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FB2026_01
,
released March 12, 2026
l(2)k06323, MARK, dMARK, partitioning defective-1, l(2)27C1
serine/threonine kinase involved in cell polarization during asymmetric cell division - synaptic active zone proteins are transported via mechanisms regulated by Par-1 kinase
Please see the JBrowse view of Dmel\par-1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Shares 5' UTR with upstream gene.
Gene model reviewed during 5.44
Stop-codon suppression (UGA) postulated; FBrf0216884.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.48
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
None of the polypeptides share 100% sequence identity.
938 (aa)
A large number of transcripts are produced from the par-1 gene by the use of alternative promoters, multiple 3' ends and additional alternative splicing events. The predicted proteins range from 833-1130 amino acids.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\par-1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: after fusome disappearance
par-1 protein is initially ubiquitously expressed in germline cells, but becomes localized to the presumptive oocyte after fusome disappearance, during oocyte specification. During oocyte polarization par-1 protein relocalizes from the anterior to the posterior of the developing oocyte. In stage 5 oocytes FBgn0260934:par-1 becomes tightly associated with the posterior cell cortex and does not overlap with FBgn0000163:baz @ protein.
par-1 protein localizes cortically within follicle cells at early stages of oogenesis. It is restricted to the basolateral membrane domain of the columnar epithelium in stage 10 egg chambers. The earliest germ line staining is in the fusome in the germarium. par-1 protein then localizes to the ring canals and the cortical cytoskeleton of the nurse cells. No asymmetric localization of par-1 protein is observed in the oocyte during stages 1-8 but in stage 9, a transient enrichment is observed in the anterior of the oocyte. par-1 protein then becomes progressively more concentrated at the posterior pole during stages 9 and 10.
JBrowse - Visual display of RNA-Seq signals
View Dmel\par-1 in JBrowse2-89
2-94.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells, an increase in cell size, a decrease in mitotic index and a whole range of mitotic abnormalities are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: reduced F-actin and altered cell shape. Kc167 cells show change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions.
par-1 is required early in the germline for organisation of the microtubule cytoskeleton and subsequent oocyte determination. It has a second role late in oogenesis in axis determination.
par-1 is required for the maintenance of oocyte identity.
Loss of par-1 function disrupts pole cell formation and abdominal patterning in the embryo. These defects arise from a disorganisation of the oocyte microtubule cytoskeleton.
par-1 is maternally required for gametogenesis.
Source for merge of: par-1 CG11960
Source for merge of: par-1 BcDNA:RH48823
Source for merge of: par-1 l(2)27C1
Source for merge of: par-1 anon-WO0210402.19
Source for merge of par-1 anon-WO0210402.19 was sequence comparison ( date:051113 ).
