41L3
1 of 14
No
No
Hsap\EPB41L4A
1 of 14
No
No
Hsap\EPB41L4B
1 of 14
No
No
Hsap\EPB41L5
1 of 14
No
No
Hsap\FARP1
1 of 14
No
No
Hsap\FARP2
1 of 14
No
No
Hsap\FGD4
1 of 14
No
No
Hsap\FGD6
1 of 14
No
No
Hsap\FRMD1
1 of 14
No
No
Hsap\FRMD3
1 of 14
No
No
Hsap\FRMD5
1 of 14
No
No
7  
Hsap\FRMD6
1 of 14
No
No
Hsap\FRMD7
1 of 14
No
No
Hsap\FRMPD2
1 of 14
No
No
Hsap\INAVA
1 of 14
No
Yes
Hsap\LAMB2
1 of 14
No
No
Hsap\MYLIP
1 of 14
No
No
Hsap\PTPN3
1 of 14
No
No
Hsap\PTPN4
1 of 14
No
No
Hsap\PTPN13
1 of 14
No
No
Hsap\PTPN14
1 of 14
No
No
Hsap\PTPN21
1 of 14
No
No
Hsap\TLN1
1 of 14
No
No
Hsap\TLN2
1 of 14
No
No
Hsap\TRIO
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (31)
Rnor\Nf2
14 of 14
Yes
Yes
Rnor\Ezr
4 of 14
No
No
Rnor\Msn
3 of 14
No
No
Rnor\Rdx
3 of 14
No
No
Rnor\Frmd4b
2 of 14
No
Yes
Rnor\Ccdc120
1 of 14
No
Yes
Rnor\Ect2l
1 of 14
No
Yes
Rnor\Epb41l1
1 of 14
No
No
Rnor\Epb41l2
1 of 14
No
No
Rnor\Epb41l3
1 of 14
No
No
Rnor\Epb41l4b
1 of 14
No
No
Rnor\Epb41l5
1 of 14
No
No
Rnor\Epb41
1 of 14
No
No
Rnor\Farp1
1 of 14
No
No
Rnor\Farp2
1 of 14
No
No
Rnor\Fgd3
1 of 14
No
No
Rnor\Fgd4
1 of 14
No
No
Rnor\Fgd5
1 of 14
No
No
Rnor\Frmd5
1 of 14
No
No
Rnor\Frmd6
1 of 14
No
No
Rnor\Frmd7
1 of 14
No
No
Rnor\Frmpd2
1 of 14
No
Yes
Rnor\Inava
1 of 14
No
Yes
Rnor\Kalrn
1 of 14
No
No
Rnor\Ptpn3
1 of 14
No
No
Rnor\Ptpn4
1 of 14
No
No
Rnor\Ptpn13
1 of 14
No
No
Rnor\Ptpn14
1 of 14
No
No
Rnor\Ptpn21
1 of 14
No
No
Rnor\Trio
1 of 14
No
No
Rnor\Vav1
1 of 14
No
No
Mus musculus (laboratory mouse) (30)
Mmus\Nf2
14 of 14
Yes
Yes
Mmus\Ezr
4 of 14
No
No
Mmus\Msn
3 of 14
No
No
Mmus\Frmd4a
2 of 14
No
Yes
Mmus\Frmd4b
2 of 14
No
Yes
Mmus\Frmd7
2 of 14
No
No
Mmus\Rdx
2 of 14
No
No
Mmus\Ccdc120
1 of 14
No
Yes
Mmus\Epb41l1
1 of 14
No
No
Mmus\Epb41l2
1 of 14
No
No
Mmus\Epb41l3
1 of 14
No
No
Mmus\Epb41l4a
1 of 14
No
No
Mmus\Epb41l4b
1 of 14
No
No
Mmus\Epb41l5
1 of 14
No
No
Mmus\Epb41
1 of 14
No
No
Mmus\Farp1
1 of 14
No
No
Mmus\Farp2
1 of 14
No
No
Mmus\Fgd4
1 of 14
No
No
Mmus\Frmd3
1 of 14
No
No
Mmus\Frmd5
1 of 14
No
No
Mmus\Frmd6
1 of 14
No
No
Mmus\Frmpd2
1 of 14
No
Yes
Mmus\Inava
1 of 14
No
Yes
Mmus\Ptpn3
1 of 14
No
No
Mmus\Ptpn4
1 of 14
No
No
Mmus\Ptpn13
1 of 14
No
No
Mmus\Ptpn14
1 of 14
No
No
Mmus\Ptpn21
1 of 14
No
No
Mmus\Trio
1 of 14
No
No
Mmus\Vav1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (20)
Xtro\nf2
6 of 13
Yes
Yes
Xtro\LOC100485014
4 of 13
No
Yes
Xtro\ralgapa1
4 of 13
No
No
Xtro\rhbdd3
2 of 13
No
Yes
Xtro\epb41l3
1 of 13
No
No
Xtro\ezr
1 of 13
No
No
Xtro\farp1
1 of 13
No
No
Xtro\fgd1
1 of 13
No
No
Xtro\frmd3
1 of 13
No
No
Xtro\frmd4a
1 of 13
No
Yes
Xtro\frmd4b
1 of 13
No
Yes
Xtro\frmd6
1 of 13
No
No
Xtro\frmd7
1 of 13
No
No
Xtro\gpr27
1 of 13
No
Yes
Xtro\LOC101731001
1 of 13
No
No
Xtro\msn
1 of 13
No
No
Xtro\mylip
1 of 13
No
No
Xtro\ptpn14
1 of 13
No
No
Xtro\ptpn21
1 of 13
No
No
Xtro\rdx
1 of 13
No
No
Danio rerio (Zebrafish) (40)
Drer\nf2a
14 of 14
Yes
Yes
Drer\nf2b
12 of 14
No
Yes
Drer\ezra
3 of 14
No
No
Drer\ezrb
3 of 14
No
No
Drer\msna
3 of 14
No
No
Drer\frmd4ba
2 of 14
No
Yes
Drer\msnb
2 of 14
No
No
Drer\ccdc120a
1 of 14
No
Yes
Drer\ccdc120b
1 of 14
No
Yes
Drer\epb41a
1 of 14
No
No
Drer\epb41b
1 of 14
No
No
Drer\epb41l3a
1 of 14
No
No
Drer\epb41l3b
1 of 14
No
No
Drer\epb41l4a
1 of 14
No
No
Drer\epb41l4b
1 of 14
No
No
Drer\epb41l5
1 of 14
No
No
Drer\farp1
1 of 14
No
No
Drer\farp2
1 of 14
No
No
Drer\fgd4a
1 of 14
No
No
Drer\fgd4b
1 of 14
No
No
Drer\frmd3
1 of 14
No
No
Drer\frmd4a
1 of 14
No
No
Drer\frmd4bb
1 of 14
No
No
Drer\frmd5b
1 of 14
No
No
Drer\frmd6
1 of 14
No
No
Drer\frmd7
1 of 14
No
No
Drer\frmpd2
1 of 14
No
No
Drer\inavaa
1 of 14
No
Yes
Drer\inavab
1 of 14
No
Yes
Drer\LOC557811
1 of 14
No
No
Drer\LOC570903
1 of 14
No
No
Drer\mylipa
1 of 14
No
No
Drer\ptpn3
1 of 14
No
No
Drer\ptpn4a
1 of 14
No
No
Drer\ptpn4b
1 of 14
No
No
Drer\ptpn13
1 of 14
No
Yes
Drer\ptpn21
1 of 14
No
No
Drer\si:dkey-91m11.5
1 of 14
No
No
Drer\si:dkey-178k16.1
1 of 14
No
No
Drer\zgc:172136
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (14)
Cele\nfm-1
4 of 14
Yes
Yes
Cele\erm-1
2 of 14
No
No
Cele\epi-1
1 of 14
No
No
Cele\exc-5
1 of 14
No
No
Cele\F07C6.4
1 of 14
No
Yes
Cele\frm-1
1 of 14
No
No
Cele\frm-2
1 of 14
No
No
Cele\frm-3
1 of 14
No
No
Cele\frm-4
1 of 14
No
No
Cele\frm-5.1
1 of 14
No
Yes
Cele\frm-5.2
1 of 14
No
No
Cele\frm-7
1 of 14
No
No
Cele\ptp-1
1 of 14
No
No
Cele\tln-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (14)
Agam\AgaP_AGAP010346
12 of 12
Yes
Yes
Agam\MOEH_ANOGA
2 of 12
No
No
Agam\AgaP_AGAP001287
1 of 12
No
No
Agam\AgaP_AGAP001609
1 of 12
No
No
Agam\AgaP_AGAP001632
1 of 12
No
No
Agam\AgaP_AGAP004136
1 of 12
No
No
Agam\AgaP_AGAP007130
1 of 12
No
No
Agam\AgaP_AGAP007474
1 of 12
No
No
Agam\AgaP_AGAP008413
1 of 12
No
No
Agam\AgaP_AGAP008811
1 of 12
No
No
Agam\AgaP_AGAP009126
1 of 12
No
No
Agam\AgaP_AGAP009975
1 of 12
No
No
Agam\AgaP_AGAP012185
1 of 12
No
No
Agam\AgaP_AGAP013042
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Mer. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (15)
Moe
5 of 13
Cdep
1 of 13
CG34347
1 of 13
cora
1 of 13
dnr1
1 of 13
ex
1 of 13
Frmd5
1 of 13
pbl
1 of 13
Pez
1 of 13
Ptpmeg
1 of 13
rhea
1 of 13
RhoGEF4
1 of 13
sstn
1 of 13
trio
1 of 13
yrt
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Mer4
model of  cancer
CEA with exe1
(Hamaratoglu et al., 2006)
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 2 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
NF2; NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
14 of 14
NF2, MOESIN-EZRIN-RADIXIN-LIKE (MERLIN) TUMOR SUPPRESSOR; NF2
 
EZR; ezrin
4 of 14
123900
       
      MSN; moesin
      3 of 14
      309845
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Dmel gene
      Ortholog showing functional complementation
      Supporting References
      Mer
      Hsap\NF2
      (Gavilan et al., 2014)
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Mer
      cosedimentation, molecular weight estimation by staining, isothermal titration calorimetry, predetermined participant, pull down, western blot, x-ray crystallography, anti tag coimmunoprecipitation, anti tag western blot, molecular sieving, protein cross-linking with a bifunctional reagent
      (Guo et al., 2024, Zhang et al., 2021, Yin et al., 2013, Benseñor et al., 2010)
      Mer - Ars2
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - CCT2
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - CCT6
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - CG10939
      anti tag coimmunoprecipitation, western blot, pull down, autoradiography
      (Abeysundara et al., 2014)
      Mer - Cam
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - Chc
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - Dhc64C
      pull down, western blot, anti bait coimmunoprecipitation
      (Benseñor et al., 2010)
      Mer - ERp60
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - Eno
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - Fim
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - Khc
      anti bait coimmunoprecipitation, western blot, pull down
      (Benseñor et al., 2010)
      Mer - Mnat9
      anti bait coimmunoprecipitation, anti tag western blot
      (Mok and Choi, 2022)
      Mer - Myo31DF
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - Myo61F
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - Ote
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - Past1
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - Patronin
      anti tag coimmunoprecipitation, western blot
      (Yang and Choi, 2021)
      Mer - Rab7
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - Ran
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - RpL4
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - RpS18
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - RpS8
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - Schip1
      anti bait coimmunoprecipitation, western blot, anti tag western blot, pull down
      (Chung et al., 2016)
      Mer - Sik2
      anti tag coimmunoprecipitation, anti tag western blot
      (Wehr et al., 2013)
      Mer - Slik
      pull down, autoradiography
      (Hughes and Fehon, 2006)
      Mer - TER94
      anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
      (Li et al., 2024, Kwon et al., 2013)
      Mer - Tctp
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - ck
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - didum
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - ed
      anti tag coimmunoprecipitation, anti tag western blot
      (Yue et al., 2012)
      Mer - ex
      far western blotting, tag visualisation, anti tag coimmunoprecipitation, anti tag western blot, western blot
      (Li et al., 2024, Yang and Choi, 2021, McCartney et al., 2000)
      Mer - fax
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - flw
      anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot
      (Yang et al., 2012)
      Mer - hpo
      anti tag coimmunoprecipitation, anti tag western blot
      (Reddy and Irvine, 2011)
      Mer - jar
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - kibra
      anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot
      (Li et al., 2024, Tokamov et al., 2021, Baumgartner et al., 2010, Genevet et al., 2010, Yu et al., 2010)
      Mer - kst
      anti tag coimmunoprecipitation, western blot, anti tag western blot
      (Fletcher et al., 2015)
      Mer - ref(2)P
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - sav
      anti tag coimmunoprecipitation, western blot, anti tag western blot, two hybrid
      (Wehr et al., 2013, Yu et al., 2010)
      Mer - shrb
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - slmb
      anti tag coimmunoprecipitation, anti tag western blot
      (Tokamov et al., 2021)
      Mer - tum
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Mer - wts
      anti tag coimmunoprecipitation, anti tag western blot
      (Li et al., 2024, Yin et al., 2013)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Mer
      suppressible
      bs
      (LaJeunesse et al., 2001)
      Mer
      enhanceable
      bs
      (LaJeunesse et al., 2001)
      Mer
      enhanceable
      crb
      (Ling et al., 2010)
      Mer
      enhanceable
      dpp
      (McCartney et al., 2000)
      Mer
      enhanceable
      E(Mer)IIb
      (LaJeunesse et al., 2001)
      Mer
      enhanceable
      E(Mer)IIIa
      (LaJeunesse et al., 2001)
      Mer
      enhanceable
      ex
      (Willecke et al., 2006, McCartney et al., 2000)
      Mer
      enhanceable
      ft
      (Willecke et al., 2006)
      Mer
      suppressible
      grk
      (MacDougall et al., 2001)
      Mer
      enhanceable
      kibra
      (Yu et al., 2010)
      Mer
      enhanceable
      mtm
      (Hu et al., 2022)
      Mer
      suppressible
      net
      (LaJeunesse et al., 2001)
      Mer
      enhanceable
      net
      (LaJeunesse et al., 2001)
      Mer
      enhanceable
      sav
      (Yin et al., 2013)
      Mer
      enhanceable
      sbb
      (LaJeunesse et al., 2001)
      Mer
      enhanceable
      Slik
      (Hughes and Fehon, 2006)
      Mer
      suppressible
      Tao
      (Poon et al., 2011)
      Mer
      suppressible
      TER94
      (Li et al., 2024)
      Mer
      suppressible
      yki
      (Reddy and Irvine, 2011)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      bs
      enhanceable
      Mer
      (LaJeunesse et al., 2001)
      E(Mer)IIb
      enhanceable
      Mer
      (LaJeunesse et al., 2001)
      E(Mer)IIIa
      enhanceable
      Mer
      (LaJeunesse et al., 2001)
      ex
      enhanceable
      Mer
      (McCartney et al., 2000)
      ft
      enhanceable
      Mer
      (Silva et al., 2006)
      kibra
      enhanceable
      Mer
      (Baumgartner et al., 2010, Yu et al., 2010)
      kibra
      suppressible
      Mer
      (Genevet et al., 2010)
      Mnat9
      suppressible
      Mer
      (Mok and Choi, 2022)
      mtm
      enhanceable
      Mer
      (Hu et al., 2022)
      net
      enhanceable
      Mer
      (LaJeunesse et al., 2001)
      Patronin
      suppressible
      Mer
      (Yang and Choi, 2021)
      sav
      enhanceable
      Mer
      (Yin et al., 2013)
      sbb
      enhanceable
      Mer
      (LaJeunesse et al., 2001)
      Snr1
      suppressible
      Mer
      (Jeibmann et al., 2014)
      TER94
      suppressible
      Mer
      (Li et al., 2024)
      External Data
      Subunit Structure (UniProtKB)
      Interacts with Moe and arm at the adherens junction (PubMed:8666669). Forms a complex with Kibra and Ex (PubMed:20159598). Interacts (via FERM domain) with Sav (via FBM motif) (PubMed:20159598). Interacts with Schip1 (PubMed:26954546).
      (UniProt, Q24564 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      X
      Recombination map
      1-64
      Cytogenetic map
      18E1-18E1
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      18E1-18E1
      Limits computationally determined from genome sequence between P{EP}Sec61γEP1511 and P{EP}EP1116&P{EP}EP1344EP1344
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      18E-18E
      (Fehon, 1996.2.21)
      18D-18E
      (determined by in situ hybridisation)
      (Fehon et al., 1997)
      Experimentally Determined Recombination Data
      Location

      1-64

      (FlyBase, 2016)

      1-62.4

      (Comeron et al., 2012)

      1-

      (Fehon, 1996.2.21)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (29)
      Genomic Clones (10)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (23)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Yang et al., 2012)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)

          dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

          (Rogers et al., 2003)

          Mer is specifically required only in the posterior follicle cells to initiate axis formation in the oocyte. It is not required to specify posterior follicle cell identity in response to the grk signal from the oocyte, but is required for the unknown polarising signal back to the oocyte. Mer is also required non-autonomously to maintain cell polarity and limit proliferation in the posterior follicle cells (that have received the grk signal), but is not required in embryos and larvae.

          (MacDougall et al., 2001)

          Mer and ex function cooperatively in regulating cell proliferation and differentiation in developing epithelial cells.

          (McCartney et al., 2000)

          Mer is not allelic to btdl.

          (Fehon et al., 1997)

          Mer and Moe are frequently coexpressed in developing tissues, but their subcellular localisations are distinct. Moe shows continuous plasma membrane association and Mer is localised in punctate structures that are associated with both the plasma membrane and the cytoplasm. Mer is associated with endocytic compartments in cultured cells.

          (McCartney and Fehon, 1996)

          The Mer gene product is not a component of fusomes.

          (de Cuevas et al., 1996)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: Mer BG01543

          (Sambandan et al., 2006)
          Additional comments

          The gene referred to in FlyBase as "mer" (FBgn0041733) is not the same gene as that referred to in FlyBase as "Mer" (FBgn0086384) - they are on different chromosomes.

          (FlyBase, 1992-)
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (15)
          Reported As
          Symbol Synonym
          BG01543
          (Sambandan et al., 2006)
          CG14228
          (Trivedi et al., 2020, Meadows, 2017.9.14, Balakrishnan et al., 2015, Jeibmann et al., 2014, Ni et al., 2011.7.19, Perkins et al., 2009, Rogers et al., 2003, Goldstein and Gunawardena, 2000)
          D-Mer
          (Yudina et al., 2010, Dorogova et al., 2008)
          Dmerlin
          (Cereijido et al., 2003, Muller, 2000, de Cuevas et al., 1996, Fehon, 1996.2.21, McCartney and Fehon, 1996, McCartney and Fehon, 1995, McCartney and Fehon, 1995, McCartney and Fehon, 1994)
          EMR2
          (Winge, 1995.3.30)
          Emr2
          MER
          (Grifoni et al., 2013, Harvey and Hariharan, 2012)
          Mer
          (Kong et al., 2025, Kroeger et al., 2024, Miao et al., 2024, Ecovoiu et al., 2022, Li et al., 2022, Yang et al., 2022, Bilder et al., 2021, Cho and Jiang, 2021, Gong et al., 2021, Johnson and Leatherman, 2021, Pojer et al., 2021, Tokamov et al., 2021, Yang and Choi, 2021, Gou et al., 2020, van Soldt and Cardoso, 2020, Chang et al., 2019, Gokhale and Pfleger, 2019, Jiménez-Martínez et al., 2019, Snigdha et al., 2019, Xu et al., 2019, Yee et al., 2019, Bae and Luo, 2018, Camuglia et al., 2018, Elbediwy and Thompson, 2018, Fletcher et al., 2018, Fulford et al., 2018, Parasram et al., 2018, Richardson and Portela, 2017, Su et al., 2017, Transgenic RNAi Project members, 2017-, Fallahi et al., 2016, Hu et al., 2016, Meng et al., 2016, Yadav et al., 2016, Cao et al., 2015, Doggett et al., 2015, Irvine and Harvey, 2015, Keder et al., 2015, Panneton et al., 2015, Sun et al., 2015, Zheng et al., 2015, Abeysundara et al., 2014, Gavilan et al., 2014, Sadeqzadeh et al., 2014, Tipping and Perrimon, 2014, Andersen et al., 2013, Deng et al., 2013, Ilanges et al., 2013, Johnston, 2013, Kwon et al., 2013, Kwon et al., 2013, Lucas et al., 2013, Matsui and Lai, 2013, Vaque et al., 2013, Wehr et al., 2013, Yin et al., 2013, Yu and Guan, 2013, Fabian and Brill, 2012, Fausti et al., 2012, Hafezi et al., 2012, Jin et al., 2012, Liu et al., 2012, Poernbacher et al., 2012, Yue et al., 2012, Bao et al., 2011, Boggiano et al., 2011, Carreira et al., 2011, Chan et al., 2011, Dubatolova et al., 2011, Fernández et al., 2011, Genevet and Tapon, 2011, Halder and Johnson, 2011, Poon et al., 2011, Reddy and Irvine, 2011, Richter et al., 2011, Salah and Aqeilan, 2011, Tiwari et al., 2011, Toku et al., 2011, Zhao et al., 2011, Baumgartner et al., 2010, Baumgartner et al., 2010, Benseñor et al., 2010, Dubatolova et al., 2010, Dubatolova et al., 2010, Genevet et al., 2010, Kopyl et al., 2010, Kopyl et al., 2010, LaJeunesse, 2010, Lebedeva et al., 2010, Lebedeva et al., 2010, Milton et al., 2010, Pirraglia et al., 2010, Popodi et al., 2010-, Reddy et al., 2010, Robinson et al., 2010, Venken et al., 2010, Yudina et al., 2010, Yu et al., 2010, Yu et al., 2010, Genevet et al., 2009, Hamaratoglu et al., 2009, Omelyanchuk et al., 2009, Mensch et al., 2008, Oh and Irvine, 2008, Willecke et al., 2008, Yudina et al., 2008, Zhao et al., 2008, Bakal et al., 2007, Hamaratoglu et al., 2007, Rasmussen and Kellis, 2007, Cho et al., 2006, Edgar, 2006, Hamaratoglu et al., 2006, Hariharan, 2006, Hughes and Fehon, 2006, Maitra et al., 2006, Maitra et al., 2006, Silva, 2006, Silva et al., 2006, Stanyon et al., 2004, Johnston and Gallant, 2002, McCartney et al., 2000, Pickeral et al., 2000)
          Merlin
          (Garland et al., 2021, Gogia et al., 2021)
          NF2
          (Vaqué et al., 2013)
          mer
          (Guo et al., 2024, Hu et al., 2022, Badmos et al., 2021, Sang et al., 2021, Aguilar-Aragon et al., 2020, Khadilkar and Tanentzapf, 2019, Chung et al., 2016, Jahanshahi et al., 2016, Keder et al., 2015, Kwon et al., 2015, Li et al., 2015, Wang and Baker, 2015, Wong et al., 2015, Huang and Kalderon, 2014, Jukam et al., 2013, Jukam et al., 2013, Vaqué et al., 2013, Fabian and Brill, 2012, Jukam and Desplan, 2011, Chen et al., 2010, Genevet et al., 2010, Ling et al., 2010, Thomson and Johnson, 2010, Yu et al., 2010, Classen et al., 2009, Genevet et al., 2009, Hamaratoglu et al., 2009, Sun et al., 2008, Yu et al., 2008, Zhao et al., 2008, Pellock et al., 2007, Polesello and Tapon, 2007, Edgar, 2006, Hamaratoglu et al., 2006, Silva et al., 2006, Willecke et al., 2006)
          Name Synonyms
          BG01543
          D Merlin
          (Lopez-Schier, 2003)
          Dmerlin
          (Cereijido et al., 2003)
          Ezrin-moesin-radixin-2
          Merlin
          (Gou et al., 2023, Aguilar-Aragon et al., 2020, Chen et al., 2020, Fujisawa et al., 2020, Jiménez-Martínez et al., 2019, Kim and Jho, 2018, Sun et al., 2017, Fletcher et al., 2015, Hariharan, 2015, Thompson and Sahai, 2015, Sadeqzadeh et al., 2014, Deng et al., 2013, Huang et al., 2013, Konsavage and Yochum, 2013, Kwon et al., 2013, Lucas et al., 2013, Rister et al., 2013, Yu and Guan, 2013, Adamson and Lajeunesse, 2012, Fabian and Brill, 2012, Fausti et al., 2012, Bao et al., 2011, Halder and Johnson, 2011, Jukam and Desplan, 2011, Poon et al., 2011, Reddy and Irvine, 2011, Salah and Aqeilan, 2011, Yan et al., 2011, Baumgartner et al., 2010, Genevet et al., 2010, LaJeunesse, 2010, Ling et al., 2010, Milton et al., 2010, Pertceva et al., 2010, Reddy et al., 2010, Yudina et al., 2010, Yu et al., 2010, Hamaratoglu et al., 2009, Dorogova et al., 2008, Mensch et al., 2008, Oh and Irvine, 2008, Sambandan et al., 2008, Bakal et al., 2007, Dorogova et al., 2007, Hamaratoglu et al., 2007, Jukam and Desplan, 2007, Li and Baker, 2007, Polesello and Tapon, 2007, Willecke et al., 2007, Cho et al., 2006, Edgar, 2006, Hamaratoglu et al., 2006, Hariharan, 2006, Hawley and Gilliland, 2006, Hughes and Fehon, 2006, Maitra et al., 2006, Sambandan et al., 2006, Silva et al., 2006, Willecke et al., 2006, Rogers et al., 2003, Johnston and Gallant, 2002, Maitra and Fehon, 2002, Riechmann and Ephrussi, 2001, McCartney et al., 2000, Bassett et al., 1997, Fehon et al., 1997)
          Merlin/Neurofibromin 2
          (Thomson and Johnson, 2010)
          merlin
          (Khadilkar and Tanentzapf, 2019, Yuan et al., 2019, Campbell et al., 2018, Kwon et al., 2015, Abeysundara et al., 2014, Jeibmann et al., 2014, Ukken et al., 2014, Harvey et al., 2013, Jukam et al., 2013, Chen et al., 2010, Jukam and Claude, 2008, Sun et al., 2008, Yu et al., 2008, Pellock et al., 2007, Edgar, 2006, Golovnina et al., 2005, Herpers and Rabouille, 2004, Rogers et al., 2003, Turunen et al., 1998, McCartney and Fehon, 1996)
          Secondary FlyBase IDs
          • FBgn0013951
          • FBgn0070004
          • FBgn0014341
          Datasets (1)
          Study focus (1)
          Experimental Role
          Project
          Project Type
          Title
          • bait_protein
          Hippo_Pathway_interaction_map
          Interaction map generated by purification of Hippo pathway factors, with identification of copurifying proteins by mass spectrometry.
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 60 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          PDB - An information portal to biological macromolecular structures
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (308)