FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Pi3K92E
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General Information
Symbol
Dmel\Pi3K92E
Species
D. melanogaster
Name
Phosphatidylinositol 3-kinase 92E
Annotation Symbol
CG4141
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015279
Gene Model Status
Current
Stock Availability
30 publicly available
Enzyme Name (EC)
phosphatidylinositol 3-kinase (2.7.1.137)
phosphatidylinositol-4,5-bisphosphate 3-kinase (2.7.1.153)
phosphatidylinositol-4-phosphate 3-kinase (2.7.1.154)
Gene Summary
Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Dp110, PI3K, p110, dPI3K, phosphoinositide 3-kinase

Key Links
Genomic Location
Cytogenetic map
92F3-92F3
Sequence location
Recombination map
3-69
RefSeq locus
NT_033777 REGION:20628972..20634732
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (58 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables 1-phosphatidylinositol-3-kinase activity
inferred from direct assay
(Orme et al., 2006, Weinkove et al., 1997, Leevers et al., 1996)
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
inferred from direct assay
(Orme et al., 2006, Leevers et al., 1996)
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity
inferred from direct assay
(Orme et al., 2006, Leevers et al., 1996)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables 1-phosphatidylinositol-3-kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(GO Reference Genome Project, 2011-)
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(GO Reference Genome Project, 2011-)
enables kinase activity
inferred from electronic annotation with InterPro:IPR018936
(InterPro Project Members, 2004-)
Biological Process (50 terms)
Terms Based on Experimental Evidence (47 terms)
CV Term
Evidence
References
involved_in autophagy
inferred from mutant phenotype
(Rusten et al., 2004)
involved_in carbohydrate homeostasis
inferred from mutant phenotype
(Murillo-Maldonado et al., 2011)
involved_in cell competition in a multicellular organism
inferred from mutant phenotype
(Levayer et al., 2015)
involved_in cellular response to starvation
inferred from mutant phenotype
(Wu et al., 2009)
involved_in dendrite morphogenesis
inferred from direct assay
(Martin-Pena et al., 2006)
involved_in entry into diapause
inferred from mutant phenotype
(Williams et al., 2006)
involved_in female germ-line stem cell population maintenance
inferred from mutant phenotype
(Su et al., 2018)
involved_in follicle cell of egg chamber development
inferred from mutant phenotype
(Jia et al., 2015)
involved_in glucose homeostasis
inferred from mutant phenotype
(Ugrankar et al., 2015)
involved_in hemocyte migration
inferred from mutant phenotype
(Wood et al., 2006)
involved_in instar larval development
inferred from mutant phenotype
(Caldwell et al., 2005)
involved_in insulin receptor signaling pathway
inferred from mutant phenotype
(Zhang et al., 2011, Kockel et al., 2010, Miron et al., 2003, Britton et al., 2002, Radimerski et al., 2002, Clemens et al., 2000)
inferred from direct assay
(Scanga et al., 2000)
involved_in intestinal stem cell homeostasis
inferred from genetic interaction with FLYBASE:mir-305; FB:FBgn0262458
(Foronda et al., 2014)
involved_in larval development
inferred from mutant phenotype
(Mirth et al., 2005)
involved_in larval feeding behavior
inferred from mutant phenotype
(Wu et al., 2005)
involved_in lipid homeostasis
inferred from mutant phenotype
(Murillo-Maldonado et al., 2011, Britton et al., 2002)
involved_in lymph gland development
inferred from mutant phenotype
(Benmimoun et al., 2012)
involved_in metamorphosis
inferred from mutant phenotype
(Mirth et al., 2005)
involved_in multicellular organism growth
inferred from mutant phenotype
(Murillo-Maldonado et al., 2011)
involved_in negative regulation of feeding behavior
inferred from mutant phenotype
(Britton et al., 2002)
involved_in oogenesis
inferred from mutant phenotype
(Orme et al., 2006)
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferred from mutant phenotype
(Britton et al., 2002, Clemens et al., 2000)
inferred from mutant phenotype
(Oswald et al., 2018)
involved_in phosphatidylinositol phosphate biosynthetic process
inferred from direct assay
(Weinkove et al., 1997, Leevers et al., 1996)
involved_in positive regulation of border follicle cell migration
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Sharma et al., 2018)
involved_in positive regulation of cell growth
inferred from genetic interaction with FLYBASE:Pi3K21B; FB:FBgn0020622,FLYBASE:Pten; FB:FBgn0026379
(Britton et al., 2002)
inferred from mutant phenotype
(Roth et al., 2018)
involved_in positive regulation of cell size
inferred from mutant phenotype
(Denton et al., 2012)
inferred from direct assay
(Parisi et al., 2011)
inferred from genetic interaction with FLYBASE:Raf; FB:FBgn0003079
(Sims et al., 2009)
involved_in positive regulation of crystal cell differentiation
inferred from mutant phenotype
(Benmimoun et al., 2012)
involved_in positive regulation of imaginal disc growth
inferred from mutant phenotype
(Gerlach et al., 2018, Orme et al., 2006, Leevers et al., 1996)
involved_in positive regulation of lamellocyte differentiation
inferred from mutant phenotype
(Benmimoun et al., 2012)
involved_in positive regulation of lipid storage
inferred from mutant phenotype
(Cinnamon et al., 2016, Britton et al., 2002)
involved_in positive regulation of neuron remodeling
inferred from mutant phenotype
(Wong et al., 2013)
acts_upstream_of positive regulation of organ growth
inferred from mutant phenotype
(Scanga et al., 2000)
involved_in positive regulation of organ growth
inferred from mutant phenotype
(Leevers et al., 1996)
involved_in positive regulation of plasmatocyte differentiation
inferred from mutant phenotype
(Benmimoun et al., 2012)
involved_in positive regulation of synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(Dimitroff et al., 2012)
inferred from direct assay
(Martin-Pena et al., 2006)
involved_in positive regulation of TORC1 signaling
inferred from mutant phenotype
(Kim et al., 2017)
involved_in positive regulation of translation
inferred from mutant phenotype
(Hall et al., 2007)
involved_in regulation of cell population proliferation
inferred from mutant phenotype
(Weinkove et al., 1999)
involved_in regulation of cell size
inferred from mutant phenotype
(Weinkove et al., 1999)
involved_in regulation of dendrite development
inferred from mutant phenotype
(Parrish et al., 2009)
involved_in regulation of long-term neuronal synaptic plasticity
inferred from direct assay
(Martin-Pena et al., 2006)
involved_in regulation of mitotic cell cycle
inferred from mutant phenotype
(Willecke et al., 2011)
involved_in regulation of multicellular organism growth
inferred from mutant phenotype
(Caldwell et al., 2005, Mirth et al., 2005)
involved_in regulation of synapse structural plasticity
inferred from mutant phenotype
(Mozer and Sandstrom, 2012)
involved_in regulation of synaptic plasticity
inferred from mutant phenotype
(Oswald et al., 2018)
inferred from genetic interaction with UniProtKB:Q9VA37
(Oswald et al., 2018)
involved_in response to oxidative stress
inferred from mutant phenotype
(Yang et al., 2005)
involved_in synapse maturation
inferred from direct assay
(Martin-Pena et al., 2006)
involved_in vascular endothelial growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006
(Read, 2018)
inferred from genetic interaction with FLYBASE:Raf; FB:FBgn0003079
(Sims et al., 2009)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in cell migration
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(GO Reference Genome Project, 2011-)
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(GO Reference Genome Project, 2011-)
involved_in phosphatidylinositol phosphate biosynthetic process
inferred from electronic annotation with InterPro:IPR015433
(InterPro Project Members, 2004-)
involved_in phosphatidylinositol-3-phosphate biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(GO Reference Genome Project, 2011-)
involved_in phosphatidylinositol-mediated signaling
inferred from biological aspect of ancestor with PANTHER:PTN000005673
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of phosphatidylinositol 3-kinase complex, class IA
inferred from direct assay
(Weinkove et al., 1997)
inferred from physical interaction with FLYBASE:Pi3K21B; FB:FBgn0020622
(Leevers et al., 1996)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000005673
(GO Reference Genome Project, 2011-)
part_of phosphatidylinositol 3-kinase complex
inferred from biological aspect of ancestor with PANTHER:PTN000799655
(GO Reference Genome Project, 2011-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
1-phosphatidylinositol-3-kinase activity
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl- sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) (2.7.1.137)
RHEA 12709: 1-phosphatidylinositol-4-phosphate 3-kinase activity
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) (2.7.1.154)
RHEA 18373: 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + ADP + H(+) (2.7.1.153)
RHEA 21292:
Summaries
Gene Snapshot
Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth. [Date last reviewed: 2018-09-13]
Pathway (FlyBase)
INSULIN-LIKE RECEPTOR SIGNALING PATHWAY CORE COMPONENTS -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
PVR SIGNALING PATHWAY CORE COMPONENTS -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Gene Group (FlyBase)
CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE COMPLEX -
Class IA phosphoinositide 3-kinase (PI3K) is a heterodimeric complex of a regulatory and catalytic subunit and is a core component of many many signaling pathways. In vitro, PI3Ks can phosphorylate phosphatidylinositol (PtdIns), PtdIns(4)P and PtdIns(4,5)P2 to generate PtdIns(3)P, PtdIns(3,4)P2 and PtdIns(3,4,5)P3, respectively. (Adapted from PMID:24587488 and FBrf0227909).
PHOSPHATIDYLINOSITOL 3 KINASES -
Phosphatidylinositol 3 kinases catalyze the phosphorylation of phosphatidylinositol (PI), or specific mono or bisphosphate derivatives of PI, at position 3 on the inositol ring to generate PI3P, PI(3,4)P[[2]] or PI(3,4,5)P[[3]]. The resulting phosphoinositides can act as signalling molecules to mediate/regulate a range of cellular and physiological processes, including cell polarity, cell migration, autophagy, growth, development, and ageing. (Adapted from FBrf0227909.)
Summary (Interactive Fly)

an enzyme that synthesizes phosphatidylinositide lipids, which act as signals essential for growth - a target of the insulin pathway

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Pi3K92E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P91634)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pi3K92E-RA
FBtr0083940
NM_142645
4420
1088
Pi3K92E-RB
FBtr0083941
NM_169910
4347
1088
Pi3K92E-RC
FBtr0334643
NM_001275841
4839
1088
Additional Transcript Data and Comments
Reported size (kB)

3.712 (compiled cDNA)

(Leevers et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Pi3K92E-PA
FBpp0083348
127.0
1088
7.62
P91634
NP_650902
AAF55792
Pi3K92E-PB
FBpp0083349
127.0
1088
7.62
P91634
NP_732536
AAN14359
Pi3K92E-PC
FBpp0306705
127.0
1088
7.62
P91634
NP_001262770
AGB96150
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1088 aa isoforms: Pi3K92E-PA, Pi3K92E-PB, Pi3K92E-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

1088 (aa); 127 (kD predicted)

(Leevers et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pi3K92E using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.02

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 2
organism | ubiquitous
(Xi et al., 2014)
embryonic stage 6
ventral furrow
(Xi et al., 2014)
embryonic stage 10 -- 12
organism | ubiquitous
(Xi et al., 2014)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of phosphatidylinositol 3-kinase complex, class IA
inferred from direct assay
(Weinkove et al., 1997)
inferred from physical interaction with FLYBASE:Pi3K21B; FB:FBgn0020622
(Leevers et al., 1996)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pi3K92E in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 32 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pi3K92E
Transgenic constructs containing regulatory region of Pi3K92E
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PP
lethal, with Scer\GAL4hs.PB
lethal | recessive
partially lethal - majority die, with Scer\GAL4en-e16E
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Adh.PF
viable, with Scer\GAL4en-e16E
viable, with Scer\GAL4repo.PU
viable, with Scer\GAL4tin.CΔ4
viable (with Pi3K92E2H1)
viable (with Pi3K92E5W3)
viable (with Pi3K92EA)
viable | RU486 conditional, with Scer\GAL4da.Switch.PT
Sterility
Allele
female sterile (with Pi3K92E6M5)
female sterile (with Pi3K92E6V2)
fertile, with Scer\GAL4Adh.PF
fertile, with Scer\GAL4en-e16E
Other Phenotypes
Allele
abnormal cell death | embryonic stage, with Scer\GAL4unspecified
abnormal cell growth, with Scer\GAL4P0206
abnormal cell growth | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
abnormal cell growth | somatic clone, with Scer\GAL4Act5C.PP
abnormal cell migration | larval stage, with Scer\GAL4repo
abnormal cell shape, with Scer\GAL4Cg.PU
abnormal cell size, with Scer\GAL4amn-c651
abnormal cell size, with Scer\GAL4ccb-796
abnormal cell size, with Scer\GAL4phtm.PO
abnormal developmental rate, with Scer\GAL4amn-c651
abnormal developmental rate, with Scer\GAL4arm.PS
abnormal developmental rate, with Scer\GAL4P0206
abnormal developmental rate, with Scer\GAL4phtm.PO
abnormal developmental rate, with Scer\GAL4phtm.PU
abnormal developmental rate | third instar larval stage, with Scer\GAL4amn-c651
abnormal developmental rate | third instar larval stage, with Scer\GAL4amn-X8
abnormal endomitotic cell cycle | larval stage | nutrition conditional, with Scer\GAL4Desat1.PB
abnormal feeding behavior, with Scer\GAL4Adh.PF
abnormal feeding behavior, with Scer\GAL4NPFR.6.6
abnormal locomotor behavior, with Scer\GAL4ccb-796
abnormal locomotor behavior | adult stage, with Scer\GAL4Mef2.PR
abnormal neuroanatomy, with Scer\GAL4C57
abnormal neuroanatomy, with Scer\GAL4ccb-796
abnormal neuroanatomy, with Scer\GAL4GH298
abnormal neuroanatomy, with Scer\GAL4GH298, Scer\GAL4kra-krasavietz
abnormal neuroanatomy, with Scer\GAL4GH298, Scer\GAL80ChAT.3.3P
abnormal neuroanatomy, with Scer\GAL4kra-krasavietz
abnormal neuroanatomy, with Scer\GAL4kra-krasavietz, Scer\GAL80Mef2.mb247
abnormal neuroanatomy, with Scer\GAL4Mef2.247
abnormal neuroanatomy, with Scer\GAL4ppk.PG
abnormal neuroanatomy, with Scer\GAL4smid-C161
abnormal neuroanatomy, with Scer\GAL4Toll-6-D42
abnormal neuroanatomy | adult stage, with Scer\GAL4pnr-MD237
abnormal neuroanatomy | adult stage | somatic clone
abnormal neuroanatomy | larval stage, with Scer\GAL4ppk.PG
abnormal neuroanatomy | larval stage, with Scer\GAL4repo
abnormal neuroanatomy | pupal stage, with Scer\GAL4ppk.PG
abnormal neuroanatomy | somatic clone, with Scer\GAL4VGlut1-OK371
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4Gli-rL82
abnormal neurophysiology, with Scer\GAL4C57
abnormal neurophysiology, with Scer\GAL4elav.PLu
abnormal neurophysiology, with Scer\GAL4Toll-6-D42
abnormal neurophysiology | adult stage (with Pi3K92E2H1)
abnormal neurophysiology | adult stage (with Pi3K92E5W3)
abnormal neurophysiology | adult stage (with Pi3K92EA)
abnormal neurophysiology | adult stage | recessive
abnormal neurophysiology | third instar larval stage, with Scer\GAL4nSyb.PS
abnormal planar polarity | embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
abnormal planar polarity | recessive | somatic clone
abnormal planar polarity | somatic clone, with Scer\GAL4Act5C.PP
abnormal size, with Scer\GAL4ap-md544
abnormal size, with Scer\GAL4Bx-MS1096
abnormal size, with Scer\GAL4en-e16E
abnormal size, with Scer\GAL4nub-AC-62
abnormal size | adult stage, with Scer\GAL4en-e16E
abnormal size | adult stage, with Scer\GAL4eya.enh1+E+2
abnormal size | adult stage, with Scer\GAL4pnr-MD237
abnormal size | adult stage, with Scer\GAL4ptc.PU
abnormal size | cell autonomous, with Scer\GAL4dpp.blk1
abnormal size | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
abnormal size | cell non-autonomous, with Scer\GAL4dpp.blk1
abnormal size | third instar larval stage, with Scer\GAL4hh.PU
abnormal smell perception, with Scer\GAL4GH298
abnormal smell perception, with Scer\GAL4GH298, Scer\GAL80ChAT.3.3P
abnormal smell perception, with Scer\GAL4kra-krasavietz
abnormal smell perception, with Scer\GAL4kra-krasavietz, Scer\GAL80Mef2.mb247
abnormal starvation stress response | adult stage, with Scer\GAL4elav-C155
abnormal starvation stress response | larval stage | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
abnormal starvation stress response | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PP
abnormal stress response, with Scer\GAL4en-e16E
abnormal wound healing, with Scer\GAL4crq.PO
abnormal wound healing | larval stage, with Scer\GAL4repo
chemical resistant, with Scer\GAL4elav-C155
chemical resistant | adult stage | heat sensitive, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B
chemical resistant | RU486 conditional, with Scer\GAL4da.Switch.PT
chemical sensitive, with Scer\GAL4elav-C155
decreased body size, with Scer\GAL4P0206
decreased body size (with Pi3K92E2H1)
decreased body size (with Pi3K92EA)
decreased body size | adult stage, with Scer\GAL4ppl.PP
decreased body size | adult stage (with Pi3K92E2H1)
decreased body size | adult stage (with Pi3K92E5W3)
decreased body size | adult stage (with Pi3K92EA)
decreased body size | adult stage | recessive
decreased body size | nutrition conditional, with Scer\GAL4ppl.PP
decreased body size | pharate adult stage, with Scer\GAL4P0206
decreased body size | pupal stage, with Scer\GAL4amn-c651
decreased body size | second instar larval stage, with Scer\GAL4phtm.PO
decreased body size | somatic clone
decreased body size | third instar larval stage, with Scer\GAL4phtm.PO
decreased body weight | adult stage, with Scer\GAL4ppl.PP
decreased cell death, with Scer\GAL4hs.PB
decreased cell growth rate, with Scer\GAL4en.PU
decreased cell number, with Scer\GAL4dpp.blk1
decreased cell number, with Scer\GAL4GMR.PF
decreased cell number, with Scer\GAL4nub-AC-62
decreased cell number, with Scer\GAL4P0206
decreased cell number | larval stage, with Scer\GAL4sns.PU
decreased cell number | somatic clone | spermatogenesis, with Scer\GAL4NP1624
decreased cell number | third instar larval stage, with Scer\GAL4repo.PU
decreased cell size, with Scer\GAL4ap-md544
decreased cell size, with Scer\GAL4Bx-MS1096
decreased cell size, with Scer\GAL4dpp.blk1
decreased cell size, with Scer\GAL4GMR.PF
decreased cell size, with Scer\GAL4nub-AC-62
decreased cell size, with Scer\GAL4P0206
decreased cell size, with Scer\GAL4ppl.PP
decreased cell size | larval stage, with Scer\GAL4Desat1.PB
decreased cell size | larval stage, with Scer\GAL4sns.PU
decreased cell size | larval stage | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
decreased cell size | recessive | somatic clone
decreased efficacy of long-term memory | adult stage, with Scer\GAL4GMR54H02
decreased fecundity | female | RU486 conditional, with Scer\GAL4da.Switch.PT
decreased occurrence of cell division | adult stage | RU486 conditional, with Scer\GAL4bun-GSG5961
decreased occurrence of cell division | larval stage, with Scer\GAL4nab
decreased occurrence of cell division | oogenesis, with Scer\GAL4nanos.PU
decreased occurrence of cell division | second instar larval stage, with Scer\GAL4repo.PU
decreased size | adult stage, with Scer\GAL4salm.EPv
decreased size | third instar larval stage, with Scer\GAL4repo.PU
hyperplasia, with Scer\GAL4GMR.PF
hyperplasia, with Scer\GAL4nub-AC-62
hyperplasia | larval stage, with Scer\GAL4repo
increased body size, with Scer\GAL4P0206
increased body size | adult stage, with Scer\GAL4amn-c651
increased body size | pupal stage, with Scer\GAL4amn-c651
increased body size | pupal stage, with Scer\GAL4amn-X8
increased cell death | third instar larval stage, with Scer\GAL4en-e16E
increased cell growth rate, with Scer\GAL4e22c
increased cell growth rate, with Scer\GAL4GMR.PF
increased cell number, with Scer\GAL4ccb-796
increased cell number, with Scer\GAL4dpp.blk1
increased cell number, with Scer\GAL4P0206
increased cell number | adult stage, with Scer\GAL4da.PU
increased cell number | adult stage, with Scer\GAL4dpp.blk1
increased cell size, with Scer\GAL4AB1
increased cell size, with Scer\GAL4Bx-MS1096
increased cell size, with Scer\GAL4dpp.blk1
increased cell size | adult stage, with Scer\GAL4dpp.blk1
increased cell size | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
increased cell size | larval stage, with Scer\GAL4Desat1.PB
increased cell size | larval stage, with Scer\GAL4sns.PU
increased cell size | larval stage | somatic clone | nutrition conditional, with Scer\GAL4FRT.Rnor\Cd2.Act5C
increased cell size | somatic clone, with Scer\GAL4Act5C.PP
increased cell size | somatic clone, with Scer\GAL4αTub84B.PP
increased cell size | third instar larval stage, with Scer\GAL4ppl.PP
increased occurrence of cell division | larval stage, with Scer\GAL4nab
increased occurrence of cell division | oogenesis, with Scer\GAL4nanos.PU
increased occurrence of cell division | third instar larval stage, with Scer\GAL4bi-omb-Gal4
increased size | adult stage, with Scer\GAL4bi-omb-Gal4
increased size | spermatogenesis, with Scer\GAL4VP16.bam
increased size | third instar larval stage, with Scer\GAL4en.PU
long lived | RU486 conditional, with Scer\GAL4bun-GSG5961
long lived | RU486 conditional, with Scer\GAL4da.Switch.PT
photoperiod response variant, with Scer\GAL4phtm.PO
short lived, with Scer\GAL4da.PU
short lived, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
some die during larval stage, with Scer\GAL4en-e16E
some die during pupal stage, with Scer\GAL4en-e16E
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4en-e16E
visible | adult stage, with Scer\GAL4salm.EPv
visible | adult stage (with Pi3K92E2H1)
visible | adult stage (with Pi3K92E5W3)
visible | adult stage | recessive
visible | embryonic stage, with Scer\GAL4unspecified
visible | somatic clone
wild-type
Phenotype manifest in
Allele
adult gut, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
adult gut | RU486 conditional, with Scer\GAL4bun-GSG5961
adult head capsule | somatic clone
adult mushroom body, with Scer\GAL4kra-krasavietz, Scer\GAL80ple.PK
adult mushroom body, with Scer\GAL4Tab2-201Y
antennal lobe, with Scer\GAL4GH298
antennal lobe, with Scer\GAL4GH298, Scer\GAL4kra-krasavietz
antennal lobe, with Scer\GAL4kra-krasavietz
antennal lobe glomerulus DM2, with Scer\GAL4GH298
antennal lobe glomerulus DM2, with Scer\GAL4GH298, Scer\GAL4kra-krasavietz
antennal lobe glomerulus DM2, with Scer\GAL4kra-krasavietz
autolysosome | third instar larval stage, with Scer\GAL4Act5C.PP
autophagosome, with Scer\GAL4Lsp2.PH
axon, with Scer\GAL4Toll-6-D42
Bolwig nerve, with Scer\GAL4repo
bouton, with Scer\GAL4C57
bouton, with Scer\GAL4Toll-6-D42
bouton | increased number, with Scer\GAL4ccb-796
cell body, with Scer\GAL4smid-C161
cell body | somatic clone, with Scer\GAL4VGlut1-OK371
cell surface & nurse cell | somatic clone, with Scer\GAL4Act5C.PP
chaeta, with Scer\GAL4ap-md544
chromosome | larval stage, with Scer\GAL4Act.PU
chromosome | larval stage, with Scer\GAL4ppl.PP
dendrite, with Scer\GAL4ccb-796
dendrite, with Scer\GAL4smid-C161
dendrite | adult stage | somatic clone
dendrite | larval stage, with Scer\GAL4ppk.PG
dendrite | somatic clone, with Scer\GAL4VGlut1-OK371
distal medullary amacrine neuron Dm8a | adult stage | somatic clone
egg chamber | germline clone
ellipsoid body, with Scer\GAL4ccb-796
embryo | dorsal closure stage
embryo | dorsal closure stage, with Scer\GAL4en.PU
embryo | maternal effect, with Scer\GAL4VP16.mat.αTub67C
embryonic/first instar larval cuticle, with Scer\GAL4unspecified
embryonic/larval epidermis | somatic clone, with Scer\GAL4Act5C.PP
embryonic/larval fat body | larval stage | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
embryonic/larval fat body | larval stage | somatic clone | nutrition conditional, with Scer\GAL4FRT.Rnor\Cd2.Act5C
embryonic/larval fat body | somatic clone, with Scer\GAL4Act5C.PP
embryonic/larval fat body | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PU
embryonic/larval fat body | third instar larval stage, with Scer\GAL4Act5C.PP
embryonic/larval garland cell | decreased number | larval stage, with Scer\GAL4sns.PU
embryonic/larval garland cell | larval stage, with Scer\GAL4sns.PU
embryonic/larval gut | third instar larval stage, with Scer\GAL4Act5C.PP
embryonic/larval Malpighian tubule | somatic clone, with Scer\GAL4Act5C.PP
embryonic/larval neuromuscular junction, with Scer\GAL4elav.PLu
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4nSyb.PS
embryonic/larval oenocyte | larval stage, with Scer\GAL4Desat1.PB
embryonic/larval oenocyte | larval stage | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
embryonic/larval optic stalk, with Scer\GAL4repo
embryonic/larval plasmatocyte | ectopic, with Scer\GAL4Gli-rL82
embryonic/larval salivary gland, with Scer\GAL429BD
embryonic/larval salivary gland, with Scer\GAL4AB1
embryonic/larval salivary gland, with Scer\GAL4fkh.PH
embryonic/larval salivary gland, with Scer\GAL4hs.PB
embryonic/larval salivary gland, with Scer\GAL4nub-AC-62
embryonic/larval salivary gland, with Scer\GAL4ppl.PP
embryonic/larval salivary gland | third instar larval stage, with Scer\GAL4ppl.PP
embryonic leading edge cell
embryonic leading edge cell, with Scer\GAL4en.PU
eye, with Scer\GAL4Bx-MS1096
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4eya.enh1+E+2
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4P0206
eye disc | larval stage, with Scer\GAL4repo
eye disc | somatic clone, with Scer\GAL4Act5C.PP
fat body
fat body, with Scer\GAL4Act5C.PP
fat body | somatic clone, with Scer\GAL4αTub84B.PP
fat cell | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
first posterior wing cell, with Scer\GAL4dpp.blk1
first posterior wing cell, with Scer\GAL4ptc-559.1
gastric caecum | somatic clone, with Scer\GAL4Act5C.PP
germ band, with Scer\GAL4Kr.PM
hemocyte, with Scer\GAL4Cg.PU
imaginal disc
imaginal disc & cell, with Scer\GAL4Act5C.PP
interneuron, with Scer\GAL4GH298
interneuron, with Scer\GAL4GH298, Scer\GAL4kra-krasavietz
interneuron, with Scer\GAL4kra-krasavietz
interneuron, with Scer\GAL4Mef2.247
interommatidial bristle, with Scer\GAL4GMR.PF
interommatidial bristle | P-stage, with Scer\GAL4ey.PH
interommatidial cell | P-stage, with Scer\GAL4ey.PH
intestinal stem cell | adult stage, with Scer\GAL4NP0677
larva
larval brain | larval stage, with Scer\GAL4Act.PU
larval brain | third instar larval stage, with Scer\GAL4repo.PU
larval digestive system | somatic clone, with Scer\GAL4Act5C.PP
larval dorsal multidendritic neuron ddaC, with Scer\GAL4smid-C161
larval dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4ppk.PG
larval glial cell, with Scer\GAL4repo
larval glial cell | decreased number | third instar larval stage, with Scer\GAL4repo.PU
larval multidendritic class IV neuron, with Scer\GAL4ppk.PG
larval multidendritic class IV neuron, with Scer\GAL4repo
larval neuroblast, with Scer\GAL4Act.PU
larval neuroblast, with Scer\GAL4nab
larval neuroblast, with Scer\GAL4ppl.PP
larval neuroblast, with Scer\GAL4repo.PU
larval peripheral nervous system | third instar larval stage, with Scer\GAL4Gli-rL82
lysosome, with Scer\GAL4Lsp2.PH
mechanosensory neuron of posterior dorsocentral bristle, with Scer\GAL4pnr-MD237
mesonotum, with Scer\GAL4ap-md544
mesonotum, with Scer\GAL4pnr-MD237
mesonotum | pupal stage | somatic clone, with Scer\GAL4FRT.Act5C
mitochondrion | P-stage, with Scer\GAL4phtm.PU
mitochondrion | P-stage | nutrition conditional, with Scer\GAL4phtm.PU
mitotic cell cycle | somatic clone, with Scer\GAL4Act5C.PP
motor neuron, with Scer\GAL4Toll-6-D42
motor neuron | somatic clone, with Scer\GAL4VGlut1-OK371
neuroblast | third instar larval stage | nutrition conditional, with Scer\GAL4insc-Mz1407
neuron | increased number, with Scer\GAL4ccb-796
neuron projection | adult stage, with Scer\GAL4pnr-MD237
neuropil | somatic clone, with Scer\GAL4VGlut1-OK371
nucleus | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
ommatidial precursor cluster | somatic clone, with Scer\GAL4Act5C.PP
ommatidium, with Scer\GAL4GMR.PF
ommatidium | P-stage, with Scer\GAL4ey.PH
ommatidium | P-stage | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
ommatidium | somatic clone
ovariole, with Scer\GAL4nanos.PU
ovary (with Pi3K92E6M5)
ovary (with Pi3K92E6V2)
prothoracic gland, with Scer\GAL4amn-c651
prothoracic gland, with Scer\GAL4P0206
prothoracic gland, with Scer\GAL4phtm.PO
prothoracic gland | P-stage, with Scer\GAL4phtm.PU
prothoracic gland | P-stage | nutrition conditional, with Scer\GAL4phtm.PU
puparium cuticle, with Scer\GAL4phtm.PO
ring canal, with Scer\GAL4P0206
slit diaphragm | decreased number | larval stage, with Scer\GAL4sns.PU
spermatocyte, with Scer\GAL4VP16.bam
synapse
synapse, with Scer\GAL4C57
synapse, with Scer\GAL4GH298
synapse, with Scer\GAL4GH298, Scer\GAL4kra-krasavietz
synapse, with Scer\GAL4kra-krasavietz
synapse, with Scer\GAL4Mef2.247
synapse, with Scer\GAL4Toll-6-D42
synapse | adult stage, with Scer\GAL4pnr-MD237
synapse | increased number, with Scer\GAL4ccb-796
synapse | increased number, with Scer\GAL4Toll-6-D42
testis | somatic clone, with Scer\GAL4NP1624
wing
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4bi-omb-Gal4
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4e22c
wing, with Scer\GAL4nub-AC-62
wing, with Scer\GAL4P0206
wing, with Scer\GAL4salm.EPv
wing, with Scer\GAL4αTub84B.PC
wing (with Pi3K92E2H1)
wing (with Pi3K92E5W3)
wing & cell, with Scer\GAL4dpp.blk1
wing | posterior, with Scer\GAL4en-e16E
wing blade, with Scer\GAL4ap-md544
wing blade, with Scer\GAL4ptc.PU
wing disc, with Scer\GAL429BD
wing disc, with Scer\GAL4dpp.blk1
wing disc | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PU
wing disc | third instar larval stage, with Scer\GAL4bi-omb-Gal4
wing disc | third instar larval stage, with Scer\GAL4en-e16E
wing disc posterior compartment, with Scer\GAL4en-e16E
wing disc posterior compartment | third instar larval stage, with Scer\GAL4en.PU
wing disc posterior compartment | third instar larval stage, with Scer\GAL4hh.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (20)
Hsap\PIK3CD
14 of 14
Yes
Yes
2  
Hsap\PIK3CB
12 of 14
No
Yes
1  
Hsap\PIK3CA
7 of 14
No
Yes
Hsap\PIK3CG
7 of 14
No
Yes
Hsap\PIK3C2A
4 of 14
No
No
Hsap\PIK3C2B
4 of 14
No
No
Hsap\PIK3C2G
4 of 14
No
No
Hsap\PIK3C3
3 of 14
No
No
Hsap\PI4KA
2 of 14
No
No
2  
Hsap\PI4KB
2 of 14
No
No
2  
Hsap\ATR
1 of 14
No
No
2  
Hsap\BOLA2
1 of 14
No
No
1  
Hsap\BOLA2-SMG1P6
1 of 14
No
Yes
Hsap\MTOR
1 of 14
No
No
1  
Hsap\PI4KAP2
1 of 14
No
No
Hsap\PRKDC
1 of 14
No
No
Hsap\SH3PXD2A
1 of 14
No
Yes
Hsap\SH3PXD2B
1 of 14
No
Yes
Hsap\SMG1
1 of 14
No
No
Hsap\TRRAP
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (13)
Rnor\Pik3cd
14 of 14
Yes
Yes
Rnor\Pik3cb
13 of 14
No
Yes
Rnor\Pik3ca
7 of 14
No
Yes
Rnor\Pik3cg
6 of 14
No
Yes
Rnor\Pik3c2a
4 of 14
No
No
Rnor\Pik3c2b
4 of 14
No
No
Rnor\Pik3c2g
4 of 14
No
No
Rnor\Pik3c3
3 of 14
No
No
Rnor\Pi4kb
2 of 14
No
No
Rnor\Atm
1 of 14
No
No
Rnor\Atr
1 of 14
No
No
Rnor\Mtor
1 of 14
No
No
Rnor\Pi4ka
1 of 14
No
No
Mus musculus (laboratory mouse) (17)
Mmus\Pik3cd
14 of 14
Yes
Yes
Mmus\Pik3cb
13 of 14
No
Yes
Mmus\Pik3ca
7 of 14
No
Yes
Mmus\Pik3cg
7 of 14
No
Yes
Mmus\Pik3c2a
4 of 14
No
No
Mmus\Pik3c2b
3 of 14
No
No
Mmus\Pik3c2g
3 of 14
No
No
Mmus\Pik3c3
3 of 14
No
No
Mmus\Pi4ka
2 of 14
No
No
Mmus\Pi4kb
2 of 14
No
No
Mmus\Atr
1 of 14
No
No
Mmus\Mtor
1 of 14
No
No
Mmus\Prkdc
1 of 14
No
No
Mmus\Sh3pxd2a
1 of 14
No
Yes
Mmus\Sh3pxd2b
1 of 14
No
Yes
Mmus\Smg1
1 of 14
No
No
Mmus\Trrap
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\pik3cb
7 of 13
Yes
Yes
Xtro\pik3ca
6 of 13
No
Yes
Xtro\pik3cg
3 of 13
No
Yes
Xtro\alox12b
1 of 13
No
Yes
Xtro\cpt1al
1 of 13
No
No
Xtro\map2k1
1 of 13
No
No
Xtro\pi4kb
1 of 13
No
No
Xtro\pik3c2a
1 of 13
No
No
Xtro\pik3c2b
1 of 13
No
No
Xtro\pik3c3
1 of 13
No
No
Xtro\slc25a28
1 of 13
No
No
Danio rerio (Zebrafish) (15)
Drer\pik3cd
14 of 14
Yes
Yes
Drer\pik3cb
13 of 14
No
Yes
Drer\zgc:158659
9 of 14
No
Yes
Drer\pik3ca
8 of 14
No
Yes
Drer\pik3cg
7 of 14
No
Yes
Drer\si:rp71-17i16.5
7 of 14
No
Yes
Drer\pik3c2a
4 of 14
No
No
Drer\pik3c2b
4 of 14
No
No
Drer\pik3c3
3 of 14
No
No
Drer\pi4kaa
2 of 14
No
No
Drer\pi4kb
2 of 14
No
No
Drer\pik3c2g
2 of 14
No
No
Drer\pi4kab
1 of 14
No
No
Drer\prkdc
1 of 14
No
No
Drer\smg1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\age-1
12 of 14
Yes
Yes
Cele\piki-1
3 of 14
No
No
Cele\pifk-1
2 of 14
No
No
Cele\vps-34
2 of 14
No
No
Cele\Y75B8A.24
2 of 14
No
No
Anopheles gambiae (African malaria mosquito) (11)
Agam\AgaP_AGAP000018
12 of 12
Yes
Yes
Agam\AgaP_AGAP010273
3 of 12
No
No
Agam\AgaP_AGAP011036
3 of 12
No
No
Agam\AgaP_AGAP010801
2 of 12
No
No
Agam\AgaP_AGAP000368
1 of 12
No
No
Agam\AgaP_AGAP003967
1 of 12
No
No
Agam\AgaP_AGAP005533
1 of 12
No
No
Agam\AgaP_AGAP007512
1 of 12
No
No
Agam\AgaP_AGAP007873
1 of 12
No
No
Agam\AgaP_AGAP010313
1 of 12
No
No
Agam\AgaP_AGAP012631
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (10)
Atha\VPS34
3 of 13
Yes
No
Atha\AT1G51040
2 of 13
No
No
Atha\ATPI4K ALPHA
2 of 13
No
No
Atha\PI-4KBETA1
2 of 13
No
No
Atha\PI-4KBETA2
2 of 13
No
No
Atha\AT2G17930
1 of 13
No
No
Atha\AT4G36080
1 of 13
No
No
Atha\ATM
1 of 13
No
No
Atha\ATR
1 of 13
No
No
Atha\TOR
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\PIK1
2 of 13
Yes
No
Scer\STT4
2 of 13
Yes
No
Scer\VPS34
2 of 13
Yes
No
Scer\MEC1
1 of 13
No
No
Scer\TOR1
1 of 13
No
No
Scer\TOR2
1 of 13
No
No
Scer\TRA1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (8)
Spom\pik1
2 of 12
Yes
No
Spom\pik3
2 of 12
Yes
No
Spom\stt4
2 of 12
Yes
No
Spom\rad3
1 of 12
No
No
Spom\tor1
1 of 12
No
No
Spom\tor2
1 of 12
No
No
Spom\tra1
1 of 12
No
No
Spom\tra2
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Pi3K92E. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (8)
Pi3K59F
5 of 13
Pi3K68D
5 of 13
fwd
4 of 13
Pi4KIIIα
4 of 13
CG30184
1 of 13
mei-41
1 of 13
mTor
1 of 13
nonC
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 10 )
Allele
Disease
Evidence
References
Pi3K92E2H1
model of  type 2 diabetes mellitus
CEA
(Murillo-Maldonado et al., 2011)
CEA with Pi3K92EA
(Murillo-Maldonado et al., 2011)
CEA with Pi3K92E5W3
(Murillo-Maldonado et al., 2011)
Pi3K92E5W3
model of  type 2 diabetes mellitus
CEA
(Murillo-Maldonado et al., 2011)
CEA with Pi3K92E2H1
(Murillo-Maldonado et al., 2011)
CEA with Pi3K92EA
(Murillo-Maldonado et al., 2011)
model of  glucose metabolism disease
CEA with Pi3K92EA
(Álvarez-Rendón and Riesgo-Escovar, 2020)
Pi3K92EA
model of  type 2 diabetes mellitus
CEA with Pi3K92E2H1
(Murillo-Maldonado et al., 2011)
CEA with Pi3K92E5W3
(Murillo-Maldonado et al., 2011)
model of  glucose metabolism disease
CEA with Pi3K92E5W3
(Álvarez-Rendón and Riesgo-Escovar, 2020)
Pi3K92EA2860C.UAS
model of  alcohol use disorder
CEA
(Eddison et al., 2011)
Pi3K92ECAAX.UAS
model of  high grade glioma
CEA with btl::Egfrλ.UAS
(Courant et al., 2022, Ariss et al., 2020)
CEA with EgfrAct.cUa.UAS
(Pryszlak et al., 2021)
model of  heart disease
CEA
(Karekar et al., 2021)
model of  glioblastoma
CEA with btl::Egfrλ.UAS
(Chi et al., 2019)
Pi3K92EUAS.Exel
model of  alcohol use disorder
CEA
(Eddison et al., 2011)
Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
model of  brain glioma
CEA with btl::Egfrλ.UAS
(Read et al., 2013, Read et al., 2009)
model of  high grade glioma
CEA with btl::Egfrλ.UAS
(Bertrand et al., 2023, Jarabo et al., 2022, Jarabo et al., 2022, Losada-Pérez et al., 2022, Conte et al., 2021, Jarabo et al., 2021, Maravat et al., 2021, Vigneswaran et al., 2021, Portela et al., 2020, Chen et al., 2019, Portela et al., 2019, Portela et al., 2019, Agnihotri et al., 2016)
CEA with Hsap\EGFRΔ.UAS
(Formica et al., 2021, Terrasi et al., 2019)
CEA
(Bertrand et al., 2023)
model of  cancer
CEA
(Wang et al., 2023, Ganguly et al., 2021, Sollazzo et al., 2018)
CEA with Hsap\RAF1gof.UAS
(Wang et al., 2023)
model of  glioblastoma
CEA with btl::Egfrλ.UAS
(Park et al., 2017)
model of  neurodegenerative disease
CEA with btl::Egfrλ.UAS
(Jarabo et al., 2022)
CEA with cryUAS.cEa
(Jarabo et al., 2022)
Pi3K92EGD11228
model of  glucose metabolism disease
CEA
(Mascolo et al., 2022)
Pi3K92EKK102291
model of  glucose metabolism disease
CEA
(Mascolo et al., 2022)
Pi3K92EUAS.cUa
model of  high grade glioma
CEA
(Witte et al., 2009)
Potential Models Based on Orthology ( 12 )
Modifiers Based on Experimental Evidence ( 8 )
Allele
Disease
Interaction
References
Pi3K92ECAAX.UAS
exacerbates  high grade glioma
modeled by aPKCUAS.Tag:CAAX(Unk)
(Paglia et al., 2017)
ameliorates  Huntington's disease
modeled by Hsap\HTTQ138.UAS.mRFP1
(Hansen et al., 2019)
ameliorates  type 2 diabetes mellitus
modeled by UchKO
(Lee et al., 2024)
Pi3K92ED954A.UAS.Tag:MYC
ameliorates  cancer
modeled by dlg1GD4689, Ras85DV12.UAS
(Katheder et al., 2017)
exacerbates  Parkinson's disease
modeled by DJ-1αRNAi.UAS
(Yang et al., 2005)
exacerbates  Huntington's disease
modeled by Hsap\HTTQ138.UAS.mRFP1
(Hansen et al., 2019)
ameliorates  high grade glioma
modeled by Wdr62UAS.Tag:HA
(Shohayeb et al., 2020)
ameliorates  fragile X syndrome
modeled by Fmr13
(Monyak et al., 2017)
Pi3K92EUAS.Tag:MYC
ameliorates  Parkinson's disease
modeled by DJ-1αRNAi.UAS
(Yang et al., 2005)
exacerbates  autosomal dominant cerebellar ataxia
modeled by Hsap\ATXN182Q.UAS
(Chen et al., 2003)
ameliorates  Huntington's disease
modeled by Hsap\HTT128Q.1-336.UAS
(Branco et al., 2008)
exacerbates  olivopontocerebellar atrophy
modeled by Hsap\ATXN182Q.UAS
(Branco et al., 2008)
exacerbates  Alzheimer's disease 1
modeled by Hsap\APPAβ42.UAS.cUa
(Cheng et al., 2021)
ameliorates  Alzheimer's disease 1
modeled by Hsap\APPAβ42.UAS.Tag:SS(nec)
(López-Arias et al., 2017)
Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
ameliorates  cancer
modeled by MycαTub84B.PBb
(Levayer et al., 2015)
ameliorates  obesity
modeled by Itprka1091, Itprug3
(Subramanian et al., 2013)
model of  high grade glioma
is ameliorated by Hsap\HTR7UAS.Tag:FLAG
(Bertrand et al., 2023)
model of  cancer
is exacerbated by Hsap\PTEN4A.UAS
(Ganguly et al., 2021)
is ameliorated by Hsap\PTENC124R.UAS
(Ganguly et al., 2021)
is ameliorated by Hsap\PTEND107V.UAS
(Ganguly et al., 2021)
is ameliorated by Hsap\PTENF241S.UAS
(Ganguly et al., 2021)
is ameliorated by Hsap\PTENG129E.UAS
(Ganguly et al., 2021)
is ameliorated by Hsap\PTENH93R.UAS
(Ganguly et al., 2021)
is ameliorated by Hsap\PTENM35V.UAS
(Ganguly et al., 2021)
is ameliorated by Hsap\PTENP246L.UAS
(Ganguly et al., 2021)
is ameliorated by Hsap\PTENR130Q.UAS
(Ganguly et al., 2021)
is ameliorated by Hsap\PTENT131I.UAS
(Ganguly et al., 2021)
is ameliorated by Hsap\PTENT167N.UAS
(Ganguly et al., 2021)
is ameliorated by Hsap\PTENUAS.cPa
(Ganguly et al., 2021)
is ameliorated by Hsap\PTENY138L.UAS
(Ganguly et al., 2021)
is ameliorated by Hsap\PTENY27C.UAS
(Ganguly et al., 2021)
Pi3K92EGD11228
ameliorates  cancer
modeled by Ras85DV12.UAS, dlg1GD4689
(Willecke et al., 2011)
ameliorates  high grade glioma
modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), btl::Egfrλ.UAS
(Losada-Pérez et al., 2022)
Pi3K92EKK102291
exacerbates  cancer
modeled by DeltaUAS.cDa, ctRNAi.cGa.UAS
(Zhai et al., 2012)
Pi3K92EHMC05152
ameliorates  prostate cancer
modeled by Ras85DV12.UAS
(Rambur et al., 2020)
ameliorates  carcinoma
modeled by ykiHMS00041
(Bhattacharya et al., 2024)
Pi3K92EUAS.cUa
exacerbates  high grade glioma
modeled by btl::Egfrλ.UAS
(Witte et al., 2009)
model of  high grade glioma
is exacerbated by btl::Egfrλ.UAS
(Witte et al., 2009)
exacerbates  cancer
modeled by MycUAS.cZa, p53RNAi.UAS.RasG12D
(Diaz et al., 2024)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
14 of 14
PHOSPHATIDYLINOSITOL 3-KINASE, CATALYTIC, DELTA; PIK3CD
 
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
12 of 14
PHOSPHATIDYLINOSITOL 3-KINASE, CATALYTIC, BETA; PIK3CB
       
      PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
      7 of 14
      171834
      PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
      7 of 14
      601232
      PIK3C2A; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
      4 of 14
      603601
        PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
        4 of 14
        602838
            PIK3C2G; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
            4 of 14
            609001
                PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3
                3 of 14
                602609
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    Interaction Browsers
                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                    Please see the Physical Interaction reports below for full details
                    protein-protein
                    Physical Interaction
                    Assay
                    References
                    Pi3K92E
                    protein kinase assay, autoradiography
                    (Weinkove et al., 1997)
                    Pi3K92E - Act5C
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - CG15784
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - CG30122
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - Droj2
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - Fib
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - Git
                    anti tag coimmunoprecipitation, peptide massfingerprinting
                    (Glatter et al., 2011)
                    Pi3K92E - Hsc70-3
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - InR
                    anti tag coimmunoprecipitation, Identification by mass spectrometry, peptide massfingerprinting
                    (Vinayagam et al., 2016, Friedman et al., 2011)
                    Pi3K92E - Ipo9
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - Iswi
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - Mec2
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - Nsun2
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - Pi3K21B
                    protein kinase assay, autoradiography, pull down, anti tag western blot, anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry, peptide massfingerprinting, anti bait coimmunoprecipitation
                    (Breitkopf et al., 2016, Vinayagam et al., 2016, Glatter et al., 2011, Orme et al., 2006, Wittwer et al., 2005, Weinkove et al., 1997)
                    Pi3K92E - Psi
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - Pvr
                    anti tag coimmunoprecipitation, Identification by mass spectrometry, peptide massfingerprinting
                    (Breitkopf et al., 2016, Vinayagam et al., 2016)
                    Pi3K92E - Pyk
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - Ras64B
                    anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography
                    (Vega-Cuesta et al., 2020)
                    Pi3K92E - Ras85D
                    pull down, western blot, two hybrid
                    (Orme et al., 2006)
                    Pi3K92E - Rm62
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpL10
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpL13A
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpL14
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpL17
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpL18
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpL19
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpL21
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpL28
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpL35A
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpL6
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpL7A
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpL8
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpL9
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpLP1
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpS11
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpS15
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpS15Aa
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpS17
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpS23
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpS26
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpS6
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpS7
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RpS9
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - Rpt4
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - RtGEF
                    anti tag coimmunoprecipitation, peptide massfingerprinting
                    (Glatter et al., 2011)
                    Pi3K92E - Syp
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - Zn72D
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - alt
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - chico
                    anti tag coimmunoprecipitation, Identification by mass spectrometry, peptide massfingerprinting
                    (Breitkopf et al., 2016, Vinayagam et al., 2016)
                    Pi3K92E - eIF3a
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - eIF3b
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - eIF3c
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - eIF3m
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - eIF4A
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - iPLA2-VIA
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - larp
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - msn
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - ncd
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - nonA
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - rin
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - rump
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - sta
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - vig
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - vig2
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Pi3K92E - yps
                    anti tag coimmunoprecipitation, Identification by mass spectrometry
                    (Vinayagam et al., 2016)
                    Summary of Genetic Interactions
                    Interaction Browsers
                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Pi3K92E
                    suppressible
                    Akt
                    (Gass et al., 2022, Radimerski et al., 2002, Scanga et al., 2000)
                    Pi3K92E|foxo
                    suppressible
                    Akt
                    (Goberdhan et al., 2005)
                    Pi3K92E
                    enhanceable
                    Akt
                    (Radimerski et al., 2002)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Akt
                    (Read et al., 2009)
                    Pi3K92E
                    suppressible
                    ap
                    (Coelho et al., 2005)
                    Pi3K92E|btl::Egfr
                    suppressible
                    arm|fz
                    (Portela et al., 2019)
                    Pi3K92E|btl::Egfr
                    suppressible
                    arm|wg
                    (Portela et al., 2019)
                    Pi3K92E
                    suppressible
                    aru
                    (Eddison et al., 2011)
                    Pi3K92E|btl::Egfr
                    suppressible
                    bsk
                    (Portela et al., 2019)
                    Pi3K92E
                    suppressible
                    btl::Egfr
                    (Witte et al., 2009)
                    Pi3K92E
                    enhanceable
                    btl::Egfr
                    (Witte et al., 2009)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Cdc42
                    (Chen et al., 2019)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Cdk4
                    (Read et al., 2009)
                    Pi3K92E
                    suppressible
                    Cds
                    (Liu et al., 2014)
                    Pi3K92E
                    enhanceable
                    chico
                    (Coelho et al., 2005)
                    Pi3K92E
                    suppressible
                    Chro
                    (Li et al., 2017)
                    Pi3K92E|btl::Egfr
                    suppressible
                    dap
                    (Read et al., 2009)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Drak
                    (Chen et al., 2019)
                    Pi3K92E
                    enhanceable
                    Dronc
                    (Berry and Baehrecke, 2007)
                    Pi3K92E
                    enhanceable
                    E-2c
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    E-2fa
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    E-2fb
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    E-3c1
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    E-3c4
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    E-3c7
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    ebi
                    (Marygold et al., 2011, Coelho et al., 2005)
                    Pi3K92E|btl::Egfr
                    suppressible
                    egr
                    (Portela et al., 2019)
                    Pi3K92E|btl::Egfr
                    suppressible
                    eIF4E1
                    (Read et al., 2009)
                    Pi3K92E
                    suppressible
                    FarO
                    (Cinnamon et al., 2016)
                    Pi3K92E
                    suppressible
                    foxo
                    (Slack et al., 2011, Colombani et al., 2005, Junger et al., 2003)
                    Pi3K92E|btl::Egfr
                    suppressible
                    foxo
                    (Read et al., 2009)
                    Pi3K92E|btl::Egfr
                    suppressible
                    fz
                    (Portela et al., 2019)
                    Pi3K92E|btl::Egfr
                    suppressible
                    grnd
                    (Portela et al., 2019)
                    Pi3K92E
                    suppressible
                    HDAC3
                    (Lv et al., 2012)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Hex-A
                    (Li et al., 2020)
                    Pi3K92E
                    enhanceable
                    His4
                    (Lv et al., 2012)
                    Pi3K92E
                    enhanceable
                    hppy
                    (Resnik-Docampo and de Celis, 2011)
                    Pi3K92E|btl::Egfr
                    suppressible
                    igl
                    (Portela et al., 2019)
                    Pi3K92E|btl::Egfr
                    suppressible
                    ImpL2
                    (Jarabo et al., 2021)
                    Pi3K92E
                    enhanceable
                    InR
                    (Coelho et al., 2005)
                    Pi3K92E|btl::Egfr
                    suppressible
                    L2HGDH
                    (Li et al., 2020)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Ldh
                    (Li et al., 2020)
                    Pi3K92E
                    enhanceable
                    lep
                    (Coelho et al., 2005)
                    Pi3K92E
                    suppressible
                    lilli
                    (Tang et al., 2001)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Max
                    (Read et al., 2009)
                    Pi3K92E|btl::Egfr
                    suppressible
                    mir-8
                    (Jarabo et al., 2021)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Mmp1
                    (Portela et al., 2019)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Mmp2
                    (Portela et al., 2019)
                    Pi3K92E
                    suppressible
                    mTor
                    (Gass et al., 2022, Berry and Baehrecke, 2007)
                    Pi3K92E|btl::Egfr
                    suppressible
                    mTor
                    (Read et al., 2009)
                    Pi3K92E
                    enhanceable
                    mTor
                    (Coelho et al., 2005)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Myc
                    (Li et al., 2020, Read et al., 2009)
                    Pi3K92E
                    enhanceable
                    ncm
                    (Coelho et al., 2005)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Nrg
                    (Portela et al., 2019)
                    Pi3K92E
                    enhanceable
                    Pdk1
                    (Cho et al., 2001)
                    Pi3K92E
                    suppressible
                    Pdk1
                    (Cho et al., 2001)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Pfk
                    (Li et al., 2020)
                    Pi3K92E
                    enhanceable
                    pix
                    (Coelho et al., 2005, Coelho et al., 2005)
                    Pi3K92E|btl::Egfr
                    suppressible
                    pnt
                    (Read et al., 2009)
                    Pi3K92E
                    enhanceable
                    Prp8
                    (Coelho et al., 2005)
                    Pi3K92E
                    suppressible
                    Pss
                    (Yang et al., 2019)
                    Pi3K92E
                    suppressible
                    Pten
                    (Goberdhan et al., 1999)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Pten
                    (Read et al., 2009)
                    Pi3K92E|Arf1
                    suppressible
                    Pten
                    (Khadilkar et al., 2014)
                    Pi3K92E
                    enhanceable
                    Pten
                    (Gao et al., 2000)
                    Pi3K92E
                    enhanceable
                    Ptp61F
                    (Tchankouo-Nguetcheu et al., 2014)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Rac1
                    (Chen et al., 2019)
                    Pi3K92E|btl::Egfr
                    suppressible
                    raptor
                    (Read et al., 2009)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Ras85D
                    (Read et al., 2009)
                    Pi3K92E
                    enhanceable
                    Ras85D
                    (Vega-Cuesta et al., 2020)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Rbf
                    (Read et al., 2009)
                    btl::Egfr|Pi3K92E
                    enhanceable
                    Rbf
                    (Read et al., 2009)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Rheb
                    (Jarabo et al., 2021)
                    Pi3K92E
                    suppressible
                    Rheb
                    (Saucedo et al., 2003)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Rho1
                    (Chen et al., 2019)
                    Pi3K92E
                    suppressible
                    rictor
                    (Hietakangas and Cohen, 2007)
                    Pi3K92E|btl::Egfr
                    suppressible
                    RIOK1
                    (Read et al., 2013)
                    Pi3K92E
                    suppressible
                    RIOK1
                    (Read et al., 2013)
                    Pi3K92E
                    suppressible
                    RIOK2
                    (Read et al., 2013)
                    Pi3K92E|btl::Egfr
                    suppressible
                    RIOK2
                    (Read et al., 2013)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Rok
                    (Chen et al., 2019)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Rop
                    (Chen et al., 2019)
                    Pi3K92E
                    enhanceable
                    RpL5
                    (Coelho et al., 2005)
                    Pi3K92E
                    suppressible
                    RpL8
                    (Xu et al., 2008)
                    Pi3K92E
                    enhanceable
                    RpL38
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    RpLP1
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    RpS3
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    RpS3A
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    RpS5a
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    RpS13
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    RpS17
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    RpS21
                    (Coelho et al., 2005)
                    Pi3K92E
                    enhanceable
                    RpS26
                    (Coelho et al., 2005)
                    Pi3K92E|btl::Egfr
                    suppressible
                    S6k
                    (Read et al., 2009)
                    Pi3K92E|btl::Egfr
                    suppressible
                    scra
                    (Chen et al., 2019)
                    Pi3K92E
                    enhanceable
                    Sesn
                    (Lee et al., 2010)
                    Pi3K92E
                    suppressible
                    Sesn
                    (Lee et al., 2010)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Sin1
                    (Read et al., 2009)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Sln
                    (Li et al., 2020)
                    Pi3K92E|btl::Egfr
                    suppressible
                    sqh
                    (Chen et al., 2019)
                    Pi3K92E
                    suppressible
                    srl
                    (Tiefenböck et al., 2010)
                    Pi3K92E|btl::Egfr
                    enhanceable
                    stg
                    (Read et al., 2009)
                    Pi3K92E|btl::Egfr
                    suppressible
                    stg
                    (Read et al., 2009)
                    Pi3K92E|btl::Egfr
                    suppressible
                    Thor
                    (Read et al., 2009)
                    Pi3K92E
                    suppressible
                    Tl
                    (Roth et al., 2018)
                    Pi3K92E
                    suppressible
                    Trpm
                    (Georgiev et al., 2010)
                    btl::Egfr|Pi3K92E
                    enhanceable
                    Tsc1
                    (Read et al., 2009)
                    Pi3K92E
                    suppressible
                    Wdr62
                    (Shohayeb et al., 2020)
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Arf1
                    suppressible
                    Pi3K92E
                    (Khadilkar et al., 2014)
                    Atg9
                    suppressible
                    Pi3K92E
                    (Wen et al., 2017)
                    btl::Egfr
                    enhanceable
                    Pi3K92E
                    (Witte et al., 2009)
                    btl::Egfr
                    suppressible
                    Pi3K92E
                    (Witte et al., 2009)
                    CaMKII
                    suppressible
                    Pi3K92E
                    (Chun-Jen Lin et al., 2011)
                    Cds
                    suppressible
                    Pi3K92E
                    (Liu et al., 2014)
                    chico
                    enhanceable
                    Pi3K92E
                    (Bohni et al., 1999)
                    Cul1
                    suppressible
                    Pi3K92E
                    (Wong et al., 2013)
                    CycE
                    suppressible
                    Pi3K92E
                    (Lin et al., 2011)
                    Dcp-1
                    enhanceable
                    Pi3K92E
                    (Kim et al., 2010)
                    Delta|ct
                    suppressible
                    Pi3K92E
                    (Zhai et al., 2012)
                    DJ-1α
                    suppressible
                    Pi3K92E
                    (Yang et al., 2005)
                    DJ-1α
                    enhanceable
                    Pi3K92E
                    (Yang et al., 2005)
                    egh
                    suppressible
                    Pi3K92E
                    (Dahlgaard et al., 2012)
                    foxo
                    suppressible
                    Pi3K92E
                    (Kramer et al., 2003)
                    foxo
                    enhanceable
                    Pi3K92E
                    (Goberdhan et al., 2005, Junger et al., 2003, Kramer et al., 2003)
                    hppy
                    enhanceable
                    Pi3K92E
                    (Resnik-Docampo and de Celis, 2011)
                    InR
                    suppressible
                    Pi3K92E
                    (Azuma et al., 2021)
                    Itpr
                    suppressible
                    Pi3K92E
                    (Subramanian et al., 2013)
                    Mical
                    enhanceable
                    Pi3K92E
                    (Wong et al., 2013)
                    mir-137
                    suppressible
                    Pi3K92E
                    (Saedi et al., 2024)
                    mir-278
                    suppressible
                    Pi3K92E
                    (Teleman and Cohen, 2006)
                    mir-305
                    suppressible
                    Pi3K92E
                    (Foronda et al., 2014)
                    mir-ban
                    suppressible
                    Pi3K92E
                    (Raisin et al., 2003)
                    mTor
                    enhanceable
                    Pi3K92E
                    (Hennig and Neufeld, 2002)
                    p53
                    enhanceable
                    Pi3K92E
                    (Lee et al., 2003)
                    Pi3K21B
                    suppressible
                    Pi3K92E
                    (Ejeskär et al., 2015)
                    Pss
                    suppressible
                    Pi3K92E
                    (Yang et al., 2019)
                    Pten
                    suppressible
                    Pi3K92E
                    (Malin et al., 2024, Yuen et al., 2021, Sun et al., 2020, Gao et al., 2000, Goberdhan et al., 1999, Huang et al., 1999)
                    Pten
                    enhanceable
                    Pi3K92E
                    (Gao et al., 2000, Huang et al., 1999)
                    Pvr
                    suppressible
                    Pi3K92E
                    (Bruckner et al., 2004)
                    Ras85D
                    suppressible
                    Pi3K92E
                    (Willecke et al., 2011)
                    Ras85D|dlg1
                    suppressible
                    Pi3K92E
                    (Katheder et al., 2017, Willecke et al., 2011)
                    Ras85D|rl
                    suppressible
                    Pi3K92E
                    (Murcia et al., 2019)
                    SerT
                    suppressible
                    Pi3K92E
                    (Pham et al., 2020)
                    sl
                    suppressible
                    Pi3K92E
                    (Murillo-Maldonado et al., 2011)
                    sl
                    enhanceable
                    Pi3K92E
                    (Murillo-Maldonado et al., 2011)
                    spidey
                    suppressible
                    Pi3K92E
                    (Cinnamon et al., 2016)
                    Uch
                    suppressible
                    Pi3K92E
                    (Lee et al., 2024)
                    wake
                    suppressible
                    Pi3K92E
                    (Chen et al., 2022)
                    External Data
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    MIST (genetic) - An integrated Molecular Interaction Database
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    FlyBase
                    External Links
                    FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                    KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                    Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                    External Data
                    Class of Gene
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    3R
                    Recombination map
                    3-69
                    Cytogenetic map
                    92F3-92F3
                    Sequence location
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    92F3-92F3
                    Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    92E12-92E13
                    (Leevers, 1996.10.25)
                    92E12-92E13
                    (determined by in situ hybridisation)
                    (Leevers, 1996.12.5, Leevers et al., 1996)
                    92D-92D
                    (determined by in situ hybridisation)
                    (MacDougall et al., 1995)
                    92D1-92D4
                    (determined by in situ hybridisation)
                    (MacDougall and Leevers, 1995.10.6)
                    92E-92E
                    (Maier et al., 1992)
                    Experimentally Determined Recombination Data
                    Location

                    3-69

                    (FlyBase, 2016)

                    3-72.8

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (30)
                    Genomic Clones (21)
                    cDNA Clones (107)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      Antibody Information
                      Laboratory Generated Antibodies
                       

                      polyclonal

                      (Leevers et al., 1996)
                      Commercially Available Antibodies
                       
                      Cell Line Information
                      Publicly Available Cell Lines
                       
                        Other Stable Cell Lines
                         
                          Other Comments

                          Reduced postsynaptic Pi3K92E signaling results in reduced synapse size and increased quantal content without affecting quantal size.

                          (Mozer and Sandstrom, 2012)

                          The activation of Pi3K92E by mGluRA is mediated by CaMKII and Fak56D.

                          (Chun-Jen Lin et al., 2011)

                          High levels of Pi3K92E signaling promote tumour growth while low levels suppress tumour growth.

                          (Willecke et al., 2011)

                          Signaling through Tor and its upstream regulators Pi3K92E/Pi3K21B and Rheb is necessary and sufficient to suppress starvation-induced autophagy in the fat body.

                          (Scott et al., 2004)

                          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                          (Kiger et al., 2003)

                          RNAi experiments show that dsRNA targetted at this gene suppresses the Pten-dsRNA-induced cell shape changes in Kc167 cells.

                          (Kiger et al., 2003)

                          Pi3K92E is autonomously required for imaginal disc cells to achieve their normal adult size, regulating cells size throughout the cell cycle. Pi3K92E normally promotes cell division and/or cell survival.

                          (Weinkove et al., 1999)

                          The Pi3K92E/Pi3K21B complex possesses lipid kinase activity.

                          (Leevers et al., 1996)

                          Molecular and functional analysis of Pi3K92E implies a role for Pi3K92E in growth control during development.

                          (Leevers et al., 1996)

                          Identified by PCR using degenerate primers based on regions of strong amino acid homology found within the putative lipid kinase domain of mammalian p110α and yeast Vps34p.

                          (MacDougall et al., 1995)

                          Maps within 10kb of the H gene.

                          (Maier et al., 1992)

                          Identified as a transcription unit during molecular analysis of H.

                          (Maier et al., 1992)
                          Relationship to Other Genes
                          Source for database merge of

                          Source for merge of: Pi3K92E anon-92Ed

                          (Weinkove et al., 1999)
                          Additional comments
                          Nomenclature History
                          Source for database identify of

                          Source for identity of: Pi3K92E CG4141

                          (Gong, 1999.11)
                          Nomenclature comments
                          Etymology
                          Synonyms and Secondary IDs (65)
                          Reported As
                          Symbol Synonym
                          CG4141
                          (Trivedi et al., 2020, Dey et al., 2017, Balakrishnan et al., 2015, Hosono et al., 2015, Schertel et al., 2013, Bridon et al., 2012, Glatter et al., 2011, Ni et al., 2011.7.19, Sun et al., 2010, Abe et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Qin et al., 2008, Morrison et al., 2000)
                          DP110
                          (Biglou et al., 2021, Shahzad et al., 2021, Yuan et al., 2020, Jouette et al., 2017, Monyak et al., 2017, Willecke et al., 2011)
                          Dmp110
                          (Leevers et al., 1995)
                          Dp110
                          (Gautam et al., 2025, Mudjahid et al., 2025, Zhang et al., 2025, Diaz et al., 2024, Nguyen and Cheng, 2024, Bakopoulos et al., 2023, Clemente and Weavers, 2023, Gui et al., 2023, Parisi et al., 2023, Sun et al., 2023, Wang et al., 2023, Miao et al., 2022, Azuma et al., 2021, Harrison et al., 2021, Yuen et al., 2021, Álvarez-Rendón and Riesgo-Escovar, 2020, Flatt, 2020, Li et al., 2020, Vega-Cuesta et al., 2020, Hansen et al., 2019, Wang et al., 2019, Ahmad et al., 2018, Alpar et al., 2018, Benhra et al., 2018, Kim et al., 2018, Poon et al., 2018, Roth et al., 2018, Das and Arur, 2017, Jordán-Álvarez et al., 2017, Liao et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Romero-Pozuelo et al., 2017, Xiang et al., 2017, Yun et al., 2017, Zheng et al., 2017, Agnihotri et al., 2016, Amoyel et al., 2016, Cinnamon et al., 2016, Hemalatha et al., 2016, Kučerová et al., 2016, Ejeskär et al., 2015, Mitchell et al., 2015, Panneton et al., 2015, Parker and Struhl, 2015, Schmitt et al., 2015, Avet-Rochex et al., 2014, Banreti et al., 2014, Liu et al., 2014, Radermacher et al., 2014, Hahn et al., 2013, Levayer and Moreno, 2013, Shim et al., 2013, Sim and Denlinger, 2013, Subramanian et al., 2013, Avet-Rochex et al., 2012, Dahlgaard et al., 2012, Denton et al., 2012, Pallares-Cartes et al., 2012, Karpac et al., 2011, Lin et al., 2011, Murillo-Maldonado et al., 2011, Murillo-Maldonado et al., 2011, Partridge et al., 2011, Resnik-Docampo and de Celis, 2011, Slack et al., 2011, Zhang et al., 2011, Biteau et al., 2010, McLeod et al., 2010, Siegrist et al., 2010, Slack et al., 2010, Tiefenböck et al., 2010, Diangelo et al., 2009, Jiang and Edgar, 2009, Jones et al., 2009, Kent et al., 2009, Mirth et al., 2009, Werz et al., 2009, Wu et al., 2009, Jones and Grotewiel, 2008, Learte et al., 2008, Leevers, 2008.10.20, McNeill et al., 2008, Xu et al., 2008, Berry and Baehrecke, 2007, Hall et al., 2007, Hietakangas and Cohen, 2007, Senoo-Matsuda and . Johnston, 2007, Wells and Johnston, 2007, Anonymous, 2006, Betschinger et al., 2006, DiAngelo and Birnbaum, 2006, Fuss et al., 2006, Herranz et al., 2006, Liu and Lehmann, 2006, Orme et al., 2006, Patel and Tamanoi, 2006, Vereshchagina and Wilson, 2006, Walker et al., 2006, Williams et al., 2006, Wood et al., 2006, Coelho et al., 2005, Goberdhan et al., 2005, Lievens et al., 2005, Mikeladze-Dvali et al., 2005, Mirth et al., 2005, Mirth et al., 2005, Orme and Leevers, 2005, Partridge et al., 2005, Sustar and Schubiger, 2005, Teleman et al., 2005, Wu et al., 2005, Bateman and McNeill, 2004, MacDougall et al., 2004, Papadopoulou et al., 2004, Reiling and Hafen, 2004, Resino and Garcia-Bellido, 2004, Rusten et al., 2004, de la Cova and Johnston, 2003, Junger et al., 2003, Miron et al., 2003, Raisin et al., 2003, Saucedo et al., 2003, Williams et al., 2003, Yang and Baker, 2003, Aigaki et al., 2002, Britton et al., 2002, Claeys et al., 2002, Hennig and Neufeld, 2002, Hipfner et al., 2002, Prober and Edgar, 2002, Radimerski et al., 2002, Towers and Sattelle, 2002, Xue and Noll, 2002, Cho et al., 2001, Clancy et al., 2001, Coelho et al., 2001, Gems and Partridge, 2001, Halfar et al., 2001, Miron et al., 2001, Radimerski et al., 2001, Rintelen et al., 2001, Strauss, 2001, Tang et al., 2001, Britton and Edgar, 2000, Coelho and Leevers, 2000, Raabe, 2000, Scanga et al., 2000, Teleman and Cohen, 2000, Weinkove and Leevers, 2000, Bohni et al., 1999, Coelho and Leevers, 1999, Goberdhan et al., 1999, Leevers, 1999, Leevers et al., 1999, Moghal and Sternberg, 1999, Weinkove et al., 1999, Leevers et al., 1998, Riesgo-Escovar et al., 1998, Rommel and Hafen, 1998, Wymann and Pirola, 1998, Leevers et al., 1997, Vanhaesebroeck et al., 1997, Weinkove et al., 1997, Weinkove et al., 1997, Leevers, 1996.12.5, Leevers et al., 1996)
                          Dp110/PI3K
                          (Stocker et al., 2004)
                          Dpp110
                          (Walker et al., 2011)
                          PI(3)K
                          (Fuss et al., 2007, Orme et al., 2006, Rintelen et al., 2001, Edgar, 1999, Lehner, 1999)
                          PI-3 kinase
                          (Read and Thomas, 2008)
                          PI-3-K
                          (Davies, 2002)
                          PI3'K
                          (Scanga et al., 2000)
                          PI3K
                          (Andreatta et al., 2025, Chen et al., 2024, Lee et al., 2024, Sanz et al., 2023, Chen et al., 2022, Du et al., 2022, Gass et al., 2022, Jarabo et al., 2022, Jarabo et al., 2022, Molina et al., 2022, Wang et al., 2022, Wenner and Pekala, 2022, Yuh Chew et al., 2022, Zhao et al., 2022, Atilano et al., 2021, Gautam et al., 2021, Han et al., 2021, Kannangara et al., 2021, Lam Wong and Verheyen, 2021, Morin-Poulard et al., 2021, Oliveira et al., 2021, Sciambra and Chtarbanova, 2021, Coelho, 2020, Ding et al., 2020, Ho and Treisman, 2020, Jasper, 2020, Jossin, 2020, Luo et al., 2020, Mariano et al., 2020, Otsuki and Brand, 2020, Pan et al., 2020, Pastor-Pareja, 2020, Shohayeb et al., 2020, Texada et al., 2020, Trivedi et al., 2020, Borreguero-Muñoz et al., 2019, Boulan et al., 2019, Hansen et al., 2019, Kim and Choi, 2019, Portela et al., 2019, Su et al., 2019, Toshniwal et al., 2019, Yang et al., 2019, Lee et al., 2018, Arnés et al., 2017, Gupta and Ray, 2017, Kim et al., 2017, Li et al., 2017, Paglia et al., 2017, Wen et al., 2017, Yun et al., 2017, Zheng et al., 2017, Agnihotri et al., 2016, Jia et al., 2015, Okamoto and Nishimura, 2015, Ugrankar et al., 2015, Homem et al., 2014, Khadilkar et al., 2014, Radermacher et al., 2014, Ibar et al., 2013, Luo et al., 2013, Nässel et al., 2013, Nirala et al., 2013, Pickering et al., 2013, Subramanian et al., 2013, Tixier et al., 2013, Wong et al., 2013, Acebes et al., 2012, Choi and Hyun, 2012, Jordán-Álvarez et al., 2012, Lv et al., 2012, Morris et al., 2012, Mozer and Sandstrom, 2012, Murray et al., 2012, Chun-Jen Lin et al., 2011, Kamakura, 2011, Zhang et al., 2011, Aron et al., 2010, Chell and Brand, 2010, Delanoue et al., 2010, Georgiev et al., 2010, Kockel et al., 2010, Kremer et al., 2010, Lee et al., 2010, Li et al., 2010, Liu et al., 2010, Tiefenböck et al., 2010, Zeng et al., 2010, Cliffe et al., 2009, Hyun et al., 2009, Jiang and Edgar, 2009, Ninov et al., 2009, Werz et al., 2009, Wu et al., 2009, Honegger et al., 2008, Howlett et al., 2008, Wang et al., 2008, Ahrens et al., 2007, Hall et al., 2007, Hoshizaki and Gibbs, 2007, Howlett et al., 2007, Jovceva et al., 2007, Lasko and Sonenberg, 2007, Lavery and Stern, 2007, Lavery et al., 2007, Caldwell et al., 2006, Lavery and Stern, 2006, Liu and Lehmann, 2006, Luo et al., 2006, Martin-Pena et al., 2006, Martin-Pena et al., 2006, Shiojima and Walsh, 2006, Wood et al., 2006, Caldwell et al., 2005, King-Jones and Thummel, 2005, McNeill and Bateman, 2005, Grewal and Saucedo, 2004, Leopold, 2004, Marygold et al., 2004, Scott et al., 2004, Scott et al., 2004, Bergmann and Lane, 2003, Dickson, 2003, Gumienny and Padgett, 2003, Heriche et al., 2003, Li et al., 2003, Longo and Finch, 2003, Luque et al., 2003, Neufeld, 2003, Nijhout, 2003, Saucedo et al., 2003, Stocker et al., 2003, Aigaki et al., 2002, Saucedo and Edgar, 2002, Gingras et al., 2001, Gupta and Schupbach, 2001, Halfar et al., 2001, Jünger et al., 2001, Tapon et al., 2001, Bohni et al., 1999, Keyes et al., 1999, Leevers, 1999, Spana and Perrimon, 1999, Stambolic et al., 1999)
                          PI3K dp110
                          (Jarabo et al., 2022)
                          PI3K-92D
                          (MacDougall and Leevers, 1995.10.6, MacDougall et al., 1995)
                          PI3K-92E/Dp110
                          (MacDougall et al., 1998)
                          PI3K-Dp110
                          (Cortina-Andrada et al., 2007)
                          PI3K-I
                          (O'Farrell et al., 2013)
                          PI3K-cat
                          (Tamada et al., 2021)
                          PI3K-dp110
                          (Noebels et al., 2012, Saunders et al., 2003)
                          PI3K92E
                          (Qin et al., 2025, Sanal et al., 2023, de Tredern et al., 2021, Jans et al., 2021, Keith et al., 2021, Luo et al., 2020, Sun et al., 2020, Muñoz-Soriano et al., 2018, Tang et al., 2018, Jouette et al., 2017, Balakrishnan et al., 2015, Bothe et al., 2014, Tchankouo-Nguetcheu et al., 2014, Jagut et al., 2013, Khuong et al., 2013, Nowak et al., 2013, Pickering et al., 2013, Tixier et al., 2013, Wang et al., 2013, Bridon et al., 2012, Zhai et al., 2012, Acebes et al., 2011, Eddison et al., 2011, Slack et al., 2010, Martin et al., 2007, Herranz et al., 2006)
                          PI3K93E
                          (Toshniwal et al., 2025)
                          PI3k
                          (Nässel et al., 2013, Parrish et al., 2009)
                          PI3K
                          (Hardie, 2003)
                          Pi3K
                          (Fischer et al., 2025, Wang et al., 2024, Cui et al., 2020, Malita and Rewitz, 2020, Chi et al., 2019, Murcia et al., 2019, Di Cara and King-Jones, 2016, Kwon et al., 2015, Dimitroff et al., 2012, Tang et al., 2011, Li et al., 2010, Nuzhdin et al., 2009, Edgar, 2006, Papadopoulou et al., 2004)
                          Pi3K92D
                          (Arnés et al., 2020)
                          Pi3K92E
                          (Klimkowski Arango and Morgante, 2025, Simmons et al., 2025, Wāng, 2025, Collins et al., 2024, Fangninou et al., 2024, Meyer et al., 2024, Reimels et al., 2024, Wang et al., 2024, Gui et al., 2023, Liu et al., 2023, Xia et al., 2023, Jiang et al., 2022, Lu et al., 2022, Bilder et al., 2021, Fabian et al., 2021, Formica et al., 2021, Heier et al., 2021, Kim and O'Connor, 2021, Lebo et al., 2021, Millington et al., 2021, Ostalé et al., 2021, Ghosh et al., 2020, Li et al., 2020, Qin et al., 2020, Fahey-Lozano et al., 2019, Lattner et al., 2019, Li et al., 2019, Moreno et al., 2019, Mouawad et al., 2019, Terrasi et al., 2019, Hauswirth et al., 2018, Im et al., 2018, Sharma et al., 2018, Sollazzo et al., 2018, Dey et al., 2017, Park et al., 2017, Transgenic RNAi Project members, 2017-, Xiang et al., 2017, Purice et al., 2016, Vinayagam et al., 2016, Aradska et al., 2015, Grotewiel and Bettinger, 2015, Li et al., 2015, Lin et al., 2015, Park et al., 2015, Ugrankar et al., 2015, Xia et al., 2015, Das et al., 2014, Schertel et al., 2013, Sopko and Perrimon, 2013, Alvarez-Ponce et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Korenjak et al., 2012, Tokusumi et al., 2012, Friedman et al., 2011, Zhang et al., 2011, Sun et al., 2010, Velichkova et al., 2010, Alvarez-Ponce et al., 2009, Jiang and Edgar, 2009, Kent et al., 2009, Witte et al., 2009, Branco et al., 2008, Liu and Lehmann, 2008, Qin et al., 2008, Chintapalli et al., 2007, Jordan et al., 2005)
                          Pi3Kp110
                          (Oldham et al., 2002)
                          Pi3k
                          (Wu et al., 2021, Rambur et al., 2020, Kim et al., 2010)
                          Pi3k92E
                          (Zeng et al., 2020)
                          Pi3k92e
                          (Breitkopf et al., 2016)
                          Pi3ks
                          (Pandey et al., 2018)
                          PiK92E
                          (Mouawad et al., 2019, Pezzulo et al., 2012)
                          anon-92Ed
                          dP110
                          (Wittwer et al., 2005)
                          dP13K
                          (Kamakura, 2011)
                          dPI3K
                          (Pospisilik et al., 2010, Oldham et al., 2005, Jorgensen and Tyers, 2004, Kim et al., 2004, Jacinto and Hall, 2003, Manning and Cantley, 2003, Miron et al., 2003, Oldham and Hafen, 2003)
                          dPI3K92E
                          (Branco et al., 2008)
                          dp110
                          (Castello-Pons et al., 2025, Saez-Carrion et al., 2024, Bertrand et al., 2023, Antonica et al., 2022, Courant et al., 2022, Jarabo et al., 2022, Jiang et al., 2022, Losada-Pérez et al., 2022, Saborio et al., 2022, Sood et al., 2022, Weina et al., 2022, Yamaguchi et al., 2022, Cheng et al., 2021, Conte et al., 2021, Maravat et al., 2021, Vigneswaran et al., 2021, Ariss et al., 2020, Barretto et al., 2020, Portela et al., 2020, Borreguero-Muñoz et al., 2019, Chen and Read, 2019, Chen et al., 2019, Chi et al., 2019, Portela et al., 2019, Santabárbara-Ruiz et al., 2019, Ghiglione et al., 2018, Otsuki and Brand, 2018, Read, 2018, Katheder et al., 2017, Park et al., 2017, Sipe and Siegrist, 2017, Parker and Struhl, 2015, Claret et al., 2014, Claret et al., 2014, Bader et al., 2013, Buszard et al., 2013, Jagut et al., 2013, Read et al., 2013, Sarraf-Zadeh et al., 2013, Murray et al., 2012, Glatter et al., 2011, Read, 2011, Chell and Brand, 2010, Froldi et al., 2010, Li et al., 2010, Ninov et al., 2009, Read et al., 2009, Porstmann et al., 2008, Hall et al., 2007, Senoo-Matsuda and Johnston, 2007, Teleman and Cohen, 2006, Grewal et al., 2005, Trotta et al., 2005, Kramer et al., 2003)
                          dp110α
                          (Read et al., 2013)
                          dpP110
                          (Katheder et al., 2017)
                          p110
                          (Kim et al., 2018, Grotewiel and Bettinger, 2015, Alvarez-Ponce et al., 2012, Eddison et al., 2011, Sousa-Nunes et al., 2011, Haberman et al., 2010, Abe et al., 2009, Sims et al., 2009, Wu et al., 2009, Wu and Brown, 2006, Shingleton, 2005, Bruckner et al., 2004, Bruckner et al., 2004, Pan et al., 2004, Burgering and Kops, 2002, Duchek and Rorth, 2001, Oldham et al., 2000)
                          p120
                          (Leevers et al., 1996)
                          pI3K
                          (Yu et al., 2020)
                          pi3k
                          (Levayer et al., 2015)
                          pi3k92E
                          (Hirabayashi, 2016)
                          pi3k92e
                          (Doherty et al., 2014)
                          rea
                          (Maier et al., 1992)
                          type-1 PI3K
                          (Rorth, 2002)
                          Name Synonyms
                          PI 3-kinase
                          (Hardie, 2003, Day and Lawrence, 2000)
                          PI3 kinase
                          (Slack et al., 2011, Haberman et al., 2010, Parrish et al., 2009, Lee and Orr-Weaver, 2003)
                          PI3-kinase
                          (Anonymous, 2006, Coelho et al., 2003, Wilson and Leptin, 2000)
                          PI3K
                          (Kim and Jain, 2020)
                          PI3K Class I
                          (Abe et al., 2009)
                          PI3Kinase92E
                          (Khuong et al., 2013)
                          Phosphatidylinositol 3-kinase 92E
                          Phosphatidylinositol-3-kinase
                          (Kent et al., 2009)
                          Phosphoinositide-3 Kinase
                          (Froldi et al., 2010)
                          Phosphotidylinositol 3 kinase
                          (Jiang and Edgar, 2009)
                          Pi3K92E
                          (Branco et al., 2008)
                          class I PI(3)K
                          (Orme et al., 2006)
                          dPI 3-kinase
                          (Marygold and Leevers, 2002)
                          insulin-regulated PI3 kinase
                          (Tauber et al., 2007)
                          p110 PI3 kinase
                          (Bohni et al., 1999)
                          phosphatidylinositol 3-kinase
                          (Hariharan, 2006, Papadopoulou et al., 2004)
                          phosphatidylinositol-3 kinase
                          (Kamakura, 2011)
                          phospho-inositol-3 kinase at 92E
                          (Jordan et al., 2005)
                          phosphoinositide 3 kinase Dp110
                          (Bridon et al., 2012)
                          phosphoinositide 3-kinase
                          (Lv et al., 2012, Lee et al., 2010, Werz et al., 2009, Jovceva et al., 2007, Leevers, 1996.10.25)
                          Secondary FlyBase IDs
                          • FBgn0014938
                          Datasets (1)
                          Study focus (1)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          • bait_protein
                          PPI_InR-Tor_interaction_map
                          Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.
                          Study result (0)
                          Result
                          Result Type
                          Title
                          External Crossreferences and Linkouts ( 87 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                          FlyMine - An integrated database for Drosophila genomics
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          Linkouts
                          BioGRID - A database of protein and genetic interactions.
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          Flygut - An atlas of the Drosophila adult midgut
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                          KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                          MIST (genetic) - An integrated Molecular Interaction Database
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                          References (647)