Human Disease Model Report: tauopathies, heterochromatin decondensation and transposable element dysregulation

General Information

Name

tauopathies, heterochromatin decondensation and transposable element dysregulation

FlyBase ID

FBhh0001010

Disease Ontology Term

tauopathy

Parent Disease

OMIM

Overview

In postmortem human brain samples and in Drosophila models of tauopathy, significant changes in the pattern of transposable element (TE) transcription are observed, relative to healthy samples. Expression of either mutant or wild-type human tau (Hsap\MAPT) in the fly brain is sufficient to activate numerous TEs. Heterochromatin decondensation is observed; piwi protein is depleted; specific classes of piRNAs are depleted. Genetic manipulations that interfere with piRNAs increase both TE expression and tau-induced neurotoxicity; overexpression of piwi has the opposite effects.

Somatic mutations of the human PIN1 gene have been observed in postmortem brain samples of Alzheimer disease patients. The fly ortholog of PIN1 is dod. In the fly Hsap\MAPT tauopathy model, levels of the fly gene dod are strongly reduced in the fly brain. Restoration of dod levels suppresses the Hsap\MAPT-dependent phenotypes, including heterochromatin changes, TE upregulation, neurodegeneration, and fly motor defects.

See also the human disease model report 'tauopathies, MAPT-related' (FBhh0000101).

[updated Oct. 2021 by FlyBase; FBrf0222196]

Disease Summary Information

Disease Summary: tauopathies, heterochromatin decondensation and transposable element dysregulation

OMIM report

Human gene(s) implicated

Symptoms and phenotype

Genetics

Cellular phenotype and pathology

Molecular information

PIN1 encodes a peptidyl-prolyl cis/trans isomerase (PPIase) that specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. [Gene Cards, PIN1; 2021.10.16]

(FlyBase Curators, 2013-)

External links

Gene2Function (human gene): MAPT
Gene Cards: MAPT
MedlinePlus (gene): MAPT
MARRVEL (human gene): MAPT
NCBI (Entrez) gene: MAPT; microtubule associated protein tau

Disease synonyms

tauopathies, transposable element dysregulation

Related Diseases

Related human health report(s)

Huntington disease

tauopathies

tauopathies, MAPT-related

Ortholog Information

Human gene(s) in FlyBase

Hsap\MAPT

Human gene (HGNC)

Symbol / Name

MAPT; microtubule associated protein tau

D. melanogaster ortholog (based on DIOPT)

Dmel\tau

(DIOPT, 2013-)

Comments on ortholog(s)

Many to one: 3 human to 1 Drosophila. Three human genes, MAPT, MAP2 and MAP4, are orthologous to the fly gene Dmel\tau.

Other mammalian ortholog(s) used

D. melanogaster Gene Information (0)

Other Genes Used: Viral, Bacterial, Synthetic (0)

Summary of Physical Interactions (5 groups)

Hsap\MAPT

protein-protein

Interacting group

Assay

References

Hsap\MAPT - 14-3-3ε

affinity technology, western blot, anti tag coimmunoprecipitation, Identification by mass spectrometry, coimmunoprecipitation

(Prifti et al., 2022, Papanikolopoulou et al., 2018)

Hsap\MAPT - 14-3-3ζ

affinity technology, western blot, coimmunoprecipitation

(Papanikolopoulou et al., 2018)

Hsap\MAPT - Mical

anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry

(Prifti et al., 2022)

Hsap\MAPT - Nmnat

anti bait coimmunoprecipitation, anti tag western blot

(Ali et al., 2012)

Hsap\MAPT - tau

anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot

(Prifti et al., 2022)

Alleles Reported to Model Human Disease (Disease Ontology) (122 alleles)

Hsap\MAPT

Models Based on Experimental Evidence ( 120 )

Allele

Disease

Evidence

References

Hsap\MAPT^UAS.GFP

model of tauopathy

CEA

(Zhu et al., 2017)

Hsap\MAPT^UAS.wt

model of tauopathy

CEA

(Li et al., 2024, Li et al., 2023, Subramanian et al., 2021, Lee et al., 2020, Lee et al., 2020, Panchal and Tiwari, 2020, Wang et al., 2020, Frenkel-Pinter et al., 2017, Shmueli et al., 2017, Frenkel-Pinter et al., 2016, Chatterjee et al., 2009)

CEC

(Yang et al., 2024)

model of Parkinson's disease

CEC

(Roy and Jackson, 2014)

model of Alzheimer's disease

CEA

(Frenkel-Pinter et al., 2016)

Hsap\MAPT^UAS.S2A

model of tauopathy

CEA

(Papanikolopoulou et al., 2010)

Hsap\MAPT^GMR.S11A

model of tauopathy

CEA

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ

model of tauopathy

CEA

(Zhou et al., 2024, Oliveira et al., 2023, Park et al., 2021, Chatterjee et al., 2019, Bakhoum et al., 2014, Ambegaokar and Jackson, 2010, Karsten et al., 2006, Jackson et al., 2002)

CEC

(Kim et al., 2015, Means et al., 2015, Park et al., 2012, Ambegaokar and Jackson, 2011, Dermaut et al., 2005)

model of Parkinson's disease

CEC

(Roy and Jackson, 2014)

Hsap\MAPT^R406W.UAS

model of Alzheimer's disease

CEA

(Haddadi et al., 2016, Frost et al., 2014, Ryoo et al., 2007)

model of tauopathy

CEA

(Haghi et al., 2025, Amini et al., 2024, Nair et al., 2024, Ortiz-Vega et al., 2024, Pragati and Sarkar, 2024, Zuniga et al., 2024, Beckmann et al., 2023, Ochoa et al., 2023, Schulz et al., 2023, Zuniga et al., 2023, Farrell et al., 2022, Shafik et al., 2022, Sun et al., 2022, Zhang et al., 2022, Abreha et al., 2021, Li et al., 2021, Nikookar et al., 2021, Abtahi et al., 2020, Krishnaswamy et al., 2020, Lohr et al., 2020, Ma et al., 2020, Mahoney et al., 2020, Cornelison et al., 2019, He et al., 2019, Kadas et al., 2019, Park et al., 2019, Tuxworth et al., 2019, Bardai et al., 2018, Guo et al., 2018, Kim et al., 2018, Berson et al., 2017, Chanu and Sarkar, 2017, Chanu and Sarkar, 2017, Dräger et al., 2017, Tsuda et al., 2017, Zhou et al., 2017, Bernstein et al., 2016, Frost et al., 2016, Haddadi et al., 2016, Ott et al., 2015, Huang et al., 2014, Povellato et al., 2014, Ali et al., 2012, Duboff et al., 2012, Feuillette et al., 2010, Kosmidis et al., 2010, Bilen and Bonini, 2007, Dias-Santagata et al., 2007, Fulga et al., 2007, Khurana et al., 2006, Mershin et al., 2004, Nishimura et al., 2004, Scherzer et al., 2003, Wittmann et al., 2001)

CEC

(Butzlaff et al., 2015, Huang et al., 2015, Merlo et al., 2014, McGurk and Bonini, 2012, Falzone et al., 2010)

model of amnestic disorder

CEA

(Mershin et al., 2004)

model of neurodegenerative disease

CEA

(Berger et al., 2006, Bilen et al., 2006, Khurana et al., 2006, Nishimura et al., 2004)

CEC

(Voßfeldt et al., 2012, Williamson and Hiesinger, 2010, Wang et al., 2007)

model of frontotemporal dementia

CEA

(Nitta et al., 2023, Zhang et al., 2022, Guo et al., 2018, Ali et al., 2012)

Hsap\MAPT^{R406W.S202A.UAS}

DOES NOT model neurodegenerative disease

CEA

(Nishimura et al., 2004)

DOES NOT model tauopathy

CEA

(Nishimura et al., 2004)

Hsap\MAPT^{R406W.S2A.UAS.0N4R}

DOES NOT model neurodegenerative disease

CEA

(Nishimura et al., 2004)

DOES NOT model tauopathy

CEA

(Nishimura et al., 2004)

model of tauopathy

CEA

(Sun et al., 2022, Papanikolopoulou and Skoulakis, 2015)

CEA with Hsap\MAPT^{R406W.S2A.UAS.0N4R}

(Lee et al., 2012)

Hsap\MAPT^UAS.cAa

DOES NOT model tauopathy

CEA

(Papanikolopoulou et al., 2010)

model of tauopathy

CEA

(Chatterjee et al., 2023, Wong et al., 2021, Quraishe et al., 2016, Cowan et al., 2015, Mudher et al., 2004)

model of Alzheimer's disease

CEA

(Sinadinos et al., 2013)

Hsap\MAPT^UAS.cWa

model of tauopathy

CEA

(Pragati and Sarkar, 2025, Ortiz-Vega et al., 2024, Pragati and Sarkar, 2024, Sultanakhmetov et al., 2024, Nitta et al., 2023, Oba et al., 2023, Zhang et al., 2022, Abreha et al., 2021, Aqsa and Sarkar, 2021, Napoletano et al., 2021, Park et al., 2021, Pragati and Sarkar, 2021, Abtahi et al., 2020, Feuillette et al., 2020, Krishnaswamy et al., 2020, Oba et al., 2020, Berson et al., 2019, He et al., 2019, Higham et al., 2019, Kadas et al., 2019, Saito et al., 2019, Guo et al., 2018, Kim et al., 2018, Papanikolopoulou et al., 2018, Chanu and Sarkar, 2017, Chanu and Sarkar, 2017, Dourlen et al., 2017, Galasso et al., 2017, Malmanche et al., 2017, Oka et al., 2017, Bernstein et al., 2016, Chouhan et al., 2016, Haddadi et al., 2016, Wu et al., 2013, Xiong et al., 2013, Ali et al., 2012, Duboff et al., 2012, Iijima-Ando et al., 2012, Reinecke et al., 2011, Talmat-Amar et al., 2011, Colodner and Feany, 2010, Feuillette et al., 2010, Iijima et al., 2010, Kosmidis et al., 2010, Papanikolopoulou et al., 2010, Yeh et al., 2010, Yeh et al., 2010, Steinhilb et al., 2007, Mudher et al., 2004, Nishimura et al., 2004, Wittmann et al., 2001)

CEC

(Park et al., 2012, Falzone et al., 2010, Iijima-Ando et al., 2010)

model of Alzheimer's disease

CEA

(Higham et al., 2019, Ando et al., 2016, Haddadi et al., 2016, Frost et al., 2014)

CEC

(Menzies et al., 2015)

model of neurodegenerative disease

CEA

(Berger et al., 2006, Bilen et al., 2006, Nishimura et al., 2004)

CEC

(Williamson and Hiesinger, 2010)

model of Parkinson's disease

CEA

(Wu et al., 2013)

model of Alzheimer's disease 1

CEA

(Barros and Bossing, 2021)

Hsap\MAPT^V337M.UAS

model of Alzheimer's disease

CEA

(Haddadi et al., 2016, Shulman et al., 2011)

model of tauopathy

CEA

(Pragati and Sarkar, 2024, Nisha and Sarkar, 2022, Aqsa and Sarkar, 2021, Nisha and Sarkar, 2021, Pragati et al., 2020, Hsieh et al., 2019, Chanu and Sarkar, 2017, Mao et al., 2017, Bernstein et al., 2016, Haddadi et al., 2016, Shulman et al., 2014, Xiong et al., 2013, Kosmidis et al., 2010, Shulman and Feany, 2003, Wittmann et al., 2001)

model of neurodegenerative disease

CEA

(Khurana et al., 2006)

model of frontotemporal dementia

CEA

(Pragati et al., 2020, Chanu and Sarkar, 2017)

Hsap\MAPT^{S262A.UAS.0N4R.cIAa}

model of tauopathy

CEA

(Papanikolopoulou and Skoulakis, 2015)

Hsap\MAPT^{T111A.T153A.UAS}

model of tauopathy

CEA

(Papanikolopoulou and Skoulakis, 2015, Steinhilb et al., 2007)

Hsap\MAPT^{T175A.T181A.UAS}

model of tauopathy

CEA

(Papanikolopoulou and Skoulakis, 2015, Steinhilb et al., 2007)

Hsap\MAPT^{S199A.T217A.UAS}

model of tauopathy

CEA

(Papanikolopoulou and Skoulakis, 2015, Steinhilb et al., 2007)

Hsap\MAPT^{S202A.T205A.UAS}

model of tauopathy

CEA

(Papanikolopoulou and Skoulakis, 2015, Steinhilb et al., 2007)

Hsap\MAPT^T212A.UAS

model of tauopathy

CEA

(Papanikolopoulou and Skoulakis, 2015, Steinhilb et al., 2007)

Hsap\MAPT^{T231A.S235A.UAS}

model of tauopathy

CEA

(Steinhilb et al., 2007)

Hsap\MAPT^{S396A.S404A.UAS}

model of tauopathy

CEA

(Steinhilb et al., 2007)

Hsap\MAPT^S422A.UAS

model of tauopathy

CEA

(Steinhilb et al., 2007)

Hsap\MAPT^S214A.UAS

model of tauopathy

CEA

(Papanikolopoulou and Skoulakis, 2015, Steinhilb et al., 2007)

Hsap\MAPT^AP5.UAS

model of tauopathy

CEA

(Steinhilb et al., 2007)

Hsap\MAPT^{UAS.2N4R.Tag:FLAG}

model of tauopathy

CEA

(Kosmidis et al., 2010)

Hsap\MAPT^{S238A.T245A.UAS.2N4R.Tag:FLAG}

model of tauopathy

CEA

(Papanikolopoulou and Skoulakis, 2015)

Hsap\MAPT^1-421.UAS

model of tauopathy

CEA

(Khurana et al., 2010)

Hsap\MAPT^UAS.2N4R.cUa

model of tauopathy

CEA

(Gusareva et al., 2018)

Hsap\MAPT^UAS.1N4R

model of tauopathy

CEA

(Folwell et al., 2010)

model of Alzheimer's disease

CEA with Hsap\APP^{Aβ42.UAS.cUa}

(Folwell et al., 2010)

Hsap\MAPT^{R406W.UAS.1N4R}

model of tauopathy

CEA

(Folwell et al., 2010)

model of Alzheimer's disease

CEA with Hsap\APP^{Aβ42.UAS.cUa}

(Folwell et al., 2010)

Hsap\MAPT^E14.UAS

model of tauopathy

CEA

(Zhang et al., 2022, Abtahi et al., 2020, Fernius et al., 2017, Zhou et al., 2017, Frost et al., 2016, Duboff et al., 2012, Talmat-Amar et al., 2011, Feuillette et al., 2010, Kosmidis et al., 2010, Yeh et al., 2010, Dias-Santagata et al., 2007)

model of Alzheimer's disease

CEA

(Frost et al., 2014)

Hsap\MAPT^44-230.UAS

model of tauopathy

CEA

(Reinecke et al., 2011)

Hsap\MAPT^P301L.GMR

model of tauopathy

CEA

(Martinez et al., 2022, Karsten et al., 2006)

Hsap\MAPT^V337M.GMR

model of tauopathy

CEA

(Xie et al., 2021)

Hsap\MAPT^UAS.VTR

model of Alzheimer's disease

CEA with Hsap\APP^695.UAS.Exel, Hsap\BACE1^UAS.Exel

(Yeh et al., 2018)

Hsap\MAPT^UAS.B

model of tauopathy

CEA

(Singh et al., 2024, Minjarez et al., 2016, Kosmidis et al., 2010)

Hsap\MAPT^AP.UAS

model of tauopathy

CEA

(Talmat-Amar et al., 2011, Yeh et al., 2010)

Hsap\MAPT^UAS.2N4R

model of tauopathy

CEA

(Povellato et al., 2014)

Hsap\MAPT^UAS.0N4R

model of tauopathy

CEA

(Povellato et al., 2014)

Hsap\MAPT^{R406W.UAS.0N4R}

model of tauopathy

CEA

(McInnes et al., 2018)

Hsap\MAPT^{S202A.UAS.2N4R}

model of tauopathy

CEA

(Povellato et al., 2014)

Hsap\MAPT^{S205A.UAS.2N4R}

model of tauopathy

CEA

(Povellato et al., 2014)

Hsap\MAPT^{T212A.UAS.2N4R}

model of tauopathy

CEA

(Povellato et al., 2014)

Hsap\MAPT^{S404A.UAS.2N4R}

model of tauopathy

CEA

(Povellato et al., 2014)

Hsap\MAPT^4xA.UAS.2N4R

model of tauopathy

CEA

(Dourlen et al., 2017, Povellato et al., 2014)

model of Alzheimer's disease

CEA

(Chapuis et al., 2013)

Hsap\MAPT^UAS.2N4R.cAa

model of tauopathy

CEC

(Appocher et al., 2014)

CEC with ReepA^Δ258

(Appocher et al., 2014)

Hsap\MAPT^UAS.2N4R.cGa

model of tauopathy

CEA

(Geng et al., 2015)

Hsap\MAPT^{45-441.UAS.Tag:MYC}

model of tauopathy

CEA

(Geng et al., 2015)

Hsap\MAPT^{231-441.UAS.Tag:MYC}

model of tauopathy

CEA

(Geng et al., 2015)

Hsap\MAPT^UAS.2N4R.cSa

model of tauopathy

CEA

(Kim et al., 2023, Asadzadeh et al., 2022, Santa-Maria et al., 2015)

Hsap\MAPT^UAS.2N4R.wt

model of tauopathy

CEA

(Zhu et al., 2022, Gorsky et al., 2016)

Hsap\MAPT^{K280R.UAS.2N4R}

model of tauopathy

CEA

(Gorsky et al., 2016)

Hsap\MAPT^{K280Q.UAS.2N4R}

model of tauopathy

CEA

(Gorsky et al., 2016)

Hsap\MAPT^{UAS.0N4R.Tag:FLAG}

model of Alzheimer's disease

CEA

(Bougé and Parmentier, 2016)

Hsap\MAPT^{R406W.UAS.cUa}

model of tauopathy

CEA

(Shafik et al., 2021, Haghi et al., 2020, Gregory et al., 2017, Sun et al., 2016, Pfleger et al., 2010)

Hsap\MAPT^{UAS.2N4R.cSMa}

model of tauopathy

CEA

(Tsuda et al., 2017, Sheik Mohideen et al., 2015)

Hsap\MAPT^S2A.UAS.0N4R

model of tauopathy

CEA

(Oba et al., 2020, Ando et al., 2016)

Hsap\MAPT^UAS.2N4R.cFa

model of tauopathy

CEA

(Vourkou et al., 2022, Fernius et al., 2017)

Hsap\MAPT^UAS.2N3R.cFa

model of tauopathy

CEA

(Vourkou et al., 2022)

Hsap\MAPT^UAS.1N4R.cFa

model of tauopathy

CEA

(Vourkou et al., 2022)

Hsap\MAPT^UAS.1N3R.cFa

model of tauopathy

CEA

(Vourkou et al., 2022)

Hsap\MAPT^UAS.0N4R.cFa

model of tauopathy

CEA

(Catterson et al., 2024, Vourkou et al., 2022, Sandberg et al., 2020, Fernius et al., 2017)

model of progressive supranuclear palsy

CEA

(Sandberg et al., 2020)

Hsap\MAPT^UAS.0N3R.cFa

model of tauopathy

CEA

(Prifti et al., 2022, Vourkou et al., 2022, Sandberg et al., 2020)

model of progressive supranuclear palsy

CEA

(Sandberg et al., 2020)

model of Alzheimer's disease 1

CEA

(Barros and Bossing, 2021)

Hsap\MAPT^UAS.cUa

model of tauopathy

CEA

(Tao et al., 2024, Yadav et al., 2024, Kim et al., 2021, Lasagna-Reeves et al., 2016)

CEA with Hsap\RAPGEF3^{Epac1-camps.UAS}

(Dissel et al., 2017)

model of Alzheimer's disease

CEA

(Ataellahi et al., 2023)

Hsap\MAPT^UAS.cSa

model of tauopathy

CEA

(Sakakibara et al., 2023)

model of Alzheimer's disease

CEA

(Sakakibara et al., 2018, Sekiya et al., 2018)

Hsap\MAPT^{R406W.UAS.2N4R.Tag:FLAG}

model of tauopathy

CEA

(Papanikolopoulou et al., 2018)

Hsap\MAPT^R5L.UAS.cBa

model of frontotemporal dementia

CEA

(Bardai et al., 2018)

model of tauopathy

CEA

(Bardai et al., 2018)

Hsap\MAPT^{S320F.UAS.cBa}

model of frontotemporal dementia

CEA

(Bardai et al., 2018)

model of tauopathy

CEA

(Bardai et al., 2018)

Hsap\MAPT^{S352L.UAS.cBa}

model of frontotemporal dementia

CEA

(Bardai et al., 2018)

model of tauopathy

CEA

(Bardai et al., 2018)

Hsap\MAPT^{G389R.UAS.cBa}

model of frontotemporal dementia

CEA

(Bardai et al., 2018)

model of tauopathy

CEA

(Bardai et al., 2018)

Hsap\MAPT^{R406W.UAS.cBb}

model of tauopathy

CEC

(Twyning et al., 2024)

CEA

(Bardai et al., 2018)

model of frontotemporal dementia

CEA

(Bardai et al., 2018)

Hsap\MAPT^0N3R.UAS.cFb

model of tauopathy

CEA

(Kadas et al., 2019)

Hsap\MAPT^4R.UAS

model of Alzheimer's disease

CEA with lap^KK109279

(Moreau et al., 2014)

CEA with lap^GD4725

(Moreau et al., 2014)

CEA with lap¹

(Moreau et al., 2014)

Hsap\MAPT^UAS.0N4R.cUa

model of tauopathy

CEA

(Yu et al., 2024, Vourkou et al., 2023, Nangia et al., 2021, Keramidis et al., 2020, Buhl et al., 2019, Scarpelli et al., 2019, Sealey et al., 2017)

Hsap\MAPT^{V337M.UAS.cUa}

model of tauopathy

CEA

(Yadav et al., 2024)

Hsap\MAPT^UAS.0N4R.cPa

model of tauopathy

CEA

(Passarella and Goedert, 2018)

Hsap\MAPT^{tau.1N4R-V337M}

model of frontotemporal dementia

CEA

(Law et al., 2022, Cassar et al., 2020)

Hsap\MAPT^lexAop.2N4R

model of tauopathy

CEA

(Kilian et al., 2017)

Hsap\MAPT^E14FL.UAS

model of tauopathy

CEA

(Chi et al., 2020)

Hsap\MAPT^E14D421A.UAS

model of tauopathy

CEA

(Chi et al., 2020)

Hsap\MAPT^APFL.UAS

model of tauopathy

CEA

(Chi et al., 2020)

Hsap\MAPT^APD421A.UAS

model of tauopathy

CEA

(Chi et al., 2020)

Hsap\MAPT^AP421.UAS

model of tauopathy

CEA

(Chi et al., 2020)

Hsap\MAPT^{R406W.UAS.2N4R.cBa}

model of frontotemporal dementia

CEA

(Beharry et al., 2013)

Hsap\MAPT^PH.UAS.2N4R

model of frontotemporal dementia

CEA

(Beharry et al., 2013)

Hsap\MAPT^{PH.R406W.UAS.2N4R}

model of frontotemporal dementia

CEA

(Beharry et al., 2013)

Hsap\MAPT^{S238E.UAS.0N4R}

model of tauopathy

CEA

(Keramidis et al., 2020)

Hsap\MAPT^{T245A.UAS.0N4R}

model of tauopathy

CEA

(Keramidis et al., 2020)

Hsap\MAPT^{T245E.UAS.0N4R}

model of tauopathy

CEA

(Keramidis et al., 2020)

Hsap\MAPT^{S238A.UAS.0N4R}

model of tauopathy

CEA

(Keramidis et al., 2020)

Hsap\MAPT^{S262A.UAS.0N4R}

model of tauopathy

CEA

(Keramidis et al., 2020)

Hsap\MAPT^{S262E.UAS.0N4R}

model of tauopathy

CEA

(Keramidis et al., 2020)

Hsap\MAPT^STA.UAS.0N4R

model of tauopathy

CEA

(Keramidis et al., 2020)

Hsap\MAPT^UAS.Tag:FLAG

model of tauopathy

CEA

(Cragnaz et al., 2014)

Hsap\MAPT^{G273R.UAS.0N4R}

model of tauopathy

CEA

(Sandberg et al., 2020)

model of progressive supranuclear palsy

CEA

(Sandberg et al., 2020)

Hsap\MAPT^{G273R.UAS.0N3R}

model of tauopathy

CEA

(Sandberg et al., 2020)

model of progressive supranuclear palsy

CEA

(Sandberg et al., 2020)

Hsap\MAPT^{UAS.2N4R.cPa.Tag:FLAG}

model of tauopathy

CEA

(Prifti et al., 2022, Prifti et al., 2021)

Hsap\MAPT^{C291A.UAS.2N4R.Tag:FLAG}

model of tauopathy

CEA

(Prifti et al., 2022, Prifti et al., 2021)

Hsap\MAPT^{C322A.UAS.2N4R.Tag:FLAG}

model of tauopathy

CEA

(Prifti et al., 2022)

Hsap\MAPT^{V337M.UAS.0N4R}

model of tauopathy

CEA

(McInnes et al., 2018, Zhou et al., 2017)

Hsap\MAPT^{P301L.UAS.0N4R}

model of tauopathy

CEA

(McInnes et al., 2018, Zhou et al., 2017)

Hsap\MAPT^UAS.cLa

model of tauopathy

CEA

(Losev et al., 2021)

Hsap\MAPT^N167Q.UAS

model of tauopathy

CEA

(Losev et al., 2021)

Hsap\MAPT^N359Q.UAS

model of tauopathy

CEA

(Losev et al., 2021)

Hsap\MAPT^N410Q.UAS

model of tauopathy

CEA

(Losev et al., 2021)

Hsap\MAPT^UAS.2N4R.cSb

model of tauopathy

CEA

(Saito et al., 2021)

Hsap\MAPT^S7A.UAS.2N4R

model of tauopathy

CEA

(Saito et al., 2021)

Hsap\MAPT^S7E.UAS.2N4R

model of tauopathy

CEA

(Saito et al., 2021)

Hsap\MAPT^{C291A.UAS.2N4R}

model of tauopathy

CEA with Hsap\MAPT^{C322A.UAS.2N4R}

(Saito et al., 2021)

Hsap\MAPT^{C322A.UAS.2N4R}

model of tauopathy

CEA with Hsap\MAPT^{C291A.UAS.2N4R}

(Saito et al., 2021)

Hsap\MAPT^{tau.1N4R-K369I}

model of Pick's disease

CEA

(Law et al., 2022)

Hsap\MAPT^D421E.UAS

model of tauopathy

CEA

(Asadzadeh et al., 2022)

Hsap\MAPT^{P301L.10xUAS.2N4R}

model of tauopathy

CEA

(Catterson et al., 2024)

Hsap\MAPT^{P301L.10xUAS.2N4R.CBG-NLuc}

model of tauopathy

CEA with Hsap\MAPT^{P301L.10xUAS.2N4R.CBG-CLuc}

(Levy et al., 2022)

Hsap\MAPT^{P301L.10xUAS.2N4R.CBG-CLuc}

model of tauopathy

CEA with Hsap\MAPT^{P301L.10xUAS.2N4R.CBG-NLuc}

(Levy et al., 2022)

Hsap\MAPT^UAS.0N4R.cVa

model of tauopathy

CEA

(Vourkou et al., 2023)

Hsap\MAPT^UAS.cRa

model of tauopathy

CEA

(Rousseaux et al., 2016)

Hsap\MAPT^{P301L.QUAS.0N4R}

model of tauopathy

CEA

(Praschberger et al., 2023)

Hsap\MAPT^tau.2N4R-WT

model of tauopathy

CEA

(Catterson et al., 2024)

Hsap\MAPT^{E14.20xUAS.0N4R.Tag:HA}

model of tauopathy

CEA

(Catterson et al., 2024)

Hsap\MAPT^UAS.0N3R.cUa

model of tauopathy

CEA

(Stubbs et al., 2023, Sealey et al., 2017)

Hsap\MAPT^{QUAS.2N4R.Tag:FLAG.T2A-GFP}

model of tauopathy

CEA

(Bankapalli et al., 2024)

Modifiers Based on Experimental Evidence ( 45 )

Allele

Disease

Interaction

References

Hsap\MAPT^UAS.GFP

model of tauopathy

is exacerbated by mask^HMS01045

(Zhu et al., 2017)

is ameliorated by mask^UAS.cZa

(Zhu et al., 2017)

Hsap\MAPT^UAS.wt

model of tauopathy

is exacerbated by sgg^UAS.cSa

(Chatterjee et al., 2009)

is exacerbated by par-1^UAS.cSa

(Chatterjee et al., 2009)

is ameliorated by AMPKα^UAS.cMa

(Li et al., 2024)

is exacerbated by mnb^UAS.Tag:FLAG

(Lee et al., 2020)

is ameliorated by Gcn5^RNAi.UAS

(Wang et al., 2020)

is exacerbated by Mitf^{2KQ.UAS.Tag:FLAG}

(Wang et al., 2020)

is exacerbated by Mitf^HMS00151

(Wang et al., 2020)

is ameliorated by Mitf^UAS.Tag:FLAG

(Wang et al., 2020)

is ameliorated by Hsap\APP^{Aβ42.UAS.cUa}

(Panchal and Tiwari, 2020)

is exacerbated by Hsap\APP^{Aβ42.UAS.cUa}

(Panchal and Tiwari, 2020)

is exacerbated by Miro^GL01583

(Panchal and Tiwari, 2020)

is ameliorated by Miro^UAS.cGa

(Panchal and Tiwari, 2020)

is exacerbated by mir-9a^{UAS.cSa.DsRed2}

(Subramanian et al., 2021)

is ameliorated by Hsap\UBE4B^UAS.cSa

(Subramanian et al., 2021)

is ameliorated by Ube4A^UAS.cSa

(Subramanian et al., 2021)

is ameliorated by mir-9a^{sponge.UAS.mCherry}

(Subramanian et al., 2021)

is exacerbated by mir-9b^{UAS.cluster.cSa.DsRed2}

(Subramanian et al., 2021)

is exacerbated by Ube4A^KK101530

(Subramanian et al., 2021)

is exacerbated by mir-9c^UAS.cSa

(Subramanian et al., 2021)

is exacerbated by β4GalT7^GD12632

(Frenkel-Pinter et al., 2017)

is exacerbated by Ost1^KK105430

(Frenkel-Pinter et al., 2017)

is exacerbated by OstΔ^HMS01092

(Frenkel-Pinter et al., 2017)

is exacerbated by Pgant5^GD903

(Frenkel-Pinter et al., 2017)

is ameliorated by β4GalT7^GD12632

(Frenkel-Pinter et al., 2017)

is ameliorated by OstΔ^HMS01092

(Frenkel-Pinter et al., 2017)

is exacerbated by NUCB1^KK107501

(Yang et al., 2024)

is ameliorated by NUCB1^{Nesfatin1.UAS}

(Yang et al., 2024)

ameliorates Parkinson's disease

modeled by Hsap\SNCA^UAS.cTa

(Roy and Jackson, 2014)

model of Parkinson's disease

is ameliorated by Hsap\SNCA^UAS.cTa

(Roy and Jackson, 2014)

Hsap\MAPT^GMR.S11A

model of tauopathy

is exacerbated by par-1^UAS.cSa

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ

model of tauopathy

is ameliorated by Rab5^S43N.UAS

(Bakhoum et al., 2014)

is ameliorated by Atg1^Δ3D

(Bakhoum et al., 2014)

is ameliorated by Atg2^UAS.cUa

(Bakhoum et al., 2014)

is ameliorated by Rab7^{T22N.UASp.YFP}

(Bakhoum et al., 2014)

is ameliorated by S6k^UAS.cUa

(Bakhoum et al., 2014)

is ameliorated by cathD^UAS.cUa

(Bakhoum et al., 2014)

is ameliorated by Diap2^GMR.PH

(Jackson et al., 2002)

is ameliorated by arm¹

(Jackson et al., 2002)

is ameliorated by sgg¹

(Jackson et al., 2002)

is ameliorated by Diap1^GMR.PH

(Jackson et al., 2002)

is ameliorated by BacA\p35^GMR.PH

(Jackson et al., 2002)

is ameliorated by arm⁴

(Jackson et al., 2002)

is exacerbated by arm^{S10.UAS.Tag:MYC}

(Jackson et al., 2002)

is exacerbated by pan^UAS.cWa

(Jackson et al., 2002)

is exacerbated by sgg^UAS.cSa

(Chatterjee et al., 2009, Jackson et al., 2002)

is ameliorated by Psa^GMR.Ex.PK

(Karsten et al., 2006)

is ameliorated by eIF1A^c04533

(Karsten et al., 2006)

is ameliorated by Vap33^Δ448

(Karsten et al., 2006)

is exacerbated by Psa⁰⁶²²⁶

(Karsten et al., 2006)

is exacerbated by stg^C379S.UAS

(Oliveira et al., 2023)

is exacerbated by stg^JF03235

(Oliveira et al., 2023)

is ameliorated by stg^UAS.cNa

(Oliveira et al., 2023)

is exacerbated by spin^Δ2b

(Dermaut et al., 2005)

is exacerbated by CycE^k05007