FlyBase Gene Report: Dmel\sls

posterior midgut primordium

(Katti et al., 2017)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11

mesoderm

(Hakeda et al., 2000)

(Kolmerer et al., 2000)

anterior midgut primordium

(Kolmerer et al., 2000)

embryonic stage 11 -- 17

embryonic/larval salivary gland

(Kolmerer et al., 2000)

visceral trunk mesoderm

(Hakeda et al., 2000, Machado et al., 1998)

somatic trunk mesoderm

(Hakeda et al., 2000, Kolmerer et al., 2000, Machado et al., 1998)

dorsal pharyngeal muscle cell

(Kolmerer et al., 2000)

embryonic stage 13 -- 16

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

larval muscle system

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

embryonic/larval posterior spiracle

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

(Fisher et al., 2012)

(Machado et al., 1998)

embryonic stage 13 -- 17

larval visceral muscle cell

(Hakeda et al., 2000, Kolmerer et al., 2000, Machado et al., 1998)

(Hakeda et al., 2000, Kolmerer et al., 2000, Machado et al., 1998)

embryonic stage 14 -- 17

first instar larval stage

(Hakeda et al., 2000)

embryonic stage 16

muscle attachment site

(Hakeda et al., 2000)

larval muscle system

(Hakeda et al., 2000)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval epidermis

(Nakaoka et al., 2017)

Additional Descriptive Data

The 18kb Ket transcript is a minor species observed on northern blots.

(Hakeda et al., 2000)

Ket transcripts are first expressed at stage 11 in the mesoderm. They are expressed in most if not all muscles until the third instar larval stage. At stage 14, they are expressed in nearly all somatic, visceral, and pharyngeal muscles. Later they are expressed in muscle attachment sites.

(Hakeda et al., 2000)

Ket transcripts are first detected in early stage 11 embryos. Expression is observed mainly in the hindgut and posterior midgut invagination. By late stage 11, expression is observed throughout the mesoderm and can be seen in the progenitors to the pharyngeal muscles and salivary glands. By stage 12,13, the mesodermal pattern has resolved into a parasegmental pattern. By stage 13,14, expression is present in both somatic and visceral mesoderm.

(Kolmerer et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

larval visceral muscle cell

(Hakeda et al., 2000)

muscle attachment site

(Hakeda et al., 2000)

(Hakeda et al., 2000)

embryonic stage 12 -- 17

myotube

• plasma membrane | restricted

(Menon and Chia, 2001)

fusion competent cell

• plasma membrane

(Menon and Chia, 2001)

muscle founder cell

• cytoplasm

(Menon and Chia, 2001)

embryonic stage 13 -- 16

(Machado et al., 1998)

embryonic stage 13 -- 17

larval visceral muscle cell

(Machado et al., 1998)

(Machado et al., 1998)

larval stage

muscle cell

• Z disc

(Hakeda et al., 2000)

pupal stage P6

indirect flight muscle cell | punctate

Comment: 30 hr APF

(Ayme-Southgate et al., 2004)

pupal stage P7 -- pharate adult stage P8

indirect flight muscle cell | precursor

• myofibril

Comment: start at 36 hr APF

(Ayme-Southgate et al., 2004)

pharate adult stage P8 -- P15

indirect flight muscle cell | precursor

• Z disc

Comment: 48 hr APF

(Ayme-Southgate et al., 2004)

muscle cell

• Z disc

(Hakeda et al., 2000, Machado et al., 1998, Lakey et al., 1993)

peritoneal sheath muscle cell

• Z disc

(Burkart et al., 2007)

adult stage | female

(Hudson et al., 2008)

ovarian sheath muscle cell

(Hudson et al., 2008)

common oviduct circular muscle cell

(Hudson et al., 2008)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010, Dorus et al., 2006)

adult heart

(Cammarato et al., 2011)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

View exonic expression by developmental stage for Dmel\sls

(Kolmerer et al., 2000)

Additional Descriptive Data

sls protein can be detected in scattered aggregates dispersed in the cytoplasm of muscle cell precursors as early at 30 hrs APF. By 48 hours sls, along with other myofibrillar proteins, have organized into Z-bands.

(Ayme-Southgate et al., 2004)

The protein is enriched at the membrane of fusion competent cells and primarily cytoplasmic in founder cells in the developing muscle system. In myotubes sls protein islocated near the points of contact with myoblasts.

(Menon and Chia, 2001)

Ket protein localizes to the nucleus during interphase and to the chromosomes during mitosis.

(Machado et al., 1998, Lakey et al., 1993)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in condensed nuclear chromosome

inferred from direct assay

(Machado et al., 1998)

located_in I band

inferred from direct assay

(Burkart et al., 2007)

located_in sarcomere

inferred from direct assay

(Machado et al., 1998)

inferred from direct assay

(Hakeda et al., 2000)

located_in striated muscle myosin thick filament

inferred from direct assay

(Burkart et al., 2007)

located_in Z disc

inferred from direct assay

(González-Morales et al., 2017, Hudson et al., 2008, Burkart et al., 2007, Kreiskother et al., 2006, Bullard et al., 2005, Ayme-Southgate et al., 2004)

inferred from high throughput direct assay

(Sarov et al., 2016)

inferred from direct assay

(Katzemich et al., 2015, van Straaten et al., 1999)

inferred from direct assay

(Machado et al., 1998)

inferred from mutant phenotype

(Kolmerer et al., 2000)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\sls in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by tissue for Dmel\sls

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0086906

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44013/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086906

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086906

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1915

Flygut - An atlas of the Drosophila adult midgut

FBgn0086906

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\sls

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 69 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of sls

Transgenic constructs containing regulatory region of sls

Aberrations (Deficiencies and Duplications) ( 157 )

Inferred from experimentation ( 157 )

Gene disrupted in

Df(3L)Aprt-1

(Wang et al., 1994)

Df(3L)Aprt-3

(Zhang et al., 2000, Wang et al., 1994)

Df(3L)Aprt-9

(Wang et al., 1994)

Df(3L)Aprt-10

(Wang et al., 1994)

Df(3L)Aprt-12

(Wang et al., 1994)

Df(3L)Aprt-13

(Wang et al., 1994)

Df(3L)Aprt-14

(Zhang et al., 2000, Wang et al., 1994)

Df(3L)Aprt-16

(Wang et al., 1994)

Df(3L)Aprt-19

(Wang et al., 1994)

Df(3L)Aprt-24

(Machado and Andrew, 2000, Wang et al., 1994)

Df(3L)Aprt-26

(Wang et al., 1994)

Df(3L)Aprt-27

(Wang et al., 1994)

Df(3L)Aprt-29

(Wang et al., 1994)

Df(3L)Aprt-31

(Wang et al., 1994)

Df(3L)Aprt-32

(Spradling et al., 1999, Wang et al., 1994)

Df(3L)Aprt-36

(Wang et al., 1994)

Df(3L)Aprt-42

(Wang et al., 1994)

Df(3L)Aprt-46

(Wang et al., 1994)

Df(3L)Aprt-47

(Wang et al., 1994)

Df(3L)Aprt-53

(Wang et al., 1994)

Df(3L)Aprt-54

(Wang et al., 1994)

Df(3L)Aprt-61

(Wang et al., 1994)

Df(3L)Aprt-65

(Wang et al., 1994)

Df(3L)Aprt-72

(Wang et al., 1994)

Df(3L)Aprt-73

(Wang et al., 1994)

Df(3L)Aprt-74

(Wang et al., 1994)

Df(3L)Aprt-79

(Wang et al., 1994)

Df(3L)Aprt-87

(Wang et al., 1994)

Df(3L)Aprt-88

(Wang et al., 1994)

Df(3L)Aprt-91

(Wang et al., 1994)

Df(3L)Aprt-92

(Wang et al., 1994)

Df(3L)Aprt-93

(Wang et al., 1994)

Df(3L)Aprt-95

(Wang et al., 1994)

Df(3L)Aprt-98

(Wang et al., 1994)

Df(3L)Aprt-99

(Wang et al., 1994)

Df(3L)Aprt-100

(Wang et al., 1994)

Df(3L)Aprt-102

(Wang et al., 1994)

Df(3L)Aprt-105

(Wang et al., 1994)

Df(3L)Aprt-106

(Wang et al., 1994)

Df(3L)Aprt-107

(Wang et al., 1994)

Df(3L)Aprt-108

(Wang et al., 1994)

Df(3L)Aprt-109

(Wang et al., 1994)

Df(3L)Aprt-110

(Wang et al., 1994)

Df(3L)Aprt-112

(Wang et al., 1994)

Df(3L)Aprt-113

(Wang et al., 1994)

Df(3L)Aprt-114

(Wang et al., 1994)

Df(3L)Aprt-117

(Wang et al., 1994)

Df(3L)Aprt-122

(Wang et al., 1994)

Df(3L)Aprt-124

(Wang et al., 1994)

Df(3L)Aprt-130

(Wang et al., 1994)

Df(3L)Aprt-131

(Wang et al., 1994)

Df(3L)Aprt-133

(Wang et al., 1994)

Df(3L)Aprt-134

(Wang et al., 1994)

Df(3L)Aprt-137

(Wang et al., 1994)

Df(3L)Aprt-138

(Wang et al., 1994)

Df(3L)Aprt-140

(Wang et al., 1994)

Df(3L)Aprt-142

(Wang et al., 1994)

Df(3L)Aprt-143

(Machado and Andrew, 2000, Wang et al., 1994)

Df(3L)Aprt-144

(Wang et al., 1994)

Df(3L)Aprt-148

(Wang et al., 1994)

Df(3L)Aprt-151

(Wang et al., 1994)

Df(3L)Aprt-152

(Wang et al., 1994)

Df(3L)Aprt-153

(Wang et al., 1994)

Df(3L)Aprt-156

(Wang et al., 1994)

Df(3L)Aprt-159

(Wang et al., 1994)

Df(3L)Aprt-161

(Wang et al., 1994)

Df(3L)Aprt-162

(Wang et al., 1994)

Df(3L)Aprt-163

(Wang et al., 1994)

Df(3L)Aprt-164

(Wang et al., 1994)

Df(3L)Aprt-165

(Wang et al., 1994)

Df(3L)Aprt-166

(Wang et al., 1994)

Df(3L)Aprt-167

(Wang et al., 1994)

Df(3L)Aprt-169

(Wang et al., 1994)

Df(3L)Aprt-170

(Wang et al., 1994)

Df(3L)Aprt-172

(Wang et al., 1994)

Df(3L)Aprt-173

(Wang et al., 1994)

Df(3L)Aprt-175

(Wang et al., 1994)

Df(3L)Aprt-176

(Wang et al., 1994)

Df(3L)Aprt-177

(Wang et al., 1994)

Df(3L)Aprt-179

(Wang et al., 1994)

Df(3L)Aprt-181

(Wang et al., 1994)

Df(3L)Aprt-184

(Wang et al., 1994)

Df(3L)Aprt-186

(Wang et al., 1994)

Df(3L)Aprt-189

(Wang et al., 1994)

Df(3L)Aprt-191

(Wang et al., 1994)

Df(3L)Aprt-192

(Wang et al., 1994)

Df(3L)Aprt-193

(Wang et al., 1994)

Df(3L)Aprt-194

(Wang et al., 1994)

Df(3L)Aprt-199

(Zhang et al., 2000, Wang et al., 1994)

Df(3L)Aprt-201

(Wang et al., 1994)

Df(3L)BSC364

(Christensen et al., 2007.10.29)

Df(3L)BSC365

(Christensen et al., 2007.10.29)

Df(3L)BSC366

(Christensen et al., 2007.10.29)

Df(3L)R-G5

(Zhang et al., 2000, Spradling et al., 1999, Szeged Stock Center, 1998-, BDGP Project Members, 1994-1999)

Df(3L)R-G7

(Spradling et al., 1999, Szeged Stock Center, 1998-, Harding et al., 1995, BDGP Project Members, 1994-1999)

Ts(2Rt;3Rt)Aprt-185

(Wang et al., 1994)

Gene not disrupted in

Df(3L)Aprt-15

(Wang et al., 1994)

Df(3L)Aprt-18

(Machado and Andrew, 2000, Wang et al., 1994)

Df(3L)Aprt-21

(Wang et al., 1994)

Df(3L)Aprt-48

(Wang et al., 1994)

Df(3L)Aprt-56

(Wang et al., 1994)

Df(3L)Aprt-57

(Wang et al., 1994)

Df(3L)Aprt-66

(Wang et al., 1994)

Df(3L)Aprt-71

(Zhang et al., 2000, Wang et al., 1994)

Df(3L)Aprt-77

(Wang et al., 1994)

Df(3L)Aprt-84

(Wang et al., 1994)

Df(3L)Aprt-89

(Wang et al., 1994)

Df(3L)Aprt-90

(Wang et al., 1994)

Df(3L)Aprt-94

(Wang et al., 1994)

Df(3L)Aprt-96

(Zhang et al., 2000, Wang et al., 1994)

Df(3L)Aprt-97

(Wang et al., 1994)

Df(3L)Aprt-101

(Wang et al., 1994)

Df(3L)Aprt-103

(Wang et al., 1994)

Df(3L)Aprt-104

(Wang et al., 1994)

Df(3L)Aprt-111

(Wang et al., 1994)

Df(3L)Aprt-115

(Wang et al., 1994)

Df(3L)Aprt-116

(Wang et al., 1994)

Df(3L)Aprt-118

(Wang et al., 1994)

Df(3L)Aprt-119

(Wang et al., 1994)

Df(3L)Aprt-120

(Wang et al., 1994)

Df(3L)Aprt-121

(Wang et al., 1994)

Df(3L)Aprt-123

(Machado and Andrew, 2000, Zhang et al., 2000, Wang et al., 1994)

Df(3L)Aprt-125

(Wang et al., 1994)

Df(3L)Aprt-126

(Machado and Andrew, 2000, Wang et al., 1994)

Df(3L)Aprt-127

(Wang et al., 1994)

Df(3L)Aprt-128

(Wang et al., 1994)

Df(3L)Aprt-129

(Wang et al., 1994)

Df(3L)Aprt-132

(Wang et al., 1994)

Df(3L)Aprt-135

(Wang et al., 1994)

Df(3L)Aprt-136

(Wang et al., 1994)

Df(3L)Aprt-139

(Wang et al., 1994)

Df(3L)Aprt-141

(Wang et al., 1994)

Df(3L)Aprt-145

(Wang et al., 1994)

Df(3L)Aprt-146

(Wang et al., 1994)

Df(3L)Aprt-147

(Wang et al., 1994)

Df(3L)Aprt-149

(Wang et al., 1994)

Df(3L)Aprt-150

(Wang et al., 1994)

Df(3L)Aprt-154

(Wang et al., 1994)

Df(3L)Aprt-157

(Wang et al., 1994)

Df(3L)Aprt-158

(Wang et al., 1994)

Df(3L)Aprt-160

(Wang et al., 1994)

Df(3L)Aprt-168

(Wang et al., 1994)

Df(3L)Aprt-171

(Wang et al., 1994)

Df(3L)Aprt-174

(Wang et al., 1994)

Df(3L)Aprt-178

(Wang et al., 1994)

Df(3L)Aprt-179

(Wang et al., 1994)

Df(3L)Aprt-180

(Wang et al., 1994)

Df(3L)Aprt-182

(Wang et al., 1994)

Df(3L)Aprt-183

(Wang et al., 1994)

Df(3L)Aprt-187

(Wang et al., 1994)

Df(3L)Aprt-188

(Wang et al., 1994)

Df(3L)Aprt-190

(Wang et al., 1994)

Df(3L)Aprt-195

(Wang et al., 1994)

Df(3L)Aprt-196

(Wang et al., 1994)

Df(3L)Aprt-198

(Zhang et al., 2000, Wang et al., 1994)

Df(3L)HR370

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(3L)M21

(BDGP Project Members, 1994-1999)

Gene duplicated in

Ts(YLt;3Lt)B21

(Hakeda et al., 2000)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Scer\GAL4^elav.PLu

sls^GD9680

lethal, with Scer\GAL4^Mef2.PR

sls^GD9680

lethal - all die before end of larval stage

lethal - all die before end of larval stage, with Scer\GAL4^2-286

sls^GD9680

lethal - all die before end of larval stage, with Scer\GAL4^phtm.PU

sls^GD9680

lethal - all die before end of larval stage | recessive

lethal - all die during embryonic stage, with Scer\GAL4^Mef2.PR

lethal - all die during embryonic stage, with Scer\GAL4^Mhc.PK

sls^JF01099

lethal - all die during embryonic stage | recessive

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

sls^GD9680

partially lethal - majority die, with Scer\GAL4^pnr-MD237

sls^GD9680

viable

viable, with Scer\GAL4^tey-5053A

viable, with Scer\GAL4^tin.CΔ4

sls^GD9680

Other Phenotypes

Allele

abnormal locomotor behavior | embryonic stage | recessive

abnormal mitotic cell cycle

abnormal mitotic cell cycle (with sls^110ry-)

sls^e4

abnormal mitotic cell cycle (with sls^e4)

abnormal mitotic cell cycle (with sls^g65)

sls^e4

abnormal mitotic cell cycle (with sls^j1D7)

sls^e4

abnormal neuroanatomy | larval stage, with Scer\GAL4^tey-5053A

sls^JF01099

abnormal neurophysiology | larval stage, with Scer\GAL4^tey-5053A

sls^JF01099

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

sls^GD9680

abnormal size | larval stage, with Scer\GAL4^tey-5053A

sls^JF01099

decreased rate of larval locomotory behavior, with Scer\GAL4^tey-5053A

sls^JF01099

flightless | dominant

sls^Ket-14

paralytic | larval stage | recessive

sls^Ket-132

some die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

sls^GD9680

some die during embryonic stage | recessive

some die during larval stage

some die during larval stage | recessive

some die during pupal stage, with Scer\GAL4^pnr-MD237

sls^GD9680

visible, with Scer\GAL4^pnr-MD237

sls^GD9680

visible | pupal stage (with sls^g65)

sls^j1D7

visible | pupal stage (with sls^j1D7)

sls^g65

Phenotype manifest in

Allele

A1-7 ventral longitudinal muscle 1 | larval stage, with Scer\GAL4^tey-5053A

sls^JF01099

A band | larval stage, with Scer\GAL4^tey-5053A

sls^JF01099

dorsal longitudinal indirect flight muscle cell, with Scer\GAL4^Hk-UH3

sls^GD9680

embryonic/larval hypodermal muscle cell (with sls^e4)

sls^g05

embryonic/larval hypodermal muscle cell (with sls^g05)

sls^e4

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^tey-5053A

sls^JF01099

embryonic labral segment

sls^C138

embryonic midgut constriction

embryonic myoblast

I band | larval stage, with Scer\GAL4^tey-5053A

sls^JF01099

indirect flight muscle & myofibril

sls^Ket-14

indirect flight muscle & striated muscle thick filament

sls^Ket-14

indirect flight muscle & Z disc

larval muscle system

larval muscle system | third instar larval stage (with sls^e4)

sls^g05

larval muscle system | third instar larval stage (with sls^g05)

sls^e4

muscle tendon junction | embryonic stage

median tooth | ectopic

sls^C138

mesonotum, with Scer\GAL4^pnr-MD237

sls^GD9680

mitosis & nuclear chromosome

mitosis & nuclear chromosome (with sls^110ry-)

sls^e4

mitosis & nuclear chromosome (with sls^e4)

mitosis & nuclear chromosome (with sls^g65)

sls^e4

mitosis & nuclear chromosome (with sls^j1D7)

sls^e4

mitotic cell cycle

mitotic cell cycle (with sls^110ry-)

sls^e4

mitotic cell cycle (with sls^e4)

mitotic cell cycle (with sls^g65)

sls^e4

mitotic cell cycle (with sls^j1D7)

sls^e4

motor neuron | larval stage, with Scer\GAL4^tey-5053A

sls^JF01099

muscle fiber & nucleus & embryo

sls^Ket-14

myofibril

NMJ bouton | decreased number | larval stage, with Scer\GAL4^tey-5053A

sls^JF01099

nucleus

sls^e4

nucleus | decreased number | larval stage, with Scer\GAL4^tey-5053A

sls^JF01099

pupal cuticle (with sls^e4)

pupal cuticle (with sls^g05)

sls^e4

pupal cuticle (with sls^S002001)

sls^e4

sarcomere

sarcomere, with Scer\GAL4^Mef2.PR

sls^GD9680

sarcomere | adult stage, with Scer\GAL4^Hk-UH3

sls^GD9680

sarcomere | embryonic stage

sls^Ket-14

sarcomere | larval stage, with Scer\GAL4^tey-5053A

sls^JF01099

striated muscle myosin thick filament | embryonic stage

sls^Ket-14

striated muscle thin filament | embryonic stage

sls^Ket-14

trichogen cell, with Scer\GAL4^pnr-MD237

sls^GD9680

type Ib motor neuron | larval stage, with Scer\GAL4^tey-5053A

sls^JF01099

type Is motor neuron | larval stage, with Scer\GAL4^tey-5053A

sls^JF01099

visceral muscle fiber | embryonic stage

Z disc, with Scer\GAL4^Mef2.PR

sls^GD9680

Z disc | embryonic stage

sls^Ket-14

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (117)

Hsap\MYLK

3 of 14

Yes

Hsap\OBSCN

3 of 14

Yes

Hsap\OBSL1

3 of 14

Yes

Hsap\TTN

3 of 14

Yes

Hsap\CD22

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\PTK7

2 of 14

Hsap\SPEG

2 of 14

Hsap\ALPK3

1 of 14

Yes

Hsap\BMPER

1 of 14

Hsap\BOC

1 of 14

Hsap\BTN2A2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CEACAM16

1 of 14

Hsap\CFP

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CRIM1

1 of 14

Hsap\CRTAM

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\FCRL5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\FSTL5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\MFAP3L

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF500

1 of 14

Hsap\ZNF544

1 of 14

Hsap\ZNF705F

1 of 14

Yes

Hsap\ZNF853

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (67)

Rnor\Mylk

3 of 14

Yes

Rnor\Hmcn1

2 of 14

Rnor\Mypn

2 of 14

Yes

Rnor\Obscn

2 of 14

Rnor\Obsl1

2 of 14

Rnor\Palldl1

2 of 14

Yes

Rnor\Palld

2 of 14

Yes

Rnor\Speg

2 of 14

Rnor\Bmper

1 of 14

Rnor\Btnl9

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Ceacam3

1 of 14

Yes

Rnor\Ceacam16

1 of 14

Rnor\Ceacam18

1 of 14

Yes

Rnor\Cfp

1 of 14

Yes

Rnor\Cntn4

1 of 14

Rnor\Crim1

1 of 14

Rnor\Crtam

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Igsf23

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Med15

1 of 14

Rnor\Mfap3l

1 of 14

Yes

Rnor\Mfap3

1 of 14

Yes

Rnor\Myom1

1 of 14

Rnor\Myom3

1 of 14

Rnor\Myot

1 of 14

Yes

Rnor\Ndp

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Vwa7

1 of 14

Rnor\Vwf

1 of 14

Mus musculus (laboratory mouse) (74)

Mmus\Obscn

4 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Ceacam3

1 of 14

Yes

Mmus\Ceacam5

1 of 14

Yes

Mmus\Ceacam16

1 of 14

Mmus\Ceacam18

1 of 14

Yes

Mmus\Cfp

1 of 14

Yes

Mmus\Cntn4

1 of 14

Mmus\Coch

1 of 14

Yes

Mmus\Crim1

1 of 14

Mmus\Crtam

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Igfn1

1 of 14

Mmus\Igsf5

1 of 14

Yes

Mmus\Igsf23

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Med15

1 of 14

Mmus\Mfap3l

1 of 14

Yes

Mmus\Mfap3

1 of 14

Yes

Mmus\Muc5ac

1 of 14

Mmus\Muc5b

1 of 14

Mmus\Myot

1 of 14

Yes

Mmus\Ndp

1 of 14

Yes

Mmus\Nefm

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Psg16

1 of 14

Yes

Mmus\Psg20

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Skint8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (61)

Xtro\mypn

2 of 13

Yes

Xtro\prtg

2 of 13

Yes

Xtro\speg

2 of 13

Yes

Xtro\XB5889096

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\mfap3

1 of 13

Yes

Xtro\MGC107841

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ndrg1

1 of 13

Xtro\nectin1l1

1 of 13

Yes

Xtro\nol6

1 of 13

Xtro\npffr1.1

1 of 13

Xtro\obscn

1 of 13

Yes

Xtro\optn

1 of 13

Xtro\palld

1 of 13

Yes

Xtro\pcasp3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\sh3pxd2b

1 of 13

Yes

Xtro\sipa1l1

1 of 13

Yes

Xtro\sp4

1 of 13

Xtro\spice1

1 of 13

Yes

Xtro\velo1

1 of 13

Yes

Xtro\vps28

1 of 13

Xtro\zswim9

1 of 13

Danio rerio (Zebrafish) (150)

Drer\spegb

3 of 14

Yes

Drer\hmcn2

2 of 14

Drer\mybpc2a

2 of 14

Drer\palld

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\crim1

1 of 14

Drer\crtam

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\igsf9bb

1 of 14

Drer\igsf11

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100004104

1 of 14

Yes

Drer\LOC100006469

1 of 14

Yes

Drer\LOC100006764

1 of 14

Yes

Drer\LOC100006875

1 of 14

Yes

Drer\LOC100007935

1 of 14

Yes

Drer\LOC100151078

1 of 14

Yes

Drer\LOC100329818

1 of 14

Yes

Drer\LOC100331974

1 of 14

Yes

Drer\LOC100333939

1 of 14

Yes

Drer\LOC100334619

1 of 14

Yes

Drer\LOC100334996

1 of 14

Yes

Drer\LOC100535756

1 of 14

Yes

Drer\LOC100536726

1 of 14

Yes

Drer\LOC101882696

1 of 14

Yes

Drer\LOC101883325

1 of 14

Drer\LOC101883331

1 of 14

Yes

Drer\LOC101883412

1 of 14

Yes

Drer\LOC101883645

1 of 14

Yes

Drer\LOC101884052

1 of 14

Yes

Drer\LOC101884775

1 of 14

Yes

Drer\LOC101886743

1 of 14

Yes

Drer\LOC101886796

1 of 14

Yes

Drer\LOC103908669

1 of 14

Yes

Drer\LOC103909724

1 of 14

Yes

Drer\LOC108179342

1 of 14

Yes

Drer\LOC110437733

1 of 14

Yes

Drer\lrig1

1 of 14

Drer\med15

1 of 14

Drer\mfap3l

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\mypn

1 of 14

Yes

Drer\ndp

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:ch73-27e22.1

1 of 14

Yes

Drer\si:ch73-27e22.2

1 of 14

Yes

Drer\si:ch73-27e22.4

1 of 14

Yes

Drer\si:ch73-27e22.6

1 of 14

Yes

Drer\si:ch73-27e22.7

1 of 14

Yes

Drer\si:ch73-44m9.1

1 of 14

Drer\si:ch73-170d6.3

1 of 14

Yes

Drer\si:ch73-213k20.5

1 of 14

Yes

Drer\si:ch73-237c6.1

1 of 14

Yes

Drer\si:ch73-256j6.4

1 of 14

Yes

Drer\si:ch73-256j6.6

1 of 14

Yes

Drer\si:ch73-304f21.1

1 of 14

Yes

Drer\si:ch73-380l3.2

1 of 14

Yes

Drer\si:ch73-380l3.3

1 of 14

Yes

Drer\si:ch73-380l3.4

1 of 14

Yes

Drer\si:ch211-39f2.3

1 of 14

Drer\si:ch211-209l18.2

1 of 14

Yes

Drer\si:ch211-209l18.4

1 of 14

Yes

Drer\si:ch211-213a13.1

1 of 14

Yes

Drer\si:ch211-241b2.5

1 of 14

Yes

Drer\si:ch211-264f5.6

1 of 14

Drer\si:ch211-274k16.2

1 of 14

Yes

Drer\si:ch211-274k16.9

1 of 14

Yes

Drer\si:dkey-11f4.14

1 of 14

Yes

Drer\si:dkey-19a16.2

1 of 14

Yes

Drer\si:dkey-19a16.4

1 of 14

Yes

Drer\si:dkey-19a16.5

1 of 14

Yes

Drer\si:dkey-19a16.7

1 of 14

Yes

Drer\si:dkey-19a16.12

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:dkey-182g1.2

1 of 14

Yes

Drer\si:dkey-182g1.3

1 of 14

Yes

Drer\si:dkey-182g1.4

1 of 14

Yes

Drer\si:dkey-182g1.6

1 of 14

Yes

Drer\si:dkey-182g1.10

1 of 14

Yes

Drer\si:dkey-222f2.7

1 of 14

Yes

Drer\si:dkey-253d23.3

1 of 14

Yes

Drer\si:rp71-1i20.2

1 of 14

Yes

Drer\si:rp71-36a1.1

1 of 14

Yes

Drer\si:rp71-36a1.2

1 of 14

Yes

Drer\si:rp71-36a1.3

1 of 14

Yes

Drer\si:rp71-36a1.5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\vwa10.1

1 of 14

Yes

Drer\vwa10.2

1 of 14

Yes

Drer\vwf

1 of 14

Drer\zgc:113298

1 of 14

Yes

Drer\zgc:171470

1 of 14

Drer\zgc:171490

1 of 14

Yes

Drer\zgc:171497

1 of 14

Yes

Drer\zgc:171500

1 of 14

Yes

Drer\zgc:171686

1 of 14

Yes

Drer\zgc:172106

1 of 14

Drer\zgc:172133

1 of 14

Yes

Drer\zmp:0000000650

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (48)

Cele\ketn-1

8 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Cele\bli-3

1 of 14

Cele\C16E9.1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\F19C6.3

1 of 14

Cele\F32D8.3

1 of 14

Cele\F35E12.6

1 of 14

Yes

Cele\H13N06.2

1 of 14

Yes

Cele\him-4

1 of 14

Cele\hpx-2

1 of 14

Cele\irg-5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\oig-4

1 of 14

Cele\pals-39

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\unc-52

1 of 14

Cele\Y8A9A.2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\zig-8

1 of 14

Cele\zig-12

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (98)

Agam\AgaP_AGAP007563

10 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP010633

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\AT5G58280

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CSS1

1 of 13

Yes

Scer\HPF1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:sls. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (85)

4 of 13

Obsc

4 of 13

zormin

3 of 13

MnM

2 of 13

otk2

2 of 13

otk

2 of 13

Strn-Mlck

2 of 13

Ama

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Cpn

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

dpy

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

fra

1 of 13

hbs

1 of 13

Hml

1 of 13

ImpL2

1 of 13

kirre

1 of 13

Lac

1 of 13

Lar

1 of 13

MED15

1 of 13

Muc14A

1 of 13

nkt

1 of 13

Nrg

1 of 13

Phs

1 of 13

plum

1 of 13

Ppn

1 of 13

Ptp99A

1 of 13

Pxd

1 of 13

Pxn

1 of 13

Pxt

1 of 13

Rcd2

1 of 13

robo3

1 of 13

rst

1 of 13

sdk

1 of 13

shot

1 of 13

sns

1 of 13

tei

1 of 13

trabl

1 of 13

trol

1 of 13

Zif

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

sls^ZCL2144

model of myopathy

CEA

(González-Morales et al., 2017)

DOES NOT model myopathy

CEA with cher^CPTI001403

(González-Morales et al., 2017)

Potential Models Based on Orthology ( 8 )

Human Ortholog

Disease

Evidence

References

MYLK; myosin light chain kinase

model of thoracic aortic aneurysm

IEA

(FlyBase, 2019-)

OBSL1; obscurin like cytoskeletal adaptor 1

model of 3-M syndrome

IEA

(FlyBase, 2019-)

TTN; titin

model of autosomal recessive limb-girdle muscular dystrophy type 2J

IEA

(FlyBase, 2019-)

model of congenital myopathy 5

IEA

(FlyBase, 2019-)

model of tibial muscular dystrophy

IEA

(FlyBase, 2019-)

model of dilated cardiomyopathy 1G

IEA

(FlyBase, 2019-)

model of hypertrophic cardiomyopathy 9

IEA

(FlyBase, 2019-)

model of myofibrillar myopathy 9

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

sls¹

exacerbates myopathy

modeled by cher^JF02077

(González-Morales et al., 2017)

sls^KG00981

ameliorates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

sls^j1D7

exacerbates myopathy

modeled by cher^JF02077

(González-Morales et al., 2017)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MYLK; myosin light chain kinase

3 of 14

600922

thoracic aortic aneurysm

OBSCN; obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

3 of 14

608616

RHABDOMYOLYSIS, SUSCEPTIBILITY TO, 1; RHABDO1

OBSL1; obscurin like cytoskeletal adaptor 1

3 of 14

610991

THREE M SYNDROME 2; 3M2

3-M syndrome

TTN; titin

3 of 14

188840

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

sls - Lasp

anti tag coimmunoprecipitation, peptide massfingerprinting

(Fernandes and Schöck, 2014)

sls - Msp300

anti bait coimmunoprecipitation, western blot

(Elhanany-Tamir et al., 2012)

sls - Sos

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

sls - cher

anti tag coimmunoprecipitation, anti tag western blot, western blot, pull down

(González-Morales et al., 2017)

RNA-RNA

Physical Interaction

Assay

References

sls - mir-9a

quantitative reverse transcription pcr

(Yatsenko and Shcherbata, 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

cher

(González-Morales et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

cher

enhanceable

(González-Morales et al., 2017)

Dfd

enhanceable

(Harding et al., 1995)

E(z)

suppressible

(Bajusz et al., 2001)

Mlp84B

enhanceable

(Clark et al., 2007)

suppressible

(Kennison and Tamkun, 1988)

suppressible