FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\dom
Open Close
General Information
Symbol
Dmel\dom
Species
D. melanogaster
Name
domino
Annotation Symbol
CG9696
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020306
Gene Model Status
Current
Stock Availability
38 publicly available
Gene Summary
domino (dom) encodes a protein of the SWI2/SNF2 class of DNA-dependent ATPases. It is a component of the Tip60 acetyltransferase complex and functions in the exchange of histone His2Av. dom product contributes to Notch signaling and cell death regulation, as well as numerous other processes. [Date last reviewed: 2018-10-04] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DOM-A

Key Links
Genomic Location
Cytogenetic map
57D11-57D12
Sequence location
Recombination map
2-94
RefSeq locus
NT_033778 REGION:21323430..21341847
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (26 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables ATP-dependent H2AZ histone chaperone activity
inferred from mutant phenotype
(Scacchetti et al., 2020, Börner and Becker, 2016)
enables histone chaperone activity
inferred from direct assay
(Kusch et al., 2004)
enables protein binding
inferred from physical interaction with FLYBASE:E2f1; FB:FBgn0011766
(Lu et al., 2007)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000330
(InterPro Project Members, 2004-)
enables ATP hydrolysis activity
inferred from biological aspect of ancestor with PANTHER:PTN002904112
(GO Reference Genome Project, 2011-)
enables ATP-dependent activity, acting on DNA
inferred from sequence or structural similarity with FLYBASE:brm; FB:FBgn0000212
(Ruhf et al., 2001)
inferred from sequence or structural similarity with UniProtKB:P51532
(Ruhf et al., 2001)
enables histone binding
inferred from biological aspect of ancestor with PANTHER:PTN002904112
(GO Reference Genome Project, 2011-)
Biological Process (15 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
involved_in chromatin organization
inferred from mutant phenotype
(Ruhf et al., 2001)
involved_in chromatin remodeling
inferred from mutant phenotype
(Börner and Becker, 2016)
involved_in dendrite guidance
inferred from mutant phenotype
(Tea and Luo, 2011)
involved_in dendrite morphogenesis
inferred from mutant phenotype
(Iyer et al., 2013)
involved_in DNA repair-dependent chromatin remodeling
inferred from direct assay
(Kusch et al., 2004)
involved_in male germ-line stem cell population maintenance
inferred from mutant phenotype
(Morillo Prado et al., 2013)
involved_in negative regulation of gene expression
inferred from mutant phenotype
(Lu et al., 2007)
involved_in nervous system development
inferred from mutant phenotype
(Luo et al., 2025)
involved_in oogenesis
inferred from mutant phenotype
(Börner and Becker, 2016)
involved_in regulation of alternative mRNA splicing, via spliceosome
inferred from high throughput mutant phenotype
(Park et al., 2004)
involved_in somatic stem cell population maintenance
inferred from mutant phenotype
(Morillo Prado et al., 2013)
involved_in transcription initiation-coupled chromatin remodeling
inferred from mutant phenotype
(Scacchetti et al., 2020)
involved_in wing disc pattern formation
inferred from genetic interaction with FLYBASE:mam; FB:FBgn0002643
(Gause et al., 2006)
inferred from genetic interaction with FLYBASE:N; FB:FBgn0004647
(Gause et al., 2006)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in chromatin remodeling
inferred from biological aspect of ancestor with PANTHER:PTN002904112
(GO Reference Genome Project, 2011-)
involved_in hemopoiesis
traceable author statement
(Evans et al., 2003)
involved_in negative regulation of hemocyte proliferation
traceable author statement
(Evans et al., 2003)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
part_of histone acetyltransferase complex
inferred from physical interaction with FLYBASE:pont; FB:FBgn0040078
(Kusch et al., 2004)
part_of NuA4 histone acetyltransferase complex
inferred from direct assay
(Scacchetti et al., 2020, Kusch et al., 2004)
located_in nucleus
inferred from direct assay
(Kusch et al., 2004, Ruhf et al., 2001)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in nucleus
inferred by curator from GO:0000381
(Park et al., 2004)
part_of Swr1 complex
inferred from biological aspect of ancestor with PANTHER:PTN000084261
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (Q9NDJ2)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
ATP hydrolysis activity
RHEA 13065:
Summaries
Gene Snapshot
domino (dom) encodes a protein of the SWI2/SNF2 class of DNA-dependent ATPases. It is a component of the Tip60 acetyltransferase complex and functions in the exchange of histone His2Av. dom product contributes to Notch signaling and cell death regulation, as well as numerous other processes. [Date last reviewed: 2018-10-04]
Gene Group (FlyBase)
TIP60 COMPLEX -
The Tip60 chromatin remodeling complex acetylates nucleosomal phospho-histone H2Av and exchanges it with unmodified H2Av. (Adapted from FBrf0185742).
SNF2-LIKE CHROMATIN REMODELERS -
Snf2-like chromatin remodelers are a family of helicase-like proteins that direct energy derived from ATP hydrolysis into the mechanical remodelling of chromatin structure. They are so-called due to the presence of a domain homologous to the helicase-like ATPase domain of the S. cerevisiae Snf2 protein. This domain, the Snf2 domain, consists of two tandem RecA-like folds and contains seven conserved helicase-related sequence motifs that classify it as part of the helicase superfamily 2 (SF2). However, Snf2 proteins are not bona fide helicases, lacking the ability to separate nucleic acid strands. Instead, Snf2 proteins are DNA translocases that apply an ATP-dependent torsional strain to DNA, which provides the necessary force to remodel nucleosomes or in some cases other DNA-protein complexes. (Adapted from PMID:21862382.)
SWR1 COMPLEX -
In D.mel, the SWR1 complex is an ATP-dependent histone exchanger that incorporates the histone H2A variant, His2Av. (Adapted from FBrf0245697.)
Protein Function (UniProtKB)
Component of the Tip60 chromatin-remodeling complex that upon induction of DNA double-strand breaks, mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling (PubMed:11262242, PubMed:15528408, PubMed:16508010). Involved in Notch signaling (PubMed:16024792, PubMed:16508010). Involved in oogenesis (PubMed:11262242). Plays a role in the development of the nervous system (PubMed:39708813). Required for repression of E2F target genes (PubMed:17517653). Required for somatic stem cell self-renewal but not for germline stem cell self-renewal (PubMed:16322456).
(UniProt, Q9NDJ2)
Summary (Interactive Fly)

DNA helicase/adenosine triphosphatase - component of the Tip60 chromatin-remodeling complex that acetylates nucleosomal phospho-H2Av and exchanges it with an un modified H2Av

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\dom for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9NDJ2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
dom-RA
FBtr0071603
NM_080094
10521
3198
dom-RD
FBtr0071602
NM_166446
10178
3183
dom-RE
FBtr0071604
NM_176244
8619
2497
dom-RG
FBtr0342890
NM_001299747
10626
3233
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
dom-PA
FBpp0071529
350.2
3198
9.37
Q9NDJ2
NP_524833
AAM70871
dom-PD
FBpp0071528
348.4
3183
9.26
Q8MLW2
NP_726065
AAM70870
dom-PE
FBpp0071530
274.6
2497
6.32
NP_788424
AAM70872
dom-PG
FBpp0309691
353.7
3233
9.43
A0A0B4LFX8
NP_001286676
AHN56471
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the Tip60 chromatin-remodeling complex which contains dom/Domino, Tip60, Tra1, Brd8, E(Pc), DMAP1, pont, rept, Ing3, Act87E, Bap55, MRG15, MrgBP, Gas41 and YL-1.

(UniProt, Q9NDJ2)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dom using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.56

Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
(Arbeitman et al., 2004)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism

Comment: 0-24 hr AEL; doublet

(Ruhf et al., 2001)
third instar larval stage
organism | faint

Comment: doublet

(Ruhf et al., 2001)
P-stage
organism

Comment: doublet

(Ruhf et al., 2001)
adult stage | female
germline cell
(Arbeitman et al., 2004)
organism

Comment: absent in males; doublet

(Ruhf et al., 2001)
ovary

Comment: doublet

(Ruhf et al., 2001)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
• nucleus

Comment: present in all cells; specific to dom-PB

(Ruhf et al., 2001)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 17
somatic cell
• nucleus

Comment: present in all cells; specific to dom-PB

(Ruhf et al., 2001)
embryonic stage 11 -- 17
presumptive embryonic/larval central nervous system
• nucleus

Comment: specific to dom-PA and dom-PD isoforms

(Ruhf et al., 2001)
embryonic stage 13 -- 17
presumptive embryonic/larval peripheral nervous system
• nucleus

Comment: specific to dom-PA and dom-PD isoforms

(Ruhf et al., 2001)
third instar larval stage
adult optic lobe | restricted
• nucleus

Comment: specific to dom-PA and dom-PD isoforms

(Ruhf et al., 2001)
larval ventral nerve cord | restricted
• nucleus

Comment: specific to dom-PA and dom-PD isoforms

(Ruhf et al., 2001)
sensory mother cell of imaginal disc
• nucleus

Comment: specific to dom-PA and dom-PD isoforms

(Ruhf et al., 2001)
ommatidial precursor cluster of eye disc posterior to the morphogenetic furrow
• nucleus

Comment: specific to dom-PA and dom-PD isoforms

(Ruhf et al., 2001)
larval central nervous system
• nucleus

Comment: present in all cells; specific to dom-PB

(Ruhf et al., 2001)
imaginal disc
• nucleus

Comment: present in all cells; specific to dom-PB

(Ruhf et al., 2001)
embryonic/larval lymph gland
(Ruhf et al., 2001)
embryonic/larval salivary gland
• nucleus

Comment: present in all cells; specific to dom-PB

(Ruhf et al., 2001)
adult stage | female
nurse cell
• nucleus

Comment: present in all cells; specific to dom-PB

(Ruhf et al., 2001)
follicle cell
• nucleus

Comment: present in all cells; specific to dom-PB

(Ruhf et al., 2001)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 15
organism

Comment: 0-12 hr AEL

(Ruhf et al., 2001)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of histone acetyltransferase complex
inferred from physical interaction with FLYBASE:pont; FB:FBgn0040078
(Kusch et al., 2004)
part_of NuA4 histone acetyltransferase complex
inferred from direct assay
(Scacchetti et al., 2020, Kusch et al., 2004)
located_in nucleus
inferred from direct assay
(Kusch et al., 2004, Ruhf et al., 2001)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dom in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 33 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 26 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dom
Transgenic constructs containing regulatory region of dom
Aberrations (Deficiencies and Duplications) ( 11 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | somatic clone
lethal, with Scer\GAL4Act5C.PI
lethal, with Scer\GAL4da.G32
lethal, with Scer\GAL4insc-Mz1407
lethal, with Scer\GAL4VP16.otu
lethal (with Df(2R)AA21)
lethal | female limited, with Scer\GAL4dome-PG14
lethal | germline clone | maternal effect
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal | recessive
lethal - all die before end of larval stage, with Scer\GAL4Tub.PU
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage | recessive
lethal - all die during P-stage
lethal - all die during P-stage, with Scer\GAL4Act5C.PI
partially lethal (with dom7)
partially lethal (with dom9)
partially lethal (with dom10)
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
partially lethal - majority die | recessive
partially lethal - majority live | somatic clone
viable
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-fertile, with Scer\GAL4VP16.mat.αTub67C
female semi-sterile, with Scer\GAL4C587
female semi-sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
female sterile, with Scer\GAL4C587
female sterile, with Scer\GAL4tj.PU
female sterile (with dom7)
female sterile (with dom9)
female sterile (with dom10)
female sterile | germline clone | recessive
female sterile | recessive
fertile
male fertile
Other Phenotypes
Allele
abnormal circadian behavior, with Scer\GAL4P2.4.Pdf
abnormal circadian behavior, with Scer\GAL4P2.4.Pdf, Scer\GAL80Pdf.PS
abnormal circadian behavior, with Scer\GAL4tim.PE
abnormal circadian behavior, with Scer\GAL4tim.PE, Scer\GAL80Pdf.PS
abnormal cytokinesis | spermatogenesis, with Scer\GAL4VP16.bam
abnormal immune response
abnormal neuroanatomy, with Scer\GAL4221
abnormal neuroanatomy, with Scer\GAL4ppk.1.9
abnormal neuroanatomy | adult stage, with Scer\GAL4P2.4.Pdf
abnormal neuroanatomy | adult stage, with Scer\GAL4tim.PE
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
abnormal neuroanatomy | recessive
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
decreased cell number | adult stage, with Scer\GAL4P2.4.Pdf
decreased cell number | adult stage, with Scer\GAL4tim.PE
decreased cell number | adult stage, with Scer\GAL4Tk.PS
decreased cell number | recessive
decreased size | adult stage, with Scer\GAL4ey.PU
increased cell death, with Scer\GAL4bbg-C96
majority die during embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
short lived, with Scer\GAL4Switch1.106
some die during larval stage | recessive
some die during pupal stage
some die during pupal stage | recessive
suppressor of variegation | dominant, with In(1)wm4
suppressor of variegation | dominant, with In(1)wm4h
suppressor of variegation | dominant, with P{hsp26-pt-T}39C-4
visible, with Scer\GAL4bbg-C96
visible, with Scer\GAL4bbg-C96, dom3
visible, with Scer\GAL4bbg-C96, dom9
visible, with Scer\GAL4bbg-C96, domEP2371
visible, with Scer\GAL4bbg-C96, domJF01502
visible, with Scer\GAL4bbg-C96, domk08108
visible, with Scer\GAL4bbg-C96, domRNAi.Sym.UAS
visible, with Scer\GAL4bbg-C96, domRNAi.UAS.cUa
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4ptc.PU
visible, with Scer\GAL4vg.PU
visible (with dom7)
visible (with dom10)
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage, with Scer\GAL4ey.PU
visible | adult stage, with Scer\GAL4GMR.PF
visible | adult stage, with Scer\GAL4nub.PK
visible | cold sensitive, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4ppk.1.9
adult antennal lobe projection neuron DL1 adPN
adult anterior midgut, with Scer\GAL4Tk.PS
adult enteroendocrine cell | decreased number, with Scer\GAL4Tk.PS
adult head bristle, with Scer\GAL4ptc.PU
adult s-LNv neuron | adult stage, with Scer\GAL4tim.PE
anterior crossvein, with Scer\GAL4ptc.PU
chromatin | spermatogenesis, with Scer\GAL4VP16.bam
egg, with Scer\GAL4VP16.mat.αTub67C
egg chamber, with Scer\GAL4C587
egg chamber, with Scer\GAL4tj.PU
egg chamber, with Scer\GAL4VP16.mat.αTub67C
egg chamber, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
embryonic/larval fat body | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
embryonic/larval hemocyte
embryonic/larval lymph gland
embryonic/larval plasmatocyte
embryonic/larval salivary gland | third instar larval stage, with Scer\GAL4Tub.PU
extracellular matrix | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4ey.PU
eye, with Scer\GAL4GMR.PF
female germline cyst, with Scer\GAL4C587
female germline cyst, with Scer\GAL4tj.PU
female germline cyst, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
follicle stem cell | somatic clone
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
germarium, with Scer\GAL4C587
germarium, with Scer\GAL4tj.PU
germarium | adult stage, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
hemocyte
imaginal disc
imaginal ring
larval dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
larval dorsal multidendritic neuron ddaD, with Scer\GAL4221
larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
larval s-LNv neuron, with Scer\GAL4tim.PE
larval ventral multidendritic neuron vdaB, with Scer\GAL4ppk.1.9
lipid droplet | adult stage, with Scer\GAL4Tk.PS
l-LNv neuron | adult stage, with Scer\GAL4P2.4.Pdf
l-LNv neuron | adult stage, with Scer\GAL4tim.PE
male germline stem cell | somatic clone
meiotic spindle | spermatogenesis, with Scer\GAL4VP16.bam
meiotic spindle pole | increased number | spermatogenesis, with Scer\GAL4VP16.bam
mesonotum, with Scer\GAL4pnr-MD237
midgut imaginal island
neuroblast
neuron projection | adult stage, with Scer\GAL4P2.4.Pdf
nurse cell, with Scer\GAL4VP16.mat.αTub67C
ocellus, with Scer\GAL4ptc.PU
ovariole, with Scer\GAL4C587
ovariole, with Scer\GAL4tj.PU
ovary | adult stage, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
polytene chromosome | third instar larval stage, with Scer\GAL4Tub.PU
prohemocyte
pupal s-LNv neuron, with Scer\GAL4tim.PE
tarsal segment, with Scer\GAL4dpp.blk1
testis | somatic clone
trichogen cell, with Scer\GAL4pnr-MD237
wing
wing, with Scer\GAL4bbg-C96
wing, with Scer\GAL4Bx-MS1096
wing (with dom7)
wing (with dom10)
wing | cold sensitive, with Scer\GAL4Bx-MS1096
wing disc, with Scer\GAL4bbg-C96
wing margin, with Scer\GAL4bbg-C96
wing margin, with Scer\GAL4bbg-C96, dom3
wing margin, with Scer\GAL4bbg-C96, dom9
wing margin, with Scer\GAL4bbg-C96, domEP2371
wing margin, with Scer\GAL4bbg-C96, domJF01502
wing margin, with Scer\GAL4bbg-C96, domk08108
wing margin, with Scer\GAL4bbg-C96, domRNAi.Sym.UAS
wing margin, with Scer\GAL4bbg-C96, domRNAi.UAS.cUa
wing margin, with Scer\GAL4vg.PU
wing vein, with Scer\GAL4nub.PK
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (41)
Hsap\SRCAP
9 of 14
Yes
Yes
 
5  
Hsap\EP400
5 of 14
No
Yes
1  
Hsap\ANP32A
1 of 14
No
No
Hsap\ANP32B
1 of 14
No
No
Hsap\ANP32C
1 of 14
No
No
Hsap\ANP32D
1 of 14
No
No
Hsap\ANP32E
1 of 14
No
No
Hsap\ATRX
1 of 14
No
No
Hsap\CHD6
1 of 14
No
No
Hsap\CHD7
1 of 14
No
No
1  
Hsap\CHD8
1 of 14
No
No
Hsap\CHD9
1 of 14
No
No
Hsap\CNTRL
1 of 14
No
No
Hsap\DNAAF1
1 of 14
No
No
Hsap\DNAAF11
1 of 14
No
No
Hsap\DRC3
1 of 14
No
No
Hsap\EP400P1
1 of 14
No
Yes
Hsap\ERCC6
1 of 14
No
Yes
Hsap\ERCC6L
1 of 14
No
Yes
Hsap\FSBP
1 of 14
No
No
1  
Hsap\HLTF
1 of 14
No
No
Hsap\IBSP
1 of 14
No
Yes
Hsap\INO80
1 of 14
No
No
1  
Hsap\LRRC61
1 of 14
No
No
Hsap\LRRCC1
1 of 14
No
No
Hsap\MIER1
1 of 14
No
No
1  
Hsap\MIER2
1 of 14
No
No
Hsap\MIER3
1 of 14
No
No
Hsap\NCL
1 of 14
No
No
Hsap\PUF60
1 of 14
No
No
Hsap\RAD54B
1 of 14
No
No
Hsap\RAD54L2
1 of 14
No
No
Hsap\RAD54L
1 of 14
No
No
Hsap\RBM23
1 of 14
No
No
Hsap\RBM39
1 of 14
No
No
Hsap\SART3
1 of 14
No
No
Hsap\SMARCAD1
1 of 14
No
No
Hsap\SNRPA1
1 of 14
No
No
2  
Hsap\TTF2
1 of 14
No
No
Hsap\UNC79
1 of 14
No
No
Hsap\ZC3H15
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (23)
Rnor\Srcap
8 of 14
Yes
Yes
Rnor\Ep400
7 of 14
No
Yes
Rnor\Ino80
2 of 14
No
No
Rnor\Anp32a
1 of 14
No
No
Rnor\Anp32b
1 of 14
No
No
Rnor\Anp32e
1 of 14
No
No
Rnor\Ctr9
1 of 14
No
No
Rnor\Dnaaf1
1 of 14
No
No
Rnor\Drc3
1 of 14
No
No
Rnor\Hltf
1 of 14
No
No
Rnor\Mier1
1 of 14
No
No
Rnor\Mier2
1 of 14
No
No
Rnor\Mier3
1 of 14
No
No
Rnor\Ncl
1 of 14
No
No
Rnor\Pkd1l3
1 of 14
No
No
Rnor\Puf60
1 of 14
No
No
Rnor\Rbm34
1 of 14
No
No
Rnor\Rbm39
1 of 14
No
No
Rnor\RGD1564243
1 of 14
No
No
Rnor\Sbp
1 of 14
No
Yes
Rnor\Ttf2
1 of 14
No
No
Rnor\Zc3h15
1 of 14
No
No
Rnor\Zg16b
1 of 14
No
Yes
Mus musculus (laboratory mouse) (23)
Mmus\Ep400
8 of 14
Yes
Yes
Mmus\Srcap
8 of 14
Yes
Yes
Mmus\Anp32a
1 of 14
No
No
Mmus\Anp32b
1 of 14
No
No
Mmus\Anp32e
1 of 14
No
No
Mmus\Anp32-ps
1 of 14
No
No
Mmus\Dnaaf1
1 of 14
No
No
Mmus\Drc3
1 of 14
No
No
Mmus\Hltf
1 of 14
No
No
Mmus\Ino80
1 of 14
No
No
Mmus\Lrrc6
1 of 14
No
No
Mmus\Mdn1
1 of 14
No
No
Mmus\Mier1
1 of 14
No
No
Mmus\Mier2
1 of 14
No
No
Mmus\Mier3
1 of 14
No
No
Mmus\Ncl
1 of 14
No
No
Mmus\Puf60
1 of 14
No
No
Mmus\Rbm34
1 of 14
No
No
Mmus\Rbm39
1 of 14
No
No
Mmus\Sbpl
1 of 14
No
Yes
Mmus\Sbp
1 of 14
No
Yes
Mmus\Ttf2
1 of 14
No
No
Mmus\Zc3h15
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (44)
Xtro\ep400
4 of 13
Yes
Yes
Xtro\LOC100145162
4 of 13
Yes
Yes
Xtro\srcap
4 of 13
Yes
Yes
Xtro\ino80
2 of 13
No
No
Xtro\akap7
1 of 13
No
Yes
Xtro\anp32a
1 of 13
No
No
Xtro\anp32b
1 of 13
No
No
Xtro\cep97
1 of 13
No
No
Xtro\chd3
1 of 13
No
No
Xtro\chd6
1 of 13
No
No
Xtro\chd7
1 of 13
No
No
Xtro\chd8
1 of 13
No
No
Xtro\chd9
1 of 13
No
No
Xtro\cntrl
1 of 13
No
No
Xtro\cyb561d1
1 of 13
No
No
Xtro\dnaaf1
1 of 13
No
No
Xtro\dnaaf11
1 of 13
No
No
Xtro\drc3
1 of 13
No
No
Xtro\ercc6l
1 of 13
No
Yes
Xtro\ercc6
1 of 13
No
Yes
Xtro\hells
1 of 13
No
No
Xtro\LOC100485294
1 of 13
No
No
Xtro\LOC100487485
1 of 13
No
No
Xtro\LOC100492632
1 of 13
No
No
Xtro\LOC100496436
1 of 13
No
No
Xtro\LOC100497915
1 of 13
No
No
Xtro\LOC100498072
1 of 13
No
No
Xtro\LOC100498329
1 of 13
No
No
Xtro\LOC100498553
1 of 13
No
No
Xtro\LOC100498647
1 of 13
No
No
Xtro\LOC101730940
1 of 13
No
No
Xtro\LOC101734862
1 of 13
No
No
Xtro\lrtomt
1 of 13
No
No
Xtro\mdn1
1 of 13
No
No
Xtro\mga
1 of 13
No
No
Xtro\mier2
1 of 13
No
No
Xtro\mier3
1 of 13
No
No
Xtro\mnat1
1 of 13
No
No
Xtro\otogl2
1 of 13
No
No
Xtro\rad54l2
1 of 13
No
No
Xtro\smarcad1
1 of 13
No
No
Xtro\tcf19
1 of 13
No
No
Xtro\zc3h15
1 of 13
No
No
Xtro\zg16
1 of 13
No
Yes
Danio rerio (Zebrafish) (30)
Drer\srcap
9 of 14
Yes
Yes
Drer\ep400
4 of 14
No
Yes
Drer\anp32a
1 of 14
No
No
Drer\anp32b
1 of 14
No
No
Drer\anp32e
1 of 14
No
No
Drer\dnaaf1
1 of 14
No
No
Drer\drc3
1 of 14
No
No
Drer\im:7138144
1 of 14
No
No
Drer\ino80
1 of 14
No
No
Drer\LOC100333146
1 of 14
No
No
Drer\LOC101885127
1 of 14
No
Yes
Drer\lrba
1 of 14
No
No
Drer\lrrc51
1 of 14
No
No
Drer\mier1a
1 of 14
No
No
Drer\mier1b
1 of 14
No
No
Drer\mier2
1 of 14
No
No
Drer\mier3a
1 of 14
No
No
Drer\mier3b
1 of 14
No
No
Drer\ncl
1 of 14
No
No
Drer\nipblb
1 of 14
No
No
Drer\puf60a
1 of 14
No
No
Drer\puf60b
1 of 14
No
No
Drer\rbm34
1 of 14
No
No
Drer\rbm39a
1 of 14
No
No
Drer\rbm39b
1 of 14
No
No
Drer\rnf213a
1 of 14
No
Yes
Drer\sart3
1 of 14
No
No
Drer\si:dkeyp-68b7.12
1 of 14
No
No
Drer\ttf2
1 of 14
No
No
Drer\zc3h15
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (18)
Cele\ssl-1
9 of 14
Yes
Yes
Cele\btf-1
1 of 14
No
No
Cele\csb-1
1 of 14
No
No
Cele\dcaf-1
1 of 14
No
No
Cele\F27D4.4
1 of 14
No
No
Cele\F33H2.3
1 of 14
No
No
Cele\F54E12.2
1 of 14
No
No
Cele\mog-2
1 of 14
No
No
Cele\pqn-15
1 of 14
No
No
Cele\R02F11.4
1 of 14
No
No
Cele\rad-26
1 of 14
No
No
Cele\rad-54.L
1 of 14
No
No
Cele\rbm-39
1 of 14
No
No
Cele\swsn-4
1 of 14
No
No
Cele\T19H12.2
1 of 14
No
No
Cele\T23H2.3
1 of 14
No
No
Cele\xnp-1
1 of 14
No
No
Cele\Y113G7B.12
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (24)
Agam\AgaP_AGAP006165
9 of 12
Yes
Yes
Agam\AgaP_AGAP000019
1 of 12
No
No
Agam\AgaP_AGAP000029
1 of 12
No
No
Agam\AgaP_AGAP000514
1 of 12
No
No
Agam\AgaP_AGAP002490
1 of 12
No
No
Agam\AgaP_AGAP002959
1 of 12
No
No
Agam\AgaP_AGAP003171
1 of 12
No
No
Agam\AgaP_AGAP003173
1 of 12
No
No
Agam\AgaP_AGAP005035
1 of 12
No
No
Agam\AgaP_AGAP005075
1 of 12
No
No
Agam\AgaP_AGAP005249
1 of 12
No
No
Agam\AgaP_AGAP006945
1 of 12
No
No
Agam\AgaP_AGAP007573
1 of 12
No
No
Agam\AgaP_AGAP007670
1 of 12
No
No
Agam\AgaP_AGAP008634
1 of 12
No
No
Agam\AgaP_AGAP008748
1 of 12
No
No
Agam\AgaP_AGAP008927
1 of 12
No
No
Agam\AgaP_AGAP009344
1 of 12
No
No
Agam\AgaP_AGAP009980
1 of 12
No
No
Agam\AgaP_AGAP010180
1 of 12
No
No
Agam\AgaP_AGAP011966
1 of 12
No
No
Agam\AgaP_AGAP012134
1 of 12
No
No
Agam\GPRRK
1 of 12
No
No
Agam\LRC50_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (33)
Atha\PIE1
10 of 13
Yes
Yes
Atha\AT1G05120
1 of 13
No
No
Atha\AT1G11100
1 of 13
No
No
Atha\AT1G50410
1 of 13
No
No
Atha\AT2G21440
1 of 13
No
No
Atha\AT2G27060
1 of 13
No
Yes
Atha\AT2G35410
1 of 13
No
No
Atha\AT2G40770
1 of 13
No
No
Atha\AT3G16600
1 of 13
No
No
Atha\AT3G20010
1 of 13
No
No
Atha\AT3G50690
1 of 13
No
No
Atha\AT3G54460
1 of 13
No
No
Atha\AT4G28650
1 of 13
No
Yes
Atha\AT5G03480
1 of 13
No
Yes
Atha\AT5G05130
1 of 13
No
No
Atha\AT5G43530
1 of 13
No
No
Atha\ATCHR12
1 of 13
No
No
Atha\ATRX
1 of 13
No
No
Atha\CHR1
1 of 13
No
No
Atha\CHR8
1 of 13
No
Yes
Atha\CHR24
1 of 13
No
Yes
Atha\CID9
1 of 13
No
No
Atha\EDA16
1 of 13
No
No
Atha\INO80
1 of 13
No
No
Atha\MOM
1 of 13
No
Yes
Atha\NUC-L1
1 of 13
No
No
Atha\NUC-L2
1 of 13
No
No
Atha\RAD5
1 of 13
No
No
Atha\RAD54
1 of 13
No
No
Atha\RGD3
1 of 13
No
No
Atha\RLP1
1 of 13
No
No
Atha\SWI2
1 of 13
No
Yes
Atha\U2A'
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (11)
Scer\SWR1
8 of 13
Yes
Yes
Scer\CHD1
1 of 13
No
No
Scer\ISW2
1 of 13
No
No
Scer\LEA1
1 of 13
No
No
Scer\MOT1
1 of 13
No
No
Scer\NSR1
1 of 13
No
Yes
Scer\RAD5
1 of 13
No
No
Scer\RAD16
1 of 13
No
No
Scer\RAD26
1 of 13
No
Yes
Scer\TAF7
1 of 13
No
No
Scer\ULS1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (10)
Spom\swr1
8 of 12
Yes
Yes
Spom\gar2
1 of 12
No
No
Spom\ino80
1 of 12
No
No
Spom\mep33
1 of 12
No
No
Spom\ptr1
1 of 12
No
No
Spom\rad8
1 of 12
No
No
Spom\rhp16
1 of 12
No
No
Spom\SPAC17A2.12
1 of 12
No
No
Spom\SPBC23E6.02
1 of 12
No
No
Spom\SPCC737.08
1 of 12
No
No
Escherichia coli (enterobacterium) (1)
Ecol\rapA
1 of 11
Yes
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:dom. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (27)
Ino80
4 of 13
CG4049
3 of 13
Etl1
3 of 13
lds
3 of 13
okr
3 of 13
XNP
3 of 13
brm
2 of 13
CG10445
2 of 13
Chd1
2 of 13
Chd3
2 of 13
Hel89B
2 of 13
Iswi
2 of 13
kis
2 of 13
Mi-2
2 of 13
Cep97
1 of 13
CG7376
1 of 13
CG8635
1 of 13
CG12288
1 of 13
CG13185
1 of 13
CG15208
1 of 13
mahj
1 of 13
Mapmodulin
1 of 13
Marcal1
1 of 13
Rbm13
1 of 13
tilB
1 of 13
U2af50
1 of 13
U2A
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 3 )
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    SRCAP; Snf2 related CREBBP activator protein
    model of  Floating-Harbor syndrome
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    domHMS02162
    exacerbates  acute myeloid leukemia
    modeled by Hsap\HOXA9::Hsap\NUP98WT.UAS
    (Gavory et al., 2021)
    domHMS02208
    exacerbates  cancer
    modeled by RbfHMS03004
    (Parkhitko et al., 2021)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SRCAP; Snf2 related CREBBP activator protein
    9 of 14
    611421
     
    EP400; E1A binding protein p400
    5 of 14
    606265
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Dmel gene
        Ortholog showing functional complementation
        Supporting References
        dom
        Hsap\SRCAP
        (Eissenberg et al., 2005)
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        RNA-protein
        Physical Interaction
        Assay
        References
        dom - aub
        iclip, partial RNA sequence identification
        (Ma et al., 2017)
        protein-protein
        Physical Interaction
        Assay
        References
        dom - CG12054
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        dom - CG1620
        experimental knowledge based
        (Guruharsha et al., 2011)
        dom - CG5973
        experimental knowledge based
        (Guruharsha et al., 2011)
        dom - CG8677
        anti bait coimmunoprecipitation, western blot
        (Hanai et al., 2008)
        dom - CG8745
        experimental knowledge based
        (Guruharsha et al., 2011)
        dom - DMAP1
        experimental knowledge based
        (Guruharsha et al., 2011)
        dom - E2f1
        anti bait coimmunoprecipitation, western blot
        (Lu et al., 2007)
        dom - Iswi
        anti bait coimmunoprecipitation, western blot
        (Hanai et al., 2008)
        dom - Mapmodulin
        experimental knowledge based
        (Guruharsha et al., 2011)
        dom - MrgBP
        experimental knowledge based
        (Guruharsha et al., 2011)
        dom - Su(H)
        pull down, autoradiography
        (Giaimo et al., 2018)
        dom - Tbp
        anti tag coimmunoprecipitation, anti tag western blot
        (Shen et al., 2025)
        dom - Tip60
        anti tag coimmunoprecipitation, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot
        (Scacchetti et al., 2020, Kusch et al., 2004)
        dom - Tsc1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        dom - YL-1
        experimental knowledge based
        (Guruharsha et al., 2011)
        dom - Yeti
        anti bait coimmunoprecipitation, anti tag western blot
        (Messina et al., 2014)
        dom - pont
        anti tag coimmunoprecipitation, peptide massfingerprinting, western blot
        (Kusch et al., 2004)
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        dom
        enhanceable
        Asciz
        (Ellis et al., 2015)
        dom
        enhanceable
        asf1
        (Ellis et al., 2015)
        dom
        enhanceable
        Atg1
        (Kwon et al., 2013)
        dom
        suppressible
        Atg1
        (Kwon et al., 2013)
        dom
        enhanceable
        Atg5
        (Kwon et al., 2013)
        dom
        enhanceable
        Atg6
        (Kwon et al., 2013)
        dom
        enhanceable
        Atg7
        (Kwon et al., 2013)
        dom
        enhanceable
        Atg8a
        (Kwon et al., 2013)
        dom
        enhanceable
        Atg8b
        (Kwon et al., 2013)
        dom
        enhanceable
        Atg9
        (Kwon et al., 2013)
        dom
        enhanceable
        Atg12
        (Kwon et al., 2013)
        dom
        enhanceable
        brm
        (Ellis et al., 2015)
        dom
        enhanceable
        brwl
        (Ellis et al., 2015)
        dom
        enhanceable
        Caf1-55
        (Ellis et al., 2015)
        dom
        suppressible
        CG4617
        (Ellis et al., 2015)
        dom
        enhanceable
        CG5181
        (Ellis et al., 2015)
        dom
        enhanceable
        CG7745
        (Ellis et al., 2015)
        dom
        enhanceable
        CG8289
        (Ellis et al., 2015)
        dom
        enhanceable
        CG8924
        (Ellis et al., 2015)
        dom
        enhanceable
        CG11723
        (Ellis et al., 2015)
        dom
        enhanceable
        CG17385
        (Ellis et al., 2015)
        dom
        enhanceable
        Chd1
        (Ellis et al., 2015)
        dom
        suppressible
        dco
        (Kwon et al., 2013)
        dom
        enhanceable
        dco
        (Kwon et al., 2013)
        dom
        enhanceable
        Delta
        (Kwon et al., 2013)
        dom
        enhanceable
        E(Pc)
        (Kwon et al., 2013)
        dom
        enhanceable
        EcR
        (Kwon et al., 2013)
        dom
        enhanceable
        emc
        (Kwon et al., 2013)
        dom
        enhanceable
        ERR
        (Ellis et al., 2015)
        dom
        suppressible
        Etl1
        (Ellis et al., 2015)
        dom
        suppressible
        foxo
        (Martínez Corrales et al., 2022)
        dom
        enhanceable
        Gcn5
        (Ellis et al., 2015)
        dom
        suppressible
        HDAC1
        (Ellis et al., 2015)
        dom
        enhanceable
        Hel89B
        (Ellis et al., 2015)
        dom
        enhanceable
        HP1c
        (Ellis et al., 2015)
        dom
        enhanceable
        Ino80
        (Ellis et al., 2015)
        dom
        enhanceable
        Iswi
        (Ellis et al., 2015)
        dom
        enhanceable
        jigr1
        (Ellis et al., 2015)
        dom
        suppressible
        kis
        (Ellis et al., 2015)
        dom
        enhanceable
        lilli
        (Kwon et al., 2013)
        dom
        enhanceable
        Lk6
        (Kwon et al., 2013)
        dom
        enhanceable
        lola
        (Kwon et al., 2013)
        dom
        enhanceable
        M1BP
        (Ellis et al., 2015)
        dom
        suppressible
        maf-S
        (Ellis et al., 2015)
        dom
        enhanceable
        mam
        (Kwon et al., 2013)
        dom
        suppressible
        Marcal1
        (Ellis et al., 2015)
        dom
        enhanceable
        Mi-2
        (Ellis et al., 2015)
        dom
        enhanceable
        MRG15
        (Kwon et al., 2013)
        dom
        enhanceable
        mts
        (Kwon et al., 2013)
        dom
        enhanceable
        N
        (Kwon et al., 2013)
        dom
        suppressible
        N
        (Kwon et al., 2013)
        dom
        enhanceable
        Nipped-A
        (Kwon et al., 2013)
        dom
        suppressible
        Nup50
        (Ellis et al., 2015)
        dom
        enhanceable
        Pabp2
        (Kwon et al., 2013)
        dom
        enhanceable
        PCNA
        (Ellis et al., 2015)
        dom
        enhanceable
        Pp2A-29B
        (Kwon et al., 2013)
        dom
        enhanceable
        pum
        (Kwon et al., 2013)
        dom
        enhanceable
        rept
        (Kwon et al., 2013)
        dom
        enhanceable
        RpS9
        (Ellis et al., 2015)
        dom
        suppressible
        RYBP
        (Ellis et al., 2015)
        dom
        enhanceable
        sno
        (Kwon et al., 2013)
        dom
        suppressible
        tara
        (Kwon et al., 2013)
        dom
        enhanceable
        Tip60
        (Kwon et al., 2013)
        dom
        enhanceable
        Top1
        (Ellis et al., 2015)
        dom
        enhanceable
        Tudor-SN
        (Kwon et al., 2013)
        dom
        enhanceable
        tws
        (Kwon et al., 2013)
        dom
        enhanceable
        wdb
        (Kwon et al., 2013)
        dom
        suppressible
        wdb
        (Kwon et al., 2013)
        dom
        enhanceable
        wrd
        (Kwon et al., 2013)
        dom
        enhanceable
        XNP
        (Ellis et al., 2015)
        dom
        suppressible
        Zif
        (Ellis et al., 2015)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        ash1
        suppressible
        dom
        (Ruhf et al., 2001)
        brm
        suppressible
        dom
        (Ruhf et al., 2001)
        E(z)
        enhanceable
        dom
        (Ruhf et al., 2001)
        foxo
        suppressible
        dom
        (Martínez Corrales et al., 2022)
        His2Av
        enhanceable
        dom
        (Morillo Prado et al., 2013)
        mam
        enhanceable
        dom
        (Gause et al., 2006)
        mxc
        enhanceable
        dom
        (Ruhf et al., 2001)
        N
        enhanceable
        dom
        (Gause et al., 2006, Eissenberg et al., 2005)
        N
        suppressible
        dom
        (Gause et al., 2006)
        Pc
        enhanceable
        dom
        (Ruhf et al., 2001)
        peb
        suppressible
        dom
        (Wilk et al., 2004)
        ph-p
        enhanceable
        dom
        (Ruhf et al., 2001)
        RacGAP84C
        enhanceable
        dom
        (Raymond et al., 2004)
        Rbf
        enhanceable
        dom
        (Kwon et al., 2013)
        trx
        suppressible
        dom
        (Ruhf et al., 2001)
        trx|brm
        suppressible
        dom
        (Ruhf et al., 2001)
        trx|ash1
        suppressible
        dom
        (Ruhf et al., 2001)
        External Data
        Subunit Structure (UniProtKB)
        Component of the Tip60 chromatin-remodeling complex which contains dom/Domino, Tip60, Tra1, Brd8, E(Pc), DMAP1, pont, rept, Ing3, Act87E, Bap55, MRG15, MrgBP, Gas41 and YL-1.
        (UniProt, Q9NDJ2 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-94
        Cytogenetic map
        57D11-57D12
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        57D11-57D12
        Limits computationally determined from genome sequence between P{EP}CG30394EP962&P{lacW}domk08108 and P{PZ}tmx1&P{EP}MESK2EP2347
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        57E1-57E2
        (Ruhf, 1998.7.6)
        57D11-57D12
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        57E1-57E2
        (determined by in situ hybridisation)
        (Braun et al., 1997, Braun et al., 1997)
        57D11-57D12
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        2-94

        (FlyBase, 2016)

        2-101.3

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (38)
        Genomic Clones (17)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (96)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Scacchetti et al., 2020, Ruhf et al., 2001)

        monoclonal

        (Börner and Becker, 2016)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
          Other Comments

          The dom A and B protein isoforms have non-redundant functions in the germline and soma for egg formation. DOM-A promotes the removal of His2Av protein from stage 5 nurse cells, whereas DOM-B is required for chromatin incorporation of His2Av protein in germline and somatic cells.

          (Börner and Becker, 2016)

          dsRNA made from templates generated with primers directed against this gene was tested in an RNAi screen to identify genes that regulate Ca2+ release.

          (Zhang et al., 2006)

          Nitric oxide dependent activity of Dpt production in fact bodies require the function of dom.

          (Foley and O'Farrell, 2003)

          The dom products function as global transcriptional regulators via interactions with heterochromatin.

          (Ruhf et al., 2001)

          Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology.

          (Roch et al., 1998)

          Identified as a P-element induced mutant devoid of circulating hemocytes in the third instar larva.

          (Braun et al., 1997)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: domino CG9696

          (Misra, 2000.8.9)

          Source for merge of: dom anon-WO0172774.190

          (FlyBase, 1996-)
          Additional comments

          Source for merge of dom anon-WO0172774.190 was sequence comparison ( date:051113 ).

          (FlyBase, 1996-)
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (19)
          Reported As
          Symbol Synonym
          27/4
          (Roch et al., 1998)
          CG9696
          (Choudhury et al., 2024, National Institute of Genetics Fly Stocks, 2023-, National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Perkins et al., 2009, Schneiderman et al., 2009, Chen et al., 2008, Doheny et al., 2008, Ni et al., 2008, Grieder et al., 2007, McIntyre et al., 2006, Huang et al., 2005, Klebes et al., 2005, Arbeitman et al., 2004, Huang et al., 2004, Kusch et al., 2004, Eisberg, 2001.7.11, Mount, 2001.8.14)
          DOM
          (Santopietro et al., 2025, Scacchetti et al., 2020, Fukuyama et al., 2013)
          DOM-A
          (Messina et al., 2021, Messina et al., 2014, Bouazoune and Brehm, 2006)
          Dom
          (Prozzillo et al., 2021, Han et al., 2020, Honti et al., 2014, Wang et al., 2014, Kounatidis and Ligoxygakis, 2012, Lu et al., 2007, Kaeser and Emerson, 2006, Kim et al., 2005, Kruger, 2005, Huang et al., 2004)
          DomA
          (Kusch et al., 2004)
          Domino
          (Vidaurre and Chen, 2021, Giaimo et al., 2018, Clapier and Cairns, 2009, Kusch et al., 2004)
          EP400
          (Shen et al., 2025)
          anon-WO0172774.190
          dDom
          (Goodman et al., 2019)
          dEP400
          (Yasunaga et al., 2014)
          dom
          (Dyson et al., 2025, Camilleri-Robles et al., 2024, Collins et al., 2024, Peng et al., 2024, Sood et al., 2024, Escobedo et al., 2023, Yheskel et al., 2023, Marcogliese et al., 2022, Saha et al., 2022, Anqueira-González et al., 2021, Gavory et al., 2021, Parkhitko et al., 2021, Rivas et al., 2021, Sureka and Mishra, 2021, Bailetti et al., 2019, Banerjee et al., 2019, Chai et al., 2019, Zirin et al., 2019, McCarthy et al., 2018, Rust et al., 2018, Ma et al., 2017, Stessman et al., 2017, Transgenic RNAi Project members, 2017-, Börner and Becker, 2016, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Yu et al., 2016, Angrisani et al., 2015, Dietz et al., 2015, Ellis et al., 2015, Kwong et al., 2015, Nikalayevich and Ohkura, 2015, Schertel et al., 2015, Ugrankar et al., 2015, Yan et al., 2014, Yasunaga et al., 2014, Debruhl et al., 2013, Iyer et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Morillo Prado et al., 2013, Neumüller et al., 2013, Hainaut et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kounatidis and Ligoxygakis, 2012, Rodriguez et al., 2012, Friedman et al., 2011, Kirilly et al., 2011, Tea and Luo, 2011, Walker et al., 2011, Wertheim et al., 2011, Kong et al., 2010, Wasbrough et al., 2010, Aerts et al., 2009, Christensen et al., 2009.6.15, Flaherty et al., 2009, Schneiderman et al., 2009, Chen et al., 2008, Davis et al., 2008, Rong, 2008, Zhou et al., 2008, Brennan, 2007, Buszczak et al., 2007, Goodfellow et al., 2007, Grieder et al., 2007, Xing et al., 2007, Gause et al., 2006, Janody and Treisman, 2006, McIntyre et al., 2006, Nelliot et al., 2006, Rus et al., 2006, Zhang et al., 2006, Eissenberg et al., 2005, Xi and Xie, 2005, Raymond et al., 2004)
          l(2)81/8
          (Braun et al., 1997)
          l(2)k02704
          l(2)k08108
          p400
          (Kaeser and Emerson, 2006)
          Name Synonyms
          Domino
          (Dorn and Dorn, 2015, Pressman et al., 2012, Hanai et al., 2008, Goodfellow et al., 2007, Lu et al., 2007, Zhong et al., 2007, Kaeser and Emerson, 2006, Jin, 2005, Kruger, 2005, Kruger, 2005)
          Domino-A
          (Messina et al., 2014)
          domino
          (Mehrotra and Deshpande, 2018, Perez-Perri et al., 2016, Vinayagam et al., 2016, Wang et al., 2014, Fukuyama et al., 2013, Kounatidis and Ligoxygakis, 2012, Davis et al., 2011, Neumüller et al., 2011, Tea and Luo, 2011, Walker et al., 2011, Wertheim et al., 2011, Charroux and Royet, 2009, Flaherty et al., 2009, Davis et al., 2008, Rong, 2008, Brennan et al., 2007, Wagner et al., 2007, Wagner et al., 2007, Xing et al., 2007, Zhong et al., 2007, Gause et al., 2006, Nelliot et al., 2006, Castillejo-Lopez and Häcker, 2005, Eissenberg et al., 2005, Xi and Xie, 2005, Hall et al., 2004, Raymond et al., 2004, Fellowes and Godfray, 2000, Spradling et al., 1999, Braun et al., 1998, Braun et al., 1997)
          domino DNA dependent ATPase
          (Biehs et al., 2010)
          Secondary FlyBase IDs
          • FBgn0022058
          • FBgn0024590
          • FBgn0034621
          • FBgn0046413
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 74 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          References (240)