Human Disease Model Report: cancer, multiple, NOTCH-SRC-related

General Information

Name

cancer, multiple, NOTCH-SRC-related

FlyBase ID

FBhh0001146

Disease Ontology Term

cancer

Parent Disease

OMIM

Overview

This report describes a Drosophila model of cancer that combines a constitutively activated mutation in the fly gene Notch (N) with constitutively active or over-expressing alleles of the fly genes Src42A and Src64B. Dmel\N encodes a transmembrane receptor that plays a key role in intercellular signaling; the fly gene is orthologous to 4 human genes, NOTCH1-NOTCH4. See the human disease model report 'cancer, multiple, Notch signaling pathway' (FBhh0000766).

Dmel\Src64B is the highest-scoring ortholog of human SRC; SRC encodes a non-receptor protein tyrosine kinase that participates in multiple signaling pathways involved in gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, cell migration, and transformation. SRC is overexpressed or activated in multiple human malignancies. Dmel\Src42A is a low-scoring ortholog of human SRC; it is most closely related to another human Src family tyrosine kinase, FRK. Classical loss-of-function mutations, RNAi-targeting constructs, and alleles caused by insertional mutagenesis have been generated for both fly Src genes.

None of these human genes has been introduced into flies.

Assessed in both eye discs and wing discs, a constitutively active allele of Src42A causes hyperplastic growth in combination with an activated N allele. Overexpression of Src64B in combination with activated N results in similar phenotypes. Experiments support the hypothesis that the JNK pathway regulates the majority of the phenotypes and transcriptional changes downstream of Notch-Src interactions.

See also 'cancer, intestinal stem cell, SRC-related' (FBhh0000475).

[updated Nov. 2019 by FlyBase; FBrf0222196]

Disease Summary Information

Disease Summary: cancer, multiple, NOTCH-SRC-related

OMIM report

Human gene(s) implicated

Symptoms and phenotype

Genetics

Cellular phenotype and pathology

Molecular information

FRK encodes a non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. [Gene Cards, FRK; 2019.11.12]

(FlyBase Curators, 2013-)

SRC encodes a non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. [Gene Cards, SRC; 2019.11.12]

(FlyBase Curators, 2013-)

External links

COSMIC gene: SRC
COSMIC gene: FRK
COSMIC gene: NOTCH1
Gene2Function (human gene): SRC
Gene2Function (human gene): FRK fyn related Src family tyrosine kinase
Gene Cards: SRC
Gene Cards: FRK gene
Gene Cards: FRK fyn related Src family tyrosine kinase
KEGG Disease Pathways: Pathways in Cancer
MARRVEL (human gene): FRK fyn related Src family tyrosine kinase
MARRVEL (human gene): SRC
NCBI (Entrez) gene: SRC; SRC proto-oncogene, non-receptor tyrosine kinase
NCBI (Entrez) gene: FRK fyn related Src family tyrosine kinase

Disease synonyms

Search term: hyperplastic phenotype(s)

Related Diseases

Related human health report(s)

cancer, intestinal stem cell, SRC-related

cancer, multiple, Notch signaling pathway

cancer, multiple, RAS-SRC-related

Ortholog Information

Human gene(s) in FlyBase

Other mammalian ortholog(s) used

D. melanogaster Gene Information (3)

Dmel\N

Gene Snapshot

Contributions welcome

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Moderate- to high-scoring ortholog of human NOTCH1, NOTCH2, NOTCH3, NOTCH4 (1 Drosophila to 4 human). Dmel\N shares 43-44% identity and 56-57% similarity with NOTCH1 and NOTCH2.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\Src42A

Gene Snapshot

Src oncogene at 42A (Src42A) encodes the none-receptor tyrosine kinase regulating cell proliferation, cell adhesion and morphogenetic processes including dorsal closure, tracheal tube size control and germ band elongation. It is regulated by both inhibitory and activating tyrosine phosphorylation. [Date last reviewed: 2019-09-26]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

High-scoring ortholog of human gene FRK; lower-scoring ortholog of human SRC (many to many; multiple paralogs and orthologs in both species). Dmel\Src42A shares 54% identity and 68% similarity with human FRK.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\Src64B

Gene Snapshot

Src oncogene at 64B (Src64B) encodes a Src family nonreceptor tyrosine kinase. It has many biological roles, including ring canal morphogenesis in oogenesis and the male germline, microfilament ring constriction during cellularization, and modulation of growth and apoptosis. Some of its roles overlap with those of the product of Src42A. [Date last reviewed: 2019-03-14]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Highest-scoring ortholog of human gene SRC (many to many; multiple paralogs and orthologs in both species). Dmel\Src64B shares 50% identity and 67% similarity with human SRC.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Other Genes Used: Viral, Bacterial, Synthetic (0)

Summary of Physical Interactions (91 groups)

protein-protein

Interacting group

Assay

References

two hybrid, enzyme linked immunosorbent assay

(Pei and Baker, 2008, Fortini and Artavanis-Tsakonas, 1994)

N - Abl

anti bait coimmunoprecipitation, western blot

(Koca et al., 2022)

N - Akap200

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Bala Tannan et al., 2018)

N - arm

anti bait coimmunoprecipitation, western blot

(Koca et al., 2022, Hayward et al., 2005)

N - Atg8a

proximity ligation assay, fluorescence microscopy

(Katz et al., 2025)

N - baz

anti tag coimmunoprecipitation, anti tag western blot

(Wu et al., 2024)

N - Caf1-55

anti tag coimmunoprecipitation, anti tag western blot

(Yu et al., 2013)

N - Caf1-105

anti tag coimmunoprecipitation, anti tag western blot

(Yu et al., 2013)

N - Caf1-180

anti tag coimmunoprecipitation, anti tag western blot

(Yu et al., 2013)

N - Cdk8

pull down, western blot

(Park et al., 2003)

N - CG10916

experimental knowledge based

(Guruharsha et al., 2011)

N - Chi

pull down, western blot, anti tag coimmunoprecipitation

(Sachan et al., 2015)

N - cno

two hybrid, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, autoradiography

(Pérez-Gómez et al., 2013, Carmena et al., 2006)

N - crb

proximity ligation assay, fluorescence microscopy

(Nemetschke and Knust, 2016)

N - D

affinity technology, tag visualisation by alkaline phosphatase activity

(Pérez et al., 2005)

N - Dab

pull down, autoradiography, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation

(Kannan et al., 2018, Le Gall et al., 2008, Le Gall and Giniger, 2004, Giniger, 1998)

N - Delta

anti bait coimmunoprecipitation, cross-linking study, western blot, enzyme linked immunosorbent assay, bead aggregation assay, fluorescence microscopy, inferred by author, affinity technology, atomic force microscopy, tag visualisation, tag visualisation by alkaline phosphatase activity, phenotype-based detection assay, pull down

(Pandey et al., 2019, Yamamoto et al., 2012, Acar et al., 2008, Pei and Baker, 2008, Xu et al., 2007, Parks et al., 2006, Ahimou et al., 2004, Bruckner et al., 2000, Wesley and Saez, 2000, Wesley, 1999, Rebay et al., 1991, Fehon et al., 1990)

N - dsh

pull down, western blot, anti bait coimmunoprecipitation, two hybrid, autoradiography

(Capilla et al., 2012, Muñoz-Descalzo et al., 2010, Hayward et al., 2005, Ramain et al., 2001, Axelrod et al., 1996)

N - dx

two hybrid, nuclear magnetic resonance, cosedimentation in solution, predetermined participant, anti tag coimmunoprecipitation, anti tag western blot, western blot

(Carter et al., 2023, Shimizu et al., 2014, Muñoz-Descalzo et al., 2010, Matsuno et al., 1995, Diederich et al., 1994)

N - Eip75B

anti tag coimmunoprecipitation, western blot, proximity ligation assay, fluorescence microscopy

(Wang et al., 2024)

N - Eogt

enzymatic study

(Sakaidani et al., 2011)

N - htk

two hybrid, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Singh et al., 2019)

N - Kap-α3

pull down, western blot, anti tag coimmunoprecipitation, two hybrid

(Sachan et al., 2013)

N - kuz

protease assay, western blot, inferred by author

(Pan and Rubin, 1997)

N - lilli

anti tag coimmunoprecipitation, anti tag western blot

(Liu et al., 2017)

N - mam

anti tag coimmunoprecipitation, peptide massfingerprinting, three hybrid, protein three hybrid

(Gahr et al., 2019, Nagel et al., 2017, Yuan et al., 2016, Maier et al., 2011, Veraksa et al., 2005, Petcherski and Kimble, 2000)

N - mask

two hybrid, anti bait coimmunoprecipitation, western blot

(Sarkar et al., 2025)

N - MED17

pull down, western blot

(Park et al., 2003)

N - MED21

pull down, western blot

(Park et al., 2003)

N - MED31

pull down, western blot

(Park et al., 2003)

N - msn

coimmunoprecipitation, western blot

(Mishra et al., 2015)

N - mura

anti tag coimmunoprecipitation, anti tag western blot

(Deen et al., 2025)

N - ND-30

anti tag coimmunoprecipitation, western blot

(Lee et al., 2013)

N - Nedd4

anti tag coimmunoprecipitation, western blot, pull down

(Sakata et al., 2004)

N - numb

pull down, autoradiography, two hybrid

(Guo et al., 1996)

N - Ofut1

anti tag coimmunoprecipitation, western blot, anti tag western blot

(Sasamura et al., 2007, Okajima et al., 2005)

N - Pink1

anti tag coimmunoprecipitation, western blot

(Lee et al., 2013)

N - Pngl

experimental knowledge based

(Guruharsha et al., 2011)

N - polo

experimental knowledge based

(Guruharsha et al., 2011)

N - pyd

anti tag coimmunoprecipitation, anti tag western blot

(Shimizu et al., 2017)

N - Rbfox1

anti bait coimmunoprecipitation, western blot

(Shukla et al., 2017)

N - sca

anti tag coimmunoprecipitation, western blot

(Petruccelli et al., 2018)

N - Ser

affinity technology, fluorescence microscopy, inferred by author, bead aggregation assay, tag visualisation by alkaline phosphatase activity, anti bait coimmunoprecipitation, cross-linking study, western blot, anti tag coimmunoprecipitation, confocal microscopy, pull down, tag visualisation

(Pandey et al., 2019, Fleming et al., 2013, Pérez-Gómez et al., 2013, Yamamoto et al., 2012, Kim et al., 2010, Xu et al., 2007, Pérez et al., 2005, Wesley, 1999, Rebay et al., 1991)

N - shg

anti bait coimmunoprecipitation, western blot

(Sasaki et al., 2007)

N - spdo

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, pull down

(Upadhyay et al., 2013, O'Connor-Giles and Skeath, 2003)

N - Su(dx)

pull down, molecular weight estimation by staining, isothermal titration calorimetry, predetermined participant, autoradiography, nuclear magnetic resonance, western blot

(Yao et al., 2018, Jennings et al., 2007, Wilkin et al., 2004)

N - Su(H)

isothermal titration calorimetry, predetermined participant, electron microscopy, two hybrid, protein three hybrid, pull down, autoradiography, anti tag coimmunoprecipitation, western blot, three hybrid, peptide massfingerprinting, anti bait coimmunoprecipitation, anti tag western blot, molecular sieving, molecular weight estimation by staining, coimmunoprecipitation, cosedimentation, electrophoretic mobility shift assay, electrophoretic mobility supershift assay

N - Taf9

anti tag coimmunoprecipitation, anti tag western blot

(Xie et al., 2014)

N - Traf6

two hybrid, pull down, western blot, anti tag coimmunoprecipitation

(Mishra et al., 2014)

N - trio

anti bait coimmunoprecipitation, western blot

(Kannan et al., 2018, Le Gall et al., 2008)

N - uif

anti tag coimmunoprecipitation, anti tag western blot

(Loubéry et al., 2014)

N - Vps26

anti tag coimmunoprecipitation, anti tag western blot

(Li et al., 2018)

N - Vps35

anti tag coimmunoprecipitation, anti tag western blot

(Li et al., 2018)

N - wg

anti bait coimmunoprecipitation, cross-linking study, western blot

(Wesley, 1999)

N - wry

inferred by author, confocal microscopy, bead aggregation assay

(Kim et al., 2010)

N - yki

proximity ligation assay, fluorescence microscopy

(Wang et al., 2024)

N - zip

anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry, anti tag western blot

(Verma et al., 2024)

RNA-protein

Interacting group

Assay

References

N - Sxl

nucleic acid uv cross-linking assay, autoradiography, anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Penn and Schedl, 2007)

N - TBPH

pull down, quantitative reverse transcription pcr

(Swain et al., 2016)

Src42A

protein-protein

Interacting group

Assay

References

Src42A

enzymatic study, autoradiography, western blot

(Pedraza et al., 2004, Stewart et al., 2003, Muda et al., 2002)

Src42A - 18w

anti tag coimmunoprecipitation, anti tag western blot

(Tamada et al., 2021)

Src42A - Akap200

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Src42A - Arc1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Src42A - arm

anti bait coimmunoprecipitation, western blot, pull down

(Takahashi et al., 2005)

Src42A - baz

anti tag coimmunoprecipitation, anti tag western blot

(Sotillos et al., 2013)

Src42A - Cad96Ca

pull down, anti tag western blot, two hybrid

(Tsarouhas et al., 2014)

Src42A - CadN

pull down, anti tag western blot

(Pütz, 2019)

Src42A - cnk

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, pull down

(Laberge et al., 2005)

Src42A - Csk

enzymatic study, western blot, autoradiography

(Pedraza et al., 2004, Stewart et al., 2003)

Src42A - dock

enzymatic study, autoradiography

(Muda et al., 2002)

Src42A - Dscam1

enzymatic study, autoradiography

(Muda et al., 2002)

Src42A - Egfr

two hybrid

(Bianco et al., 2007)

Src42A - Hrb87F

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Src42A - Hsp83

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Src42A - Pvr

anti tag coimmunoprecipitation, peptide massfingerprinting, two hybrid

(Friedman et al., 2011, Bianco et al., 2007)

Src42A - shg

anti bait coimmunoprecipitation, western blot

(Takahashi et al., 2005)

Src42A - smash

anti tag coimmunoprecipitation, anti tag western blot

(Beati et al., 2018)

Src42A - Sos

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Src42A - Toll-6

anti tag coimmunoprecipitation, anti tag western blot

(Tamada et al., 2021)

Src42A - wts

anti tag coimmunoprecipitation, anti tag western blot

(Ding et al., 2021)

Src64B

protein-protein

Interacting group

Assay

References

Src64B

enzymatic study, autoradiography

(Pedraza et al., 2004)

Src64B - 18w

anti tag coimmunoprecipitation, anti tag western blot

(Tamada et al., 2021)

Src64B - Cad96Ca

two hybrid, pull down, anti tag western blot

(Tsarouhas et al., 2014)

Src64B - CadN

pull down, anti tag western blot

(Pütz, 2019)

Src64B - Csk

enzymatic study, autoradiography

(Pedraza et al., 2004)

Src64B - drl

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Petrova et al., 2013, Wouda et al., 2008)

Src64B - gcm2

two hybrid

(Hu et al., 2017.6.13)

Src64B - hzg

anti tag coimmunoprecipitation, western blot, multidimensional protein identification technology

(Nil et al., 2019)

Src64B - kirre

anti tag coimmunoprecipitation, western blot

(Tutor et al., 2014)

Src64B - stumps

anti bait coimmunoprecipitation, anti tag western blot

(Csiszar et al., 2010)

Src64B - Toll-6

anti tag coimmunoprecipitation, anti tag western blot

(Tamada et al., 2021)

Alleles Reported to Model Human Disease (Disease Ontology) (41 alleles)

Models Based on Experimental Evidence ( 13 )

Allele

Disease

Evidence

References

N^DN.UAS.cUa

model of cancer

CEA with Ras85D^V12.cUa.UAS

(Lee et al., 2021)

CEA

(Lee et al., 2021, Tamamouna et al., 2021)

CEA with Ras85D^V12.UAS

(Xu et al., 2023)

model of intestinal cancer

CEA

(Singh et al., 2016)

N^ICN.UAS

model of cancer

CEA

(Wang et al., 2021, Harsh and Eleftherianos, 2020)

CEA with Mef2^UAS.cUa

(Harsh and Eleftherianos, 2020)

model of carcinoma

CEA with Mef2^UAS.cUa

(Pallavi et al., 2012)

CEA with egr^UAS.cUa

(Pallavi et al., 2012)

model of brain cancer

CEA

(Wang et al., 2006)

N^UAS.cMa

model of adenoid cystic carcinoma

CEA with Hsap\MYB^ΔC.UAS, Xpd^{RNAi.UAS.012.1}, ft^{RNAi.UAS.012.1}, kug^{RNAi.UAS.012.1}

(Bangi et al., 2021)

CEA with Hsap\MYB^ΔC.UAS, Xpd^{RNAi.UAS.012.2}, ft^{RNAi.UAS.012.2}, kug^{RNAi.UAS.012.2}

(Bangi et al., 2021)

N^UAS.icd

model of central nervous system cancer

CEA

(Zacharioudaki et al., 2016)

N^RNAi.P.UAS

model of intestinal cancer

CEA

(Chen et al., 2021)

CEA with mys^GD15002

(Chen et al., 2021)

model of cancer

CEA with Ras85D^V12.UAS

(Tamamouna et al., 2021)

N^intra.GS.UAS

model of neurodegenerative disease

CEA

(Loewen et al., 2018)

N^{UAS.Tag:V5,Tag:polyHis}

model of brain cancer

CEA

(Ojha et al., 2022)

model of cancer

CEA

(Khaket et al., 2024)

N^GD144

model of alcohol use disorder

CEA

(Petruccelli et al., 2018)

N^GD14477

model of intestinal cancer

CEA

(Banreti et al., 2022)

model of colorectal cancer

CEA

(Zipper et al., 2022)

model of cancer

CEA

(Brás et al., 2021)

N^HD_CFD01184

model of intestinal cancer

CEC with Spyo\Cas9^UAS.uM.-FRT

(Bahuguna et al., 2021)

CEC with Spyo\Cas9^UAS.P2

(Bahuguna et al., 2021)

N^CA.UAS.cUa

model of central nervous system cancer

CEA

(Magadi et al., 2020, Zacharioudaki et al., 2016)

model of carcinoma

CEA with l(2)gl^GD4047

(Jevitt et al., 2021)

model of adenocarcinoma

CEA

(Casas-Tintó et al., 2016)

CEA with wupA^f06492

(Casas-Tintó et al., 2016)

model of cervical cancer

CEA with Hsap\UBE3A^UAS.cRa, HPV18\E6^UAS.Tag:MYC

(Padash Barmchi et al., 2016)

N^RNAi.UAS.cUa

model of intestinal cancer

CEA

(Ayyaz et al., 2015)

N^ΔE.UAS

model of central nervous system cancer

CEA

(Voutyraki et al., 2023, Voutyraki et al., 2022)

Modifiers Based on Experimental Evidence ( 22 )

Allele

Disease

Interaction

References

N^DN.UAS.cUa

model of cancer

is ameliorated by wg^JF01257

(Lee et al., 2021)

is ameliorated by Atg1^UAS.cSa

(Lee et al., 2021)

ameliorates carcinoma

modeled by Vps25^N55

(Herz et al., 2006)

modeled by ph-d⁵⁰⁵, ph-p⁵⁰⁵

(Beira et al., 2018)

ameliorates intestinal cancer

modeled by yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Pranoto et al., 2023)

N^ECN.UAS

ameliorates cancer

modeled by Src64B^UAS.cCa

(Enomoto et al., 2021)

N^{FLN.ΔCdc10.UAS}

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

N^ICN.UAS

model of cancer

is ameliorated by Dref^JF02232

(Wang et al., 2021)

is ameliorated by RPA1^GL00350

(Wang et al., 2021)

is ameliorated by SMC5^HMC04343

(Wang et al., 2021)

is ameliorated by fzr^GD9960

(Wang et al., 2021)

is ameliorated by mei-41^GL00284

(Wang et al., 2021)

is ameliorated by mre11^HMC02995

(Wang et al., 2021)

is exacerbated by stg^UAS.Tag:HA

(Wang et al., 2021)

is ameliorated by stg^RNAi.UAS.cUa

(Wang et al., 2021)

is ameliorated by CycE^HMS00060

(Wang et al., 2021)

exacerbates cancer

modeled by Src64B^UAS.cCa

(Enomoto et al., 2021)

modeled by Hipk^UAS.Tag:HA

(Blaquiere et al., 2018)

exacerbates carcinoma

modeled by scrib¹

(Brumby and Richardson, 2003)

N^UAS.icd

model of central nervous system cancer

is ameliorated by hth^C1

(Zacharioudaki et al., 2016)

is exacerbated by mira^HMS00347

(Zacharioudaki et al., 2016)

is ameliorated by svp¹

(Zacharioudaki et al., 2016)

is ameliorated by hth^B2

(Zacharioudaki et al., 2016)

N^RNAi.P.UAS

model of intestinal cancer

is exacerbated by Cat^HMS00990

(Chen et al., 2021)

is ameliorated by Cat^UAS.cUa

(Chen et al., 2021)

is ameliorated by cnc^UAS.cSa

(Chen et al., 2021)

is exacerbated by Sod2^HMS00499

(Chen et al., 2021)

is exacerbated by cnc^HMS00650

(Chen et al., 2021)

is ameliorated by Sod2^UAS.cMa

(Chen et al., 2021)

ameliorates carcinoma

modeled by Vps25^A3

(Vaccari and Bilder, 2005)

N^fa-swb

ameliorates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cJa

(Rousseaux et al., 2018)

N^intra.GS.UAS

ameliorates cancer

modeled by Pvr^{λ.UASp.Tag:MYC}

(Wang et al., 2023)

exacerbates carcinoma

modeled by Nkap^GD11807

(Guo et al., 2024)

N^l1N-ts1

ameliorates brain cancer

modeled by aurA⁸⁸³⁹

(Wang et al., 2006)

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 7

modeled by Hsap\CHMP2B^Intron5.UAS

(Wilson et al., 2020)

N^nd-1

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

N^nd-3

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

N^{UAS.Tag:V5,Tag:polyHis}

model of brain cancer

is ameliorated by ND-49^HM05059

(Ojha et al., 2022)

is ameliorated by Scer\NDI1^UAS.cBa

(Ojha et al., 2022)

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

modeled by Zzzz\poly-GA^{80.UAS.Tag:FLAG}

(Li et al., 2020)

modeled by Zzzz\poly-PR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

model of cancer

is ameliorated by TER94^JF03402

(Khaket et al., 2024)

is ameliorated by CG11414^HMJ23120

(Khaket et al., 2024)

is ameliorated by Cnot4^JF03203

(Khaket et al., 2024)

is ameliorated by SARS-CoV-2\nsp1^UAS.cZa

(Khaket et al., 2024)

is ameliorated by pelo^KK101657

(Khaket et al., 2024)

is ameliorated by pelo^{UAS.ORF.GW.Tag:HA}

(Khaket et al., 2024)

is ameliorated by pix^JF01190

(Khaket et al., 2024)

is ameliorated by pix^{UAS.ORF.Tag:HA}

(Khaket et al., 2024)

N^JF01637

ameliorates carcinoma

modeled by l(2)gl^GD4047

(Chatterjee et al., 2023)

modeled by Nkap^GD11807

(Guo et al., 2024)

N^GD14477

model of intestinal cancer

is exacerbated by Pcmt^GD8637

(Banreti et al., 2022)

is exacerbated by Pcmt^RNAi.UAS

(Banreti et al., 2022)

ameliorates cancer

modeled by Src64B^UAS.cCa

(Enomoto et al., 2021)

model of colorectal cancer

is ameliorated by mir-277^UAS.cSa

(Zipper et al., 2022)

ameliorates brain cancer

modeled by Vps35^E42

(Li et al., 2018)

exacerbates cancer

modeled by Mps1^GL00184

(Brás et al., 2021)

modeled by Mps1^HMS01546

(Brás et al., 2021)

modeled by mad2^GLC01381

(Brás et al., 2021)

model of cancer

is exacerbated by Mps1^GL00184

(Brás et al., 2021)

is exacerbated by Mps1^HMS01546

(Brás et al., 2021)

is exacerbated by mad2^GLC01381

(Brás et al., 2021)

N^NICD.UASp

exacerbates carcinoma

modeled by l(2)gl^GD4047

(Chatterjee et al., 2023)

N^{sfGFP,Tag:FLAG}

ameliorates Adams-Oliver syndrome

modeled by Su(H)^T4

(Gagliani et al., 2022)

N^JF02959

ameliorates rhabdoid cancer

modeled by Snr1^HMS00363, BacA\p35^UAS.cHa

(Xie et al., 2017)

N^RNAi.lexAop

ameliorates carcinoma

modeled by Egfr^UAS.cBa, psq^KK111691

(Boukhatmi et al., 2020)

N^UAS.cGa

ameliorates autism spectrum disorder

modeled by Nrx-IV⁴³⁰⁴

(Grice et al., 2015)

N^CA.UAS.cUa

model of central nervous system cancer

is ameliorated by zfh1^UAS.cPa

(Magadi et al., 2020)

is ameliorated by gcm^{UAS.ORF.GW.Tag:HA}

(Magadi et al., 2020)

exacerbates carcinoma

modeled by l(2)gl^GD4047

(Jevitt et al., 2021)

N^RNAi.UAS.cUa

model of intestinal cancer

is ameliorated by Smox^JF02320

(Ayyaz et al., 2015)

N^ΔE.UAS

model of central nervous system cancer

is exacerbated by InR^A1325D.UAS

(Voutyraki et al., 2023)

is ameliorated by InR^K1409A.UAS

(Voutyraki et al., 2023)

is ameliorated by Imp^HMS01168

(Voutyraki et al., 2023)

Src42A

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Src42A^CA.UAS

model of colorectal cancer

CEA

(Cordero et al., 2014)

model of intestinal cancer

CEA

(Kohlmaier et al., 2015)

Modifiers Based on Experimental Evidence ( 7 )

Allele

Disease

Interaction

References

Src42A^CA.UAS

model of colorectal cancer

is ameliorated by Stat92E^GD4492

(Cordero et al., 2014)

is ameliorated by Egfr^KK100051

(Cordero et al., 2014)

is NOT ameliorated by dome^GD2612

(Cordero et al., 2014)

is ameliorated by Egfr^t1

(Cordero et al., 2014)

is ameliorated by Ras85D^KK108029

(Cordero et al., 2014)

is ameliorated by Ras85D^GD12553

(Cordero et al., 2014)

model of intestinal cancer

is ameliorated by Egfr^RNAi.UAS.cUa

(Kohlmaier et al., 2015)

is ameliorated by Stat92E^RNAi.UAS.cUa

(Kohlmaier et al., 2015)

is ameliorated by Egfr^RNAi.UAS.cUa

(Kohlmaier et al., 2015)

is ameliorated by Stat92E^RNAi.UAS.cUa

(Kohlmaier et al., 2015)

Src42A^E1

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

Src42A^KG02515

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

Src42A^k10108

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

Src42A^GD8338

exacerbates amyotrophic lateral sclerosis type 8

modeled by Vap33^{P58S.UAS.Tag:FLAG}

(Sanhueza et al., 2015)

Src42A^HMC04138

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Src42A^HMS02755

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Src64B

Models Based on Experimental Evidence ( 4 )

Allele

Disease

Evidence

References

Src64B^YF.UAS

model of kidney disease

CEA

(Tutor et al., 2014)

Src64B^UAS.cCa

model of cancer

CEA

(Enomoto et al., 2021)

CEA with Ras85D^V12.UAS

(Enomoto et al., 2021)

model of colorectal cancer

CEA

(Cordero et al., 2014)

model of intestinal cancer

CEA

(Nászai et al., 2021)

Src64B^UY1332

model of carcinoma

CEA

(Pagarigan et al., 2013)

Src64B^UAS.cUa

model of intestinal cancer

CEA

(Kohlmaier et al., 2015)

Modifiers Based on Experimental Evidence ( 8 )

Allele

Disease

Interaction

References

Src64B^GL00297

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Src64B^GD12263

ameliorates cancer

modeled by Ras85D^V12.UAS

(Ma et al., 2013)

Src64B^G7151

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Src64B^UAS.cCa

model of cancer

is ameliorated by Delta^DN.UAS

(Enomoto et al., 2021)

is ameliorated by Delta^RevF10

(Enomoto et al., 2021)

is ameliorated by N^ECN.UAS

(Enomoto et al., 2021)

is ameliorated by N^GD14477

(Enomoto et al., 2021)

is ameliorated by shg^UAS.sgGFP

(Enomoto et al., 2021)

is exacerbated by zfh1^UAS.cPa

(Enomoto et al., 2021)

is exacerbated by N^ICN.UAS

(Enomoto et al., 2021)

is ameliorated by Delta^DN.UAS

(Enomoto et al., 2021)

model of colorectal cancer

is ameliorated by Egfr^DN.UAS

(Cordero et al., 2014)

is ameliorated by Ras85D^KK108029

(Cordero et al., 2014)

is ameliorated by Ras85D^GD12553

(Cordero et al., 2014)

is ameliorated by Hsap\MATK^UAS.cVa

(Cordero et al., 2014)

model of intestinal cancer

is ameliorated by Rala^KK108989

(Nászai et al., 2021)

Src64B^JF03234

ameliorates cancer

modeled by Hsap\CDH3^UASp.cPa

(Faria et al., 2023)

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Src64B^UY1332

model of carcinoma

is ameliorated by PRL-1^UAS.cPa

(Pagarigan et al., 2013)

Src64B^HMC03327

ameliorates cancer

modeled by Hsap\CDH3^UASp.cPa

(Faria et al., 2023)

ameliorates lung adenocarcinoma

modeled by Hsap\KIF5B::Hsap\RET^UAS.cDa

(Das and Cagan, 2017)

Src64B^UAS.cUa

model of intestinal cancer

is ameliorated by Egfr^RNAi.UAS.cUa

(Kohlmaier et al., 2015)

is ameliorated by Stat92E^RNAi.UAS.cUa

(Kohlmaier et al., 2015)

is ameliorated by Egfr^RNAi.UAS.cUa

(Kohlmaier et al., 2015)

is ameliorated by Stat92E^RNAi.UAS.cUa

(Kohlmaier et al., 2015)

Alleles Representing Disease-Implicated Variants

Genetic Tools, Stocks and Reagents

Sources of Stocks

Contact lab of origin for a reagent not available from a public stock center.

Bloomington Stock Center Disease Page

Related mammalian, viral, bacterial, or synthetic transgenes

Allele

Transgene

Publicly Available Stocks

Selected Drosophila transgenes

Allele

Transgene

Publicly Available Stocks

N^HD_CFD01184

P{HD_CFD01184}

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01184}attP40/CyO-GFP

y¹ w^*; P{UAS-Delta.ΔE}B2a2

N^ECN.UAS

P{UAS-N.ECN}

P{hsFLP}12, y¹ w^*; P{UAS-N.ECN}2; MKRS/TM2

N^ICN.UAS

P{UAS-N.ICN}

N^{FLN.ΔCdc10.UAS}

P{UAS-N.FLNDeltaCdc10}

N^{UAS.Tag:V5,Tag:polyHis}

P{UAS-N.V5}

N^{sfGFP,Tag:FLAG}

PBac{N-GFP.FLAG}

y¹ w^*; PBac{N-GFP.FLAG}VK00033/TM6C, Sb¹

w^*; P{UAS-Src64B.C}2

Src64B^YF.UAS

P{UAS-Src64B.YF}

y¹ w^*; P{UAS-Src64B.YF}121/CyO

Src42A^CA.UAS

P{UAS-Src42A.CA}

w¹¹¹⁸; P{UAS-Src42A.CA}5

RNAi constructs available

Allele

Transgene

Publicly Available Stocks

N^RNAi.lexAop

P{lexAop-N.RNAi}

N^{RNAi.13xlexAop.cZa}

P{13xlexAop-N.RNAi.Z}

w^*; P{UAS-N.RNAi.P}9G

w¹¹¹⁸; P{GD14477}v27228/TM3

y¹ v¹; P{TRiP.JF02959}attP2

N^JF01637

P{TRiP.JF01637}

y¹ v¹; P{TRiP.JF01637}attP2

N^JF01043

P{TRiP.JF01043}

y¹ v¹; P{TRiP.JF01043}attP2

N^JF01053

P{TRiP.JF01053}

y¹ v¹; P{TRiP.JF01053}attP2

N^JF01356

P{TRiP.JF01356}

y¹ v¹; P{TRiP.JF01356}attP2

N^JF01693

P{TRiP.JF01693}

y¹ v¹; P{TRiP.JF01693}attP2

y¹ v¹; P{TRiP.HMS00001}attP2

N^HMS00009

P{TRiP.HMS00009}

y¹ v¹; P{TRiP.HMS00009}attP2

y¹ sc^* v¹ sev²¹; P{TRiP.GL00092}attP2

N^GLV21004

P{TRiP.GLV21004}

y¹ sc^* v¹ sev²¹; P{TRiP.GLV21004}attP2

w^*; P{UAS-Src64B.RNAi}6.1

Src64B^GD12263

P{GD12263}

w¹¹¹⁸ P{GD12263}v35252

Src64B^JF03234

P{TRiP.JF03234}

y¹ v¹; P{TRiP.JF03234}attP2

Src64B^GL00297

P{TRiP.GL00297}

y¹ sc^* v¹ sev²¹; P{TRiP.GL00297}attP2

y¹ v¹; P{TRiP.HMC03327}attP40

Src64B^HMC05164

P{TRiP.HMC05164}

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05164}attP40

w¹¹¹⁸; P{GD8338}v17643

Src42A^GD10610

P{GD10610}

w¹¹¹⁸; P{GD10610}v26019/CyO

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02755}attP40/CyO

Src42A^HMC04138

P{TRiP.HMC04138}

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04138}attP2/TM3, Sb¹

Selected Drosophila classical alleles

Allele

Allele class

Mutagen

Publicly Available Stocks

N^ETX52

amorphic allele - genetic evidence

Delta2-3 transposase

N^55e11

loss of function allele

spontaneous

N^55e11 P{neoFRT}19A/FM7c

N^fa-g

loss of function allele

spontaneous

w^a N^fa-g; Rho1^E3.10/CyO

N^264-40

amorphic allele - genetic evidence

X ray

w^a N^264-40 rb¹/C(1)DX, y¹ f¹; Dp(1;2)72c21/+

N^FE1

loss of function allele

X ray

N^l1N-ts1

ethyl methanesulfonate

y¹ N^l1N-ts1 g² f¹/C(1)DX, y¹ w¹ f¹

N^S-317

loss of function allele

ethyl methanesulfonate

N^l1N-2

amorphic allele - genetic evidence

gamma ray

N^FX9

loss of function allele

X ray

N^FE2

loss of function allele

X ray

N^FX8

loss of function allele

X ray

N¹

loss of function allele

y¹ w^* N¹/FM7c, P{GAL4-twi.G}108.4, P{UAS-2xEGFP}AX

N^FX4

loss of function allele

X ray

N^eU10

loss of function allele

ethyl methanesulfonate

N^eAS7b

loss of function allele

ethyl methanesulfonate

N^60g11

amorphic allele - genetic evidence

X ray

N^FX2

loss of function allele

X ray

N^XL86

loss of function allele

ethyl methanesulfonate

N²

loss of function allele

N^FX5

loss of function allele

X ray

N^FX7

loss of function allele

X ray

N^Yi66

loss of function allele

ethyl methanesulfonate

N^264-47

loss of function allele

X ray

N^264-39

loss of function allele

X ray

w^ch2 N^264-39/FM4, Bar⁺

N^X81K1

loss of function allele

N^fa-swb

X ray

w^a N^fa-swb

N³

loss of function allele

N^3b22

loss of function allele

ethyl methanesulfonate

N^FX6

loss of function allele

X ray

N^XK11

amorphic allele - genetic evidence

N^nd-1

loss of function allele

spontaneous

N^nd-1 rb¹

N^M1

loss of function allele

ethyl methanesulfonate

N^FX3

loss of function allele

X ray

N^FX1

loss of function allele

X ray

N^X114

loss of function allele

ethyl methanesulfonate

N^66l2

amorphic allele - genetic evidence

N^nd-3

X ray

N^nd-3 rb¹/C(1)DX, y¹ f¹

Src64B^UY1332

P-element activity

y¹ w^67c23; P{Mae-UAS.6.11}Src64B^UY1332

Src64B^ko

amorphic allele - genetic evidence

ends-out gene targeting

w^*; Src42A^E1/CyO; TI{TI}Src64B^ko/TM6B, Tb⁺

Src64B^G7151

P-element activity

y¹ w^*; P{EP}Src64B^G7151 CG32246^G7151

Src42A^k10108

P-element activity

y¹ w^67c23 ; P{lacW}Src42A^k10108 / CyO

Src42A^KG02515

P-element activity

y¹; P{SUPor-P}Src42A^KG02515/CyO; ry⁵⁰⁶

Src42A^E1

ethyl methanesulfonate

w¹¹¹⁸; Src42A^E1/CyO

Src42A^26-1

loss of function allele

w^*; Src42A^26-1/CyO

References (4)

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