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FB2025_05
,
released December 11, 2025
Ca-P60A, dSERCA, Kum, Calcium ATPase at 60A, CaP60A
endoplasmic reticulum calcium pump - mutants disrupt Wingless signaling by sequestering Armadillo/beta-catenin away from the signaling pool - Seipin interacts with SERCA, whose activity is reduced in dSeipin mutants, leading to reduced ER calcium levels - THADA binds SERCA and acts on it as an uncoupler - tracheal budding
Please see the JBrowse view of Dmel\SERCA for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.52
4.5 (northern blot)
1002 (aa); 110 (kD)
Interacts with SclA and SclB.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SERCA using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
In situ hybridization to sections of adult flies shows that Ca-P60A transcripts are detected in each tissue tested, generally at a low level. High transcript levels are observed in the central nervous system and in muscles. Strong expression is apparent in the visual system, in ganglion cells around the ocelli, and in the antennal center. It is also apparent in the muscles of the proboscis, the cibarial pump, the lateral pharyngeal muscles, and the salivary muscles. High expression is also seen in some muscles of the mesothorax and in the jump muscles. Finally, elevated levels are observed in oocytes.
Ca-P60A transcripts are present in adult-males and females. None are detected in embryos, larvae, or pupae.
JBrowse - Visual display of RNA-Seq signals
View Dmel\SERCA in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Treatment of S2 cells with dsRNA made from templates generated with primers directed against this gene significantly increases the resting Ca2+ concentration, reduces the store release transient upon addition of thapsigargin, and strongly suppresses Ca2+ influx upon readdition of external Ca2+.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
1 allele of l(2)SH0211 recovered in a P-insertion screen.
Area matching Drosophila organellar-type Ca-ATPase gene, Acc. No. X84681.
Flies carrying Ca-P60A mutations paralyse within 3 minutes at 40oC and remain immobile up to two days on shifting back to the permissive temperature.
Ca-P60A show neither a maternal nor a zygotic neurogenic phenotype.
Analysis of the conserved core sequence in 159 P-type ATPases from the 3 domains of life (Archaea, Bacteria and Eukarya) establishes 5 major groups of P-type ATPases.
There is a single Ca-P60A gene in the Drosophila genome.
Source for merge of: Ca-P60A CG3725
Source for merge of: Ca-P60A Kum
Source for merge of: Ca-P60A l(2)SH0211
Source for identity of: SERCA Ca-P60A
Changed symbol from 'Ca-P60A' to 'SERCA' to reflect preferred usage in the literature.
The gene is named "Kumbhakarna" based on the mutant phenotype; when restored to the permissive temperature, "Kumbhakarna" mutants show prolonged paralysis of 6-48 hours, the duration of paralysis depending on the duration of prior exposure to the restrictive temperature. "Kumbhakarna" is a mythological hero who slept for 6 months of the year.
