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FB2026_01
,
released March 12, 2026
fmi, flamingo, CT20776
Cadherin-related 7TM protein involved in tissue polarity - epithelial microRNA-9a regulates dendrite growth through Fmi-Gq signaling in Drosophila sensory neurons
Please see the JBrowse view of Dmel\stan for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
The transcript designation "stan-RA" and protein designation "stan-PA" have been used for different isoforms in different releases.
Stop-codon suppression (UGA) postulated; FBrf0216884
Gene model reviewed during 5.44
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.49
Alternative translation stop created by use of multiphasic reading frames within coding region.
>12 (northern blot)
3579 (aa)
Interacts with ATP6AP2 (via N-terminus).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\stan using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
stan transcripts are most abundant in 6-9hr embryos and are more abundant in pupae than larvae. They are found to be at relatively even levels all over the pupal wing by in situ hybridization.
stan is enriched to high levels at the interface between R8 and the two to three contacting interommatidial cells, whereas variable amounts accumulates at the interface between R3/R4 photoreceptor precurors and the five to seven contacting interommatidial cells.
stan is found in the region of the developing sex comb in the distal transverse row bristle and sex combs and to a lesser extent on the adjacent transverse row bristles.
stan is strongly expressed in all sensory cell bodies and in sensory and motor axons from early stage 13 through to late embryogenesis. It is also expressed in all primary tracheal branches including the dorsal trunk, dorsal branch, transverse connective, ganglionic branch, lateral trunk, and spiracular branch. Expression is restricted to the lateral and apical (luminal) surfaces of the tracheal cells except for the posterior lateral trunk where it is found over the whole tracheal surface.
stan protein is detected in the CNS and PNS of embryos at 18h AEL. In the CNS, it is detected in the motor axons that innervate the body wall muscles (hypodermal) and at the presynaptic sites of the neuromuscular junction. It is also detected in the nerve roots that exit the ventral nerve cord. Western blot analyses indicates that it is expressed in the larval CNS.
stan protein is detected in three layers of the distal medulla at 55 hr APF.
At 24 hr APF stan protein is strongly in the growth cones of photoreceptor cells R1-R6, and weakly expressed in neuronal cell bodies in the lamina. At 30 hr APF, stan is expressed unevenly in the growth cones of photoreceptor cells R1-R6 in the lamina plexus. By 46 hr APF, stan can no longer be detected in the growth cones or axons of photoreceptors. This expression pattern coincides with growth cone target selection. stan protein is also transiently expressed in photoreceptor cell R8 axons as they enter the optic lobe.
In third instar larvae, protein is strongly expressed in the lamina plexus where R1-R6 axons terminate and in the area of the medulla in which R7 and R8 axons terminate. Expression in photoreceptor cell axons is restricted to the growth cones. Expression was also observed in the lobula that correlates with the terminations of medullary cortical neurons. Expression in the medulla and lamina persists through pupal development with increased staining of lamina and medulla cortical neurons observed.
Between 0 and 4 hours after puparium formation protein is evenly distributed at the cell surface of apical sheath cells and does not display polarized localization.
JBrowse - Visual display of RNA-Seq signals
View Dmel\stan in JBrowse
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA has been made from templates generated with primers directed against this gene. stan RNAi results in overextension of ddaD and ddaE dendrites.
Identification: 1 allele of stan have been identified in a screen to isolate genes required for normal neuronal morphogenesis in larval mushroom body neurons.
Mutations in stan alter the polarity of cuticular structures in all regions of the adult body, affecting epidermal hairs, sensory bristles and ommatidia.
stan has a function in dendritic development.
Identification: identified as a mutant in which photoreceptor axons make aberrant projection patterns in mutant clones in the eye.
stan has an essential role in the formation of axon tracts, and controls planar cell polarity at epithelial cell-cell boundaries.
Source for merge of: stan fmi
stan was named 'starry night' after the swirling brush strokes in the eponymous painting by Van Gogh.
Named flamingo after the molecular appearance of the protein.
