FB2025_01 , released February 20, 2025
Gene Group: C2H2 ZINC FINGER TRANSCRIPTION FACTORS
Open Close
General Information
Name
C2H2 ZINC FINGER TRANSCRIPTION FACTORS
Species
D. melanogaster
Symbol
ZF-C2H2
FlyBase ID
FBgg0000732
Date last reviewed
2021-09-30
Number of members
272
Description
Description
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Notes on Group

The C2H2 ZINC FINGER TRANSCRIPTION FACTORS gene group is a collection of genes encoding proteins containing Cys2His2 zinc finger motifs. This domain is most frequently associated with DNA binding, but in some cases this domain has been shown to mediate RNA and/or protein interactions. (PMID:15718139 and PMID:18286240).

Note that within this group, a subclass of C2H2 zinc finger transcription factors are found only in arthropods, its representatives contain a specific domain called ZAD (Zinc finger associated domain) thought to mediate protein-protein interactions (FBrf0220103, FBrf0155739). This corresponds to the InterPro domain Zinc finger, AD-type (IPR012934).

Source Material
The C2H2 ZINC FINGER TRANSCRIPTION FACTORS Gene Group has been compiled using the following publication(s): Baumann et al., 2018, Zolotarev et al., 2016, Shaman et al., 2014, Krystel and Ayyanathan, 2013, Pfreundt et al., 2010, and Chung et al., 2002 .
Key Gene Ontology (GO) terms
Cellular Component
Related Gene Groups
Members (272)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Adult enhancer factor 1
AEF-1
ASCIZ zinc finger protein
dASCIZ
(A+T)-stretch binding protein
brother of odd with entrails limited
bowel, Su(tor)2-1
broad
BR-C, Broad Complex, ecs, npr1, rbp
Bromodomain-containing protein, 140kD
Bub3 interacting GLEBS and Zinc finger domain protein
Dm_2L:87597, lincRNA.S1359
castor
ming, l(3)neo33
cabut
EP2237, dTIEG
combgap
mig, l(2)07659
Chronologically inappropriate morphogenesis
charlatan
l(2)02064
cubitus interruptus
l(4)17, ciD, CID, Gli, ci-D
CKII-α subunit interactor-1
Chromatin-linked adaptor for MSL proteins
Centrosomal protein 190kD
Rb188, DMAP190, Cen190, CP-190, Centrosomal Protein 190
CTCF
dCTCF, CCCTC-binding factor
dendritic arbor reduction 1
debra
BcDNA:LD26519, EP456
disco-related
bae, batone
DNA replication-related element factor
DRE-binding factor, dDREF, DNA replication-related element-binding factor, DNA replication-related element binding factor
deformed wings
Zw5, l(1)zw5, zw-5, zeste-white 5, EG:95B7.6
escargot
l(2)35Ce, l(2)br43, dgl, wizard, shut off
fruitless
sat, satori, BTB-VI
Glucose transporter 4 enhancer factor
stretch, BcDNA:GM06804, BcDNA:GH25505, stretched out
hb transcription factor
hunchback, Rg-pbx
Histone H4 transcription factor
EG:115C2.6
huckebein
gurt, gurtelchen, 5953
Immune-mediated zinc finger protein
jing
1.28, l(2)01094, l(2)22F3, rhumba
ken and barbie
Ken & Barbie, okina, ok
Kruppel-like factor 15
Bteb2, dKlf15
klu transcription factor
klumpfuss, l(3)09036, l(3)10052
Kr transcription factor
Kruppel, If, Dm-Kr
Kr transcription factor homolog 1
Kr-h, Kruppel homolog 1, Pow, l(2)10642, Passion of white
Lobe
Oaz, l(2)03563, O/E-associated zinc finger protein, Dm_2R:42259
Linking immunity and metabolism
lame duck
minc, gfl, myoblasts incompetent, gleeful
longitudinals lacking
eyeful, BTB-IV, misguided, bumper-to-bumper, longitudinal lacking
maternal gene required for meiosis
lincRNA.990
Meiotic central spindle
zinc-finger-motif-protein
Misexpression suppressor of ras 4
EP0386
molting defective
DTS-3, l(3)3DTS
Metastasis associated 1-like
MTA-like, dMTA1-like, MTA1, MTA, dMTA
Metal response element-binding Transcription Factor-1
dMTF-1, metal responsive transcription factor
nervous fingers 1
Nerfin
Neuroectoderm-expressed 2
no ocelli
l(2)35Ba, l(2)br22, nocA, br22, BG:DS04641.1
Optix-binding protein
Obp
ovo
svb, shavenbaby, shaven baby, ovo/svb, ovoD
pebbled
hnt, Hindsight, EP55
pleiohomeotic
l(4)29, YY1, Pleohomeotic, l(4)BU-2, l(4)102EFc
pleiohomeotic like
pho-like
Promyelocytic leukemia zinc finger
PR/SET domain 13
putzig
Z4, Pzg/Z4, p160
rotund
roe, roughened eye, P5.3, tod, tot
Silence-associated factor
Smurfness-associated gene 1
spalt major
sal, spalt, l(2)03602
spalt-related
spalt, sal, sal-r
senseless
Ly, Sensless, sen, sense
sequoia
l(2)vr5, l(2)49Fc, vr5
schnurri
quo, l(2)04738, EP2359
snail
Sco, l(2)br28, l(2)br29, l(2)35Db, br29
sister of odd and bowl
Sp1-like factor for pairing sensitive-silencing
Serendipity δ
sryδ, serendipity delta, sry δ, EH8, sry
suppressor of Hairy wing
suHw
teflon
l(2)k15914
Trithorax-like
GAF, GAGA, GAGA factor, Nc70F, GAGA-factor
tramtrack
Ttk69, Tramtrack69, oversensitive, Ttk88, FTZ-F2
u-shaped
dFOG, FOG
wings down
pqp, sry-h1, pourquoi-pas
weckle
l(2)35Ea, BG:DS09217.5
worniu
l(2)br35, l(2)35Da, br35, BG:DS03023.1
ZAD and Architectural Function 1
zinc finger protein 30C
l(2)k02506, C282
Zn finger homeodomain 1
zfh-1, Zinc-finger homeodomain protein 1, zinc finger homeodomain 1, l(3)00865
Zn finger homeodomain 2
zfh-2, zinc finger homeodomain 2
zelda
vfl, vielfaltig, EP1344
External Data
Synonyms and Secondary IDs
Synonym(s)
ZF-C2H2
C2H2 ZINC FINGER TRANSCRIPTION FACTORS
C2H2 zinc-finger DNA binding proteins
Cys-Cys-His-His motif transcription factors
C2H2 Zinc-finger family transcription factors
Cys2His2 transcription factors
Secondary FlyBase ID(s)
References (7)