FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\robo3
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General Information
Symbol
Dmel\robo3
Species
D. melanogaster
Name
roundabout 3
Annotation Symbol
CG5423
Feature Type
protein_coding_gene
FlyBase ID
FBgn0041097
Gene Model Status
Current
Stock Availability
96 publicly available
Gene Summary
roundabout 3 (robo3) encodes a member of the Robo receptor family that uses the secreted glycoprotein encoded by sli as ligand. It is involved in the development of the nervous system and gonad. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Robo, Robo-3

Key Links
Genomic Location
Cytogenetic map
21F3-21F4
Sequence location
Recombination map
2-2
RefSeq locus
NT_033779 REGION:1256417..1296596
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Jhaveri et al., 2004, Rajagopalan et al., 2000)
involved_in central complex development
inferred from mutant phenotype
(Nicolas and Preat, 2005)
involved_in gonad development
inferred from mutant phenotype
(Weyers et al., 2011)
involved_in mushroom body development
inferred from mutant phenotype
(Nicolas and Preat, 2005)
involved_in neuron recognition
inferred from mutant phenotype
(Zlatic et al., 2003)
involved_in synaptic target inhibition
inferred from mutant phenotype
(Oliva et al., 2016)
inferred from genetic interaction with FLYBASE:robo2; FB:FBgn0002543
(Oliva et al., 2016)
involved_in ventral cord development
inferred from mutant phenotype
(Rajagopalan et al., 2000)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in sarcomere organization
inferred from biological aspect of ancestor with PANTHER:PTN002675417
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Katsuki et al., 2009)
located_in plasma membrane
inferred from direct assay
(Oliva et al., 2016)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
roundabout 3 (robo3) encodes a member of the Robo receptor family that uses the secreted glycoprotein encoded by sli as ligand. It is involved in the development of the nervous system and gonad. [Date last reviewed: 2019-09-12]
Gene Group (FlyBase)
ROUNDABOUT -
The Roundabout genes encode transmembrane receptors that mediate repulsive cues by binding to midline repellent sli and regulate axon guidance. (Adapted from FBrf0210796).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\robo3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VPZ7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Gene model reviewed during 6.32

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
robo3-RA
FBtr0077921
NM_134748
5504
1342
robo3-RC
FBtr0479835
NM_001382178
6028
1336
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
robo3-PA
FBpp0077587
144.7
1342
8.73
Q9VPZ7
NP_608592
AAF51387
robo3-PC
FBpp0428169
144.6
1336
8.76
AGB92403
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\robo3 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.58

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
chordotonal organ | subset
(Zlatic et al., 2003)
embryonic stage 13 -- 15
presumptive embryonic/larval central nervous system
(Parsons et al., 2003)
gonad
(Weyers et al., 2011)
third instar larval stage
photoreceptor cell R8

Comment: growth cones

(Pappu et al., 2011)
wandering third instar larval stage
embryonic/larval optic lobe
(Tayler et al., 2004)
medulla anlage
(Tayler et al., 2004)
neuron of inner optic anlage lateral proliferation zone
(Tayler et al., 2004)
photoreceptor neuron
• axon
(Tayler et al., 2004)
prepupal stage P1 -- pupal stage P6
olfactory receptor neuron | medial
• axon

Comment: 0-24 hr APF; medial surface of antennal lobe

(Jhaveri et al., 2004)
pupal stage
olfactory receptor neuron | medial
• axon
(Jhaveri et al., 2004)
antennal lobe | medial | restricted
• axon
(Jhaveri et al., 2004)
pharate adult stage P9
antennal lobe glomerulus | subset
• axon

Comment: at 60 hr APF; several, not identified

(Jhaveri et al., 2004)
antennal lobe glomerulus DA1
• axon

Comment: at 60 hr APF

(Jhaveri et al., 2004)
Additional Descriptive Data

robo3 is expressed specifically and transiently in photoreceptor R8 growth cones. robo3 is expressed in third instar larval R8 growth cones as they enter the optic lobe, displays a graded pattern of staining with decreased staining in axons extending further toward their final layer, and is downregulated shortly after the R8 axons enter the medulla neuropil. However, residual robo3 staining is observed in the growth cones of other optic lobe neurons that project into more proximal regions of the developing medulla neuropil.

(Pappu et al., 2011)

robo3 is observed in the embryonic gonad.

(Weyers et al., 2011)

robo1, robo2, and robo3 proteins are expressed in overlapping patterns in the larval central nervous system and developing visual system.

(Tayler et al., 2004)

Staining of robo3 was detected in the embryonic central nervous system but no staining was observed in the periphery.

(Parsons et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Katsuki et al., 2009)
located_in plasma membrane
inferred from direct assay
(Oliva et al., 2016)
Expression Deduced from Reporters
Reporter: P{GawB}NP4968
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
photoreceptor cell R8
(Pappu et al., 2011)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\robo3 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 23 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of robo3
Transgenic constructs containing regulatory region of robo3
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2L)ast5
(Rajagopalan et al., 2000)
Df(2L)Exel7006
(Weyers et al., 2011, Ryder, 2004.4.26)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
abnormal neurophysiology | partially, with Scer\GAL4shakB.lethal.4.1
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with Df(2L)Exel7006)
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4109(2)80
abnormal neuroanatomy, with Scer\GAL4c17
abnormal neuroanatomy, with Scer\GAL4eg-Mz360
abnormal neuroanatomy, with Scer\GAL4shot-OK307
abnormal neuroanatomy | adult stage
abnormal neuroanatomy | adult stage, with Scer\GAL4Pdf.PU
abnormal neuroanatomy | adult stage | female | somatic clone
abnormal neuroanatomy | adult stage | male, with Scer\GAL4Poxn.14
abnormal neuroanatomy | adult stage | somatic clone, with Scer\GAL4Pdf.PU
abnormal neuroanatomy | embryonic stage
abnormal neuroanatomy | somatic clone, with Scer\GAL4109(2)80
abnormal size | adult stage
abnormal size | adult stage, with Scer\GAL4Pdf.PU
abnormal size | adult stage | somatic clone, with Scer\GAL4Pdf.PU
Phenotype manifest in
Allele
abdominal basiconical sensillum dbd & embryo & nerve terminal, with Scer\GAL412.1
adult mushroom body gamma-lobe
adult s-LNv neuron | adult stage
adult s-LNv neuron | adult stage | somatic clone, with Scer\GAL4Pdf.PU
antennal lobe glomerulus | ectopic, with Scer\GAL4lz-gal4
antennal lobe glomerulus | ectopic | somatic clone
antennal lobe glomerulus DM2 | somatic clone
axon | adult stage
axon | adult stage | somatic clone, with Scer\GAL4Pdf.PU
chordotonal organ & embryo & nerve terminal
connective | embryonic stage
dendritic arborizing neuron, with Scer\GAL4109(2)80
dendritic arborizing neuron | somatic clone, with Scer\GAL4109(2)80
ellipsoid body
embryonic longitudinal glial cell
embryonic ventral nerve cord
eye, with Scer\GAL4GMR.PF
eye photoreceptor cell | somatic clone
germline cell | embryonic stage (with Df(2L)Exel7006)
giant fiber neuron, with Scer\GAL4c17
giant fiber neuron, with Scer\GAL4shot-OK307
gonad | embryonic stage (with Df(2L)Exel7006)
intermediate longitudinal fascicle
intermediate longitudinal fascicle, with Scer\GAL412.1, robo31
intermediate longitudinal fascicle, with Scer\GAL412.1, robo3UAS.cSa
larval EW neuron, with Scer\GAL4eg-Mz360
larval longitudinal connective
larval longitudinal connective, with Scer\GAL4elav.PLu
larval neuron, with Scer\GAL4ap-md544
larval thoracic lateral multidendritic neuron ldaA | somatic clone, with Scer\GAL4109(2)80
larval ventral nerve cord commissure, with Scer\GAL4elav.PLu
medial lobe of adult mushroom body
medial longitudinal fascicle
medial longitudinal fascicle, with Scer\GAL412.1, robo31
medial longitudinal fascicle, with Scer\GAL412.1, robo3UAS.cSa
medulla
medulla | somatic clone
neurite | adult stage | ectopic | female | somatic clone
olfactory neuron & antennal lobe, with Scer\GAL4lz-gal4
olfactory neuron & antennal lobe, with Scer\GAL4SG18.1
olfactory neuron & antennal lobe | somatic clone
photoreceptor cell R8
photoreceptor cell R8 | somatic clone, with Scer\GAL4sens.PB
prothoracic leg taste bristle chemosensory neuron | male, with Scer\GAL4Poxn.14
vertical lobe of adult mushroom body
VL fascicle, with Scer\GAL4109(2)80
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (115)
Hsap\ROBO1
9 of 14
Yes
Yes
4  
Hsap\ROBO3
9 of 14
Yes
Yes
Hsap\ROBO2
8 of 14
No
No
Hsap\HMCN1
2 of 14
No
No
Hsap\HMCN2
2 of 14
No
No
Hsap\IGDCC3
2 of 14
No
No
Hsap\OBSL1
2 of 14
No
No
Hsap\ROBO4
2 of 14
No
Yes
Hsap\ALK
1 of 14
No
No
16  
Hsap\BOC
1 of 14
No
No
2  
Hsap\CADM1
1 of 14
No
No
Hsap\CADM2
1 of 14
No
No
Hsap\CADM3
1 of 14
No
No
Hsap\CADM4
1 of 14
No
No
Hsap\CD22
1 of 14
No
No
Hsap\CD200
1 of 14
No
No
Hsap\CD226
1 of 14
No
Yes
Hsap\CDON
1 of 14
No
No
Hsap\CEACAM5
1 of 14
No
No
Hsap\CEACAM6
1 of 14
No
No
Hsap\CEACAM20
1 of 14
No
Yes
Hsap\CHL1
1 of 14
No
No
Hsap\CNTN1
1 of 14
No
No
Hsap\CNTN2
1 of 14
No
No
Hsap\CNTN3
1 of 14
No
No
Hsap\CNTN4
1 of 14
No
No
Hsap\CNTN5
1 of 14
No
No
Hsap\CNTN6
1 of 14
No
No
Hsap\DCC
1 of 14
No
No
4  
Hsap\DSCAM
1 of 14
No
No
3  
Hsap\DSCAML1
1 of 14
No
No
2  
Hsap\EPHA3
1 of 14
No
No
Hsap\EPHA5
1 of 14
No
No
Hsap\EPHB3
1 of 14
No
No
Hsap\F11R
1 of 14
No
Yes
Hsap\FCGR2A
1 of 14
No
Yes
Hsap\FCGR2C
1 of 14
No
Yes
Hsap\FCRL1
1 of 14
No
Yes
Hsap\FCRL2
1 of 14
No
Yes
Hsap\FCRL3
1 of 14
No
Yes
Hsap\FCRL4
1 of 14
No
Yes
Hsap\FCRL5
1 of 14
No
Yes
Hsap\FCRL6
1 of 14
No
Yes
Hsap\FGFR1
1 of 14
No
No
Hsap\FGFR2
1 of 14
No
No
Hsap\FGFR3
1 of 14
No
No
Hsap\FGFRL1
1 of 14
No
No
Hsap\FLT1
1 of 14
No
No
Hsap\FLT4
1 of 14
No
No
Hsap\HSPG2
1 of 14
No
No
Hsap\IGDCC4
1 of 14
No
No
Hsap\IGLON5
1 of 14
No
No
Hsap\IGSF9B
1 of 14
No
No
Hsap\IGSF9
1 of 14
No
No
2  
Hsap\IGSF10
1 of 14
No
No
Hsap\JAM2
1 of 14
No
Yes
Hsap\KDR
1 of 14
No
No
2  
Hsap\KIRREL1
1 of 14
No
No
Hsap\KIRREL2
1 of 14
No
No
Hsap\KIRREL3
1 of 14
No
No
Hsap\L1CAM
1 of 14
No
No
11  
Hsap\LRIG1
1 of 14
No
No
Hsap\LRIG2
1 of 14
No
No
Hsap\LRIG3
1 of 14
No
No
Hsap\LSAMP
1 of 14
No
No
Hsap\LTK
1 of 14
No
No
Hsap\MCAM
1 of 14
No
Yes
Hsap\MUSK
1 of 14
No
No
1  
Hsap\MXRA5
1 of 14
No
No
Hsap\NCAM1
1 of 14
No
No
4  
Hsap\NCAM2
1 of 14
No
No
Hsap\NECTIN1
1 of 14
No
No
Hsap\NECTIN2
1 of 14
No
No
Hsap\NECTIN3
1 of 14
No
No
Hsap\NECTIN4
1 of 14
No
No
Hsap\NEGR1
1 of 14
No
No
1  
Hsap\NEO1
1 of 14
No
No
Hsap\NFASC
1 of 14
No
No
Hsap\NPHS1
1 of 14
No
No
10  
Hsap\NRCAM
1 of 14
No
No
Hsap\NTM
1 of 14
No
No
Hsap\OBSCN
1 of 14
No
No
Hsap\OPCML
1 of 14
No
No
Hsap\PALLD
1 of 14
No
No
Hsap\PDGFRA
1 of 14
No
No
Hsap\PDGFRB
1 of 14
No
No
2  
Hsap\PRTG
1 of 14
No
No
Hsap\PSG2
1 of 14
No
No
Hsap\PSG4
1 of 14
No
Yes
Hsap\PSG5
1 of 14
No
No
Hsap\PSG7
1 of 14
No
Yes
Hsap\PSG11
1 of 14
No
No
Hsap\PTK2B
1 of 14
No
No
1  
Hsap\PTK2
1 of 14
No
No
Hsap\PTK6
1 of 14
No
No
Hsap\PTK7
1 of 14
No
No
1  
Hsap\PTPRF
1 of 14
No
No
2  
Hsap\PTPRS
1 of 14
No
No
Hsap\PVR
1 of 14
No
No
1  
Hsap\PXDN
1 of 14
No
No
3  
Hsap\PXDNL
1 of 14
No
No
1  
Hsap\RET
1 of 14
No
No
1  
Hsap\SDK1
1 of 14
No
No
Hsap\SDK2
1 of 14
No
No
1  
Hsap\SEMA5A
1 of 14
No
No
Hsap\SIGLEC1
1 of 14
No
No
Hsap\SIGLEC5
1 of 14
No
No
Hsap\SSPOP
1 of 14
No
No
Hsap\TTN
1 of 14
No
No
Hsap\UNC5A
1 of 14
No
No
Hsap\UNC5B
1 of 14
No
No
Hsap\UNC5C
1 of 14
No
No
Hsap\UNC5D
1 of 14
No
No
Hsap\VSIG1
1 of 14
No
Yes
Hsap\VSIG2
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (48)
Rnor\Robo1
9 of 14
Yes
Yes
Rnor\Robo3
8 of 14
No
No
Rnor\Robo2
7 of 14
No
No
Rnor\Robo4
2 of 14
No
Yes
Rnor\Boc
1 of 14
No
No
Rnor\Cadm1
1 of 14
No
No
Rnor\Cadm2
1 of 14
No
No
Rnor\Cadm3
1 of 14
No
No
Rnor\Cd200
1 of 14
No
No
Rnor\Cdon
1 of 14
No
No
Rnor\Chl1
1 of 14
No
No
Rnor\Cntn3
1 of 14
No
No
Rnor\Cntn4
1 of 14
No
No
Rnor\Cntn5
1 of 14
No
No
Rnor\Cntn6
1 of 14
No
No
Rnor\Dcc
1 of 14
No
No
Rnor\Dscaml1
1 of 14
No
No
Rnor\Dscam
1 of 14
No
No
Rnor\Hmcn1
1 of 14
No
No
Rnor\Igdcc3
1 of 14
No
No
Rnor\Igdcc4
1 of 14
No
No
Rnor\Iglon5
1 of 14
No
No
Rnor\Igsf10
1 of 14
No
No
Rnor\Kirrel3
1 of 14
No
No
Rnor\L1cam
1 of 14
No
No
Rnor\LOC685716
1 of 14
No
Yes
Rnor\LOC685767
1 of 14
No
Yes
Rnor\Lsamp
1 of 14
No
No
Rnor\Nectin1
1 of 14
No
No
Rnor\Nectin2
1 of 14
No
No
Rnor\Nectin3
1 of 14
No
No
Rnor\Nectin4
1 of 14
No
No
Rnor\Negr1
1 of 14
No
No
Rnor\Neo1
1 of 14
No
No
Rnor\Nrcam
1 of 14
No
No
2  
Rnor\Ntm
1 of 14
No
No
Rnor\Obsl1
1 of 14
No
No
Rnor\Opcml
1 of 14
No
No
Rnor\Prtg
1 of 14
No
Yes
Rnor\Ptprf
1 of 14
No
No
Rnor\Ptprs
1 of 14
No
No
Rnor\Pvr
1 of 14
No
Yes
Rnor\Pxdn
1 of 14
No
No
Rnor\Sdk2
1 of 14
No
No
Rnor\Unc5a
1 of 14
No
No
Rnor\Unc5b
1 of 14
No
No
Rnor\Unc5c
1 of 14
No
No
Rnor\Unc5d
1 of 14
No
No
Mus musculus (laboratory mouse) (49)
Mmus\Robo1
9 of 14
Yes
Yes
Mmus\Robo2
8 of 14
No
No
Mmus\Robo3
8 of 14
No
No
Mmus\Igdcc3
2 of 14
No
No
Mmus\Boc
1 of 14
No
No
Mmus\Cadm1
1 of 14
No
No
Mmus\Cadm2
1 of 14
No
No
Mmus\Cadm3
1 of 14
No
No
Mmus\Cd200
1 of 14
No
No
Mmus\Cdon
1 of 14
No
No
Mmus\Cntn3
1 of 14
No
No
Mmus\Cntn4
1 of 14
No
No
Mmus\Cntn5
1 of 14
No
No
Mmus\Cntn6
1 of 14
No
No
Mmus\Dcc
1 of 14
No
No
Mmus\Dscaml1
1 of 14
No
No
Mmus\Dscam
1 of 14
No
No
1  
Mmus\Gm609
1 of 14
No
Yes
Mmus\Gm17783
1 of 14
No
Yes
Mmus\Hmcn1
1 of 14
No
No
Mmus\Hmcn2
1 of 14
No
No
Mmus\Igdcc4
1 of 14
No
No
Mmus\Iglon5
1 of 14
No
No
Mmus\Kirrel3
1 of 14
No
No
1  
Mmus\L1cam
1 of 14
No
No
1  
Mmus\Lsamp
1 of 14
No
No
Mmus\Nectin1
1 of 14
No
No
Mmus\Nectin2
1 of 14
No
No
Mmus\Nectin3
1 of 14
No
No
Mmus\Nectin4
1 of 14
No
No
Mmus\Negr1
1 of 14
No
No
Mmus\Neo1
1 of 14
No
No
Mmus\Nrcam
1 of 14
No
No
Mmus\Ntm
1 of 14
No
No
Mmus\Obsl1
1 of 14
No
No
Mmus\Opcml
1 of 14
No
No
Mmus\Prtg
1 of 14
No
No
Mmus\Ptprf
1 of 14
No
No
Mmus\Ptprs
1 of 14
No
No
Mmus\Pvr
1 of 14
No
No
Mmus\Pxdn
1 of 14
No
No
Mmus\Robo4
1 of 14
No
No
Mmus\Sdk1
1 of 14
No
No
Mmus\Sdk2
1 of 14
No
No
Mmus\Ttn
1 of 14
No
No
Mmus\Unc5a
1 of 14
No
No
Mmus\Unc5b
1 of 14
No
No
Mmus\Unc5c
1 of 14
No
No
Mmus\Unc5d
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (46)
Xtro\robo1
5 of 13
Yes
Yes
Xtro\robo3
5 of 13
Yes
No
Xtro\robo2
4 of 13
No
No
Xtro\igdcc3
2 of 13
No
Yes
Xtro\npffr1.1
2 of 13
No
No
Xtro\prtg
2 of 13
No
No
Xtro\adamtsl1
1 of 13
No
No
Xtro\bin2
1 of 13
No
No
Xtro\cadm2
1 of 13
No
No
Xtro\cd22
1 of 13
No
No
Xtro\col20a1
1 of 13
No
No
Xtro\dcc
1 of 13
No
No
Xtro\dscam
1 of 13
No
No
Xtro\epha6
1 of 13
No
No
Xtro\epha7
1 of 13
No
No
Xtro\fgfr1op2
1 of 13
No
No
Xtro\fgfr3
1 of 13
No
No
Xtro\hmcn1
1 of 13
No
No
Xtro\hmcn2
1 of 13
No
No
Xtro\iglon5
1 of 13
No
No
Xtro\igsf9b
1 of 13
No
No
Xtro\igsf10
1 of 13
No
No
Xtro\jam3
1 of 13
No
Yes
Xtro\kirrel1
1 of 13
No
No
Xtro\LOC108648322
1 of 13
No
No
Xtro\lrfn5
1 of 13
No
No
Xtro\lrig1
1 of 13
No
No
Xtro\lrig2
1 of 13
No
No
Xtro\lrig3
1 of 13
No
No
Xtro\ltk
1 of 13
No
No
Xtro\mxra5
1 of 13
No
No
Xtro\ncam1
1 of 13
No
No
Xtro\ncam2
1 of 13
No
No
Xtro\nectin1l1
1 of 13
No
Yes
Xtro\nectin1
1 of 13
No
Yes
Xtro\nectin4
1 of 13
No
Yes
Xtro\nrcam
1 of 13
No
No
Xtro\obsl1
1 of 13
No
Yes
Xtro\pecam1
1 of 13
No
Yes
Xtro\pxdn
1 of 13
No
No
Xtro\robo4
1 of 13
No
Yes
Xtro\slc35g1
1 of 13
No
No
Xtro\spc25
1 of 13
No
Yes
Xtro\tie1
1 of 13
No
No
Xtro\tyro3
1 of 13
No
Yes
Xtro\u2af2
1 of 13
No
No
Danio rerio (Zebrafish) (77)
Drer\robo3
9 of 14
Yes
Yes
Drer\robo1
8 of 14
No
No
Drer\robo2
7 of 14
No
No
Drer\zgc:77784
7 of 14
No
No
Drer\robo4
3 of 14
No
Yes
Drer\bcam
1 of 14
No
No
Drer\boc
1 of 14
No
No
Drer\cadm1a
1 of 14
No
No
Drer\cadm1b
1 of 14
No
No
Drer\cadm2a
1 of 14
No
No
Drer\cadm2b
1 of 14
No
No
Drer\cadm3
1 of 14
No
No
Drer\cd4-2.2
1 of 14
No
Yes
Drer\cdon
1 of 14
No
No
Drer\ceacam1
1 of 14
No
No
Drer\cntn1b
1 of 14
No
No
Drer\cntn3a.1
1 of 14
No
No
Drer\cntn3b
1 of 14
No
No
Drer\cntn4
1 of 14
No
No
Drer\cntn5
1 of 14
No
No
Drer\dcc
1 of 14
No
No
Drer\dscama
1 of 14
No
No
Drer\dscamb
1 of 14
No
No
Drer\hmcn1
1 of 14
No
No
Drer\hmcn2
1 of 14
No
No
Drer\igdcc3
1 of 14
No
No
Drer\igdcc4
1 of 14
No
No
Drer\iglon5
1 of 14
No
No
Drer\kirrel1b
1 of 14
No
No
Drer\kirrel3a
1 of 14
No
No
Drer\kirrel3b
1 of 14
No
No
Drer\kirrel3l
1 of 14
No
No
Drer\LOC100332721
1 of 14
No
No
Drer\LOC101883325
1 of 14
No
No
Drer\mcamb
1 of 14
No
No
Drer\ncam1a
1 of 14
No
No
Drer\ncam2
1 of 14
No
No
Drer\nectin1a
1 of 14
No
No
Drer\nectin1b
1 of 14
No
Yes
Drer\nectin3a
1 of 14
No
No
Drer\nectin3b
1 of 14
No
No
Drer\nectin4b
1 of 14
No
Yes
Drer\negr1
1 of 14
No
No
Drer\neo1a
1 of 14
No
No
Drer\neo1b
1 of 14
No
No
Drer\nrcama
1 of 14
No
No
Drer\ntm
1 of 14
No
No
Drer\obsl1a
1 of 14
No
No
Drer\obsl1b
1 of 14
No
No
Drer\opcml
1 of 14
No
No
Drer\prtga
1 of 14
No
No
Drer\prtgb
1 of 14
No
No
Drer\ptprdb
1 of 14
No
No
Drer\ptprfa
1 of 14
No
No
Drer\ptprfb
1 of 14
No
No
Drer\ptprsa
1 of 14
No
No
Drer\pvrl2l
1 of 14
No
No
Drer\pxdn
1 of 14
No
No
Drer\sc:d189
1 of 14
No
Yes
Drer\sdk1a
1 of 14
No
No
Drer\sdk1b
1 of 14
No
No
Drer\sdk2a
1 of 14
No
No
Drer\sdk2b
1 of 14
No
No
Drer\si:ch73-22o12.1
1 of 14
No
No
Drer\si:ch211-57n23.4
1 of 14
No
No
Drer\si:ch211-141e20.2
1 of 14
No
No
Drer\si:dkey-31e10.1
1 of 14
No
Yes
Drer\si:dkey-31e10.5
1 of 14
No
Yes
Drer\unc5a
1 of 14
No
No
Drer\unc5b
1 of 14
No
No
Drer\unc5ca
1 of 14
No
No
Drer\unc5cb
1 of 14
No
No
Drer\unc5da
1 of 14
No
No
Drer\unc5db
1 of 14
No
No
Drer\zgc:112965
1 of 14
No
Yes
Drer\zgc:113337
1 of 14
No
Yes
Drer\zgc:172122
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (32)
Cele\sax-3
11 of 14
Yes
Yes
Cele\egl-15
1 of 14
No
No
Cele\F21C10.7
1 of 14
No
No
Cele\him-4
1 of 14
No
No
Cele\igcm-1
1 of 14
No
No
Cele\igcm-2
1 of 14
No
No
Cele\igcm-4
1 of 14
No
No
Cele\lad-2
1 of 14
No
No
Cele\let-805
1 of 14
No
No
Cele\mig-21
1 of 14
No
Yes
Cele\ncam-1
1 of 14
No
No
Cele\oig-1
1 of 14
No
No
Cele\oig-4
1 of 14
No
No
Cele\pxn-1
1 of 14
No
No
Cele\rig-5
1 of 14
No
No
Cele\sma-10
1 of 14
No
No
Cele\syg-1
1 of 14
No
No
Cele\syg-2
1 of 14
No
No
Cele\T01G5.1
1 of 14
No
No
Cele\trk-1
1 of 14
No
No
Cele\ttn-1
1 of 14
No
No
Cele\unc-5
1 of 14
No
No
Cele\unc-40
1 of 14
No
No
Cele\unc-89
1 of 14
No
No
Cele\ver-1
1 of 14
No
No
Cele\wrk-1
1 of 14
No
No
Cele\zig-2
1 of 14
No
No
Cele\zig-3
1 of 14
No
No
Cele\zig-4
1 of 14
No
No
Cele\zig-5
1 of 14
No
Yes
Cele\zig-6
1 of 14
No
Yes
Cele\zig-10
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (69)
Agam\AgaP_AGAP010242
11 of 12
Yes
Yes
Agam\AgaP_AGAP010245
6 of 12
No
No
Agam\AgaP_AGAP010969
5 of 12
No
No
Agam\AgaP_AGAP010970
5 of 12
No
No
Agam\AgaP_AGAP012226
3 of 12
No
Yes
Agam\AgaP_AGAP000217
1 of 12
No
No
Agam\AgaP_AGAP000218
1 of 12
No
No
Agam\AgaP_AGAP000659
1 of 12
No
No
Agam\AgaP_AGAP000720
1 of 12
No
No
Agam\AgaP_AGAP000863
1 of 12
No
No
Agam\AgaP_AGAP001410
1 of 12
No
No
Agam\AgaP_AGAP001504
1 of 12
No
No
Agam\AgaP_AGAP001633
1 of 12
No
No
Agam\AgaP_AGAP001824
1 of 12
No
No
Agam\AgaP_AGAP002040
1 of 12
No
No
Agam\AgaP_AGAP002104
1 of 12
No
No
Agam\AgaP_AGAP002268
1 of 12
No
No
Agam\AgaP_AGAP002325
1 of 12
No
No
Agam\AgaP_AGAP002336
1 of 12
No
No
Agam\AgaP_AGAP002628
1 of 12
No
No
Agam\AgaP_AGAP002802
1 of 12
No
No
Agam\AgaP_AGAP003108
1 of 12
No
No
Agam\AgaP_AGAP003235
1 of 12
No
No
Agam\AgaP_AGAP003305
1 of 12
No
No
Agam\AgaP_AGAP003365
1 of 12
No
No
Agam\AgaP_AGAP003656
1 of 12
No
No
Agam\AgaP_AGAP003849
1 of 12
No
No
Agam\AgaP_AGAP004108
1 of 12
No
No
Agam\AgaP_AGAP004230
1 of 12
No
No
Agam\AgaP_AGAP004902
1 of 12
No
No
Agam\AgaP_AGAP004915
1 of 12
No
No
Agam\AgaP_AGAP005219
1 of 12
No
No
Agam\AgaP_AGAP005471
1 of 12
No
No
Agam\AgaP_AGAP005849
1 of 12
No
No
Agam\AgaP_AGAP006083
1 of 12
No
No
Agam\AgaP_AGAP007091
1 of 12
No
No
Agam\AgaP_AGAP007092
1 of 12
No
No
Agam\AgaP_AGAP007500
1 of 12
No
No
Agam\AgaP_AGAP007563
1 of 12
No
No
Agam\AgaP_AGAP007928
1 of 12
No
No
Agam\AgaP_AGAP008408
1 of 12
No
No
Agam\AgaP_AGAP008778
1 of 12
No
No
Agam\AgaP_AGAP008813
1 of 12
No
No
Agam\AgaP_AGAP008943
1 of 12
No
No
Agam\AgaP_AGAP009061
1 of 12
No
No
Agam\AgaP_AGAP009063
1 of 12
No
No
Agam\AgaP_AGAP009138
1 of 12
No
No
Agam\AgaP_AGAP009596
1 of 12
No
No
Agam\AgaP_AGAP009683
1 of 12
No
No
Agam\AgaP_AGAP009688
1 of 12
No
No
Agam\AgaP_AGAP009965
1 of 12
No
No
Agam\AgaP_AGAP010184
1 of 12
No
No
Agam\AgaP_AGAP010185
1 of 12
No
No
Agam\AgaP_AGAP010186
1 of 12
No
No
Agam\AgaP_AGAP010221
1 of 12
No
No
Agam\AgaP_AGAP010222
1 of 12
No
No
Agam\AgaP_AGAP010422
1 of 12
No
No
Agam\AgaP_AGAP010742
1 of 12
No
No
Agam\AgaP_AGAP010746
1 of 12
No
No
Agam\AgaP_AGAP010823
1 of 12
No
No
Agam\AgaP_AGAP010884
1 of 12
No
No
Agam\AgaP_AGAP011094
1 of 12
No
No
Agam\AgaP_AGAP011095
1 of 12
No
No
Agam\AgaP_AGAP011194
1 of 12
No
No
Agam\AgaP_AGAP011195
1 of 12
No
No
Agam\AgaP_AGAP011700
1 of 12
No
No
Agam\AgaP_AGAP012059
1 of 12
No
No
Agam\HPX4
1 of 12
No
No
Agam\IGL1
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\ALE2
1 of 13
Yes
No
Atha\AT3G50730
1 of 13
Yes
No
Atha\AT5G58950
1 of 13
Yes
No
Atha\CTR1
1 of 13
Yes
No
Atha\LYK3
1 of 13
Yes
Yes
Atha\WAK5
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:robo3. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (66)
robo2
8 of 13
robo1
7 of 13
boi
2 of 13
Cont
2 of 13
Dscam3
2 of 13
Fas2
2 of 13
ihog
2 of 13
plum
2 of 13
tutl
2 of 13
Ack
1 of 13
Alk
1 of 13
Ama
1 of 13
bdl
1 of 13
btl
1 of 13
CG6867
1 of 13
CG7166
1 of 13
CG7607
1 of 13
CG13506
1 of 13
CG17528
1 of 13
CG34353
1 of 13
CG45263
1 of 13
DIP-α
1 of 13
DIP-β
1 of 13
DIP-δ
1 of 13
DIP-ε
1 of 13
DIP-η
1 of 13
DIP-ι
1 of 13
DIP-κ
1 of 13
DIP-λ
1 of 13
DIP-θ
1 of 13
DIP-ζ
1 of 13
Dscam1
1 of 13
Dscam2
1 of 13
Dscam4
1 of 13
ed
1 of 13
fipi
1 of 13
fra
1 of 13
fred
1 of 13
hbs
1 of 13
htl
1 of 13
kirre
1 of 13
klg
1 of 13
Lac
1 of 13
Lar
1 of 13
nkt
1 of 13
Nrg
1 of 13
Obsc
1 of 13
Pvr
1 of 13
Pxn
1 of 13
Ret
1 of 13
rst
1 of 13
sdk
1 of 13
side-III
1 of 13
side-II
1 of 13
side-IV
1 of 13
side-VIII
1 of 13
side-VII
1 of 13
side-VI
1 of 13
sls
1 of 13
sns
1 of 13
Strn-Mlck
1 of 13
tei
1 of 13
trol
1 of 13
unc-5
1 of 13
wrapper
1 of 13
zormin
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ROBO1; roundabout guidance receptor 1
    9 of 14
    ROUNDABOUT GUIDANCE RECEPTOR 1; ROBO1
     
    ROBO3; roundabout guidance receptor 3
    9 of 14
    608630
      ROBO2; roundabout guidance receptor 2
      8 of 14
      602431
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      robo1|robo3
      enhanceable
      Abl
      (Wills et al., 2002)
      robo3
      suppressible
      Ptp69D
      (Oliva et al., 2016)
      robo3
      enhanceable
      robo1
      (Evans and Bashaw, 2010)
      robo3
      enhanceable
      sli
      (Zlatic et al., 2003)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Abl
      enhanceable
      robo3
      (Wills et al., 2002)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2L
      Recombination map
      2-2
      Cytogenetic map
      21F3-21F4
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      21F3-21F4
      Limits computationally determined from genome sequence between P{PZ}l(2)1068510685&P{lacW}Tango14k00619 and P{lacW}RFeSPk11704
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      22A-22A
      (Rajagopalan, 2000.10.12)
      Experimentally Determined Recombination Data
      Location

      2-2

      (FlyBase, 2016)

      2-2.0

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (96)
      Genomic Clones (47)
      cDNA Clones (5)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        monoclonal

        (Jhaveri et al., 2004)
        Commercially Available Antibodies
         
        Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            The lateral positioning of longitudinal axon pathways in the embryo relies primarily on differences in robo gene regulation, not on distinct combinations of the three robo proteins (robo, lea and robo3) as previously thought. However, the unique structural features of robo are required to prevent midline crossing and the unique structural features of lea are required to promote midline crossing.

            (Spitzweck et al., 2010)

            robo3 expression is one of several properties characteristic of ch neurons that depend on ato expression.

            (Zlatic et al., 2003)

            Arbor position in the mediolateral axis is determined in a binary fashion by the expression (ch neurons) or not (md neurons) of the robo3 sli receptor.

            (Zlatic et al., 2003)

            Ectopic expression of robo3 in md neurons switches their terminal arbor from a medial to an intermediate fascicle.

            (Zlatic et al., 2003)

            robo3 is present only on the lateral 2/3 longitudinal tracts in the CNS.

            (Dickson et al., 2000)

            low levels of lea or robo and robo3 have both distinct and overlapping functions in controlling pathway choices within the central nervous system.

            (Rajagopalan et al., 2000)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: robo3 CG14345 CG5423

            (FlyBase, 1996-)
            Additional comments

            Source for merge of robo3 CG14345 CG5423 was sequence comparison ( date:001223 ).

            (FlyBase, 1996-)
            Nomenclature History
            Source for database identify of
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (14)
            Reported As
            Symbol Synonym
            CG14345
            (Spellman and Rubin, 2002)
            CG5423
            (National Institute of Genetics Fly Stocks, 2022-, Meadows, 2017.1.11, Ni et al., 2010.12.1, Perkins et al., 2009, Metaxakis et al., 2005, Spellman and Rubin, 2002)
            CT17158
            (Hynes and Zhao, 2000)
            ROBO3
            (Katsuki et al., 2009)
            Robo
            (Morin-Poulard et al., 2021, Lan et al., 2020, Muralidharan, 2020)
            Robo 3
            (Zlatic et al., 2009)
            Robo-3
            (Kuzin et al., 2005, Brummendorf and Lemmon, 2001, Selby, 2000.11.1)
            Robo3
            (Sanhueza et al., 2025, Fischer et al., 2024, Sullivan and Bashaw, 2023, Evans, 2017, Suzuki and Sato, 2017, Evans et al., 2015, Ozkan et al., 2013, Catalán et al., 2012, Wayburn and Volk, 2009, Evans et al., 2008, Spitzweck et al., 2007, Chilton, 2006, Santiago-Martinez et al., 2006, Howitt et al., 2004, Patel and Van Vactor, 2002, Furrer and Chiba, 2001, Dickson et al., 2000)
            dRobo-3
            (Brose and Tessier-Lavigne, 2000)
            robo
            (Araki et al., 2020, Jalvingh et al., 2014)
            robo-3
            (Mitchell, 2018)
            robo3
            (Carranza et al., 2025, Li et al., 2025, Pollex et al., 2024, Beaver et al., 2022, González-Ramírez et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Velten et al., 2022, Xie et al., 2021, Kitatani et al., 2020, Donato et al., 2019, FlyBase Genome Annotators, 2019-, Meltzer et al., 2019, Gene Disruption Project members, 2018-, Manavalan et al., 2017, Dubois et al., 2016, Evans, 2016, Friedrich et al., 2016, Ito et al., 2016, Oliva et al., 2016, Raza and Jacobs, 2016, Shen et al., 2016, Gene Disruption Project members, 2015-, Kern et al., 2015, Ashwal-Fluss et al., 2014, Bashaw et al., 2014.11.4, Biteau and Jasper, 2014, Santiago et al., 2014, Wolfram et al., 2014, Ozkan et al., 2013, Ozkan et al., 2013, Evans and Bashaw, 2012, Pappu et al., 2011, Shin and Diantonio, 2011, Smart et al., 2011, Weyers et al., 2011, Evans and Bashaw, 2010, Evans and Bashaw, 2010, Mellert et al., 2010, Spitzweck et al., 2010, Hazelett et al., 2009, Jiang et al., 2009, Bhat et al., 2007, Grueber et al., 2007, Magalhaes et al., 2007, Merianda et al., 2005, Nicolas and Preat, 2005)
            Name Synonyms
            Robo
            (Luo et al., 2020)
            Roundabout 3
            (Pappu et al., 2011)
            robo3
            roundabout 3
            (Friedrich et al., 2016, Bashaw et al., 2014.11.4, Santiago et al., 2014)
            Secondary FlyBase IDs
            • FBgn0031328
            • FBgn0031330
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 45 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Flygut - An atlas of the Drosophila adult midgut
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            References (163)