Gene Group: LYASES

General Information

Name

LYASES

Species

D. melanogaster

Symbol

LYA

FlyBase ID

FBgg0000808

Date last reviewed

2019-11-08

Number of members

129

Description

Lyases are a class of enzymes that catalyze the cleavage of carbon-carbon, carbon-oxygen, carbon-nitrogen and other bonds by elimination reaction, leaving double bonds or rings or conversely adding groups to double bonds. (Adapted from FBrf0238856).

Notes on Group

Source Material

The LYASES Gene Group has been compiled using the following publication(s): Werner et al., 2024, François et al., 2023, Sopko et al., 2014, Cheng et al., 2013, Syrjänen et al., 2013, Vogel et al., 2013, Selby and Sancar, 2012, Vermehren-Schmaedick et al., 2011, Cooper et al., 2010, Ortutay et al., 2010, Vermehren-Schmaedick et al., 2010, Anamika et al., 2009, Biswas et al., 2009, Linser et al., 2009, Ueno and Kidokoro, 2008, Lind et al., 2006, Morton et al., 2005, Langlais et al., 2004, Morton, 2004, Manning et al., 2002, Cann et al., 2000, and Morrison et al., 2000 .

Key Gene Ontology (GO) terms

Molecular Function

lyase activity

Biological Process

Cellular Component

Enzymatic activity

Enzyme name (EC)

4.-.-.-

Related Gene Groups

Parent group(s)

ENZYMES

Component group(s)

CARBON-CARBON LYASES

CARBON-HALIDE LYASES

CARBON-NITROGEN LYASES

CARBON-OXYGEN LYASES

CARBON-SULFUR LYASES

FERROCHELATASES

PHOSPHORUS-OXYGEN LYASES

Members (129)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

5'-DEOXYRIBOSE-5-PHOSPHATE LYASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Irbp

Inverted repeat-binding protein

Ku70, YPF1, DmKu70, YPF1β, Ku

(FlyBase, 2017-)

PolQ

DNA polymerase theta

mus308, Pol θ

(FlyBase, 2017-)

ACONITASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Irp-1A

Iron regulatory protein 1A

IRP1A, c-aconitase, IRP-1, cytosolic aconitase, IRP

(François et al., 2023, FlyBase, 2017-, Lind et al., 2006)

Irp-1B

Iron regulatory protein 1B

cytosolic aconitase, IRP1B, IRP-1, c-aconitase, IRP

(François et al., 2023, FlyBase, 2017-, Lind et al., 2006)

mAcon1

Mitochondrial aconitase 1

Acon, Aconitase, mitochondrial aconitase, mAcon, m-aconitase

(François et al., 2023, FlyBase, 2017-, Cheng et al., 2013)

mAcon2

Mitochondrial aconitase 2

(François et al., 2023, FlyBase, 2017-, Cheng et al., 2013)

ADENYLATE CYCLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ac3

Adenylate cyclase 3

DAC3, DAC39E

(FlyBase, 2017-, Ueno and Kidokoro, 2008, Cann et al., 2000, Morrison et al., 2000)

Ac13E

Adenylyl cyclase 13E

DAC9, Adenylyl cyclase 35C

(FlyBase, 2017-, Ueno and Kidokoro, 2008, Cann et al., 2000, Morrison et al., 2000)

Ac76E

Adenylyl cyclase 76E

DAC76E

(FlyBase, 2017-, Ueno and Kidokoro, 2008, Cann et al., 2000, Morrison et al., 2000)

Ac78C

Adenylyl cyclase 78C

(FlyBase, 2017-, Ueno and Kidokoro, 2008, Morrison et al., 2000)

ACXA

Adenylyl cyclase X A

Ac62D

(FlyBase, 2017-, Ueno and Kidokoro, 2008, Cann et al., 2000, Morrison et al., 2000)

ACXB

Adenylyl cyclase X B

Ac34A

(FlyBase, 2017-, Ueno and Kidokoro, 2008, Cann et al., 2000, Morrison et al., 2000)

ACXC

Adenylyl cyclase X C

(FlyBase, 2017-, Ueno and Kidokoro, 2008, Cann et al., 2000, Morrison et al., 2000)

ACXD

Adenylyl cyclase X D

(FlyBase, 2017-, Ueno and Kidokoro, 2008, Cann et al., 2000, Morrison et al., 2000)

ACXE

Adenylyl cyclase X E

(FlyBase, 2017-, Ueno and Kidokoro, 2008, Cann et al., 2000, Morrison et al., 2000)

Adcy1

Adenylate cyclase 1

rut, rutabaga, AC, adenylyl cyclase, Rut-AC

(FlyBase, 2017-, Ueno and Kidokoro, 2008)

CG32301

(FlyBase, 2017-, Ueno and Kidokoro, 2008, Morrison et al., 2000)

CG32305

(FlyBase, 2017-, Ueno and Kidokoro, 2008, Morrison et al., 2000)

CG43373

(FlyBase, 2017-, Ueno and Kidokoro, 2008, Morrison et al., 2000)

ALDEHYDE DECARBONYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cyp4g1

Cytochrome P450 4g1

T1, EG:165H7.1, ASC-T1, P450, P-450-A

(FlyBase, 2017-)

ALDEHYDE-LYASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ald1

Aldolase 1

Ald, Aldolase

(FlyBase, 2017-)

Ald2

Aldolase 2

(FlyBase, 2017-)

CG10184

(FlyBase, 2017-)

Dera

Deoxyribose-phosphate aldolase

(FlyBase, 2017-)

Hacl

2-hydroxyacyl-CoA lyase

HACL1

(FlyBase, 2017-)

Sply

Sphingosine-1-phosphate lyase

l(2)05091

(FlyBase, 2017-)

AMIDINE-LYASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Adsl

Adenylosuccinate lyase

(FlyBase, 2017-)

Argl

Argininosuccinate lyase

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Peptidyl-α-hydroxyglycine-α-amidating lyase 1

tapered, ta

(FlyBase, 2017-)

Pal2

Peptidyl-α-hydroxyglycine-α-amidating lyase 2

Pal

(FlyBase, 2017-)

Tina-1

Troponin C-akin-1

(FlyBase, 2017-)

AMMONIA-LYASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Srr

Serine racemase

(FlyBase, 2017-)

CARBON-HALIDE LYASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

GstD1

Glutathione S transferase D1

GST, DmGSTD1, gstD, DmGST1, GST-1

(FlyBase, 2017-)

CARBONIC ANHYDRASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CAH1

Carbonic anhydrase 1

BG:DS00941.1, CAH

(FlyBase, 2017-, Syrjänen et al., 2013, Ortutay et al., 2010, Linser et al., 2009)

CAH2

Carbonic anhydrase 2

(FlyBase, 2017-, Syrjänen et al., 2013, Ortutay et al., 2010, Linser et al., 2009)

CAH3

Carbonic anhydrase 3

(FlyBase, 2017-, Ortutay et al., 2010, Linser et al., 2009)

CAH4

Carbonic anhydrase 4

(FlyBase, 2017-, Ortutay et al., 2010, Linser et al., 2009)

CAH5

Carbonic anhydrase 5

(FlyBase, 2017-, Ortutay et al., 2010, Linser et al., 2009)

CAH6

Carbonic anhydrase 6

(FlyBase, 2017-, Ortutay et al., 2010, Linser et al., 2009)

CAH7

Carbonic anhydrase 7

(FlyBase, 2017-, Ortutay et al., 2010, Linser et al., 2009)

CAH8

Carbonic anhydrase 8

(FlyBase, 2017-, Ortutay et al., 2010, Linser et al., 2009)

CAH9

Carbonic anhydrase 9

caix

(FlyBase, 2017-, Ortutay et al., 2010, Linser et al., 2009)

CAH13

Carbonic anhydrase 13

(FlyBase, 2017-, Ortutay et al., 2010, Linser et al., 2009)

CAH14

Carbonic anhydrase 14

(FlyBase, 2017-, Ortutay et al., 2010, Linser et al., 2009)

CAH15

Carbonic anhydrase 15

(FlyBase, 2017-, Ortutay et al., 2010, Linser et al., 2009)

CAH16

Carbonic anhydrase 16

(FlyBase, 2017-, Ortutay et al., 2010, Linser et al., 2009)

CAHβ

Carbonic anhydrase β

DmBCA, β-carbonic anhydrase

(FlyBase, 2017-, Syrjänen et al., 2013, Ortutay et al., 2010)

CARPA

Carbonic anhydrase-related protein A

(FlyBase, 2017-, Ortutay et al., 2010, Linser et al., 2009)

CARPB

Carbonic anhydrase-related protein B

(FlyBase, 2017-, Ortutay et al., 2010, Linser et al., 2009)

CARBON-OXYGEN LYASES, ACTING ON PHOSPHATES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG8745

(FlyBase, 2017-)

purple

38B.9, PTPS

(FlyBase, 2017-)

CARBON-SULFUR LYASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cchl

Cytochrome c heme lyase

(FlyBase, 2017-)

Cth

Cystathionine gamma-lyase

Eip55E, Eip40, CSE, cystathionine γ-lyase

(FlyBase, 2017-)

Glo1

Glyoxalase 1

(FlyBase, 2017-)

Kyat

Kynurenine aminotransferase

(FlyBase, 2017-)

CARBOXY-LYASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Adc

Acidic amino acid decarboxylase

b, black, Gad2, DGad2, anon-34Db

(FlyBase, 2017-)

amd

α methyl dopa-resistant

l(2)amd, dopa decarboxylase, alpha methyl dopa

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Dopa decarboxylase

AADC

(FlyBase, 2017-)

Gad1

Glutamic acid decarboxylase 1

Gad, glutamic acid decarboxylase, l(3)64An, DGad1, glutamatic acid decarboxylase

(FlyBase, 2017-)

gamma-glutamyl carboxylase

γ-glutamyl carboxylase, DγC

(FlyBase, 2017-)

Hdc

Histidine decarboxylase

(FlyBase, 2017-)

Mvd

Mevalonate diphosphate decarboxylase

(FlyBase, 2017-)

Odc1

Ornithine decarboxylase 1

ornithine decarboxylase

(FlyBase, 2017-)

Odc2

Ornithine decarboxylase 2

(FlyBase, 2017-)

Paics

PAICS bifunctional enzyme

ade5, AIRc-SAICARs, AIR-carboxylase-SAICAR synthetase

(FlyBase, 2017-)

Pepck1

Phosphoenolpyruvate carboxykinase 1

Pepck, phosphoenolpyruvate carboxykinase

(FlyBase, 2017-)

Pepck2

Phosphoenolpyruvate carboxykinase 2

PEPCK

(FlyBase, 2017-)

Pisd

Phosphatidylserine decarboxylase

Psd

(FlyBase, 2017-)

Ppcdc

Phosphopantothenoylcysteine decarboxylase

dPPCDC, (R)-4'-phospho-N-pantothenoylcysteine decarboxylase

(FlyBase, 2017-)

r-l

rudimentary-like

UMP synthase

(FlyBase, 2017-)

SamDC

S-adenosylmethionine decarboxylase

l(2)31Dc, l(2)31Dd, l(2)31De

(FlyBase, 2017-)

Tdc1

Tyrosine decarboxylase 1

TDC, tyrosine decarboxylase

(FlyBase, 2017-)

Tdc2

Tyrosine decarboxylase 2

TDC, tyrosine decarboxylase, dTdc2

(FlyBase, 2017-)

Urod

Uroporphyrinogen decarboxylase

Updo

(FlyBase, 2017-)

Uxs

UDP-xylose synthase

(FlyBase, 2017-)

CYCLIC PYRANOPTERIN MONOPHOSPHATE SYNTHASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Mocs1

Molybdenum cofactor synthesis 1

lxd

(FlyBase, 2017-)

DNA-(APURINIC OR APYRIMIDINIC SITE) LYASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

AlkB

(FlyBase, 2017-)

Nthl1

Nth-like DNA glycosylase 1

(FlyBase, 2017-)

Ogg1

8-oxoguanine DNA glycosylase

(FlyBase, 2017-)

RpS3

Ribosomal protein S3

M(3)95A, M(3)w, S3, M(3R)w, Minute

(FlyBase, 2017-)

DNA PHOTOLYASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

phr

photorepair

(FlyBase, 2017-, Selby and Sancar, 2012)

phr6-4

(6-4)-photolyase

38D.25, 6-4 photolyase

(Selby and Sancar, 2012)

FERROCHELATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

FeCH

Ferrochelatase

(FlyBase, 2017-)

FUMARATE HYDRATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Fum1

Fumarase 1

l(1)G0255, Fum, l(1)G0290, lethal (1) G0255, Fumarate hydratase

(François et al., 2023, FlyBase, 2017-)

Fum2

Fumarase 2

(François et al., 2023, FlyBase, 2017-)

Fum3

Fumarase 3

(François et al., 2023, FlyBase, 2017-)

Fum4

Fumarase 4

(François et al., 2023, FlyBase, 2017-)

GTP 3',8'-CYCLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Mocs1

Molybdenum cofactor synthesis 1

lxd

(FlyBase, 2017-)

OXO-ACID-LYASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Hmgcl

3-Hydroxymethyl-3-methylglutaryl-CoA lyase

(FlyBase, 2017-)

RECEPTOR GUANYLATE CYCLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3216

(Werner et al., 2024, Sopko et al., 2014, Vogel et al., 2013, Anamika et al., 2009, Biswas et al., 2009, Manning et al., 2002)

CG10738

(Werner et al., 2024, Sopko et al., 2014, Vogel et al., 2013, Anamika et al., 2009, Biswas et al., 2009, Manning et al., 2002)

CG31183

(Werner et al., 2024, Sopko et al., 2014, Vogel et al., 2013, Anamika et al., 2009, Biswas et al., 2009, Manning et al., 2002)

CG33958

(Biswas et al., 2009)

CG42637

(Vogel et al., 2013, Cooper et al., 2010)

Gucy2d

Guanylate cyclase 2d

(Werner et al., 2024, Sopko et al., 2014, Vogel et al., 2013, Biswas et al., 2009, Manning et al., 2002)

Gyc32E

Guanylyl cyclase at 32E

GC, Guanyl cyclase at 32E

(Werner et al., 2024, Vogel et al., 2013, Anamika et al., 2009, Biswas et al., 2009, Manning et al., 2002)

Gyc76C

Guanylyl cyclase at 76C

l(3)76BDl, DrGC-1, drgc, gimli

(Werner et al., 2024, Vogel et al., 2013, Cooper et al., 2010, Biswas et al., 2009, Manning et al., 2002)

RIBONUCLEASE T2S

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

RNaseX25

Ribonuclease X25

DmRNase-X25, RNase X25

(FlyBase, 2017-)

SOLUBLE GUANYLATE CYCLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Gycα99B

Guanylyl cyclase α-subunit at 99B

dgc1, dgcα1, Gcα1, Gycα-99B, dgca1

(Morton et al., 2005, Langlais et al., 2004, Morton, 2004)

Gycβ100B

Guanylyl cyclase β-subunit at 100B

Gycβ-100B, dgcb1

(Morton et al., 2005, Langlais et al., 2004, Morton, 2004)

SOLUBLE GUANYLATE CYCLASES ATYPICAL

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Gyc88E

Guanylyl cyclase at 88E

Gyc-88E

(Vermehren-Schmaedick et al., 2011, Vermehren-Schmaedick et al., 2010, Morton et al., 2005, Langlais et al., 2004, Morton, 2004)

Gyc89Da

Guanylyl cyclase at 89Da

Gyc-89Da

(Werner et al., 2024, Vermehren-Schmaedick et al., 2011, Vermehren-Schmaedick et al., 2010, Morton et al., 2005, Langlais et al., 2004, Morton, 2004)

Gyc89Db

Guanylyl cyclase at 89Db

Gyc-89Db

(Werner et al., 2024, Vermehren-Schmaedick et al., 2011, Vermehren-Schmaedick et al., 2010, Morton et al., 2005, Langlais et al., 2004, Morton, 2004)

UNCLASSIFIED HYDRO-LYASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cbs

Cystathionine β-synthase

dCBS

(FlyBase, 2017-)

CG2794

(FlyBase, 2017-)

CG6984