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FB2026_01
,
released March 12, 2026
fettucine, fet, E(Dl)D49
transcription factor - HMG box protein - acts as a repressor of tailless and huckebein in both the anterior and posterior domains of the early Drosophila embryo - a general sensor of RTK signaling - Capicua-dependent gene silencing is alleviated by MAPK/Erk phosphorylation, which causes Cic translocation from the nucleus to the cytoplasm.
Please see the JBrowse view of Dmel\cic for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.47
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
5.175 (sequence analysis)
None of the polypeptides share 100% sequence identity.
1403 (aa)
Interacts with gro.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cic using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
cic transcripts are present at high levels in early blastoderm embryos, consistent with maternal expression and decay rapidly thereafter. They are barely detectable by gastrulation.
At stage 10A, cic is excluded from nuclei of the dorsal anterior follicle cells. At stage 10B, cic is excluded from the nuclei within a broad patch of dorsal cells. By stage 12 cic is excluded from the nuclei in and around two dorsolateral stripes of the follicle cells. At the same time, nuclear cic reappears in the triangular patch on the dorsal side, closer to the anterior tip of the egg chamber.
cic protein is detected in the eye imaginal disc. There is a stripe of increased expression just anterior to the furrow and less within the furrow.
cic protein is present in blastoderm embryos in nuclei in the trunk region. It is absent from both poles.
JBrowse - Visual display of RNA-Seq signals
View Dmel\cic in JBrowse3-68
3-71.7
3-67.2--68.6
3-72.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
New stable cell line derived from S2-unspecified : An S2 cell line expressing cic tagged with Tag:SBP was created. S2 cells were obtained from the laboratory of S. Artavanis-Tsakonas.
New stable cell line derived from S2-unspecified : expressing Tag:SBP tagged cic.
New annotation (CG43122) in release 5.32 of the genome annotation.
cic represses appendage-producing follicle cell fate during development.
Mutant embryos form head and tail structures but lack most of the segmented trunk.
Identification: fettucine was originally isolated by D. Morisato as a dominant suppressor of spzDom.
Source for merge of: cic CG5067
Source for merge of: E(Dl)D49 cic
Source for merge of: cic CG5060
Annotations CG5067 and CG5060 merged as CG43122 in release 5.32 of the genome annotation.
"hab" is allelic to "cic" and "bwk". This locus is genetically and molecularly complex, encoding distinct genetic functions and producing multiple isoforms.
Molecular analysis indicates that the "fet" and "cic" mutations are allelic (mutant lesions responsible for "fet" mutations are located in the open reading frame of the "cic" gene, and a "cic" rescue construct rescues the maternal and zygotic "fet" phenotypes). cic1/cicfet-U6 females produce embryos with a tor gain-of-function phenotype, indicating that both alleles affect the same germline function. However, cic1 complements the follicle cell defect of "fet" mutants, as eggs laid by transheterozygous females show apparently normal dorsoventral polarity of the eggshell and embryo. The relationship between "cic" (and therefore "fet") and "bwk" is unclear. "bwk" alleles complement the "fet" eggshell and wing defects, while the embryos laid by "fet"/"bwk" transheterozygotes are bicaudal (maternal effect "bwk" mutations result in bicaudal embryos).
The P{PZ} insertion in "bwk08482" maps approximately 300bp away from the hobo insertion in "cic1". However, "cic1" and "bwk08482" complement each other, produce different phenotypes and while the P{cic+tJa} construct rescues "cic1", it does not rescue "bwk08482", indicating that "bwk" and cic represent separate gene functions.
Source for identity of: cic fet
The gene is named "capicua", Catalan for "head-and-tail", after the phenotype of embryos produced by homozygous females (they form head and tail structures but lack most of the segmented trunk).
"capicua" is Catalonian for "head-and-tail".
