FlyBase Gene Report: Dmel\Su(H)

inclusive hindgut primordium

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

(Fisher et al., 2012)

dorsal sensory complex primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

cardiogenic mesoderm

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic neuroblast of ventral nerve cord primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

embryonic lateral cord

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

somatic muscle primordium

(Fisher et al., 2012)

ventral imaginal tissue

Comment: reported as ventral imaginal precursor specific anlage

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

ventral sensory complex anlage

(Fisher et al., 2012)

embryonic stage 11 -- 17

dorsal sensory complex proper primordium

(Schweisguth and Posakony, 1992)

trichogen cell

(Schweisguth and Posakony, 1992)

external sensory organ

(Schweisguth and Posakony, 1992)

embryonic stage 13 -- 16

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

sensory nervous system primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

ventral sensory complex primordium

(Fisher et al., 2012)

embryonic precursor cell of adult muscle

leg disc

(Schweisguth and Posakony, 1992)

eye-antennal disc

(Schweisguth and Posakony, 1992)

wing disc

(Schweisguth and Posakony, 1992)

pupal stage P5(ii) -- pupal stage P6

Comment: reference states 16-24 hr APF

(Schweisguth and Posakony, 1992)

epidermis

Comment: reference states 16-24 hr APF

(Schweisguth and Posakony, 1992)

macrochaeta

Comment: assayed at 17h, 21h, 30h APF

(Miller et al., 2009)

microchaeta

Comment: assayed at 17h, 21h, 30h APF

(Miller et al., 2009)

Comment: assayed at 17h, 21h, 30h APF

(Miller et al., 2009)

pupal stage P6

cortical zone of lymph gland primary lobe

Comment: reference states 24 hr APF

(Schweisguth and Posakony, 1992)

trichogen cell

Comment: reference states 24 hr APF

(Schweisguth and Posakony, 1992)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Furukawa et al., 1991)

embryonic stage -- adult stage

(Furukawa et al., 1992)

adult stage | female

(Furukawa et al., 1991)

adult stage | male

(Furukawa et al., 1991)

Additional Descriptive Data

Su(H) is stronglyly detected in all macrochaete socket cells 17, 21 and 30 hours APF. It is also observed in microchaetes at these stages.

(Miller et al., 2009)

Su(H)@ transcripts are detected throughout development by RNAase protection.

(Furukawa et al., 1992)

Su(H) transcripts are present throughout the syncytial embryo. During cellularization, the rapid disappearance of putative maternal transcripts reveals a transient striped pattern. Transcripts are next observed from stage 11 on in external sensory organs. In the thoracic and abdominal segments the es cells were identified as the tormogen and trichogen. In late third instar larvae, expression is observed in many larval and imaginal tissues but not in the CNS. Transcripts are broadly distributed in the discs but in a nonuniform pattern. In the wing disc, transcripts are most abundant in the posterior region of the wing pouch. In the leg disc, expression is also observed in a posterior zone of the disc. In the eye-antennal disc, low levels of expression are observed posterior to the morphogenetic furrow and and in the central antennal region while higher levels are observed in the vicinity of the furrow and along the margins of the disc. In 16-24hr pupae, Su(H) is expressed in many tissues including developing muscle and epidermis. In michrochaetae and macrochaetae, expression is observed in a couple of large cells that appear to be the tormogen and trichogen. Expression in the tormogen occurs at a higher level.

(Schweisguth and Posakony, 1992)

Su(H) transcripts are detected in RNA from embryos, adult males and adult females.

(Furukawa et al., 1991)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

(Tokusumi et al., 2010)

medullary zone of lymph gland primary lobe

(Tokusumi et al., 2010)

embryonic/larval optic lobe | ubiquitous

(Wang et al., 2011)

larval brain | ubiquitous

(Wang et al., 2011)

larval ventral nerve cord | ubiquitous

(Wang et al., 2011)

wandering third instar larval stage

eye photoreceptor cell

(Tsuda et al., 2002)

adult stage

adult brain | ubiquitous

(Song et al., 2009)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

external sensory organ

(Gho et al., 1996)

presumptive embryonic/larval peripheral nervous system | restricted

(Gho et al., 1996)

external sensory organ precursor cell IIb

(Gho et al., 1996)

(Gho et al., 1996)

(Gho et al., 1996)

(Gho et al., 1996)

external sensory organ precursor cell IIa

(Gho et al., 1996)

tormogen cell of interommatidial bristle

(Gho et al., 1996)

(Gho et al., 1996)

Additional Descriptive Data

Su(H) protein is observed in the nucleus in all cells in the third instar wing disc. It was sometimes observed in the surrounding cytoplasm of both macrochaete and microchaete SOPs. It is observed in the nucleus and cytoplasm of socket cells. It does not co-localize with N protein at the apicolateral membrane in socket cells.

(Wang et al., 2011, Gho et al., 1996)

Su(H) protein is strongly expressed in prohemocytes in the medullary zone of the lymph gland and is weakly expressed in differentiated hemocytes in the cortical zone.

(Tokusumi et al., 2010)

Su(H) protein isdetected by western blots in extracts from embryos, third instar wingdiscs, and nota dissected from 24hr APF pupae. It's expression was studiedduring SOP specification by immunolocalization. In wing discs of latethird instar larvae, it is expressed at a low level in all nuclei. It ispresent equally in macrochaete SOPs and the neighboring proneuralclusters. A similar observation was made fro microchaete SOPs in thedeveloping notum at 14hr APF. In this case, Su(H) protein is detected inboth the microchaete SOPs and the surrounding epithelial cells. FollowingSOP division, no difference in staining is seen between SOPIIa and SOPIIb.With further differentiation of SOPIIa and SOPIIb, Su(H) proteinexpression is observed specifically in the socket cell. This is true insocket cells of the machrochaetes, microchaetes and the interommatidialbristle. Su(H) protein is also expressed in a small number of embryonicsense organ cells per segment. These support cells show a 'socket-like'morphology.

(Gho et al., 1996)

Marker for

wandering third instar larval stage

(Ayeni et al., 2016, Mou et al., 2012)

Subcellular Localization

CV Term

Evidence

References

part_of CSL-Notch-Mastermind transcription factor complex

inferred from direct assay

(Gomez-Lamarca et al., 2018, Contreras et al., 2015, Kitagawa et al., 2001)

inferred from physical interaction with FLYBASE:mam; FB:FBgn0002643,FLYBASE:N; FB:FBgn0004647

(Maier et al., 2011)

located_in cytoplasm

inferred from direct assay

(Gho et al., 1996)

is_active_in nucleus

inferred from direct assay

(Mo et al., 2023)

located_in nucleus

inferred from direct assay

(Gho et al., 1996)

located_in polytene chromosome

inferred from direct assay

(Marygold et al., 2011, Goodfellow et al., 2007)

part_of protein-containing complex

inferred from physical interaction with FLYBASE:N; FB:FBgn0004647

(Kelly et al., 2007)

part_of RNA polymerase II transcription repressor complex

inferred from physical interaction with FLYBASE:H; FB:FBgn0001169

(Smylla et al., 2019, Maier et al., 2011, Barolo et al., 2002)

part_of transcription repressor complex

inferred from genetic interaction with FLYBASE:ebi; FB:FBgn0263933

(Tsuda et al., 2006)

Expression Deduced from Reporters

Reporter: P{ST.lexA::HG}IP-4

Stage

Tissue/Position (including subcellular localization)

Reference

eye disc

(Bloomington Drosophila Stock Center, 2019)

wing disc

(Bloomington Drosophila Stock Center, 2019)

larval central nervous system

(Bloomington Drosophila Stock Center, 2019)

larval ventral nerve cord

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval salivary gland

(Bloomington Drosophila Stock Center, 2019)

Reporter: P{Su(H)-GAL4.ASE5}

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage

enteroblast of posterior adult midgut epithelium

(Barolo et al., 2002)

Reporter: P{Su(H)GBE-GAL4.L}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

enteroblast

(Shi et al., 2023, Lu and Li, 2015)

(Zhao et al., 2022, Shi et al., 2021, Lu and Li, 2015)

Reporter: P{Su(H)GBE-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

larval hindgut imaginal ring | posterior

peripheral cell

(Zeng et al., 2010)

(González-Morales et al., 2015)

adult stage

enteroblast

(Zhai et al., 2015, Buchon et al., 2010, Zeng et al., 2010)

enteroblast of posterior adult midgut epithelium

(Hudry et al., 2016, Xing et al., 2015)

Reporter: P{Su(H)-GFP.ASE}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

View Dmel\Su(H) in JBrowse

(Barolo et al., 2000)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Su(H)

View exonic expression by tissue for Dmel\Su(H)

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004837

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34881/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004837

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004837

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004837

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3497

Flygut - An atlas of the Drosophila adult midgut

FBgn0004837

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Su(H)

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 74 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 71 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Su(H)

Transgenic constructs containing regulatory region of Su(H)

Aberrations (Deficiencies and Duplications) ( 146 )

Inferred from experimentation ( 146 )

Gene disrupted in

Df(2L)64j

(Iyengar et al., 1999, Furukawa et al., 1992, Ashburner et al., 1990, Ashburner, 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)A48

(Ma et al., 2009, Spradling et al., 1999, BDGP Project Members, 1994-1999, Grau et al., 1984, Ashburner et al., 1982)

Df(2L)A72

(Ashburner et al., 1990, Ashburner et al., 1982)

Df(2L)A215

(Ashburner et al., 1982)

Df(2L)A220

(Roote, 1996.5.20, Ashburner et al., 1982)

Df(2L)A246

(Ashburner et al., 1982)

Df(2L)A263

(Furukawa et al., 1992, Ashburner et al., 1982)

Df(2L)A264

(Ashburner et al., 1982)

Df(2L)A267

(Ashburner et al., 1990, Ashburner et al., 1982)

Df(2L)A376

(Ashburner, 1982, Ashburner et al., 1982)

Df(2L)A377

(Ashburner, 1982, Ashburner et al., 1982)

Df(2L)A400

(Ashburner, 1982, Ashburner et al., 1982)

Df(2L)Antp^Ctxrv1

(Roote, 1996.8)

Df(2L)ARR1

(Roote, 1996.8, Furukawa et al., 1992, Ashburner et al., 1990, Gubb et al., 1984, Ashburner, 1982)

Df(2L)b80e4

(Ashburner et al., 1990)

Df(2L)b84h50

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Furukawa et al., 1992)

Df(2L)b87e25

(Alexandrova et al., 1996)

Df(2L)BSC299

(Christensen and Cook, 2007.5.8)

Df(2L)do1

(Ashburner, 1982)

Df(2L)el20

(Ashburner et al., 1990)

Df(2L)el28

(Furukawa et al., 1992, Ashburner et al., 1990)

Df(2L)el77

(Woodruff and Ashburner, 1979)

Df(2L)Exel7061

(Ryder, 2004.4.26)

Df(2L)fn1

(Grau et al., 1984, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn3

(Woodruff and Ashburner, 1979)

Df(2L)fn5

(Furukawa et al., 1992, Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn7

(Woodruff and Ashburner, 1979)

Df(2L)fn12

(Ashburner et al., 1990, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn15

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn26

(Ashburner et al., 1990, Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn27

(Ashburner et al., 1990, Ashburner, 1982, Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn30

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)n78l3

(Ashburner et al., 1990)

Df(2L)noc11

(Ashburner et al., 1990)

Df(2L)osp29

(Furukawa et al., 1992, Grau et al., 1984)

Df(2L)osp38

(Ashburner et al., 1990)

Df(2L)Sco7

(Ashburner et al., 1990)

Df(2L)Sco^rv4

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

Df(2L)Sco^rv23

(Grau et al., 1984, Ashburner, 1982)

Df(2L)TE35B-1

(Gubb et al., 1985)

Df(2L)TE35B-2

(Gubb et al., 1985)

Df(2L)TE35B-5

(Gubb et al., 1985)

Df(2L)TE35B-6

(Gubb et al., 1985)

Df(2L)TE35BC-1

(Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1981)

Df(2L)TE35BC-4

(Fortini and Artavanis-Tsakonas, 1994, Ashburner et al., 1990, Gubb et al., 1984, Ashburner, 1982)

Df(2L)TE35BC-6

(Gubb et al., 1984)

Df(2L)TE35BC-7

(Furukawa et al., 1992, Gubb et al., 1984)

Df(2L)TE35BC-8

(Gubb et al., 1984)

Df(2L)TE35BC-23

(Gubb et al., 1984)

Df(2L)TE35BC-24

(Ma et al., 2009, Iyengar et al., 1999, Gho et al., 1996, Gubb et al., 1984)

Df(2L)TE35BC-28

(Fortini and Artavanis-Tsakonas, 1994, Furukawa et al., 1992, Gubb et al., 1984)

Df(2L)TE35BC-29

(Gubb et al., 1984)

Df(2L)TE35BC-31

(Gubb et al., 1984)

Df(2L)TE35BC-34

(Ashburner et al., 1990, Gubb et al., 1984)

Df(2L)TE35BC-35

(Gubb et al., 1984)

Df(2L)TE35D-20

(Ashburner et al., 1990)

Df(2L)TE35D-23

(Ashburner et al., 1990)

Df(2L)W

(Woodruff and Ashburner, 1979)

In(2L)75c^LC158.1^R

(Woodruff and Ashburner, 1979)

In(2L)75c

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Grau et al., 1984, Ashburner, 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

In(2L)C158^LSco^rv11R

(Ashburner and Harrington, 1984)

In(2L)C158^LSco^rv17R

(Ashburner and Harrington, 1984)

In(2L)el18

(Ashburner et al., 1990)

In(2L)TE35B-13

(Gubb et al., 1985)

In(2LR)noc^4LSco^rv9R

(Ashburner and Harrington, 1984)

In(2LR)TE35B-6^LSco^rv9R

(Ashburner and Harrington, 1984)

T(Y;2)A80^DR15^P

(Woodruff and Ashburner, 1979)

Tp(2;2)A446

(Ashburner et al., 1982)

Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Sco^rv13

(Ashburner and Harrington, 1984)

Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Sco^rv13

(Ashburner and Harrington, 1984)

Ts(Y;2Lt)el⁴+Ts(YSt;2Rt)R15

(Roote, 1996.1.11, Roote, 1996.8)

Gene not disrupted in

Df(2L)A47

(Ashburner et al., 1982)

Df(2L)A63

(Ashburner et al., 1982)

Df(2L)A178

(Ashburner et al., 1982)

Df(2L)A217

(Ashburner et al., 1982)

Df(2L)A245

(Ashburner et al., 1982)

Df(2L)A260

(Ashburner et al., 1982)

Df(2L)A266

(Ashburner et al., 1982)

Df(2L)A379

(Ashburner et al., 1982)

Df(2L)A445

(Ashburner et al., 1982)

Df(2L)b75

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

Df(2L)b80k

(Roote, 1996.8)

Df(2L)b84a3

(Furukawa et al., 1992)

Df(2L)b84a7

(Furukawa et al., 1992)

Df(2L)el77

(Woodruff and Ashburner, 1979)

Df(2L)fn2

(Grau et al., 1984, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn3

(Ashburner, 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn7

(Ashburner, 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn31

(Ashburner, 1982, Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn36

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)H20

(Ashburner et al., 1990)

(Roote, 2000.6.13)

(Roote, 2000.6.13)

(Roote, 2000.6.13)

(Roote, 2000.6.13)

(Roote, 2000.6.13)

(Ashburner et al., 1990)

Df(2L)RA5

(Ashburner et al., 1990)

Df(2L)rd9

(Furukawa et al., 1992, Ashburner et al., 1990)

Df(2L)RM5

(Ashburner et al., 1990)

Df(2L)RN2

(Ashburner et al., 1990)

Df(2L)Sco-1

(Ashburner, 1982)

Df(2L)Sco^rv10

(Grau et al., 1984)

Df(2L)Sco^rv16

(Ashburner et al., 1990, Grau et al., 1984)

Df(2L)Sco^rv18

(Ashburner et al., 1990)

Df(2L)Sco^rv19

(Ashburner et al., 1990, Grau et al., 1984)

Df(2L)Sco^rv25

(Ashburner et al., 1990, Grau et al., 1984)

Df(2L)SS1

(Ashburner et al., 1990, Grau et al., 1984)

Df(2L)TE35B-3

(Gubb et al., 1985)

Df(2L)TE35B-4

(Gubb et al., 1985)

Df(2L)TE35B-7

(Gubb et al., 1985)

Df(2L)TE35B-8

(Gubb et al., 1985)

Df(2L)TE35B-9

(Gubb et al., 1985)

Df(2L)TE35B-10

(Gubb et al., 1985)

Df(2L)TE35B-11

(Gubb et al., 1985)

Df(2L)TE35B-12

(Gubb et al., 1985)

Df(2L)TE35B-15

(Gubb et al., 1985)

Df(2L)TE35BC-3

(Ashburner et al., 1990, Grau et al., 1984, Gubb et al., 1984, Ashburner, 1982)

Df(2L)TE35D-1

(Ashburner et al., 1990)

Df(2L)TE35D-2

(Furukawa et al., 1992, Ashburner et al., 1990)

Df(2L)TE35D-3

(Ashburner et al., 1990)

Df(2L)TE35D-4

(Ashburner et al., 1990)

Df(2L)TE35D-6

(Furukawa et al., 1992, Ashburner et al., 1990)

Df(2L)TE35D-13

(Furukawa et al., 1992, Ashburner et al., 1990)

Df(2L)TE35D-14

(Ashburner et al., 1990)

Df(2L)TE35D-15

(Furukawa et al., 1992, Ashburner et al., 1990)

Df(2L)TE35D-16

(Ashburner et al., 1990)

Df(2L)TE35D-18

(Furukawa et al., 1992)

Df(2L)TE35D-19

(Ashburner et al., 1990)

Df(2L)TE35D-21

(Ashburner et al., 1990)

Df(2L)TE35D-22

(Ashburner et al., 1990)

Df(2L)W

(Woodruff and Ashburner, 1979)

In(2L)75c^LC158.1^R

(Woodruff and Ashburner, 1979)

In(2L)dpp^s22Ldpp^d36R

(Ashburner et al., 1990)

In(2LR)Sco^rv1-DV7

(Ashburner et al., 1990)

T(2;3)Sco^rv7

(Ashburner et al., 1990, Grau et al., 1984, Woodruff and Ashburner, 1979)

T(Y;2)J165^DP58^P

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

T(Y;2)R15^DJ165^P

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

Gene not duplicated in

Dp(2;2)Adh3

(Ashburner, 1982, Ashburner et al., 1982)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Scer\GAL4^Bx-MS1096

Su(H)^{UAS.ORF.GW.Tag:HA}

lethal (with Su(H)¹)

Su(H)^EG37

lethal (with Su(H)^EG37)

Su(H)¹

lethal | neurogenic phenotype | rescuable maternal effect

lethal | recessive

lethal - all die before end of larval stage

Su(H)^attP

lethal - all die before end of larval stage | recessive

Su(H)⁸

lethal - all die before end of pupal stage

lethal - all die before end of pupal stage | recessive

lethal - all die during pharate adult stage, with Scer\GAL4^sd.PU

Su(H)^UAS.cMa

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Su(H)^GD1544

viable

Su(H)^EY07695

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Su(H)^GD1544

Sterility

Allele

fertile

Su(H)^EY07695

Other Phenotypes

Allele

abnormal cell shape | somatic clone | third instar larval stage

Su(H)^del47

abnormal developmental rate

Su(H)^S269D

abnormal memory | adult stage

Su(H)^hs.PS

abnormal memory | adult stage | dominant

abnormal mitotic cell cycle

Su(H)⁸

abnormal mitotic cell cycle | cell autonomous | somatic clone

Su(H)^del47

abnormal neuroanatomy | adult stage, with Scer\GAL4^ato.3.6

abnormal neuroanatomy | embryonic stage 13, with Scer\GAL4^sim.P3.7

Su(H)^{VP16.UAS.Tag:MYC}

abnormal neuroanatomy | embryonic stage 16, with Scer\GAL4^sim.P3.7

Su(H)^{VP16.UAS.Tag:MYC}

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^elav.PU

Su(H)^{RNAi.2056.UAS}

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^elav-C155

Su(H)^{RNAi.2056.UAS}

abnormal neuroanatomy | somatic clone

Su(H)^del47

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^insc-Mz1407

Su(H)^VP16.UAS

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^pnt-14-94

Su(H)^VP16.UAS

abnormal planar polarity

Su(H)^EnR.hs.2sev

abnormal planar polarity | somatic clone

Su(H)^EnR.hs.2sev

abnormal size, with Scer\GAL4^bi-omb-Gal4

abnormal size | pharate adult stage, with Scer\GAL4^sd.PU

Su(H)^UAS.cMa

abnormal size | somatic clone

Su(H)^del47

abnormal size | third instar larval stage

Su(H)^attP

decreased cell number | embryonic stage

decreased cell number | larval stage

decreased cell number | somatic clone

Su(H)^del47

decreased cell number | third instar larval stage, with Scer\GAL4^lz-gal4

Su(H)^HM05110

decreased cell size | third instar larval stage, with Scer\GAL4^lz-gal4

Su(H)^HM05110

decreased occurrence of cell division | larval stage | somatic clone

Su(H)^del47

decreased size | adult stage, with Scer\GAL4^vg.QE

Su(H)^UAS.cMa

hyperplasia, with Scer\GAL4^ptc-559.1

Su(H)^{UAS.GFP,Tag:V5}

hyperplasia | adult stage, with Scer\GAL4^Eq

Su(H)^UAS.cNa

hyperplasia | adult stage, with Scer\GAL4^GMR.PF

hyperplasia | embryonic stage

hyperplasia | third instar larval stage

hyperplasia | third instar larval stage, with Scer\GAL4^bi-omb-Gal4

increased cell death | somatic clone | third instar larval stage

Su(H)^del47

increased cell number, with Scer\GAL4^bi-omb-Gal4

increased cell number | adult stage, with Scer\GAL4^esg.PU

Su(H)^HM05110

increased cell number | embryonic stage

Su(H)^S269A

increased cell number | embryonic stage, with Scer\GAL4^elav.PU

Su(H)^{RNAi.2056.UAS}

increased cell number | larval stage

Su(H)^S269A

increased cell number | somatic clone

Su(H)^del47

increased cell number | third instar larval stage, with Scer\GAL4^Antp-21

Su(H)^KK101550

increased cell number | third instar larval stage, with Scer\GAL4^insc-Mz1407

Su(H)^VP16.UAS

increased cell number | third instar larval stage, with Scer\GAL4^lz-gal4

Su(H)^{VP16.UAS.Tag:MYC}

increased cell number | third instar larval stage, with Scer\GAL4^pnt-14-94

Su(H)^VP16.UAS

increased cell size | third instar larval stage, with Scer\GAL4^lz-gal4

Su(H)^{VP16.UAS.Tag:MYC}

increased occurrence of cell division | adult stage, with Scer\GAL4^esg.PU

Su(H)^HM05110

increased occurrence of cell division | adult stage | female limited | somatic clone

Su(H)^del47

increased occurrence of cell division | larval stage

Su(H)^VP16.UAS

increased occurrence of cell division | larval stage, with Scer\GAL4^ap-md544

Su(H)^UAS.cNa

increased occurrence of cell division | larval stage, with Scer\GAL4^wor.PA

Su(H)^HMS05748

neoplasia | adult stage, with Scer\GAL4^GMR.PU

Su(H)^UAS.cNa

neoplasia | adult stage, with Scer\GAL4^ptc-559.1

Su(H)^UAS.cNa

some die during larval stage | recessive

Su(H)⁸

some die during pupal stage, with Scer\GAL4^pnr-MD237

Su(H)^GD1544

some die during pupal stage | recessive

visible

visible, with Scer\GAL4^bi-md653

Su(H)^UAS.cNa

visible, with Scer\GAL4^Eq

Su(H)^UAS.Tag:MYC

visible, with Scer\GAL4^pnr-MD237

Su(H)^RNAi.UAS.cRa

visible | adult stage, with Scer\GAL4^bi-omb-Gal4

visible | adult stage, with Scer\GAL4^GMR.PF

visible | adult stage, with Scer\GAL4^GMR.PU

Su(H)^UAS.cNa

visible | adult stage, with Scer\GAL4^sca.PU

Su(H)^UAS.cMa

visible | adult stage, with Scer\GAL4^vg.QE

Su(H)^UAS.cMa

visible | pharate adult stage, with Scer\GAL4^sd.PU

Su(H)^UAS.cMa

visible | recessive

visible | recessive | somatic clone

wild-type

Phenotype manifest in

Allele

adult ALl1 lineage neuron | somatic clone

Su(H)^del47

adult antennal mechanosensory and motor center projection neuron | somatic clone

Su(H)^del47

adult external thorax, with Scer\GAL4^Bx-MS1096

adult midgut

Su(H)^del47

adult midgut, with Scer\GAL4^esg.PU

Su(H)^HM05110

adult midgut epithelium | somatic clone

Su(H)^del47

adult posterior midgut epithelium | female limited | somatic clone

Su(H)^del47

adult thorax, with Scer\GAL4^pnr-MD237

Su(H)^RNAi.UAS.cRa

adult uniglomerular antennal lobe projection neuron lPN | somatic clone | increased number

Su(H)^del47

anterior crossvein, with Scer\GAL4^ptc-559.1

Su(H)^UAS.cKa

apterous-expressing neuron of the lateral cluster of the thorax, with Scer\GAL4^elav-C155

Su(H)^{RNAi.2056.UAS}

apterous-expressing neuron of the lateral cluster of the thorax | embryonic stage | increased number, with Scer\GAL4^elav.PU

Su(H)^{RNAi.2056.UAS}

central nervous system | germline clone

chaeta, with Scer\GAL4^Eq

Su(H)^UAS.Tag:MYC

chaeta, with Scer\GAL4^pnr-MD237

Su(H)^RNAi.UAS.cRa

chaeta | absent, with Scer\GAL4^sca.PU

Su(H)^UAS.cMa

dMP2 neuron | ectopic | germline clone

Su(H)⁸

dorsal mesothoracic disc & neuron

Su(H)^del47

dorsal row of double row of wing sensilla

Su(H)²

egg chamber | somatic clone

Su(H)^del47

embryonic/first instar larval cuticle & embryonic head | germ-line clone

embryonic/first instar larval cuticle | germline clone | ventral

embryonic/larval crystal cell | decreased number | embryonic stage

embryonic/larval crystal cell | decreased number | larval stage

embryonic/larval crystal cell | embryonic stage | increased number

Su(H)^S269A

embryonic/larval crystal cell | increased number | larval stage

Su(H)^S269A

embryonic/larval crystal cell | larval stage (with Su(H)⁶)

Su(H)⁸

embryonic/larval crystal cell | larval stage (with Su(H)⁸)

Su(H)⁶

embryonic/larval crystal cell | third instar larval stage, with Scer\GAL4^lz-gal4

embryonic/larval lymph gland (with Su(H)¹)

Su(H)^IB115

embryonic/larval lymph gland (with Su(H)^IB115)

Su(H)¹

embryonic/larval lymph gland | larval stage (with Su(H)⁶)

Su(H)⁸

embryonic/larval lymph gland | larval stage (with Su(H)⁸)

Su(H)⁶

embryonic/larval plasmatocyte (with Su(H)¹)

Su(H)^IB115

embryonic/larval plasmatocyte (with Su(H)^IB115)

Su(H)¹

embryonic epidermis

Su(H)⁸

embryonic hindgut, with Scer\GAL4^455.2

Su(H)^VP16.UAS

embryonic hindgut, with Scer\GAL4^byn-Gal4

Su(H)^VP16.UAS

embryonic large intestine, with Scer\GAL4^byn-Gal4

Su(H)^VP16.UAS

embryonic proventriculus

Su(H)²

eye

eye, with Scer\GAL4^da.PU, Su(H)⁸/Su(H)²

Su(H)^{UAS.GFP,Tag:V5}

eye, with Scer\GAL4^GMR.PF

eye, with Scer\GAL4^GMR.PU

Su(H)^UAS.cNa

eye (with Su(H)²), with Scer\GAL4^da.PU, Su(H)^{UAS.GFP,Tag:V5}

Su(H)⁸

eye (with Su(H)⁸), with Scer\GAL4^da.PU, Su(H)^{UAS.GFP,Tag:V5}

Su(H)²

eye | somatic clone

Su(H)^unspecified

eye-antennal disc

eye disc, with Scer\GAL4^GMR.PF

Su(H)^VP16.UAS

eye disc & neuron | somatic clone | cell autonomous

Su(H)⁸

eye disc | cell autonomous | somatic clone

Su(H)^del47

eye disc | somatic clone

Su(H)^del47

eye photoreceptor cell | increased number

Su(H)^EnR.hs.2sev

eye photoreceptor cell | somatic clone | increased number

Su(H)^EnR.hs.2sev

femur | distal | somatic clone

Su(H)²

follicle cell | somatic clone

follicle stem cell | somatic clone, with Scer\GAL4^Act.PU, Scer\GAL4^Tub.PU, Scer\GAL4^e22c

Su(H)^VP16.UAS.cSa

follicle stem cell | somatic clone, with Scer\GAL4^Tub.PU

Su(H)^VP16.UAS.cSa

germarium region 1 | somatic clone

Su(H)^del47

germinal vesicle | somatic clone

Su(H)^del47

haltere

imaginal disc

Su(H)^k07904

intermediate neuronal progenitor | larval stage, with Scer\GAL4^pnt-14-94

Su(H)^HMS05748

intestinal stem cell | somatic clone | increased number

Su(H)^del47

keyhole structure

Su(H)²

lamellocyte | increased number | third instar larval stage, with Scer\GAL4^Antp-21

Su(H)^KK101550

larval brain | larval stage, with Scer\GAL4^pnt-14-94

Su(H)^HMS05748

larval brain | third instar larval stage, with Scer\GAL4^insc-Mz1407

Su(H)^VP16.UAS

larval brain | third instar larval stage, with Scer\GAL4^pnt-14-94

Su(H)^VP16.UAS

larval central brain, with Scer\GAL4^wor.PA

Su(H)^HMS05748

larval nervous system | embryonic stage

larval neuroblast, with Scer\GAL4^wor.PA

Su(H)^HMS05748

larval outer optic anlage | somatic clone

Su(H)^del47

larval RP2 motor neuron | ectopic | germline clone

Su(H)⁸

larval somatic muscle cell

Su(H)⁸

larval somatic muscle cell | germline clone

Su(H)⁸

leg anterior compartment

Su(H)²

leg joint | somatic clone

Su(H)²

lens

Su(H)^EnR.hs.2sev

lobula columnar neuron LC14, with Scer\GAL4^ato.3.6

Su(H)^KK101550

macrochaeta

macrochaeta, with Scer\GAL4^Bx-MS1096

Su(H)^UAS.cMa

macrochaeta & adult abdomen

Su(H)^hs.1.Tag:MYC

macrochaeta & leg

Su(H)^hs.1.Tag:MYC

macrochaeta | somatic clone

mechanosensory chaeta, with Scer\GAL4^Bx-MS1096

medulla, with Scer\GAL4^ato.3.6

mesonotum, with Scer\GAL4^Eq

Su(H)^UAS.cNa

mesonotum | medial, with Scer\GAL4^pnr-MD237

Su(H)^UAS.cKa

mesothoracic tergum & sensory organ cell & pupa | somatic clone

microchaeta

microchaeta, with Scer\GAL4^Bx-MS1096

Su(H)^UAS.cMa

microchaeta | somatic clone

Su(H)⁸

midline glial cell | embryonic stage 13 | increased number, with Scer\GAL4^sim.P3.7

Su(H)^{VP16.UAS.Tag:MYC}

midline glial cell | embryonic stage 16 | increased number, with Scer\GAL4^sim.P3.7

Su(H)^{VP16.UAS.Tag:MYC}

mitochondrion | larval stage, with Scer\GAL4^pnt-14-94

Su(H)^HMS05748

muscle cell of A1-7 dorsal acute muscle 1, with Scer\GAL4^eve.eme

Su(H)^VP16.UAS

muscle cell of mesothoracic dorsal acute muscle 1, with Scer\GAL4^eve.eme

Su(H)^VP16.UAS

muscle cell of metathoracic dorsal acute muscle 1, with Scer\GAL4^eve.eme

Su(H)^VP16.UAS

neuroblast | germline clone

neuroblast | third instar larval stage, with Scer\GAL4^insc-Mz1407

Su(H)^VP16.UAS

neuroblast | third instar larval stage, with Scer\GAL4^pnt-14-94

Su(H)^VP16.UAS

neuron & eye | somatic clone

Su(H)^del47

neuron & eye | supernumerary | somatic clone

Su(H)^del47

neuron | ectopic

Su(H)⁸

ommatidium

ommatidium | somatic clone

Su(H)^EnR.hs.2sev

pericardial cell, with Scer\GAL4^eve.eme

Su(H)^VP16.UAS

pericardial cell | ectopic, with Scer\GAL4^eve.eme

Su(H)^VP16.UAS

peripheral nervous system | germline clone

photoreceptor cell & axon & larva

Su(H)^E86

photoreceptor cell R7

Su(H)^EnR.hs.2sev

photoreceptor cell R7 | somatic clone

Su(H)^EnR.hs.2sev

photoreceptor cell R8 & eye disc | ectopic | somatic clone

Su(H)^del47

photoreceptor cell R8 & eye disc | somatic clone

Su(H)^del47

photoreceptor cell R8 | cell autonomous | ectopic | somatic clone

Su(H)⁸

photoreceptor neuron

Su(H)^P183

primary lobe of embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4^Antp-21

Su(H)^KK101550

proneural cluster

proneural cluster, with Scer\GAL4^klu-G410

Su(H)^UAS.cKa

proneural cluster & dorsal mesothoracic disc

proventriculus inner layer primordium

Su(H)²

proventriculus intermediate layer primordium

Su(H)²

proventriculus outer layer primordium

Su(H)²

rhabdomere

Su(H)^EnR.hs.2sev

RP2sib neuron | germline clone

Su(H)⁸

sensory mother cell

sensory mother cell | ectopic

Su(H)²

sensory mother cell | third instar larval stage

Su(H)^LLL

sensory organ cell | P-stage | somatic clone

tibia | proximal | somatic clone

Su(H)²

type II neuroblast | somatic clone

tormogen cell | ectopic

tormogen cell | increased number, with Scer\GAL4^sca.PU

Su(H)^UAS.cMa

tormogen cell | somatic clone

Su(H)⁸

trichogen cell

Su(H)^hs.PS.8

type II neuroblast | larval stage, with Scer\GAL4^pnt-14-94

Su(H)^HMS05748

Su(H)^del47

U neuron | ectopic | germline clone

Su(H)⁸

unguis

Su(H)⁷

Usib neuron | germline clone

Su(H)⁸

ventral row of double row of wing sensilla

Su(H)²

visceral trunk mesoderm, with Scer\GAL4^how-24B

Su(H)^{VP16.UAS.Tag:MYC}

vMP2 neuron | ectopic | germline clone

Su(H)⁸

wing

wing, with Scer\GAL4^bi-md653

Su(H)^UAS.cNa

wing, with Scer\GAL4^bi-omb-Gal4

wing, with Scer\GAL4^da.PU, Su(H)⁸/Su(H)²

Su(H)^{UAS.GFP,Tag:V5}

wing, with Scer\GAL4^dpp.blk1

wing, with Scer\GAL4^ptc-559.1

wing (with Su(H)²)

Su(H)⁸

wing (with Su(H)²), with Scer\GAL4^da.PU, Su(H)^{UAS.GFP,Tag:V5}

Su(H)⁸

wing (with Su(H)⁸)

Su(H)²

wing (with Su(H)⁸), with Scer\GAL4^da.PU, Su(H)^{UAS.GFP,Tag:V5}

Su(H)²

wing | pharate adult stage, with Scer\GAL4^sd.PU

Su(H)^UAS.cMa

wing | proximal, with Scer\GAL4^dpp.blk1

Su(H)^{UAS.Tag:NLS(SV40-largeT)}

wing | proximal, with Scer\GAL4^ptc-559.1

Su(H)^UAS.cKa

wing disc

wing disc, with Scer\GAL4^ap-md544

Su(H)^UAS.cNa

wing disc, with Scer\GAL4^bi-omb-Gal4

wing disc, with Scer\GAL4^Bx-MS1096

Su(H)^UAS.cNa

wing disc, with Scer\GAL4^ptc-559.1

wing disc | somatic clone

Su(H)^del47

wing disc | third instar larval stage

wing disc | third instar larval stage, with Scer\GAL4^bi-omb-Gal4

wing margin, with Scer\GAL4^bi-md653

Su(H)^WRPW.UAS

wing margin, with Scer\GAL4^dpp.blk1

Su(H)^{VP16.UAS.Tag:MYC}

wing margin | distal, with Scer\GAL4^ptc-559.1

wing margin | ectopic, with Scer\GAL4^dpp.blk1

Su(H)^VP16.UAS

wing margin | ectopic, with Scer\GAL4^ptc-559.1

Su(H)^VP16.UAS

wing margin bristle, with Scer\GAL4^klu-G410

Su(H)^UAS.cKa

wing vein

wing vein, with Scer\GAL4^bi-md653

Su(H)^UAS.cNa

wing vein, with Scer\GAL4^en-e16E

Su(H)^UAS.cNa

wing vein, with Scer\GAL4^vg.QE

Su(H)^UAS.cMa

wing vein L3

Su(H)²

wing vein L3, with Scer\GAL4^dpp.blk1

wing vein L3, with Scer\GAL4^ptc-559.1

Su(H)^ΔH.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\RBPJ

14 of 14

Yes

Hsap\RBPJL

7 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

Rnor\Rbpj

14 of 14

Yes

Rnor\Rbpjl2

11 of 14

Yes

Rnor\Rbpjl

7 of 14

Yes

Mus musculus (laboratory mouse) (2)

Mmus\Rbpj

14 of 14

Yes

Mmus\Rbpjl

6 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\rbpj

7 of 13

Yes

Xtro\hip1r

1 of 13

Danio rerio (Zebrafish) (3)

Drer\rbpjb

14 of 14

Yes

Drer\rbpja

13 of 14

Yes

Drer\rbpjl

7 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\lag-1

12 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP008935

12 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\cbf11

8 of 12

Yes

Spom\cbf12

5 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Su(H). Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Adams-Oliver syndrome 3

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Su(H)^T4

model of Adams-Oliver syndrome

CEA

(Gagliani et al., 2022)

Su(H)^KK101550

model of alcohol use disorder

CEA

(Petruccelli et al., 2018)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

RBPJ; recombination signal binding protein for immunoglobulin kappa J region

model of Adams-Oliver syndrome 3

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 9 )

Allele

Disease

Interaction

References

Su(H)¹

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

Su(H)²

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

Su(H)^EY07695

ameliorates severe acute respiratory syndrome

modeled by HCoV-SARS\3a^{UAS.CUHK-W1.EGFP}

(Wong et al., 2005)

Su(H)^IB115

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

Su(H)^UAS.Tag:MYC

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\TBP^80Q.UAS

(Ren et al., 2011)

Su(H)^T4

model of Adams-Oliver syndrome

is ameliorated by N^{sfGFP,Tag:FLAG}

(Gagliani et al., 2022)

is ameliorated by Su(H)^{sfGFP,Tag:FLAG}

(Gagliani et al., 2022)

Su(H)^{sfGFP,Tag:FLAG}

ameliorates Adams-Oliver syndrome

modeled by Su(H)^T4

(Gagliani et al., 2022)

Su(H)^HMS05748

exacerbates cancer

modeled by Rbf^HMS03004

(Parkhitko et al., 2021)

Su(H)^RNAi.UAS.cUa

exacerbates autosomal dominant cerebellar ataxia

modeled by Hsap\TBP^80Q.UAS

(Ren et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RBPJ; recombination signal binding protein for immunoglobulin kappa J region

14 of 14

147183

ADAMS-OLIVER SYNDROME 3; AOS3

Adams-Oliver syndrome 3

RBPJL; recombination signal binding protein for immunoglobulin kappa J region like

7 of 14

616104

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

electrophoretic mobility shift assay, fluorescent dye label

(Kuang et al., 2021)

Su(H) - Abd-B

bimolecular fluorescence complementation, fluorescence microscopy

(Baëza et al., 2015)

Su(H) - Amun

experimental knowledge based

(Guruharsha et al., 2011)

Su(H) - Antp

bimolecular fluorescence complementation, fluorescence microscopy

(Baëza et al., 2015)

Su(H) - CG14710

(Shokri et al., 2019)

Su(H) - CG15356

(Moshkin et al., 2009)

Su(H) - CG31441

(Shokri et al., 2019)

Su(H) - CG31955

(Shokri et al., 2019)

Su(H) - CG3815

anti bait coimmunoprecipitation, western blot, anti tag western blot

(Moshkin et al., 2009)

Su(H) - Caf1-105

(Yu et al., 2013)

Su(H) - E2f2

proximity ligation assay, fluorescence microscopy, anti tag coimmunoprecipitation, western blot

(Shokri et al., 2019)

Su(H) - Eip75B

(Wang et al., 2024)

Su(H) - H

isothermal titration calorimetry, predetermined participant, electrophoretic mobility shift assay, fluorescent dye label, two hybrid, pull down, autoradiography, anti tag coimmunoprecipitation, western blot, electrophoretic mobility supershift assay, peptide massfingerprinting, experimental knowledge based, x-ray crystallography, anti tag western blot

Su(H) - HDAC1

anti tag coimmunoprecipitation, western blot, two hybrid, anti tag western blot

(Moshkin et al., 2009)

Su(H) - HP1c

(Sun et al., 2021)

Su(H) - Hr3

(Shokri et al., 2019)

Su(H) - Hr78

(Shokri et al., 2019)

Su(H) - Hsap\TBP

anti bait coimmunoprecipitation, western blot, pull down, autoradiography

(Ren et al., 2011)

Su(H) - Kdm5

(Liefke et al., 2010, Moshkin et al., 2009)

Su(H) - MED19

pull down, anti tag western blot

(Jullien et al., 2022)

Su(H) - N

protein three hybrid, isothermal titration calorimetry, predetermined participant, two hybrid, pull down, autoradiography, anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, cosedimentation, molecular sieving, molecular weight estimation by staining, anti tag western blot, electrophoretic mobility shift assay, electrophoretic mobility supershift assay, coimmunoprecipitation, electron microscopy, three hybrid

Su(H) - Nap1

(Moshkin et al., 2009)

Su(H) - OdsH

anti tag coimmunoprecipitation, anti tag western blot, enzymatic study, luminiscence technology

(Shokri et al., 2019)

Su(H) - Pkc53E

(Deichsel et al., 2024)

Su(H) - Rbfox1

(Shukla et al., 2017)

Su(H) - Rel

bimolecular fluorescence complementation, fluorescence microscopy

(Shokri et al., 2019)

Su(H) - Scr

(Baëza et al., 2015)

Su(H) - Sin3A

anti tag coimmunoprecipitation, anti tag western blot

(Moshkin et al., 2009)

Su(H) - Sirt1

(Horvath et al., 2016)

Su(H) - Smr

two hybrid

(Heck et al., 2012)

Su(H) - Su(Tpl)

anti tag coimmunoprecipitation, anti tag western blot

(Liu et al., 2017)

Su(H) - Taf9

anti tag coimmunoprecipitation, anti tag western blot

(Xie et al., 2014)

Su(H) - Ubx

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018, Baëza et al., 2015)

Su(H) - YL-1

bimolecular fluorescence complementation, fluorescence microscopy

(Shokri et al., 2019)

Su(H) - abd-A

(Bischof et al., 2018, Baëza et al., 2015)

Su(H) - asf1

pull down, autoradiography

(Moshkin et al., 2009, Goodfellow et al., 2007)

Su(H) - da

two hybrid

(Cave et al., 2005)

Su(H) - dom

(Giaimo et al., 2018)

Su(H) - exd

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

Su(H) - htk

anti tag coimmunoprecipitation, western blot

(Singh et al., 2019)

Su(H) - insv

pull down, autoradiography, western blot

(Dai et al., 2013, Duan et al., 2011)

Su(H) - kto

anti bait coimmunoprecipitation, anti tag western blot

(Janody and Treisman, 2011)

Su(H) - l(3)mbt

pull down, autoradiography

(Xu et al., 2017)

Su(H) - lilli

pull down, molecular weight estimation by staining, anti tag coimmunoprecipitation, anti tag western blot

(Liu et al., 2017)

Su(H) - mam

protein three hybrid, anti tag coimmunoprecipitation, western blot, three hybrid, peptide massfingerprinting

(Gahr et al., 2019, Nagel et al., 2017, Yuan et al., 2016, Auer et al., 2015, Maier et al., 2011, Veraksa et al., 2005, Kitagawa et al., 2001, Petcherski and Kimble, 2000)

Su(H) - mirr

proximity ligation assay, fluorescence microscopy

(Shokri et al., 2019)

Su(H) - sd

(Wang et al., 2024)

Su(H) - skd

anti bait coimmunoprecipitation, anti tag western blot

(Janody and Treisman, 2011)

Su(H) - wap

anti tag coimmunoprecipitation, anti tag western blot

(Mo et al., 2023)

Su(H) - yki

proximity ligation assay, fluorescence microscopy

(Wang et al., 2024)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

arm

(Sanders et al., 2009)

suppressible

Cdk9

(Liu et al., 2017)

suppressible

(Fu and Baker, 2003)

enhanceable

CtBP

(Barolo et al., 2002)

suppressible

E(Egfr)B56

(Price et al., 1997)

suppressible

E(Egfr)C12

(Price et al., 1997)

suppressible

E(Egfr)C22

(Price et al., 1997)

suppressible

E(spl)m7-HLH

(Klein et al., 2000)

suppressible

E(spl)m8-HLH

(Klein et al., 2000)

suppressible

gro

(Price et al., 1997)

enhanceable

gro

(Barolo et al., 2002)

enhanceable

(Wolf et al., 2019, Furriols and Bray, 2000)

suppressible

(Smylla et al., 2019, Wolf et al., 2019, Kurth et al., 2011, Morel et al., 2001, Price et al., 1997)

enhanceable

insv

(Duan et al., 2011)

enhanceable

M285

(Go and Artavanis-Tsakonas, 1998)

enhanceable

mam

(Verheyen et al., 1996)

suppressible

mam

(Helms et al., 1999)

enhanceable

Mnr

(Nagel et al., 2021)

suppressible

Mnr

(Nagel et al., 2021)

enhanceable

(Furriols and Bray, 2000)

suppressible

(Liu et al., 2017)

suppressible

(Zaffran and Frasch, 2000)

suppressible

(Klein and Martinez Arias, 1998)

suppressible

(Price et al., 1997)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

aop

enhanceable

(Rohrbaugh et al., 2002)

csw

suppressible

(Oishi et al., 2006)

enhanceable

(Ma et al., 2009)

suppressible

(Jacobsen et al., 1998)

Delta

enhanceable

(Fortini and Artavanis-Tsakonas, 1994)

suppressible

(Fuwa et al., 2006, Koelzer and Klein, 2006)

enhanceable

(Fuwa et al., 2006)

Eogt|Dcr-2

suppressible

(Müller et al., 2013)

Eps-15

suppressible

(Tang et al., 2005)

eyg

suppressible

(Chao et al., 2004)

fred

enhanceable

(Chandra et al., 2003)

fred

suppressible

(Chandra et al., 2003)

gcm

suppressible

(Popkova et al., 2012)

enhanceable

(Mönch et al., 2024, Smylla et al., 2019, Wolf et al., 2019, Kurth et al., 2011, Nagel et al., 2005, Morel et al., 2001, Verheyen et al., 1996, Fortini and Artavanis-Tsakonas, 1994, Schweisguth and Posakony, 1992)

suppressible

(Mönch et al., 2024, Wolf et al., 2019, Maier et al., 2013, Morel and Schweisguth, 2000, Verheyen et al., 1996, Furukawa et al., 1992, Schweisguth and Posakony, 1992, O'Donnell et al., 1977)

ham

enhanceable

(Endo et al., 2011)

lace

suppressible

(Sasamura et al., 2013)

mam

enhanceable

(Helms et al., 1999, Fortini and Artavanis-Tsakonas, 1994)

suppressible

(Kuzina et al., 2011, San-Juán and Baonza, 2011, Rollins et al., 1999, Matsuno et al., 1997, Schweisguth et al., 1996, Verheyen et al., 1996)

enhanceable

(Ramain et al., 2001, Rollins et al., 1999, Royet et al., 1998, Matsuno et al., 1997, Verheyen et al., 1996, Fortini and Artavanis-Tsakonas, 1994)

suppressible

(Lee et al., 2013)

suppressible

(Xu et al., 2017)

suppressible

(Wang et al., 1997)

suppressible

(Saj et al., 2010)

suppressible

(Luo et al., 2025)

suppressible

(Koelzer and Klein, 2006)

enhanceable

(Shamloula et al., 2002)

Src42A

suppressible