FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: colorectal cancer, multigenic
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General Information
Name
colorectal cancer, multigenic
FlyBase ID
FBhh0000658
Disease Ontology Term
Parent Disease
OMIM
Overview

This report encompasses a series of multigenic models of colorectal cancer, using combinations of Drosophila genes related to a number of human genes implicated in this disease: human NRAS or KRAS (using an activated form of Dmel\Ras85D), human TP53 (using RNAi-knockdown targeted to Dmel\p53), human APC (using RNAi-knockdown targeted to Dmel\Apc), human PIK3CA (using RNAi-knockdown targeted to Dmel\Pten, a negative regulator of the PIK3 signaling pathway), human PTEN (using RNAi-knockdown targeted to Dmel\Pten), and human SMAD4 (using RNAi-knockdown targeted to Dmel\Med). Multigenic combinations were created in the adult hindgut epithelium using GAL4 driven by the hindgut-specific byn promoter. 32 different combinations that correspond those found in colorectal human tumors have been characterized; mechanisms of drug resistance have been investigated.

A CRISPR-Cas9-based colorectal cancer model uses an ISC-specific driver to express sgRNAs targeting multiple Drosophila genes, Apc, Apc2, p53, Med and Pten, combined with expression of activated Ras85D.

See also human disease model reports for 'colorectal cancer' (FBhh0000178), 'cancer, multiple, RAS-related' (FBhh0000474), 'cancer, multiple, TP53-related' (FBhh0000340), 'cancer, multiple, PIK3C-related' (FBhh0000400), 'familial adenomatous polyposis 1' (FBhh0000135).

[updated May 2023 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: colorectal cancer, multigenic
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics

Genes recurrently mutated in colon tumors lead to misregulation of five distinct signalling pathways: Wnt, receptor tyrosine kinase/Ras, p53, transforming growth factor-b and PI3K (FBrf0234055).

(FlyBase Curators, 2013-)

See MIM:114500.

(FlyBase Curators, 2013-)
Cellular phenotype and pathology
Molecular information
External links
Disease synonyms
colon cancer
CRC
Ortholog Information
Human gene(s) in FlyBase
    Human gene (HGNC)
    Symbol / Name
    SMAD4; SMAD family member 4
    D. melanogaster ortholog (based on DIOPT)
    Dmel\Med
    (DIOPT, 2013-)
    Comments on ortholog(s)

    One to one: 1 human to 1 Drosophila.

    Human gene (HGNC)
    Symbol / Name
    NRAS; NRAS proto-oncogene, GTPase
    D. melanogaster ortholog (based on DIOPT)
    Dmel\Ras85D
    (DIOPT, 2013-)
    Comments on ortholog(s)

    Many to many: multiple paralogs and orthologs in both species.

    Human gene (HGNC)
    Symbol / Name
    KRAS; KRAS proto-oncogene, GTPase
    D. melanogaster ortholog (based on DIOPT)
    Dmel\Ras85D
    (DIOPT, 2013-)
    Comments on ortholog(s)

    Many to many: multiple paralogs and orthologs in both species.

    Human gene (HGNC)
    Symbol / Name
    TP53; tumor protein p53
    D. melanogaster ortholog (based on DIOPT)
    Dmel\p53
    (DIOPT, 2013-)
    Comments on ortholog(s)

    Many to one: 3 human to 1 Drosophila; additional orthologous human genes are TP63 and TP73.

    Human gene (HGNC)
    Symbol / Name
    APC; APC regulator of Wnt signaling pathway
    D. melanogaster ortholog (based on DIOPT)
    Dmel\Apc
    (DIOPT, 2013-)
    Dmel\Apc2
    (DIOPT, 2013-)
    Comments on ortholog(s)

    Many to many: 2 human to 2 Drosophila. There are two orthologous genes in each species, APC and APC2 in humans, Apc and Apc2 in flies.

    Human gene (HGNC)
    Symbol / Name
    PTEN; phosphatase and tensin homolog
    D. melanogaster ortholog (based on DIOPT)
    Dmel\Pten
    (DIOPT, 2013-)
    Comments on ortholog(s)

    One to one: 1 human to 1 Drosophila.

    Human gene (HGNC)
    Symbol / Name
    PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
    D. melanogaster ortholog (based on DIOPT)
    Dmel\Pi3K92E
    (DIOPT, 2013-)
    Comments on ortholog(s)

    Many to one (4 human to one Drosophila); the 4 human genes are PIK3CD, PIK3CB, PIK3CG, and PIK3CA.

    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (5)
      Dmel\Ras85D
      Gene Snapshot
      Ras oncogene at 85D (Ras85D) encodes a protein that acts downstream of several cell signals, most notably from Receptor Tyrosine Kinases, to regulate tissue growth and development. When abnormally activated it can direct developmental defects and tissue hyperplasia, mimicking aspects of human disease including Rasopathies and cancer, respectively. [Date last reviewed: 2019-03-14]
      Molecular function (GO)
      Cellular component (GO)
      Gene Groups / Pathways
      Comments on ortholog(s)

      High-scoring ortholog of human genes KRAS, HRAS, and NRAS (many to many; multiple paralogs and orthologs in both species). Dmel\Ras85D shares 78-86% identity and 86-92% similarity with KRAS, HRAS, and NRAS; for these three human genes, Ras85D is the highest-scoring ortholog in Drosophila.

      Orthologs and Alignments from DRSC
      DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
      H. sapiens (Human)
      Dmel\p53
      Gene Snapshot
      p53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair. [Date last reviewed: 2019-03-14]
      Molecular function (GO)
      Cellular component (GO)
      Gene Groups / Pathways
      Comments on ortholog(s)

      High-scoring ortholog of human genes TP53, TP63 and TP73 (1 Drosophila to many human). Dmel\p53 shares 20-24% identity and 36-41% similarity with the human genes.

      Orthologs and Alignments from DRSC
      DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
      H. sapiens (Human)
      Dmel\Apc
      Gene Snapshot
      APC-like (Apc) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary family member during CNS and eye development, and functions redundantly with the product of Apc2 in adult development. [Date last reviewed: 2019-03-07]
      Molecular function (GO)
      Cellular component (GO)
      Gene Groups / Pathways
      Comments on ortholog(s)

      Ortholog of human genes APC and APC2 (2 Drosophila to 2 human). Dmel\Apc shares 25-26% identity and 37% similarity with both human genes; it lacks a microtubule-binding domain found at the C terminus of the human APC gene.

      Orthologs and Alignments from DRSC
      DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
      H. sapiens (Human)
      Dmel\Pten
      Gene Snapshot
      Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. [Date last reviewed: 2018-10-18]
      Molecular function (GO)
      Cellular component (GO)
      Gene Groups / Pathways
      Comments on ortholog(s)

      High-scoring ortholog of human PTEN (1 Drosophila to 1 human); Dmel\Pten shares 39% identity and 55% similarity with the human gene.

      Orthologs and Alignments from DRSC
      DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
      H. sapiens (Human)
      Dmel\Med
      Gene Snapshot
      Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. [Date last reviewed: 2019-03-14]
      Molecular function (GO)
      Cellular component (GO)
      Gene Groups / Pathways
      Comments on ortholog(s)

      High-scoring ortholog of human SMAD4 (1 Drosophila to 1 human); Dmel\Med shares 50% identity and 56% similarity with the human gene.

      Orthologs and Alignments from DRSC
      DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
      H. sapiens (Human)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (241 groups)
        Ras85D
        protein-protein
        Interacting group
        Assay
        References
        Ras85D - alt
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - Arc1
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - ave
        pull down, anti tag western blot
        (Maisonneuve et al., 2024)
        Ras85D - CG31550
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - cindr
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - cno
        two hybrid, anti tag coimmunoprecipitation, autoradiography
        (Boettner and Van Aelst, 2007, Carmena et al., 2006)
        Ras85D - Droj2
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - eIF3i
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - glo
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - Gyc76C
        anti tag coimmunoprecipitation, anti tag western blot
        (Iwashita et al., 2020)
        Ras85D - lark
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - mod(mdg4)
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - Nf1
        gtpase assay, autoradiography
        (Walker et al., 2006)
        Ras85D - Nop60B
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - Pi3K92E
        pull down, western blot, two hybrid
        (Orme et al., 2006)
        Ras85D - pico
        two hybrid
        (Lyulcheva et al., 2008)
        Ras85D - Pyk
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - Raf
        anti tag coimmunoprecipitation, anti tag western blot, two hybrid, pull down
        (Yang and Terman, 2012, Ding et al., 2010, Mishra et al., 2005)
        Ras85D - rau
        pull down, anti tag western blot
        (Sieglitz et al., 2013)
        Ras85D - Rgl
        two hybrid
        (Mirey et al., 2003)
        Ras85D - RpL6
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - RpL15
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - RpL21
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - RpL23A
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - RpL24
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - RpS2
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - RpS27
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Ras85D - spri
        anti tag coimmunoprecipitation, anti tag western blot
        (Jekely et al., 2005)
        Ras85D - Sumo
        pull down, covalent binding, western blot, anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Nie et al., 2009)
        p53
        protein-protein
        Interacting group
        Assay
        References
        p53
        coimmunoprecipitation, anti tag western blot, pull down, autoradiography, anti tag coimmunoprecipitation, western blot
        (Park et al., 2019, Zhang et al., 2015, Lunardi et al., 2010)
        p53 - abd-A
        bimolecular fluorescence complementation, fluorescence microscopy
        (Bischof et al., 2018)
        p53 - Acat1
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Ada2b
        anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot
        (Pankotai et al., 2013, Kusch et al., 2003)
        p53 - AGO2
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Ahcy
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - al
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        p53 - ap
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - asf1
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - asp
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - aub
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Bap60
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - boly
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - bowl
        two hybrid array
        (Shokri et al., 2019)
        p53 - Brd8
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - bsf
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - bsk
        anti tag coimmunoprecipitation, western blot
        (Gowda et al., 2012)
        p53 - Cep89
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG1074
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG1137
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG1602
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG1647
        two hybrid array
        (Shokri et al., 2019)
        p53 - CG1958
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG3610
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG4854
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, two hybrid array
        (Shokri et al., 2019, Rhee et al., 2014)
        p53 - CG6325
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG6333
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG6686
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG7139
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG7379
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG7387
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG7634
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG8236
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG8851
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG10333
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG11035
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG12861
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG13436
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG15269
        two hybrid array
        (Shokri et al., 2019)
        p53 - CG30059
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - CG32985
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - chb
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - chinmo
        two hybrid array
        (Shokri et al., 2019)
        p53 - Coprox
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Corp
        anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, western blot
        (Chakraborty et al., 2015)
        p53 - cort
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Cp110
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - croc
        two hybrid array
        (Shokri et al., 2019)
        p53 - CycG
        two hybrid, anti tag coimmunoprecipitation, western blot
        (Bayer et al., 2017)
        p53 - Cyp6a22
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Cyp6d5
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Cyt-c1
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Daxx
        pull down, autoradiography, two hybrid
        (Lunardi et al., 2010, Bodai et al., 2007)
        p53 - Dlip3
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        p53 - Dll
        two hybrid array
        (Shokri et al., 2019)
        p53 - Dph1
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - dsx
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - dup
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - dyl
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Fdh
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - fdl
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Gas8
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Gcn5
        pull down, western blot, anti bait coimmunoprecipitation
        (Kusch et al., 2003)
        p53 - grau
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - gry
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - gus
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - hay
        anti bait coimmunoprecipitation, western blot
        (Villicaña et al., 2013)
        p53 - hmw
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Hsf
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Hsp23
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        p53 - Hsp26
        anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Lei et al., 2017, Rhee et al., 2014)
        p53 - Hsp27
        anti bait coimmunoprecipitation, western blot
        (Lei et al., 2017)
        p53 - Ice2
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Idi
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - if
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Imp
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - INPP5E
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - jp
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - ktub
        two hybrid array
        (Shokri et al., 2019)
        p53 - lost
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - lwr
        two hybrid, pull down, autoradiography
        (Hu et al., 2017.6.13, Pardi et al., 2011)
        p53 - Mmp2
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Mppa
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - mrj
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - mrn
        anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, anti bait coimmunoprecipitation, western blot
        (Villicaña et al., 2013)
        p53 - mRpL16
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - mtgo
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - mTTF
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - mu2
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - mura
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - ND-51L2
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Nna1
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Non1
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - nord
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Nprl3
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - pho
        two hybrid array, bimolecular fluorescence complementation, fluorescence microscopy
        (Shokri et al., 2019)
        p53 - PPO2
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - raskol
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - RPA1
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - RtcB
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - SA1
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Sas-6
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - sima
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - sip3
        enzymatic study, western blot
        (Yamasaki et al., 2007)
        p53 - Sirt1
        anti tag coimmunoprecipitation, western blot
        (Bauer et al., 2009)
        p53 - Sox102F
        two hybrid array
        (Shokri et al., 2019)
        p53 - spoon
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - sqh
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - ssx
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Su(var)2-10
        two hybrid, pull down, autoradiography
        (Pardi et al., 2011)
        p53 - Svil
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Taf3
        two hybrid, pull down, autoradiography
        (Bereczki et al., 2008)
        p53 - Taf11
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        p53 - tbrd-1
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Tfb1
        anti bait coimmunoprecipitation, western blot
        (Villicaña et al., 2013)
        p53 - Timmdc1
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Tm1
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Tom40
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Topors
        pull down, autoradiography
        (Secombe and Parkhurst, 2004)
        p53 - toy
        pull down, autoradiography, two hybrid array
        (Shokri et al., 2019, Lunardi et al., 2010)
        p53 - TTLL5
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - TwdlW
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Uba2
        two hybrid, pull down, autoradiography
        (Pardi et al., 2011)
        p53 - Ubc6
        pull down, western blot, coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation
        (Chen et al., 2011)
        p53 - Ubx
        bimolecular fluorescence complementation, fluorescence microscopy
        (Bischof et al., 2018)
        p53 - uno
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - Usp7
        enzymatic study, western blot
        (van der Knaap et al., 2005)
        p53 - Utx
        anti bait coimmunoprecipitation, western blot
        (Zhang et al., 2013)
        p53 - Vha36-2
        pull down, autoradiography
        (Lunardi et al., 2010)
        p53 - yki
        anti tag coimmunoprecipitation, anti tag western blot
        (Di Cara et al., 2015)
        RNA-RNA
        Interacting group
        Assay
        References
        p53 - mir-219
        fluorescence technology, luminiscence technology
        (Barrio et al., 2014)
        p53 - mir-279
        luminiscence technology
        (Barrio et al., 2014)
        p53 - mir-283
        fluorescence technology, luminiscence technology
        (Barrio et al., 2014)
        p53 - mir-305
        luminiscence technology, fluorescence technology, necessary binding region
        (Barrio et al., 2014)
        p53 - mir-1014
        luminiscence technology
        (Barrio et al., 2014)
        Apc
        protein-protein
        Interacting group
        Assay
        References
        Apc - Apc2
        two hybrid, colocalization, fluorescence microscopy, inferred by author
        (Mattie et al., 2010)
        Apc - arm
        pull down, autoradiography, coimmunoprecipitation, western blot
        (Hamada and Bienz, 2004, Hayashi et al., 1997)
        Apc - Axn
        pull down, autoradiography
        (Hamada et al., 1999)
        Apc - CtBP
        pull down, autoradiography
        (Hamada and Bienz, 2004)
        Apc - dia
        pull down, anti tag western blot
        (Jaiswal et al., 2013, Webb et al., 2009)
        Apc - Eb1
        two hybrid
        (Mattie et al., 2010)
        Apc - Kap3
        two hybrid
        (Mattie et al., 2010)
        Pten
        protein-protein
        Interacting group
        Assay
        References
        Pten - 14-3-3ζ
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Acc
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - AGO2
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - α-Spec
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - alt
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - ana2
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - AspRS-m
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Bap111
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - baz
        anti tag coimmunoprecipitation, anti tag western blot, two hybrid
        (von Stein et al., 2005)
        Pten - Brr2
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Caf1-55
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - CaMKII
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Cand1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - CCT1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - CG2691
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - CG8939
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - CG10333
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - CG13185
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - CG15099
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - CG15784
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - CG30122
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Cpsf6
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - eIF3a
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - eIF3c
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - eIF3e
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - eIF3m
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - faf
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Gnf1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Gp150
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - gw
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - HDAC1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - His3:CG31613
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - HnRNP-K
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Hsc70-3
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - HUWE1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - kst
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - larp
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - lva
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - MEP-1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - mRpL12
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - msk
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - ncd
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - ncm
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Nup98-96
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Nup107
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Nup358
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - poe
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Prp8
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - puf
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - RanGAP
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Rm62
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - RpS7
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - RpS14a
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Rpt2
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - ScsβA
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - sta
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Syp
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Tep4
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - Uggt
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Pten - wal
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Med
        protein-protein
        Interacting group
        Assay
        References
        Med - eIF4A
        anti tag coimmunoprecipitation, anti tag western blot
        (Li and Li, 2006)
        Med - fuss
        anti tag coimmunoprecipitation, anti tag western blot, two hybrid
        (Fischer et al., 2012)
        Med - hiw
        two hybrid, pull down, autoradiography
        (McCabe et al., 2004)
        Med - lwr
        two hybrid
        (Miles et al., 2008)
        Med - Mad
        anti tag coimmunoprecipitation, anti tag western blot, autoradiography, pull down, tag visualisation
        (Cheng et al., 2013, Kazemian et al., 2013, Kamiya et al., 2008, Takaesu et al., 2006, Inoue et al., 1998, Wisotzkey et al., 1998)
        Med - Ote
        anti tag coimmunoprecipitation, anti tag western blot, fluorescent resonance energy transfer, fluorescence microscopy, anti bait coimmunoprecipitation, western blot
        (Jiang et al., 2008)
        Med - Rel
        two hybrid array
        (Shokri et al., 2019)
        Med - Smox
        anti tag coimmunoprecipitation, anti tag western blot
        (Takaesu et al., 2006)
        Med - Snoo
        anti tag coimmunoprecipitation, anti tag western blot
        (Quijano et al., 2010, Takaesu et al., 2006)
        RNA-RNA
        Interacting group
        Assay
        References
        Med - mir-124
        luminiscence technology
        (Sun et al., 2012)
        Alleles Reported to Model Human Disease (Disease Ontology) (72 alleles)
        Ras85D
        Models Based on Experimental Evidence ( 17 )
        Allele
        Disease
        Evidence
        References
        Ras85DHMS01294
        model of  Noonan syndrome 3
        CEA
        (Cattaneo et al., 2020)
        Ras85DG12V.UAS
        model of  cancer
        CEA with RhoGEF2RE.UAS
        (Khoo et al., 2013)
        CEA with RokCAT.UAS
        (Khoo et al., 2013)
        CEA with sqhE20E21.UAS.cCa
        (Khoo et al., 2013)
        Ras85DG13Q.UAS
        model of  cancer
        CEA
        (Xu et al., 2023)
        CEA with PtenHMS00044, RbfHMS03004
        (Parkhitko et al., 2021)
        Ras85DN17.UAS
        model of  Noonan syndrome 3
        CEA
        (Cattaneo et al., 2020)
        Ras85DQ13.UAS
        model of  cancer
        CEA
        (Tamamouna et al., 2021)
        Ras85DV12.GMR
        model of  cancer
        CEA
        (Okada et al., 2023)
        Ras85DV12.S35.UAS
        model of  cardiomyopathy
        CEA
        (Yu et al., 2013)
        model of  carcinoma
        CEC
        (Karim and Rubin, 1998)
        Ras85DV12.UAS
        model of  carcinoma
        CEA
        (Martínez-Abarca Millán and Martín-Bermudo, 2023, Ito and Igaki, 2021, Kong et al., 2021, Rackley et al., 2021, Soler Beatty et al., 2021, Wei et al., 2021, Wu et al., 2021, Murcia et al., 2019, Zoranovic et al., 2018, Pérez et al., 2015, Igaki et al., 2006)
        CEA with dlg1GD4689
        (Santabárbara-Ruiz and Léopold, 2021)
        CEA with scrib673
        (Amcheslavsky et al., 2018, Pérez et al., 2015)
        CEC
        (Rosen et al., 2019, Karim and Rubin, 1998)
        CEC with scrib1
        (Rosen et al., 2019)
        CEA with l(2)gl4
        (Ding et al., 2022, Singh et al., 2022, Ito and Igaki, 2021, Wu et al., 2021, Mishra-Gorur et al., 2019, Zhang et al., 2019, Srivastava et al., 2007, Igaki et al., 2006)
        CEA with Lkb14A4-2
        (Rackley et al., 2021)
        CEA with scrib1
        (Kong et al., 2021, Mishra-Gorur et al., 2019, Srivastava et al., 2007, Igaki et al., 2006, Uhlirova and Bohmann, 2006)
        CEA with dlg114
        (Ito and Igaki, 2021, Igaki et al., 2006)
        CEA with shgk03401
        (Igaki et al., 2006)
        CEA with msn3208
        (Kong et al., 2021)
        CEA with snaUAS.cAa
        (Wu et al., 2021)
        CEA with scribKK101128
        (Murcia et al., 2019)
        CEA with scribHMJ21977
        (Snigdha et al., 2021)
        CEA with CskQ156Stop
        (Hirabayashi and Cagan, 2015)
        CEA with CskQ156Stop, InRA1325D.UAS
        (Hirabayashi and Cagan, 2015)
        model of  cancer
        CEA with fmt1
        (Ma et al., 2017)
        CEA with PpVΔ1
        (Ma et al., 2017)
        CEA with l(2)gl4
        (Guo et al., 2020, Ma et al., 2017, Ma et al., 2013, Pagliarini and Xu, 2003)
        CEA with PpVGD7532
        (Ma et al., 2017)
        CEA
        (Khalili et al., 2023, Martínez-Abarca Millán et al., 2023, Enomoto et al., 2021, Santabárbara-Ruiz and Léopold, 2021, Tamamouna et al., 2021, Ma et al., 2020, Jung et al., 2019, Rives-Quinto et al., 2017, Chabu and Xu, 2014, Hirabayashi et al., 2013, Ma et al., 2013)
        CEA with scrib673
        (Katheder et al., 2017, Pérez et al., 2017)
        CEA with scrib1
        (Kakemura and Igaki, 2024, Cong et al., 2021, Hodgson et al., 2021, Katheder et al., 2017, Figueroa-Clarevega and Bilder, 2015, Külshammer et al., 2015, Stickel and Su, 2014, Willoughby et al., 2013, Wu et al., 2010, Pagliarini and Xu, 2003)
        CEA with dlg1GD4689
        (Katheder et al., 2017, Muzzopappa et al., 2017, Figueroa-Clarevega and Bilder, 2015, Willecke et al., 2011)
        CEA with scribj7B3
        (Waghmare et al., 2024, Pagliarini and Xu, 2003)
        CEA with Src64BUAS.cCa
        (Enomoto et al., 2021)
        CEA with dlg114
        (Kakemura and Igaki, 2024, Pagliarini and Xu, 2003)
        CEA with baz4
        (Pagliarini and Xu, 2003)
        CEA with sdtXN
        (Pagliarini and Xu, 2003)
        CEA with Cdc421
        (Pagliarini and Xu, 2003)
        CEA with dorC107
        (Chi et al., 2010)
        CEA with dor8
        (Chi et al., 2010)
        CEA with dorD185
        (Chi et al., 2010)
        CEA with carRNAi.UAS
        (Chi et al., 2010)
        CEA with Vps16ARNAi.UAS.WIZ
        (Chi et al., 2010)
        CEA with upd1UAS.cUa
        (Wu et al., 2010)
        CEA with upd2UAS.cUa
        (Wu et al., 2010)
        CEA with upd1UAS.cUa, upd2UAS.cUa, upd3UAS.cUa
        (Wu et al., 2010)
        CEA with l(2)glunspecified
        (Xu et al., 2023, Wu et al., 2010)
        CEA with pnutGD1512
        (Gerlach et al., 2018)
        CEC with l(2)gl4
        (Ma et al., 2014)
        CEA with Hsap\S100A4wt.UAS
        (Ismail et al., 2017)
        CEA with scribRNAi.UAS.cUa
        (Hodgson et al., 2021)
        CEA with CskQ156Stop
        (Hirabayashi et al., 2013)
        CEA with scribKK101128
        (Muzzopappa et al., 2017)
        CEA with mudJF02911
        (Muzzopappa et al., 2017)
        CEA with mudHMS01458
        (Muzzopappa et al., 2017)
        CEA with NRNAi.P.UAS
        (Tamamouna et al., 2021)
        CEA with NDN.UAS.cUa
        (Xu et al., 2023)
        CEA with emeiGD3587
        (Ma et al., 2020)
        CEA with Rox8GD11645
        (Guo et al., 2020)
        CEA with BacA\p35UAS.cHa
        (Khalili et al., 2023)
        CEA with dlg1RNAi.UAS.cUa
        (Bakopoulos et al., 2023)
        model of  intestinal cancer
        CEA
        (Cabrera et al., 2023, Nászai et al., 2021)
        CEA with Apc2N175K, ApcQ8
        (Martorell et al., 2014, Martorell et al., 2014)
        model of  colorectal cancer
        CEA
        (Bangi et al., 2012)
        model of  leukemia
        CEA
        (Arefin et al., 2017)
        CEA with l(2)glKK100777
        (Arefin et al., 2017)
        CEA with scribKK101128
        (Arefin et al., 2017)
        model of  benign neoplasm
        CEA with Alg9c02021
        (de Vreede et al., 2018)
        DOES NOT model  cancer
        CEA with Hsap\S100A4Δ2.UAS
        (Ismail et al., 2017)
        model of  heart disease
        CEA
        (Karekar et al., 2021)
        model of  prostate cancer
        CEA
        (Rambur et al., 2020)
        model of  high grade glioma
        CEA
        (Kumar et al., 2024)
        CEA with PtenRNAi.UAS.cUa
        (Cheng et al., 2016)
        model of  kidney cancer
        CEA
        (Zeng et al., 2010)
        model of  ovarian carcinoma
        CEA with aPKCΔN.UAS
        (Hsi et al., 2023)
        model of  hypertrophic cardiomyopathy
        CEA
        (Petersen et al., 2022)
        Ras85DV12.ey
        model of  carcinoma
        CEC
        (Karim and Rubin, 1998)
        Ras85DV12.cUa.UAS
        model of  cervical cancer
        CEA
        (Padash Barmchi et al., 2016)
        CEA with Hsap\UBE3AUAS.cRa, HPV18\E6UAS.Tag:MYC
        (Padash Barmchi et al., 2016)
        CEA with Hsap\UBE3AUAS.cRa, HPV18\E6V158A.UAS.Tag:MYC
        (Padash Barmchi et al., 2016)
        model of  cancer
        CEA with l(2)gl4
        (Fangninou et al., 2023, Liu et al., 2022, Yang et al., 2022)
        CEA with Ptp61FΔ
        (Liu et al., 2022)
        CEA with Syx73119
        (Liu et al., 2022)
        CEA with Rabex-53672
        (Liu et al., 2022)
        CEA with Vps362586
        (Liu et al., 2022)
        CEA with TSG101P26
        (Liu et al., 2022)
        CEA with NDN.UAS.cUa
        (Lee et al., 2021)
        CEA with dlg1RNAi.UAS.cUa
        (Lodge et al., 2021)
        CEA
        (Yang et al., 2022, Dong et al., 2021, Yeom et al., 2021, Dunn et al., 2018, Vicente et al., 2018)
        CEA with scrib1
        (Yang et al., 2022, Khezri et al., 2021)
        CEA with baz4
        (Yang et al., 2022)
        CEA with fmt1
        (Yang et al., 2022)
        CEA with dlg1GD4689
        (Yang et al., 2022)
        CEA with Ptip3804
        (Dong et al., 2021)
        model of  colorectal cancer
        CEA
        (Zipper et al., 2022)
        CEA with PtensgRNA.UAS
        (Zipper et al., 2022)
        CEA with MedsgRNA.UAS
        (Zipper et al., 2022)
        CEA with cicsgRNA.UAS
        (Zipper et al., 2022)
        CEA with Apc2sgRNA.UAS
        (Zipper et al., 2022)
        CEA with ApcsgRNA.UAS
        (Zipper et al., 2022)
        CEA with p53sgRNA.UAS
        (Zipper et al., 2022)
        CEA with p53RNAi.UAS.cUa, PtenGD13500, ApcRNAi.UAS.cUa, MedRNAi.UAS.cUa
        (Bangi et al., 2016)
        CEA with p53RNAi.UAS.cUa, PtenGD13500, ApcRNAi.UAS.cUa
        (Bangi et al., 2016)
        CEA with p53RNAi.UAS.cUa, ApcRNAi.UAS.cUa, MedRNAi.UAS.cUa
        (Bangi et al., 2016)
        CEA with PtenGD13500, ApcRNAi.UAS.cUa, MedRNAi.UAS.cUa
        (Bangi et al., 2016)
        model of  cardiomyopathy
        CEA
        (Yu et al., 2013)
        model of  adenocarcinoma
        CEA with l(2)glGD4047
        (Casas-Tintó et al., 2016)
        CEA with l(2)glGD4047, wupAJF02172
        (Casas-Tintó et al., 2016)
        model of  carcinoma
        CEA
        (Guo et al., 2024, Hogan et al., 2009)
        CEA with l(2)gl4
        (Sun et al., 2019)
        CEA with dlg1HMS00172
        (Toggweiler et al., 2016)
        model of  intestinal cancer
        CEA with ApcQ8
        (Campbell et al., 2019)
        CEA
        (Kim et al., 2022, Dai et al., 2020, Singh et al., 2016)
        CEA with Apc2N175K, ApcQ8
        (Parisi et al., 2023)
        CEA with ApcGD1333, p53GD4483
        (Quintero and Bangi, 2023)
        CEA with ApcGD1333, PtenRNAi.UAS.cUa, p53GD4483
        (Quintero and Bangi, 2023)
        CEA with ApcGD1333, MedGD1483, p53GD4483
        (Quintero and Bangi, 2023)
        model of  high grade glioma
        CEA with PtenRNAi.Exel.UAS
        (Gangwani et al., 2020)
        CEA
        (Liu et al., 2021)
        model of  brain cancer
        CEA with dlg1GD4689
        (Manzanero-Ortiz et al., 2021)
        CEA with l(2)glKK100777
        (Manzanero-Ortiz et al., 2021)
        CEA with wtsKK101055
        (Manzanero-Ortiz et al., 2021)
        CEA with scrib673
        (Manzanero-Ortiz et al., 2021)
        Ras85DV152G.UASp
        model of  Noonan syndrome 3
        CEA
        (Cattaneo et al., 2020)
        Ras85DG12V.UAS.Tag:FLAG,Tag:polyHis
        model of  cancer
        CEA
        (Washington et al., 2020)
        Ras85DY4F.G12V.UAS.Tag:FLAG,Tag:polyHis
        model of  cancer
        CEA
        (Washington et al., 2020)
        Ras85DV12.QUAS.cHa
        model of  cancer
        CEA with scrib1
        (Hodgson et al., 2021)
        Ras85DV12.QUAS.cLa
        model of  cancer
        CEA with scribQUAS.HMS01490
        (Bakopoulos et al., 2023, Lodge et al., 2021)
        Ras85DG12D.UAS.cSa
        model of  pancreatic ductal adenocarcinoma
        CEA with CycEUAS.Tag:HA.Medsh, MedRNAi.UAS.CycE-HA, p53RNAi.UAS.RasG12D
        (Sekiya et al., 2023)
        Ras85DG12D.UAS.p53sh
        model of  pancreatic ductal adenocarcinoma
        CEA with CycEUAS.Tag:HA.Medsh, MedRNAi.UAS.CycE-HA, p53RNAi.UAS.RasG12D
        (Sekiya et al., 2023)
        Modifiers Based on Experimental Evidence ( 19 )
        Allele
        Disease
        Interaction
        References
        Ras85DHMS01294
        ameliorates  hematologic cancer
        modeled by mxc1
        (Kurihara et al., 2020)
        Ras85DΔC40B
        ameliorates  multiple endocrine neoplasia type 2B
        modeled by RetMEN2B.GMR
        (Read et al., 2005)
        Ras85D06677
        ameliorates  autosomal dominant cerebellar ataxia
        modeled by Hsap\ATXN182Q.UAS
        (Park et al., 2013)
        ameliorates  multiple endocrine neoplasia type 2B
        modeled by RetMEN2B.GMR
        (Read et al., 2005)
        ameliorates  multiple endocrine neoplasia type 2A
        modeled by RetMEN2A.GMR
        (Read et al., 2005)
        ameliorates  alveolar rhabdomyosarcoma
        modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
        (Galindo et al., 2006)
        Ras85DG13Q.UAS
        model of  cancer
        is exacerbated by ITPUAS.F
        (Xu et al., 2023)
        Ras85DN17.UAS
        ameliorates  brain glioma
        modeled by btl::Egfrλ.UAS, Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
        (Read et al., 2009)
        Ras85DQ13.UAS
        model of  cancer
        is ameliorated by CatUAS.cAa
        (Tamamouna et al., 2021)
        is ameliorated by Sod1UAS.cAa
        (Tamamouna et al., 2021)
        is ameliorated by btlDN.UAS
        (Tamamouna et al., 2021)
        Ras85DV12.GMR
        model of  cancer
        is ameliorated by InRGL00139
        (Okada et al., 2023)
        is ameliorated by InRJF01183
        (Okada et al., 2023)
        is ameliorated by InRJF01482
        (Okada et al., 2023)
        is ameliorated by NetBVSH330183
        (Okada et al., 2023)
        is ameliorated by InRK1409A.UAS
        (Okada et al., 2023)
        is ameliorated by NetBΔ
        (Okada et al., 2023)
        is ameliorated by NetBKK103672
        (Okada et al., 2023)
        is ameliorated by unc-5HMS01099
        (Okada et al., 2023)
        is ameliorated by unc-5KK102074
        (Okada et al., 2023)
        is ameliorated by unc-5MI04273
        (Okada et al., 2023)
        Ras85DV12.UAS
        model of  carcinoma
        is exacerbated by mysRNAi.UAS.cUa
        (Martínez-Abarca Millán and Martín-Bermudo, 2023)
        is exacerbated by mysRNAi.UAS.cUa
        (Martínez-Abarca Millán and Martín-Bermudo, 2023)
        is ameliorated by Atg1GD7149
        (Pérez et al., 2015)
        is ameliorated by HAdV-C\E4orf4UAS.cPa
        (Rosen et al., 2019)
        is ameliorated by HAdV-C\E4orf4UAS.cPb
        (Rosen et al., 2019)
        is exacerbated by dapHMS01610
        (Ito and Igaki, 2021)
        is exacerbated by dapHMS05362
        (Ito and Igaki, 2021)
        is ameliorated by pntP1.UAS
        (Ito and Igaki, 2021)
        is exacerbated by hepAct.UAS
        (Uhlirova and Bohmann, 2006)
        is exacerbated by egrUAS.cIa
        (Igaki et al., 2006)
        is exacerbated by ZnT86DKK101698
        (Wei et al., 2021)
        is exacerbated by msn172
        (Kong et al., 2021)
        is exacerbated by msn3208
        (Kong et al., 2021)
        is exacerbated by snaUAS.cAa
        (Wu et al., 2021)
        is exacerbated by l(2)gl4
        (Wu et al., 2021)
        is ameliorated by rlGD4697
        (Murcia et al., 2019)
        is ameliorated by RafDN.UAS
        (Zoranovic et al., 2018)
        is exacerbated by Tsp29FbGD1018
        (Zoranovic et al., 2018)
        is ameliorated by Tsp29FbUAS.Tag:HA
        (Zoranovic et al., 2018)
        is ameliorated by Hsap\CDKN1AUAS.cHa
        (Karim and Rubin, 1998)
        is ameliorated by RafXS-2541
        (Karim and Rubin, 1998)
        is exacerbated by rlSem
        (Karim and Rubin, 1998)
        is exacerbated by EgfrapΔSH2
        (Soler Beatty et al., 2021)
        is exacerbated by EgfrapHMJ23378
        (Soler Beatty et al., 2021)
        is exacerbated by EgfrapLS
        (Soler Beatty et al., 2021)
        is exacerbated by EgfrapL
        (Soler Beatty et al., 2021)
        is exacerbated by PVRAPHMJ23233
        (Soler Beatty et al., 2021)
        model of  cancer
        is ameliorated by Sec15KK101708
        (Chabu and Xu, 2014)
        is ameliorated by Sec8KK101531
        (Chabu and Xu, 2014)
        is ameliorated by Sec6GD11616
        (Chabu and Xu, 2014)
        is ameliorated by Sec151
        (Chabu and Xu, 2014)
        is ameliorated by Sec15GD12109
        (Chabu and Xu, 2014)
        is ameliorated by Src64BGD12263
        (Ma et al., 2013)
        is ameliorated by DroncNIG.8091R
        (Waghmare et al., 2024)
        is ameliorated by bskDN.UAS
        (Waghmare et al., 2024)
        is ameliorated by sggS9A.UAS
        (Waghmare et al., 2024)
        is ameliorated by ykiRNAi.N.UAS
        (Waghmare et al., 2024)
        is ameliorated by ykiRNAi.C.UAS
        (Waghmare et al., 2024)
        is ameliorated by chinmo1
        (Enomoto et al., 2021)
        is exacerbated by PVRAP1
        (Martínez-Abarca Millán et al., 2023)
        is exacerbated by PVRAPHMJ23233
        (Martínez-Abarca Millán et al., 2023)
        is exacerbated by by33c
        (Martínez-Abarca Millán et al., 2023)
        is exacerbated by byVSH330366
        (Martínez-Abarca Millán et al., 2023)
        is exacerbated by CskQ156Stop
        (Hirabayashi et al., 2013)
        is exacerbated by emei1
        (Ma et al., 2020)
        is exacerbated by emei2
        (Ma et al., 2020)
        is exacerbated by emei3
        (Ma et al., 2020)
        is ameliorated by Arc1esm18
        (Khalili et al., 2023)
        is exacerbated by Nek2UAS.GFP
        (Das et al., 2013)
        model of  intestinal cancer
        is ameliorated by CortactinHMS00658
        (Cabrera et al., 2023)
        is ameliorated by CortactinKK108594
        (Cabrera et al., 2023)
        is ameliorated by shgHMS00693
        (Cabrera et al., 2023)
        is ameliorated by shgJF02769
        (Cabrera et al., 2023)
        exacerbates  alveolar rhabdomyosarcoma
        modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
        (Galindo et al., 2006)
        exacerbates  gastrointestinal system cancer
        modeled by Apc2g10, ApcQ8
        (Wang et al., 2013)
        model of  colorectal cancer
        is ameliorated by TimpUAS.cPa
        (Bangi et al., 2012)
        is ameliorated by JraNIG.2275R
        (Bangi et al., 2012)
        is ameliorated by bskDN.UAS
        (Bangi et al., 2012)
        is ameliorated by bskHMS00777
        (Bangi et al., 2012)
        is exacerbated by hepAct.UAS
        (Bangi et al., 2012)
        is exacerbated by imdUAS.cGa
        (Bangi et al., 2012)
        ameliorates  cancer
        modeled by dlg1A40.2
        (Parisi et al., 2014)
        exacerbates  carcinoma
        modeled by scrib1
        (Brumby and Richardson, 2003)
        modeled by armUAS.Exel
        (Zhang et al., 2019)
        model of  prostate cancer
        is ameliorated by EgfrGD1654
        (Rambur et al., 2020)
        is ameliorated by Pi3K92EHMC05152
        (Rambur et al., 2020)
        is ameliorated by mTorGL00156
        (Rambur et al., 2020)
        is ameliorated by rlHMS00173
        (Rambur et al., 2020)
        is ameliorated by spiHMS01120
        (Rambur et al., 2020)
        exacerbates  intestinal cancer
        modeled by Rab11KK108297
        (Nie et al., 2019)
        exacerbates  cancer
        modeled by HipkUAS.Tag:HA
        (Blaquiere et al., 2018)
        model of  kidney cancer
        is ameliorated by Pka-C1B3
        (Zeng et al., 2010)
        is ameliorated by mTorΔP
        (Zeng et al., 2010)
        exacerbates  Alzheimer's disease 1
        modeled by Hsap\APPAβ42.UAS.cUa
        (Cheng et al., 2021)
        exacerbates  hematologic cancer
        modeled by mxc1
        (Kurihara et al., 2020)
        Ras85DV12.ey
        model of  carcinoma
        is ameliorated by RafXS-2541
        (Karim and Rubin, 1998)
        Ras85De1B
        ameliorates  alveolar rhabdomyosarcoma
        modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
        (Galindo et al., 2006)
        exacerbates  viral infectious disease
        modeled by EBV\BZLF1GMR.PA
        (Adamson and Lajeunesse, 2012)
        exacerbates  infectious mononucleosis
        modeled by EBV\BZLF1GMR.PA
        (Adamson and Lajeunesse, 2012)
        exacerbates  Epstein-Barr virus hepatitis
        modeled by EBV\BZLF1GMR.PA
        (Adamson and Lajeunesse, 2012)
        ameliorates  gastrointestinal system cancer
        modeled by Apc2g10, ApcQ8
        (Wang et al., 2013)
        exacerbates  tuberous sclerosis
        modeled by Tsc1UAS.cTa, gigUAS.cTa
        (Tapon et al., 2001)
        ameliorates  cancer
        modeled by AlkUAS.cLa
        (Wolfstetter et al., 2020)
        Ras85De2F
        ameliorates  alveolar rhabdomyosarcoma
        modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
        (Galindo et al., 2006)
        Ras85Dunspecified
        ameliorates  neurofibromatosis
        modeled by Nf1E2
        (Walker et al., 2006)
        Ras85DV12.cUa.UAS
        model of  cancer
        is exacerbated by Ptp61FΔ
        (Liu et al., 2022)
        is exacerbated by exe1
        (Liu et al., 2022)
        is exacerbated by Not3KK102144
        (Vicente et al., 2018)
        is exacerbated by M6W186stop
        (Dunn et al., 2018)
        is ameliorated by Ptip3804
        (Dong et al., 2021)
        is exacerbated by p53UAS.cUa
        (Dong et al., 2021)
        is ameliorated by Ilp8MI00727
        (Yeom et al., 2021)
        model of  intestinal cancer
        is ameliorated by CortactinHMS00658
        (Kim et al., 2022)
        is exacerbated by Clbn1Q
        (Dai et al., 2020)
        model of  high grade glioma
        is ameliorated by Dcp-1RNAi.UAS.cUa
        (Liu et al., 2021)
        is exacerbated by NmnatUAS.PC
        (Liu et al., 2021)
        is ameliorated by NmnatRNAi.UAS.cUa
        (Liu et al., 2021)
        exacerbates  carcinoma
        modeled by NkapGD11807
        (Guo et al., 2024)
        model of  carcinoma
        is exacerbated by NkapGD11807
        (Guo et al., 2024)
        Ras85DGD12553
        ameliorates  colorectal cancer
        modeled by Src42ACA.UAS
        (Cordero et al., 2014)
        modeled by Src64BUAS.cCa
        (Cordero et al., 2014)
        ameliorates  neurofibromatosis
        modeled by Nf1JF01866
        (Georganta et al., 2021)
        Ras85DKK108029
        ameliorates  colorectal cancer
        modeled by Src42ACA.UAS
        (Cordero et al., 2014)
        modeled by Src64BUAS.cCa
        (Cordero et al., 2014)
        ameliorates  intestinal cancer
        modeled by EgfrUAS.cBa
        (Nászai et al., 2021)
        Ras85DJF02478
        ameliorates  colorectal cancer
        modeled by SH3PX1HMJ21552
        (Zhang et al., 2019)
        Ras85DG12V.UAS.Tag:FLAG,Tag:polyHis
        model of  cancer
        is exacerbated by Egfr2.UAS
        (Washington et al., 2020)
        is ameliorated by Rabex-5DPYT.UAS.Tag:MYC
        (Washington et al., 2020)
        is exacerbated by hopJF01267
        (Washington et al., 2020)
        Ras85DY4F.G12V.UAS.Tag:FLAG,Tag:polyHis
        model of  cancer
        is exacerbated by Egfr2.UAS
        (Washington et al., 2020)
        is ameliorated by Rabex-5DPYT.UAS.Tag:MYC
        (Washington et al., 2020)
        Ras85DDN.UAS.cUa
        ameliorates  Alzheimer's disease 1
        modeled by Hsap\APPAβ42.UAS.cUa
        (Cheng et al., 2021)
        p53
        Models Based on Experimental Evidence ( 11 )
        Allele
        Disease
        Evidence
        References
        p53259H.GUS
        model of  cancer
        CEA
        (Sidorov and Belitskii, 2002)
        p535A-1-4
        model of  testicular cancer
        CEA
        (Napoletano et al., 2017)
        model of  cancer
        CEA
        (de la Cova et al., 2014)
        p53E8
        model of  testicular cancer
        CEA
        (Napoletano et al., 2017)
        p53H159N.UAS.Ex
        DOES NOT model  cancer
        CEA with pnutGD1512
        (Gerlach et al., 2018)
        p53GD4483
        model of  intestinal cancer
        CEA with ApcGD1333, Ras85DV12.cUa.UAS
        (Quintero and Bangi, 2023)
        CEA with ApcGD1333, PtenRNAi.UAS.cUa, Ras85DV12.cUa.UAS
        (Quintero and Bangi, 2023)
        CEA with ApcGD1333, MedGD1483, Ras85DV12.cUa.UAS
        (Quintero and Bangi, 2023)
        model of  cancer
        CEA with MycUAS.cZa
        (Diaz et al., 2024)
        p53GD11134
        model of  testicular cancer
        CEA
        (Napoletano et al., 2017)
        p53TM3
        model of  cancer
        CEA with p53-ns, Hsap\TP53R175H
        (D'Brot et al., 2017)
        CEA with p53-ns, Hsap\TP53G245S
        (D'Brot et al., 2017)
        CEA with p53-ns, Hsap\TP53R248Q
        (D'Brot et al., 2017)
        CEA with p53-ns, Hsap\TP53R273C
        (D'Brot et al., 2017)
        CEA with p53-ns, Hsap\TP53R273H
        (D'Brot et al., 2017)
        p53-ns
        model of  cancer
        CEA with p53TM3, Hsap\TP53R175H
        (D'Brot et al., 2017)
        CEA with p53TM3, Hsap\TP53G245S
        (D'Brot et al., 2017)
        CEA with p53TM3, Hsap\TP53R248Q
        (D'Brot et al., 2017)
        CEA with p53TM3, Hsap\TP53R273C
        (D'Brot et al., 2017)
        CEA with p53TM3, Hsap\TP53R273H
        (D'Brot et al., 2017)
        p53sgRNA.UAS
        model of  colorectal cancer
        CEA with Ras85DV12.cUa.UAS
        (Zipper et al., 2022)
        p53RNAi.UAS.RasG12D
        model of  pancreatic ductal adenocarcinoma
        CEA with CycEUAS.Tag:HA.Medsh, MedRNAi.UAS.CycE-HA, Ras85DG12D.UAS.p53sh
        (Sekiya et al., 2023)
        CEA with CycEUAS.Tag:HA.Medsh, MedRNAi.UAS.CycE-HA, Ras85DG12D.UAS.cSa
        (Sekiya et al., 2023)
        model of  cancer
        CEA with MycUAS.cZa
        (Diaz et al., 2024)
        p53RNAi.UAS.cUa
        model of  colorectal cancer
        CEA with Ras85DV12.cUa.UAS, PtenGD13500, ApcRNAi.UAS.cUa, MedRNAi.UAS.cUa
        (Bangi et al., 2016)
        CEA with Ras85DV12.cUa.UAS, PtenGD13500, ApcRNAi.UAS.cUa
        (Bangi et al., 2016)
        CEA with Ras85DV12.cUa.UAS, ApcRNAi.UAS.cUa, MedRNAi.UAS.cUa
        (Bangi et al., 2016)
        Modifiers Based on Experimental Evidence ( 15 )
        Allele
        Disease
        Interaction
        References
        p5311-1B-1
        ameliorates  Alexander disease
        modeled by Hsap\GFAPR79H.UAS
        (Wang et al., 2015)
        exacerbates  tauopathy
        modeled by Hsap\MAPTR406W.UAS
        (Merlo et al., 2014)
        ameliorates  brain ischemia
        modeled by Mmus\Gria1Lc.UAS
        (Lei et al., 2017)
        p53259H.GUS
        exacerbates  Alzheimer's disease 1
        modeled by Hsap\APPArctic.Aβ42.UAS.Tag:SS(rPENK)
        (Iijima et al., 2010)
        p535A-1-4
        ameliorates  Huntington's disease
        modeled by Hsap\HTTGMR.Q120
        (Bae et al., 2005)
        ameliorates  cytochrome-c oxidase deficiency disease
        modeled by ScoxGD898
        (Martínez-Morentin et al., 2015)
        exacerbates  tauopathy
        modeled by Hsap\MAPTR406W.UAS
        (Merlo et al., 2014)
        p53Ct.GUS
        exacerbates  Alzheimer's disease 1
        modeled by Hsap\APPArctic.Aβ42.UAS.Tag:SS(rPENK)
        (Iijima et al., 2010)
        p53GMR.Ex
        ameliorates  viral infectious disease
        modeled by EBV\BRLF1GMR.PA
        (Adamson and Lajeunesse, 2012)
        exacerbates  viral infectious disease
        modeled by EBV\BZLF1GMR.PA
        (Adamson and Lajeunesse, 2012)
        ameliorates  infectious mononucleosis
        modeled by EBV\BRLF1GMR.PA
        (Adamson and Lajeunesse, 2012)
        exacerbates  infectious mononucleosis
        modeled by EBV\BZLF1GMR.PA
        (Adamson and Lajeunesse, 2012)
        ameliorates  Epstein-Barr virus hepatitis
        modeled by EBV\BRLF1GMR.PA
        (Adamson and Lajeunesse, 2012)
        exacerbates  Epstein-Barr virus hepatitis
        modeled by EBV\BZLF1GMR.PA
        (Adamson and Lajeunesse, 2012)
        p53R155H.UAS.Ex
        ameliorates  ataxia telangiectasia
        modeled by tefuΔ356
        (Song et al., 2004)
        ameliorates  cancer
        modeled by Ptip3804, Ras85DV12.cUa.UAS
        (Dong et al., 2021)
        p53GL01032
        ameliorates  C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis
        modeled by Zzzz\GGGGCC30.UAS.EGFP
        (Maor-Nof et al., 2021)
        p53GD11134
        model of  testicular cancer
        is NOT exacerbated by HtrA2DF1
        (Napoletano et al., 2017)
        p53KK113065
        ameliorates  cancer
        modeled by Ptip3804, Ras85DV12.cUa.UAS
        (Dong et al., 2021)
        p53JF02513
        ameliorates  Alexander disease
        modeled by Hsap\GFAPR79H.UAS
        (Wang et al., 2015)
        p53GL01220
        ameliorates  C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis
        modeled by Zzzz\GGGGCC30.UAS.EGFP
        (Maor-Nof et al., 2021)
        exacerbates  amyotrophic lateral sclerosis type 1
        modeled by Hsap\SOD1A4V.UAS
        (Lu et al., 2019)
        exacerbates  C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis
        modeled by Zzzz\poly-PRPO-100.UAS
        (Lu et al., 2019)
        p53UAS.cUa
        exacerbates  cytochrome-c oxidase deficiency disease
        modeled by ScoxGD898
        (Martínez-Morentin et al., 2015)
        exacerbates  brain ischemia
        modeled by Mmus\Gria1Lc.UAS
        (Lei et al., 2017)
        exacerbates  cancer
        modeled by Ras85DV12.cUa.UAS
        (Dong et al., 2021)
        p53HMS02286
        ameliorates  C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis
        modeled by Zzzz\GGGGCC30.UAS.EGFP
        (Maor-Nof et al., 2021)
        p53DN.UAS.cUa
        ameliorates  cytochrome-c oxidase deficiency disease
        modeled by ScoxGD898
        (Martínez-Morentin et al., 2015)
        ameliorates  brain cancer
        modeled by dpnUAS.cUa
        (Morrissy et al., 2016)
        p53RNAi.UAS.cUa
        ameliorates  Alzheimer's disease 1
        modeled by Hsap\APPT12.Aβ42.UAS.Tag:SS(nec)
        (Taylor and Tuxworth, 2019)
        Apc
        Models Based on Experimental Evidence ( 4 )
        Modifiers Based on Experimental Evidence ( 1 )
        Allele
        Disease
        Interaction
        References
        ApcQ8
        model of  colorectal cancer
        is ameliorated by ewgP1
        (Tian et al., 2017)
        model of  familial adenomatous polyposis 1
        is ameliorated by Hsap\APCUAS.cBa
        (Bhandari and Shashidhara, 2001)
        Pten
        Models Based on Experimental Evidence ( 9 )
        Modifiers Based on Experimental Evidence ( 4 )
        Allele
        Disease
        Interaction
        References
        PtenUAS.cUa
        ameliorates  brain glioma
        modeled by btl::Egfrλ.UAS, Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
        (Read et al., 2009)
        exacerbates  Alzheimer's disease 1
        modeled by Hsap\APPAβ42.UAS.cBa
        (Hwang et al., 2019)
        ameliorates  Huntington's disease
        modeled by Hsap\HTTN548.Q128.UAS
        (Martin et al., 2021)
        PtenUAS.cGb
        ameliorates  Alzheimer's disease 1
        modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
        (Chiang et al., 2010)
        PtenGD13500
        exacerbates  cancer
        modeled by MycUAS.cZa, p53RNAi.UAS.RasG12D
        (Diaz et al., 2024)
        PtenKK109278
        ameliorates  chromosome 16p11.2 deletion syndrome, 593-kb
        modeled by Pp4-19CGD9561
        (Iyer et al., 2018)
        model of  cancer
        is exacerbated by B52KK108253
        (Parniewska and Stocker, 2020)
        is ameliorated by Zrf1KK102428
        (Parniewska and Stocker, 2020)
        is ameliorated by GirdinKK101725
        (Parniewska and Stocker, 2020)
        is ameliorated by Mo25GD11213
        (Parniewska and Stocker, 2020)
        is ameliorated by OsbpKK107784
        (Parniewska and Stocker, 2020)
        is ameliorated by SF2GD12097
        (Parniewska and Stocker, 2020)
        is ameliorated by SF2HM05199
        (Parniewska and Stocker, 2020)
        is ameliorated by S6kKK107986
        (Parniewska and Stocker, 2020)
        is ameliorated by SRPKKK100641
        (Parniewska and Stocker, 2020)
        is ameliorated by SlikGD11338
        (Parniewska and Stocker, 2020)
        is ameliorated by SF2HMS00358
        (Parniewska and Stocker, 2020)
        is ameliorated by chicoKK107581
        (Parniewska and Stocker, 2020)
        is exacerbated by Srp54GD10663
        (Parniewska and Stocker, 2020)
        is ameliorated by cicKK112641
        (Parniewska and Stocker, 2020)
        is ameliorated by Vha100-1KK105748
        (Parniewska and Stocker, 2020)
        is ameliorated by brpKK108677
        (Parniewska and Stocker, 2020)
        is ameliorated by maskKK100529
        (Parniewska and Stocker, 2020)
        is ameliorated by mib1GD11786
        (Parniewska and Stocker, 2020)
        is ameliorated by ttvGD1993
        (Parniewska and Stocker, 2020)
        is ameliorated by zfh1KK109931
        (Parniewska and Stocker, 2020)
        is ameliorated by tra2KK108747
        (Parniewska and Stocker, 2020)
        Med
        Models Based on Experimental Evidence ( 6 )
        Modifiers Based on Experimental Evidence ( 5 )
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Related mammalian, viral, bacterial, or synthetic transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Ras85DV152G.UASp
        P{UASp-Ras85D.V152G}
        Ras85DG12V.UAS.Tag:FLAG,Tag:polyHis
        P{UAS-FH-Ras85D.G12V}
        Ras85DY4F.G12V.UAS.Tag:FLAG,Tag:polyHis
        P{UAS-FH-Ras85D.Y4F.G12V}
        Ras85DV12.QUAS.cHa
        P{QUAS-Ras85D.V12.H}
        Ras85DV12.QUAS.cLa
        PBac{QUAS-Ras85D.V12.L}
        Ras85DDN.UAS.cUa
        P{UAS-Ras85D.DN.U}
        Ras85DG12D.UAS.cSa
        P{UAS-Ras85D.G23D.S}
        Ras85DG12D.UAS.p53sh
        P{UAS-Ras85D(G12D).UAS-p53(shRNA)}
        Ras85DV12.UAS
        P{UAS-Ras85D.V12}
        w1118; P{UAS-Ras85D.V12}TL1
        Ras85DN17.UAS
        P{UAS-Ras85D.N17}
        P{UAS-Ras85D.N17}TL1, w1118
        Ras85DG13Q.UAS
        P{UAS-Ras85B.Act}
        Ras85DV12.ey
        P{eyEh-Ras1V12}
        Ras85DV12.S35.UAS
        P{UAS-Ras85D.V12.S35}
        Ras85DQ13.UAS
        P{UAS-Ras85D.Q13}
        Ras85DV12.GMR
        P{GMR-Ras85D.V12}
        Ras85DG12V.UAS
        P{UAS-Ras85D.G12V}
        Ras85DV12.cUa.UAS
        P{UAS-Ras85D.V12.U}
        p53sgRNA.UAS
        P{UAS-Apc,Apc2,p53,Med,Pten,cic.sgRNA}
        p53Ct.GUS
        P{GUS-p53.Ct}
        w1118; P{GUS-p53.Ct}3.1/TM6B, Tb1
        p53259H.GUS
        P{GUS-p53.259H}
        w1118; P{GUS-p53.259H}3.1
        p53R155H.UAS.Ex
        P{UAS-p53.R155H.Ex}
        y1 w1118; P{UAS-p53.R155H.Ex}2/T(2;3)TSTL, CyO: TM6B, Tb+
        p53H159N.UAS.Ex
        P{UAS-p53.H159N.Ex}
        y1 w1118; P{UAS-p53.H159N.Ex}2
        p53GMR.Ex
        P{GMR-p53.Ex}
        P{GMR-p53.Ex}1, y1 w1118/FM7c
        p53UAS.cUa
        P{UAS-p53.U}
        p53DN.UAS.cUa
        P{UAS-p535.DN.U}
        ApcsgRNA.UAS
        P{UAS-Apc,Apc2,p53,Med,Pten,cic.sgRNA}
        PtensgRNA.UAS
        P{UAS-Apc,Apc2,p53,Med,Pten,cic.sgRNA}
        PtenUAS.cGb
        P{UAS-Pten.Gb}
        PtenUAS.cUa
        P{UAS-Pten.U}
        MedHD_CFD00386
        P{HD_CFD00386}
        P{hsFLP}1, y1 w1118; P{HD_CFD00386}attP40/CyO-GFP
        MedsgRNA.UAS
        P{UAS-Apc,Apc2,p53,Med,Pten,cic.sgRNA}
        MedHD_CFD00386
        P{HD_CFD00386}
        P{hsFLP}1, y1 w1118; P{HD_CFD00386}attP40/CyO-GFP
        MedsgRNA.UAS
        P{UAS-Apc,Apc2,p53,Med,Pten,cic.sgRNA}
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Ras85DTH201501177.S
        P{TH201501177.S}
        Ras85DRNAi.UAS.cUa
        P{UAS-Ras85D.RNAi.U}
        Ras85DGD12553
        P{GD12553}
        w1118; P{GD12553}v28129
        Ras85DKK108029
        P{KK108029}
        P{KK108029}VIE-260B
        Ras85DJF02478
        P{TRiP.JF02478}
        y1 v1; P{TRiP.JF02478}attP2
        Ras85DNIG.9375R
        P{NIG.9375R}
        Ras85DHMS01294
        P{TRiP.HMS01294}
        y1 sc* v1 sev21; P{TRiP.HMS01294}attP2
        Ras85DGL00336
        P{TRiP.GL00336}
        y1 sc* v1 sev21; P{TRiP.GL00336}attP2/TM3, Sb1
        p53RNAi.sg
        PBac{sg-p53.RNAi}
        p53RNAi.UAS.RasG12D
        P{UAS-Ras85D(G12D).UAS-p53(shRNA)}
        p53RNAi.UAS.cUa
        P{UAS-p53.RNAi.U}
        p53GD4483
        P{GD4483}
        w1118; P{GD4483}v10692
        p53GD11134
        P{GD11134}
        w1118; P{GD11134}v45139
        p53KK113065
        P{KK113065}
        P{KK113065}VIE-260B
        p53RNAi.UAS
        P{UAS-p53.RNAi}
        p53JF02513
        P{TRiP.JF02513}
        y1 v1; P{TRiP.JF02513}attP2
        p53GL01032
        P{TRiP.GL01032}
        y1 sc* v1 sev21; P{TRiP.GL01032}attP2
        p53NIG.10873R
        P{NIG.10873R}
        P{NIG.10873R}1
        p53GL01220
        P{TRiP.GL01220}
        y1 v1; P{TRiP.GL01220}attP40
        p53HMS02286
        P{TRiP.HMS02286}
        y1 sc* v1 sev21; P{TRiP.HMS02286}attP2
        ApcRNAi.UAS.cUa
        P{UAS-Apc.RNAi.U}
        ApcGD1333
        P{GD1333}
        w1118; P{GD1333}v51468
        ApcHM05070
        P{TRiP.HM05070}
        y1 v1; P{TRiP.HM05070}attP2
        ApcKK105718
        P{KK105718}
        P{KK105718}VIE-260B
        ApcHMS00188
        P{TRiP.HMS00188}
        y1 sc* v1 sev21; P{TRiP.HMS00188}attP2
        ApcNIG.1451R
        P{NIG.1451R}
        P{NIG.1451R}1
        PtenlexAop.HMS00044
        P{lexAop-HMS00044}
        PtenRNAi.Exel.UAS
        P{UAS-Pten.RNAi.Exel}
        P{UAS-Pten.RNAi.Exel}1, y1 w1118
        PtenGD13500
        P{GD13500}
        w1118; P{GD13500}v35731
        PtenJF01859
        P{TRiP.JF01859}
        y1 v1; P{TRiP.JF01859}attP2
        PtenJF01987
        P{TRiP.JF01987}
        y1 v1; P{TRiP.JF01987}attP2/TM3, Sb1
        PtenKK109278
        P{KK109278}
        P{KK109278}VIE-260B
        PtenHMS00044
        P{TRiP.HMS00044}
        y1 v1; P{TRiP.HMS00044}attP2
        PtenNIG.5671R
        P{NIG.5671R}
        P{NIG.5671R}1
        PtenRNAi.UAS.cUa
        P{UAS-Pten.RNAi.U}
        MedRNAi.UAS.cUa
        P{UAS-Med.RNAi.U}
        MedKK108412
        P{KK108412}
        P{KK108412}VIE-260B
        MedJF02218
        P{TRiP.JF02218}
        y1 v1; P{TRiP.JF02218}attP2
        MedGD1483
        P{GD1483}
        w1118; P{GD1483}v19688
        MedGL01313
        P{TRiP.GL01313}
        y1 sc* v1 sev21; P{TRiP.GL01313}attP40
        MedRNAi.UAS.cUa
        P{UAS-Med.RNAi.U}
        MedRNAi.UAS.CycE-HA
        PBac{UAS-CycE(HA).UAS-Med(shRNA)}
        MedKK108412
        P{KK108412}
        P{KK108412}VIE-260B
        MedJF02218
        P{TRiP.JF02218}
        y1 v1; P{TRiP.JF02218}attP2
        MedGD1483
        P{GD1483}
        w1118; P{GD1483}v19688
        MedGL01313
        P{TRiP.GL01313}
        y1 sc* v1 sev21; P{TRiP.GL01313}attP40
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        Ras85D06677
        P-element activity
        P{PZ}Ras85D06677 ry506/TM3, ryRK Sb1 Ser1
        Ras85De2F
        sev14; Ras85De2F/TM3, Sb1
        Ras85De1B
        ethyl methanesulfonate
        sev14; Ras85De1B/TM3, Sb1
        Ras85Dunspecified
        Ras85DΔC40B
        loss of function allele
        Ras85Dx7b
        loss of function allele
        P-element activity
        Ras85DΔ17b
        amorphic allele - genetic evidence
        p53TM3
        amorphic allele - genetic evidence
        p535A-1-4
        ends-in gene targeting
        y1 w1118; p535A-1-4
        p53E8
        amorphic allele - molecular evidence
        Delta2-3 transposase
        p53E4
        amorphic allele - molecular evidence
        Delta2-3 transposase
        p5311-1B-1
        ends-in gene targeting
        y1 w1118; p5311-1B-1
        p53-ns
        ends-in gene targeting
        w1118/Dp(1;Y)y+; TI{TI}p53-ns
        ApcQ8
        w*; P{neoFRT}82B sr1 e1 Apc2N175K ApcQ8/TM3, P{ActGFP}JMR2, Ser1
        PtenKO
        amorphic allele - molecular evidence
        CRISPR/Cas9
        w*; PtenKO/CyO
        Pten2L100
        Ptenc494
        loss of function allele
        ethyl methanesulfonate
        Pten117
        loss of function allele
        y1 w*; Pten117/CyO
        Med13
        ethyl methanesulfonate
        ru1 hry1 P{neoFRT}82B sr1 es Med13/TM3, Sb1
        Med15
        ethyl methanesulfonate
        Med17
        ethyl methanesulfonate
        Med8
        loss of function allele
        Med3
        loss of function allele
        ethyl methanesulfonate
        MedC246
        loss of function allele
        Med13
        ethyl methanesulfonate
        ru1 hry1 P{neoFRT}82B sr1 es Med13/TM3, Sb1
        Med15
        ethyl methanesulfonate
        Med17
        ethyl methanesulfonate
        Med8
        loss of function allele
        Med3
        loss of function allele
        ethyl methanesulfonate
        MedC246
        loss of function allele
        References (24)